julilili42/papers huggingface dataset:
Relationship Between Big Five Personality Dimensions, Chronotype, and DSM-V Personality Disorders
2021-08-23

Morningness-eveningness (M/E) is an important variable in individual differences and has an impact on many areas of life including general and mental health. In previous work eveningness has shown to correlate to personality disorders (PDs) and mental instability such as psychoticism, depression, and bipolar disorders. Therefore, a relationship between M/E and PDs can be assumed but has never been tested. The aim of this study was to assess a possible relationship between DSM-5-PDs and circadian timing (chronotype; M/E). We used the Morningness-Eveningness Stability Scale improved and clock time-based measurements, the PID-5 brief version, and the Big Five brief version. Sample: N = 630; mean age: 27.76 years, SD: 11.36 years; 137 male, 489 female, 4 diverse. In this short screening a relationship between eveningness and DSM-5-personality traits, (evening-oriented participants showing a higher PID-5 score: morningness -0.208/ p &amp;lt; 0.001; eveningness: 0.153/ p &amp;lt; 0.001) was found. Moreover, participants with high levels of distinctness (fluctuations of the perceived energy level during the day) are prone to PDs too, with distinctness being the best predictor for a high PID-5 score in this sample (0.299/ p &amp;lt; 0.001). In the regression analysis, neuroticism, agreeableness, conscientiousness, and extraversion contributed significantly to the model with higher scores on extraversion, agreeableness and conscientiousness being related to lower scores on the PID-5. Neuroticism was positively related to PID-5 scores. Later midpoint of sleep (higher eveningness) was associated with higher PID-5 scores, as were higher fluctuations/amplitude during the day.
Separable Convolutions for Optimizing 3D Stereo Networks
2021-08-23

Deep learning based 3D stereo networks give superior performance compared to 2D networks and conventional stereo methods. However, this improvement in the performance comes at the cost of increased computational complexity, thus making these networks non-practical for the real-world applications. Specifically, these networks use 3D convolutions as a major work horse to refine and regress disparities. In this work first, we show that these 3D convolutions in stereo networks consume up to 94% of overall network operations and act as a major bottleneck. Next, we propose a set of "plug-&-run" separable convolutions to reduce the number of parameters and operations. When integrated with the existing state of the art stereo networks, these convolutions lead up to reduction in number of operations and up to reduction in parameters without compromising their performance. In fact these convolutions lead to improvement in their performance in the majority of cases <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> This work is part of the project DeepStereoVision (FRE: 01IS18024B) sponsored by the German Ministry of Education & Research (BMBF).
Thermotectonic constraints on the geodynamic evolution of the Pindos fold‐and‐thrust‐belt by low‐temperature (U–Th)/He thermochronometry
2021-08-23

This study presents new thermochronometric data to constrain the cooling history of the Pindos fold‐and‐thrust‐belt (PFTB) on the NW Peloponnese, and the timing of nappe stacking in the external Hellenides in western Greece. Low‐temperature thermochronology was performed on apatite and zircon minerals extracted from basal exposures of the PFBT in Mt. Erymanthos (NW Peloponnese) using the (U‐Th)/He system. Three bedrock samples collected from a profile across the strike of the PFBT returned thermochronometric ages for the apatite (AHe) between 15 and 9 Ma, while for the zircon (ZHe) the ages are interpreted as unreset (or partially reset). The AHe ages are interpreted as cooling ages related to the Cenozoic geodynamic evolution of the PFTB. Thermal models generated in this research demonstrate two phases of geodynamic evolution of the PFBT during the Cenozoic: an early one associated with the heating of the fold‐and‐thrust belt during 40–20 Ma and a later one associated with fast cooling from 20 Ma onwards. Heating is attributed to the structural thickening of the PFTB while cooling is associated with enhanced uplift and exhumation, which became widespread in Erymanthos by 9 Ma. The initiation of cooling on Mt. Erymanthos echoes the substantial geometric remodelling that underwent the Hellenic arc during the Middle Miocene, associated with slab rollback and arc extension, and is connected to the underplating of the internal segments of the external platform (Gavrovo‐Tripolis unit) by the external metamorphic segments (Mani and Arna units). The current inverse thermal modelling offers the first continuous description of the geodynamic evolution of the most prominent fold‐and‐thrust belt of the Hellenides, from the oceanic stage through basin inversion to uplift and orogen decay.
An Ylidic Cp and its Scandium Complexes in Equilibrium
2021-08-23

