Spacing Guild
In "Dune Messiah", the Reverend Mother joins the conspiracy to topple the rule of Paul Atreides after he ascends the Golden Lion Throne and unleashes his Jihad upon the Empire. She, along with the Tleilaxu Face Dancer Scytale, the Spacing Guild Navigator Edric, and Paul's embittered consort (and Shaddam's daughter) Princess Irulan of House Corrino, plot to insinuate the Tleilaxu ghola Hayt into the court to weaken Paul's confidence in his prescience and thereby ruin him.