Seleucid Empire
The loss of so much territory sent the already enfeebled empire into a decline from which it could never recover. The Seleucid Empire became a rump state which consisted of little more than Antioch and the surrounding lands. The only reason the Seleucid Empire continued to exist is because the Parthians saw it as a useful buffer against the Roman Empire. When Pompey led a Roman expedition into Syria, he annexed the Seleucid Empire, and the stage was set for the Roman–Parthian Wars.