ウィッティヒ反応
K. C. Nicolaou and coworkers at Scripps Research Institute generated the chiral hydrazone through Enders' hydrazone alkylation reaction with high stereoselectivity ("de" &gt; 95%). The subsequent ozonolysis and Wittig reaction led to the side chain fragment of zaragozic acid A, which is a potent medicine for coronary heart disease.