サウスカロライナ植民地
Henry Middleton was born in 1717 on the family plantation, "The Oaks", near Charleston, Province of South Carolina. He was the second son of Susan (née Amory) Middleton (1690-1722) and Arthur Middleton (1681–1737), a wealthy planter who had served as an acting governor of South Carolina. His grandfather, Edward Middleton, emigrated from England via Barbados.