Seleucid Empire
The two largest Hellenistic kingdoms in the 3rd century BC, Ptolemaic Egypt and the Seleucid Empire, repeatedly fought for control of Syria in a series of conflicts known as the Syrian Wars. The Fourth Syrian War began in 219 BC, during which time Ptolemaic Egypt was ruled by Ptolemy IV, and the Seleucid Empire was ruled by Antiochus III the Great.