Antiochus I Soter
Apama II was a daughter of the second Seleucid king Antiochus I Soter, who was of Greek Macedonian and Persian descent, and Stratonice, a queen of Greek Macedonian descent. Her siblings included Stratonice of Macedon and the Seleucid King Antiochus II Theos. Her paternal grandparents were the first Seleucid King Seleucus I Nicator and his wife Queen Apama I, and her maternal grandparents were Antigonid King Demetrius I of Macedon and his wife Queen Phila. Apama was the namesake of her paternal grandmother and paternal aunt. Apama was born and raised in the Seleucid Empire.