Battle of Ipsus
In the Wars of the Diadochi, Coele-Syria came under the control of Antigonus I Monophthalmus. Then in 301 BCE, Ptolemy I Soter exploited events surrounding the Battle of Ipsus to take control of the region. The victors at Ipsus finalized the breakup of Alexander's empire. Coele-Syria was allocated to Ptolemy's former ally Seleucus I Nicator, who—having been previously aided by Ptolemy—took no military action to gain control of the region. Their successors, however, became embroiled in a series of conflicts over this issue.