Santa Ana de Coro
In accordance with his contract, Welser armed a fleet, which sailed from Sanlúcar de Barrameda early in 1528, under the command of Ambrosius Ehinger, whom he appointed captain general. The Welsers set up a colonization scheme and sent Ehinger as governor to Santa Ana de Coro (), the capital of the Province of Venezuela. Ehinger left Seville on 7 October 1528 with the Spaniard and 281 settlers. At Santo Domingo, de Lerma with 50 companions left for Santa Marta, to reestablish Spanish control following the murder of the governor there. Ehinger and the remainder headed for the Venezuelan coast and landed on 24 February 1529 at Santa Ana de Coro. Almost immediately Ehinger replaced his Welser-appointed Spanish deputy González de Leyva with Nicolaus Federmann.