Seleucus II Callinicus
Kos also became a center of production of unrefined silk, oars and amphorae. Kos economic development during the period can further be exemplified by the 3rd and 2nd century BC construction of a theater, a new market with multiple stoas, a temple to Apollo at Alisarna, construction and expansion of the Asclepeion, fortification works at Alisarna and multiple richly decorated houses. In 240 BC, Ziaelas of Bithynia, Seleucus II Callinicus and Ptolemy III Euergetes provided guarantees for the transformation of Kos Asclepeion into an asylum. This decision made Kos a more attractive destination for merchants and pilgrims.