Emperor Go-Mizunoo
Lady Saigō was the ancestral mother to the line of "shōguns" that began with the second Edo-period "shōgun", Tokugawa Hidetada, and ended with the seventh, Tokugawa Ietsugu (1709–1716). Aside from this, Lady Saigō also became connected to the Imperial line. In 1620, Hidetada's daughter, Tokugawa Masako (1607–1678), married Emperor Go-Mizunoo and entered the Imperial palace. As empress consort, Masako helped maintain the Imperial Court, supported the arts, and significantly influenced the next three monarchs: the first was her daughter, and the two that followed, Emperors Go-Kōmyō and Go-Sai, were sons of Emperor Go-Mizunoo by different concubines. The daughter of Masako, and thus great-granddaughter of Lady Saigō, was Princess Okiko (1624–1696), who acceded to the Chrysanthemum Throne in 1629 as Empress Meishō. She reigned for fifteen years as the 109th monarch of Japan, the seventh of only eight empresses regnant in the history of Japan, until she abdicated in 1643.