Interleague play
Looking to rebound from their 12-game losing streak in May, the Royals started the month of June with 4 consecutive series wins over National League opponents. Kansas City completed its first ever series sweep of the Cardinals in St. Louis. In 12 years of Interleague play, the Cardinals still hold the I-70 Series lead, 26-22, but the Royals have done better in St. Louis, winning 11 of 21 games. On June 22, the Royals made an improbable comeback after trailing 6-0 and later 10-3 against the San Francisco Giants. The Royals scored 8 unanswered runs and won the game and Joakim Soria recorded his 20th save of the season in 21 tries. Following a sweep of the defending National League champion Colorado Rockies, the Royals boasted an MLB-best 12–3 record in Interleague play and won for the tenth time in 11 games. Following their 12-game skid ended in May, the Royals went 15–9, closed to within seven games of .500 and skipped out of last place of the American League Central.