徳川家茂
From December 1849, he struggled to gain acceptance of the new smallpox vaccination, eventually opening 186 vaccination centers from Edo to Kyushu, and obtaining official recognition of the method in 1858. In 1862, Ogata was appointed personal physician to "shōgun" Tokugawa Iemochi, who supported the introduction of western medicine and the establishment of a western medicine research institute in Edo. However, Ogata died a few months later in July 1863 of acute hemoptysis, caused by the tuberculosis he had suffered from for many years.