Wang Mang
In 3 CE, Wang Yu formed a conspiracy with his teacher Wu Zhang (吳章), his brother-in-law Lü Kuan (呂寬), and the Weis, to try to see what they can do to break Wang Mang's dictatorial hold. They decided that they would create what appear to be supernatural incidents to make Wang Mang concerned, and then have Wu try to persuade Wang Mang to transfer power to the Weis. Wang Yu told Lü to toss a bottle of blood onto Wang Mang's mansion door to create that effect—but Lü was discovered by Wang Mang's guards. Wang Mang then arrested Wang Yu, who then committed suicide, and his wife (Lü Kuan's sister) Lü Yan (呂焉) was executed. Wang Mang then executed the entire Wei clan, except for Consort Wei. Wu was cut in half and then drawn and quartered. (It is not known what happened to Lü, but it would appear that there would be no way for him to escape death.)