Positron emission tomography
Sieve estimators have been used extensively for estimating density functions in high-dimensional spaces such as in Positron emission tomography(PET). The first exploitation of Sieves in PET for solving the maximum-likelihood Positron emission tomography#Image reconstruction problem was by Donald Snyder and Michael Miller, where they stabilized the time-of-flight PET problem originally solved by Shepp and Vardi.