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Construction of the church was begun in 1643 with plans by Francesco Borromini, annexed to an Augustinian nunnery that was founded by Camilla-Virginia Savelli Farnese, Duchess of Latera. However, when the fortunes of the House of Farnese declined, so did the funding for the church, and by 1655 the work was stopped. The convent underwent a number of tribulations during the nineteenth century, however, it was not deconsecrated in 1873, as were many other monasteries. Since then, the nunnery has slowly ebbed and most of the convent is now the Hotel Donna Camilla Savelli. The Diocese presently lists the church as being in the care of the few remaining nuns of the order of "Suore Oblate del Santo Bambino Gesù". The monastery also served as a place to hide Jews from the fascist authorities active in the Holocaust during World War II.