# Talk:Phosphatase

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Lovinne. Peer reviewers: Herrerais.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 06:35, 17 January 2022 (UTC)

Just keeping this safe in case it is needed.


### Metallophosphatases
The metalloenzymes by far comprise the greatest bulk of phosphatases, and contain such enzymes as alkaline phosphatase (three metal ions, only two of which are catalytically active), the serine threonine phosphatases and inositol monophosphatase (a key enzyme in manic depression).
The enzyme is found in lysosomes, and is used to dispose of unwanted RNA as well as generally maintain order within the cell. Other enzymes found in lysosomes include proteases.
Bassophile 15:24, 3 January 2007 (UTC)

I have incorporated Protein_Phosphatase into this one.
Bassophile 16:23, 3 January 2007 (UTC)

Note: proteins and lipids are not the only substrates of phosphotases - many phosphorylated compounds exist as potential targets, including nucleoside triphosphates as well as sugars to name two.  Someone should expand this article to account for this.

In the mechanism explanation -> 'CDP' in the case stands for cysteine-dependent phosphatase, not cytidine diphosphate.  — Preceding unsigned comment added by 74.131.99.84 (talk) 22:49, 5 November 2011 (UTC) 

This article, though named "Phosphatase", is largely about protein phosphatases, just one kind of phosphatase.  It seems to me that it should have a different name, or should be reworked. AlphaHelical (talk) 12:49, 9 May 2013 (UTC)

The most part has been split again to Protein phosphatase. Please enrich the content for phosphatase in general.--Mzaki (talk) 20:08, 21 May 2015 (UTC)

Hello, I intend to improve this article over the next couple months. I have assembled a preliminary bibliography consisting of the following sources:

-Fundamentals of Biochemistry; Voet, Voet, and Pratt (ISBN: 978-1-118-91840-1) 
-Direct determination of phosphatase activity from physiological substrates in cells (DOI: 10.1371/journal.pone.0120087).
-Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (DOI: 10.1126/scisignal.2004712)
-Human HAD phosphatases: structure, mechanism, and roles in health and disease (DOI: 10.1111/j.1742-4658.2012.08633.x) 
-How do inhibitory phosphatases work? (PMID: 12431385)

Thoughts on the sources? As for my intentions, I want to write a better general description for phosphatase, talk about its function and mechanisms, list/explain various classes of phosphatase, describe its role in cell signalling, and explore how it's regulated.
Lovinne (talk) 03:08, 7 February 2017 (UTC)
Hello, I've assembled an outline of my intended changes for this article:
Intentions for Edit of Phosphatase Article
I want to improve and expound upon the following aspects of the enzyme phosphatase:

Write a more detailed general description of the enzyme that addresses its general function, what class of enzymes it belongs to, and a brief overview of its roles in the body.
Explore the general catalytic mechanism of phosphatase.
Address significant aspects of physiological relevance
Write in greater detail about 3 major types of phosphatase, including definition, mechanism, and physiological relevance. Briefly discuss sub-classes.
Protein phosphatase
Mechanism
Subtypes: Ser/Thr, His, metallo-dependent
Role in signal transduction cascades, protein regulation,
Alkaline phosphatase
Mechanism
Roles in digestion, agriculture, cancer
Alkaline phosphatase
Mechanism
Roles in intestinal homeostatis, liver/bone/kidney, and developmental biology
Briefly overview significant uses of phosphatase inhibitors in drugs  — Preceding unsigned comment added by Lovinne (talk • contribs) 01:33, 14 February 2017 (UTC)