Khosrau II
In 590, a member of the House of Mihran, Bahram Chobin repelled the newly ascended Sasanian ruler Khosrau II from Iraq, and conquered the region. One year later, Khosrau II, with aid from the Byzantine Empire, reconquered his domains. During his reign, some of the great fame of al-Mada'in decreased, due to the popularity of Khosrau's new winter residence, Dastagerd. In 628, a deadly plague hit al-Mada'in and the rest of the western part of the Sasanian Empire, which even killed Khosrau's son and successor, Kavadh II.