House of Lara
The Manrique line of the House of Lara, also known as the House of Manrique de Lara constituted one of the most powerful noble families in Medieval Spain, holding amongst their titles the Dukedom of Nájera and the Marquesado de Aguilar de Campoo. In 1520, when Charles I of Spain first recognized the original 25 Grandes de Espana, their house was amply represented amongst the list.