Amy Rose
The "Sonic the Hedgehog" video game franchise began in 1991 with the game "Sonic the Hedgehog" for the Sega Genesis, which pitted a blue anthropomorphic hedgehog named Sonic against a rotund male human villain named Doctor Eggman (or Doctor Ivo Robotnik). The sequel, "Sonic 2", gave Sonic a fox friend named Tails. "Sonic CD" introduced Amy Rose, a female hedgehog with a persistent crush on Sonic. "Sonic 3" introduced Knuckles the Echidna, Sonic's rival and, later, friend. All five of these have remained major characters and appeared in dozens of games.