Mithridatic Wars
Anatolia came under Roman rule entirely following the Mithridatic Wars of 88–63 BC. Roman control of Anatolia was strengthened by a 'hands off' approach by Rome, allowing local control to govern effectively and providing military protection. In the early 4th century, Constantine the Great established a new administrative centre at Constantinople, and by the end of the 4th century a new eastern empire was established with Constantinople as its capital, referred to by historians as the Byzantine Empire from the original name, Byzantium.