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In 1733, on the recommendation of Hans Sloane, he was appointed librarian to the Royal College of Physicians in London. Sir Hans Sloane, founder of the British Museum, had employed George Edwards as a natural history painter for many years, and Edwards drew miniature figures of animals for him. Edwards visited Sloane once a week to share news and a coffee. Sloane kept track of Edwards's expenses and reimbursed him annually. Edwards served as College librarian for thirty-six years. He was chosen Fellow of the Royal Society and of the London Society of Antiquaries and was rewarded with the Copley Medal.