Andronikos II Palaiologos
Irene was a daughter of "despotēs" Demetrios Palaiologos and his wife Theodora. Her paternal grandparents were Andronikos II Palaiologos and his second wife Irene of Montferrat. The paternal uncles of Irene included Michael IX Palaiologos and Theodore I, Marquess of Montferrat. Her maternal aunts included Simonida.