Sleep deprivation
Sleep deprivation also has a documented effect on the ability to acquire new memories for subsequent consolidation. A study done on mice that were sleep deprived before learning a new skill but allowed to rest afterward displayed a similar number of errors on later trials as the mice that were sleep deprived only after the initial learning. In this case, it is hypothesized that rather than preventing the memory from being consolidated, sleep deprivation interfered with the initial acquisition of the memory. Mice with pre-trial sleep deprivation also took significantly longer to learn a task than well-rested mice.