Francis, Duke of Guise
When the first War of Religion broke out, he was among the first to join Louis I de Bourbon, prince de Condé, named leader of the Protestant faction. François's position as colonel-général was confiscated and re-allocated to the duc de Randari. Despite suffering from a fever at the time, he fought at the battle of Dreux in 1562. The following year, he defended Orléans when it was besieged by the troops of Francis, Duke of Guise. The siege was only raised when the Duke was assassinated.