Francesco I Sforza
The city was ruled by the Malcavalca until 1211, when they were succeeded the Ottoni di Matelica. Three years later, and for three hundred years, the da Varano family hold the city. Under the da Varano Santa Anatolia maintained a certain autonomy: the first collection of statutory norms dates from 1324. The citadel remained immune from wars and pillages until 1443, when it was conquered by Francesco I Sforza. The monastery of Sant'Angelo and its library did not escape the devastation.