World Football Challenge
At club level, he made his debut for América on 4 February 2006 against Atlas. His debut in an international tournament came in 2007, when América participated in the Copa Sudamericana, where they finished runner-up. In 2009 América participated in the World Football Challenge, where he scored in the 2–1 win against AC Milan. In 2011 Esqueda scored against European clubs Manchester City in a 1–1 draw, and against Real Madrid in a 2–3 loss.