julilili42/papers huggingface dataset:
Reflection Spectra of Accretion Disks Illuminated by Disk-like Coronae
2022-01-01

Abstract Relativistic reflection features in the X-ray spectra of black hole binaries and active galactic nuclei are thought to be produced through illumination of a cold accretion disk by a hot corona. In this work, we assume that the corona has the shape of an infinitesimally thin disk with its central axis the same as the rotational axis of the black hole. The corona can either be static or corotate with the accretion disk. We calculate the disk’s emissivity profiles and iron line shapes for a set of coronal radii and heights. We incorporate these emissivity profiles into relxill _ nk and we simulate some observations of a black hole binary with the Nuclear Spectroscopic Telescope Array to study the impact of a disk-like coronal geometry on the measurement of the properties of the system, and in particular, on the possibility of testing the Kerr nature of the source. We find that, in general, the astrophysical properties of the accretion disk are recovered well even if we fit the data with a model employing a broken power law or a lamppost emissivity profile, while it is more challenging to constrain the geometric properties of the black hole spacetime.
Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma
2022-01-01

<b>Background:</b> Antibodies targeting surface expressed disialoganglioside GD2 are increasingly used in neuroblastoma immunotherapy and might also have potential for use in radioimmunotherapy. As such targeted treatments might benefit from a dedicated theranostic approach, we studied the influence of radiolabeling on the binding characteristics of ch14.18 antibodies produced by Chinese hamster ovary (CHO) cells and evaluated the benefit of GD2-ImmunoPET as a potential tool for therapy planning. <b>Methods:</b><sup>64</sup>Cu was used to reduce radiation burden, which is of high importance especially in a pediatric patient population. <sup>64</sup>Cu-labeling was accomplished using the chelators NOTA- or DOTAGA-NCS. Radiolabeled antibodies were characterized <i>in vitro</i>. [<sup>64</sup>Cu]Cu-DOTAGA-ch14.18/CHO was studied in a neuroblastoma mouse model (subcutaneous CHP-134 xenografts). <i>In vivo</i> PET and MR images were acquired at 3 h, 24 h, and 48 h p.i. The specificity of binding was verified using GD2-negative tumors (HEK-293 xenografts), a control antibody and <i>in vivo</i> blocking. A first translational application was performed by PET/MRI in a patient with metastasized neuroblastoma. <b>Results:</b> Radiolabeling at an antibody-to-chelator ratio ≥1:10 yielded a product with a radiochemical purity of ≥90% and a specific activity of 0.2-1.0 MBq/μg. Radiochelation was stable over 48 h in PBS, mouse serum or EDTA, and 50.8 ± 3.5% and 50.8 ± 2.0% of the radiolabeled conjugates, prepared at antibody-to-chelator ratios of 1:10 or 1:15, were immunoreactive. <i>In vivo,</i> highly specific accumulation (31.6 ± 5.8% ID/g) in neuroblastoma was shown preclinically. Clinical PET/MR scans using [<sup>64</sup>Cu]Cu-NOTA-ch14.18/CHO (NOTA used for safety reasons) could visualize neuroblastoma metastases. <b>Conclusions:</b><i>In vivo,</i><sup>64</sup>Cu-labeled ch14.18/CHO is suitable for specific identification of neuroblastoma in PET. A first patient PET indicated the feasibility of the method for clinical translation and the potential utility in image-guided therapy.
“Doing Transitions”: A New Research Perspective
2022-01-01

Abstract Life courses and the transitions that mark them are highly complex phenomena of social reproduction. Past research has been driven by institutional actors and policymakers concerned with mitigating problems such as social disadvantage and risks of exclusion. It has tried to reduce complexity to make it easier to observe and measure the effects of transitions on individual life trajectories. This chapter joins several other recent attempts to better address the complexities of life course by introducing a new framework – Doing Transitions – for understanding life course transitions, which also provides a foundation for the chapters of this book. This framework is inspired by a praxeological perspective, which takes as its starting point the proposition that transitions do not simply exist but are constantly constituted through social practices and the interrelation of social discourses, institutional regulation, and individual processes of learning, education, and coping. After describing the doing transitions framework, this chapter provides a brief overview of the volume and its contributions, which are organized around three themes: institutions and organizations; times and normativities; and materialities, such as bodies, spaces, and artefacts.
Right hemispheric white matter hyperintensities improve the prediction of spatial neglect severity in acute stroke
2022-01-01

