Patent ID: 10981913

Abstract:
An object of the invention is to provide a 11C-labeled O6-benzylguanine capable of obtaining a PET image and a process for producing the same.The 11C-labeled O6-benzylguanine of the invention is represented by the following chemical formula (a). The 11C-labeled O6-benzylguanine is produced by: a coupling step of cross-coupling a methyl iodide labeled with 11C and the following organotin compound (b) (R1 represents an alkyl group, and R2 and R3 represent a leaving group which can be eliminated with a base) in the presence of a palladium complex, a phosphine ligand, and cuprous halide in an aprotic lactam; and a desorption step of desorbing the leaving groups R2 and R3 of the coupling product obtained by the coupling step with a base.