julilili42/papers huggingface dataset:
Case Report: Posterolateral Epidural Supra-C2-Root Approach (PESCA) for Biopsy of a Retro-Odontoid Lesions in Same Sitting After Occipitocervical Fixation and Decompression in a Case of Crowned Dens Syndrome With Brainstem Compression and Displacement
2022-04-26

Background ‘Crowned dens syndrome' (CDS) is a special form of calcium pyrophosphate dihydrate deposition disease which is characterized radiologically by a halo-like or crown-like distribution in the periodontoid region and clinically by cervical pain. Herein, we will describe our experience of posterolateral epidural supra-C2-root approach (PESCA) for biopsy of retro-odontoid lesions in one surgical session after occipitocervical fixation and decompression in a patient with CDS and massive brainstem compression. Case Presentation A 70-year-old woman presented to our department with a 4-week history of progressive walking impairment, neck pain, neck rigidity, fever, dizziness, slight palsy of the left hand, and multiple fall episodes. Magnetic resonance imaging (MRI) of the craniovertebral junction (CVJ) and cervical spine revealed a lesion of the odontoid process and the retro-odontoid region with mainly solid components, as well as small cystic components, and brainstem compression and displacement. In first step, fusion surgery of the CVJ C0–C4 was performed with occiptocervical decompression. After fusion and decompression the lower lateral part of the C1 arc and the lateral superior part of the left side of the C2 arc were removed. The entry point was located directly above the superior part of the C2 root. A biopsy of the lateral portions of the lesions was obtained by bioptic forceps under microscope guidance. Pathologic examination of the mass revealed deposition of birefringent crystals compatible with calcium pyrophosphate. In addition to the clinical symptoms (especially neck pain), the diagnosis of CDS was made. Non-steroidal inflammatory drugs (NSAIDs) and colchicine (and later magnesium) were started. At follow-up examination 6 months after surgery, an MRI scan of the cervical spine revealed regression of the pannus and the cyst with replacement of the brainstem, clinical improvement of walking, and increased strength of the left hand. Conclusions This study demonstrates that PESCA can be used to obtain tissue for pathological analysis in one surgical sitting after fusion and decompression and that fusion, decompression, and PESCA (in the same session) together with subsequent conservative management could be a good alternative for the treatment of CDS.
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based Brain Shuttle construct
2022-04-26

<title>Abstract</title> Biallelic mutations in GBA1 that lead to reduced β-glucocerebrosidase (GCase) activity result in the monogenic lysosomal storage disease Gaucher disease (GD). Variants in one GBA1 allele are the most common genetic risk factor for multiple synucleinopathies including Parkinson’s disease (PD). Therapies to increase GCase activity in the brain hold great promise for the treatment of these diseases. To this end, we have developed blood-brain barrier penetrant therapeutic molecules by fusing antibody moieties that bind the transferrin receptor (TfR) to murine or human GCase (referred to as mGCase-mBS or hGCase-hBS, respectively). We demonstrate that these fusion proteins maintain full enzymatic activity and, while their total cellular uptake is only marginally increased compared to the enzyme alone, they have up to 100-fold better lysosomal uptake and function. Uptake and efficacy of GCase-BS relies primarily on binding to the TfR, rather than to mannose phosphate receptors (M6PRs) as conventional enzyme replacement therapy. In a GD cellular model, GCase-BS rapidly rescues the lysosomal proteome and lipid accumulations beyond known GCase substrates. Intravenous injection of mGCase-mBS leads to significant reduction of brain lysosomal membrane lipids in a GD mouse model which is sustained for four weeks. Monthly dosing over six months shows sustained efficacy and reduces neurofilament-light chain (NFL) plasma levels. Collectively, these findings demonstrate the great potential of TfR-targeted GCase for treating GBA1-associated neurodegeneration, provide insight into candidate biomarkers of GD lysosomal dysfunction, and ultimately may open a new treatment paradigm for lysosomal storage diseases (LSDs) extending beyond the central nervous system (CNS).
MapOSR - A Mapping Review Dataset of Empirical Studies on Open Science
2022-04-26

