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In molecular biology, repeat-induced point mutation or RIP is a process by which DNA accumulates G:C to A:T transition mutations. Genomic evidence indicates that RIP occurs or has occurred in a variety of fungi while experimental evidence indicates that RIP is active in "Neurospora crassa", "Podospora anserina", "Magnaporthe grisea", "Leptosphaeria maculans", "Gibberella zeae" and "Nectria haematococca". In "Neurospora crassa", sequences mutated by RIP are often methylated "de novo".