Cosimo I de' Medici, Grand Duke of Tuscany
During the 16th century, Fernando Álvarez de Toledo, 3rd Duke of Alba, was given the title of governor general of the Spanish Netherlands. The third duke's first cousin was Eleanor of Toledo, who married Cosimo I de' Medici, Grand Duke of Tuscany. Through her granddaughter Marie de' Medici, Queen of France, she became the ancestor of many crowned heads and heirs apparent of Europe.