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NGC 6251 is an active supergiant elliptical radio galaxy more than 340 million light-years away from Earth. It has a Seyfert 2 active galactic nucleus, and is one of the most extreme examples of a Seyfert galaxy. This galaxy may be associated with gamma-ray source 3EG J1621+8203, which has high-energy gamma-ray emission. It is also noted for its one-sided radio jet—one of the brightest known—discovered in 1977.