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The Ernest and Eugenia Wyatt Guest House is located next to the old Ellis Fischel Cancer Center on Business Loop 70. The Guest House is available for EFCC patients experiencing long-term outpatient care, such as chemotherapy, and families of EFCC inpatients. The house has twelve rooms available for guest use, with each room equipped with two double beds, private bath, telephone, TV, linens and other "hotel like" amenities. Common areas include the kitchen, TV rooms, library, living room, internet and laundry facilities. The Wyatt Guest house was later closed in June of 2020.