1271 INFLUENCE OF PATIENT-RELATED FACTORS ON SCREENING RESULTS FOR BLADDER CANCER USING FLUORESCENCE IN SITU HYBRIDIZATION
2012-04-01

You have accessJournal of UrologyBladder Cancer: Detection and Screening1 Apr 20121271 INFLUENCE OF PATIENT-RELATED FACTORS ON SCREENING RESULTS FOR BLADDER CANCER USING FLUORESCENCE IN SITU HYBRIDIZATION Severine Banek, Christian Schwentner, Dirk taeger, Michael Nasterlack, Gabriele Leng, Beate Pesch, Karl-Dietrich Sievert, homas Bruening, and Arnulf Stenzl Severine BanekSeverine Banek Tuebingen, Germany More articles by this author , Christian SchwentnerChristian Schwentner Tuebingen, Germany More articles by this author , Dirk taegerDirk taeger Bochum, Germany More articles by this author , Michael NasterlackMichael Nasterlack Ludwigshafen, Germany More articles by this author , Gabriele LengGabriele Leng Leverkusen, Germany More articles by this author , Beate PeschBeate Pesch Bochum, Germany More articles by this author , Karl-Dietrich SievertKarl-Dietrich Sievert Tuebingen, Germany More articles by this author , homas Brueninghomas Bruening Bochum, Germany More articles by this author , and Arnulf StenzlArnulf Stenzl Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1603AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urine-based test are used for the early detection of bladder cancer (BC). However, there are interfering factors limiting the value of such systems.In a prospective study, we evaluated the diagnostic yield of FISH (Urovysion) for the screening of BC in a high-risk population. This analysis specifically focuses on the relevance of patient related factors for the diagnostic accuracy of Urovysion. METHODS 1,609 chemical workers with former exposure to aromatic amines, mean age 62 years, were examined. 7,091 preventive medical checkups were performed. Urine samples were collected for urine cytology and chromosomal aberrations were assessed by the UroVysion test. In case of at least one positive urine test, cystoscopy was performed. The influence of concomitant benign disease such as diabetes or benign prostate hyperplasia was evaluated. Urovysion was further investigated inherent patient-related factors including urine creatinine concentration, leukocyturia, hematuria and presence of crystalluria. RESULTS Urovysion could be determined in 6525 investigated samples. The most important influence on Urovysion was BC (OR 22.5, Cl 6.001-84.358). Altogether, Urovysion was significantly altered by smoking status (OR 2.241, Cl 1.122-4.478), crystalluria (OR 1.671, Cl 0.798-3.277) as well as urinary creatinine <0.5g/l (OR 2.67, Cl 1.571-4.535). A moderate influence was found by the presence of diabetes mellitus (OR 1.359, Cl 0.693 – 2.666). No influence could be observed due to leucocyturia (>5/μl), hematuria (>5Erys/μl) or benign prostatic hyperplasia (OR 1.121, 0.923 and 0.656, Cl 0.448–2.808, 0.521-1.635 and 0.089-4.823). CONCLUSIONS FISH results are altered by various patient-related factors. However, UroVysion can be applied in cases of urinary tract infection, hematuria and benign prostatic hyperplasia. Urovysion depends on numbers of cells in urine, which explains the influence of urinary creatinine and crystalluria. Given the fact that most BC patients are smokers Urovysion results should not be interpreted independently in this group of patients. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e514 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Severine Banek Tuebingen, Germany More articles by this author Christian Schwentner Tuebingen, Germany More articles by this author Dirk taeger Bochum, Germany More articles by this author Michael Nasterlack Ludwigshafen, Germany More articles by this author Gabriele Leng Leverkusen, Germany More articles by this author Beate Pesch Bochum, Germany More articles by this author Karl-Dietrich Sievert Tuebingen, Germany More articles by this author homas Bruening Bochum, Germany More articles by this author Arnulf Stenzl Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...