Craig Kimbrel
On February 26, 2021, Tepera re-signed with the Cubs on a one-year, $800K contract. On April 15, Tepera received a three-game suspension for intentionally throwing a pitch at pitcher Brandon Woodruff in a game against the Milwaukee Brewers. Tepera was named the NL Reliever of the Month for May. On June 24, 2021, Tepera pitched a combined no-hitter against the Los Angeles Dodgers along with Zach Davies, Andrew Chafin, and Craig Kimbrel.