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In 540 and 544 Dara was attacked by Khosrau I, who was unable to take it either time. Khosrau finally captured it in 573; its fall was said to have caused Justin II to go insane. Justin's wife Sophia and his friend Tiberius Constantine took control of the empire until Justin died in 578. Meanwhile, the Persians were able to march further into the empire, but Khosrau died in 579.