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Medina began his career illustrating such titles as "Berserker" and "Megaton" at Megaton Comics. He subsequently worked for First Publishing, on such titles as "Dreadstar" and "Hammer Of God" in the late 1980s, before starting to work for Marvel Comics on "The Incredible Hulk", "Warlock and the Infinity Watch", "Blackwulf", "Avengers", "The Amazing Spider-Man", and "Marvel Knights Spider-Man".