Masahiro Tanaka
Sisco received his first-ever promotion to the Orioles on September 1, 2017. He made his MLB debut the following night as a defensive replacement in the ninth inning of a 7–2 loss to the Toronto Blue Jays at Camden Yards. He achieved his first major league hit with a pinch-hit double off Masahiro Tanaka in the seventh, then followed it up with his first home run off Giovanny Gallegos in his subsequent plate appearance two innings later in a 13–5 defeat to the New York Yankees at Yankee Stadium on September 14.