松井稼頭央
The Astros opened up their season in San Diego without second baseman Kazuo Matsui. Matsui, who had been injured in Spring training was completing a Minor League rehab assignment. The game that day was bad for Houston because Roy Oswalt gave up four runs in six innings of work. The final was 4–0, Padres. Also the Astros lost the second game of the series with Mark Loretta and Geoff Blum also starting.