Doctor Octopus
The game's story follows Spider-Man as he attempts to clear his name after being framed by a doppelgänger and becoming a wanted criminal, while also having to foil a symbiote invasion orchestrated by Doctor Octopus and Carnage. Numerous villains from the comics appear as bosses, including Scorpion, Rhino, Venom, Mysterio, Carnage, and Doctor Octopus, as well as a Carnage symbiote-possessed Doctor Octopus named Monster-Ock, who was created exclusively for the game as the final boss.