Tokugawa Iesada
Ieyoshi's official wife was Princess Takako (1795–1840), the sixth daughter of Prince Arisugawa Orihito. She relocated to Edo Castle in 1804 when she was only age 10, and they were formally wed in 1810. In 1813, she gave birth to a son, Takechiyo, followed by a daughter in 1815 and in 1816. In addition, Ieyoshi had another 13 sons and 11 daughters by numerous concubines; however, only one son, Tokugawa Iesada, lived past the age of 20.