Doctor Octopus
In a prelude to the "Sinister War" storyline, Doctor Octopus coerces Dr. Curt Connors into using the Isotope Particle Accelerator on himself which separates Lizard from Dr. Connors. While in the Osborn Graveyard, Doctor Octopus demands that Kindred gives him the answers he seeks. Kindred states to Doctor Octopus that he'll get the answers soon as he adds Mysterio to the latest incarnation to the Sinister Six.