I actually want 'shell more often than I want 'named-shell, so put 'shell on C-x S-1 and 'named-shell on C-x S-3.
Naming the shell spawned by C-x S-1 after the cwd is way more pleasant.
<f7> is a nice key for sticking pdb into a python file. :)
column-marker is occasionally useful.
Make tramp use a local backup directory.
tab-width 8 is slightly more useful for things like shell mode and Varnish. :)
Explicitly put the tab width changing for specific languages on specific mode hooks.