Accra Hearts of Oak SC
Opoku began his career with Corners Babies, and joined Accra Hearts of Oak SC in 2008. After a short stint there he signed with Asante Kotoko. He played his debut match for Asante Kotoko in the CAF Champions League against Étoile du Sahel. After three years with Asante Kotoko, joined to Ghana Premier League rival Ashanti Gold SC. He was voted the BEST PLAYER OF GHANA in the just ended Ghana Premier League 2015. He is a utility player who plays as a centre back and a defensive midfielder. He is nicknamed "Hello Kwaku"