Coeliac disease
DQA1 and DQB1 genes. Therefore, the DQA1, α, component is as important as DQB1. An example of this is DQ2, DQ2 mediates Coeliac disease and Type 1 diabetes but only if the α5 subunit is present. This subunit can be encoded by either DQA1*05:01 or DQA1*05:05. When the DQ2 encoding β-chain gene is on the same chromosome as the α5 subunit isoform, then individuals