Sleep deprivation
Down-regulation of dendrin is due to sleep deprivation which reduces the numbers of dendrin in the neuron. Sleep deprivation causes the most notable regulation and while it does not cause a decrease in dendrin mRNA and protein everywhere in the brain, the most significant change in dendrin levels is an overall decrease. Dendrin is regulated in the kidneys by CD2AP, which assists in dendrin movement to the nucleus of the podocyte. This movement mainly occurs when an injury, or cell death occurs in the podocyte epithelial cells.