Derby della Madonnina
On 20 November 2016, in the Derby della Madonnina against cross-town rivals A.C. Milan, Medel played as centre-back for 37 minutes before replaced by Jeison Murillo due to a knee injury. Following the match, which ended in a 2–2 draw, it was confirmed that Medel had damaged his lateral meniscus and would be sidelined until January 2017.