معركة مرج دابق
The prosperous period of Mamluk rule came to an end in 1516, when the Ottoman Turks conquered Syria from the Mamluks after defeating them at the Battle of Marj Dabiq near Aleppo. Hama, and the rest of Syria, came under Ottoman rule from Constantinople. Under the Ottomans, Hama gradually became more important in the administrative structure of the region. It was first made capital of one of the "liwas" ("districts") of the "vilayet" ("province") of Tripoli. Hama once again became an important center for trade routes running east from the Mediterranean coast into Asia. A number of "khans" ("caravansaries"s) were built in the city, like Khan Rustum Pasha which dates from 1556. Syria was later divided into three governorships and Hama was ruled by the governorship based at Aleppo.