Patent ID: 10961213

Abstract:
The present invention relates to a process for preparing benzylic amides of formula I wherein the variables have the meaning as defined in the description, by reductive amidation of a nitrile of formula II  wherein the variables have the meanings given for formula I, with an activated carbonyl compound of formula III,  and which nitrile is obtained by reaction of a compound of formula IV  with a halogen compound of formula V,  wherein X is a halogen atom, preferably bromo, which halogen compound V in turn is obtained by Sandmeyer reaction of an aniline derivative of formula VI  novel compounds of formula I, and processes for preparing compounds of formula XII  wherein the variables have the meaning as defined in the description by condensing compounds of formula I with compounds of formula X  and subjecting the resulting α,β-unsaturated ketone of formula XI  to a reaction with hydroxylamine to yield compounds of formula XII.