墨西哥航空
In 2000, Copa Airlines inaugurated service to Los Angeles, Cancún, and Orlando, as well as to São Paulo; in 2001, it began service to Quito, Ecuador. In 2004, it began service to John F. Kennedy International Airport in New York City. Copa also announced in August of that year a codeshare agreement with Mexico's Mexicana de Aviación, which lasted until 2007.