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This is a list of characters that appeared on the American animated television series franchise The Powerpuff Girls on the Cartoon Network. All of the characters on this list appear more than once in the series and contribute to the episode plotlines. The titular Powerpuff Girls are named Blossom, Bubbles, Buttercup, and Bliss, and appear in the 1998 "The Powerpuff Girls" series, the 2006 "Powerpuff Girls Z" series and the 2016 "The Powerpuff Girls" series. TV Guide chose the Powerpuff Girls as No. 13 in a list of the 50 Greatest cartoon characters of all time.