Mesa Solar Sox
Mayberry played only 11 games with the Phillies in 2010, batting .333 with two home runs, and spending the majority of the season (128 games) at Triple-A Lehigh Valley, with whom he hit .267 with 15 home runs and 65 RBIs. 2010 marked the first year during which Mayberry spent multiple stints in the major and minor leagues, which he described as "different". He did earn a September callup, and "made a case" to have a place on the Phillies' postseason roster, but was assigned to the Mesa Solar Sox of the Arizona Fall League (AFL) instead. He left the AFL after just one game, with a leg injury.