Tigres de Quintana Roo
On June 10, 2016, Asencio signed with the Tigres de Quintana Roo of the Mexican League. In 56 games to finish out the year, Asencio slashed .308/.338/.488 with 6 home runs and 43 RBI. He became a free agent from the Tigres de Quintana Roo after the 2016 season.