Liu E
Wu Ban participated in the Battle of Xiaoting of 221–222 against Shu's ally-turned-rival state, Eastern Wu. In the initial stages of the battle, the units led by Wu Ban and Feng Xi attacked and captured Wu positions at the Wu Gorge, which were guarded by the Wu officers Li Yi (李異) and Liu E (劉阿). As the Shu army advanced further, Liu Bei ordered Wu Ban and Chen Shi to lead the Shu navy to station at Yiling (夷陵; southeast of present-day Yichang, Hubei) in between the east and west banks of the Yangtze. After the Shu army passed through the Wu Gorge, Liu Bei instructed Wu Ban to lead a few thousand soldiers out of the mountainous terrain and set up camps on flat ground to provoke the Wu forces to attack them, but failed to lure the enemy out into a trap. The Shu forces ultimately lost the Battle of Xiaoting and retreated back to Shu.