Charles Emmanuel III of Sardinia
Her father Louis Victor of Savoy was the Prince of Carignano and head of the cadet branch of the House of Savoy which ruled over Sardinia. Her mother was a daughter of the Landgrave of Hesse-Rotenburg and was a sister of the late Queen Polyxena of Sardinia, wife of Charles Emmanuel III of Sardinia. As such, Charles Emmanuel's children were Leopoldina's first cousins including the future King Victor Amadeus III of Sardinia.