妙手仁心
In the Season 1 two-part finale "Showdown" it is revealed that Karai is Hamato Yoshi's biological daughter, Miwa, whom Shredder abducted after accidentally killing Tang Shen, to get back at him. In "The Wrath Of Tiger Claw", Yoshi shows Karai the same photo she carries of her mother Tang Shen, proving Oroku Saki has lied about being her father. In 'Vengeance Is Mine, Hamato Yoshi's daughter was mutated into a mutant snake, much to Hamato Yoshi's despair. In "The Invasion", Hamato Yoshi battles the Shredder, but loses and is left to drown until Karai saves him. In "Vision Quest" Hamato Yoshi's spirit (which was detached from the body) guides the turtles to face the spirits of the forest. In "Return To New York", April O'Neil, Casey Jones and the Turtles return to see that Hamato Yoshi lost his sanity (which April then heals). In "The Deadly Venom", Karai is brainwashed by Shredder's brain-worm as Hamato Yoshi teaches Leonardo "The Healing Hands." In "The Fourfold Trap" Hamato Yoshi uses "The Healing Hands" to get rid of the worm that was possessing Karai. Unfortunately, much to Hamato Yoshi's despair, Karai fell and was flushed away into the sewers. Hamato Yoshi's healing hands worked because Karai was able to free herself from the brain washing worm.