Mary (mother of Jesus)
The bishop of Salamis, Epiphanius, wrote too in his work "The Panarion" (AD 374-375) that "...James (brother of Jesus) was Joseph's son by Joseph's first wife, not by Mary..." He adds that Joseph became the father of James and his three brothers (Joses, Simeon, Judah) and two sisters (a Salome and a Mary or a Salome and an Anna) with James being the elder sibling. James and his siblings were not children of Mary but were Joseph's children from a previous marriage. After Joseph's first wife died, many years later when he was eighty, "he took Mary (mother of Jesus)". According to Epiphanius the Scriptures call them "brothers of the Lord" to confound their opponents.