Floyd Mayweather, Jr.
Ponce de León retained his title against Eduardo Escobedo on December 8, 2007 via unanimous decision, as part of the undercard of the Floyd Mayweather, Jr.–Ricky Hatton fight. On June 7, 2008 Ponce de León was defeated by technical knockout in the first round by Juan Manuel López, losing his WBO Super Bantamweight title.