Duchy of Mantua
In 1702, during the War of the Spanish Succession, the Duchy of Mantua was attacked by Imperiali who wished to conquer the areas of Luzzara and Cocoon. Ferdinando fled and left Anna Isabella to handle the situation as regent. During her second regency, she was assisted by Mr de Liesse. She appointed the commanders to handledto defense of Luzzara and Cocoon and issued negotiations for foreign protection of Sabbioneta.