Tibetan antelope
The Tibetan mastiff was able to adapt to the extreme highland conditions of the Tibetan Plateau very quickly compared to other mammals such as the yak, Tibetan antelope, snow leopard, and the wild boar. The Tibetan mastiff's ability to avoid hypoxia in high altitudes, due to its higher hemoglobin levels compared to low-altitude dogs, was due to prehistoric interbreeding. In 2020, a genomic analysis indicates that a ghost population of an unknown wolf-like canid which is deeply-diverged from modern Holarctic wolves and dogs has contributed the EPAS1 allele found in both Himalayan wolves and dogs, and this allows them to live in high altitudes.