Francis, Duke of Guise
In 1546, she left court to take care of her ailing father and, after his death, she took care of the education of her brothers and sisters. Olympia's father died a convert to Protestantism, and Olympia embraced the doctrines of Luther and Calvin. When she returned to court, Anna d'Este's marriage to Francis, Duke of Guise left Olympia isolated. She spent her time studying philosophy and corresponded with Gasparo Sardi, who dedicated his "De Triplici Philosophia" to her.