Akkadian Empire
Anatolia had remained in the prehistoric period until it entered the sphere of influence of the Akkadian Empire in the 24th century BC under Sargon of Akkad, particularly in eastern Anatolia. However, the Akkadian Empire suffered problematic climate changes in Mesopotamia, as well as a reduction in available manpower that affected trade. This led to its fall around 2150 BC at the hands of the Gutians.