Antiochus I Soter
From Lysimachus it passed to Seleucus I Nicator, whose son Antiochus I Soter, seeing its geographical importance, refounded it on a more open site as Apamea; Ronald Syme writes: "From a topographical point of view the change was less considerable than, for example, at Nysa, a new city constituted by the synoecism of three separate villages."