T helper cell
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier "et al." who isolated IL17A transcript from a rodent T-cell hybridoma. The protein encoded by "IL17A" is a founding member of IL-17 family (see below). IL17A protein exhibits a high homology with a viral IL-17-like protein () encoded in the genome of T-lymphotropic rhadinovirus "Herpesvirus saimiri". In rodents, IL-17A is often referred to as CTLA8.