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After Liu Bei's death in 223, Wu Yi continued serving under Liu Bei's son and successor, Liu Shan. In 230, he followed the Shu general Wei Yan to attack Nan'an Commandery (南安郡; southeast of present-day Longxi County, Gansu), which was under the control of Shu's rival state, Wei. They defeated Wei forces led by Fei Yao in the battle. In recognition of Wu Yi's contributions, Liu Shan first enfeoffed Wu Yi as a village marquis (亭侯), but promoted him to a district marquis later under the title "Marquis of Gaoyang District" (高陽鄉侯). He also appointed Wu Yi as General of the Left (左將軍).