CREATE TABLE "table1_225093_4" (
  "district" text,
  "vacator" text,
  "reason_for_change" text,
  "successor" text,
  "date_successor_seated" text
);

Question: How many vacators have October 22, 1808 as date successor seated?
SQL: SELECT COUNT("vacator") FROM "table1_225093_4" WHERE "date_successor_seated"='October 22, 1808';

Question: What is the date successor seated where Massachusetts 2nd is the district?
SQL: SELECT "date_successor_seated" FROM "table1_225093_4" WHERE "district"='Massachusetts 2nd';

Question: Who is the successor when the reason for change is seat declared vacant January 2, 1808
SQL: SELECT "successor" FROM "table1_225093_4" WHERE "reason_for_change"='Seat declared vacant January 2, 1808';

Question: Which district has John Culpepper (f) as the vacator?
SQL: SELECT "district" FROM "table1_225093_4" WHERE "vacator"='John Culpepper (F)';