Aroldis Chapman
On December 28, 2015, the Yankees traded Cotham, Eric Jagielo, Rookie Davis, and Tony Renda to the Cincinnati Reds, in exchange for Aroldis Chapman. He made the Reds' Opening Day roster in 2016. He underwent season-ending knee surgery in August, finishing the 2016 season with an 0–3 win-loss record and a 7.40 ERA. The Reds outrighted Cotham from their 40-man roster after the season. He opted to become a free agent.