University of Karachi
He also taught as visiting professor at his alma mater Heidelberg University (1963–64), Columbia University (1964–65) and University of Pennsylvania (1965–66). In 1966, Mahmud Husain Khan went back to the University of Karachi as professor of history and worked there as the dean of its Faculty of Arts until 1971. He was appointed vice-chancellor of the University of Karachi from 1971 to 1975.