Battle of Gaugamela
After the Battle of Gaugamela (331 BC), Orontes III was able to regain independence for Armenia. But in 201 BC, Armenia was conquered by Artashes, a general from the Seleucid Empire, and also said to be a member of Orontid dynasty. The last Orontid king Orontes IV was killed, but the Orontids continued to rule in Sophene and Commagene until the 1st century BC.