Battle of Anegawa
Later in 1570, at Battle of Anegawa while under attack from Asai forces under Isono Kazumasa, he lost his son Sakai Kyūzō. Masahisa was also present at the Siege of Odani (1573). Masahisa died soon after, at the Battle of Katada. Family headship was thus inherited by his second son, Sakai "Etchū no kami".