Antiochus IV Epiphanes
For a while during the rule of Antiochus IV Epiphanes (175–164 BCE) the city was named "Callirrhoe" or "Antiochia on the Callirhoe" (). During Byzantine rule it was named "Justinopolis". Prior to Turkish rule, it was often best known by the name given it by the Seleucids, , "Édessa".