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Seleucus II oversaw the Third Syrian War (246–241 BC) with Berenice's brother, Ptolemy III Euergetes. In Asia Minor a rebellion by his younger brother Antiochus Hierax led to Seleucus II leaving the lands beyond the Taurus Mountains to him following a defeat at Ancyra in 236 BC, although the latter was eventually driven out of Anatolia by Pergamon in 227 BC.