Érik Morales
On 17 September 2011 Cano faced three-division titleholder Érik Morales for a vacant WBC super lightweight title, on the undercard of Victor Ortiz vs. Floyd Mayweather. Cano lost via technical knockout (TKO) in the tenth round to Erik Morales. He replaced hard-hitting Lucas Matthysse of Argentina, who withdrew with a viral infection that prevented him from training.