会津戦争
During the Boshin War, the domain was one of the first in Shinano to side with the imperial cause, and sent forces to fight in the Battle of Hokuetsu and Battle of Aizu. In July 1871, with the abolition of the han system, Matsushiro Domain briefly became Matsushiro Prefecture, and was merged into the newly created Nagano Prefecture. Under the new Meiji government, Sanada Yukimoto, the last daimyo of Matsushiro Domain was given the "kazoku" peerage title of "shishaku" (viscount), and was later elevated to "hakushaku" (count).