Mycobacterium leprae
Many species exhibit genome reduction when subsets of their genes are not needed anymore. This typically happens when organisms adapt to a parasitic life style, e.g. when their nutrients are supplied by a host. As a consequence, they lose the genes needed to produce these nutrients. In many cases, there are both free living and parasitic species that can be compared and their lost genes identified. Good examples are the genomes of "Mycobacterium tuberculosis" and "Mycobacterium leprae", the latter of which has a dramatically reduced genome.