室女座星系團
Messier 49 was the first member of the Virgo Cluster of galaxies to be discovered. It is the most luminous member of that cluster and more luminous than any galaxy closer to the Earth. This galaxy forms part of the smaller Virgo B subcluster 4.5° away from the dynamic center of the Virgo Cluster, centered on Messier 87. Messier 49 is gravitationally interacting with the dwarf irregular galaxy UGC 7636. The dwarf shows a trail of debris spanning roughly 1 × 5 arcminutes, which corresponds to a physical dimension of .