Derby d'Italia
Three days after that, he made his debut for "Nerazzurri" in the "Derby d'Italia" against Juventus at Juventus Stadium, a 3–1 Inter loss. On 15 March, D'Ambrosio started his first match with Inter, defeating Hellas Verona 2–0 at the Stadio Marc'Antonio Bentegodi. Following that result, he secured a place in the starting lineup. D'Ambrosio was an unused substitute in Javier Zanetti's last competitive match at the San Siro, in which Inter defeated Lazio 4–1 to secure a place in UEFA Europa League play-off for next season. D'Ambrosio finished his first season with Inter having played 11 matches, 3 of which he played in their entirety.