岩窟の聖母
Cristoforo is part of the de Predis family of artists, where he was one of six brothers including Giovanni. He was born deaf and dumb, in the parish of San Vincenzo in Prato to parents Leonardo de Predis and Margaret Giussani. The de Predis family hosted Leonardo da Vinci when he visited Milan for the commission Virgin of the Rocks, and Leonardo met Cristoforo on that occasion. Leonardo later wrote about what can be learned from dumb people in his treatise on painting Codex Urbinas.