Federico da Montefeltro
During the mid-1470s, Di Giorgio came into the employ of Federico da Montefeltro, Duke of Urbino. He created multiple artistic works for the Duke, including the bronze relief "Deposition from the Cross" and served as an architect and engineer for the duke during the Pazzi conspiracy. In the fighting between Italian city-states which followed, Di Giorgio constructed a series of great fortifications for his patron. This source of employment for Di Giorgio continued after da Montefeltro's death with his son the new duke.