Yazid ibn al-Muhallab
After his dismissal from Mecca, he is next mentioned as one of the two envoys sent by Caliph Yazid II () to the former governor of Iraq, Yazid ibn al-Muhallab, hoping to prevent his rebellion. In 724, on the accession of Hisham ibn Abd al-Malik (), Khalid was himself appointed as governor of Iraq, replacing Umar ibn Hubayra. His authority extended over the entire eastern Caliphate, except for Khurasan, which was sometimes separated from Iraq's authority. When Khurasan was under his jurisdiction, he appointed his brother, Asad, to its governorship (725–727 and 734–738).