Epidermal growth factor
Induction of Mig-7 expression occurs downstream of Epidermal growth factor/Epidermal growth factor receptor, Cox-2/PGE-2 or Hepatocyte growth factor/c-Met activation and signalling. Data has shown that Mig-7 expression is specific to human embryonic/fetal cytotrophoblast cells and epithelial type cancer cells, while not expressed in normal cells. Data demonstrate that targeting of Mig-7 simultaneously inhibits more than one cancer-progressing pathway while likely sparing normal cells.