julilili42/papers huggingface dataset:
A family of autoregressive conditional duration models
2001-08-01

This paper develops a family of autoregressive conditional duration (ACD) models that encompasses most specifications in the literature. The nesting relies on a Box-Cox transformation with shape parameter [delta] to the conditional duration process anda possibly asymmetric shocks impact curve. We establish conditions for the existence of higher-order moments, strict stationarity, geometric ergodicity and [beta]-mixing property with exponential decay. We next derive moment recursion relations and the autocovariance function of the power [delta] of the duration process. Finally, we assess the practical usefulness of our family of ACD models using NYSE price duration data on the IBM stock. While the in-sample results warrant the extra flexibility provided either by the Box-Cox transformation or by the asymmetric response to shocks, we find no specification that entails satisfactory out-of-sample performance.
RE: MALIGNANT GERM CELL TUMOR OF THE CONTRALATERAL TESTIS AFTER RADIOTHERAPY FOR TESTICULAR INTRAEPITHELIAL NEOPLASIA
2001-08-01

No AccessJournal of UrologyCLINICAL UROLOGY: Letters to the Editor1 Aug 2001RE: MALIGNANT GERM CELL TUMOR OF THE CONTRALATERAL TESTIS AFTER RADIOTHERAPY FOR TESTICULAR INTRAEPITHELIAL NEOPLASIA Johannes Classen and Klaus-Peter Dieckmann Johannes ClassenJohannes Classen More articles by this author and Klaus-Peter DieckmannKlaus-Peter Dieckmann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66019-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "RE: MALIGNANT GERM CELL TUMOR OF THE CONTRALATERAL TESTIS AFTER RADIOTHERAPY FOR TESTICULAR INTRAEPITHELIAL NEOPLASIA." The Journal of Urology, 166(2), pp. 630–631 References 1 : Value of radiotherapy in interdisciplinary management of testicular germ cell tumors. Urologe A2000; 39: 126. Google Scholar 2 : Carcinoma in situ of the testis: a review of biological and clinical features. Int J Cancer1999; 83: 815. Google Scholar 3 : Interdisciplinary consensus on diagnosis and therapy of testicular tumors. Results of an update conference based on evidence-based medicine. German Testicular Cancer Study Group. Strahlenther Onkol2000; 176: 388. Google Scholar Department of Radiotherapy, University of Tübingen, Hoppe Seyler Strasse 3, Tübingen D-72074, Germany, Department of Urology, Albertinen-Krankenhaus, Suentelstrasse 10a, Hamburg D-22457Germany© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 166Issue 2August 2001Page: 630-631 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.MetricsAuthor Information Johannes Classen More articles by this author Klaus-Peter Dieckmann More articles by this author Expand All Advertisement PDF downloadLoading ...
Transformation in Ostdeutschland: Hat die Arbeitsmarktpolitik den Betroffenen geholfen?
2001-08-01

Abstract In order to smooth the transition from a planned to a market economy, labour market policies were applied to an unprecedented extent in East Germany. This paper analyses the effects of these policies. As it turns out, labour market policies not only were largely unsuccessful; in many cases they were even prejudicial to the unemployed as well as to regular employees.
In-Situ Ion Milling in the Transmission Electron Microscope (TEM) Outlook to a New Preparation Technique
2001-08-01

Abstract Recent developments in transmission electron microscopy put high demands on specimen preparation. in general the imaging quality is not limited by the performance of the microscope but by the quality of the specimen. in order to achieve a spatial resolution of 0.1 nm in HRTEM undamaged samples with a thickness below 10 nm are required. in energy filtering analytical electron microscopy (EFTEM), a constant specimen thickness over large areas and very low contamination is needed. Conventional ion-milling techniques for TEM specimen preparation are essentially blind. Thus, it is left to chance whether the specimen detail of interest is suitable for TEM-imaging (many specimen areas are too thick). Another problem is the reaction of the specimen with the atmosphere during the transfer from the preparation stage to the microscope, which makes it very difficult to obtain the clean specimen surfaces that are needed in analytical EFTEM. Especially in high-resolution electron microscopy and electron holography the formation of amorphous oxidation and contamination layers on otherwise crystalline materials may seriously reduce the quality of high resolution images of the crystal structure.
NEUTRON CHARGE FORM FACTOR AND QUADRUPOLE DEFORMATION OF THE NUCLEON
2001-08-01

