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"Cissus subaphylla" is one of the dominant plant species found on the Socotra's coastal plains and low inland mountains. It grows in particular association with "Salvadora persica" and "Croton socotranus", but is also found with "Jatropha unicostata", "Pulicaria stephanocarpa", "Dendrosicyos socotranus", and "Adenium obesum". subsp. sokotranum. About 270 of the island's 828 known plant species are endemic.