先發投手
Starting pitcher Casey Kelly, obtained in the 2010 trade of Adrián González to the Boston Red Sox, made his major league debut with San Diego on August 27, 2012. Kelly earned a win after pitching six shutout innings in a 3–0 victory over the Atlanta Braves. He also recorded his first major league hit in the game. Kelly was the 15th different starting pitcher used by the Padres in 2012, which matched a club record set in 2002 and tied in 2009. The Padres ended the season with 24 pitchers throwing at least 15 innings.