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In 2010 he won his first classic of the year, April's Amstel Gold Race. After an aggressive race featuring many attacks, he won through a big attack in the last of the climb to the finish, comfortably winning by several bike lengths from the peloton. He also won the first stage of the Tour of Belgium. Gilbert then ended the 2010 season in superb form. He followed up two stage wins in the Vuelta a España with victories in the Giro del Piemonte and the Giro di Lombardia, repeating his 2009 wins in both races. The Giro di Lombardia was won with a solo attack in atrocious weather conditions.