Interleague play
The Astros struggled in April. After starting the season 0–8, they finished April 8–14, despite a 3.92 ERA from their pitching staff. They lost the last four in April, as well as the first four in May for a second 8-game losing streak. They finished May with a 9–20 mark to give the Astros a 17–34 record over the first two months. The Astros rebounded to win 8 of their first 10 games in June, but struggled in Interleague play, going 2–10 against the AL in June to finish 14–14 in June.