julilili42/papers huggingface dataset:
Rising temperatures reduce global wheat production
2014-12-19

Crop models are essential tools for assessing the threat of climate change to local and global food production. Present models used to predict wheat grain yield are highly uncertain when simulating how crops respond to temperature. Here we systematically tested 30 different wheat crop models of the Agricultural Model Intercomparison and Improvement Project against field experiments in which growing season mean temperatures ranged from 15 °C to 32 °C, including experiments with artificial heating. Many models simulated yields well, but were less accurate at higher temperatures. The model ensemble median was consistently more accurate in simulating the crop temperature response than any single model, regardless of the input information used. Extrapolating the model ensemble temperature response indicates that warming is already slowing yield gains at a majority of wheat-growing locations. Global wheat production is estimated to fall by 6% for each °C of further temperature increase and become more variable over space and time.
Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant
2014-12-19

In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The forebrain knockout mice showed &gt;90% deletion of BMAL1 in the SCN and exhibited an immediate and complete loss of circadian behavior in constant conditions. Circadian rhythms in peripheral tissues persisted but became desynchronized and damped in constant darkness. The loss of synchrony was rescued by light/dark cycles and partially by restricted feeding (only in the liver and kidney but not in the other tissues) in a distinct manner. These results suggest that the forebrain/SCN is essential for internal temporal order of robust circadian programs in peripheral clocks, and that individual peripheral clocks are affected differently by light and feeding in the absence of a functional oscillator in the forebrain.
Toxicity of an α-Pore-forming Toxin Depends on the Assembly Mechanism on the Target Membrane as Revealed by Single Molecule Imaging
2014-12-19

α-Pore-forming toxins (α-PFTs) are ubiquitous defense tools that kill cells by opening pores in the target cell membrane. Despite their relevance in host/pathogen interactions, very little is known about the pore stoichiometry and assembly pathway leading to membrane permeabilization. Equinatoxin II (EqtII) is a model α-PFT from sea anemone that oligomerizes and forms pores in sphingomyelin-containing membranes. Here, we determined the spatiotemporal organization of EqtII in living cells by single molecule imaging. Surprisingly, we found that on the cell surface EqtII did not organize into a unique oligomeric form. Instead, it existed as a mixture of oligomeric species mostly including monomers, dimers, tetramers, and hexamers. Mathematical modeling based on our data supported a new model in which toxin clustering happened in seconds and proceeded via condensation of EqtII dimer units formed upon monomer association. Furthermore, altering the pathway of EqtII assembly strongly affected its toxic activity, which highlights the relevance of the assembly mechanism on toxicity.
Capturing molecules with plasmonic nanotips in microfluidic channels by dielectrophoresis
2014-12-19

A method for the collection and concentration of molecules on arrays of metallic nanocones is presented, making use of the high electric field gradients at the nanotips. The nanocones are integrated into a microfluidic channel and used as nanoelectrodes. By applying an AC voltage, dielectrophoresis is used to capture molecules from the channel region on the nanocones.
Limited access to drugs for resistant tuberculosis: a call to action: Table 1
2014-12-19

Although the rate of new tuberculosis (TB) cases has been falling worldwide, progress toward the targets for diagnosis and treatment of drug-resistant TB is far off-track. In countries with no reliable TB surveillance system, setbacks and progression of TB control is barely reflected and little is known on the situation in the field. Interviews with health professionals in Gabon revealed limited access to first- and second-line TB drugs and important deficiencies in basic TB control. National and international action needs to be taken to meet the global TB control targets.
A universal glue: underwater adhesion of the secretion of the carnivorous flypaper plantRoridula gorgonias
2014-12-19

