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In 1961, Eisenberg was hired at Hanna-Barbera Productions, run by former MGM cartoon producers William Hanna and Joseph Barbera. Here, Eisenberg co-created "The Peter Potamus Show", designed the characters on "Wacky Races" and "Super Friends", and worked in layout on programs such as "The Jetsons", "The Huckleberry Hound Show", "Jonny Quest", and "Wacky Races". In 1977, Hanna-Barbera alumnae Joe Ruby and Ken Spears started their own studio, Ruby-Spears Productions, and hired Eisenberg as producer and character designer for "Fangface", "The Plastic Man Comedy/Adventure Show", and "Thundarr the Barbarian".