فخر الدين المعني الثاني
Syria became part of the Ottoman Empire in 1516, and Palmyra was a center of an administrative district (sanjak). After 1568 the Ottomans appointed the Lebanese prince Ali bin Musa Harfush as governor of Palmyra's sanjak, dismissing him in 1584 for treason. In 1630 Palmyra came under the authority of another Lebanese prince, Fakhr-al-Din II, who renovated Shirkuh II's castle (which became known as Fakhr-al-Din al-Maani Castle). The prince fell from grace with the Ottomans in 1633 and lost control of the village, which remained a separate sanjak until it was absorbed by Zor Sanjak in 1857. The Ottoman governor of Syria, Mehmed Rashid Pasha, established a garrison in the village to control the Bedouin in 1867.