Ridda wars
Muhammad died in 632 and Ikrima was meanwhile pardoned and played an active role, along with Khalid, in the suppression of the Arab tribes that defected from the Muslim state after Muhammad's death in the Ridda wars (632–633). Ikrima later died fighting Byzantine forces, possibly at the Battle of Ajnadayn, while other members of the Makhzum, al-Muhajir ibn Abi Umayya and Abd Allah ibn Abi Rabi'a ibn al-Mughira served various terms as governors of part or all of Yemen under the caliphs Abu Bakr () and Umar (). The most prominent role by a member of the Makhzum during this period was played by Khalid who scored key victories against Musaylima in the Yamama during the Ridda wars and against the Byzantines during the Muslim conquest of Syria (634–638). His son Abd al-Rahman was appointed governor of Homs and the Jazira and fought reputably against the Byzantines. The forty or so male descendants of Khalid died in a plague in Syria toward the end of Umayyad rule.