Herpes simplex virus
Notholaenic acid is a dihydrostilbenoid found in the farina of some ferns of the genus "Notholaena". It has been shown to have anti-HSV-1 (Herpes simplex virus 1) activity at high concentrations "in vitro". It was artificially synthesized, starting from 3-benzyloxy-5-methoxybenzyl alcohol, in 1985.