Macedonian Wars
In the 3rd century BC Epirus remained a substantial power, unified under the auspices of the Epirote League as a federal state with its own parliament (or "synedrion"). However, it was faced with the growing threat of the expansionist Roman Republic, which fought a series of wars with Macedonia. The League remained neutral in the first two Macedonian Wars but split in the Third Macedonian War (171–168 BC), with the Molossians siding with the Macedonians and the Chaones and Thesproti siding with Rome. The outcome was disastrous for Epirus; Molossia fell to Rome in 167 BC, 150,000 of its inhabitants were enslaved and the region was so thoroughly plundered that it took 500 years for central Epirus to recover fully.