The Gold-Bug
The novel intertwines the discovery of the chemical structure of DNA with the musicality of Johann Sebastian Bach's harpsichord composition the Goldberg Variations. A similar theme is explored by Douglas Hofstadter in his 1979 book "Gödel, Escher, Bach: an Eternal Golden Braid. "The title also alludes to Edgar Allan Poe's 1843 short story "The Gold-Bug", which is also incorporated in the plot of the novel.