Mehmed III
Of Bosnian origin, Handan Sultan was a servant in the household of Cerrah Mehmed Pasha, the Beylerbey of the Rumelia Eyalet. He was the husband of Gevherhan Sultan, daughter of Sultan Selim II, sister of Sultan Murad III, and aunt of Sultan Mehmed III. Mehmed Pasha was a surgeon ("cerrah") and had circumcised Prince Mehmed in 1582.