julilili42/papers huggingface dataset:
Visual Occlusions Result in Phase Synchrony Within Multiple Brain Regions Involved in Sensory Processing and Balance Control
2023-01-01

There is a need to develop appropriate balance training interventions to minimize the risk of falls. Recently, we found that intermittent visual occlusions can substantially improve the effectiveness and retention of balance beam walking practice (Symeonidou & Ferris, 2022). We sought to determine how the intermittent visual occlusions affect electrocortical activity during beam walking. We hypothesized that areas involved in sensorimotor processing and balance control would demonstrate spectral power changes and inter-trial coherence modulations after loss and restoration of vision. Ten healthy young adults practiced walking on a treadmill-mounted balance beam while wearing high-density EEG and experiencing reoccurring visual occlusions. Results revealed spectral power fluctuations and inter-trial coherence changes in the visual, occipital, temporal, and sensorimotor cortex as well as the posterior parietal cortex and the anterior cingulate. We observed a prolonged alpha increase in the occipital, temporal, sensorimotor, and posterior parietal cortex after the occlusion onset. In contrast, the anterior cingulate showed a strong alpha and theta increase after the occlusion offset. We observed transient phase synchrony in the alpha, theta, and beta bands within the sensory, posterior parietal, and anterior cingulate cortices immediately after occlusion onset and offset. Intermittent visual occlusions induced electrocortical spectral power and inter-trial coherence changes in a wide range of frequencies within cortical areas relevant for multisensory integration and processing as well as balance control. Our training intervention could be implemented in senior and rehabilitation centers, improving the quality of life of elderly and neurologically impaired individuals.
The Applicability of Interprofessional Education for Collaborative People-centered Practice and Care to Health Plans and Workforce Issues: A Thematic Global Case Review
2023-01-01

ABSTRACT Background: This article focuses on a growing, global recognition of the importance of the field of interprofessional education for person-centered collaborative practice (IPECP) expressed through high-level policy and accreditation decisions/actions taking place in 5 countries. Policy decisions are used to motivate strategies related to IPECP that align with national health plans, and workforce issues. Methods: Using a collective of representative stories from around the globe, a grouping of case studies were developed to illustrate different approaches and challenges to IPECP implementation. Results: Institutions from countries of various income levels face many similar challenges in the execution, delivery, and sustainability of IPECP. All programs face issues of financing, of preparing faculty, of developing and organizing curricula, and of bridging between campus and community. Discussion: Policies are being developed that promote a global approach to the inclusion of IPECP in the accreditation and regulation of postsecondary institutions and health service organizations, in keeping with WHO National Health Workforce Accounts. Policies developed promote and demonstrate the benefits of IPECP through remote emergency learning methods. The policies also build national systems for IPECP as an integral part of continuing professional development and lifelong learning. The organization of interprofessional research programs and the increasing publication of their results of such programs will lead to a clearer understanding of the efficacy of the field of IPECP. To ensure sustainability, stakeholders and policymakers should continue to foster policies that facilitate IPECP.
Digital Decarbonization: Design Principles for an Enterprise-wide Emissions Data Architecture
2023-01-01

The need for corporate decarbonization to mitigate climate change is reflected in a growing number of political measures to transparently disclose the environmental impact of corporate activities. Due to increasing reporting obligations, companies must constantly evaluate their own as well as suppliers' products and processes with respect to emissions data. To date, guidelines on how to design a data architecture focusing on the collection, storage, transformation, distribution, and disclosure of emissions data throughout an entire company are still lacking. Working with the design science research paradigm, we develop seven design principles for an enterprise-wide emissions data architecture (EEDA). We develop and iterate these principles by performing a structured literature review and semi-structured interviews. Taking this emission-centric perspective on data architecture, we foster the active engagement for a structured enterprise-wide approach for managing emissions data and coping with the increased demand for emissions reporting.
The Introspective Patient Experience of Mistletoe Therapy in Cancer: A Qualitative Study
2023-01-01

