وقعة صفين
During the Sasanian period, population of al-Mada'in was heavily mixed, it included Arameans, Persians, Greeks, and Assyrians. Several religions were also practiced in the metropolis, which included Christianity, Judaism, and Zoroastrianism. The population also included Manicheans, who continued to be mentioned in al-Mada'in during Umayyad rule. Much of the population fled from al-Mada'in after the Arab capture of the metropolis. However, a portion of Persians remained there, and some important figures of these people are known to have provided Ali with presents, which he, however, refused to take. After the Battle of Siffin, the Persian population of al-Mada'in disappeared.