White matter hyperintensities (WMH) are frequently observed in brain scans of elderly people. They are associated with an increased risk of stroke, cognitive decline, and dementia. However, it is unknown yet if measures of WMH provide information that improve the understanding of poststroke outcome compared to only state-of-the-art stereotaxic structural lesion data. We implemented high-dimensional machine learning models, based on support vector regression, to predict the severity of spatial neglect in 103 acute right hemispheric stroke patients. We found that (1) the additional information of right hemispheric or bilateral voxel-based topographic WMH extent indeed yielded a significant improvement in predicting acute neglect severity (compared to the voxel-based stroke lesion map alone). (2) Periventricular WMH appeared more relevant for prediction than deep subcortical WMH. (3) Among different measures of WMH, voxel-based maps as measures of topographic extent allowed more accurate predictions compared to the use of traditional ordinally assessed visual rating scales (Fazekas-scale, Cardiovascular Health Study-scale). In summary, topographic WMH appear to be a valuable clinical imaging biomarker for predicting the severity of cognitive deficits and bears great potential for rehabilitation guidance of acute stroke patients.
Are EU restrictive measures really targeted, temporary and preventive? The case of Belarus
2022-01-01

Questions related to the EU’s ability to foster change in the behaviour of third countries through sanctions have gained salience over the past three decades. This article explores how the nature and type of EU restrictive measures, initially conceived as targeted, preventive and temporary measures, have evolved considerably since then. The EU sanctions against Belarus are used as an illustrative case study in order to shed light on the evolutions within the EU’s sanctions practice. This article first examines the erosion of the targeted character of EU sanctions against Belarus through the broadening of listing criteria and the increasing recourse to sectoral sanctions. It then questions the temporary character of EU sanctions against Belarus by highlighting their indefinite duration and cyclicity. Last but not least, it is argued that EU sanctions against Belarus have an increasingly punitive character. The article concludes with an analysis of the implications that the EU’s evolving sanctions practice can have for the current EU’s sanctions policy toward Belarus as well as for its other sanctions regimes.
Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe
2022-01-01

Objective: To assess the current medical practice in Europe regarding prenatal dexamethasone (Pdex) treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency.\\n\\nDesign and methods: A questionnaire was designed and distributed, including 17 questions collecting quantitative and qualitative data. Thirty-six medical centres from 14 European countries responded and 30 out of 36 centres were reference centres of the European Reference Network on Rare Endocrine Conditions, EndoERN.\\n\\nResults: Pdex treatment is currently provided by 36% of the surveyed centres. The treatment is initiated by different specialties, that is paediatricians, endocrinologists, gynaecologists or geneticists. Regarding the starting point of Pdex, 23% stated to initiate therapy at 4–5 weeks postconception (wpc), 31% at 6 wpc and 46 % as early as pregnancy is confirmed and before 7 wpc at the latest. A dose of 20 μg/kg/day is used. Dose distribution among the centres varies from once to thrice daily. Prenatal diagnostics for treated cases are conducted in 72% of the responding centres. Cases treated per country and year vary between 0.5 and 8.25. Registries for long-term follow-up are only available at 46% of the centres that are using Pdex treatment. National registries are only available in Sweden and France.\\n\\nConclusions: This study reveals a high international variability and discrepancy in the use of Pdex treatment across Europe. It highlights the importance of a European cooperation initiative for a joint international prospective trial to establish evidence-based guidelines on prenatal diagnostics, treatment and follow-up of pregnancies at risk for CAH.
Emergent properties in supercrystals of atomically precise nanoclusters and colloidal nanocrystals
2022-01-01

