Nihonmatsu Domain
Karasuyama was briefly ruled by the Matsushita clan from 1623–1627, before their transfer to Nihonmatsu Domain. From 1627–1672, the Hori clan ruled Karasuyama, during which time they made extensive renovations to the castle and surrounding castle town. They were followed briefly by a branch of the Itakura clan (1672–1681) and then the Nasu clan (1682-1687). However, the Nasu were dispossessed by "Shōgun" Tokugawa Tsunayoshi following a succession dispute, and were replaced by Nagai Naohiro (1687–1701), who later was transferred to Ako Domain after its confiscation from Asano Naganori following the Forty-seven "rōnin" incident. A junior branch of the Itakura clan then ruled Karasuyama from 1701–1725.