Scandium complexes bearing a C-ylidic, electron-deficient Cp ligand are presented by starting from [ScCl3(thf)3]. As ylidic ligands do not require salt metathesis, the coordination of the Cp ligand is realized by mere substitution of the tetrahydrofuran ligands. In acetonitrile an equilibrium among the free ligand, the half-sandwich complex, and the cationic metallocene with its tetrachloridoscandate counterion is observed via NMR spectroscopy. This equilibrium is fully confirmed by 1H and 45Sc NMR EXSY experiments. In the absence of coordinating solvents, the selective formation of all compounds of the equilibrium has been achieved, and the structures have been confirmed by NMR spectroscopy and X-ray structure analysis. Especially 45Sc NMR spectroscopy reveals signals with characteristic chemical shifts for the half-sandwich complex and the metallocene. With scandium triflate the corresponding scandocene is also accessible.
Cognitive decline in Huntington’s disease in the Digitalized Arithmetic Task (DAT)
2021-08-23

Background Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington’s disease (HD) patients are lacking in HD research. We thus developed and assessed the digitized arithmetic task (DAT), which combines inner language and executive functions in approximately 4 minutes. Methods We assessed the psychometric properties of DAT in three languages, across four European sites, in 77 early-stage HD patients (age: 52 ± 11 years; 27 females), and 57 controls (age: 50 ± 10, 31 females). Forty-eight HD patients and 34 controls were followed up to one year with 96 participants who underwent MRI brain imaging (HD patients = 46) at baseline and 50 participants (HD patients = 22) at one year. Linear mixed models and Pearson correlations were used to assess associations with clinical assessment. Results At baseline, HD patients were less accurate (p = 0.0002) with increased response time (p&lt;0.0001) when compared to DAT in controls. Test-retest reliability in HD patients ranged from good to excellent for response time (range: 0.63–0.79) and from questionable to acceptable for accuracy (range: r = 0.52–0.69). Only DAT, the Mattis Dementia Rating Scale, the Symbol Digit Modalities Test, and Total Functional Capacity scores were able to detect a decline within a one-year follow-up in HD patients (all p&lt; 0.05). In contrast with all the other cognitive tasks, DAT correlated with striatal atrophy over time (p = 0.037) but not with motor impairment. Conclusions DAT is fast, reliable, motor-free, applicable in several languages, and able to unmask cognitive decline correlated with striatal atrophy in small cohorts of HD patients. This likely makes it a useful endpoint in future trials for HD and other neurodegenerative diseases.
Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice
2021-08-23

ABSTRACT Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs. In addition, plasminogen (Plg) has been reported to play a role in glomerular damage. Here, we investigated the interdependence of both factors for the development of DIN. Genotyping confirmed the SNP of the Prkdc gene in C57BL/6 (PrkdcC6418/C6418) and 129S1/SvImJ (PrkdcT6418/T6418) mice. Intercross of heterozygous 129SB6F1 mice led to 129SB6F2 hybrids with Mendelian inheritance of the SNP. After doxorubicin injection, only homozygous F2 mice with PrkdcT6418/T6418 developed proteinuria. Genetic deficiency of Plg (Plg−/−) in otherwise susceptible 129S1/SvImJ mice led to resistance to DIN. Immunohistochemistry revealed glomerular binding of Plg in Plg+/+ mice after doxorubicin injection involving histone H2B as Plg receptor. In doxorubicin-resistant C57BL/6 mice, Plg binding was absent. In conclusion, susceptibility to DIN in 129S1/SvImJ mice is determined by a hierarchical two-hit process requiring the C6418T SNP in the Prkdc gene and subsequent glomerular binding of Plg. This article has an associated First Person interview with the first author of the paper.
Object Detection And Autoencoder-Based 6d Pose Estimation For Highly Cluttered Bin Picking
2021-08-23

