معركة وادي المخازن
John III was succeeded in 1557 by his grandson Sebastian I of Portugal, who died, aged 24 and childless, in the Battle of Alcácer Quibir. Sebastian was succeeded by his great-uncle Henry, aged 66, who, as a Catholic Cardinal, also had no children. The Cardinal-King Henry died two years later, and a succession crisis occurred when pretenders to the throne including Catherine, Duchess of Braganza, Philip II of Spain, and António, Prior of Crato claimed the right to inherit it.