Glandular trichomes of the carnivorous plant Roridula gorgonias release a viscous resinous secretion. Its adhesion to hydrophilic and hydrophobic glass surfaces was measured in air and underwater. The underwater adhesion reached up to 91% (on hydrophilic glass) and 28% (on hydrophobic glass) of that measured in the air. After being submersed for 24 h in water, trichomes did not lose their ability to adhere to both types of glass surfaces underwater. We assume that acylglycerides and triterpenoids, which have been demonstrated previously to be main compounds of the secretion, cause the predominantly non-polar character and the insolubility in water. The robustness of the secretion to a wet environment presumably enables the plant to maintain its trapping function also under humid conditions and during rainy weather.
TRIASSIC – QUATERNARY SEQUENCE STRATIGRAPHY OF THE TARFAYA BASIN (MOROCCAN ATLANTIC): STRUCTURAL EVOLUTION, EUSTASY AND SEDIMENTATION
2014-12-19

This paper discusses the seismic and sequence stratigraphy of the Tarfaya Basin passive continental margin in southern Morocco and investigates the implications for the basin's petroleum geology. Analyses of a new database consisting of SGY 2D seismic lines and wells indicate that the sedimentary succession on the Tarfaya margin can be divided into ten seismic sequences within four major transgressive‐regressive cycles separated by regional unconformities. Variations in the stratigraphic architecture of the margin suggest that regional tectonic influences have episodically overprinted global eustatic signals. A number of clastic reservoirs and source rock intervals have been identified in this margin, but only Jurassic carbonate and Cretaceous clastic plays have been tested on the shelf area. Cretaceous submarine fans and Tertiary turbidite systems in deep‐water areas remain untested and may have major hydrocarbon potential.
Crystal structure of 5-[bis(methylsulfonyl)methyl]-1,3-dimethyl-5-(methylsulfonyl)pyrimidine-2,4,6(1H,3H,5H)-trione
2014-12-19

In the title compound, C 10 H 16 N 2 O 9 S 3 , the pyrimidine ring of the 1,3-dimethyl barbituric acid moiety has an envelope conformation with the C atom carrying the methylsulfonyl and bis(methylsulfonyl)methyl substituents as the flap. The dihedral angle between mean plane of the pyrimidine ring and the S/C/S plane is 72.4 (3)°. In the crystal, molecules are linked via C—H...O hydrogen bonds, forming a three-dimensional structure.
Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes
2014-12-20

Pro-inflammatory cytokines like interleukin-1 beta (IL-1) are major players in the interaction between the immune system and the central nervous system. Various animal studies report a sleep-promoting effect of IL-1 leading to enhanced slow wave sleep (SWS). Moreover, this cytokine was shown to affect hippocampus-dependent memory. However, the role of IL-1 in human sleep and memory is not yet understood. We administered the synthetic IL-1 receptor antagonist anakinra (IL-1ra) in healthy humans (100mg, subcutaneously, before sleep; n=16) to investigate the role of IL-1 signaling in sleep regulation and sleep-dependent declarative memory consolidation. Inasmuch monocytes have been considered a model for central nervous microglia, we monitored cytokine production in classical and non-classical blood monocytes to gain clues about how central nervous effects of IL-1ra are conveyed. Contrary to our expectation, IL-1ra increased EEG slow wave activity during SWS and non-rapid eye movement (NonREM) sleep, indicating a deepening of sleep, while sleep-associated memory consolidation remained unchanged. Moreover, IL-1ra slightly increased prolactin and reduced cortisol levels during sleep. Production of IL-1 by classical monocytes was diminished after IL-1ra. The discrepancy to findings in animal studies might reflect species differences and underlines the importance of studying cytokine effects in humans.
Host-country effects in coordinated, liberal and hybrid market economies: US subsidiaries in Switzerland, Germany and the UK
2014-12-20