A quark model relation between the neutron charge form factor and the N → ∆ charge quadrupole form factor is used to predict the C2/M 1 ratio in the N → ∆ transition from the elastic neutron form factor data.Excellent agreement with the electro-pionproduction data is found, indicating the validity of the suggested relation.The implication of the negative C2/M 1 ratio for the intrinsic deformation of the nucleon is discussed.
Optical Biosensors. Monitoring Studies of Glycopeptide Antibiotic Fermentation Using White Light Interference
2001-08-02

This paper describes the design, characterization, and use of an optical biosensor suited for the process control of biotechnological processes. The detector principle is based on reflectometric interference spectroscopy (RIfS). RIfS enables a label-free, product-specific monitoring, with a future outline for on-line process control. The potential of the RIfS biosensor is exemplified by the qualitative and quantitative monitoring of the microbial production of vancomycin-type glycopeptide antibiotics.
MRI features of primary central nervous system lymphomas at presentation
2001-08-14

Pretreatment MRI examinations of 40 immunologically competent patients with primary CNS lymphoma (PCNSL) were evaluated (24 men, 16 women, median age 63 years). Seventy lesions were found (mean size: 19.9 mm). The number of lesions ranged from one (n = 25) to six (n = 1). The most frequent locations were the cerebral hemispheres (n = 22), the corpus callosum (n = 11), and the basal ganglia (n = 11). Cerebellar manifestations were found in 10 patients. Ocular (n = 2) and medullary cord (n = 1) manifestations were rare. Contrast enhancement was encountered in all lesions. Although 39 patients had lesions adjacent to the CSF space, leptomeningeal spread was only present in five patients. Necrosis was seen in two lesions only. Edema was extensive in 24 patients, moderate in 11 patients, and absent in five patients. Contrast-enhancing lesions in contact with the subarachnoid space and without necrosis are characteristic of PCNSL.
Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease
2001-08-14

Increasing evidence suggests that apoptosis may be the underlying cell death mechanism in the selective loss of dopaminergic neurons in Parkinson's disease. Because the inhibition of caspases provides only partial protection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/1-methyl-4-phenylpyridinium (MPTP/MPP + ) model of Parkinson's disease, we investigated the role of the proapoptotic c-Jun N-terminal kinase (JNK) signaling cascade in SH-SY5Y human neuroblastoma cells in vitro and in mice in vivo . MPTP/MPP + led to the sequential phosphorylation and activation of JNK kinase (MKK4), JNK, and c-Jun, the activation of caspases, and apoptosis. In mice, adenoviral gene transfer of the JNK binding domain of JNK-interacting protein-1 (a scaffold protein and inhibitor of JNK) inhibited this cascade downstream of MKK4 phosphorylation, blocked JNK, c-Jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. Furthermore, the gene transfer resulted in behavioral benefit. Therefore, inhibition of the JNK pathway offers a new treatment strategy for Parkinson's disease that blocks the death signaling pathway upstream of the execution of apoptosis in dopaminergic neurons, providing a therapeutic advantage over the direct inhibition of caspases.
Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin
2001-08-14

Approximately 10% of all familial cases of amyotrophic lateral sclerosis (fALS) are linked to mutations in the SOD1 gene, which encodes the copper/zinc superoxide dismutase (CuZnSOD). Recently, wild‐type CuZnSOD was shown to protect calcineurin, a calcium/calmodulin‐regulated phosphoprotein phosphatase, from inactivation by reactive oxygen species. We asked whether the protective effect of CuZnSOD on calcineurin is affected by mutations associated with fALS. For this, we monitored calcineurin activity in the presence of mutant and wild‐type SOD. We found that the degree of protection against inactivation of calcineurin by different SOD mutants correlates with the severity of the phenotype associated with the different mutations, suggesting a potential role for calcineurin–SOD1 interaction in the etiology of fALS.
ChemInform Abstract: Oxoammonium Resins as Metal‐Free, Highly Reactive, Versatile Polymeric Oxidation Reagents.
2001-08-14

