He Yan
The "Book of Jin" says that Huangfu Mi used "hanshisan" poisoning as an excuse to decline a position offered by Emperor Wu (r. 265–290). The Cold Food Powder "disagreed with his nature and each time he was convulsed with excruciating pain. Once in a rage of suffering he prayed for a sword with which to kill himself, but his aunt remonstrated with him and made him stop." Huangfu said that the vogue for consuming Cold-Food Powder began with the Cao Wei state (220–265) scholar and politician He Yan (c. 195–249), who used the drug to achieve greater spiritual clarity and physical strength. He Yan and his friend Wang Bi (226–249), co-founders of the Daoist Xuanxue School, propagated the consumption of the drug in their philosophical circles. The French sinologist Paul Demiéville's described He Yan: "He was reckoned a paragon of beauty, elegance, and refinement, a floating flower ("fou-hua") as his enemies used to say, or a dandy. He "loved Lao-Huang" and shone in "pure conversation." His lack of constraint brought down on him the ill-will of the orthodox traditionalists. He is even said to have brought into fashion a drug that brought on a state of ecstasy, and many of his friends and epigones were drug addicts."