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Irene Laskarina (died 1240) (, "Eirēnē Laskarina") was an Empress of Nicaea. She was a daughter of Theodore I Laskaris, emperor of Nicaea and Anna Angelina. Her maternal grandparents were Emperor Alexios III Angelos and Euphrosyne Doukaina Kamaterina. Her sister Maria Laskarina married King Béla IV of Hungary.