Province of South Carolina
Henry Middleton was born in 1717 on the family plantation, "The Oaks", near Charleston, Province of South Carolina. He was the second son of Susan (née Amory) Middleton (1690-1722) and Arthur Middleton (1681–1737), a wealthy planter who had served as an acting governor of South Carolina. His grandfather, Edward Middleton, emigrated from England via Barbados.