One-bond proton-carbon coupling constants (1JCH) depend on chemical structure, and can be easily measured by NMR.  They are a useful source of structural information because their dependence on structure is different from that of the carbon and proton chemical shifts and the effects of solvent are predictable.  They are especially useful for identifying strained rings (for example, the cyclopropyl groups present in Sedaxane and the norbornane present in Solatenol) and halogenated carbons (such as those present in Solatenol intermediates).  Unfortunately, no software programs exist to predict 1JCH so their interpretation requires experience and reading large tables from papers and books.  We propose funding a 6-month studentship at the European Bioinformatics Institute to develop the open-source Bioclipse software program for 1JCH prediction.  The accuracy of the program will be compared with quantum-mechanical 1JCH prediction using DFT methods.