# Talk:Down syndrome

it reads "life long". it should read "lifelong".

I'm literally replying here just to add my sig which will allow archiving to happen, now it's been fixed.  For the record, the term "life long" no longer appears in the article anyway.  Chaheel Riens (talk) 12:40, 6 June 2025 (UTC)

On children, down syndrome is less obvious in the face. Český uživatel 99 (talk) 21:48, 14 August 2025 (UTC)

"If the screening test has a 2% false-positive rate, this means of 11 women who test positive on screening, only one will have a fetus with Down syndrome" This line cites a paywalled article, so I can't verify it's contents. I don't believe this is how the math works out from my 30 seconds of research and I suspect this would be original research, I doubt people reading the cited article would need someone to make up an analogy about 11 women. Would someone verify the math and/or the source? I can do stuff!  (talk) 22:06, 20 August 2025 (UTC)

I verified the content to the source. The source is available via the wikipedia library.
To put this in a quantitative context, if we consider the background risk of Down syndrome pregnancy to be 1 in 500, applying a screening test with a 90% detection rate and a 5% false positive rate to this population means that 1 in every 28 women called screen positive will actually have an affected pregnancy, while 27 of the 28 will have been falsely called positive. If the screening test has a 90% detection rate and only a 2% false positive rate, one in every 11 women called screen positive will actually have an affected pregnancy, while 10 of the 11 will have been falsely called positive.
I wonder if this kind of quantitative but confusing analysis is suitable for wikipedia. I think the points in the same article about the negative effects of 5% false positive may be more valuable. Johnjbarton (talk) 01:32, 21 August 2025 (UTC)

It is by definition a disease as it has a clear underlying cause and stating that a disease has to have an external cause is not factually correct. By pure scientific definition it is a disease due to it being a set of symptoms caused by a known caused and mechanism of action. That known cause being a genetic mutation. You can't pick and choose definitions to make people happy if that ruins the science 2001:8003:30C9:F200:DB00:978C:EBB1:96E6 (talk) 23:26, 3 November 2025 (UTC)

 Not done: It's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. - Umby 🌕🐶 (talk) 23:39, 3 November 2025 (UTC)