Patent ID: 11198728

Abstract:
Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising:a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231,wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308,and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; andb) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462,wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539,and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616The monoclonal antibody is characterized in that it inhibits IL-1RAcP induced NFkB activity, useful in treatment of IL-1RAcP related diseases.