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A native of New York, she first appeared in a commercial at the age of eleven months. Her full-time acting career began by playing Sarah Roberts on "One Life to Live" (1994–1997) and Lizzie Spaulding on "Guiding Light" (1996–2000). Panettiere went on to star in the Disney sports drama film "Remember the Titans" (2000), the comedy-drama film "Raising Helen" (2004), the sports comedy film "Racing Stripes" (2005), the figure skating drama film "Ice Princess" (2005), the comedy film "I Love You, Beth Cooper" (2009), the true crime drama film "" (2011), the slasher horror film "Scream 4" (2011), and the drama film "Custody" (2016). She also voiced the characters of Kairi and Xion in the video game series "Kingdom Hearts" (2002–2017) and Samantha "Sam" Giddings in the video game "Until Dawn" (2015).