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Iulia Motoc became a member of the United Nations Subcommission on Human Rights in 1996, first as an alternate and in 2000–2001 she served as a President of United Nations Subcommission on Human Rights. She has co-authored the Working Paper on Free, Prior and Informed Consent of the Indigenous People which was incorporated in the UN Declaration for Indigenous People. Motoc was on the co-author of the UN Guidelines principles for Extreme poverty. She was the UN Special Rapporteur on Human Rights and the Human Genome, author of the first reports of the United Nations in the field of genetics (2004–2007).