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Delany won leading roles in a string of feature films such as the TV movie "A Promise to Keep", "Light Sleeper", "Housesitter" and "Fly Away Home" as well as appearing in the TV mini-series "Wild Palms". She also took on controversial roles, such as Mistress Lisa in "Exit to Eden", where one film critic commented "The script was awful—Dana looked great." In 1992 she turned in her best known performance of the decade in the blockbuster "Tombstone" alongside Kurt Russell's Wyatt Earp, playing his love interest and future bride Josephine Marcus.