Карони
In 1576 "Saint Thomas of Guyana" was first located in present-day Ciudad Guayana by missionaries near the Caroní River until Dutch forces led by Captain Adrian Janson destroyed the town in 1579. The second settlement was founded by Don Antonio de Berrío in 1595, who had arrived from the New Granada with the mission of colonizing Guiana, and was moved westward down the Carońi about . One of Walter Raleigh's expeditions sacked the second settlement in 1617, resulting in the death of his son Watt Raleigh.