Methylene blue
Methylene blue has been found to be useful for this condition. Although use of methylene blue has mostly been in adults it has also been shown to work in children. Its mechanism of action is thought to be via the inhibition of the nitric oxide-cyclic guanosine monophosphate pathway. This pathway is excessively activated in septic shock. Methylene blue has been found to work in cases resistant to the usual agents. This effect was first reported in the early 1990s.