Patent ID: 11192921

Abstract:
A polypeptide with analgesic activity and use thereof is disclosed. The polypeptide has the amino acid sequence of Xa-Xb-Cys-Ser-Thr-Pro-Pro-Xc-Xd-Val-Leu-Tyr-Xe (SEQ ID NO: 1), or a pharmaceutically acceptable salt thereof, wherein the Xa is Gly or deleted, the Xb is one of Ser or Lys; the Xc is one of d-Cys or Ser or Asp, the Xd is Ala or deleted; and the Xe is Cys or Ser. One pair of disulfide bonds are formed between two cysteines in the sequence. The polypeptide has good inhibitory effects on physicochemical irritating pain and pathological and neuropathic pain, and has good analgesic effects in various experimental models. The specific effects of the polypeptide are to significantly increase the threshold of pain of mice, prolong the heat tolerance time of mice, and the adverse reactions such as spontaneous movement and excitability of mice are lower than normal values.