Hephthalite Empire
The rise of new Persian power, the Sasanian Empire, saw them exert their influence into the Indus region and conquer lands from the Kushan Empire, setting up the Indo-Sasanians around 240 CE. They were to maintain their influence in the region until they were overthrown by the Rashidun Caliphate. Afterwards, they were displaced in 410 CE by the invasions of the Hephthalite Empire.