ملعب فيسنتي كالديرون
Manquillo's debut in La Liga came on 9 December 2012, coming on for Filipe Luís late into the second half of a 6–0 home rout of Deportivo de La Coruña. On 3 September of the following year he signed a contract extension, keeping him at the Vicente Calderón Stadium until 2018.