Akron RubberDucks
On July 31, 2020, Cantillo was one of six players (along with Austin Hedges, Cal Quantrill, Josh Naylor, Gabriel Arias, and Owen Miller) sent to the Cleveland Indians in exchange for Mike Clevinger, Greg Allen, and Matt Waldron. He did not play a minor league game in 2020 due to the cancellation of the minor league season caused by the COVID-19 pandemic. To begin the 2021 season, he was assigned to the Akron RubberDucks of the Double-A Northeast League. On May 8, he was placed on the injured list with abdominal soreness.