Spacing Guild
A small group of worlds, united as the League of Nobles, resist the initial Titan rebellion and remain free from machine rule. With the thinking machines ever-persistent in their intent to enslave or destroy all humans, the League initiates the Butlerian Jihad, mankind's century-long crusade against the machines. The humans are ultimately victorious, destroying all but one hidden copy of Omnius as well as the Titans, the neo-cymeks and all thinking machine forces. With all thinking machine technology henceforth banned, new organizations arise, composed of humans who had developed specialized skills during the Jihad to replace and exceed technology, including the Spacing Guild, Mentats, and the Bene Gesserit.