Lance Berkman
Melancon was traded along with Jimmy Paredes to the Houston Astros for Lance Berkman on July 31, 2010. For the rest of 2010 with the Astros, Melancon went 2–0 with a 3.12 ERA in 20 relief appearances. Overall in 2010 combined with two teams, Melancon made 22 total appearances going 2–0 with a 4.22 ERA.