An analogy is drawn between atoms in a nanocrystal and nanocrystals in a supercrystal with respect to their emergent optoelectronic properties. Recent results are discussed to illustrate the validity of this analogy and its application perspectives.
Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates
2022-01-01

We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed GO-2-Substrates, integrates protein function information, including GO terms from known substrates, with protein sequences to rank substrate candidates by similarity. We applied GO-2-Substrates to MALT1, a paracaspase and master regulator of NF-κB signalling in adaptive immune responses. With only 12 known substrates, the evolutionarily conserved paracaspase functions and phenotypes of <i>Malt1</i> <sup>-/-</sup> mice strongly implicate the existence of undiscovered substrates. We tested the ranked predictions from GO-2-Substrates of new MALT1 human substrates by co-expression of candidates transfected with the oncogenic constitutively active cIAP2-MALT1 fusion protein or CARD11/BCL10/MALT1 active signalosome. We identified seven new MALT1 substrates by the co-transfection screen: TANK, TAB3, CASP10, ZC3H12D, ZC3H12B, CILK1 and ILDR2. Using catalytically inactive cIAP2-MALT1 (Cys464Ala), a MALT1 inhibitor, MLT-748, and noncleavable P1-Arg to Ala mutant versions of each substrate in dual transfections, we validated the seven new substrates in vitro. We confirmed the cleavage of endogenous TANK and the RNase ZC3H12D in B cells by Western blotting and mining TAILS <i>N</i>-terminomics datasets, where we also uncovered evidence for these and 12 other candidate substrates by endogenous MALT1. Thus, protein function information improves substrate predictions. The new substrates and other high-ranked MALT1 candidate substrates should open new biological frontiers for further validation and exploration of the function of MALT1 within and beyond NF-κB regulation.
Case studies of the wind field around Ny-Ålesund, Svalbard, using unmanned aircraft
2022-01-01

The wind field in Arctic fjords is strongly influenced by glaciers, local orography and the interaction between sea and land. Ny-Ålesund, an important location for atmospheric research in the Arctic, is located in Kongsfjorden, a fjord with a complex local wind field that influences measurements in Ny-Ålesund. Using wind measurements from UAS (unmanned aircraft systems), ground measurements, radiosonde and reanalysis data, characteristic processes that determine the wind field around Ny-Ålesund are identified and analysed. UAS measurements and ground measurements show, as did previous studies, a south-east flow along Kongsfjorden, dominating the wind conditions in Ny-Ålesund. The wind measured by the UAS in a valley 1 km west of Ny-Ålesund differs from the wind measured at the ground in Ny-Ålesund. In this valley, we identify a small-scale catabatic flow from the south to south-west as the cause for this difference. Case studies show a backing (counterclockwise rotation with increasing altitude) of the wind direction close to the ground. A katabatic flow is measured near the ground, with a horizontal wind speed up to 5 m s-1. Both the larger-scale south-east flow along the fjord and the local katabatic flows lead to a highly variable wind field, so ground measurements and weather models alone give an incomplete picture. The comparison of UAS measurements, ground measurements and weather conditions analysis using a synoptic model is used to show that the effects measured in the case studies play a role in the Ny-Ålesund wind field in spring.
Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk
2022-01-01

Abstract We prove a generalised super-adiabatic theorem for extended fermionic systems assuming a spectral gap only in the bulk. More precisely, we assume that the infinite system has a unique ground state and that the corresponding Gelfand–Naimark–Segal Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that a similar adiabatic theorem also holds in the bulk of finite systems up to errors that vanish faster than any inverse power of the system size, although the corresponding finite-volume Hamiltonians need not have a spectral gap.
Body Composition of Preterm Infants following Rapid Transition to Enteral Feeding
2022-01-01