The paper addresses two as yet unexplored issues regarding the uptake of host-country employment relations practices, contributing to a better understanding of findings for hybrid host-market economies such as Switzerland. Host-country effects are differentiated by practices that belong to either industrial relations or education and training, as per the varieties of capitalism approach. There follows an investigation of the extent to which foreign subsidiaries' overall uptake of host-country employment relations practices is determined by the subsidiary incorporation type and size for practices related to industrial relations and education and training. Analyses of US subsidiaries in Switzerland, and, in contrast, those in Germany and the UK, on the whole support the propositions that distinguish between industrial relations and education and training-related host-country effects.
EFFICIENT COMPUTATION OF THE MCTDHF APPROXIMATION TO THE TIME-DEPENDENT SCHRODINGER EQUATION
2014-12-21

Abstract. We discuss analytical and numerical properties of the multi-configuration time-dependent Hartree–Fock method for the approximate so-lution of the time-dependent multi-particle (electronic) Schrödinger equation which are relevant for an efficient implementation of this model reduction tech-nique. Particularly, we focus on a discretization and low rank approximation in the evaluation of the meanfield terms occurring in the MCTDHF equations of motion, which is crucial for the computational tractability of the problem. We give error bounds for this approximation and demonstrate the achieved gain in performance. 1.
Dipeptides catalyze rapid peptide exchange on MHC class I molecules
2014-12-22

Significance We have shown previously that dipeptides can support efficient in vitro folding of the MHC class I molecules. Here, we describe the discovery of dipeptides that catalyze the dissociation of low- and high-affinity peptides from class I and their replacement for exogenous peptides of interest, on both recombinant and cell surface HLA-A*02:01, HLA-B*27:05, and H-2K b molecules. Understanding peptide exchange on class I will help us understand peptide optimization in live cells. We demonstrate that the peptide-exchange technology can be used to produce epitope-specific MHC tetramers much faster and more easily than possible with techniques currently available and to enhance peptide loading onto live cells for cancer immunotherapy. Further applications include allotype specific peptide epitope elution from tumor cells.
What are depressive symptoms in acutely ill patients with schizophrenia spectrum disorder?
2014-12-22

Abstract Background: Aim was to examine depressive symptoms in acutely ill schizophrenia patients on a single symptom basis and to evaluate their relationship with positive, negative and general psychopathological symptoms. Methods: Two hundred and seventy-eight patients suffering from a schizophrenia spectrum disorder were analysed within a naturalistic study by the German Research Network on Schizophrenia. Using the Calgary Depression Scale for Schizophrenia (CDSS) depressive symptoms were examined and the Positive and Negative Syndrome Scale (PANSS) was applied to assess positive, negative and general symptoms. Correlation and factor analyses were calculated to detect the underlying structure and relationship of the patient’s symptoms. Results: The most prevalent depressive symptoms identified were depressed mood (80%), observed depression (62%) and hopelessness (54%). Thirty-nine percent of the patients suffered from depressive symptoms when applying the recommended cut-off of a CDSS total score of &gt; 6 points at admission. Negligible correlations were found between depressive and positive symptoms as well as most PANSS negative and global symptoms despite items on depression, guilt and social withdrawal. The factor analysis revealed that the factor loading with the PANSS negative items accounted for most of the data variance followed by a factor with positive symptoms and three depression-associated factors. Limitations: The naturalistic study design does not allow a sufficient control of study results for the effect of different pharmacological treatments possibly influencing the appearance of depressive symptoms. Conclusion: Results suggest that depressive symptoms measured with the CDSS are a discrete symptom domain with only partial overlap with positive or negative symptoms.
Triggering of Programmed Erythrocyte Death by Alantolactone
2014-12-22

