Theory of mind
The brain regions associated with theory of mind include the superior temporal gyrus (STS), the temporoparietal junction (TPJ), the medial prefrontal cortex (mPFC), the precuneus, and the amygdala. The reduced activity in the mPFC of individuals with schizophrenia is associated with the Theory of mind deficit and may explain impairments in social function among people with schizophrenia. Increased neural activity in mPFC is related to better perspective-taking, emotion management, and increased social functioning. Disrupted brain activities in areas related to theory of mind may increase social stress or disinterest in social interaction, and contribute to the social dysfunction associated with schizophrenia.