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The Coppermine River flood basalts were extruded shortly after a period of crustal uplift that later resulted in a short period of collapse in the associated landscape. This sudden uplift was likely caused by rising magma of the Mackenzie plume, which later resulted in the appearance of the Mackenzie hotspot. The early Muskox intrusion is considered to have originally been a sill-shaped magma reservoir for the overlying Coppermine River flood basalts during their formation. With the Coppermine River basalts comprising more than 100 individual lava flows, the potential volumes of silicate magma that moved through the Muskox conduit were in the order of .