Combination with epoprostenol The combination of bosentan and epoprostenol has been investigated in two studies: AC-052-355 (BREATHE-2) and AC-052-356 (BREATHE-3).
in vitro data showed that bosentan had no relevant inhibitory effects on CYP isoenzymes (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C9, 2D6, 2E1, 3A4).