julilili42/papers huggingface dataset:
These Are Not the Effects You Are Looking for: Causality and the Within-/Between-Persons Distinction in Longitudinal Data Analysis
2023-01-01

In psychological science, researchers often pay particular attention to the distinction between within- and between-persons relationships in longitudinal data analysis. Here, we aim to clarify the relationship between the within- and between-persons distinction and causal inference and show that the distinction is informative but does not play a decisive role in causal inference. Our main points are threefold. First, within-persons data are not necessary for causal inference; for example, between-persons experiments can inform about (average) causal effects. Second, within-persons data are not sufficient for causal inference; for example, time-varying confounders can lead to spurious within-persons associations. Finally, despite not being sufficient, within-persons data can be tremendously helpful for causal inference. We provide pointers to help readers navigate the more technical literature on longitudinal models and conclude with a call for more conceptual clarity: Instead of letting statistical models dictate which substantive questions researchers ask, researchers should start with well-defined theoretical estimands, which in turn determine both study design and data analysis.
The impact of social pretend play on preschoolers’ social development: Results of an experimental study
2023-01-01

This controlled intervention study with a pre-test, post-test, and follow-up design investigated whether promoting children's social pretend play quality fosters their social development. Twenty-seven Swiss playgroups (N = 211 children, age: M = 43.3 months, SD= 6.5, with a median of 7 children per group) were randomly assigned to one of three experimental conditions: Play tutoring, provision of role play material, or control. Standardized tests and educator questionnaires were used to assess children's social pretend play competence and social-cognitive, emotional and social skills as well as their peer relationship quality. Latent change models indicated that children's social pretend play competence, behavioral skills, and positive peer relationships as reported by their educators increased most strongly for children in the play tutoring condition. No significant intervention effects emerged regarding children's social-cognitive or emotional skills. The results show that actively promoting children's social pretend play quality also fosters their social behavior and peer relationships.
Climate Security in the Anthropocene
2023-01-01

Systematic study of different framings of climate security &amp; policy responses by United Nations Security Council membersInnovative framework &amp; methodology that uses multiple security approaches including traditional, human, and ecologicalCase studies written by local, experienced researchers drawing from an extensive number of primary and secondary sources
Artificial Intelligence in Reproductive Medicine – An Ethical Perspective
2023-01-01

Abstract Artificial intelligence is steadily being integrated into all areas of medicine. In reproductive medicine, artificial intelligence methods can be utilized to improve the selection and prediction of sperm cells, oocytes, and embryos and to generate better predictive models for in vitro fertilization. The use of artificial intelligence in this field is justified by the suffering of persons or couples who wish to have children but are unable to conceive. However, research into the use of artificial intelligence in reproductive medicine is still in the early experimental stage and furthermore raises complex normative questions. There are ethical research challenges because evidence of the efficacy of certain pertinent systems is often lacking and because of the increased difficulty of ensuring informed consent on the part of the affected persons. Other ethically relevant issues include the potential risks for offspring and the difficulty of providing sufficient information. The opportunity to fulfill the desire to have children affects the welfare of patients and their reproductive autonomy. Ultimately, ensuring more accurate predictions and allowing physicians to devote more time to their patients will have a positive effect. Nevertheless, clinicians must be able to process patient data conscientiously. When using artificial intelligence, numerous actors are involved in making the diagnosis and deciding on the appropriate therapy, raising questions about who is ultimately responsible when mistakes occur. Questions of fairness arise with regard to resource allocation and cost reimbursement. Thus, before implementing artificial intelligence in clinical practice, it is necessary to critically examine the quantity and quality of the data used and to address issues of transparency. In the medium and long term, it would be necessary to confront the undesirable impact and social dynamics that may accompany the use of artificial intelligence in reproductive medicine.
Findings of the VarDial Evaluation Campaign 2023
2023-01-01

This report presents the results of the shared tasks organized as part of the VarDial Evaluation Campaign 2023. The campaign is part of the tenth workshop on Natural Language Processing (NLP) for Similar Languages, Varieties and Dialects (VarDial), co-located with EACL 2023. Three separate shared tasks were included this year: Slot and intent detection for low-resource language varieties (SID4LR), Discriminating Between Similar Languages – True Labels (DSL-TL), and Discriminating Between Similar Languages – Speech (DSL-S). All three tasks were organized for the first time this year.
Recent advances in molybdenum diselenide-based electrocatalysts: preparation and application in the hydrogen evolution reaction
2023-01-01

