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Positive feedback is a well studied phenomenon in gene regulation, where it is most often associated with bistability. Positive feedback occurs when a gene activates itself directly or indirectly via a double negative feedback loop. Genetic engineers have constructed and tested simple positive feedback networks in bacteria to demonstrate the concept of bistability. A classic example of positive feedback is the lac operon in "E. coli". Positive feedback plays an integral role in cellular differentiation, development, and cancer progression, and therefore, positive feedback in gene regulation can have significant physiological consequences. Random motions in molecular dynamics coupled with positive feedback can trigger interesting effects, such as create population of phenotypically different cells from the same parent cell. This happens because noise can become amplified by positive feedback. Positive feedback can also occur in other forms of cell signaling, such as enzyme kinetics or metabolic pathways.