African trypanosomiasis
"Trypanosoma brucei gambiense" accounts for the majority of African trypanosomiasis cases, with humans as the main reservoir needed for the transmission, while "Trypanosoma brucei rhodesiense" is mainly zoonotic, with the occasional human infection. African Trypanosomiasis is dependent on the interaction of the parasite (trypanosome) with the tsetse flies (vector), as well as the host (human for "Trypanosoma brucei gambiense", and animals for "Trypanosoma brucei rhodesiense"). The risk of contracting African Trypanosomiasis is dependent on coming in contact with an infected tsetse fly.