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dual Repression by Fe 2+ -Fur and Mn 2+ -MntR of the mntH Gene, Encoding an NRAMP-Like Mn 2+ Transporter in Escherichia coli
2001-08-15

ABSTRACT The uptake of Mn 2+ , a cofactor for several enzymes in Escherichia coli , is mediated by MntH, a proton-dependent metal transporter, which also recognizes Fe 2+ with lower affinity. MntH belongs to the NRAMP family of eukaryotic Fe 2+ and Mn 2+ transporters. In E. coli strains with chromosomal mntH-lacZ fusions, mntH was partially repressed by both Mn 2+ and Fe 2+ . Inactivation of fur resulted in the loss of Fe 2+ -dependent repression of mntH transcription, demonstrating that Fe 2+ repression depends on the global iron regulator Fur. However, these fur mutants still showed Mn 2+ -dependent repression of mntH . The Mn 2+ -responsive transcriptional regulator of mntH was identified as the gene product of o155 (renamed MntR). mntR mutants were impaired in Mn 2+ but not Fe 2+ repression of mntH transcription. Binding of purified MntR to the mntH operator was manganese dependent. The binding region was localized by DNase I footprinting analysis and covers a nearly perfect palindrome. The Fur binding site, localized within 22 nucleotides of the mntH operator by in vivo operator titration assays, resembles the Fur-box consensus sequence.
Cell cycle-independent expression of theArabidopsiscytokinesis-specific syntaxin KNOLLE results in mistargeting to the plasma membrane and is not sufficient for cytokinesis
2001-08-15

The Arabidopsis KNOLLE gene encodes a cytokinesis-specific syntaxin that localises to the plane of division and mediates cell-plate formation. KNOLLE mRNA and protein expression is tightly regulated during the cell cycle. To explore the significance of this regulation, we expressed KNOLLE protein under the control of two constitutive promoters, the flower-specific AP3 and the cauliflower mosaic virus 35Spromoter. The transgenic plants developed normally, although KNOLLEmRNA and protein accumulated to high levels in non-proliferating cells and protein was incorporated into membranes. Immunolocalisation studies in transgenic seedling roots revealed mistargeting of KNOLLE protein to the plasma membrane in tip-growing root hairs and in expanding root cells, whereas no mislocalisation was observed in proliferating cells. By comparative in situ hybridisation to embryo sections, the 35S promoter yielded, relative to the endogenous KNOLLE promoter, low levels of KNOLLE mRNA accumulation in proliferating cells that were insufficient to rescue cytokinesis-defective knolle mutant embryos. Our results suggest that in wild type, strong expression of KNOLLE protein during M phase is necessary to ensure efficient vesicle fusion during cytokinesis.
On the Penrose Inequality
2001-08-15

The purpose of this Letter is to point out an argument which may ultimately lead to a rigorous proof of the Penrose inequality in the general case. The argument is a variation of Geroch's original proposal for a proof of the positive-energy theorem which was later adapted by Jang and Wald to apply to initial data sets containing apparent horizons. The new input is to dispense with the a priori restriction to an initial data set and to use the four-dimensional structure of spacetime in an essential way.
NO 2 sensitive Au gate metal–oxide–semiconductor capacitors
2001-08-15

Au gate metal-oxide-semiconductor capacitors are sensitive to NO2 in air up to 200 ppm, depending on operating temperature (100 °C to 200 °C), gate thickness (50 to 900 nm), and morphology. In the absence of catalytic properties or lattice diffusivity, a model invoking molecular surface adsorption and grain boundary diffusion is proposed, which quantitatively describes the transient and steady state response of the devices. Sensitivity is given by the arrival of the diffusing species to the gate–dielectric interface, where capacitive coupling of the adsorbed molecules induces work function changes, which shift the flat band voltage positively, opposite that observed for H2 with Pd gates, consistently with an oxidizing, rather than reducing, character.
Metonymy
2001-08-16

