Hematopoietic stem cell
Endothelial Injury Syndromes (EIS) - any disorder which causes damage to the endothelium puts patients at risk of thrombotic microangiopathy or TMA. endothelial damage triggers the lectin pathway of the Complement System. This initiation leads to coagulation and activation of the classical pathway of complement. EIS examples: atypical hemolytic uremic syndrome (aHUS), Hematopoietic stem cell transplantation (HSCT), Corona Virus Disease 2019 (COVID-19), Graft vs. Host Disease (GVHD) and many others. Additional resources on Endothelial Injury Syndrome