Lares, Puerto Rico
Padilla helped organize the uprising against Spanish Colonial rule known as "El Grito de Lares," which was the first major revolt against Spanish rule and call for independence in Puerto Rico. The short-lived revolt, planned by Ramón Emeterio Betances and Segundo Ruiz Belvis and carried out by various revolutionary cells in Puerto Rico, occurred on September 23, 1868, and began in the town of Lares, Puerto Rico.