Hunan Normal University
Later syntheses have included an "atom-economical" method starting from -mannitol, developed by Indian pharmaceutical company Dr. Reddy's and reported in 1999, and a route starting from ("S")-glyceraldehyde acetonide (prepared from ascorbic acid), developed by a team of researchers from Hunan Normal University in Changsha, Hunan, China. On 25 June 2008, during the 12th Annual Green Chemistry and Engineering Conference in New York, Pfizer reported the development of their "second-generation" synthesis of linezolid: a convergent, green synthesis starting from ("S")-epichlorohydrin, with higher yield and a 56% reduction in total waste.