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PPS treatment concerns comfort (relieving pain via analgesics) and rest (via use of mechanisms to make life easier, such as a powered wheelchair) and is generally of palliative care. No reversive therapies are known. Fatigue is usually the most disabling symptom. Energy conservation can significantly reduce fatigue episodes. Such can be achieved by lifestyle changes, such as additional (daytime) sleep, reducing workload, and weight loss for obesity. Some require lower-limb orthotics to reduce energy usage.