Sadako Yamamura
Following the events of "Loop", Reiko Sugiura is called to meet with Toru Amano, a scientist of the LOOP project. She is shown events in the project: the deaths of Mai Takano and Hiroshi Toyama, both connected by Sadako Yamamura. Amano reveals to Reiko about the LOOP project, a simulated but alive universe mirroring the real world, how it was frozen 20 years ago just when the project was consumed by Sadako and her ring virus/Metastatic Human Cancer Virus (MHCV), and how Kaoru Futami, a reincarnation of Ryuji Takayama and Reiko's lover, had found a cure to neutralize the virus. Amano says that Kaoru entered the LOOP to find the cure and therefore is dead in the real world. However, he made a promise to Amano and Prof. Eliot to allow him meet with Reiko face-to-face. Reiko dons virtual reality goggles and gloves and is thrust into the LOOP, where she meets Kaoru attempting to assure her that everything is alright.