Pescennius Niger
In 192, the Misenum fleet supported Didius Julianus, and then participated in the campaign of Septimius Severus against Pescennius Niger, transporting his legions to the East. The fleet remained active in the East for the next few decades, where the emergence of the Persian Sassanid Empire posed a new threat. In 258–260, the was employed in the suppression of a rebellion in North Africa.