Manuel II Palaiologos
On 19 January 1421, Sophia was married to John VIII Palaiologos. He was the eldest surviving son of Manuel II Palaiologos and Helena Dragaš. He was at the time co-ruler with his father. The marriage was recorded by both Doukas and George Sphrantzes in their respective chronicles. Sphrantzes records Hagia Sophia as its location.