julilili42/papers huggingface dataset:
The co-design approach in the MIWOCA project
2019-11-01

Abstract MIWOCA study group Background The project MIWOCA researches how chronically ill women of Portuguese, Turkish and German origin and women without a migration background subjectively experience, understand, interpret and use the Swiss health care system. Methods We conducted 48 qualitative semi-structured interviews with chronically ill women between the ages of 23 and 85 in Bern and Geneva (n = 36 with German, Portuguese and Turkish migrant backgrounds) and n = 12 Swiss women. In addition, n = 12 stakeholder interviews were conducted (doctors, nurses, social workers, psychologists, physiotherapists). In focus groups with interviewed women in Bern and Geneva, results are reflected back, identified topics from the interviews prioritized and representatives named for the cooperative planning. In a participatory planning approach, affected women in the canton of Bern, together with stakeholders from the Swiss healthcare system selected by a systematic stakeholder analysis (e.g. Swiss Medical Association, Red Cross Switzerland, Spitex, Federal Office of Public Health), develop recommendations for improving the quality of care and concrete dissemination strategies. Results Interviewees had multiple and chronic diseases and resulting extensive experience with the Swiss healthcare system. Relevant aspects referred to issues such as quality of specific services, complexity of the healthcare system, costs of care, role of family and social support, and multidimensional stigmatization (migration, chronic illness, alleged overuse of the care system). Findings are incorporated in evidence briefs and narrative stories for focus groups and participatory planning. Conclusions MIWOCA contributes to a targeted and differentiated improvement of structures and options for action in health care for specific groups. Results will be relevant for planning in the health system and may be incorporated into academic teaching and practical training in PH, medicine and social sciences.
The Silicon Tracking System of the CBM Experiment at FAIR
2019-11-01

Abstract The Compressed Baryonic Matter (CBM) experiment at the future Facility for Antiproton and Ion Research (FAIR) aims to study the properties of nuclear matter at high net-baryon densities and moderate temperatures. The Silicon Tracking System (STS) is the key detector to reconstruct with a high efficiency up to 1000 charged particle trajectories created in heavy-ion collisions at interaction rates of up to 10 MHz. It will determine the momentum of the particles with a momentum resolution Δp/p ≈ 1-2% which requires ultra-low detector material budget of 0.3-1% X 0 per layer. The detector comprise eight layers of double-sided silicon micro-strip sensors and will be placed inside the 1 Tm superconducting magnet which limits the space available, which in turn requires advanced cooling approaches and mechanical design with precise tracking layers alignment. The micro-strip sensors have to be radiation hard and checked for their quality optically and electrically before the assembly. This contribution gives an overview of the STS and presents the status of its component quality control and assembly procedures.
Collaborative Mapping with Pose Uncertainties using different Radio Frequencies and Communication Modules
2019-11-01

Many robotic applications, especially exploration scenarios, benefit from deploying multiple collaborating robots with the aim of parallelizing and therefore accelerating the involved task. One critical part of a multi-robot system is its communication system. Depending on the application scenario, high-bandwidth wireless connections, such as WiFi, may not always be available and suffer from a limited communication range. On the other hand, low-bandwith systems require the application itself to deal with limited information exchange. In this work, we present a novel approach for collaborative mapping using mixtures of occupancy and NDT maps (called ONDT), which provide detailed information at low resolutions and in which the pose uncertainty can be encoded efficiently. Further, we compare the applicability of three different radio frequency modules operating at different frequencies in real world experiments with five robots at large distances.
Harmonizing Heterogeneous Diagnostic Data of a Vehicle Fleet for Data-Driven Analytics
2019-11-01

Data-driven technologies, such as predictive maintenance, become increasingly important to today's automotive industry due to advancements of connected cars and Over-the-Air technologies. A data source that has barely been used in the literature so far is diagnostic data, which is obtained by sending requests to the electronic control units of a vehicle. Diagnostic data can be collected cost-effectively and is already available on a large scale to car manufacturers today. However, the use of diagnostic data is associated with some difficulties. The set of measured variables differs greatly between different vehicles of the same type due to different configurations and therefore differences in the electronic control units. In this contribution, we show how diagnostic data can be harmonized for the use of data-driven modeling. An heuristic three-step procedure is introduced to identify similar measured variables. Finally, our approach is verified on a synthetic data set. Future data-driven technologies are able to use larger and more cost-efficient data sets this way.
CSIG-15. INHIBITION OF THE bHLH TRANSCRIPTIONAL NETWORKS BY A MUTATED E47 PROTEIN LEADS TO A STRONG ANTI-GLIOMA ACTIVITY IN VITRO AND IN VIVO
2019-11-01

