Frosinone Calcio
On 30 June 2013 he was signed by Frosinone Calcio in co-ownership deal, swapped with Leandro Campagna. Both 50% registration rights of the players were tagged for €600,000. On 24 January 2014 Frosinone signed Ciofani outright. He scored his first goal in Serie A for the club on 28 October 2015 in a 2–1 win over Carpi.