San Antonio Missions
Spangenberg signed a one-year deal with the Milwaukee Brewers on January 4, 2019. He opened the 2019 season with the San Antonio Missions. On May 14, he was designated for assignment. On August 24, the Brewers selected Spangenberg's contract. In AAA with the San Antonio Missions, he led the PCL with 28 stolen bases while being caught four times, and batted .309/.378/.498.