Patent ID: 11066421

Abstract:
Novel cinchona alkaloid compounds have been synthesized and discovered to have potent cytotoxic activity against cancer cells both in vitro and in vivo.Cinchona alkaloids, including trimeric cinchona alkaloids as well as their polymers can be used as catalysts of complex chemical reactions in organic chemistry, for example for the enantioselective desymmetrization of cyclic anhydrides, asymmetric synthesis of amino acids (Ayyanar Siva, Eagambaram Murugan. Synthesis 2005; 17:2927-2933; Hyeung-geun Park et al. Tetrahedron Letters, Volume 42, Issue 28, 2001, Pages 4645-4648; Shohei Takata et al., RSC Adv., 2016, 6, 72300-72305; Masud Parvez et al., Macromolecules 2014, 47, 6, 1922-1928; Marcelli, T. 2007, UvA-DARE (Digital Academic Repository). https://pure.uva.nl/ws/files/4416997/52576_marcelli_thesis.pdfCompounds described herein exhibit broad-spectrum therapeutic efficacy against different cancer types, including leukemias/lymphomas, prostate cancer, breast cancer, malignant melanoma, aggressive brain tumor/glioblastoma multiforme (GBM), non-small cell lung cancer. The chemical structure of the compounds includes a trimeric cinchona alkaloid and derivatives containing various groups attached in their structure.