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Khon Kaen Wittayayon School (Thai: ) is a public school located in Khon Kaen Province, Thailand. It admits secondary students (mathayom 1–6, equivalent to grades 7–12). Founded in 1897 as a boys' school for Khon Kaen Province, it became the first coeducational school in Khon Kaen. The school's former names were "Khon Kaen (boys') School" and "That Wittayakhan Temple School". The school's first principal was Mr. Tub Chimma.