AFC西地区
The Rams travel to San Diego, facing their third AFC West opponent, the Chargers. The Rams looked to go 2-1 against AFC West opponents, but couldn't flick the switch this time thanks to the Chargers' Philip Rivers' late game heroics and the defense, who intercepted a pass from Shaun Hill, who attempted a game-winning touchdown pass. With the 27-24 loss, this gave the Rams a 1-2 record against all AFC West opponents. Rams fans, who attended the game, were seen holding up signs involving a possible return to Los Angeles.