Meng Huo
Liu Bei proceeds to campaign in the southlands to get rid of Wu's threat, as Wu had backed a Nanman rebellion by King Meng Huo. In Nanzhong, he systematically defeated Meng Huo for a total of seven times, as Zhuge Liang cleverly resisted the Nanman armor troops and also pacified the poison marshes. After taking down Meng Huo, Shu proceeded to capture Fan Castle from Wei's Cao Ren, and also defeated Wu reinforcements under Lu Meng and traitors under Mi Fang and Fu Shiren. The final battle with Wu was at the Battle of Yi Ling, where Liu Bei braved a Wu fire attack and defeated (if Wu falls first, kills) Sun Jian and his officers. If Wei has been defeated before Wu, Liu Bei proceeds to attack Jianye, and sees through Sun Jian's body double trickery and kills Sun Jian, Sun Ce, Sun Quan, and Sun Shangxiang.