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For the Apertura 2018 season, Tigres rehired Guido Pizarro and on 15 July 2018, defeated Santos by 4–0 at the StubHub Center in Carson, California, becoming Champion of the Campeón de Campeones Cup for the third time in a row. On 19 September 2018, Tigres beat Toronto FC by 3–1 in the inaugural edition of the Campeones Cup hosted by Toronto at the BMO Field.