Muhammad Shaybani
In 1501 the Uzbeks conquered Transoxiana for good from the Abu Sa'id's grandson, Babur. Under Muhammad Shaybani, the Uzbeks could now threaten Khurasan. Suffering from the effects of advanced age, Husayn made no move against them, even after Babur advised him to act. The Uzbeks began conducting raids into his kingdom. Finally changing his mind, he began to march against them but died in 1506 just after beginning his advance. The inheritance of his empire was disputed between his sons Badi' and Muzaffar Husain. Babur, who had begun an expedition in support of Husayn, noted the infighting between the brothers, decided the area was impossible to defend and retreated. The next year, Muhammad Shaybani conquered Herat and caused Husayn's successors to flee, putting an end to Timurid rule in Khurasan.