Roderick MacKinnon

**Roderick MacKinnon** (born 19 February 1956) is a professor of Molecular Neurobiology and Biophysics at Rockefeller University. He won the Nobel Prize in Chemistry together with Peter Agre in 2003 for his work on the structure and operation of ion channels.

### Early life and education

MacKinnon was born in Burlington, Massachusetts and initially attended the University of Massachusetts Boston. MacKinnon then transferred to Brandeis University after one year, and there he received a bachelor's degree in biochemistry in 1978, studying calcium transport through the cell membrane for his honors thesis in Christopher Miller's laboratory. It was also at Brandeis where MacKinnon met his future wife and working-colleague Alice Lee.

After receiving his degree from Brandeis, MacKinnon entered medical school at Tufts University. He got his M.D. in 1982 and received training in Internal Medicine at Beth Israel Hospital in Boston. He did not feel satisfied enough with the medical profession, so in 1986 he returned to Christopher Miller's laboratory at Brandeis for postdoctoral studies.

### Career

In 1989 he was appointed assistant professor at Harvard University where he studied the interaction of the potassium channel with a specific toxin taken from scorpion venom. He learned how to purify proteins and to use X-ray crystallography. In 1996, he moved to Rockefeller University as a professor and head of the Laboratory of Molecular Neurobiology and Biophysics. There, he started to work on the structure of the potassium channel. These channels are of particular importance to the nervous system and the heart. The channels enable potassium ions to cross the cell membrane.

## Scientific contributions

Potassium channels demonstrate a  strange activity. They permit the passage of potassium ions, but they do not allow the passage of the much smaller sodium ions. Before MacKinnon's work, the detailed molecular architecture of potassium channels and the exact means by which they conduct ions was unknown. In 1998, despite barriers to the structural study of integral membrane proteins that had stopped most attempts for decades, MacKinnon and colleagues determined the three-dimensional molecular structure of a potassium channel from bacteria with X-ray crystallography. With this structure and other biochemical experiments, MacKinnon and colleagues were able to explain the exact mechanism by which potassium channel selectivity occurs.

His prize-winning research was conducted primarily at the Cornell High Energy Synchrotron Source of Cornell University, and at the National Synchrotron Light Source of Brookhaven National Laboratory.

## Awards and distinctions

- 1997 - Newcomb Cleveland Prize
- 1998 - W. Alden Spencer Award
- 1999 - Albert Lasker Award for Basic Medical Research
- 2000 - Elected to the U.S. National Academy of Sciences
- 2000 - Rosenstiel Award
- 2001 - Gairdner Foundation International Award
- 2003 - Louisa Gross Horwitz Prize from Columbia University
- 2003 - Nobel Prize in Chemistry

## Other websites

- Biography and Bibliographic Resources, from the Office of Scientific and Technical Information, United States Department of Energy
- Interview with Roderick MacKinnon by Harry Kroto Freeview video provided by the Vega Science Trust.
- Website of his lab at the Rockefeller University
- Ion Channel Chemistry: The Electrical System of Life  Transcribed video of a May 2008 talk by MacKinnon, sponsored by the Oregon State University Libraries.
- Nobel Lecture by Roderick MacKinnon, 2003

## Infobox (scientist)

- **name**: Roderick MacKinnon
- **image**: Roderick MacKinnon, M.D..jpg
- **image size**: 180px
- **birth place**: Burlington, Massachusetts, United States, USA
- **nationality**: United States
- **field**: Chemistry
- **alma mater**: Brandeis University
- **prizes**: Nobel Prize in Chemistry (2003),
 Albert Lasker Award for Basic Medical Research (1999),
 Louisa Gross Horwitz Prize (2003)