julilili42/papers huggingface dataset:
Limbajul drept orizont ludic universal
2013-01-01

Research Article| January 01 2013 Limbajul drept orizont ludic universal Dana Babin Dana Babin Philosophische Fakultät, Eberhard Karls Universität Tübingen, babindana@gmail.com. Search for other works by this author on: This Site Google Hiperboreea (2013) A2 (1-4): 21–30. https://doi.org/10.5325/hiperboreea.2.1-4.0021 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Dana Babin; Limbajul drept orizont ludic universal. Hiperboreea 1 January 2013; A2 (1-4): 21–30. doi: https://doi.org/10.5325/hiperboreea.2.1-4.0021 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressHiperboreea Search Advanced Search Denken und Sprache. Wenn sie nicht einig sind, dann wenigstens entsteht inzwischen eine innere Verbindung, die auf unseres ganze Leben wirkt. Als kulturelle Wesen bedeutet die Sprache für uns eine Ebene wo wir sogar bestimmen können, was für uns als Erfahrung möglich ist: sie eröffnet für uns eine Wahrheit, oder verbirgt sie. Mit disem Problem beschäftigen wir uns im Folgenden. Die Ergebnisse: nicht nur druckt die Sprache aus, die Art und Weise wie wir die Welt wahrnehmen, sondern hilft uns mehrere Ansichten und Erlebnisse uns eigen zu machen. Gândire și Limbă. Dacă nu sunt una și aceeași, atunci între ele apare cel puțin o legătură intrinsecă, ce se reflectă în întreaga noastră existență. Drept ființe culturale, limba reprezintă pentru noi un nivel unde putem determina ce este posibil ca experiență: ea deschide pentru noi un adevăr, sau dimpotrivă – îl ascunde. Asupra acestei probleme se apleacă textul de față. Rezultatele: limba nu exprimă doar felul în care noi percepem lumea ci ne ajută, în principiu, să obținem mai multe puncte de vedere și trăiri. Sprache, Denken, Schöpfung, Spiel, Heidegger, Nietzsche, Phänomen, aletheia, lethe, Wahrheitlimbaj, gândire, limba, lucruri, creatie, joc, heidegger, nietzsche, fenomen, adevar, aletheia-lethe The text of this article is only available as a PDF. Copyright © 2013 by The Pennsylvania State University. All rights reserved.2013The Pennsylvania State University Article PDF first page preview Close Modal You do not currently have access to this content.
Editors’ Introduction
2013-01-01

When Palgrave approached us with the proposal of editing the Handbook of International Trade targeted at the beginning postgraduate student, their rationale was the existence of a market niche supporting the teaching of the economics of international trade at either the masters or beginning doctoral level. Existing handbooks and surveys in international trade were primarily aimed at a research-oriented readership. When we contacted potential contributors we were encouraged by their willingness to join us in this endeavour. We are now delighted to introduce the finished product to teachers and students.
Miocene gneiss domes in the Pamir: linking graviational collapse of thickened crust to shortening in the Tajik foreland
2013-01-01

