El Tanque Sisley
Sixteen teams will compete in the Primera División this season. Thirteen teams remained from the 2009–10 season. Atenas, Cerrito, and Cerro Largo were relegated after accumulating the fewest points in the season aggregate table. They were replaced by El Tanque Sisley, Bella Vista, and Miramar Misiones, the 2009–10 Segunda División winner, runner-up, and playoff winner, respectively. All of the new teams are making repeat appearances. All the teams in this season are from Montevideo, except Tacuarembó F.C., who comes from the city they are named for.