كريم بنزيما
In the first Madrid Derby of the season, on 4 October at the Vicente Calderón, Karim Benzema gave Real Madrid the lead, only for Luciano Vietto to later equalize, salvaged a 1–1 draw for Atlético. On 16 October, Atlético was drawn in the round of 32 of the 2015–16 Copa del Rey against Reus.