Schizosaccharomyces pombe
The metabolic pathway to produce ergothioneine starts with the methylation of histidine to produce histidine betaine (hercynine). The sulfur atom is then incorporated from cysteine. The biosynthetic genes of ergothioneine have been described in "Mycobacterium smegmatis", "Neurospora crassa", and "Schizosaccharomyces pombe".