Evolutionary developmental biology

**Evolutionary developmental biology** interprets development in the light of evolution and modern genetics. It is called for short ***'evo-devo***'.

In _On the Origin of Species_ (1859), Charles Darwin proposed evolution through natural selection, a theory central to modern biology. Darwin recognised the importance of embryonic development in the understanding of evolution:
- "We can see why characters derived from the embryo should be of equal importance with those derived from the adult, for a natural classification of course includes all ages".

Ernst Haeckel (1866) proposed that "ontogeny recapitulates phylogeny", that is, the development of the embryo of every species (ontogeny) repeats the evolutionary development of that species (phylogeny). Haeckel's concept explained, for example, why humans, and indeed all vertebrates, have gill slits and tails early in embryonic development. His theory has since been largely discredited.

## The modern evolutionary synthesis

A renewed interest in the evolution of development came after the modern evolutionary synthesis (roughly 1936 to 1947). The conventional view had been that evo-devo had little influence on the evolutionary synthesis, but the following suggests otherwise.

### Gavin de Beer

In _Embryos and evolution_ (1930) Gavin de Beer stressed the importance of heterochrony, and especially paedomorphosis in evolution.

According to his theories, paedomorphosis (the retention of juvenile features in the adult form) is important in evolution because juvenile tissues are relatively undifferentiated and capable of further evolution, whereas highly specialised tissues are less able to change.

He also conceived the idea of _clandestine evolution_, which helped to explain the sudden changes in the fossil record which were apparently at odds with Darwin's gradualist theory of evolution.

If a novelty were to evolve gradually in an animal's juvenile form, then its development might not appear in the fossil record at all, but if the species were then to undergo neoteny, in which sexual maturity is reached while in a juvenile form, then the feature would appear suddenly in the fossil record, despite having evolved gradually.

- "In a series of remarkable books that established the synthetic theory of evolution, Gavin de Beer's _Embryology and evolution_ was the first and the shortest (1930; expanded and retitled _Embryos and ancestors_, 1940; 3rd ed 1958). In 116 pages de Beer brought embryology into the developing orthodoxy... for more than forty years, this book has dominated English thought on the relationship between ontogeny and phylogeny". Stephen Gould <sup>p221</sup>

Stephen Jay Gould called this approach to explaining evolution as _terminal addition_; as if every evolutionary advance was added as new stage by reducing the duration of the older stages. The idea was based on observations of neoteny. This was extended by the more general idea of heterochrony (changes in timing of development) as a mechanism for evolutionary change.

#### Neoteny and Man

It has often been suggested that the human species is, at least to some extent, an example of neoteny. These features of adult humans are different from those of adult great apes, but _more similar to those of juvenile apes_:

These are some of the neotenous traits in humans: flattened face, broadened face, large brain, hairless body, hairless face, small nose, reduction of brow ridge, small teeth, small upper jaw (maxilla), small lower jaw (mandible), thinness of skull bones, limbs proportionately short compared to torso length, longer leg than arm length, larger eyes, and upright stance.

Even more significant is the way that humans continue to learn and play into adult life, whereas in apes (and other mammals) this kind of behaviour is usually shown only in juveniles. This strongly suggest that our brain activities are, at least in this respect, more similar to juvenile apes than to adult apes.

### E.B. Lewis

Modern interest in evo-devo springs from clear proof that development is closely controlled by special genetic systems involving hox genes.

In a series of experiments with the fruit-fly _Drosophila_, Edward B. Lewis was able to identify a complex of genes whose proteins bind to the regulatory regions of target genes. The latter then activate or repress systems of cellular processes that accomplish the final development of the organism.

Furthermore, the sequence of these control genes show _co-linearity_: the order of the loci in the chromosome parallels the order in which the loci are expressed in segments along the body. Not only that, but this cluster of master control genes programs the development of all higher organisms.

Each of the genes contains a homeobox, a remarkably conserved DNA sequence, which is similar in many widely different animals. This suggests the complex itself arose by gene duplication. In his Nobel lecture, Lewis said "Ultimately, comparisons of the [control complexes] throughout the animal kingdom should provide a picture of how the organisms, as well as the [control genes] have evolved".

In 2000, a special section of the Proceedings of the National Academy of Sciences (PNAS) was devoted to evo-devo, and an entire 2005 issue of the Journal of Experimental Zoology Part B: Molecular and Developmental Evolution was devoted to the key evo-devo topics of evolutionary innovation and morphological novelty.

## Further reading

- Carroll, Sean B. 2005. _Endless forms most beautiful: the new science of evo devo_. New York: Norton.