Château de Blois
Louise Marguerite was born at the "Château de Blois", present at Blois outside Paris. Her father was Henri of Lorraine, Duke of Guise, member of the House of Lorraine and her mother was Catherine of Cleves. She was the penultimate child of fourteen; her brother Claude, Duke of Chevreuse was the husband of Marie de Rohan, the infamous Frondeur. Her oldest brother Charles was the last Duke of Guise after the death of her father in 1588.