Hokuto Shinken
The manga "Fist of the North Star" centers around the fictional martial art school called "Hokuto Shinken", whose practitioners are trained to kill or incapacitate opponents by striking the specific pressure points on an opponent's body. The protagonist of the story, Kenshiro, is the successor of this style and will often end a battle stating how much time the opponent has left to live after delivering a finishing move, or follow up with his famous catchphrase, "You are already dead", before his opponent dies, usually from violently exploding.