Dou Xian
During the first part of Emperor He's reign, the clan of Empress Dowager Dou, particularly her brother Dou Xian, dominated the political scene. That trend continued even as Emperor He grew older and older. Dissatisfied with the autocratic authorities of Dou Xian, Emperor He pondered his options. Apparently encouraged by Prince Qing and the eunuch Zheng Zhong, Emperor He carried out a coup d'état in 92 and toppled the Dous' power. (Prince Qing's involvement in the plot is not completely clear but apparently major, and it is speculated that his motivation was to avenge himself (for being deposed) and his mother (for being forced to commit suicide).)