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Former Secretary of State Cordell Hull (1871–1955)— who played a pivotal role in the creation of the United Nations— was born just west of Byrdstown. The Pickett County Courthouse, built in 1935, and the Cordell Hull Birthplace are both listed on the National Register of Historic Places. Other historical sites include the Amonett House at the junction of TN-325 and TN-111.