同盟規約
In the mid-1770s, with growing tensions between Britain and its American colonies, Lopez's fortunes began to decline. The Continental Association enforced a boycott against trade with Britain. In October 1775, the British navy anchored outside Newport's harbour and the population began to evacuate the city. In early 1776 Lopez relocated to Portsmouth, Rhode Island, then to Providence, Boston, and finally to Leicester, Massachusetts. Historian Marilyn Kaplan describes Lopez's losses during the American Revolution as "monumental."