The sesquiterpene alantolactone counteracts malignancy, an effect at least in part due to stimulation of suicidal death or apoptosis of tumor cells. Signaling of alantolactone induced apoptosis involves altered gene expression and mitochondrial depolarization. Erythrocytes lack mitochondria and nuclei but may enter suicidal death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Cellular mechanisms involved in triggering of eryptosis include increase of cytosolic Ca2+-activity ([Ca2+]i) and oxidative stress. The present study explored, whether alantolactone stimulates eryptosis. To this end, erythrocyte volume was estimated from forward scatter, phosphatidylserine-exposure at the erythrocyte surface from FITC-annexin-V-binding, [Ca2+]i from Fluo3-fluorescence, ceramide abundance from binding of fluorescent antibodies, and oxidative stress from 2',7'-dichlorodihydrofluorescein-diacetate (DCFDA) fluorescence. As a result, a 48 h exposure of human erythrocytes to alantolactone (≥20 μM) significantly decreased erythrocyte forward scatter and increased the percentage of annexin-V-binding cells. Alantolactone significantly increased Fluo3 fluorescence (60 μM), ceramide abundance (60 μM) and DCFDA fluorescence (≥40 μM). The effect of alantolactone (60 μM) on annexin-V-binding was not significantly modified by removal of extracellular Ca2+. In conclusion, alantolactone stimulates suicidal erythrocyte death or eryptosis, an effect paralleled by increase of [Ca2+]i, ceramide abundance and oxidative stress.
LINEAR AND PROJECTIVE BOUNDARY OF NILPOTENT GROUPS
2014-12-22

Abstract We define a pseudometric on the set of all unbounded subsets of a metric space. The Kolmogorov quotient of this pseudometric space is a complete metric space. The definition of the pseudometric is guided by the principle that two unbounded subsets have distance 0 whenever they stay sublinearly close. Based on this pseudometric we introduce and study a general concept of boundaries of metric spaces. Such a boundary is the closure of a subset in the Kolmogorov quotient determined by an arbitrarily chosen family of unbounded subsets. Our interest lies in those boundaries which we get by choosing unbounded cyclic sub(semi)groups of a finitely generated group (or more general of a compactly generated, locally compact Hausdorff group). We show that these boundaries are quasi-isometric invariants and determine them in the case of nilpotent groups as a disjoint union of certain spheres (or projective spaces). In addition we apply this concept to vertex-transitive graphs with polynomial growth and to random walks on nilpotent groups.
Prognostic Significance of Dynamic 18F-FET PET in Newly Diagnosed Astrocytic High-Grade Glioma
2014-12-23

Early TTP(min) is associated with worse outcome in patients with newly diagnosed astrocytic HGG. In the preoperative setting, TTP(min) can be a valuable noninvasive prognostic marker with comparable significance to WHO grade. Additionally, TTP(min) can help identify highly aggressive WHO III astrocytoma tumors and may help in adjusting standard treatment toward an individualized, risk-adapted therapy regime.
Comparison of Different Tractography Algorithms and Validation by Intraoperative Stimulation in a Child with a Brain Tumor
2014-12-23

Although, all tractography algorithms successfully identified the core of the corticospinal pathway, deterministic DTI-tractography, as widely used in clinical neuronavigation software, only insufficiently visualized critical fibers here. We believe these results argue for a stronger consideration of advanced tractography approaches in neurosurgical planning.
Lactotransferrin Gene (LTF) Polymorphisms and Dental Implant Loss: A Case‐Control Association Study
2014-12-23

Abstract Background Dental implants have been widely used to replace missing teeth, accomplishing aesthetics and function. Due to its large use worldwide, the small percentage of implant loss becomes significant in number of cases. L actotransferrin ( LTF ) is a pleiotropic protein, expressed in various body tissues and fluids, which modulates the host immune‐inflammatory response and bone metabolism, and might be involved in dental implant osseointegration. Recently, a few studies have been investigating genetic aspects underlying dental implant failure. Purpose This case‐control study aimed to investigate the association of genetic markers (tag SNPs ) in LTF gene and clinical parameters with dental implant loss. Material and Methods 278 patients, both sexes, mean age 51 years old, divided into 184 without and 94 with implant loss, were genotyped for sixteen tag SNPs , representative of the whole LTF gene. Also, clinical oral and systemic parameters were analyzed. U nivariate and M ultivariate L ogistic R egression model were used to analyze the results ( p &lt; .05). Results No association was found between the tag SNPs and implant loss in the study population. Clinical association was found with medical treatment, hormonal reposition, edentulism, number of placed implants, plaque, calculus, and mobility. Conclusion Clinical variables, but not LTF gene polymorphisms, were associated with implant loss.
How can two soft bodied animals be precisely connected? a miniature quick‐connect system in the slugs,Arion lusitanicusandArion rufus
2014-12-23

