Thuyet noi cong sinh la mot hoc thuyet tien hoa đe cap đen nguon goc cua cac te bao nhan chuan tu. Hoc thuyet nay lan đau tien đuoc đua ra boi nha thuc vat hoc Nga Konstantin Mereschkowski vao nam 1905 va 1910, va đuoc ho tro boi bang chung vi sinh cua Lynn Margulis vao nam 1967. Thuyet nay cho rang mot so bao quan phan biet o te bao nhan thuc la tien hoa qua cac sinh vat nhan so (vi khuan va vi sinh vat co) noi cong sinh.
Thuyet noi cong sinh cho rang ty the, lap the nhu luc lap, va co the mot so bao quan khac trong te bao nhan chuan la đai dien te bao nhan so tung song tu do truoc đay va chiem cho trong mot te bao nho noi cong sinh. Cu the hon, ty the co the la vi khuan hieu khi co đai kieu nhu Rickettsiales proteobacteria, con luc lap thi la vi khuan lam co đai co kha nang quang hop.

Đa co nhieu chung cu ho tro cho hoc thuyet nay, ta co the điem qua nhu: ty the va lap the chi nhan len thong qua truc phan, con te bao thi khong the tong hop moi bao quan nay; cac protein van chuyen đuoc goi la porin đuoc tim thay trong mang ngoai cua ti the, luc lap va mang te bao vi khuan; hop chat cardiolipin chi đuoc tim thay o mang trong ty the va mang te bao vi khuan; mot so ti the va lap the chua cac phan tu DNA dang vong, tran tuong tu nhu nhiem sac the cua vi khuan.


Bang chung Co nhieu bang chung ung ho rang ti the va lap the (bao gom ca luc lap) co nguon goc tu cac vi khuan.

Cac ti the va lap the moi chi đuoc hinh thanh thong qua truc phan, dang phan bao đuoc su dung boi vi khuan va vi sinh vat co.
Neu ti the hoac luc lap cua te bao đuoc loai bo, te bao khong co phuong tien đe tao moi nhung bao quan nay. Vi du, o mot so loai tao, chang han nhu Euglena, cac lap the co the bi pha huy boi mot so hoa chat hoac do thieu anh sang keo dai ma khong anh huong đen te bao. Trong truong hop nay, cac lap the se khong tai sinh.
Cac protein van chuyen đuoc goi la porin đuoc tim thay trong mang ngoai cua ty lap the va luc lap, cung đuoc tim thay tren mang cua te bao vi khuan.
Mot lipid mang la cardiolipin chi đuoc tim thay o mang trong ty the va mang te bao vi khuan.
Mot so ty the va mot so lap the chua cac phan tu DNA dang vong tuong tu nhu DNA cua vi khuan ca ve kich thuoc lan cau truc.
So sanh he gen cho thay moi lien he chat che giua ty the va vi khuan Rickettsial.
So sanh he gen cho thay moi quan he chat che giua lap the va vi khuan lam.
Nhieu gen trong bo gen cua ty lap the va luc lap đa bi mat hoac chuyen đen nhan cua te bao chu. Do đo, nhiem sac the cua nhieu sinh vat nhan chuan chua cac gen co nguon goc tu he gen cua ty the va lap the.
Ribosome cua ty the va lap the giong voi ribosome nhan so (70S) hon so voi cac sinh vat nhan chuan (80S).
Protein đuoc tao ra boi ty the va luc lap su dung N-formylmethionine lam amino acid khoi đau, đieu nay giong voi cac protein đuoc tao ra boi vi khuan chu khong phai cac protein đuoc tao ra boi cac gen cua te bao nhan chuan hoac vi sinh vat co.


Tham khao Đoc them Alberts, Bruce (2002). Molecular Biology of the Cell. New York: Garland Science. ISBN 0-8153-3218-1. (General textbook)
Brinkman, F. S., Blanchard, J. L., Cherkasov A, va đong nghiep (thang 8 nam 2002). "Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast". Genome Res. Quyen 12 so 8. tr. 1159–67. doi:10.1101/gr.341802. PMC 186644. PMID 12176923.
"Viral Theory and Endosymbiosis" (PDF). 1959. Ban goc (PDF) luu tru ngay 15 thang 7 nam 2011. Truy cap ngay 16 thang 9 nam 2018. {{Chu thich web}}: Đa bo qua tham so khong ro |authors= (tro giup) (Discusses theory of origin of eukaryotic cells by incorporating mitochondria and chloroplasts into anaerobic cells with emphasis on 'phage bacterial and putative viral mitochondrial/chloroplast interactions.)
Jarvis, P. (thang 4 nam 2001). "Intracellular signalling: the chloroplast talks!". Curr. Biol. Quyen 11 so 8. tr. R307–10. doi:10.1016/S0960-9822(01)00171-3. PMID 11369220. (Recounts evidence that chloroplast-encoded proteins affect transcription of nuclear genes, as opposed to the more well-documented cases of nuclear-encoded proteins that affect mitochondria or chloroplasts.)
"Organellar genes: why do they end up in the nucleus?". Trends Genet. Quyen 16 so 7. thang 7 nam 2000. tr. 315–20. doi:10.1016/S0168-9525(00)02053-9. PMID 10858662. {{Chu thich tap chi}}: Đa bo qua tham so khong ro |authors= (tro giup) (Discusses theories on how mitochondria and chloroplast genes are transferred into the nucleus, and also what steps a gene needs to go through in order to complete this process.)
"A secondary symbiosis in progress?". Science. Quyen 310 so 5746. thang 10 nam 2005. tr. 287. doi:10.1126/science.1116125. PMID 16224014. {{Chu thich tap chi}}: Đa bo qua tham so khong ro |authors= (tro giup)
Understanding Science Team. "Cells within cells: An extraordinary claim with extraordinary evidence" (PDF). University of California, Berkeley. Truy cap ngay 16 thang 2 nam 2014.


Lien ket ngoai Tree of Life Eukaryotes Luu tru ngay 29 thang 1 nam 2012 tai Wayback Machine