The range of phenomena labelled as “metonymy” is so multifarious that it may seem impossible to reduce all these phenomena to a common semantic denominator. In accordance with many traditional and modern accounts in the fields of rhetoric and linguistics, this article reconstructs metonymy as a linguistic effect upon the content of a given form, based on a figure/ground effect along the contiguity relations within a given frame and generated by pragmatic processes. Thanks to these criteria, we are able to demonstrate the internal diversity as well as the fundamental unity of metonymy with respect to numerous aspects of language (innovation and conventionality, paradigmatic and syntagmatic dimension, linguistic subsystems like grammar, lexicon, etc., different levels of conceptual abstraction, concept and referent, speaker and hearer activities, principle of relevance) and to put metonymy in its right place by distinguishing it from linguistic effects based on other conceptual, especially taxonomic, relations and from other contiguity-based effects.
Exchange currents in nucleon electroexcitation
2001-08-16

We calculate the scalar and transverse helicity amplitudes for the electromagnetic excitation of nucleon resonances as a function of the photon four-momentum transfer. The helicity amplitudes are decomposed into electromagnetic multipoles and connected to the transition form factors. The internal N and dynamics is described by a constituent quark model (CQM) Hamiltonian with gluon, pion, and -meson exchange potentials as residual interactions. The N and -resonance wave functions are obtained by solving the Schr\\"odinger equation in a harmonic oscillator basis which contains up to excitation quanta. For the electromagnetic current we include, in addition to the one-body current, two-body exchange currents associated with the quark-quark potentials. Exchange currents provide an effective description of the cloud of pairs, which together with the valence quarks are important degrees of freedom in physical hadrons. We obtain sizable contributions of the two-body exchange currents for nearly all amplitudes. For some observables, e.g., the ratio in the transition, and the transition to the exchange currents provide the most important contribution.
Erich Fromm's Role in the Foundation of the IFPS: Evidence from the Erich Fromm Archives in T bingen
2001-08-16

AbstractFirst the role is discussed that Erich Fromm played in the foundation of the International Federation of Psychoanalytic Societies (IFPS) according to the documents and correspondence kept in the Fromm Archives in Tübingen (Germany). In the second part the perhaps more interesting question is discussed of what personally motivated Fromm to initiate and to establish a federation of psychoanalytic societies outside of the International Psycho-Analytical Association (IPA). Although the reasons and motivations for Fromm's initiative are in the first line historical they nevertheless have some impact on the present. Therefore, in a final section, Fromm's understanding of psychoanalysis is discussed as a challenge for the IPA as well as for the IFPS.
Diva/Boo is a negative regulator of cell death in human glioma cells
2001-08-17

Diva is a novel proapoptotic member of the Bcl‐2 protein family which binds apoptosis activating factor‐1 (APAF‐1). Diva is identical with Boo which was identified as a novel antiapoptotic Bcl‐2 family protein. Here, we report that Diva promotes the cell cycle exit of human glioma cells in response to serum deprivation and inhibits apoptosis of these cells induced by CD95 ligand or chemotherapeutic drugs. In glioma cells, Diva interferes with apoptotic signaling downstream of cytochrome c release, but upstream of caspase activation, consistent with an inhibitory effect on the mitochondrial amplification step involving the apoptosome and APAF‐1.
ChemInform Abstract: Synthesis and Structures of the Gold Cluster [Au16(AsPh3)8Cl6].
2001-08-21

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Commentary: Immune escape versus tumor tolerance: how do tumors evade immune surveillance?
2001-08-27

Despite an increasing understanding of immunological mechanisms it is still not clear how tumors evade immune-surveillance of the host and how tumors interact with the immune-system. In particular, the question whether tumors arise because of an insufficient immune response or whether tumor cells employ active strategies to escape the control of the immune system is still open. Data from a great number of in vitro studies and animal models offer arguments for both the theory of an immune escape as well as that of tumor tolerance. In this article the available results regarding the mechanisms of host-tumor-interaction are discussed with focus on these two contrary hypotheses.
Siderophore Transport in Fungi
2001-08-29

This chapter contains sections titled: Introduction Siderophore Classes and Properties Siderophore Production and Biosynthesis Evolutionary Aspects of Siderophores Siderophore Transporters in Saccharomyces cerevisiae SIT1 Transporter TAF1 Transporter ARN1 Transporter Transporter for Ferrichromes Transporter for Coprogens ENB1 transporter Energetics and Mechanisms FRE Reductases in Siderophore Transport Conclusions
Mechanisms of Bacterial Iron Transport
2001-08-29