Introduction: The introspective experience of cancer patients using mistletoe therapy has received little scientific interest, although it is crucial for a holistic understanding of this therapy. This study contributes to patient-centered research and treatment by documenting the subjective experiences of individuals undergoing mistletoe therapy. Methods: In this qualitative, explorative study, 20 outpatients with a history of various cancer types were recruited from Arlesheim Hospital (Arlesheim, Switzerland). All patients received subcutaneous mistletoe therapy for at least 2 years (median 7.5 years). Data was collected through 2 semi-structured, in-depth interviews per patient. Qualitative content analysis was applied to examine the data. The individual experience of mistletoe therapy was analyzed in relation to 6 predefined levels of human experience: physical, vital, emotional, mental, spiritual and social. In addition, 3 further aspects, considered as cross-dimensional perspectives, emerged out of the material: warmth, immune strengthening, and general wellbeing. Results: Data analysis revealed considerable heterogeneity among patients’ experiences with mistletoe therapy. The importance of specific aspects became apparent, such as increased vitality to manage daily life, greater emotional and mental stability, warmth as a multidimensional phenomenon, feelings of safety and protection through mistletoe therapy, heightened self-awareness and improved self-care, as well as sensations of spiritual connectedness. Conclusions: Prior to this study it had not been shown that cancer patients using mistletoe therapy do have observations on different levels of experience. These results may lead to a deeper understanding of patients receiving mistletoe therapy, enabling them to be supported in a more holistic way both during mistletoe treatment and on their life path. Further investigations into the effects of mistletoe therapy on the emotional, mental, and spiritual level are warranted.
Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline
2023-01-01

Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. Autologous haematopoietic stem cell transplantation (AHSCT) aims at eliminating a pathogenic immune repertoire through intense short-term immunosuppression that enables subsequent regeneration of a new and healthy immune system to re-establish immune tolerance for a long period of time. A number of mostly open-label, uncontrolled studies conducted over the past 20 years collected about 4000 cases. They uniformly reported high efficacy of AHSCT in controlling MS inflammatory disease activity, more markedly beneficial in relapsing-remitting MS. Immunological studies provided evidence for qualitative immune resetting following AHSCT. These data and improved safety profiles of transplantation procedures spurred interest in using AHSCT as a treatment option for MS. Objective: To develop expert consensus recommendations on AHSCT in Germany and outline a registry study project. Methods: An open call among MS neurologists as well as among experts in stem cell transplantation in Germany started in December 2021 to join a series of virtual meetings. Results: We provide a consensus-based opinion paper authored by 25 experts on the up-to-date optimal use of AHSCT in managing MS based on the Swiss criteria. Current data indicate that patients who are most likely to benefit from AHSCT have relapsing-remitting MS and are young, ambulatory and have high disease activity. Treatment data with AHSCT will be collected within the German REgistry Cohort of autologous haematopoietic stem CeLl trAnsplantation In MS (RECLAIM). Conclusion: Further clinical trials, including registry-based analyses, are urgently needed to better define the patient characteristics, efficacy and safety profile of AHSCT compared with other high-efficacy therapies and to optimally position it as a treatment option in different MS disease stages.
Medical Oncology Education in Europe: Equipping Medical Oncologists to Provide the Best Care for Patients with Cancer
2023-01-01

Background: High-quality, evidence-based, and practice-relevant education is essential to equip medical oncologists to provide high-quality care for patients with cancer. The need for medical oncology education is growing due to a rapid development of new therapies with novel mechanisms of action. Moreover, the number of patients with cancer is increasing with the rising in incidence and improved survival for some cancers. Access to medical oncology education and training opportunities, particularly in research, varies considerably in different countries and regions. Summary: The European Society for Medical Oncology (ESMO), the European School of Oncology (ESO), and other relevant associations have developed a wide range of opportunities, resources, and measures to increase access to high-quality medical oncology education. Initiatives that are helping to achieve effective and consistent medical oncology education include the ESMO/ASCO (American Society of Medical Oncology) global curriculum in medical oncology. Key Messages: There is great value in providing wider educational opportunities than local and national training to increase access and, potentially, quality and scope and reduce variations in medical oncology education. Pan-European and global educational initiatives open up the expertise, knowledge, and best practice on different tumour types and cross-sectional topics, such as supportive and palliative care that can be shared between medical oncologists from other countries.
Hierarchical modelling of microbial communities
2023-01-01

Abstract Summary The human body harbours a plethora of microbes that play a fundamental role in the well-being of the host. Still, the contribution of many microorganisms to human health remains undiscovered. To understand the composition of their communities, the accurate genome-scale metabolic network models of participating microorganisms are integrated to construct a community that mimics the normal bacterial flora of humans. So far, tools for modelling the communities have transformed the community into various optimization problems and model compositions. Therefore, any knockout or modification of each submodel (each species) necessitates the up-to-date creation of the community to incorporate rebuildings. To solve this complexity, we refer to the context of SBML in a hierarchical model composition, wherein each species’s genome-scale metabolic model is imported as a submodel in another model. Hence, the community is a model composed of submodels defined in separate files. We combine all these files upon parsing to a so-called ‘flattened’ model, i.e., a comprehensive and valid SBML file of the entire community that COBRApy can parse for further processing. The hierarchical model facilitates the analysis of the whole community irrespective of any changes in the individual submodels. Availability and implementation The module is freely available at https://github.com/manuelgloeckler/ncmw.
Unfamiliar Contexts Compared to Familiar Contexts Impair Learning in Humans
2023-01-01

