# Talk:Methamphetamine

Hello. Requesting that the following category be added to this semi-protected page:

[[Category:Monoaminergic activity enhancers]]

See the monoaminergic activity enhancer page for details and sources. Thank you. 98.191.202.231 (talk) 19:57, 25 July 2024 (UTC)

 Done Professional Crastination (talk) 04:40, 28 July 2024 (UTC)
Hmmm... it seems that the category is still missing actually. Would you mind checking it again, Professional Crastination? Thank you. 174.66.87.253 (talk) 19:27, 17 August 2024 (UTC)
@174.66.87.253, I owe you an apology. I distinctly remmeber adding that line to the source code, but, I've just checked the revision history for this article and there's no update from me on the 28th. So, I assume I simply forgot to click publish afterwards because of sleep deprivation and/or my medication having worn off. My bad.
Anyway, I've rectified this in the latest revision of the page. Professional Crastination (talk) 10:21, 19 August 2024 (UTC)

@Whywhenwhohow Why were citations from DrugBank annotated as an unreliable medical source? Professional Crastination (talk) 05:58, 27 October 2024 (UTC)

Drugbank doesn't meet the requirements of WP:MEDRS. It is not a peer-reviewed reliable source. --Whywhenwhohow (talk) 06:01, 27 October 2024 (UTC)
DrugBank is a tertiary source that provides aggregated biochemical data. It's an authoritative repository maintained by the University of Alberta and is underpinned by peer-reviewed primary and secondary sources, all of which are cited on the DrugBank entry for methamphetamine. DrugBank's recognised reliability is why it's included in the infobox of all drug-related articles on Wikipedia, per WP:MEDMOS.
Virtually all of the unreliable tags you added were appended to statements concerning molecular neuropharmacology, not medical claims a la clinical implications. Medical reviews are also reasonable sources to use for this, but I'm assuming that whoever wrote/cited those statements referenced DrugBank because (IME) medical reviews are typically not as comprehensive as DrugBank and similar databases (e.g., bindingDB, IUPHAR, etc.) for a the enzymes involved in a particular drug's metabolic pathways, its receptor binding data, and other pharmacological attributes. That said, I do agree with you about DrugBank's reliability for supporting the following sentence "Methamphetamine is metabolized by the liver enzyme CYP2D6, so CYP2D6 inhibitors will prolong the elimination half-life of methamphetamine"; the italicised portion of that sentence introduces a clinical implication, which should reference from a secondary source (e.g., the USFDA Rx label for Desoxyn supports that claim, if I recall correctly). I'm happy to go ahead and address that by appending an appropriate secondary source to the end of that sentence, if you're happy for that to be the outcome of this discussion. Professional Crastination (talk) 08:09, 27 October 2024 (UTC)
I just re-read WP:MEDRS. DrugBank sure seems to tick off all the boxes as being an excellent WP:MEDRS. It has a lot going for it. Among the things going for it, DrugBank gets much more peer review than a typical scientific review article, as it is receiving constant community feedback. Also, The NCATS Biomedical Translator uses Drugbank as one of its datasources. DrugBank is not perfect, but perfection is not a WP:MEDRS requirement. Jaredroach (talk) 21:12, 27 October 2024 (UTC)
In my experience, DrugBank frequently contains errors and it does not claim to be peer reviewed. --Whywhenwhohow (talk) 04:29, 10 December 2024 (UTC)

Requesting input on this topic here at WikiProject Pharmacology. Thanks. – AlyInWikiWonderland (talk, contribs) 16:00, 13 December 2024 (UTC)

103.82.0.25 (talk)911 WAS AN INSIDE JOB

 Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Sophisticatedevening (talk) 14:57, 26 February 2025 (UTC)

In the last paragraph of the Medical section of the Uses section, please change "...a extended-release..." to "...an extended-release..." ClockByeBye (talk) 20:36, 7 March 2025 (UTC)
 Done PianoDan (talk) 23:30, 7 March 2025 (UTC)

I swear to god people have told me it lasts about 6 hours and they used ammonia, not methylamine in the manufacturing of "meth". Amphetamine has been known to make people very violent, well, a specific population, people in Cluster B and C personality disorders. Actual methamphetamine has displayed increased cognition but heightened paranoia and shadow people despite being awake for only 18 hours. Methamphetamine activates sigma1-receptors which contributes to the stronger creativity aspect of it but that ends up blending into reality like 8 - 16 hours later. It has lasted 7 days after one dose in some people due to non-linear pharmacokinetics. 

