John Randolph of Roanoke
Virginia legislators elected the Jacksonian Democrat John Randolph of Roanoke to succeed Senator Barbour in December 1825. Like Barbour, he would defend slavery, although a member of the American Colonization Society like Henry Clay, and unlike Barbour, he would later manumit his own slaves upon his death. Randolph had opposed both the national bank and the Missouri Compromise of 1820 that Barbour had helped Clay pass.