Trail running
What is now Route 53 was once part of a Lenape Trail running from Morristown to Denville. In 1916, present-day Route 53 was designated as part of pre-1927 Route 5, which ran from Delaware in Warren County east to Newark. In the 1927 New Jersey state highway renumbering, this route became Route 6 (now U.S. Route 46) between Delaware and Denville, Route 32 (now U.S. Route 202) between Morris Plains and Morristown, and Route 24 (now Route 124) between Morristown and Newark. The portion of pre-1927 Route 5 between Morris Plains and Denville, however, was not replaced by a different route and became Route 5N to distinguish it from a newly created Route 5. The northern terminus of Route 5N was at U.S. Route 46/Route 6 (Bloomfield Avenue) in Denville; when those routes were moved to a bypass, Route 5N's northern terminus remained at Bloomfield Avenue. In the 1953 New Jersey state highway renumbering, Route 5N was renumbered to Route 53.