House of Gonzaga
The town's castle was home to a cadet branch of the House of Gonzaga, headed by the Marquis of Castiglione. Saint Aloysius Gonzaga (1568–1591) was born there as heir to the marquisate, but became a Jesuit. He died tending plague victims in Rome and was buried there, but his head was later translated to the basilica in Castiglione which bears his name.