Juan Manuel, Prince of Villena
During his minority, his upbringing and the custody of his person were entrusted to his mother, Queen María de Molina, while his tutorship was entrusted to his granduncle Henry of Castile the Senator. At that time, and also for the rest of his reign, his mother tried to placate the nobility, confronted her son's enemies, and repeatedly prevented Ferdinand IV from being dethroned. He faced the insubordination of the nobility, led at numerous times by his uncle John of Castile, Lord of Valencia de Campos, and by Juan Núñez II de Lara, who were supported in some occasions by another royal relative, Juan Manuel, Prince of Villena.