Shar Pei
Familial Shar Pei fever (FSF) is a serious congenital disease that causes short fevers lasting from 24 hours to sometimes up to three days and usually accompanied by accumulation of fluid around the ankles (called Swollen Hock Syndrome). Amyloidosis, a long-term condition, is most likely related to FSF, caused by unprocessed amyloid proteins depositing in the organs, most often in the kidneys or liver, leading eventually to kidney failure. The disease is associated with the Western type and it is estimated that 23% are affected. The Australian breed standard was changed in 2009 to discourage breeding for heavy wrinkling.