井伊直政
Ii Naomasa was transferred to Hikone Domain, and Takasaki given to Sakai Ietsugu in 1604 with its revenues reduced to 50,000 "koku". The domain then passed through two branches of the Matsudaira clan before it was awarded to Ando Shigenobu in 1619. The Andō clan ruled over three generations to 1695. Matsudaira Terusada of the Ōkōchi branch of the Matsudaira clan became daimyō in 1695. He also served in a number of important offices under Shōgun Tokugawa Tsunayoshi and Tokugawa Ienobu, and the domain was raised to 75,000 "koku". He was replaced at Takasaki by Manabe Akifusa, another favorite of Tokugawa Ienobu in 1710, but returned to Takasaki in 1716, and his descendants continued to rule Takasaki until the end of the Edo period.