Cenozoic gneiss domes comprise one third of the surface exposure of the Pamir and allow an unparalleled view into deep crustal processes of the India–Asia collision. The largest of these is the ~350 × 90 km Shakhdara–Alichur dome of the southwestern Pamir, Tajikistan and Afghanistan. These composite gneiss domes exhumed crust from up to 30–40 km depth along two opposite-verging normal shear zones, the south-dipping South Pamir shear zone and the north-dipping Alichur shear zone. Smaller domes have been recognized in the central and northern Pamir. Comprehensive structural [1] and geochronologic and thermochronologic data [2] unravel the formation of the Shakhdara–Alichur gneiss domes by footwall exhumation of low-angle detachments. Crustal thickening in the Oligocene caused prograde metamorphism and peaked in widespread migmatization of the southwestern Pamir crust in the late Oligocene to early Miocene. The onset of doming at 21–20 Ma is attributed to graviational collapse of the weak, partially molten crust. Dome formation resulted in ≤90 km N–S extension in the southwestern Pamir at rates of ≤10 cm/yr in the Miocene and Pliocene; extensional doming ended at ~2 Ma. Isostatic surface uplift of the dome basement drove river incision at ≤1.0 mm/yr contrasting with low erosion rates (0.1–0.3 mm/yr) in the southeastern Pamir hanging wall cover; this contrast is reflected in the high-relief topography of the southwestern Pamir compared to eastern Pamir plateau. Overall, erosion of the basement domes was minor, preserving most of the extruded deep crust, including the top of the South Pamir shear zone at peak elevations throughout the dome. Extension in the Pamir is coeval with ongoing convergence between India and Asia. It opposes shortening in a fold-thrust belt north of the domes and in particular in the Tajik depression, where an evaporitic decollement facilitated upper crustal shortening. Gravitational collapse of the Pamir-plateau margin drove core-complex formation in the southwestern Pamir and shortening of the weak foreland adjacent to the plateau. Overall, this geometry defines a ‘vertical extrusion’ scenario, comprising frontal and basal underthrusting and thickening, and hanging gravitationally driven normal shear. The main difference between the Pamir and the Himalaya is the intense erosion of the Greater Himalayan crystalline rocks, which is in contrast to negligible erosion affecting the Pamir gneiss domes; this is an effect of a drastically different climatic scenario, with the Himalaya dominated by the Monsoon and the Pamir by the Westerlies.
Simulated and projected climate extremes in the Zhujiang River Basin, South China, using the regional climate model COSMO‐CLM
2013-01-02

ABSTRACT This study presents a detailed analysis of simulated and projected climate extremes in the Zhujiang River Basin (ZRB). Daily output from the regional climate model COSMO‐CLM ( CCLM ), driven by the ECHAM5 general circulation model, is used. The hindcast simulation covers the period from 1961 to 2000 while the projection concentrates on the near future period from 2011 to 2050. Spatio‐temporal statistical characteristics are investigated for three temperature and three precipitation indicators. The six simulated annual and monthly indicators are statistically compared with synoptic observations. The analysis is based on daily values of 195 grid points and 192 meteorological stations. The findings are presented and interpreted in terms of the model's capability. Compared to observations, slightly higher values for temperature indicators and slightly lower values for precipitation indicators are simulated. With the resulting good similarities in the spatial variation and trends, we conclude that CCLM is able to satisfyingly reproduce climate extreme for the simulated period. Therefore, our analyses show that CCLM can be used to project climate extremes in the ZRB for the period from 2011 to 2050. The projected changes indicate warmer and wetter conditions in the northern and southern regions, especially in winter and spring. This includes more intense rainfall events, which might potentially increase the risk of flooding in the central parts of the basin in these seasons. Warmer and dryer conditions can be expected in the western and eastern parts of the region, especially in summer and fall. These lower precipitation amounts but warmer temperatures will probably increase the evapotranspiration, which potentially leads to a higher risk of drought. Regarding these findings in climate extremes, adverse consequences in various sectors, such as agriculture, water, and energy should be anticipated.
Fiber pathways connecting cortical areas relevant for spatial orienting and exploration
2013-01-02

By implementing a task that closely resembled a clinical test for diagnosing spatial neglect in stroke patients, Himmelbach et al. ( : Neuroimage 32:1747–1759) found significantly increased activation during active exploration in those cortical areas in healthy subjects that are known to induce spatial neglect in case of a lesion. The present study investigated whether direct intra‐hemispheric cortico‐cortical connections could be found between these activated clusters using a probabilistic fiber‐tracking approach in 52 healthy subjects. We found that parts of the extreme capsule (EmC) and the middle longitudinal fascicle (MdLF) connected the functional cluster in the prefrontal cortex with the superior temporal cortex and the temporo‐parietal junction (TPJ) area in both hemispheres. The activation peak in the TPJ was additionally connected to the inferior frontal cortex by parts of the arcuate fascicle and the superior longitudinal fascicle (SLF II) in the right hemisphere. Our study elucidates the connections constituting the perisylvian network for spatial orienting and attention. Hence, we complement the knowledge from patients suffering from spatial neglect by giving first empirical evidence for the complete postulated network in healthy subjects. Hum Brain Mapp 35:1031–1043, 2014. © 2013 Wiley Periodicals, Inc.
Bugging Forecast: Unknown, Disliked, Occasionally Intimate. Bed Bugs in Germany Meet Unprepared People
2013-01-02

