H. John Heinz III
Democrat Harris Wofford was appointed to the Senate when three-term Republican H. John Heinz III died in a 1991 plane crash. He won a special election to hold that seat later that year. In his tough re-election against Republican Congressman Rick Santorum, the pro-choice Wofford lost the endorsement of pro-life Democratic Governor Robert Casey. This contributed to his loss to Santorum by two percentage points.