Seleucus II Callinicus
The marriage occurred early in the reign of Seleucus II Callinicus, so he could secure Anatolia behind him, so that Seleucus II could turn his attention to war with the Egyptian Greek Pharaoh Ptolemy III Euergetes. At some point, Laodice may have influenced Mithridates II by her desire to weaken the Seleucid state, by supporting her first brother Seleucus II Callinicus in joint rule with her other brother Antiochus Hierax, who were at civil war with each other. Laodice bore Mithridates II three children, two daughters: Laodice III, Laodice of Pontus and a son Mithridates III of Pontus.