RNA interference
In "Drosophila" RNA interference pathways, Hop has been shown to be an integral part of the pre-RISC complex for siRNAs. In the "Drosophila" Piwi-interacting RNA pathway, the RNA interference pathway responsible for the repression of transposable elements (transposons), Hop has been shown to interact with Piwi, and in the absence of Hop, transposons are derepressed, leading to severe genomic instability and infertility.