Patent ID: 11975071

Abstract:
A method for ablating cancerous tissue in a subject, the method comprising incorporating a sound excitable compound into said cancerous tissue followed by exposure of said cancerous tissue to low-intensity ultrasound having an intensity of no more than 5 W/cm2, said sound excitable compound having the structure Formula (1) wherein: X1, X2, X3, and X4 are each independently selected from iodine and bromine atoms; X5, X6, X7, and X8 are each independently selected from hydrogen atom, chlorine, bromine, and iodine atoms; Y1 is an —O—, —NR′—, or —CR′2— linker, wherein R′ is independently selected from hydrogen atom and methyl; Z is a hydrocarbon linking group containing 1-12 carbon atoms; R1 is selected from hydrogen atom, methyl, —OH, and —OR groups, wherein R is an alkyl group containing one to three carbon atoms; and wherein said Formula (1) includes pharmaceutically acceptable salts and solvates of the compounds embraced by Formula (1).