Gwen Stacy
Issues 121–122 (June–July 1973, by Conway-Kane-Romita), which featured the death of Gwen Stacy at the hands of the Green Goblin in "The Night Gwen Stacy Died" in issue No. 121. Her demise and the Goblin's apparent death one issue later formed a story arc widely considered as the most defining in the history of Spider-Man. The aftermath of the story deepened both the characterization of Mary Jane Watson and her relationship with Parker.