Маморе
The area is part of the Mamoré River drainage, portion of the Amazon Basin. The Sécure River is one of the principal tributaries of the Mamoré and the Isiboro River itself flows into the Sécure. Both the Sécure and Isiboro flow through TIPNIS, and are located in the north and south of the park, respectively. The Ichoa River, a tributary of the Isiboro, flows through the central part of the park and receives water from various smaller streams. The Sécure and Isiboro drainages correspond the Yungas Mountainous Humid Forest and Madeira Humid Forest bioregions.