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All PDE5 inhibitors are generally well tolerated. The occurrence of side effects, or adverse drug reactions (ADRs), with PDE5 inhibitors depends on the dose and type of agent. Headache is a very common ADR, occurring in &gt;10% of patients. Other common ADRs include: dizziness, flushing, dyspepsia, nasal congestion or rhinitis. Back pain and muscle aches are also more common in patients taking tadalafil.