ケシ
The production methods have not significantly changed since ancient times. Through selective breeding of the "Papaver somniferum" plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting "Papaver orientale" or "Papaver bracteatum".