ABSTRACT Among stylommatophoran gastropods, many species have simplified or reduced their copulatory organs, for example, within the Arionidae, many species lack penes. In this study, I ask two questions 1) How are soft bodied slugs which do not possess a penis connected during copulation? and 2) Is there a mechanical isolating barrier between related sympatric slug species? Observations on the mating behavior and the functional morphology of the distal genital apparatus were made in a mixed population of Arion lusitanicus and Arion rufus . The investigated Arion species exhibit an elaborate copulation process with a quick genital coupling. Prior to full eversion of the distal genitalia, the genital coupling proceeds inside the atrium cavity of one of the partners. This is in contrast to the symmetrical mutual eversion in penis‐bearing species. The donor–recipient channels are tightly connected to one after another and fit precisely. During copulation, the jelly‐coated spermatophore of the donor is pressed out into the connected channel of the partner, where it is implanted only with its frontal part. In the field, successful interspecific matings in terms of spermatophore transfer were rarely observed. The observations presented indicate a mechanical barrier which may profoundly influence the intraspecific and interspecific mating success. J. Morphol. 276:631–648, 2015. © 2014 Wiley Periodicals, Inc.
Effects of an Internet intervention (Deprexis) on severe depression symptoms: Randomized controlled trial
2014-12-24

Background: Studies have shown that certain Internet interventions can help alleviate depression. However, many such interventions contain personal support elements, making it difficult to ascertain whether the program or the support drives the effects. Studies are needed to investigate whether Internet interventions contribute to symptom reduction even when they are delivered without personal support, and even among severely depressed individuals who often receive other forms of treatment. Objective: This randomized controlled trial aimed to examine the effect of an Internet intervention that was deployed without personal support (“Deprexis”) among adults with initially severe depression symptoms. Methods: Adults recruited from a range of sources who had exceeded the threshold for severe depression (PHQ-9 ≥ 15) in a pre-screening assessment and met inclusion criteria were randomized (N = 163) to the intervention (3 months program access; n = 78) or care-as-usual/waitlist control (n = 85). A diagnostic screening interview was administered by telephone at baseline to all participants. Online assessments were administered at baseline, 3 months (post-treatment), and 6 months (follow-up). The main outcome was the Patient Health Questionnaire (PHQ-9) between baseline and post-treatment. Results: Eighty-two percent of randomized participants were reached for the post-treatment assessment. Results for the intention-to-treat (ITT) sample showed significant intervention effects on depression reduction between baseline and post-treatment (linear mixed model [MM], F1,155.6 = 9.00, p < .01, for the time by condition interaction), with a medium between-group effect size, Cohen's d = 0.57 (95% CI: 0.22–0.92). Group differences in depression severity at follow-up were marginally significant in the ITT sample, t (119) = 1.83, p = 0.07, and smaller than at post-treatment (PHQ-9, d = 0.33, 95% CI: −0.03–0.69). The number needed to treat (NNT) at post-treatment was 5, with 38% of participants in the intervention group achieving response (at least 50% PHQ-9 symptom change, plus post-treatment score <10), compared to 17% in the control group, p < 0.01. Effects on secondary outcomes, including anxiety, health-related quality of life, and somatic symptoms, were not significant, with the exception of significant effects on anxiety reduction in PP analyses. Early ratings of program helpfulness/alliance (after 3 weeks) predicted pre–post depression reduction, controlling for baseline severity and early symptom change. Conclusions: These results replicate and extend previous findings by showing that Deprexis can facilitate symptomatic improvement over 3 months and, perhaps to a lesser degree, up until 6 months among adults with initially severe depression.