Bed bugs appear to be feared more than vector insects and other household pests. The reasons for this exaggerated fear are not fully understood. One hypothesis is that the folk knowledge on recognising and controlling bed bugs decreased as bed bugs became rarer in the 1960s and led to irrational perceptions. Here, we examine people's ability to recognise a bed bug and their response what to do in case of an infestation. We found that 13% of a sample of 391 people in four large German cities recognised a bed bug; 15% of all respondents would call a pest controller in case of bed bug infestation. This results in the pessimistic estimate that 97% of all early-stage infestations could go untreated. We discuss additional scenarios. The effectiveness of efforts to educate people about the presence of bed bugs has never been tested, but our sample is useful to guide future studies. We found three sources of information were associated with increased recognition rates of bed bugs: a) previous contacts with bed bugs (60% recognition), b) knowledge from friends or relatives (25%) and school or education courses (15%). By contrast, people who heard of bed bugs from television, print media or the Internet showed reduced recognition rates. We propose that the former factors be tested for educational interventions. In Germany, the bed bug is an estranged creature to many people, a fact that seems to hinder rational approaches to their control.
Peri-interventional combined anticoagulation and antithrombotic therapy in atrial fibrillation ablation: A retrospective safety analysis
2013-01-02

An additional antiplatelet therapy increases the risk of severe femoral bleeding events during CA of AF. It appears reasonable to perform the elective procedure of AF ablation after the dis-continuation of AAT.
Faculty Opinions recommendation of Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans.
2013-01-02

How small heat shock proteins (sHsps) might empower proteostasis networks to control beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that yeast sHsps, Hsp26 and Hsp42, inhibit prionogenesis by the [PSI+] prion protein, Sup35, via distinct and synergistic mechanisms. Hsp42 prevents conformational rearrangements within molten oligomers that enable de novo prionogenesis and collaborates with Hsp70 to attenuate self-templating. By contrast, Hsp26 inhibits self-templating upon binding assembled prions. sHsp binding destabilizes Sup35 prions and promotes their disaggregation by Hsp104, Hsp70, and Hsp40. In yeast, Hsp26 or Hsp42 overexpression prevents [PSI+] induction, cures [PSI+], and potentiates [PSI+]-curing by Hsp104 overexpression. In vitro, sHsps enhance Hsp104-catalyzed disaggregation of pathological amyloid forms of α-synuclein and polyglutamine. Unexpectedly, in the absence of Hsp104, sHsps promote an unprecedented, gradual depolymerization of Sup35 prions by Hsp110, Hsp70, and Hsp40. This unanticipated amyloid-depolymerase activity is conserved from yeast to humans, which lack Hsp104 orthologues. A human sHsp, HspB5, stimulates depolymerization of α-synuclein amyloid by human Hsp110, Hsp70, and Hsp40. Thus, we elucidate a heretofore-unrecognized human amyloid-depolymerase system that could have applications in various neurodegenerative disorders. PMID: 22723742 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: 1R21NS067354-0110 NIH HHS, United States Grant ID: 1DP2OD002177-01 NIH HHS, United States Grant ID: DP2 OD002177
Respiratory Motion Correction in Oncologic PET Using T1-Weighted MR Imaging on a Simultaneous Whole-Body PET/MR System
2013-01-03

The proposed method for MR-based respiratory motion correction of PET data proved feasible and effective. The short examination time and convenience (no additional equipment required) of the method allow for easy integration into clinical routine imaging. Performance compared with gating procedures can be further improved using list-mode-based motion correction.
[Ge12{FeCp(CO)2}8{FeCp(CO)}2]: A Ge12 Core Resembles the Arrangement of the High‐Pressure Modification Germanium (II)
2013-01-03

Similar yet different: The reaction of a GeBr solution with K[FeCp(CO)2] (Cp=η-C5H5) gives [Ge12{FeCp(CO)2}8{FeCp(CO)}2] (1), whose oblong, highly cross-linked cluster core reveals a cut-out of the high-pressure solid-state structure of germanium (II) (see scheme). Mass spectrometric investigations on the gas-phase species [Ge6{FeCp(CO)2}6{FeCp(CO)}]− (2) and theoretical calculations on 1 and 2 illuminate the formation of the metalloid cluster 1. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The sulfonylurea receptor Sur is dispensable for chitin synthesis in Drosophila melanogaster embryos
2013-01-03

