酸化ストレス
Oxidative stress and oxidative damage in the SNpc are likely key drivers in the etiology of Parkinson’s disease as individuals age. DNA damages caused by oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed in the substantia nigra, but its DNA repair function appears to be compromised in Lewy body inclusion bearing neurons. This loss may trigger cell death.