Imperio de Ghana
Kayes Region (Bambara: ߞߊߦߌ ߘߌߣߋߖߊ tr. Kayi Dineja) is one of eight first level national subdivisions in Mali called Regions. It is the first administrative area of Mali and covers an area of . Its capital is the town of Kayes. The province was historically part of the Ghana Empire and the Mali Empire.