Protein C
Protein C inhibitors have ability to inhibit protein C, thrombin and other enzymes that are stimulated by heparin. The heparin binding site of protein C inhibitor is from 264-283 region. Heparin enhances the rate of inhibition leading to the conformational change in the structure of Protein C and other proteases. The binding site of heparin is different for protein C inhibitor and other proteases Heparin regulates the protein C inhibitor (PCI) activity and furthermore its specificity in those system where there is presence of two or more target proteases.