Kell Brook
In his second title defence, Casimero faced Charlie Edwards, on September 10, 2016 on the undercard of Gennady Golovkin vs. Kell Brook. Casimero was on the offensive for most of the fight, as Edwards was unable to deal with Casimero's ring craft. Casimero upped the pace in the tenth round, and dropped Edwards with a left hook. Edwards beat the count, but as soon as he got up, Casimero unleashed a flurry of punches towards the challenger, which prompted the referee to end the fight immediately.