Battle of Issus
The Battle of Issus (also Issos) occurred in southern Anatolia, on November 5, 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III. It was the second great battle of Alexander's conquest of Asia, and the first encounter between Darius III and Alexander the Great. The battle resulted in the Macedonian troops defeating the Persian forces.