Johann Wilhelm, Elector Palatine
It is unknown whether Ruysch was a member of the Amsterdam Guild of Saint Luke, but early signed works by her in the 1680s show the influence of Otto Marseus van Schrieck. By 1699 she and her family had moved to The Hague, where she was offered membership in the Confrerie Pictura as their first female member. In 1701 she and her husband became members of The Hague Painter's Guild. In 1708, Ruysch was invited to work for the court in Düsseldorf and serve as court painter to Johann Wilhelm, Elector Palatine. She obtained a contract for works painted at home that she periodically brought to Düsseldorf. She continued working for him and his wife from 1708 until the prince's death in 1716.