Francis, Duke of Guise
According to French law, Francis was an adult who did not need a regent but since he was young, inexperienced, and in fragile health, he delegated his power to his wife's uncles from the noble House of Guise: Francis, Duke of Guise, and Charles, Cardinal of Lorraine. His mother, Catherine de' Medici, agreed to this delegation. On the first day of his reign, Francis II instructed his four ministers to take orders from his mother, but since she was still in mourning for her husband, she directed them to the House of Guise.