Gran Esposa Real
Although in these later instances Iset is referred to as Great Royal Wife, during the reign of Thutmose II the great royal wife was Hatshepsut. Thutmose II died in 1479 BC and, after his death, Hatshepsut became regent for the young king Thutmose III. Thutmose III became the head of the armies of Egypt as he grew up.