Ptolemy V Epiphanes
Under Antiochus III, the Seleucids wrested control of Palestine from the Ptolemies for the final time, defeating Ptolemy V Epiphanes at the Battle of Panium in 200 BCE. Seleucid rule over the Jewish parts of the region then resulted in the rise of Hellenistic cultural and religious practices: "In addition to the turmoil of war, there arose in the Jewish nation pro-Seleucid and pro-Ptolemaic parties; and the schism exercised great influence upon the Judaism of the time. It was in Antioch that the Jews first made the acquaintance of Hellenism and of the more corrupt sides of Greek culture; and it was from Antioch that Judea henceforth was ruled."