Numazu, Shizuoka
The highway's origin and eastern terminus lies at Nihonbashi in Tokyo's Chūō ward. At Nihonbashi it meets national routes 4, 6, 14, 15, 17, and 20. The highway passes through the cities of Kawasaki, Yokohama, Odawara, Numazu, Shizuoka, Hamamatsu, Nagoya, Yokkaichi, Ōtsu, and Kyoto. Its endpoint and western terminus lies in the Umeda district of Osaka's Kita ward. In Umeda, it has a junction with national routes 2, 26, 163, 165, 25, and 176.