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Dalmatians, like humans, can suffer from hyperuricemia. Dalmatians' browns have trouble breaking down uric acid, which can build up in the blood serum (hyperuricemia) causing gout. Uric acid can also be excreted in high concentration into the urine, causing kidney stones and bladder stones. These conditions are most likely to occur in middle-aged males. Males over 10 are prone to kidney stones and should have their calcium intake reduced or be given preventive medication. To reduce the risk of gout and stones, owners should carefully limit the intake of purines by avoiding giving their dogs food containing organ meats, animal byproducts, or other high-purine ingredients. Hyperuricemia in Dalmatians responds to treatment with orgotein, the veterinary formulation of the antioxidant enzyme superoxide dismutase.