虎鯨
The most common natural predator of sperm whales is the killer whale, but pilot whales and false killer whales sometimes harass them. Killer whales prey on target groups of females with young, usually making an effort to extract and kill a calf. The females will protect their calves or an injured adult by encircling them. They may face inwards with their tails out (the 'marguerite formation', named after the flower). The heavy and powerful tail of an adult whale is potentially capable of delivering lethal blows. Alternatively, they may face outwards (the 'heads-out formation'). Other than sperm whales, southern right whales had been observed to perform similar formations. However, formations in non-dangerous situations have been recorded as well. Early whalers exploited this behaviour, attracting a whole unit by injuring one of its members. Such a tactic is described in "Moby-Dick": "Say you strike a Forty-barrel-bull—poor devil! all his comrades quit him. But strike a member of the harem school, and her companions swim around her with every token of concern, sometimes lingering so near her and so long, as themselves to fall a prey."If the killer whale pod is large, its members may sometimes be able to kill adult female sperm whales and can at least injure an entire pod of sperm whales. Bulls have no predators, and are believed to be too large, powerful and aggressive to be threatened by killer whales. Solitary bulls are known to interfere and come to the aid of vulnerable groups nearby. However, the bull sperm whale, when accompanying pods of female sperm whales and their calves as such, may be reportedly unable to effectively dissuade killer whales from their attacks on the group, although the killer whales may end the attack sooner when a bull is present. However, male sperm whales have been observed to attack and intimidate killer whale pods in competitive feeding instances. An incident was filmed from a long-line trawler: a killer whale pod was systematically taking fish caught on the trawler's long lines (as the lines were being pulled into the ship) when a male sperm whale appeared to repeatedly charge the killer whale pod in an attempt to drive them away; it was speculated by the film crew that the sperm whale was attempting to access the same fish. The killer whales employed a tail outward and tail-slapping defensive position against the bull sperm whale similar to that used by female sperm whales against attacking killer whales. However, at some potential feeding sites, the killer whales may prevail over sperm whales even when outnumbered by the sperm whales. Some authors consider the killer whales "usually" behaviorally dominant over sperm whales but express that the two species are "fairly evenly matched", with the killer whales' greater aggression, more considerable biting force for their size and predatory prowess more than compensating for their smaller size.