Isra and Mi'raj
According to Seyyed Hossein Nasr, professor of Islamic Studies at George Washington University, Jerusalem (i.e., the Temple Mount) has the significance as a holy site/sanctuary ("haram") for Muslims primarily in three ways, the first two being connected to the Temple. First, Muhammad (and his companions) prayed facing the Temple in Jerusalem (referred to as "Bayt Al-Maqdis", in the Hadiths) similar to the Jews before changing it to the Kaaba in Mecca sixteen months after arriving in Medina following the verses revealed (Sura 2:144, 149–150). Secondly, during the Meccan part of his life, he reported to have been to Jerusalem by night and prayed in the Temple, as the first part of his otherworldly journey (Isra and Mi'raj).