Patent ID: 11162082

Abstract:
Provided is a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate, the microorganism further having a gene coding for a mutant phosphoserine aminotransferase having an improved L-homoserine aminotransferase activity converting by transamination L-homoserine into 4-hydroxy-2-ketobutyrate. Also provided is a method for the production of derivatives of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate by culturing the genetically modified microorganism in a culture medium and recovering the desired derivative.