Francis, Duke of Guise
Antoinette and her family have been described as "ultra-Catholic"; in 1533 Antoinette oversaw the burning of a Protestant man caught preaching in the town of Wassy. Her son Francis, Duke of Guise was held to be responsible for the anti-Protestant Massacre of Wassy on 1 March 1562 which was one of the early atrocities in the French Wars of Religion.