Leo I the Thracian
Bishop Damianus of Callinicum took part in the [[Council of Chalcedon]] in 451 and in 458 was a signatory of the letter that the bishops of the province wrote to Emperor [[Leo I the Thracian]] after the death of [[Proterius of Alexandria]]. In 518 Paulus was deposed for having joined the anti-Chalcedonian [[Severus of Antioch]]. Callinicum had a Bishop Ioannes in the mid-6th century. In the same century, a "[[Notitia Episcopatuum]]" lists the diocese as a [[suffragan]] of [[Edessa]], the capital and [[metropolitan see]] of Osrhoene.