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Sofia Charlotta Wilkens née "Thomée" (December 14, 1817 – March 22, 1889) was a Swedish pedagogue. She is counted as a pioneer in the education of students with Intellectual disability, as well as deaf and mute students. She founded the Deaf and Mute Institute in Karlskrona, a combined orphanage, training school and working home for pupils with physical and intellectual disabilities, and was its manager from 1859-1877.