Germanías
In 1523 Charles V appointed the couple jointly viceroys of Valencia. There Germaine, recently returned to Spain, dealt with the fallout of the Revolt of the Brotherhoods by the Valencian guilds ("Germanies"). Germaine favored harsh treatment of the "agermanats"; she is thought to have signed the death warrants of 100 former rebels personally, and sources indicate that as many as 800 executions may have occurred in total. This undid the more lenient policy of Diego Hurtado de Mendoza, who had favored reconciliation with the rebels. In December 1524, Germaine signed a pardon that officially ended the persecution of all former participants in the rebellion. However, fines imposed on the guilds and guild-aligned cities as punishment would take many years to pay.