Wars of the Diadochi
Some empires, such as the Persian and Macedonian empires, did make deep inroads into Central Asia by founding cities and gaining control of the trading centres. Alexander the Great's conquests spread Hellenistic civilisation all the way to Alexandria Eschate (Lit. “Alexandria the Furthest”), established in 329 BC in modern Tajikistan. After Alexander's death in 323 BC, his Central Asian territory fell to the Seleucid Empire during the Wars of the Diadochi.