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Honey bee products are used medicinally in apitherapy across Asia, Europe, Africa, Australia, and the Americas, despite the fact that the honey bee was not introduced to the Americas until the colonization by Spain and Portugal. They are by far the most common medical insect product both historically and currently, and the most frequently referenced of these is honey. It can be applied to skin to treat excessive scar tissue, rashes, and burns, and as an eye poultice to treat infection. Honey is taken for digestive problems and as a general health restorative. It is taken hot to treat colds, cough, throat infections, laryngitis, tuberculosis, and lung diseases. Apitoxin (honey bee venom) is applied via direct stings to relieve arthritis, rheumatism, polyneuritis, and asthma. Propolis, a resinous, waxy mixture collected by honeybees and used as a hive insulator and sealant, is often consumed by menopausal women because of its high hormone content, and it is said to have antibiotic, anesthetic, and anti-inflammatory properties. Royal jelly is used to treat anaemia, gastrointestinal ulcers, arteriosclerosis, hypo- and hypertension, and inhibition of sexual libido. Finally bee bread, or bee pollen, is eaten as a generally health restorative, and is said to help treat both internal and external infections. One of the major peptides in bee venom, melittin, has the potential to treat inflammation in sufferers of rheumatoid arthritis and multiple sclerosis.