Meth should be "Methamphetamine Hydrochloride" not "Amphetamine Hydrobromide"

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)PO_)_(*((&**&^TG&^G& Dmhpman101 (talk) 23:42, 7 July 2025 (UTC)

Neater chemical structure and drug nerd who has done real meth Fenetermine (talk) 05:08, 16 July 2025 (UTC)

 Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. UmbyUmbreon (talk) 05:18, 16 July 2025 (UTC)

Greetings and good day! I wanted to clarify an error made on this page that I feel is important due to it's medical inaccuracy. With regard to the statement in the first section 1st paragraph, perhaps the second, it states that on note 3 that Desoxyn medical information insert, that the active ingredient is dextroamphetamine, and also claims there to be some elaborate different chemical that claims to be proof it is dextroamphetamine. That...is 100%  absolutely not true. Adderall is dextroamphetamine. Desoxyn is the prescription name brand of the drug Methamphetamine hcl. It comes in 5mg and 10mg tablets. 5mg and 10mg of dextroamphetamine are barely therapeutic doses for a 6 year old child, much less for anyone older than that. Desoxyn is prescribed for a variety of disorders, illnesses, or activities. This includes for ADHD, hypothyroidism that 1 results in uncontrollable weight gain, and 2 for lethargy for that and similar conditions, narcolepsy, obesity and weight loss, for patients suffering from low stamina for any number of reasons, major depressive disorder, and apparently minor and major traumatic brain injuries and others. Activities may prescribe Desoxyn including: Over night flights in fighter jets and bomber aircraft, long missions carried out by military soldiers, and other civilian activities that require focus, and alertness with a small margin for falling asleep or suffering from something similar to sentry fatigue.

I definitely am absolutely sure this to be true, and who or whomever edited this is playing with fire, it is never okay to lie or deceive others simply because you may disagree or dislike a drug or it's effects. Wikipedia is supposed to be based in fact, not someone's personal attempt to mislead people.

Please, change the article so that it is accurate before someone reads this for the sake of researching the drug and is provided with false information. This kind of thing has killed people, giving readers a false sense of security and potentially leading to overdose as like I stated 5mg of dextroamphetamine is not even a therapeutic dose, while 5mg of Methamphetamine to a person that has not taken it before is much different and much much stronger than dextroamphetamine. I definitely do not want that to ever happen so please change this.
Thank you so much, have a great day! 2600:100F:B203:B54D:B432:6933:786:89A (talk) 01:05, 18 October 2025 (UTC)

 Not done: please provide reliable sources that support the change you want to be made. Bowler the Carmine | talk 05:22, 18 October 2025 (UTC)
 Not done: I have reviewed the article, and your claims do not align with the current contents of the article. I believe that you are getting dextromethamphetamine confused with dextroamphetamine. The two are distinctly different chemical compounds. Desoxyn is declared as methamphetamine, but actually contains dextromethamphetamine. No other FDA approved drug contains dextromethamphetamine. The various amphetamine isomers used in other FDA approved amphetamine-based drugs are dextroamphetamine (Dexedrine, Zenzedi), the dextroamphetamine prodrug lisdexamfetamine (Vyvanse), mixtures of various different dextroamphetamine and levoamphetamine salts (Adderall, Adderall XR, Mydayis), or racemic amphetamine (Evekeo). Hope this helps clarify things for you. Garzfoth (talk) 22:14, 19 October 2025 (UTC)

In the overdose section, the word "hyperpyrexia" is formatted as "hyperpy rexia". I think the space should be removed" Zamasm99 (talk) 20:34, 29 October 2025 (UTC)

 Done - thanks for pointing that out - Arjayay (talk) 20:42, 29 October 2025 (UTC)