DNAメチル化
CpG DNA methylation has showed a role to regulate the alternative splicing in social insects. In honey bees ("Apis mellifera"), CpG DNA methylation seems to regulate the exon skipping based on the first few genomic studies after honey bee genome was available. CpG DNA methylation regulated alternative splicing more extensively, not only affect exon skipping, but also intron retention, and other splicing events.