Research that investigates respective researchers’ engagement in Open Science varies widely in the topics addressed, methods employed, and disciplines investigated, which makes it difficult to integrate and compare its results. To investigate current outcomes of Open Science research, and to get a better understanding on topicswell-researched and on research gaps we aim at providing an openly accessible overview of empirical studies that focus on different aspects of Open Science in different scientific disciplines, academic groups and geographical regions. The present data set of studies about Open Science practices was retrieved following a PRISM approach to compile a literature review. We include studies from the Scopus and Web of Science databases with keywords relating to Open Science between the years 2000 and 2020, as well as a snowball search for relevant articles. Studies that did not investigate any aspect of Open Science, or weren’t peer reviewed were excluded, resulting in a total of 695 remaining studies. The data set was collaboratively annotated to ensure intercoder reliability of the coded data.
The Relationality of Ecological Emotions: An Interdisciplinary Critique of Individual Resilience as Psychology’s Response to the Climate Crisis
2022-04-27

An increasing number of academic papers, newspaper articles, and other media representations from all over the world recently bring climate change’s impact on mental health into focus. Commonly summarized under the terms of climate or ecological emotions, these reports talk about distress, anxiety, trauma, grief, or depression in relation to environmental decline and anticipated climate crisis. While the majority of psychology and mental health literature thus far presents preliminary conceptual analysis and calls for empirical research, some explanations of ecological emotions are already offered. They mainly draw from psychoanalysis and depth existential and humanistic psychology, as well as social psychology and address the relationship between ecological emotions and individual engagement in climate action. While these studies suggest building on individual resilience if concerned by ecological emotions, we argue that this only addresses their acute symptoms and not the (chronic) social causes. Based upon our literature research, we show that in an individualistic society such as the (neo-)liberal ones, feelings of individual responsibility are fostered, and this also applies to climate activism.
Intrusion and extrusion of liquids in highly confining media: bridging fundamental research to applications
2022-04-27

Wetting and drying of pores or cavities, made by walls that attract or repel the liquid, is a ubiquitous process in nature and has many technological applications including, for example, liquid separation, chromatography, energy damping, conversion, and storage. Understanding under which conditions intrusion/extrusion takes place and how to control/tune them by chemical or physical means are currently among the main questions in the field. Historically, the theory to model intrusion/extrusion was based on the mechanics of fluids. However, the discovery of the existence of metastable states, where systems are kinetically trapped in the intruded or extruded configuration, fostered the research based on modern statistical mechanics concepts and more accurate models of the liquid, vapor, and gas phases beyond the simplest sharp interface representation. In parallel, inspired by the growing number of technological applications of intrusion/extrusion, experimental research blossomed considering systems with complex chemistry and pore topology, possessing flexible frameworks, and presenting unusual properties, such as negative volumetric compressibility. In this article, we review recent theoretical and experimental progresses, presenting it in the context of unifying framework. We illustrate also emerging technological applications of intrusion/extrusion and discuss challenges ahead.
A novel smartphone app to change risk behaviors of women after gestational diabetes: A randomized controlled trial
2022-04-27

