Uric acid
A uric acid deficiency was implicated in this process. Uric acid added in physiological concentrations (i.e. achieving normal concentrations) is therapeutic in MS by preventing BBB breakdown through inactivation of peroxynitrite. The low level of uric acid found in MS victims is manifestedly causative rather than a tissue damage consequence in the white matter lesions, but not in the grey matter lesions. Uric acid levels are lower during relapses.