スコット・ローレン
The Astros scored three runs off Cardinals' Matt Morris on home runs by Carlos Beltran in the first and Morgan Ensberg in the fourth. Lance Berkman added an RBI single in the fifth with two on, but in the bottom of the inning, two-run home runs from Larry Walker off starter Peter Munro and Scott Rolen off reliever Chad Harville put the Cardinals up 4−3. The Astros tied it in the seventh off Kiko Calero when Berkman hit a leadoff double, stole third and scored on Ensberg's single, but the Cardinals retook the lead in the bottom of the eighth inning with back-to-back home runs from Albert Pujols and Scott Rolen off Dan Miceli. Jason Isringhausen pitched a scoreless ninth despite allowing two walks as the Cardinals' 6−4 win put them up 2−0 in the series heading to Houston.