ミラノダービー
Later on 14 March 2019, in the second leg of Europa League round of 16, De Vrij's wrong ball control resulted fatal for Inter who conceded inside 5 minutes, and eventually lost the game to Eintracht Frankfurt 1–0 at San Siro, crashing out of competition 1–0 on aggregate. Three days later, De Vrij scored in the Derby della Madonnina match against rivals Milan, helping his team to win 3–2, taking back the third place in championship, and completing the first league double over them since 2011–12 season.