Cell adhesion
Physical immobilization is simply coating a material with a biomimetic material without changing the structure of either. Various biomimetic materials with cell adhesive proteins (such as collagen or laminin) have been used in vitro to direct new tissue formation and cell growth. Cell adhesion and proliferation occurs much better on protein-coated surfaces. However, since the proteins are generally isolated, it is more likely to elicit an immune response. Generally, chemistry qualities should be taken into consideration.