Albert Anastasia
In 1957, Persico allegedly participated in the murder of Albert Anastasia, the former leader of Murder, Inc. and the boss of what was then the Anastasia family. Anastasia's underboss Carlo Gambino wanted control of the family and conspired with his allies, Genovese family boss Vito Genovese and Profaci boss Joe Profaci, to kill Anastasia. Profaci allegedly gave the job to Persico and the Gallo brothers.