Re-exposure to the context that information was learned in facilitates its memory retrieval. However, the influence of context changes on the ability to learn new information is less well understood, which the present work investigated in two experiments with healthy participants (n = 40 per experiment; 20 female). In experiment 1, participants learned a list of word-pairs (A-B) in the morning, after which their memory for the word-pairs was immediately tested. In the evening, they learned and were tested on a second non-overlapping list (C-D), either in the same context or in a different context than the first list (between-subjects). We found that new learning is enhanced in the same context, and that new learning in the other context was decreased compared to baseline. In experiment 2, participants were exposed to both contexts in the morning, but only learned word-pairs in one of them. In the second learning session in the evening, this familiarization with the other context abolished differences between the same and other context group. These data point to context novelty interfering with new learning rather than context familiarity enhancing it. Importantly, the reduction of new learning in the other context in the first experiment, where the context was unfamiliar in both learning sessions, suggests mechanisms beyond attention processes that are bound by the novelty of the other context. Rather, the old context impairs the processing of the new context, possibly by biasing pattern completion and pattern separation trade-offs within the hippocampus.
John Boy Walton at SemEval-2023 Task 5: An Ensemble Approach to Spoiler Classification and Retrieval for Clickbait Spoiling
2023-01-01

Clickbait spoiling is a task of generating or retrieving a fairly short text with a purpose to satisfy curiosity of a content consumer without their addressing to the document linked to a clickbait post or headline. In this paper we introduce an ensemble approach to clickbait spoiling task at SemEval-2023. The tasks consists of spoiler classification and retrieval on Webis-Clickbait-22 dataset. We show that such an ensemble solution is quite successful at classification, whereas it might perform poorly at retrieval with no additional features. In conclusion we outline our thoughts on possible directions to improving the approach and shape a set of suggestions to the said features.
FramingFreaks at SemEval-2023 Task 3: Detecting the Category and the Framing of Texts as Subword Units with Traditional Machine Learning
2023-01-01

This paper describes our participation as team FramingFreaks in the SemEval-2023 task 3 “Category and Framing Predictions in online news in a multi-lingual setup.” We participated in subtasks 1 and 2. Our approach was to classify texts by splitting them into subwords to reduce the feature set size and then using these tokens as input in Support Vector Machine (SVM) or logistic regression classifiers. Our results are similar to the baseline results.
CLAUDIUS Study: Risk of materno-fetal transmission of melanoma cells in pregnant women with high grade melanoma – A retrospective multicenter study and literature review
2023-01-01

Background: Vertical transmission of maternal cancer cells to the child is extremely rare, but melanoma represents the most common culprit. The aim of this study is to determine individual risks for materno-fetal transmission of melanoma cells and to establish standardized procedures for pregnant melanoma patients and their offspring. Patients and methods: In this retrospective multicenter study, data on women with stage III or IV melanoma that had been diagnosed before, during or up to 12 months after pregnancy, were analyzed for the occurrence of metastases in the placenta or the infant. In addition, a literature search for previously described materno-fetal transmission in case of maternal melanoma was conducted. A historical patient group was established from these cases and a statistical analysis was performed (SAS, p < 0.05 significant). Results: In total, 67 children born to women with stage III or IV melanoma were included. No placental or infant metastases were detected in any of the cases. The additional literature search revealed 37 cases with placental metastases and 14 cases with infant metastases (6 of them overlapping). Of the affected children, 10 (71.43%) died from their disease. Maternal death shortly after birth seems to be an unfavorable factor for transmission to the infant. Conclusion: The risk of materno-fetal transmission of maternal melanoma metastases seems to be much lower than anticipated based on former studies. However, thorough placental screening and systematic follow-up of the children resulting from pregnancies of high-risk melanoma patients should be performed.
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue
2023-01-01

Here, we report the development of a mutasynthesis approach for the derivatisation of pristinamycin I based on the phenylglycine residue in combination with a biotransformation process for mutasynthon provision.
Wavelength-aware 2D Convolutions for Hyperspectral Imaging
2023-01-01

Deep Learning could drastically boost the classification accuracy for Hyperspectral Imaging (HSI). Still, the training on the mostly small hyperspectral data sets is not trivial. Two key challenges are the large channel dimension of the recordings and the incompatibility between cameras of different manufacturers.By introducing a suitable model bias and continuously defining the channel dimension, we propose a 2D convolution optimized for these challenges of Hyperspectral Imaging. We evaluate the method based on two different hyperspectral applications (inline inspection and remote sensing). Besides the shown superiority of the model, the modification adds additional explanatory power.In addition, the model learns the necessary camera filters in a data-driven manner. Based on these camera filters, an optimal camera can be designed.
Synthesis and characterisation of four bimetallic gold–gallium clusters with Au–Ga rings as a new structural motif in gold cluster chemistry
2023-01-01

