Coho salmon
Little Butte Creek is known to be one of the best salmon producing tributaries of the Rogue River, and is also one of only a few streams in the Upper Rogue watershed to support salmon populations. The most common anadromous fish inhabiting the creek include chinook and coho salmon, and sea-run cutthroat trout. The Southern Oregon/Northern California Coast Coho Salmon Evolutionary Significant Unit is listed as threatened (2011). Coho salmon are known to spawn in of streams in the Little Butte Creek watershed. An estimated 35,131 Coho salmon lived in the creek in 2002. Resident fish include coastal cutthroat trout, sculpins, rainbow trout, and brook trout.