Reactive oxygen species
Some of the inhibitory effects of 15("S")-HpETE and 15("S")-HETE, particularly when induced by high concentrations (e.g. &gt;1-10 micromolar), may be due to a less specific mechanism: 15("S")-HpETE and to a lesser extent 15("S")-HETE induce the generation of Reactive oxygen species. These species trigger cells to activate their death programs, i.e. apoptosis, and/or are openly toxic to the cells. 15("S")-HpETE and 15(S)-HETE inhibit angiogenesis and the growth of cultured human chronic myelogenous leukemia K-562 cells by a mechanism that is associated with the production of reactive oxygen species.