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Pauling began studying vitamin C mega-dosage, and orthomolecular medicine more broadly, after he was contacted in 1966 by biochemist Irwin Stone, who suggested that taking enough vitamin C would let him live another fifty years. Pauling reinterpreted the large body of research on vitamin C based on comparative studies of the biochemical genetics of vitamin C synthesis in different species, as well his own theories about "molecular disease" and recent developments in molecular evolution. He criticized the design of studies that did not find positive results for vitamin C mega-dose treatment, and promoted those that did. He and other vitamin C advocates thought the vitamin boosts the body's ability to fight all kinds of infection. By 1970, after following Stone's regimen for four years and studying and debating the issue extensively, Pauling was sure enough that organized medicine had it wrong that he wrote "Vitamin C and the Common Cold" to popularize his vitamin C message.