Aims Women after gestational diabetes mellitus (GDM) are a risk group for cardiometabolic diseases but are hard to reach by conventional lifestyle programs. Therefore, we tested whether a novel, smartphone-delivered intervention, TRIANGLE , is accepted by women after GDM and alters cardiometabolic risk behaviors and outcomes. TRIANGLE targets gradual habit change of mind and emotion, physical activity, nutrition, and sleep. Methods We conducted a 6-month multicenter, randomized-controlled trial of TRIANGLE versus standard care with 66 women 3–18 months after GDM in Germany. The primary outcome was the proportion of women achieving ≥3 out of 5 Diabetes Prevention Program goals, i.e. physical activity ≥150 min/week (moderate to high intensity), fiber intake ≥15 g/1,000 kcal, fat intake &lt;30% of total energy intake, saturated fat intake &lt;10% of total energy intake, and weight reduction ≥5% if BMI ≥23 kg/m 2 or weight maintenance if BMI &lt;23 kg/m 2 . Intervention participants also rated the TRIANGLE app in the Mobile Application Rating Scale (uMARS). Results In the predefined, modified intention-to-treat analysis including 64 women, 6 out of 27 women in the intervention group [22%(10–40)] and 3 out of 27 women in the control group [11%(3–27)] reached the primary outcome (p = 0.47). In the predefined per-protocol intervention subgroup, the proportion was 4 out of 14 women [29%(11–55); p = 0.20 vs. control]. TRIANGLE app users were active on 42% of days and rated the app’s quality and perceived impact with 4.3±0.8 out of 5 uMARS points. Conclusions This first trial did not show the efficacy of the TRIANGLE intervention. However, the app was well accepted and considered helpful by most users. Therefore, this trial supports further development and testing of TRIANGLE and other app interventions for women after GDM. Additionally, it identifies necessary adaptations in trial design to better accommodate non-intensive lifestyle interventions for this target group. Trial registration Trial registration at drks.de ( DRKS00012996 ).
Automated Bot Detection Using Bayesian Latent Class Models in Online Surveys
2022-04-27

Behavioral scientists have become increasingly reliant on online survey platforms such as Amazon's Mechanical Turk (Mturk). These platforms have many advantages, for example it provides ease of access to difficult to sample populations, a large pool of participants, and an easy to use implementation. A major drawback is the existence of bots that are used to complete online surveys for financial gain. These bots contaminate data and need to be identified in order to draw valid conclusions from data obtained with these platforms. In this article, we will provide a Bayesian latent class joint modeling approach that can be routinely applied to identify bots and simultaneously estimate a model of interest. This method can be used to separate the bots' response patterns from real human responses that were provided in line with the item content. The model has the advantage that it is very flexible and is based on plausible assumptions that are met in most empirical settings. We will provide a simulation study that investigates the performance of the model under several relevant scenarios including sample size, proportion of bots, and model complexity. We will show that ignoring bots will lead to severe parameter bias whereas the Bayesian latent class model results in unbiased estimates and thus controls this source of bias. We will illustrate the model and its capabilities with data from an empirical political ideation survey with known bots. We will discuss the implications of the findings with regard to future data collection via online platforms.
Genetic Variant ABCC1 rs45511401 Is Associated with Increased Response to Statins in Patients with Familial Hypercholesterolemia
2022-04-27

Statins are the first-line treatment for familial hypercholesterolemia (FH), but response is highly variable due to genetic and nongenetic factors. Here, we explored the association between response and genetic variability in 114 Brazilian adult FH patients. Specifically, a panel of 84 genes was analyzed by exon-targeted gene sequencing (ETGS), and the functional impact of variants in pharmacokinetic (PK) genes was assessed using an array of functionality prediction methods. Low-density lipoprotein cholesterol (LDL-c) response to statins (reduction ≥ 50%) and statin-related adverse event (SRAE) risk were assessed in carriers of deleterious variants in PK-related genes using multivariate linear regression analyses. Fifty-eight (50.8%) FH patients responded to statins, and 24 (21.0%) had SRAE. Results of the multivariate regression analysis revealed that ABCC1 rs45511401 significantly increased LDL-c reduction after statin treatment (p &lt; 0.05). In silico analysis of the amino-acid change using molecular docking showed that ABCC1 rs45511401 possibly impairs statin efflux. Deleterious variants in PK genes were not associated with an increased risk of SRAE. In conclusion, the deleterious variant ABCC1 rs45511401 enhanced LDL-c response in Brazilian FH patients. As such, this variant might be a promising candidate for the individualization of statin therapy.
Gender disparity regarding work-life balance satisfaction among German neuro-oncologists: a YoungNOA survey
2022-04-27

