Attalid dynasty
The town was the most important center in ancient North Lydia. Findings suggest a possible earlier period of pre-eminence under the Hittites. Persian occupation of the region took place around 500 BC. Thyateira was later conquered by Alexander the Great. In later years, Thyateira was captured successively by the Seleucid Empire, the Attalid dynasty of Pergamon, and by Mithridates VI of Pontus, until the Roman Era that started in 80 BC.