Ashina Helu
In 657, Emperor Gaozong commissioned the general Su Dingfang, who had served under Cheng Zhijie in the earlier failed campaign, to command a campaign against Ashina Helu, assisted by Ren Yaxiang and Xiao Siye (). They were joined by the Western Turkic Khaganate’s leaders Ashina Mishe and Ashina Buzhen, who had submitted to Tang during Emperor Taizong's reign. The campaign caught Ashina Helu by surprise, and Su defeated him in several battles, causing him to flee to the kingdom Shi (石國, centering modern Tashkent, Uzbekistan), which arrested him and delivered him to Su, thus largely ending the Western Turkic Khaganate as an organized state. (Emperor Gaozong would try to continue the Western Turkic Khaganate's existence as a vassal stage by dividing it in half and creating Ashina Mishe and Ashina Buzhen as khans of the two halves.)