スティーブン・ストラスバーグ
Espino re-signed with the Nationals on a minor league contract on November 2, 2020. On April 18, 2021, Espino was selected to the active roster after Stephen Strasburg was placed on the injured list. On June 16, 2021, Espino won his first major league game, pitching five shutout innings in a 3-1 win over the Pittsburgh Pirates.