Box supports hardware and software 2FA through single sign-on integratio...

Box supports hardware and software 2FA through single sign-on integrations such as Ping Identity.

https://support.box.com/hc/en-us/articles/200526668-Does-Box-support-Single-Sign-On-SSO-
https://www.pingidentity.com/en/products/capabilities/multi-factor-authentication.html