Patent ID: 11053608

Abstract:
Field of application: This invention relates to the chemistry of nucleotides and allows to synthesize new combinatorial libraries of supramolecular oligonucleotides for use in medical fields, cosmetology and pharmaceutical industry. This invention also can be applied for the creation of means used in the body rejuvenation, treating human diseases such as cancer, trophic ulcers, creating new herbicides and pesticides.The essence of the invention Combinatorial derivatives of RNA oligonucleotides, wherein for their production, covalent modification of the initial RNA oligonucleotides is carried out by simultaneous combinatorial carboxylation and formylation of the exocyclic amino groups of adenine, guanine, cytosine and the ribose alcohol residue in the reaction with the maximum number of different synthesis derivatives, and as a result of synthesis, a combinatorial mixture of derivatives of each oligonucleotide is formed and then use the resulting combinatorial mixture as a whole without fragmentation to create biologically active compositions.