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Gas exchange rate was used as an indicator of chemical stress in Northern bobwhite quail ("Colinus virginianus") eggs, and no evidence of alterations in metabolic rates associated with HMX exposure was observed. No data are available concerning the possible reproductive, developmental, or carcinogenic effects of HMX. HMX is considered the least toxic amongst TNT and RDX. Remediating HMX contaminated water supplies has proven to be successful.