Cao Rui
Guo Nüwang did not bear Cao Pi any children. Cao Rui was the eldest of Cao Pi's sons, but because of his mother's death, he was not instated as the crown prince. Instead, Cao Rui was appointed "Prince of Pingyuan" after his father's ascension to the throne. Cao Pi did not appear to have seriously considered any other son as heir. (It might have been because the other sons were all significantly younger, although their ages were not recorded in history.) In the summer of 226, when Cao Pi was seriously ill, he finally named Cao Rui as his crown prince. On his deathbed, he entrusted Cao Rui to the care of Cao Zhen, Chen Qun and Sima Yi. Following his father's death, Cao Rui ascended the throne at the age of 21.