Akinori Iwamura
Tampa Bay scored the first runs of the game in the first inning when Akinori Iwamura and B. J. Upton scored on consecutive ground outs by Carlos Peña and Evan Longoria respectively. The following inning Upton singled, scoring Dioner Navarro. Rocco Baldelli attempted to score from second base, but was thrown out by right fielder Jayson Werth, keeping the Rays lead at 3–0. Cliff Floyd extended the Rays lead to four runs after leading off the bottom of the fourth inning with a single, advancing to third base, and scoring on a Jason Bartlett sacrifice bunt. Rays starter James Shields shut out the Phillies through 5⅔ innings to earn the win, before being relieved by Dan Wheeler who pitched an additional scoreless inning. Philles starter Brett Myers lasted seven innings, giving up four runs (three earned) and took the loss. Eric Bruntlett hit a home run in the top of the eighth inning to bring the score to 4–1. The Phillies added a second run in the top of the ninth inning against David Price, but were unable to score any more runs; Tampa Bay's win tied the Series at one game apiece.