Donato Bramante
Donato Bramante painted a fresco known as "Democritus and Heraclitus" in Casa Panigarola, Milan, in 1477. Heraclitus's most famous depiction in art is in Raphael's "School of Athens", which was painted in around 1510. Raphael depicted Michelangelo as Heraclitus; he and Diogenes of Sinope are the only men to sit alone in the painting. Heraclitus seems to write a poem, though he also looks away from his pen and paper.