豚鼠
Since 2014 Sean has worked on Ebola drug discovery publishing 19 articles. One of these was the first use of a machine learning model to identify compounds active against Ebola (here). [SE2] This identified three active compounds (tilorone, quinacrine and pyronaridine) in vitro which have been subsequently tested in vivo and found to be active in mouse (Articles 1,2,3) (Most recently pyronaridine was shown to have some in vivo activity against Ebola in a Guinea pig. These molecules have also shown activity against Marburg, and bind the Ebola glycoprotein.