Patent ID: 11399773

Abstract:
Time-efficient identification of a brain network input-output (IO) dynamics model for brain stimulation includes generating an input stochastic-switched noise-modulated waveform characterized by at least one parameter modulated according to a stochastic-switched noise sequence, inputting the input stochastic-switched noise-modulated waveform to a clinical brain-response system, recording one or more time-correlated outputs of the clinical brain-response system responsive to the input stochastic-switched noise-modulated waveform, and identifying a brain network IO dynamics model that optimally correlates the input stochastic-switched noise-modulated waveform to the one or more time-delimited outputs of the clinical brain-response system. A desired brain response to an input electrical signal may be obtained using the model, such as by modulating the input electrical signal using a closed-loop control algorithm based on the brain network IO dynamics model.