ホメオティック遺伝子
The "mir-10" genes are found within the Hox gene clusters. In mammals there are four Hox gene clusters, these contain five genes encoding miRNAs ("mir-10a", "mir-10b", "mir-196a-1", "mir-196a-2" and "mir-196b"). The "mir-10a" gene is located upstream of "Hoxb4" and the "mir-10b" gene is located upstream of "Hoxd4". Zebrafish have seven Hox gene clusters, genes encoding miR-10 ("mir-10a", "mir-10b-1", "mir-10b-2" and "mir-10c") are found in the Hox Ba, Bb, Ca and Da clusters. A fourth miR-10 gene ("mir-10d") is found elsewhere in the genome, at a location homologous to the pufferfish HoxDd cluster.