Andronikos I Komnenos
Euphrosyne was the daughter of Andronikos Kamateros, a high-ranking official who held the titles of "megas droungarios" and "pansebastos" and wife, an unknown Kantakouzene. She was related to the Emperor Constantine X and Irene Doukaina, empress of Alexios I Komnenos. Both of her brothers had rebelled against Andronikos I Komnenos; one was imprisoned and the other was blinded.