Tokugawa Iesato
The death of Shogun Iemochi put an end to their very short marriage, and the couple did not have any children. When Iemochi's will to have Tokugawa Iesato succeed him arrived in Edo, the "rōjū" consulted her and Tenshō-in, voicing opposition to having someone so young as "shōgun" during such turbulent times, Seikan'in and Tenshō-in instead supported Tokugawa Yoshinobu, who would become the last Tokugawa Shogun. However their relationship quickly turned sour as public opinion turned against Yoshinobu.