Marcion of Sinope
Jewish Christianity fell into decline during the Jewish–Roman wars (66–135) and the growing anti-Judaism perhaps best personified by Marcion of Sinope (c. 150). With persecution by the Nicene Christians from the time of the Roman Emperor Constantine in the 4th century, Jewish Christians sought refuge outside the boundaries of the Empire, in Arabia and further afield. Within the Empire and later elsewhere it was dominated by the gentile-based Christianity which became the State church of the Roman Empire and which took control of sites in the Holy Land such as the Church of the Holy Sepulchre and the Cenacle and appointed subsequent Bishops of Jerusalem.