Fukuzawa Yukichi
In 1838, the physician and scholar Ogata Kōan established the Rangaku school named Tekijuku. Famous alumni of the Tekijuku include Fukuzawa Yukichi and Ōtori Keisuke, who would become key players in Japan's modernization. He was the author of 1849's , which was the first book on Western pathology to be published in Japan.