Tranexamic acid
Based on evidence from people with other health problems crystalloid and colloids are believed to be equivalent for peptic ulcer bleeding. In people with a confirmed peptic ulcer, proton pump inhibitors do not reduce death rates, later bleeding events, or need for surgery. They may decrease signs of bleeding at endoscopy however. In those with less severe disease and where endoscopy is rapidly available, they are of less immediate clinical importance. Tranexamic acid might be effective to reduce mortality, but the evidence for this is weak. But the evidence is promising. Somatostatin and octreotide while recommended for variceal bleeding have not been found to be of general use for non-variceal bleeds.