Bene Gesserit
Paul is the Kwisatz Haderach, and eventually sets the Imperium on a course lasting thousands of years in the person of his son, Leto II. Much to the frustration of the Bene Gesserit, they do not control Paul, and the events of the coming millennia leave Jessica noteworthy as a figure of history who committed a great wrong (according to the Bene Gesserit); in the coming centuries, for a Bene Gesserit to choose her love over the instructions of her order is known as "the Jessica crime."