Cuenca, Spain
The Spanish settlement of Cuenca was founded on April 12, 1557 by the explorer Gil Ramírez Dávalos. Andrés Hurtado de Mendoza, then Viceroy of Peru had commissioned the founding and ordered the city named after his home town of Cuenca, Spain. It was founded decades after other major Spanish settlements in the region, such as Quito (1534), Guayaquil (1538), and Loja (1548).