معركة مرج دابق
Masyaf, along with the rest of Syria, was incorporated into the Ottoman Empire in 1516–17 following the Ottoman victory over the Mamluks at the Battle of Marj Dabiq. Masyaf became a part of the "liwa" (district) of Homs, and along with the other Ismaili fortresses in its vicinity ("qala' al-da'wa"), was responsible for paying a special tax. The town had a "khan" (caravanserai) which paid tolls to the Ottoman authorities. The tolls were abolished later in the mid-16th century. According to the Sufi traveler Abd al-Ghani al-Nabulsi, the "emir" of Masyaf in the early 1690s was a descendant of the Arab Tanukh tribe named Sulayman.