Donald James Cram (22.4.1919 – 17.6.2001) la nha hoa hoc nguoi My đa đoat giai Nobel Hoa hoc nam 1987, chung voi Jean-Marie Lehn va Charles J. Pedersen "cho cong trinh cua ho ve phat trien va su dung cac phan tu co nhung tac đong qua lai giua cac cau truc chuyen biet cua kha nang chon loc cao". Ho la nhung nguoi sang lap ra lanh vuc Hoa hoc chu-khach.


Tieu su Cram đuoc sinh ra va lon len o Chester, Vermont, trong mot gia đinh nhap cu. Cha ong la nguoi Scotland, con me ong la nguoi Đuc. Cha ong qua đoi truoc khi ong đuoc 4 tuoi. Ong lon len nho chuong trinh Aid to Families with Dependent Children, va hoc lam viec tu khi con nho, nhu hai trai cay, giao bao bang cach quang vao truoc nha nguoi ta, va son nha cua cho nguoi ta đoi lay viec hoc đan duong cam. Khi đuoc 8 tuoi, ong đa lam it nhat la 18 cong viec khac nhau.
Cram theo hoc truong trung hoc Winwood High School o Long Island, New York.
Tu nam 1938 toi 1941, ong hoc truong Rollins College o Winter Park, Florida nho mot hoc bong danh du quoc gia, noi ong lam viec nhu nhan vien phu ta trong phan khoa hoa hoc, va tham gia hoat đong kich nghe, ca đoan nha tho, cac hoi sinh vien Lambda Chi Alpha, Phi Society, cung Zeta Alpha Epsilon. Chinh tai Rollins ma ong noi tieng ve viec lam ra trang thiet bi hoa hoc cua rieng minh. Nam 1941, ong đau bang cu nhan hoa hoc.
Nam 1942, ong đau bang thac si nganh hoa huu co o Đai hoc Nebraska–Lincoln, voi luan van "Amino ketones, mechanism studies of the reactions of heterocyclic secondary amines with -bromo-, -unsaturated ketones", duoi su co van cua Norman O. Cromwell.
Nam 1947, Cram đau bang tien si nganh hoa huu co o Đai hoc Harvard, voi luan an mang ten "Syntheses and reactions of 2-(ketoalkyl)-3-hydroxy-1,4-naphthoquinones" duoi su huong dan cua Louis Fieser.


Su nghiep Tu nam 1942 toi 1945, Cram lam nghien cuu hoa hoc o cac phong thi nghiem cua Merck & Co, nghien cuu ve penicillin duoi su co van cua Max Tishler. Ong la nghien cuu sinh sau tien si cua Hoi Hoa hoc Hoa Ky tai Hoc vien Cong nghe Massachusetts, voi John D. Roberts. Cram la nguoi khoi xuong quy luat Cram, đua ra mot mo hinh đe du đoan ket qua viec tan cong ai luc hat nhan (nucleophilic attack) cua cac hop chat carbonyl. Ong đa xuat ban hon 350 bai khao cuu khoa hoc va 8 sach ve hoa huu co, cung day cac sinh vien sau cu nhan va sau tien si cua 21 quoc gia khac nhau.


= Nghien cuu =
 Cram đa mo rong cong trinh đot pha cua Charles J. Pedersen trong 'tong hop cac ete vong, cac hop chat huu co hai chieu co kha nang nhan biet va lua chon ket hop voi cac ion cua mot so nguyen to kim loai. Ong tong hop cac phan tu đa đua mon hoa hoc nay vao 3 chieu, tao ra mot mang cac phan tu co hinh dang khac nhau ma co the tuong tac co chon loc voi cac hoa chat khac vi cac cau truc 3 chieu bo sung cua chung. Cong trinh cua Cram la mot buoc tien lon toi su tong hop cac enzyme va cac phan tu tu nhien khac ma cach hoat đong hoa hoc đac biet la do cau truc đac trung cua chung. Ong cung nghien cuu ca Hoa hoc lap the. Quy luat Cram (cam ung khong đoi xung) đuoc đat theo ten ong.