Bin picking is a core problem in industrial environments and robotics, with its main module as 6D pose estimation. However, industrial depth sensors have a lack of accuracy when it comes to small objects. Therefore, we propose a framework for pose estimation in highly cluttered scenes with small objects, which mainly relies on RGB data and makes use of depth information only for pose refinement. In this work, we compare synthetic data generation approaches for object detection and pose estimation and introduce a pose filtering algorithm that determines the most accurate estimated poses. We will make our
Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis
2021-08-24

Background Systemic sclerosis (SSc) is an autoimmune disease characterized by overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing cells in immunofibrotic disorders. So far, involvement of monocytes and macrophages in the fibrogenesis of SSc remains poorly understood. Methods and Results Immunohistochemistry analysis showed accumulation of CD14 + monocytes in the collagen-rich areas, as well as increased amount of alpha smooth muscle actin (αSMA)-positive fibroblasts, CD68 + and mannose-R + macrophages in the heart and lungs of SSc patients. The full genome transcriptomics analyses of CD14 + blood monocytes revealed dysregulation in cytoskeleton rearrangement, ECM remodeling, including elevated FN1 (gene encoding fibronectin) expression and TGF-β signalling pathway in SSc patients. In addition, single cell RNA sequencing analysis of tissue-resident CD14 + pulmonary macrophages demonstrated activated profibrotic signature with the elevated FN1 expression in SSc patients with interstitial lung disease. Peripheral blood CD14 + monocytes obtained from either healthy subjects or SSc patients exposed to profibrotic treatment with profibrotic cytokines TGF-β, IL-4, IL-10, and IL-13 increased production of type I collagen, fibronectin, and αSMA. In addition, CD14 + monocytes co-cultured with dermal fibroblasts obtained from SSc patients or healthy individuals acquired a spindle shape and further enhanced production of profibrotic markers. Pharmacological blockade of the TGF-β signalling pathway with SD208 (TGF-β receptor type I inhibitor), SIS3 (Smad3 inhibitor) or (5Z)-7-oxozeaenol (TGF-β-activated kinase 1 inhibitor) ameliorated fibronectin levels and type I collagen secretion. Conclusions Our findings identified activated profibrotic signature with elevated production of profibrotic fibronectin in CD14 + monocytes and CD14 + pulmonary macrophages in SSc and highlighted the capability of CD14 + monocytes to acquire a profibrotic phenotype. Taking together, tissue-infiltrating CD14 + monocytes/macrophages can be considered as ECM producers in SSc pathogenesis.
Physiological variables in association with spreading depolarizations in the late phase of ischemic stroke
2021-08-24

Physiological effects of spreading depolarizations (SD) are only well studied in the first hours after experimental stroke. In patients with malignant hemispheric stroke (MHS), monitoring of SDs is restricted to the postoperative ICU stay, typically day 2-7 post-ictus. Therefore, we investigated the role of physiological variables (temperature, intracranial pressure, mean arterial pressure and cerebral perfusion pressure) in relationship to SD during the late phase after MHS in humans. Additionally, an experimental stroke model was used to investigate hemodynamic consequences of SD during this time window. In 60 patients with MHS, the occurrence of 1692 SDs was preceded by a decrease in mean arterial pressure (−1.04 mmHg; p = .02) and cerebral perfusion pressure (−1.04 mmHg; p = .03). Twenty-four hours after middle cerebral artery occlusion in 50 C57Bl6/J mice, hypothermia led to prolonged SD-induced hyperperfusion (+2.8 min; p &lt; .05) whereas hypertension mitigated initial hypoperfusion (−1.4 min and +18.5%Δ rCBF; p &lt; .01). MRI revealed that SDs elicited 24 hours after experimental stroke were associated with lesion progression (15.9 vs. 14.8 mm3; p &lt; .01). These findings of small but significant effects of physiological variables on SDs in the late phase after ischemia support the hypothesis that the impact of SDs may be modified by adjusting physiological variables.
Binding of boswellic acids to functional proteins of the SARS‐CoV‐2 virus: Bioinformatic studies
2021-08-24

