Thomas Lüthi
Lowes returned to Moto2 for the 2018 season, riding a KTM bike for the Swiss Innovative Investors team, partnering Iker Lecuona. He replaced Thomas Lüthi, who moved up to MotoGP with the EG 0,0 Marc VDS team. Lowes finished 16th in the riders' championship, scoring 49 points, and he failed to score a single fastest lap, podium, win, or pole position for the first time since he made his Moto2 début in 2014.