Fall of the Western Roman Empire
As the Christian religion spread throughout the Roman and Persian Empires, it took root in the Middle East, and cities such as Alexandria and Edessa became important centers of Christian scholarship. By the 5th century, Christianity was the dominant religion in the Middle East, with other faiths (gradually including "heretical" Christian sects) being actively repressed. The Middle East's ties to the city of Rome were gradually severed as the Empire split into East and West, with the Middle East tied to the new Roman capital of Constantinople. The subsequent Fall of the Western Roman Empire therefore, had minimal direct impact on the region.