イタリアダービー
Icardi started the season on 21 August by playing in the 2–0 away defeat to Chievo in the opening league match, and scored his first goal of the season a week later during the 1–1 draw against Palermo at home. On 11 September, Icardi scored both goals, including a last-minute winner, as Inter overturn the score against newly promoted side Pescara for the first win of the season under the new coach Frank de Boer. One week later, in the Derby d'Italia match against Juventus, Icardi scored an equalizer in the 68th minute, and provided the Ivan Perišić goal ten minutes later, as Inter overturn the score again to beat the lifetime rivals for the first time in league since November 2012. It was Icardi's seventh goal in eight appearances against Juventus.