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Catherine de Clèves (or de Nevers), Countess of Eu (1548 – 11 May 1633) was the wife of Henry, Duke of Guise, and matriarch of the numerous and influential House of Guise. By marriage she was Duchess of Guise from 1570 to 1588, and Dowager Duchess of Guise thereafter. She was Countess of Eu in her own right from 1564.