المملكة المصرية الوسطى
"Drimia maritima", the sea squill, has been used as a medicinal plant since ancient times. Its use for treatment of edema is mentioned in a papyrus from 1554 BC, the Middle Kingdom of Egypt. Bufadienolides isolated from "Drimia maritima" and "Drimia indica" are used for the production of substances for the treatment of heart conditions.