Санти-Куаттро-Коронати
On 16 March 1863, aged 57, he was appointed Cardinal-Priest of Santi Quattro Coronati and elevated to the Cardinalate. On 15 July 1878, he was promoted Cardinal-Bishop of Palestrina by Pope Leo XIII He was named Vice-Chancellor of the Holy Roman Church on the same day, and was granted the titular church of S. Lorenzo in Damaso held "in commendam" (under administration), a church to which a Vice-Chancellor was usually assigned. He was appointed Prefect of the Congregation for Studies on 13 August 1878.