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Pyrazinamide is only used in combination with other drugs such as isoniazid and rifampicin in the treatment of "Mycobacterium tuberculosis" and as directly observed therapy (DOT). It is never used on its own. It has no other indicated medical uses. In particular, it is not used to treat other mycobacteria; "Mycobacterium bovis" and "Mycobacterium leprae" are innately resistant to pyrazinamide.