Борджиа
Pope Callixtus III, the first pope of the House of Borgia, died on August 6, 1458. He was severely criticized due to his nepotism and devotion towards his compatriots of Catalonia, making him very unpopular among the rather xenophobic Roman populace. After the Pope's death an open revolt against him broke out and some of his partisans (e.g. his nephew Pedro Luis de Borja) had to flee Rome.