Grand Unified Theory
Abraham Pais wrote about Chern in his book "Subtle is the Lord." To paraphrase one passage: the outstanding mathematician Chern has two things to say, 1) I feel very mysterious that in the fields I'm working on (general relativity and differential geometry) there is so much more that can be explored; and 2) when talking with Albert Einstein (his colleague at the IAS) about his problem of a Grand Unified Theory, I realized the difference between mathematics and physics is at the heart of the journey towards a theory of everything.