Marguerite de Navarre
She was frail from birth, and grew up in the warm and temperate Loire Valley region of France, rather than at Paris, as her father feared that the cold would destroy her delicate health. Together with her sister Margaret, she was raised by her aunt, Marguerite de Navarre. This lasted until her father remarried and his new wife, Eleanor of Austria, took them into her own household. By her sixteenth birthday, she had contracted tuberculosis.