Satisfaction with work-life balance (WLB) is an essential factor for persistent motivation of early career researchers. WLB satisfaction was strongly related to planned reduction in practice times among US medical oncologists.1 The neuro-oncological landscape, however, is sparsely characterized in this regard. We present the results of an interdisciplinary anonymous survey focusing on WLB among neuro-oncologists in Germany which are members of the Neuro-oncology Working Group “Neuroonkologische Arbeitsgemeinschaft” (NOA) of the German Cancer Society (Deutsche Krebsgesellschaft, DKG) (https://www.neuroonkologie.de/). The questionnaire sent to 351 physicians covered personal information and questions aimed to reveal individual motivations, scientific interests and activities as well as individual workload and job satisfaction. The survey was online from 18 March 2021 to 1 April 2021. Ninety-six physicians (36 female, 60 male, Figure 1a) participated in this survey. Most participants were neurosurgeons (42.7%) or neurologists (39.6%, Figure 1b). Furthermore, most participants were university hospital (80.0%, Figure 1c) attending (38.5%, Figure 1d) physicians.
Analytical performance of 17 commercially available point-of-care tests for CRP to support patient management at lower levels of the health system
2022-04-27

Abstract Accurate and precise point-of-care (POC) testing for C-reactive protein (CRP) can help support healthcare providers in the clinical management of patients. Here, we compared the analytical performance of 17 commercially available POC CRP tests to enable more decentralized use of the tool. The following CRP tests were evaluated. Eight quantitative tests: QuikRead go (Aidian), INCLIX (Sugentech), Spinit (Biosurfit), LS4000 (Lansionbio), GS 1200 (Gensure Biotech), Standard F200 (SD Biosensor), Epithod 616 (DxGen), IFP-3000 (Xincheng Biological); and nine semi-quantitative tests: Actim CRP (ACTIM), NADAL Dipstick (nal von minden), NADAL cassette (nal von minden), ALLTEST Dipstick (Hangzhou Alltest Biotech), ALLTEST Cassette cut-off 10-40-80 (Hangzhou Alltest Biotech), ALLTEST Cassette cut-off 10-30 (Hangzhou Alltest Biotech), Biotest (Hangzhou Biotest Biotech), BTNX Quad Line (BTNX), BTNX Tri Line (BTNX). Stored samples (n=660) had previously been tested for CRP using Cobas 8000 Modular analyzer (Roche Diagnostics International AG, Rotkreuz, Switzerland (reference standards). CRP values represented the clinically relevant range (10-100 mg/L) and were grouped into four categories (&lt;10 mg/L, 10–40 mg/L or 10-30 mg/L, 40–80 mg/L or 30-80 mg/L, and &gt; 80mg/L) for majority of the semi-quantitative tests. Among the eight quantitative POC tests evaluated, QuikRead go and Spinit exhibited better agreement with the reference method, showing slopes of 0.963 and 0.921, respectively. Semi-quantitative tests with the four categories showed a poor percentage agreement for the intermediate categories and higher percentage agreement for the lower and upper limit categories. Analytical performance varied considerably for the semi-quantitative tests, especially among the different categories of CRP values. Our findings suggest that quantitative tests might represent the best choice for a variety of use cases, as they can be used across a broad range of CRP categories.
Seasonal phytoplankton and geochemical shifts in the subsurface chlorophyll maximum layer of a dimictic ferruginous lake
2022-04-27

Subsurface chlorophyll maxima layers (SCML) are ubiquitous features of stratified aquatic systems. Availability of the micronutrient iron is known to influence marine SCML, but iron has not been explored in detail as a factor in the development of freshwater SCML. This study investigates the relationship between dissolved iron and the SCML within the dimictic, ferruginous lake Grosses Heiliges Meer in northern Germany. The occurrence of the SCML under non-ferruginous conditions in the spring and ferruginous conditions in the fall are context to explore temporal changes in the phytoplankton community and indicators of primary productivity. Results indicate that despite more abundant chlorophyll in the spring, the SCML sits below a likely primary productivity maximum within the epilimnion, inferred based on co-located dissolved oxygen, δ13CDIC, and pH maxima. The peak amount of chlorophyll in the SCML is lower in the fall than in the spring, but in the fall the SCML is co-located with elevated dissolved iron concentrations and a local δ13CDIC maximum. Cyanobacteria and Chlorophyta have elevated abundances within the SCML in the fall. Further investigation of the relationship of iron to primary productivity within ferruginous SCML may help to understand the environmental controls on primary productivity in past ferruginous oceans.
Tau and neurofilament light‐chain as fluid biomarkers in spinocerebellar ataxia type 3
2022-04-28

