Mandylion
It was probably destroyed during the Byzantine Iconoclasm, after which mentions of an existing image cease (however Heinrich Pfeiffer identifies it with the Veil of Veronica and Manoppello Image), and in later centuries its place was taken by the Image of Edessa, which apparently arrived in Constantinople in 944, and icons of the Theotokos such as the Hodegetria. The Image of Edessa was very probably later, but had what apparently seemed to the Byzantines an even more impressive provenance, as it was thought to have been an authentic non-miraculous portrait painted from life during the lifetime of Jesus.