Patent ID: 11827667

Abstract:
[Problem] To develop a technique that can stabilize the higher-order structure of a nucleic acid and can be used in analysis of nucleic acid structure. [Solution] This guanosine derivative compound is represented by formula 1. In the formula, one of R1 and R2 represents H, and the other represents any of H, OH, OCH3, and F, R3 represents a functional group that is for detection and that has 19F, R4 represents an amine-protecting group, R5 represents a hydroxy group-protecting group, and R6 represents an introduction group that is to be introduced into a nucleic acid oligomer. This guanosine derivative compound can be introduced as a part of a nucleic acid sequence, and the introduced nucleic acid oligomer stabilizes the higher-order structure in a nucleic acid, and enables dynamic detection by 19F NMR.