水野氏
Several families were rotated through Karatsu for the next century: two generations of the Ōkubo clan; three generations of the Ogyū-Matsudaira clan, four generations of the Doi clan, and four of the Mizuno clan, including the famous reformer Mizuno Tadakuni. The domain then passed into the hands of Ogasawara Nagamasa, whose family remained until Karatsu domain was abolished in 1871. During the Boshin War of the Meiji Restoration of 1868-69, Ogasawara Nagamichi, the de facto ruler of Karatsu, led a group of his retainers on the side of the Ōuetsu Reppan Dōmei; after the fall of this alliance he went to Ezo and fought under the forces of the Ezo Republic. At the same time, Karatsu's domain-based administration was forced to pledge military support to the Satchō Alliance of Emperor Meiji.