Abstract Boswellic acids (BAs) have been shown to possess antiviral activity. Using bioinformatic methods, it was tested whether or not acetyl‐11‐keto‐β‐boswellic acid (AKBA), 11‐keto‐β‐boswellic acid (KBA), β‐boswellic acid (BBA), and the phosphorylated active metabolite of Remdesivir® (RGS‐P3) bind to functional proteins of SARS‐CoV‐2, that is, the replicase polyprotein P0DTD1, the spike glycoprotein P0DTC2, and the nucleoprotein P0DTC9. Using P0DTD1, AKBA and KBA showed micromolar binding affinity to the RNA‐dependent RNA polymerase (RdRp) and to the main proteinase complex M pro . Phosphorylated BAs even bond in the nanomolar range. Due to their positive and negative charges, BAs and RGS‐P3 bond to corresponding negative and positive areas of the protein. BAs and RGS‐P3 docked in the tunnel‐like cavity of RdRp. BAs also docked into the elongated surface rim of viral M pro . In both cases, binding occurred with active site amino acids in the lower micromolecular to upper nanomolar range. KBA, BBA, and RGS‐P3 also bond to P0DTC2 and P0DTC9. The binding energies for BAs were in the range of −5.8 to −6.3 kcal/mol. RGS‐P3 and BAs occluded the centrally located pore of the donut‐like protein structure of P0DTC9 and, in the case of P0DTC2, RGS‐P3 and BAs impacted the double‐wing‐like protein structure. The data of this bioinformatics study clearly show that BAs bind to three functional proteins of the SARS‐CoV‐2 virus responsible for adhesion and replication, as does RGS‐P3, a drug on the market to treat this disease. The binding effectiveness of BAs can be increased through phosphate esterification. Whether or not BAs are druggable against the SARS‐CoV‐2 disease remains to be established.
Proteome Dynamics during Antibiotic Persistence and Resuscitation
2021-08-24

While bactericidal antibiotics typically require actively growing cells to exploit their function, persister cells are slowly replicating which makes them tolerant to the lethal action of antimicrobials. Here, we used an established in vitro model of bacterial persistence based on overexpression of the paradigm toxin-antitoxin (TA) system hipA / hipB to devise a generic method for temporal analysis of protein synthesis during toxin-induced persistence and antitoxin-mediated resuscitation.
SLM-based interferometer for assessing the polychromatic neural transfer function of the eye
2021-08-24

A novel interferometric instrument for measuring neural transfer function (NTF) of the eye is presented. The device is based on a liquid-crystal-on-silicon spatial light modulator (SLM), which is used to create two laterally separated wavefronts in the pupil plane of the eye that interfere on the retina. The phase mask on the SLM, consisting of two diffraction gratings mixed in a checkerboard pattern and acting as a shearing interferometer, allows independent control of spatial frequency, orientation, and contrast of the fringes, as well as the field of view in a wide polychromatic spectrum. Coupled with a supercontinuum source, the system is able to produce achromatic fringes on the retina. The instrument was successfully tested in six normal subjects in four light conditions: polychromatic light and monochromatic blue, green and red light respectively (central wavelengths - 450, 550 and 650 nm). On average, the NTF in polychromatic light was approximately 20% higher than for green and red light, although not statistically significant due to high intersubject variability. Due to all-digital control of the interference fringes, the device is optically simple and virtually unsusceptible to vibrations, allowing its use in a non-laboratory environment. The study also contributes to color vision research, allowing to evaluate contrast sensitivity function without monochromatic or chromatic aberrations.
Biophysical targeting of high‐risk cerebral aneurysms
2021-08-24

Abstract Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms, lesions in brain arteries, may offer a new treatment paradigm. Since aneurysm rupture leading to subarachnoid hemorrhage is a devastating medical emergency with high mortality, the ability to noninvasively diagnose high‐risk aneurysms is of paramount importance. Moreover, treatment of unruptured aneurysms with invasive surgery or minimally invasive neurointerventional surgery poses relatively high risk and there is presently no medical treatment of aneurysms. Here, leveraging the endogenous biophysical properties of brain aneurysms, we develop particulate carriers designed to localize in aneurysm low‐shear flows as well as to adhere to a diseased vessel wall, a known characteristic of high‐risk aneurysms. We first show, in an in vitro model, flow guided targeting to aneurysms using micron‐sized (2 μm) particles, that exhibited enhanced targeting (&gt;7 folds) to the aneurysm cavity while smaller nanoparticles (200 nm) showed no preferable accumulation. We then functionalize the microparticles with glycoprotein VI (GPVI), the main platelet receptor for collagen under low‐medium shear, and study their targeting in an in vitro reconstructed patient‐specific aneurysm that contained a disrupted endothelium at the cavity. Results in this model showed that GPVI microparticles localize at the injured aneurysm an order of magnitude (&gt;9 folds) more than control particles. Finally, effective targeting to aneurysm sites was also demonstrated in an in vivo rabbit aneurysm model with a disrupted endothelium. Altogether, the presented biophysical strategy for targeted delivery may offer new treatment opportunities for cerebral aneurysms.
Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophrenia
2021-08-24