Abstract OBJECTIVE The transcription factor E47 heterodimerizes with helix-loop-helix (HLH) and basic helix-loop-helix transcription (bHLH) factors like ID-1 and Olig2 that are overexpressed in glioblastoma. A dominant-negative variant of the E47 (dnE47) lacking the nuclear translocation signal, leads to cytoplasmatic sequestration of HLH and bHLH transcription factors. Here, we investigated combinations of dnE47-mediated inhibition of the bHLH transcriptional network with temozolomide and irradiation and explored the underlying molecular mechanisms. METHODS Long-term and stem cell glioma lines were transduced with a Doxycycline-inducible dnE47 lentivirus. Functional characterizations included immunocytochemistry, immunoblots, cytotoxicity and clonogenicity assays in vitro and latency until the onset of symptoms in vivo. CAGE and RNASeq were conducted for analyzing the dnE47-induced molecular profile. RESULTS The induction of dnE47 led to cytoplasmatic sequestration of HLH/bHLH transcription, reduced proliferation, increased cytotoxicity and reduced clonogenic survival in vitro and a prolonged latency until the onset of neurological symptoms in vivo. CAGE and RNASeq data revealed alterations in several cancer-relevant pathways. CONCLUSIONS A dnE47-mediated inhibition of the bHLH transcription network induced actionable molecular alterations in glioma cells that could be exploited for the design of novel therapies.
Towards overcoming the bottleneck of optimizing control parameters in finite element active human body models
2019-11-01

Abstract The number of Finite Element Active Human Body Model (FE aHBM) applications for the design and test of vehicle safety systems is growing. Primarily they are used for simulations of the accident pre‐crash phase where the influence of occupants active movements is significant. Such models are capable of accounting for dynamic human behaviour and reflexes by incorporating bio‐inspired muscle controllers. These controllers need to govern hundreds of active muscle elements during simulation in every time‐step thereby dramatically increasing runtime compared to passive HBMs. As runtime is an essential element of the entire research and development process of a new vehicle, new approaches for its reduction are required. The current contribution presents methods for the tuning of controller and active muscle element parameters using a reduced multibody (MB) model with a subsequent transfer to a fully deformable FE model.
P56 Comparison of the first 650 and the latest 524 laparoscopic transperitoneal pelvic/paraaortic lymphadenectomies in a series of 2535 patients treated for different gynaecological cancers
2019-11-01

<h3>Introduction/Background</h3> Lymphadenectomy is an integral part of operative staging and treatment of gynaecological malignancies. Since its introduction over 25 years ago, laparoscopic lymphadenectomy has proven to be feasible, safe and oncologically adequate in comparison to open surgery while morbidity is lower and hospital stay is considerably shorter. <h3>Methodology</h3> In this retrospective study we analysed our prospectively collected data of laparoscopic pelvic and/or paraaortic lymphadenectomies performed between 1994 and 2018 by one team of gynaecological oncology surgeons. Data was analysed with regards to operation time, intra- and postoperative complications, number of harvested lymph nodes and influence of BMI. Previously published data of the first 650 patients treated after introduction of the method between 1994 and 2003 (period 1) was compared with the data of the latest 524 patients treated between 2014 and 2018 (period 2). <h3>Results</h3> Indications for pelvic and/or paraaortic lymphadenectomies in the 2535 patients were cervical cancer, endometrial cancer, vulvar cancer with positive groin nodes, early ovarian cancer, vaginal cancer, uterine carcinosarcoma and others in a number of 1893, 361, 62, 99, 28, 13 and 79 patients, respectively. The learning curve for the two procedures was already completed during the first 650 cases. Since 1999 a steady and oncologically adequate number of lymph nodes were harvested in both areas independent of patients' BMI. OR-time for paraaortic lymph node dissection was shorter in period 2 (69 vs 100 min). In contrast to period 1 (2.9%), there were no intraoperative complications in period 2, whereas postoperative complications are similarly frequent (5.8 vs 7.6%). <h3>Conclusion</h3> In this large cohort of patients who underwent laparoscopic lymphadenectomy the oncological equivalency and minimal morbidity of this approach was once again demonstrated. With growing experience intraoperative complication rates can be minimised. Teaching and integration of new team members does not impair surgical results when performed under supervision. <h3>Disclosure</h3> Nothing to disclose.
EP855 Metachronous brain metastases in ovarian cancer
2019-11-01

