ステート・カレッジ・スパイクス
Holt began his professional career with the Pittsburgh Pirates' short season, Class-A affiliate, the State College Spikes, before advancing to the High-A Bradenton Marauders in 2010. His 2010 season was cut short due to injury to his medial collateral ligament, which required surgery. He began the 2011 season with the Pirates' Double-A affiliate, the Altoona Curve. On July 13, 2011, Holt was named the MVP of the Eastern League All-Star Game after hitting a two-run homer in the ninth inning.