固始汗
In 1641 the leader of the Khoshut Mongols of the Kokonor region, Güshi Khan, set out from his home area and attacked the king of Beri in Kham, who was a practitioner of the Bon religion and persecuted Buddhist lamas. Güshi Khan had been in contact with "the Great Fifth" since 1637 and was a major champion for his cause. After having defeated Beri, he proceeded to invade Tsang. Justification for this was found in the alliance between Beri and Tsang, which allegedly aimed at eradicating the Gelugpa. The Dalai Lama was opposed to a Mongol invasion which would have devastating effects on Central Tibet, but was not able to change the course of events. Güshi Khan's reputation as an invincible commander rendered resistance weak. The Tsangpa stronghold, Shigatse, was captured after a long and bloody siege in March 1642. Karma Tenkyong was taken prisoner with his foremost ministers and kept in custody in Neu near Lhasa. After a revolt by Tsangpa supporters in the same year, the incensed Güshi Khan ordered Karma Tenkyong placed in an oxhide bag and drowned in a river. Güshi Khan, who founded the Khoshut Khanate, presented Ü, Tsang and part of East Tibet to the Dalai Lama to rule. In this way began the religious Ganden Phodrang regime that would last until 1950.