Brontë family
In 1848 Brontë began work on the manuscript of her second novel, "Shirley". It was only partially completed when the Brontë family suffered the deaths of three of its members within eight months. In September 1848 Branwell died of chronic bronchitis and marasmus, exacerbated by heavy drinking, although Brontë believed that his death was due to tuberculosis. Branwell may have had a laudanum addiction. Emily became seriously ill shortly after his funeral and died of pulmonary tuberculosis in December 1848. Anne died of the same disease in May 1849. Brontë was unable to write at this time.