ココ・ソロ
After training exercises off southern New England, "S-46" sailed for the Panama Canal Zone to join Submarine Division 19 (SubDiv 19). Arriving at Coco Solo on 26 September, she commenced a schedule of local operations from Coco Solo and Balboa, Panama, which were interrupted only for semi-annual extended training cruises and annual fleet problems in the Caribbean Sea and Pacific Ocean. Repairs and overhauls were performed at Balboa.