Patent ID: 11794007

Abstract:
A bone stimulating method and device for treating injured or diseased bone tissue, includes exposing the injured or diseased bone tissue to a first electric field over a predetermined treatment period, the first electric field ranging from 10 mV/cm to 40 mV/cm and having a first predetermined time period within the predetermined treatment period and exposing the injured or diseased bone tissue to a second electric field over the predetermined treatment period, the second electric field ranging from 10 mV/cm to 60 mV/cm and having a second predetermined time period within the predetermined treatment period that is greater than the first predetermined time period. The first electric field is specific and selective for up-regulating expression of specific bone cell genes in the injured or diseased bone tissue when the injured or diseased bone tissue containing the specific bone cell genes is exposed to the first electric field and the second electric field is specific and selective for up-regulating expression of specific bone stem cell genes in the injured or diseased bone tissue when the injured or diseased bone tissue containing the specific bone stem cell genes is exposed to the second electric field.