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Pfister was highly successful during his time at Zamalek SC. During his time as head coach (1999–2002) Pfister won an impressive five trophies. On 10 December 2000, Zamalek recorded a convincing 4–3 aggregate score in the second-leg final against Canon Yaoundé in the African Cup Winners' Cup (now the Confederations Cup). The first and last time this trophy would be won by the Egyptian club. Pfister led Zamalek for their worst defeat against rivals Al Ahly 6–1 on 16 May 2002, Zamalek also reached the final of the CAF Super Cup, losing 2–0 to Accra Hearts of Oak SC.