日本貨物航空
Cargolux and Nippon Cargo Airlines were the first customers for the , placing orders for the freighter variant in November 2005. The firm configuration of the aircraft was finalized in October 2006. Major assembly of the aircraft began on August 8, 2008, and the aircraft first left Boeing's Everett factory on November 12, 2009. The first aircraft was delivered on October 12, 2011, to Cargolux. At its six-month service mark, Boeing announced that initial 747-8F operators had achieved a 1-percent reduction in fuel burn over projections.