= Giao su =
Cram đuoc bo nhiem lam giao su phu ta o Đai hoc California tai Los Angeles nam 1947, tro thanh giao su chinh thuc nam 1955 va đa lam viec o đay toi nam 1987. Ong thuong gay đan guitar va hat cac bai dan ca đe mua vui cho cac sinh vien trong lop.


Đoi tu Nguoi vo đau cua ong la Jean Turner, mot ban hoc cung lop o Rollins College, cung đau bang cu nhan nam 1941, roi bang thac si xa hoi hoc o Đai hoc Columbia. Nguoi vo thu hai la Jane, cuu giao su hoa hoc o Mt. Holyoke College. Cram chon khong sinh con "vi toi se la mot nguoi cha toi hoac mot nha khoa hoc kem coi".
Nam 2001, Cram qua đoi vi benh ung thu o tuoi 82.


Tac pham Cram, Donald J. (1994). Container Molecules and their Guests. Jane M. Cram. Great Britain: Royal Society of Chemistry. tr. 223 pp. ISBN 0854045074.
Cram, Donald J. (1990). From Design to Discovery. Washington, DC: American Chemical Society. tr. 146pp.
Cram, Jane M. (1978). The Essence of Organic Chemistry. Donald J. Cram. Reading, Massachusetts: Addison-Wesley. tr. 456pp.
Hendrickson, James B. (1970). Organic Chemistry. Donald J. Cram, George S. Hammond. Reading, Massachusetts: McGraw-Hill. tr. 1279pp. 3rd ed.
Richards, John (1967). Elements of organic chemistry. Don Cram, George S. Hammond. New York: McGraw-Hill. tr. 444pp.
Cram, Donald J. (1965). Fundamentals of Carbanion Chemistry. New York: Academic Press. tr. 289pp.
Cram, Donald J. (1964). Organic Chemistry. George S. Hammond. New York: McGraw-Hill. tr. 846pp. 2nd ed.
Cram, Donald J. (1959). Organic Chemistry. George S. Hammond. New York: McGraw-Hill. tr. 712pp. 1st ed.


Giai thuong va Vinh du Giai Hoa hoc cua Vien Han lam Khoa hoc quoc gia Hoa Ky
Giai thuong Nha nuoc ve Khoa hoc, Hoa Ky, 1993
Vien si Vien Han lam Khoa hoc quoc te
Giai Tolman cua Hoi Hoa hoc Hoa Ky, 1984
Giai Willard Gibbs, 1985
Giai Arthur C. Cope, 1974
Vien si Vien Han lam Khoa hoc va Nghe thuat Hoa Ky, 1967
"Giai thuong cho Cong trinh sang tao trong Hoa huu co tong hop" cua Hoi Hoa hoc Hoa Ky, 1965
Vien si Vien Han lam Khoa hoc quoc gia Hoa Ky, 1961
Giai Nobel Hoa hoc 1987


Tham khao & Chu thich Lien ket ngoai Nobelprize.org, Giai Nobel Hoa hoc 1987
Nobel Prize Donald Cram autobiography
Rollins College Biography Luu tru ngay 27 thang 12 nam 2007 tai Wayback Machine
Donald Cram: A Life in Pictures, UCLA Department of Chemistry and Biochemistry. (A tribute in pictures and collected speeches.) Luu tru ngay 20 thang 7 nam 2008 tai Wayback Machine
Harlan Lebo and Stuart Wolpert, UCLA News, "Donald Cram, Nobel Laureate and UCLA Chemist, Dies at 82,'" undated.
University of California in memoriam Luu tru ngay 6 thang 12 nam 2008 tai Wayback Machine
Donald Cram quotations from the BrainyQuote Web site.