<h3>Introduction/Background</h3> Brain metastasis (BM) from ovarian cancer is a rare disease leading to limited survival. Aim is to evaluate risk factors and survival for BM from epithelial ovarian cancer (EOC). <h3>Methodology</h3> A total of 24 patients diagnosed with metachronous BM after therapy of primary ovarian cancer treated at university Tuebingen from 01/2000 to 3/2019, were retrospectively analyzed. <h3>Results</h3> Age at first diagnosis was 56 years (range 42–71 y) in median; 83,3% had advanced FIGO stages (III/IV); 22 patients had histologic grade 2/3. 46%: node-negative; 46%: node-positive; 8%: Nx. All patients received adjuvant platinum-based chemotherapy ± bevacizumab according to guidelines. At primary surgery, 58.3% achieved complete cytoreduction (R=0 mm), 25.0%: R&gt;0 mm-&lt;1 cm, 4.2%: R≥1 cm, 12.5%: Rx. 12 patients had recurrence of disease. 22 (91,7%) patients had extracranial disease. At diagnosis of BM all patients received whole-brain radiotherapy; 5 obtained additionally neurosurgical intervention. Most common distant metastatic site was lymph nodes, followed by liver, lung and bone. Overall, interval from first diagnosis to occurrence of BM was 39 months in median (range 10–98 months). Overall survival from first diagnosis of ovarian cancer was 46 months in median (range 13–108 months) and after diagnosis of BM was 10 months (range 1–84 months). After complete cytoreduction interval to BM was 46.9 months (range 11–98) in median, after R&gt;0 mm BM were detected after 30 months in median (range 10–52). In women without extracranial disease, interval from first diagnosis to BM was 31.5 months in median (range 14–49), in women with extracranial disease this timespan was 39,7 months median (range 10–98). 17 women with extracranial metastases died of disease. <h3>Conclusion</h3> Despite presenting a rare manifestation of ovarian cancer, development of BM should be considered in advanced ovarian cancer. Presence of extracranial disease was associated with poor survival in patients with BM and leads to longer interval to occurrence of BM. <h3>Disclosure</h3> All authors declare that there is no potential conflict of interest.
Track based alignment procedure for the CBM silicon tracking detector
2019-11-01

Abstract The CBM (Compressed Baryonic Matter) experiment at FAIR is being designed for the study of the QCD phase diagram in the region of the high baryon chemical potential at relatively moderate temperatures. The Silicon Tracking System (STS) is the central detector for momentum reconstruction of the produced charged particles in the CBM experiment. It consists of 8 layers of altogether ∼ 900 double sided silicon micro strip sensors. Limited mechanical precision(&gt; 100 μ m) during the mounting, temperature differences during the experiment, influence of the applied magnetic field result in misalignment to the detector component positions. Therefore, the intrinsic spatial resolution(∼ 20 μ m) of the detector components has to be recovered by a track based alignment method. In this conference paper, the current status of implementation of the alignment algorithm is presented. For this work, the GBL (General broken line) track refit model is employed to create the necessary input data structure to provide the input to the standalone PEDE part of the χ 2 minimization based MILLEPEDE II alignment algorithm.
Heterogeneity of Microscopic Congested Traffic Data Based on Drone Measurements
2019-11-01

We study vehicle trajectories at the onset and existence of traffic congestion and reveal its microscopic features on separate highway lanes. Drone observations of microscopic data of moving vehicles have been made available on three-lane road segments of German highways. Based on these detailed empirical traffic data we reveal heterogeneity and complexity of congested traffic and discuss its consequences. E.g., to perform a safe and comfortable driving behavior by driver assistance systems or automated vehicles lane-level traffic states should be adapted. A congested and dense traffic state only on the left lane of a three-lane highway could be a serious danger. Moreover, we propose an empirical method to calculate local traffic densities that could be used to warn vehicles in advance about high preceding densities. We leverage that concept to study a local traffic jam and discuss its lane-level properties. We reveal the heterogeneity of high local density structures on separate highway lanes.
EP416 Large conization: an effective surgical approach for fertility preservation in young women with early stage cervical cancer
2019-11-01

