三好氏
The clan supported the 14th shogun Yoshihide ASHIKAGA from the home ground of Awa. But in 1568 when Nobunaga ODA entered the capital Kyoto under the 15th shogun Yoshiaki ASHIKAGA, Miyoshi clan did not have the strength to hold out against Oda clan. Miyoshi clan challenged Oda to a decisive battle but lost easily, and some of the clan fled to their home ground Awa, and others had to go on as the vassals of Nobunaga. Later when the shogun Yoshiaki conflicted with Nobunaga and the anti-Nobunaga network was laid, Yoshitsugu and sanninshu took Yoshiaki's side and conflicted with Nobunaga. However, they did not have the strength to hold out against the Oda clan's powerful military power. In 1573, when he was attacked by Nobumori SAKUMA, one of the Nobunaga's vassals, Yoshitsugu killed himself and the head family of Miyoshi clan died out. But in Awa Province in Shikoku, Nagaharu MIYOSHI who had succeeded Yoshikata MIYOSHI and his real brother Masayasu SOGO still exerted their influence in eastern part of Shikoku. However, after Nagaharu killed his loyal vassal Nagafusa SHINOHARA, believing the slanders, the vassals of Nagaharu became anxious and defected from Miyoshi clan. Later Nagaharu was killed by his vassal acquainted with Motochika CHOSOKABE in Tosa Province. It is not an exaggeration to say that Miyoshi clan as a Sengoku daimyo died out by this incident.