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Hans Sloane was born on 14 November 1739 at South Stoneham, Hampshire. He was educated at Newcome's School, Trinity College, Cambridge and the Inner Temple. He was the great-nephew of noted physician and collector Sir Hans Sloane, Bart., and first cousin of John 'Mad Jack' Fuller, who was also a Member of Parliament for Southampton in 1780. Another relative was Hans Stanley, grandson of Sir Hans Sloane, who guided his early career.