Street Fighter
Despite not appearing until the release of "Street Fighter II", Bison is widely considered to be the true main antagonist of the "Street Fighter" series, having filled the role in the "Street Fighter II" and "Street Fighter Alpha" series and "Street Fighter V" and acting as the force behind the events of the "Street Fighter IV" series, where the main villain, Seth, is revealed to have been Bison's unwitting pawn all along.