&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; This study aimed to evaluate body composition at the time of hospital discharge in very preterm infants following rapid transition to full enteral feeding. &lt;b&gt;&lt;i&gt;Study Design:&lt;/i&gt;&lt;/b&gt; We conducted a prospective, observational, cross-sectional study and included 105 preterm infants &amp;#x3c;32 gestational age or birth weight &amp;#x3c;1,500 g, born between April 2015 and December 2020, following rapid transition to full enteral feeding (≥140 mL/kg/day). Fat mass/total body mass (BF%) and fat-free mass (FFM) were measured at the time of hospital discharge using air displacement plethysmography. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Median and interquartile range (Q1–Q3) of gestational age at birth (GA) was 27.3 (26.1–28.7) weeks and birth weight 845 (687–990) g. Time to reach full enteral feeding was 5 (5–7) days. At 37.6 weeks (36.1–39.0) postmenstrual age (PMA), BF% was 17.0% (14.9–19.8) and FFM 2,161 g (1,966–2,432). BF% was not associated with GA, and not different between small and appropriate for gestational age infants. FFM was significantly lower in infants born small for gestational age. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Following rapid transition to full enteral feeding, FFM and BF% at discharge were similar to other preterm populations. BF% and FFM were not associated with GA at birth but with PMA at measurement. FFM was lower and BF% higher compared to term infants at birth, suggesting diminished parenchymal growth in preterm infants. Continued monitoring of body composition, metabolic health, and neurological development is needed to study long-term effects.
Archaeological sites and palaeoenvironments of Pleistocene West Africa
2022-01-01

African paleoanthropological studies typically focus on regions of the continent such as Eastern, Southern and Northern Africa, which hold the highest density of Pleistocene archaeological sites. Nevertheless, lesser known areas such as West Africa also feature a high number of sites. Here, we present a high-resolution map synthesising all well contextualised Pleistocene archaeological sites present in Sub-Saharan West Africa. A detailed elevation and ecoregional map was developed and correlated with palaeoanthropological sites. This map is supplemented with 1,000- and 2000-year interval climate reconstructions over the last 120,000 years for three subregions of high archaeological interest. The presented archaeological sites were compiled by reviewing published literature, and selected based on: (1) documented archaeological stratification or &gt;10 characteristic artefacts, (2) published coordinates, and (3) published chronometric ages or relative dating. The data presented here elucidates the current state of knowledge of Pleistocene West Africa, highlighting the regional potential for human evolutionary studies.
CLEVR-X: A Visual Reasoning Dataset for Natural Language Explanations
2022-01-01

Abstract Providing explanations in the context of Visual Question Answering (VQA) presents a fundamental problem in machine learning. To obtain detailed insights into the process of generating natural language explanations for VQA, we introduce the large-scale CLEVR-X dataset that extends the CLEVR dataset with natural language explanations. For each image-question pair in the CLEVR dataset, CLEVR-X contains multiple structured textual explanations which are derived from the original scene graphs. By construction, the CLEVR-X explanations are correct and describe the reasoning and visual information that is necessary to answer a given question. We conducted a user study to confirm that the ground-truth explanations in our proposed dataset are indeed complete and relevant. We present baseline results for generating natural language explanations in the context of VQA using two state-of-the-art frameworks on the CLEVR-X dataset. Furthermore, we provide a detailed analysis of the explanation generation quality for different question and answer types. Additionally, we study the influence of using different numbers of ground-truth explanations on the convergence of natural language generation (NLG) metrics. The CLEVR-X dataset is publicly available at https://github.com/ExplainableML/CLEVR-X .
Assessing sentence readability for German language learners with broad linguistic modeling or readability formulas: When do linguistic insights make a difference?
2022-01-01

