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Pedrini was born in Fermo, in the Marche, then part of the Papal States. He was the founder of the Church of Our Lady of Mount Carmel, Beijing. He was the music teacher to three sons of the Qing Dynasty's Kangxi Emperor, he was co-author of the first treatise on Western Music theory ever written in Chinese: the "LǜlǚZhèngyì-Xùbiān", later included in the "Siku Quanshu".