Dopamine receptor
D5 receptor is expressed more widely in the CNS than its close structural homolog dopamine receptor D1. It is found in neurons in amygdala, frontal cortex, hippocampus, striatum, thalamus, hypothalamus, basal forebrain, cerebellum, and midbrain. Dopamine receptor D5 is exclusively expressed by large aspiny neurons in neostriatum of primates, which are typically cholinergic interneurons. Within a cell, D5 receptors are found on the membrane of soma and proximal dendrites. They are also sometimes located in the neuropil in the olfactory region, superior colliculus, and cerebellum. D5 receptor is also found in striatal astrocytes of the rat basal ganglia.