We present a new state-of-the-art sentence-wise readability assessment model for German L2 readers. We build a linguistically broadly informed machine learning model and compare its performance against four commonly used readability formulas. To understand when the linguistic insights used to inform our model make a difference for readability assessment and when simple readability formulas suffice, we compare their performance based on two common automatic readability assessment tasks: predictive regression and sentence pair ranking. We find that leveraging linguistic insights yields top performances across tasks, but that for the identification of simplified sentences also readability formulas – which are easier to compute and more accessible – can be sufficiently precise. Linguistically informed modeling, however, is the only viable option for high quality outcomes in fine-grained prediction tasks. We then explore the sentence-wise readability profile of leveled texts written for language learners at a beginning, intermediate, and advanced level of German to showcase the valuable insights that sentence-wise readability assessment can have for the adaptation of learning materials and better understand how sentences’ individual readability contributes to larger texts’ overall readability.
Evaluation of patella height in native knees and arthroplasty: an instructional review
2022-01-01

Total knee arthroplasty (TKA) is the gold standard for treating advanced knee osteoarthritis. Among the postoperative complications of TKA are true patella infera (TPI) and pseudo patella infera (PPI), which should be differentiated since TPI exhibits significantly worse clinical outcomes. Multiple radiological patella height indices (PHI) exist; some were modified or originally designed for knees with implanted endoprostheses. However, there is no consensus on measuring and comparing patella height. Due to the lack of established, simple, reliable, and reproducible concepts for assessing patella height for arthroplasty, measuring patella height and the change of patella height by or after TKA have been challenging tasks for clinicians and researchers. This is a review of the current literature on methods for measuring patella height, with special attention to the ability to differentiate between the TPI and PPI after TKA. All literature on the topic was retrieved, and references from relevant articles were investigated until the end of April 2022.
Testing the Kerr black hole hypothesis with the continuum-fitting and the iron line methods: the case of GRS 1915+105
2022-01-01

Abstract The continuum-fitting and the iron line methods are currently the two leading techniques for probing the strong gravity region around accreting black holes. In the present work, we test the Kerr black hole hypothesis with the stellar-mass black hole in GRS 1915+105 by analyzing five disk-dominated RXTE spectra and one reflection-dominated Suzaku spectrum. The combination of the constraints from the continuum-fitting and the iron line methods has the potential to provide more stringent tests of the Kerr metric. Our constraint on the Johannsen deformation parameter α 13 is -0.15 &lt; α 13 &lt; 0.14 at 3σ, where the Kerr metric is recovered when α 13 = 0.
DYNAMICAL LOW-RANK APPROXIMATION FOR BURGERS' EQUATION WITH UNCERTAINTY
2022-01-01

Quantifying uncertainties in hyperbolic equations is a source of several challenges. First, the solution forms shocks leading to oscillatory behaviour in the numerical approximation of the solution. Second, the number of unknowns required for an effective discretization of the solution grows exponentially with the dimension of the uncertainties, yielding high computational costs and large memory requirements. An efficient representation of the solution via adequate basis functions permits to tackle these difficulties. The generalized polynomial chaos (gPC) polynomials allow such an efficient representation when the distribution of the uncertainties is known. These distributions are usually only available for input uncertainties such as initial conditions, therefore the efficiency of this ansatz can get lost during runtime. In this paper, we make use of the dynamical low-rank approximation (DLRA) to obtain a memory-wise efficient solution approximation on a lower dimensional manifold. We investigate the use of the matrix projector-splitting integrator and the unconventional integrator for dynamical low-rank approximation, deriving separate time evolution equations for the spatial and uncertain basis functions, respectively. This guarantees an efficient approximation of the solution even if the underlying probability distributions change over time. Furthermore, filters to mitigate the appearance of spurious oscillations are implemented, and a strategy to enforce boundary conditions is introduced. The proposed methodology is analyzed for Burgers’ equation equipped with uncertain initial values represented by a two-dimensional random vector. The numerical experiments validate that the results of a standard filtered Stochastic-Galerkin (SG) method are consistent with the numerical results obtained via the use of numerical integrators for dynamical low-rank approximation. Significant reduction of the memory requirements is obtained, and the important characteristics of the original system are well captured.