Kampong Cham Province
Srey Santhor district is a central district of Kampong Cham Province. Reading from the north clockwise, Srey Santhor shares a border with Kang Meas District of Kampong Cham to the north across the Mekong. Koh Sotin district lies on the eastern border. To the south are Sithor Kandal and Pea Reang districts of Prey Veng Province. The western border of the district is shared with Khsach Kandal district of Kandal Province.