Thutmose I
Amenhotep I probably left no male heir and the next pharaoh, Thutmose I, seems to have been related to the royal family through marriage. During his reign the borders of Egypt's empire reached their greatest expanse, extending in the north to Carchemish on the Euphrates and in the south up to Kurgus beyond the fourth cataract of the Nile. Thutmose I was succeeded by Thutmose II and his queen, Hatshepsut, who was the daughter of Thutmose I. After her husband's death and a period of regency for her minor stepson (who would later become pharaoh as Thutmose III) Hatshepsut became pharaoh in her own right and ruled for over twenty years.