詹姆斯·韦伯
Mueller became increasingly involved with NASA and the Apollo Program. NASA's Administrator James E. Webb sounded Mueller out for a top job. Mueller would only agree if the agency was restructured, and so during the fall of 1963 Webb worked with Associate Administrator Robert Seamans to restructure NASA, shifting three key centers (Manned Spacecraft Center (MSC), Marshall Space Flight Center (MSFC), and the Launch Operations Center (LOC)) to report directly to Mueller, as well as a local staff at Headquarters. Mueller accepted the job, and took a substantial pay cut. The reorganization of NASA and the Office of Manned Space Flight (OMSF) was announced in November 1963.