Ponce de León
Juan Ponce de León y Loayza's father, Juan Ponce de León II, was the son of lady Juana Ponce de León, one of three daughters born of Juan Ponce de León, the Spanish conquistador, and his wife Leonora Ponce de León (their other three children were Isabel, Maria, and Luis). Thus, Juan Ponce de León y Loayza was the great-grandson of the Spanish conquistador and first governor of Puerto Rico, Juan Ponce de León.