Wu Guang
According to "" (94 BC) by Sima Qian, during Chen Sheng Wu Guang uprising in 209 B.C., Chen Sheng asked the question "how can kings, noblemen, generals and ministers be genetically determined?" (王侯將相寧有種乎) to call for revolution. Though Chen was obviously negative to the question, the phrase has often been cited as an early quest to the nature versus nurture problem.