薩長同盟
Yukitsugu’s son Tsuguakira became the last "daimyō" of Tsugaru Domain during the turbulent Bakumatsu period, during which time the Tsugaru clan first sided with the pro-imperial forces of Satchō Alliance, and attacked nearby Shōnai Domain. However, the Tsugaru soon switched course, and briefly joined the Ōuetsu Reppan Dōmei. However, for reasons yet unclear, the Tsugaru backed out of the alliance and re-joined the imperial cause after a few months, participating in several battles in the Imperial cause during the Boshin War, notably that of the Battle of Noheji, and Battle of Hakodate.