ジョー・ソーンダース
On April 30, 2008, Santana equaled an Angels record with a 5–0 start to the season. He joined Angels legend Frank Tanana and teammate Joe Saunders, who equaled Tanana the day before. Santana was 11–3 with a 3.34 ERA at the All-Star Break. Pitching in the 2008 MLB All-Star Game, Santana gave up a fifth inning homer to Matt Holliday of the Colorado Rockies.