Interleague play
Entering the following year's spring training, he again had to compete to be the starter at first base. This time, it was with fellow prospect Logan Morrison. Sánchez earned the job on March 29, 2010 after Morrison was reassigned to the minors. On April 10, 2010, Sánchez hit his first home run of the 2010 season. He had his most successful game so far on June 11 in Interleague play against the Tampa Bay Rays, when he had four hits with two home runs and six RBIs.