Piero di Cosimo
Simonetta Vespucci may also be depicted in the painting by Piero di Cosimo titled "Portrait of a woman, said to be of Simonetta Vespucci", which portrays a woman as Cleopatra, with an asp around her neck. Yet how closely this resembles Simonetta is uncertain, not least because it is a posthumous portrait created about 14 years after her death. (Worth noting as well is the fact that Piero di Cosimo was only 14 years old the year of Simonetta's death.) The museum that currently houses this painting, the Musée Condé, questions the identity of its alleged subject and titles it "Portrait of a woman, said to be of Simonetta Vespucci", noting that the inscription of her name at the bottom of the painting may have been added at a later date.