This review summarizes the preparation of MoSe 2 -based materials, their application in hydrogen evolution reaction (HER), the catalytic mechanism for improved HER performance, structure–performance correlations and the challenges in the future.
Challenges in natural product-based drug discovery assisted within silico-based methods
2023-01-01

This review uses documented studies to highlight current difficulties faced by natural product drug discovery scientists using in silico methods. This will provide interested scientists in this field of research an idea of what they can expect.
Medical Students’ Attitudes Toward AI in Medicine and their Expectations for Medical Education
2023-01-01

Objectives Artificial intelligence (AI) is used in a variety of contexts in medicine. This involves the use of algorithms and software that analyze digital information to make diagnoses and suggest adapted therapies. It is unclear, however, what medical students know about AI in medicine, how they evaluate its application, and what they expect from their medical training accordingly. In the study presented here, we aimed at providing answers to these questions. Methods In this survey study, we asked medical students about their assessment of AI in medicine and recorded their ideas and suggestions for considering this topic in medical education. Fifty-eight medical students completed the survey. Results Almost all participants were aware of the use of AI in medicine and had an adequate understanding of it. They perceived AI in medicine to be reliable, trustworthy, and technically competent, but did not have much faith in it. They considered AI in medicine to be rather intelligent but not anthropomorphic. Participants were interested in the opportunities of AI in the medical context and wanted to learn more about it. They indicated that basic AI knowledge should be taught in medical studies, in particular, knowledge about modes of operation, ethics, areas of application, reliability, and possible risks. Conclusions We discuss the implications of these findings for the curricular development in medical education. Medical students need to be equipped with the knowledge and skills to use AI effectively and ethically in their future practice. This includes understanding the limitations and potential biases of AI algorithms by teaching the sensible use of human oversight and continuous monitoring to catch errors in AI algorithms and ensure that final decisions are made by human clinicians.
Ankle fractures of the geriatric patient: a narrative review
2023-01-01

The present narrative review provides a summary of current concepts for the treatment of ankle fractures in elderly patients. Despite a high complication rate, open reduction and internal fixation is the gold standard for operative care. However, individual patient-based treatment decision considering the soft-tissue status, the fracture pattern, as well as the patient’s mobility and comorbidities is mandatory to achieve sufficient patient outcomes. Due to high complication rates after surgery in the past, techniques such as fibular nails or minimal invasive techniques should be considered.
Cognitive Behavioral Therapy for Late-Life Depression (CBTlate): Results of a Multicenter, Randomized, Observer-Blinded, Controlled Trial
2023-01-01

Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. Methods: In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. Results: Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. Conclusions: Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.
The Gaze and Mouse Signal as Additional Source for User Fingerprints in Browser Applications
2023-01-01

In this work we inspect different data sources for browser fingerprints. We show which disadvantages and limitations browser statistics have and how this can be avoided with other data sources. Since human visual behavior is a rich source of information and also contains person specific information, it is a valuable source for browser fingerprints. However, human gaze acquisition in the browser also has disadvantages, such as inaccuracies via webcam and the restriction that the user must first allow access to the camera. However, it is also known that the mouse movements and the human gaze correlate and therefore, the mouse movements can be used instead of the gaze signal. In our evaluation we show the influence of all possible combinations of the three information sources for user recognition and describe our simple approach in detail. The data and the Matlab code can be downloaded here this https URL&mode=list
Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes
2023-01-01

Abstract The stringent response and its signalling nucleotides, pppGpp and ppGpp, have been the subject of intense research since the discovery of (p)ppGpp in 1969. Recent studies have revealed that the downstream events that follow (p)ppGpp accumulation vary among species. Consequently, the stringent response as initially characterized in Escherichia coli largely differs from the response in Firmicutes (Bacillota), wherein synthesis and degradation of the messengers (p)ppGpp are orchestrated by the bifunctional Rel enzyme with synthetase and hydrolase activity and the two synthetases SasA/RelP and SasB/RelQ. Here we will summarize recent studies supporting the role of (p)ppGpp in the development of antibiotic resistance and tolerance as well as survival under adverse environmental conditions in Firmicutes. We will also discuss the impact of elevated (p)ppGpp levels on the development of persister cells and the establishment of persistent infections. (p)ppGpp levels are usually tightly controlled to allow optimal growth under non-stressed conditions. Upon the onset of certain ‘stringent conditions’ the sudden increase in (p)ppGpp levels limits growth while exerting protective effects. In Firmicutes, the (p)ppGpp-mediated restriction of GTP accumulation is one major mechanism of protection and survival under stresses such as antibiotic exposure.
Spinocerebellar ataxia 27B: episodic symptoms and acetazolamide response in 34 patients
2023-01-01

