Recommend removing the descriptions from these three items, e.g.:

    NucleotideSequence
    DNASequence
    RNASequence

numpydoc recommends leaving out the description if the functionality is apparent from the name alone.

Also, note that you can list these as comma-separated instead:

    NucleotideSequence, DNASequence, RNASequence

Not sure which way is preferred and I don't have strong feelings either way, just wanted to make a note.