Vetsupply: Simparica Trio is a powerful oral treatment that provides triple protection. It protects your dog against fleas and paralysis ticks, intestinal worms and deadly heartworm. Simparica Trio treats and protects against harmful parasites. The oral chew contains a specially optimised trio of ingredients for proven efficacy including the ingredient moxidectin, the same ingredient used by vets to protect against deadly heartworm disease. Simparica Trio kills fleas and paralysis ticks as well as provides persistent protection against flea and tick for five weeks.