Red blood cell
Dogs who were orally exposed to 0, 0.5, 3, 5, 15 or 75 ppm (equivalent to 0–3.07 mg/kg/day) for 13 weeks, ate less and lost weight. The plasma cholinesterase activity was already affected by a sulfotep concentration of 3 ppm (or higher). Red blood cell-acetylcholinesterase was decreased at 75 ppm. Diarrhea and vomiting occasionally occurred at 15 ppm, but were common at 75 ppm. The brain cholinesterase activity was unaffected.