Giuliano de' Medici
Clement VII, also known as Giulio di Giuliano de' Medici, was the nephew of Lorenzo and the son of Giuliano de' Medici, who was assassinated in the Pazzi conspiracy in 1478. As with Leo X, Michelangelo was educated alongside Clement VII and for many years, the two communicated in great detail both via letter and in person. Despite that Clement VII was an illegitimate child, he became an archbishop via papal dispensation, in which Leo X stipulated that his parents had been secretly married. Thus, Giulio de' Medici was made cardinal in 1513 and in 1523 became pope. Numerous misfortunes occurred during his papacy, including the Sack of Rome, the English Reformation, and Martin Luther's ongoing Protestant Reformation.