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Throughout the 190s, Cao Ren followed Cao Cao on various campaigns against rival warlords in central China. He made great contributions in the campaign against Yuan Shu between 197 and 199. When Cao Cao invaded Xu Province from 193–194 to attack the provincial governor Tao Qian, Cao Ren was in charge of the cavalry and he led the vanguard. He defeated Tao Qian's general Lü You (呂由) and led his force to rendezvous with Cao Cao's main army at Pengcheng (彭城; present-day Xuzhou, Jiangsu), where they scored a major victory over Tao Qian's forces. Cao Ren and his cavalry later defeated Tao Qian's subordinates in various battles at the counties in Xu Province. During the conflict between Cao Cao and Lü Bu, Cao Ren attacked Lü Bu's subordinate Liu He (劉何) at Gouyang (勾陽) and captured the enemy commander alive.