Seleucus II Callinicus
In the Orontes, north of the city, lay a large island, and on this Seleucus II Callinicus began a third walled "city", which was finished by Antiochus III the Great. A fourth and last quarter was added by Antiochus IV Epiphanes (175–164 BC); thenceforth Antioch was known as "Tetrapolis". From west to east the whole was about in diameter and a little less from north to south. This area included many large gardens.