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In 256, Tang Zi joined Wen Qin, Lü Ju, Liu Zuan () and Zhu Yi to resist a Wei invasion in the regions around the Huai and Si rivers (in present-day Anhui). In the same year, after the Wu regent Sun Jun died, Tang Zi sided with Sun Jun's cousin Sun Chen in a power struggle and killed Lü Ju, thus clearing the way for Sun Chen to succeed Sun Jun as the regent of Wu.