Mouvement Réformateur
In 1999, André-Léonard joined the federal government as the "commissaire du gouvernement à la simplification administrative", or government commissioner for administrative simplification. From 2000 to 2006, she was a member of the provincial government of Walloon Brabant, and in 2003 she was elected a Member of the European Parliament for a third time, as a member of the Liberal Reformist Party and the Mouvement Réformateur. Her final European Parliament term ended the very next year, on 19 July 2004.