The synthesis and structure of four phosphine-stabilized gold–gallium clusters is presented, showing novel structural motives like a [AuGa] x chain, which is similar to the –SL–(Au–SL–) n staple motifs in thiolate-stabilized gold cluster compounds.
Predictors of sustained use of mobile health applications: Content analysis of user perspectives from a fever management app
2023-01-01

Objectives Mobile health applications could be means of educating and changing behaviours of their users. Their features and qualities determine the sustainability of use. The FeverApp with two main features of information and documentation is a research-based app. In this observational cohort study, to evaluate the influential predictors of use, users’ feedback on the FeverApp, were analyzed. Methods Feedback is given using a structured questionnaire, four Likert items and two open questions regarding positive and negative impressions, available via app menu. Conventional content analysis (inductive approach) on the two open questions was performed. Comments were grouped into 12 codes. These codes were grouped hierarchically in an iterative process into nine subcategories and lastly into two main categories ‘format’ and ‘content’. Descriptive and quantitative analysis were performed. Results Out of 8243 users, 1804 of them answered the feedback questionnaire. The features of the app ( N = 344), followed by the information aspect ( N = 330) were most frequently mentioned. Documentation process ( N = 226), request for new features or improvement of the current ones ( N = 193), and functioning ( N = 132) were also highlighted in users’ feedback. App's ease of use, design and being informative were important for the users. The first impression of the app seems important as the majority of feedback were given during the first month of using the app. Conclusion In-app feedback function could highlight shortcomings and strengths of mobile health apps. Taking users’ feedback into consideration could increase the chance of sustained use. Besides ease of use and clear, likeable designs, users want apps that serve their needs while saving time.
SIGMORPHON 2022 Shared Task on Grapheme-to-Phoneme Conversion Submission Description: Sequence Labelling for G2P
2023-01-01

This paper describes our participation in the Third SIGMORPHON Shared Task on Grapheme-to-Phoneme Conversion (Low-Resource and Cross-Lingual) (McCarthy et al.,2022). Our models rely on different sequence labelling methods. The main model predicts multiple phonemes from each grapheme and is trained using CTC loss (Graves et al., 2006). We find that sequence labelling methods yield worse performance than the baseline when enough data is available, but can still be used when very little data is available. Furthermore, we demonstrate that alignments learned by the sequence labelling models can be easily inspected.
A novel synthetic inhibitor of polyamine utilization in Streptomyces coelicolor
2023-01-01

Abstract In this work, we present the first inhibitor of GlnA2Sc, a gamma-glutamylpolyamine synthetase, which allows Streptomyces coelicolor to detoxify high concentrations of polyamines and to utilize them as a carbon or nitrogen source. GlnA2 belongs to the class of glutamine synthetase-like (GS-like) enzymes that catalyze the glutamylation of different nitrogen-containing compounds. Whereas a number of inhibitors for GS are known, none of them are known to inhibit GlnA2. In this work, PPU268, an inhibitor for GlnA2 is presented that is structurally derived from the prototypic GS inhibitor—methionine sulfoximine (MSO). It combines two features: the binding mechanism of MSO and the amine substrate specificity of GlnA2Sc. This inhibitor is a novel compound to block the polyamine utilization in bacteria resulting in the inability to detoxify polyamines. This may offer a possibility to develop novel therapeutic strategies to combat actinobacterial human pathogens that encounter polyamines in the course of the infection processes.
Detailed intraocular pressure curve by telemetric tonometry with an implanted pressure sensor before and after PreserFlo® MicroShunt implantation: a case report
2023-01-01

Continuous control of intraocular pressure (IOP) is crucial to preventing long-term damage to the optic nerve in glaucoma. Recently, a novel telemetric IOP sensor (EYEMATE-IOTM, Implandata Ophthalmic Products GmbH, Hannover, Germany) has been developed that continuously records IOP. The patient can read the IOP measurements wirelessly using a hand-held reading device. We present the case of a 70-year-old patient with primary open-angle glaucoma who had been implanted with an EYEMATE-IOTM and recently underwent minimally invasive bleb-filtering surgery with the PreserFlo ® MicroShunt (Santen, Osaka, Japan). This case demonstrates both the benefits of continuous pressure measurement with EYEMATE-IOTM and the ability of the PreserFlo ® MicroShunt to significantly reduce IOP fluctuations.