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His works included the church of the "Incarnation, of S. Domingos" and the Bemposta Chapel. In his capacity as Royal architect he worked on various of the many royal palaces, most notably being responsible for the great library at Palace of Mafra and the east wing of the Palace of Queluz, which is today that part of the palace reserved for a visiting head of state. He also designed the tower of the Royal Chapel. In 1795, to honour of the birth of Dom António, 4th Prince of Beira, de Sousa designed an amphitheatre for use as a bull ring constructed in the Praça do Comércio in Lisbon.