This chapter contains sections titled: Introduction Transport of Fe3+-Siderophores Transport of Fe3+-Siderophores Across the Outer Membrane of Gram-negative Bacteria Transport of Fe3+-Siderophores Across the Cytoplasmic Membrane by ABC Transporters Bacterial Use of Fe3+ Contained in Transferrin and Lactoferrin Bacterial Outer Membrane Proteins that Bind Transferrin and Lactoferrin and Transport Fe3+ Transport of Fe3+ Across the Cytoplasmic Membrane Bacterial Use of Heme Bacterial Outer Membrane Transport Proteins for Heme More than one Ton System for Certain Heme Transport Systems Fe2+ Transport Systems Regulation by Iron Iron-dependent Repressors Regulate Iron Transport Systems Regulation by Fe3+ Regulation by Fe3+-siderophores Regulation of Outer Membrane Transport Protein Synthesis by Phase Variation Outlook
Bacterial Zinc Transport
2001-08-29

This chapter contains sections titled: Introduction Exporters of Toxic Zn2+ RND Family of Exporters Cation Diffusion Facilitator P-Type ATPases Export Cd2+ and Zn2+ High-affinity Uptake Systems for Zn2+ are ABC Transporters Binding Protein-dependent Zn2+ Uptake in Gram-positive Bacteria Binding Protein-dependent Zn2+ Uptake in Gram-negative Bacteria Low-affinity Zn2+ Uptake Systems Concluding Remarks
Using the jackknife‐based scoring method for measuring LRP onset effects in factorial designs
2001-09-01

Miller, Patterson, and Ulrich (1998) introduced a jackknife‐based method for measuring the differences between two conditions in the onset latencies of the lateralized readiness potential (LRP). The present paper generalizes such jackknife‐based methods to factorial experiments with any combination of within‐ and between subjects factors. Specifically, we introduce a subsample scoring method to assess potential main and interaction effects on LRP onsets within conventional yet slightly adjusted analyses of variance (ANOVAs) and post hoc comparison procedures.
Molecular and Functional Characterization of Acid-sensing Ion Channel (ASIC) 1b
2001-09-01

Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in neurotransmission in the central nervous system, in pain perception, as well as in mechanotransduction. Six different ASIC subunits have been cloned to date, which are encoded by four genes (ASIC1-ASIC4). Proton-gated currents have been described in isolated neurons from sensory ganglia as well as from central nervous system. However, it is largely unclear which of the cloned ASIC subunits underlie these native proton-gated currents. Recently, a splice variant, ASIC-beta, has been described for ASIC1a. In this variant about one-third of the protein is exchanged at the N terminus. Here we show that ASIC-beta has a longer N terminus than previously reported, extending the sequence divergence between ASIC1a and this new variant (ASIC1b). We investigated in detail kinetic and selectivity properties of ASIC1b in comparison to ASIC1a. Kinetics is similar for ASIC1b and ASIC1a. Ca(2+) permeability of ASIC1a is low, whereas ASIC1b is impermeable to Ca(2+). Currents through ASIC1a resemble currents, which have been described in sensory and central neurons, whereas the significance of ASIC1b remains to be established. Moreover, we show that a pre-transmembrane 1 domain controls the permeability to divalent cations in ASIC1, contributing to our understanding of the pore structure of these channels.
Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3in Vivo
2001-09-01

Histone deacetylases (HDACs) are part of transcriptional corepressor complexes and play key roles in regulating chromatin structure. Three different classes of human HDACs have been defined based on their homology to HDACs found in Saccharomyces cerevisiae: RPD3 (class I), HDA1 (class II), and SIR2 (class III). Here we describe the identification and functional characterization of HDAC7, a new member of the human class II HDAC family. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleocytoplasmic shuttling. The HDAC activity of HDAC7 maps to a carboxyl-terminal domain and is dependent on the interaction with the class I HDAC, HDAC3, in the cell nucleus. Cytoplasmic HDAC7 that is not bound to HDAC3 is enzymatically inactive. We provide evidence that the transcriptional corepressors SMRT and N-CoR could serve as critical mediators of HDAC7 activity by binding class II HDACs and HDAC3 by two distinct repressor domains. Different class II HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity, but the enzymatic activities associated with HDAC7 and HDAC4 rely on shared cofactors, including HDAC3 and SMRT/N-CoR.