Abstract Excessive synapse loss is a core feature of schizophrenia and is linked to the complement component 4A gene ( C4A ). In two independent cohorts, we show that cerebrospinal fluid (CSF) C4A concentration is elevated in first-episode psychosis patients who develop schizophrenia and correlates with CSF measurements of synapse density. Using patient-derived cellular modeling, we find that disease-associated cytokines increase neuronal C4A expression and that IL-1β associates with C4A in patient-derived CSF.
A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913
2021-08-24

Abstract Upon recognition of aberrantly located DNA, the innate immune sensor cGAS activates STING/IRF-3-driven antiviral responses. Here we characterized the ability of a specific variant of the cGAS-encoding gene MB21D1 , rs610913, to alter cGAS-mediated DNA sensing and viral infection. rs610913 is a frequent G&gt;T polymorphism resulting in a P 261 H exchange in the cGAS protein. Data from the International Collaboration for the Genomics of HIV suggested that rs610913 nominally associates with HIV-1 acquisition in vivo . Molecular modeling of cGAS(P 261 H) hinted towards the possibility for an additional binding site for a potential cellular co-factor in cGAS dimers. However, cGAS(WT) or cGAS(P 261 H)-reconstituted THP-1 cGAS KO cells shared steady-state expression of interferon-stimulated genes (ISGs), as opposed to cells expressing the enzymatically inactive cGAS(G 212 A/S 213 A). Accordingly, cGAS(WT) and cGAS(P 261 H) cells were less susceptible to lentiviral transduction and infection with HIV-1, HSV-1, and Chikungunya virus as compared to cGAS KO- or cGAS(G 212 A/S 213 A) cells. Upon DNA challenge, innate immune activation appeared to be mildly reduced upon expression of cGAS(P 261 H) compared to cGAS(WT). Finally, DNA challenge of PBMCs from donors homozygously expressing rs610913 provoked a trend towards a slightly reduced type I IFN response as compared to PBMCs from GG donors. Taken together, the steady-state activity of cGAS maintains a base-line antiviral state rendering cells more refractory to ISG-sensitive viral infections. Even though rs610913 failed to grossly differ phenotypically from the wild-type gene, its expression potentially results in a slightly altered susceptibility to viral infections in vivo .
On the Role of Heterojunctions of Core-Shell Heterostructures in Gas Sensing
2021-08-24

Heterostructures made from semiconducting metal oxides (SMOX) are fundamental for the development of high-performance gas sensors. Yet, despite the recognition of their importance in real applications, the understanding of the transduction mechanism either related to the heterojunction, or simply to the core and shell materials is still lacking. A better understanding of the sensing response of heterostructured nanomaterials requires the engineering of heterojunctions with well-defined core and shell layers. Here, we introduce a series of prototypes nSMOX-CNT, pSMOX-CNT, and pSMOX-nSMOX-CNT and nSMOX-pSMOX-CNT hierarchical core-shell heterostructures (CSHS) permitting us to directly relate the sensing response to the SMOX shell, or to the p-n heterojunction. The carbon nanotubes are here used as highly conductive substrates permitting to operate the devices at relatively low temperature and are not involved in the sensing response. NiO and SnO2 are selected as representative p- and n-type SMOX, respectively, and the response of a set of samples is studied toward hydrogen considered as model analyte. The n,pSMOX-CNT CSHS exhibit response related to the n,pSMOX-shell layer. On the other hand, the pSMOX-nSMOX-CNT and nSMOX-pSMOX-CNT CSHS show sensing responses, which in certain cases are governed by the heterojunctions between nSMOX and pSMOX and strongly depends on the thickness of the SMOX layers. Due to the fundamental nature of this study, these findings are important for the development of next generation gas sensing devices.