Boston River
On February 5, 2014 Vancouver Whitecaps FC of Major League Soccer announced that they had signed Mezquida along with fellow Uruguayan Sebastián Fernández on a transfer from Boston River of the Uruguayan Segunda División where he had been playing since leaving Fenix. Mezquida went on to play five seasons for Vancouver, making 103 regular and postseason appearances, scoring 14 goals and adding four assists.