ADDAPTS, a Data-Driven Automated Pipeline and Tracking System. Much effort goes into handling the large amount of data produced by current sequencing technologies. The ADDAPTS relational database stores metadata about the samples and their associated data files. A controller process monitors the database and starts new pipeline jobs when appropriate. The dependencies between pipeline tasks are configured in the database itself, and can be modified without pausing the pipeline. The tracking system provides a web front-end for entering, viewing and editing metadata. It also generates charts and statistics for each sample, provides links to the files generated from the pipeline analysis, and generates global reports for all samples.