安德洛尼卡一世
Under Andronikos I Komnenos (r. 1183–1185), Makrodoukas initially enjoyed the emperor's favour, and rose to the rank of "panhypersebastos". However, after the rebellion of Makrodoukas' nephew Isaac Komnenos, who declared himself emperor in Cyprus, he was arrested along with other relatives of the rebel, accused of treason and condemned on 30 May to death by stoning. After surviving the stoning, he was dragged to Mangana, where he was dismembered.