Abstract Background and purpose Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures. Methods To evaluate total tau (t‐tau), glial fibrillary acidic protein (GFAP), ubiquitin carboxy‐terminal hydrolase L1 (UCHL1) and neurofilament light‐chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers ( n = 143) and controls ( n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD‐1 platform. Eleven ATXN3 mutation carrier cerebrospinal fluid samples were analysed for t‐tau and phosphorylated tau (p‐tau 181 ). A transgenic SCA3 mouse model (MJDTg) was used to measure cerebellar t‐tau levels. Results Plasma t‐tau levels were higher in mutation carriers below the age of 50 compared to controls, and the Inventory of Non‐Ataxia Signs was associated with t‐tau in ataxic patients ( p = 0.004). Pre‐ataxic carriers showed higher cerebrospinal fluid t‐tau and p‐tau 181 concentrations compared to ataxic patients ( p = 0.025 and p = 0.014, respectively). Cerebellar t‐tau was elevated in MJDTg mice compared to wild‐type ( p = 0.033) only in the early stages of the disease. GFAP and UCHL1 did not show higher levels in mutation carriers compared to controls. Plasma NfL concentrations were higher in mutation carriers compared to controls, and differences were greater for younger carriers. The Scale for the Assessment and Rating of Ataxia was the strongest predictor of NfL in ataxic patients ( p &lt; 0.001). Conclusion Our results suggest that tau might be a marker of early disease stages in SCA3. NfL can discriminate mutation carriers from controls and is associated with different clinical variables. Longitudinal studies are required to confirm their potential role as biomarkers in clinical trials.
Effect of Marble Waste Powder as a Binder Replacement on the Mechanical Resistance of Cement Mortars
2022-04-28

The quarrying of marble and its processing to produce building materials often generates a negative impact on the environment. In the Apuan Alps marble district, a renowned quarrying area in Italy since ancient times, the aquatic pollution of water bodies, caused by the presence of marble waste in the form of powder or sludge, represents a significant and current environmental problem. Depending on the different national and international regulations on waste management, the marble waste can be classified as a special non-hazardous industrial waste. If marble waste has been managed according to environmental international and national laws, it can be reused as a by-product. For this, the present work aims to evaluate the reuse of marble waste as a material in replacement for cement for producing mortars. Subsequently, the mechanical and physical tests were carried out to evaluate the specific properties of the obtained materials during and after the curing time. The results showed that replacement of cement into mortars by marble waste always causes a decrease of mechanical properties, with still acceptable values for many applications up to a substitution of less than 25%. From the collected data, the use of marble waste in the production of cement mortars represents an adequate and sustainable destination of this by-product.
RETRACTED: Self‐regulation in preschool: Are executive function and effortful control overlapping constructs?
2022-04-28

Abstract The concepts of executive function (EF) and effortful control (EC) are strikingly similar. EF originate from neurocognitive research and are described as an accumulation of cognitive processes that serve the goal‐oriented self‐regulation (SR) of an individual. EC originates from temperament research and is defined as the efficiency of executive attention, including the ability to inhibit a dominant response, to activate a subdominant response, to proceed in a planned manner and to recognize conflicts or errors. The aim of this article was to examine the association between the constructs of EF and EC at the preschool‐age. Eighty‐eight children (49 female; M ‐age = 3.93 years, SD = .78) were tested with a computerized battery designed to assess EF at 3–6 years of age (EF Touch). Children's parents completed questionnaires assessing EF impairments (BRIEF‐P) and EC (CBQ). Associations between the constructs and their conceptual overlap were analyzed using correlations and confirmatory factor analyses. We found significant correlations between EF and EC measures. A one‐factor confirmatory model fitted the data very well and indicated that EF and EC are indeed overlapping and highly similar constructs. Therefore, our results show that measures of EC and EF have substantial overlap in preschoolers and suggest an integrated model of self‐regulation.