Bene Gesserit
Millennia later in "Dune", the Bene Gesserit base of power is the Mother School on the planet Wallach IX, whose graduates are fit mates for Emperors, and whose specially trained Truthsayers can detect falsehood. But beyond the outer virtues of poise, self-control, and diplomacy, Bene Gesserit training includes superior combat skills and precise physiological control that grants them direct control over conception and embryotic sex determination, ageing, and even the ability to render poisons harmless within their bodies. The Bene Gesserit power of Voice allows them to control others by merely modulating their vocal tones. Sisters who survive a ritualized poisoning known as the spice agony achieve increased awareness and abilities through access to Other Memory, and are subsequently known as Reverend Mothers. Every member of the Bene Gesserit is conditioned into singular loyalty to the order and its goals with allegiances to even family being secondary, and no goal is more paramount than the Sisterhood's large-scale breeding program. It aims to create a superbeing that can tap into abilities even the Bene Gesserit cannot, a being whom they can use in order to gain more direct control over the universe. To this end, the Bene Gesserit have subtly manipulated bloodlines for generations, using breeding sisters to "collect" the genes they require.