马其顿战争
In the following years, Epirus faced the growing threat of the expansionist Roman Republic, which fought a series of wars with Macedonia. The League remained neutral in the first two Macedonian Wars but split in the Third Macedonian War (171–168 BC), with the Molossians siding with the Macedonians and the Chaonians and Thesprotians siding with Rome. The outcome was disastrous for Epirus; Molossia fell to Rome in 167 BC and 150,000 of its inhabitants were enslaved.