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She is the voice of Daisy Duck and Wilma Flintstone since 1999 and 2000 respectively. MacNeille also appeared as an angry anchorwoman in "Elvira, Mistress of the Dark" and served as the voice of Elvira's Great-Aunt Morganna Talbot. She provided voice acting for the 2003 Wile E. Coyote and the Road Runner short feature "The Whizzard of Ow".