<h3>Introduction/Background</h3> The shorter cervical segment after radical trachelectomy (RT) imposes a number of pregnancy-associated risk factors. Large conization (LC) can therefore be an oncologically safe alternative to RT in young women with early stage cervical cancer who want to keep their fertility. Our aim was to evaluate fertility-sparing surgical treatment of early-stage cervical cancer after the introduction of LC. Our objectives were to assess surgical, oncological, fertility, and obstetric outcomes. <h3>Methodology</h3> We followed up the oncological and fertility outcomes of patients who underwent LC in a large oncological single University center between 2009 and 2014. Medical records were reviewed and analyzed for surgical, oncological, fertility, and obstetric outcomes. Postal questionnaires were collected to further evaluate and validate the fertility and obstetric outcomes. <h3>Results</h3> A total of 24 LC's were analyzed. Eight patients had to undergo secondary radical hysterectomy after the LC because of non in sano resection. Nine of 16 women tried to conceive, of which all nine became pregnant. Seven mothers gave birth to nine children; The majority of women conceived spontaneously. <h3>Conclusion</h3> Early-stage cervical cancers treated by LC are associated with acceptable oncological outcomes. LC appears to be a safe option for eligible women who intend to maintain their wish for a future pregnancy. <h3>Disclosure</h3> Nothing to disclose.
EP1003 Meigs’ syndrome with elevated serum CA125: case report and review of the literature
2019-11-01

<h3>Introduction/Background</h3> The ovarian cancer represents the seventh most common cancer in women worldwide. An elevated serum CA 125 level in association with a pelvic mass, pleural effusion, and massive ascites usually signifies a dismal prognosis in a postmenopausal woman. Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and pleural effusion. <h3>Methodology</h3> Surgery and histopathological examination are required for the correct diagnosis and treatment. The patient underwent a laparotomy with bilateral salpingo-oophorectomy. All cases of Meigs' syndrome with elevated CA 125 that have been reported were included at this review. <h3>Results</h3> Meigs' syndrome with marked elevated CA 125 is a rare clinical entity and only 47 cases have been reported. An elevated CA 125 level can be falsely positive for ovarian malignancy because the quantity of ascites might be correlated with a rise in the level of CA 125. <h3>Conclusion</h3> Postmenopausal women with a pelvic mass, pleural effusion, ascites and elevated serum CA 125 levels probably suffer from malignant ovarian tumors. However, it is important to remember that these findings does not always predict a lethal condition, but a benign adnexal lesion as part of Meigs' syndrome, should be also considered as an unusual but existing diagnostic possibility. <h3>Disclosure</h3> Nothing to disclose.
P193 p53 and p16 expression profiles identify three prognostically subgroups in vulvar cancer: a TMA based study by the AGO-CaRE-translational study group
2019-11-01

