Patent ID: 11912444

Abstract:
A method for conditioning a hard gelatin capsule (50) having any moisture content to a dry and non-brittle state when packed for at least one week in a cavity (45) of a blister base (40) closed by a lid film (35) comprising an aluminium foil, wherein the hard gelatin capsule (50) is a hard starch capsule manufactured from collagen and the hard gelatin capsule (50) contains pharmaceuticals and wherein the dry state of the hard gelatin capsule (50) means a relative humidity of less than 50% at room temperature and the non-brittle state means that the hard gelatin capsule (50) does not break when pressed out of the cavity (45) of the blister base (40) through the lid film (35). The lid film (35) and/or the blister base (40) comprise/s a moisture-regulating buffer layer (20) with a predefined humidity. The moisture-regulating buffer layer (20) consists of a polymer or polymer mixture containing 1 to 60 wt. % of an absorber material which is either a hygroscopic salt, a silica gel or a zeolite or a mixture of any of said absorber materials, wherein the absorber material buffers the humidity in the space within the cavity (45) surrounding the hard gelatin capsule (50) to lie in a range between 10 and 50% r.h.