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Cao Mao was a son of Cao Lin, the Prince of Donghai (東海王), a son of Cao Pi. In 244, at the age of three, in accordance with Wei's regulations that the sons of princes (other than the first-born son of the prince's wife, customarily designated as the prince's heir) were to be instated as dukes, Cao Mao was enfeoffed as the "Duke of Gaogui District" (高貴鄉公). Cao Lin died in 249 when Cao Mao was eight. Cao Mao's elder brother, Cao Qi (曹啟), succeeded their father as the Prince of Donghai.