Ashton C et al report a retrospective multi-centre cohort of 34 patients from Canada, France, Austria and Australia with spinocerebellar ataxia 27B, describing the common feature of episodic ataxia and other episodic features, as well as the inefficacy of acetazolamide in these patients.
1st Workshop on Maritime Computer Vision (MaCVi) 2023: Challenge Results
2023-01-01

The 1st Workshop on Maritime Computer Vision (MaCVi) 2023 focused on maritime computer vision for Unmanned Aerial Vehicles (UAV) and Unmanned Surface Vehicle (USV), and organized several subchallenges in this domain: (i) UAV-based Maritime Object Detection, (ii) UAV-based Mar-itime Object Tracking, (iii) USV-based Maritime Obstacle Segmentation and (iv) USV-based Maritime Obstacle Detection. The subchallenges were based on the SeaDronesSee and MODS benchmarks. This report summarizes the main findings of the individual subchallenges and introduces a new benchmark, called SeaDronesSee Object Detection v2, which extends the previous benchmark by including more classes and footage. We provide statistical and qualitative analyses, and assess trends in the best-performing method-ologies of over 130 submissions. The methods are sum-marized in the appendix. The datasets, evaluation code and the leaderboard are publicly available (https://seadronessee.cs.uni-tuebingen.de/macvi). © 2023 IEEE.
Inhibitory Control Training Enhanced by Transcranial Direct Current Stimulation to Reduce Binge Eating Episodes: Findings from the Randomized Phase II ACCElect Trial
2023-01-01

Introduction: Binge eating disorder (BED) is characterized by recurrent binge eating (BE) episodes with loss of control. Inhibitory control impairments, including alterations in dorsolateral prefrontal cortex (dlPFC) functioning, have been described for BED. A targeted modulation of inhibitory control circuits by the combination of inhibitory control training and transcranial brain stimulation could be promising. Objective: The aim of the study was to demonstrate feasibility and clinical effects of a transcranial direct current stimulation (tDCS)-enhanced inhibitory control training to reduce BE episodes and to generate an empirical basis for a confirmatory trial. Methods: We performed a monocentric clinical phase II double-blind randomized trial with two parallel arms. Forty-one adult outpatients with full-syndrome BED according to DSM-5 received six sessions of food-related inhibitory control training, randomly combined with 2 mA verum or sham tDCS of the right dlPFC. The main outcome was BE frequency within a 4-week interval after treatment termination (T8; primary) and at 12-week follow-up (T9; secondary) as compared to baseline. Results: BE frequency was reduced in the sham group from 15.5 to 5.9 (T8) and to 6.8 (T9); in the verum group, the reduction was 18.6 to 4.4 (T8) resp. 3.8 (T9). Poisson regression with the study arm as the factor and baseline BE frequency as the covariate revealed a p value of 0.34 for T8 and 0.026 for T9. Sham and real tDCS differed at T9 in BE frequency. Conclusions: Inhibitory control training enhanced by tDCS is safe in patients with BED and results in a substantial and sustainable reduction in BE frequency which unfolds over several weeks post-treatment. These results constitute the empirical basis for a confirmatory trial.
Covalent chemical probes for protein kinases
2023-01-01

Small-molecule chemical probes are crucial tools to study the function of unexplored proteins in biological systems, thereby directly impacting preclinical target validation. Being one of the largest protein families in humans, protein kinases are currently among the most important and fruitful molecular targets in drug discovery. However, a significant fraction of the human "kinome" is still understudied and growing efforts in the scientific community aim at the development of specific chemical tool compounds for such "dark" kinases. Covalent targeting has proven to be a valid and rational strategy towards high-quality chemical probes enabling superior potencies, high selectivities and sustained target engagement. In the kinase field, the targeting of non-catalytic cysteine residues has been particularly fruitful and there is an increasing interest in addressing other residues, such as lysine or tyrosine. Herein, we discuss the properties and generation of covalent kinase inhibitors, with a special emphasis on electrophilic functional groups that can be used as "warheads". Moreover, we highlight studies showcasing the development of covalent chemical probes targeting cysteine and lysine residues in an irreversible or reversible-covalent manner.
Resolved near-UV hydrogen emission lines at 40-Myr super-Jovian protoplanet Delorme 1 (AB)b
2023-01-01