Abstract BACKGROUND Chitin produced by membrane‐inserted chitin synthases is an important constituent of the arthropod cuticle and midgut peritrophic matrix. Chitin synthesis inhibitors are common insecticides in pest control. As the target of sulfonylurea‐derived insecticides such as diflubenzuron, the ABC transporter sulfonylurea receptor (Sur) has been postulated to be an essential cofactor of chitin synthesis. However, direct evidence for this assumption is missing. RESULTS Here, a study has been made of the phenotype of Drosophila melanogaster larvae suffering completely eliminated Sur function. Taken together, it is found that cuticle architecture is normal and chitin amounts are not diminished in the cuticle of these animals, indicating that Sur is dispensable for chitin synthesis. CONCLUSION The data obtained suggest that there must exist another sulfonylurea‐sensitive ABC transporter that either instead of Sur is the true sulfonylurea‐sensitive transporter involved in chitin synthesis or is able to substitute Sur function during cuticle formation. Identification and characterisation of this factor is pivotal for understanding the mode of action of sulfonylurea as insecticide. © 2013 Society of Chemical Industry
NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca2+ Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar Artery
2013-01-03

Cochlear blood flow regulation is important to prevent hearing loss caused by ischemia and oxidative stress. Cochlear blood supply is provided by the spiral modiolar artery (SMA). The myogenic tone of the SMA is enhanced by the nitric oxide synthase (NOS) blocker L-N(G)-nitro-arginine (LNNA) in males, but not in females. Here, we investigated whether this gender difference is based on differences in the cytosolic Ca(2+) concentration and/or the Ca(2+) sensitivity of the myofilaments. Vascular diameter, myogenic tone, cytosolic Ca(2+), and Ca(2+) sensitivity were evaluated in pressurized SMA segments isolated from male and female gerbils using laser-scanning microscopy and microfluorometry. The gender difference of the LNNA-induced tone was compared, in the same vessel segments, to tone induced by 150 mM K(+) and endothelin-1, neither of which showed an apparent gender-difference. Interestingly, LNNA-induced tone in male SMAs was observed in protocols that included changes in intramural pressure, but not when the intramural pressure was held constant. LNNA in male SMAs did not increase the global Ca(2+) concentration in smooth muscle cells but increased the Ca(2+) sensitivity. This increase in the Ca(2+) sensitivity was abolished in the presence of the guanylyl cyclase inhibitor ODQ or by extrinsic application of either the nitric oxide (NO)-donor DEA-NONOate or the cGMP analog 8-pCPT-cGMP. The rho-kinase blocker Y27632 decreased the basal Ca(2+) sensitivity and abolished the LNNA-induced increase in Ca(2+) sensitivity in male SMAs. Neither LNNA nor Y27632 changed the Ca(2+) sensitivity in female SMAs. The data suggest that the gender difference in LNNA-induced tone is based on a gender difference in the regulation of rho-kinase mediated Ca(2+) sensitivity. Rho-kinase and NO thus emerge as critical factors in the regulation of cochlear blood flow. The larger role of NO-dependent mechanisms in male SMAs predicts greater restrictions on cochlear blood flow under conditions of impaired endothelial cell function.
Limb apraxia in acute ischemic stroke: A neglected clinical challenge?
2013-01-04

Symptoms of limb apraxia and executive dysfunctions are currently not explicitly considered by the National Institutes of Health Stroke Scale and, thus, not routinely tested by clinicians in the acute care of patients with suspected stroke. Neuropsychological testing, clinical examination, MRI, and functional magnetic resonance imaging (fMRI) were performed in a right-handed patient with acute onset of left-sided sensorimotor hemiparesis due to a right hemisphere ischemic stroke. Deficits in the execution of meaningless and meaningful gestures were not detected properly on initial clinical examination but were revealed later on through neuropsychological testing. Instead, the patient's inability to respond to specific instructions in the acute care setting was mistaken to reflect severe deficits in auditory comprehension. fMRI revealed right-hemispheric localization of language in the right-handed patient. We suggest including a bedside test for limb apraxia symptoms in acute clinical care of stroke patients. The distinction between deficits in limb praxis and impairments of language can be complicated owing to the common hemispheric co-localization of the two functions.
MSST observations of the pulsating sdB star PG 1605+072
2013-01-04

