Macedonian Wars
After Alexander's death in 323BC, the ensuing wars of the Diadochi, and the partitioning of Alexander's short-lived empire, Macedonia remained a Greek cultural and political center in the Mediterranean region along with Ptolemaic Egypt, the Seleucid Empire, and the Kingdom of Pergamon. Important cities such as Pella, Pydna, and Amphipolis were involved in power struggles for control of the territory. New cities were founded, such as Thessalonica by the usurper Cassander (named after his wife Thessalonike of Macedon). Macedonia's decline began with the Macedonian Wars and the rise of Rome as the leading Mediterranean power. At the end of the Third Macedonian War in 168BC, the Macedonian monarchy was abolished and replaced by Roman client states. A short-lived revival of the monarchy during the Fourth Macedonian War in 150–148BC ended with the establishment of the Roman province of Macedonia.