Patent ID: 11717489

Abstract:
Chitosan can be coated, e.g., in 0.06 or 0.6 wt. %, over spherical silica, e.g., HYPS, loaded with spinel ferrites of theoretical formula MFe2O4, wherein M is Ni, Cu, Co, and/or Mn, e.g., at 30 wt. %, and cisplatin. Chitosan can be fabricated over Pt or cisplatin) bound CuFe2O4-HYPS and CuFe2O4-HYPS followed by Pt loading. Cisplatin and Pt—CuFe2O4-HYPS-chitosan at 0.025 to 0.5 mg/mL exhibit cytotoxicity against human breast cancer cell line (MCF-7) and human embryonic kidney cells (HEK293), relative to Pt—CuFe2O4-HYPS, with Pt—CuFe2O4-HYPS-chitosan, showing non-significant anti-cancer effects due to mediated Pt release. Pt—CuFe2O4/HYPS and CuFe2O4-HYPS-chitosan-Pt reduced cell viability using a different dose effect. Cisplatin in certain composites was less cytotoxic to HEK293 than MCF7, making the a targeted drug delivery system. Inventive composites may improve multifunctional theranostic applications involving pH stimuli, temperature-based drug release, and diagnosis based treatment such as hyperthermia.