Inductively coupled plasma mass spectrometry

**Inductively coupled plasma mass spectrometry (ICP-MS)** is a type of mass spectrometry that helps scientists find and measure tiny amounts of elements in different types of samples, even down to parts per trillion, which is like finding one drop of ink in a million liters of water. It works by using a super-hot plasma (like a very hot gas made from ions) to break apart the sample and turn it into charged particles. Then, a mass spectrometer separates these particles by their mass and charge, and tells us what elements are there and how much of each is present. Because it is very sensitive, fast, and can measure many elements at once, ICP-MS is used in lots of areas: checking for pollution in air and water, studying rocks and soil, testing food and medicine for safety, researching nuclear materials, and developing new materials in science labs.

In ICP-MS, the sample, usually a liquid, first goes into a part called a nebulizer, which turns the liquid into a fine mist (like a spray). This mist is then sent into a super-hot plasma made from argon gas and heated by radio waves. The plasma gets as hot as 6,000 to 10,000 degrees Kelvin, hot enough to break the sample apart into atoms and turn those atoms into ions (charged particles). Next, these ions go into a vacuum chamber inside the mass spectrometer, where they are sorted by their mass and charge using special tools called mass analyzers (like quadrupole, time-of-flight, or sector field analyzers). Finally, the ions hit a detector (such as an electron multiplier or Faraday cup), which counts them and tells the scientist what elements are in the sample and how much of each is there.

ICP-MS is especially useful because it can measure many different elements at the same time, and it does this with very high sensitivity and accuracy, even when the sample is complicated or messy, like dirty water or biological fluids. It can also measure different versions of the same element, called isotopes (for example, carbon-12 vs. carbon-14). This is important in studies like figuring out the age of rocks (radiometric dating), investigating nuclear materials (nuclear forensics), or finding where pollution came from (source tracing). ICP-MS can detect almost every element on the periodic table, from the lightest ones like lithium to the heavy ones like uranium. When the instrument is set up and adjusted correctly (calibrated), there are very few problems with interference from other substances. To get the sample ready, scientists usually break it down using strong acids or special tools like microwave digestion. But in some cases, they can skip that step and use a method called laser ablation (LA-ICP-MS), which uses a laser to directly remove tiny amounts from a solid sample and send it into the ICP-MS for analysis.

One of the biggest advantages of ICP-MS compared to other tools like AAS (atomic absorption spectroscopy) or ICP-OES (optical emission spectroscopy) is that it can detect much smaller amounts of elements, even tiny traces, and it can also measure isotopes (different forms of the same element), which those other methods cannot do as well. However, ICP-MS is not perfect. Sometimes, it picks up interference (extra signals) that can make the results less accurate. These problems can come from things like polyatomic ions (when two or more atoms stick together and act like one), doubly charged ions (when ions have two charges instead of one), and isobaric overlaps (when two different elements have ions with the same mass). To fix this, modern ICP-MS machines often have special parts called collision or reaction cells (CRCs). These use special gases to break up or remove the interfering ions before they reach the detector. This helps make the results more accurate and reliable.

Since it was developed in the 1980s, ICP-MS has completely changed the way scientists detect tiny amounts of elements in all kinds of materials. It is one of the most powerful tools for this kind of work. ICP-MS is used in many fields. In environmental science, it checks for dangerous metals like lead or mercury in water, air, and soil. In medicine, it measures the amount of metals in the body, such as in blood, tissues, or medicine. In geology, it helps find valuable minerals and study how Earth formed, using isotopes. In food safety, it finds toxic elements like arsenic, cadmium, and lead in food. ICP-MS is also very important in making computer chips and high-tech materials, where even a tiny amount of contamination can cause big problems. The tool helps make sure materials are super pure and clean.

## Infobox (chemical analysis)

- **name**: Inductively coupled plasma mass spectrometry
- **image**: ICP-MS.jpg
- **caption**: ICP-MS Instrument
- **acronym**: ICP-MS
- **classification**: Mass spectrometry
- **analytes**: Nuclide, atomic and polyatomic chemical species, species in plasma, with exceptions; usually interpreted towards concentrations of Periodic table, chemical elements in sample
- **manufacturers**: Agilent, Bruker, Horiba, PerkinElmer, Shimadzu, SPECTRO Analytical Instruments, Spectro, Thermo Fisher Scientific, Thermo
- **related**: Inductively coupled plasma atomic emission spectroscopy
- **hyphenated**: Liquid chromatography-inductively coupled plasma mass spectrometry, Gas chromatography-inductively coupled plasma mass spectrometry