Frosinone Calcio
Paganini is a youth exponent from Frosinone Calcio. He made his first team debut on 18 December 2011 against U.S. Siracusa in a Lega Pro Prima Divisione game. He came in as an 89th-minute substitute for Fabio Catacchini in a 1-0 away defeat. He was loaned out to Fondi for six months from January 2013 until June 2013. He scored his first Serie A goal on 18 October 2015 with Frosinone after a 2–0 defeat of Sampdoria.