PERF: performance improvements on isnull/notnull for large pandas objects

1000 x 1000 frame
```
-------------------------------------------------------------------------------
Test name                                    | head[ms] | base[ms] |  ratio   |
-------------------------------------------------------------------------------
frame_isnull                                 |   3.1417 | 121.2864 |   0.0259 |
```

now evaluates block-by-block rather than column-by-column