Ghana national football team
Opoku's first call up for the Ghana national football team was for a friendly match against Argentina national football team, and Opoku earned his debut in the match on 1 October 2009. In November 2013, coach Maxwell Konadu invited Opoku to be a part of the Ghana national football team squad for the 2013 WAFU Nations Cup. Opoku helped the Ghana national football team to a first-place finish after Ghana national football team beat Senegal national football team by three goals to one.