and the MSST+WET Teams ∗ Abstract. We present the first results from the MultiSite Spectroscopic Telescope (MSST) observations of the sdBV star PG 1605+072. Pulsating sdB stars (also known as EC14026 stars) offer the chance to gain new insights into the formation and evolution of extreme Horizontal Branch stars using the tools of asteroseismology. PG1605+072 is an outstanding object in its class, with the richest frequency spectrum, the longest periods, and the largest variations. The MSST campaign took place in May/June 2002 immediately following the Whole Earth Telescope Xcov22 run, which observed PG 1605+072 as an alternate target. We will first give an overview of the project and its feasibility, after which we will present the massive data set, made up of 399 hours of photometry and 151 hours of spectroscopy. The overall aims of the project are to examine light/velocity amplitude ratios and phase differences, changes in equivalent width/line index, and λ-dependence of photometric amplitudes, and to use these properties for mode identification.
Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate
2013-01-05

Toxin-antitoxin (TA) systems are small genetic elements found on plasmids or chromosomes of countless bacteria, archaea, and possibly also unicellular fungi. Under normal growth conditions, the activity of the toxin protein or its translation is counteracted by an antitoxin protein or noncoding RNA. Five types of TA systems have been proposed that differ markedly in their genetic architectures and modes of activity control. Subtle regulatory properties, frequently responsive to environmental cues, impact the behavior of TA systems. Typically, stress conditions result in the degradation or depletion of the antitoxin. Unleashed toxin proteins impede or alter cellular processes including translation, DNA replication, or ATP or cell wall synthesis. TA toxin activity can then result in cell death or in the formation of drug-tolerant persister cells. The versatile properties of TA systems have also been exploited in biotechnology and may aid in combating infectious diseases.
Metabolic Mapping of Gliomas Using Hybrid MR-PET Imaging
2013-01-05

Metabolic mapping before histological sampling is feasible using simultaneous MR-PET imaging. High T/N Met uptake ratio reflecting high expression of amino-acid membrane transporters, which is indicative of proliferating tumor cell populations, does not always spatially correlate with neuronal cell loss and cell membrane proliferation (Cho/NAA) seen in MRS. Increased Cr/NAA is associated with increased methionine uptake in low-grade gliomas, whereas normalized creatine in tumor tends to correlate with methionine accumulation, which indicates a possible coupling of these metabolic indices in anaplastic tumors. Thus, spatial distribution differences in gliomas should be taken into account when planning surgical sampling.
Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation
2013-01-07

Abstract Experimental mouse models of bacterial skin infections that have been described show that pathogenic microorganisms can readily invade the epidermis and dermis to produce localized infections. We used an epicutaneous mouse skin infection model to determine how the level of barrier disruption by tape‐stripping correlates with persistence of S taphylococcus aureus skin colonization, concomitant induction of cutaneous inflammation and infection. Furthermore, we investigated how murine skin responds to S . aureus colonization in a physiologic setting by analysing proinflammatory cytokines and antimicrobial peptides in mouse skin. We show that previous cutaneous damage allows skin inflammation to develop and favours S . aureus persistence leading to cutaneous colonization, suggesting an interdependence of cutaneous bacteria and skin. Our study suggests that skin barrier defects favour S . aureus skin colonization, which is associated with profound cutaneous inflammation.
Optical properties of fully and partially fluorinated rubrene in films and solution
2013-01-07

We present the optical properties of fully (C42F28, PF-RUB) and half-fluorinated (C42F14H14, F14-RUB) rubrene, both in thin films and as monomers in solution and compare them to hydrogenated rubrene (C42H28, RUB). All three compounds show similar optical absorption bands and photoluminescence line shapes. The results are interpreted with density functional calculations of the orbital energies and time-dependent density functional theory for the HOMO-LUMO transition. Red shifts induced by the surrounding solvent or organic thin films remain much smaller than for polyacenes, in keeping with previous observations for rubrene and existing models for the solvatochromic shifts.