Patent ID: 10894828

Abstract:
The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≤7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≤1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.