Charles Emmanuel I, Duke of Savoy
Botero's life took a major turn at this time, when he was commissioned by Bishop Carlo Borromeo of Milan as a personal assistant. Borromeo introduced Botero to the practical side of Church administration, often socializing with the nobility of northern Italy, most notably Charles Emmanuel I, Duke of Savoy. When the Bishop died in 1584, Botero continued his service to the family as assistant to Carlo Borromeo's nephew, Federico.