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Mount Seir was named for Seir the Horite, whose offspring had previously inhabited the area (Genesis 14:6, 36:20). The children of Esau, the Edomites, battled against the Horites and destroyed them (Book of Deuteronomy, ). Mount Seir is specifically noted as the place where Esau made his home (Book of Genesis 32:3; 33:14, 16; 36:8; Joshua 24:4).