Joseph Bonanno
Profaci's brother was Salvatore Profaci, who served as his consigliere for years, and is known to have been heavily into dealing of pornographic materials. One of Profaci's brothers-in-law was Joseph Magliocco, who would eventually become Profaci's underboss. Profaci's niece Rosalie Profaci was married to Salvatore Bonanno, the son of Bonanno crime family boss Joseph Bonanno. Profaci was the uncle of Salvatore Profaci Jr., also a member of the Profaci crime family.