Programmed cell death
FAT domains with a similar 4-helix bundle structure are also found in other proteins that localize to paxillin-containing focal adhesions and are involved in cell adhesion and migration, including the FAK-related protein kinase PTK2B/FAK2/PYK2, and alpha-catenin, vinculin, Programmed cell death protein 10 (PDCD10)/Cerebral Cavernous Malformation protein 3 (CCM3) and GIT1/GIT2.