Spacing Guild
At the end of "Dune Messiah", Paul Atreides walks into the desert, a blind man, leaving his twin children Leto and Ghanima in the care of the Fremen, while his sister Alia rules the universe as regent. Awakened in the womb by the spice, the children are the heirs to Paul's prescient vision of the fate of the universe, a role that Alia desperately craves. House Corrino schemes to return to the throne, while the Bene Gesserit make common cause with the Tleilaxu and Spacing Guild to gain control of the spice and the children of Paul Atreides.