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In 1909, Wu's father was framed by his boss for “embezzling public funds”. In distress over the lost funds, he committed suicide by throwing himself into a river. Wu Yi-fang left her school, and the following year, she and her family moved to her mother's hometown in Hangzhou, relying on relatives to support them. After a year, they moved again to Shanghai with Wu's uncle, Chen Shu-tong () and his family. On October 10, 1911, the XinHai Revolution broke out. Without hope of emigrating out of the country to escape the many uprisings and revolts at the time, her brother, Wu Yi-chu () committed suicide by jumping into a river. Exacerbated by the deaths of her husband and her son, Wu's mother, who had fallen ill, died shortly after. The night before her mother's funeral, Wu's sister, Wu Yi-fen () hung herself in despair. At the age of 19, Wu's brother, mother, and sister had died, all within a month.