Context. Accretion at planetary-mass companions (PMCs) suggests the presence of a protoplanetary disc in the system, likely accompanied by a circumplanetary disc. High-resolution spectroscopy of accreting PMCs is very difficult due to their proximity to bright host stars. For well-separated companions, however, such spectra are feasible and they are unique windows into accretion. Aims. We have followed up on our observations of the 40-Myr, and still accreting, circumbinary PMC Delorme 1 (AB)b. We used high-resolution spectroscopy to characterise the accretion process further by accessing the wealth of emission lines in the near-UV. Methods. We have used the UVES spectrograph on the ESO VLT/UT2 to obtain R λ ≈ 50 000 spectroscopy, at 3300–4520 Å, of Delorme 1 (AB)b. After separating the emission of the companion from that of the M5 low-mass binary, we performed a detailed emission-line analysis, which included planetary accretion shock modelling. Results. We reaffirm ongoing accretion in Delorme 1 (AB)b and report the first detections in a (super-Jovian) protoplanet of resolved hydrogen line emission in the near-UV (H γ , H δ , H ε , H8, and H9). We tentatively detect H11, H12, He I , and Ca II H/K. The analysis strongly favours a planetary accretion shock with a line-luminosity-based accretion rate of Ṁ = 2 × 10 −8 M J yr −1 . The lines are asymmetric and are well described by sums of narrow and broad components with different velocity shifts. The overall line shapes are best explained by a pre-shock velocity of v 0 = 170 ± 30 km s −1 , implying a planetary mass of M P = 13 ± 5 M J , and number densities of n 0 ≳ 10 13 cm −3 or n 0 ∼ 10 11 cm −3 . The higher density implies a small line-emitting area of ∼1% relative to the planetary surface. This favours magnetospheric accretion, a case potentially strengthened by the presence of blueshifted emission in the line profiles. Conclusions. High-resolution spectroscopy offers the opportunity to resolve line profiles, which are crucial for studying the accretion process in depth. The super-Jovian protoplanet Delorme 1 (AB)b is still accreting at ∼40 Myr. Thus, Delorme 1 belongs to the growing family of ‘Peter Pan disc’ systems with (a) protoplanetary and/or circumplanetary disc(s) far beyond the typically assumed disc lifetimes. Further observations of this benchmark companion and its presumed disc(s) will help answer key questions about the accretion geometry in PMCs.
Spectral Induced Polarization (SIP) of Denitrification‐Driven Microbial Activity in Column Experiments Packed With Calcareous Aquifer Sediments
2023-01-01

Abstract Spectral Induced Polarization (SIP) has been suggested as a non‐invasive monitoring proxy for microbial processes. Under natural conditions, however, multiple and often coupled polarization processes co‐occur, impeding the interpretation of SIP signals. In this study, we analyze the sensitivity of SIP to microbially‐driven reactions under quasi‐natural conditions. We conducted flow‐through experiments in columns equipped with SIP electrodes and filled with natural calcareous, organic‐carbon‐rich aquifer sediment, in which heterotrophic denitrification was bio‐stimulated. Our results show that, even in the presence of parallel polarization processes in a natural sediment under field‐relevant geochemical conditions, SIP is sufficiently sensitive to microbially‐driven changes in electrical charge storage. Denitrification yielded an increase in imaginary conductivity of up to 3.1 (+140%) and the formation of a distinct peak between 1 and 10 Hz, that matched the timing of expected microbial activity predicted by a reactive transport model fitted to solute concentrations. A Cole‐Cole decomposition allowed separating the polarization contribution of microbial activity from that of cation exchange, thereby helping to locate microbial hotspots without the need for (bio)geochemical data to constrain the Cole‐Cole parameters. Our approach opens new avenues for the application of SIP as a rapid method to monitor a system's reactivity in situ. While in preceding studies the SIP signals of microbial activity in natural sediments were influenced by mineral precipitation/dissolution reactions, the imaginary conductivity changes measured in the biostimulation experiments presented here were dominated by changes in the polarization of the bacterial cells rather than a reaction‐induced alteration of the abiotic matrix.