<h3>Introduction/Background</h3> Today, there are two accepted pathways for tumorigenesis of vulvar squamous cell carcinoma (VSCC): an HPV-dependent with p16 overexpression as a surrogate for HPV-associated transformation and an HPV-independent route linked to lichen sclerosus, characterized by p53 mutation. A possible correlation of HPV dependency with a favourable prognosis has been proposed. <h3>Methodology</h3> The AGO CaRE-1 study is a retrospective survey of pts with primary VSCC FIGO stage ≥1B (UICC-TNM version 6) treated at 29 gynecologic cancer centers in Germany 1998–2008 (n=1,618). For this CaRE-translational sub-study available FFPE tissue was collected centrally (n=648). A tissue micro array (TMA) was constructed; p16 and p53 expression was determined by immunohistochemistry (IHC). HPV status and subtype were analyzed by PCR. <h3>Results</h3> p16 IHC was interpretable in 550 TMA spots and considered positive in 166/550 (30.2%). HPV DNA was detected in 78.4% of the p16+ tumors, with HPV 16 being the most common subtype (88.3%). p53 IHC was interpretable in 597 spots, 187/597 (31.3%) were considered positive. Pts with p53+ tumors were older at first diagnosis (71 vs. 66 yrs; p=0.001 for p53- tumors) and showed lymph-node involvement more often (43.3% vs. 31.1%; p=0.007). There was a relevant number of tumors with neither p16 nor p53 overexpression (221/535); while co-expression of p53 and p16 was rare (12/535). For survival analyses, three groups were defined: p53+ (n=163), p16+/p53- (n=151) and p16-/p53- (n=221). 2-y-disease-free (DFS) and overall survival (OS) rates were significantly different between the groups: DFS: p53+ 47.0%; p16-/p53- 53% and p16+/p53- 65.5% (p&lt;0.001); OS: 70.4%, 72.6% and 82.7% (p=0.003), respectively. Adjustment for age and nodal status showed consistent p16 and p53 effects regarding DFS. <h3>Conclusion</h3> p16 overexpression is associated with an improved prognosis in VSCC while p53 positivity is linked to an adverse outcome. Our data provide evidence of a clinically. <h3>Disclosure</h3> The AGO CaRE translational study was supported by medac oncology without restrictions in the study protocol.
Book Reviews
2019-11-01

It is the year 2019 and we now live in the present of the cataclysmic event credited for first introducing the world beyond Japan to anime. I am of course talking about Akira (1988), the seminal feature-length animated film, which, as the author of one of the books reviewed here puts it, took its contemporary audiences by wonder and surprise. In a way, then, what was once part of a distant and imaginary future has somehow already become our present. And while now effectively caught up with this post-apocalyptic fantasy, there still appears to be an ongoing and unresolved battle about whether anime can be taken and discussed seriously. Scholarship is still striving to come to terms with what anime is or could be used for. Interpreting Anime by Christopher Bolton and The Anime Ecology by Thomas Lamarre aim to advance the subfield and surpass previous work; despite differences in purpose and scope, both treat anime seriously and often playfully too. Inasmuch as these efforts come from the two editors of the long-running Mechademia series (since 2006 also published by University of Minnesota Press, arguably the pioneer in the field of anime studies), the establishment of authority is also at stake here. Arguably, contrasting these two major contributions to anime scholarship will help elucidate their respective ambitions and achievements, insights and blind spots.
Controlled Heterotypic Pseudo-Islet Assembly of Human β-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation
2019-11-02

β-Cell functionality and survival are highly dependent on the cells' microenvironment and cell-cell interactions. Since the pancreas is a highly vascularized organ, the crosstalk between β-cells and endothelial cells (ECs) is vital to ensure proper function. To understand the interaction of pancreatic β-cells with vascular ECs, we sought to investigate the impact of the spatial distribution on the interaction of human cell line-based β-cells (EndoC-βH3) and human umbilical vein endothelial cells (HUVECs). We focused on the evaluation of three major spatial distributions, which can be found within human islets <i>in vivo</i>, in tissue-engineered heterotypic cell spheroids, so-called pseudo-islets, by controlling the aggregation process using magnetic levitation. We report that heterotypic spheroids formed by spontaneous aggregation cannot be maintained in culture due to HUVEC disassembly over time. In contrast, magnetic levitation allows the formation of stable heterotypic spheroids with defined spatial distribution and significantly facilitated HUVEC integration. To the best of our knowledge, this is the first study that introduces a human-only cell line-based <i>in vitro</i> test system composed of a coculture of β-cells and ECs with a successful stimulation of β-cell secretory function monitored by a glucose-stimulated insulin secretion assays. In addition, we systematically investigate the impact of the spatial distribution on cocultures of human β-cells and ECs, showing that the architecture of pseudo-islets significantly affects β-cell functionality. Impact statement Tissue engineering of coculture systems containing β-cells and endothelial cells (ECs) is a promising technique to stimulate β-cell functionality. In this study, we analyzed human pancreatic islet tissue and revealed three different native distributions of β-cells and ECs. We successfully recreated these distributions <i>in vitro</i> by employing magnetic levitation of human β-cells and ECs, forming controlled heterotypic pseudo-islets, which enabled us to identify a significant impact of the pseudo-islet architecture on insulin secretion.