Dopamine receptor
The mesocortical pathway ( mesocorticolimbic system, mesocorticolimbic pathway) refers to both the mesocortical and mesolimbic pathways. Both pathways originate at the ventral tegmental area (VTA). Through separate connections to the prefrontal cortex (mesocortical) and ventral striatum (mesolimbic), the mesocorticolimbic projection has a significant role in learning, motivation, reward, memory and movement. Dopamine receptor subtypes, D1 and D2 have been shown to have complementary functions in the mesocorticolimbic projection, facilitating learning in response to both positive and negative feedback. Both pathways of the mesocorticollimbic projection are associated with ADHD, schizophrenia and addiction.