横浜市立大学
In 1991, Ohno became Professor and Chair of the Department of Molecular Biology at Yokohama City University School of Medicine, and led several medical students and junior researchers, as well as actively advanced collaborative researches with physician scientists. His lab focused on cell signaling via PKC and the molecular mechanisms how cell polarity is related to other signaling pathways such as cell growth, apoptosis and carcinogenesis. Another project is the mechanism of the quality control of mRNA, a mechanism called nonsense-mediated mRNA decay.