Andronikos I Komnenos
Isaac II's first wife's name, Herina (i.e., Irene), is found on the necrology of Speyer Cathedral, where their daughter Irene is interred. Isaac's wife was possibly the daughter of Andronikos I Komnenos, Byzantine Emperor (died 1185). A potential foreign origin is also given to her due to having the same name as her daughter, contrary to long-standing Greek custom. Their third child was born in 1182 or 1183 and she was dead or divorced by 1185, when Isaac remarried. Their children were: