julilili42/papers huggingface dataset:
[18F]Fluoride Positron-Emission Tomography (PET) and [18F]FDG PET for Assessment of Osteomyelitis of the Jaw in Comparison to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI): A Prospective PET/CT and PET/MRI Pilot Study
2022-07-10

To investigate imaging features of osteomyelitis of the jaw (OMJ) using [18F]fluoride positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)-PET compared with computed tomography (CT) and magnetic resonance imaging (MRI) to assess extent and disease activity. Six female patients (55.3 ± 10.0 years) were enrolled for assessment of symptomatic OMJ. 4/6 patients underwent [18F]FDG-PET/MRI and [18F]fluoride-PET/CT, one patient MRI and [18F]fluoride-PET/CT and another patient only [18F]FDG-PET/MRI. Image analysis was performed by two radiologists, an oral and maxillofacial surgeon, and a nuclear medicine specialist. The extent of affected jawbone was analyzed both qualitatively and quantitatively, including the PET tracer uptake, CT-Hounsfield-Units (HU) and MRI parameters in affected and healthy jawbone. All patients had trabecular sclerosis in the affected jawbone compared to healthy jawbone (560 ± 328 HU vs. 282 ± 211 HU; p &gt; 0.05), while 3/6 patients had cortical erosions. Bone marrow edema and gadolinium enhancement were documented in 5/6 patients. In affected jawbone, [18F]fluoride-uptake was increased in all patients compared to healthy jawbone (SUVmean 15.4 ± 4.2 vs. 2.1 ± 0.6; p &lt; 0.05), and [18F]FDG-uptake was moderately higher (SUVmean 1.9 ± 0.7 vs. 0.7 ± 0.2; p &gt; 0.05). The extent of regions with increased metabolic activity was less than the extent of morphologic changes in all patients. Information on jawbone metabolism and inflammation is different from morphologic changes and therefore has the potential to provide a more accurate and objective assessment of the extent and activity of OMJ.
‘Student tutors go online’ - Investigation of cognitive and social congruence in online student tutorials - a longitudinal study
2022-07-10

The concept of peer-assisted learning (PAL) has been implemented at many medical faculties. Due to the Covid-19 pandemic, parts of the medical education experience transitioned to digital formats. However, little is known about PAL and online student tutorials. PAL is effective due to cognitive and social congruence. This study aims to investigate these concepts in an online student tutorial on taking a patient's medical history. This longitudinal study took place in a preclinical communication course on how to take a patient's medical history. In an online student tutorial, the students learned how to take a patient's psychosocial medical history. Using standardised questionnaires, cognitive and social congruence were assessed. T-tests of independent samples were performed for data comparison. The participants included 128 second-year medical students and 5 student tutors. Cognitive congruence (M<sub>student</sub> = 4.19 ± 0.56; M<sub>studenttutor</sub> = 4.04 ± 0.57) and social congruence (M<sub>Student</sub> = 4.25 ± 0.56; M<sub>Studenttutor</sub> = 4.06 ± 0.57) were high for both students and student tutors in the online setting. In comparison to the face-to-face group, students in the online setting considered the student tutors to be significantly (p < .05) more socially congruent. Learning success increased during the course; however, it was not influenced by cognitive congruence. Cognitive and social congruence are high in an online setting. The students' learning success increased during the online tutorial. Based on the higher level of social congruence, student tutors might be very motivated to be open and approachable in an online setting. Simultaneously, students might pay more attention and participate actively in the online setting. Social and cognitive congruence contribute to the effectiveness of online student tutorials and, thus, online student tutorials should be integrated into medical training.
Tide-Triggered Production of Reactive Oxygen Species in Coastal Soils
2022-07-11

We report an unrecognized, tidal source of reactive oxygen species (ROS). Using a newly developed ROS-trapping gel film, we observed hot spots for ROS generation within ∼2.5 mm of coastal surface soil. Kinetic analyses showed rapid production of hydroxyl radicals (<sup>•</sup>OH), superoxide (O<sub>2</sub><sup>•-</sup>), and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) upon a shift from high tide to low tide. The ROS production exhibited a distinct rhythmic fluctuation. The oscillations of the redox potential and dissolved oxygen concentration followed the same pattern as the <sup>•</sup>OH production, suggesting the alternating oxic-anoxic conditions as the main geochemical drive for ROS production. Nationwide coastal field investigations confirmed the widespread and sustainable production of ROS via tidal processes (22.1-117.4 μmol/m<sup>2</sup>/day), which was 5- to 36-fold more efficient than those via classical photochemical routes (1.5-7.6 μmol/m<sup>2</sup>/day). Analyses of soil physicochemical properties demonstrated that soil redox-metastable components such as redox-active iron minerals and organic matter played a key role in storing electrons at high tide and shuttling electrons to infiltrated oxygen at low tide for ROS production. Our work sheds light on a ubiquitous but previously overlooked tidal source of ROS, which may accelerate carbon and metal cycles as well as pollutant degradation in coastal soils.
A primer on continuous-time modeling in educational research: an exemplary application of a continuous-time latent curve model with structured residuals (CT-LCM-SR) to PISA Data
2022-07-11

Abstract One major challenge of longitudinal data analysis is to find an appropriate statistical model that corresponds to the theory of change and the research questions at hand. In the present article, we argue that continuous-time models are well suited to study the continuously developing constructs of primary interest in the education sciences and outline key advantages of using this type of model. Furthermore, we propose the continuous-time latent curve model with structured residuals (CT-LCM-SR) as a suitable model for many research questions in the education sciences. The CT-LCM-SR combines growth and dynamic modeling and thus provides descriptions of both trends and process dynamics. We illustrate the application of the CT-LCM-SR with data from PISA reading literacy assessment of 2000 to 2018 and provide a tutorial and annotated code for setting up the CT-LCM-SR model.
Palynological investigations in the Orce Archaeological Zone, Early Pleistocene of Southern Spain
2022-07-11

Palynological investigations in the Orce Archaeological Zone (OAZ) (Guadix-Baza Basin, Granada, Spain), Venta Micena 1 (VM1), Barranco Leon (BL) and Fuente Nueva 3 (FN3) are presented. This archaeological region is con-nected with the first Homo populations in Western Eurasia during the Early Pleistocene. The VM1 pollen record is characterized by Ephedra, and to a lesser extent, Pinus, Juniperus and evergreen Quercus, occassionally accompa-nied by Olea, Genisteae, Erica, deciduous Quercus, Alnus, Castanea, Fraxinus, Salix and Phillyrea. BL is dominated by Juniperus, Olea, Pinus, Poaceae, and evergreen Quercus. FN3 is characterized by an open Mediterranean woodland dominated by evergreen Quercus, Pinus, Juniperus and Olea, accompanied by deciduous Quercus, Castanea, Populus, Salix, Ulmus, Fraxinus, Pistacia, Phillyrea, Genisteae, Erica, Cistus, and Ephedra fragilis. Relic Tertiary taxa in OAZ include Carya, Pterocarya, Eucommia, Zelkova, and Juglans. The Early Pleistocene OAZ vegetation is a mosaic of different landscapes embracing mesophytes, thermophytes, xerophytes, xerothermophytes, and Mediterra-nean elements. These finds are compared with former pollen analyses in the region and beyond within the Ibe-rian Peninsula. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Affective Empathy, Theory of Mind and Social Functioning in Patients With Focal Epilepsy
2022-07-11

Objective Social cognition comprises basic and more complex functions, such as theory of mind (ToM) and affective empathy. Although everyday social interactions may be impaired if such higher-order social cognitive functions are compromised, associations between social functioning and social cognition in people with focal epilepsy (PWFE) are still poorly understood. We used a novel, naturalistic approach to investigate ToM in PWFE by applying the Movie for the Assessment of Social Cognition (MASC). Furthermore, we studied affective empathy, the relationship between social cognitive parameters and measures of social functioning, as well as between epilepsy focus and ToM. Methods Thirty patients with either temporal (TLE) or frontal lobe epilepsy (FLE) were compared to 29 healthy control subjects (HC). In addition to the MASC, we applied questionnaire measures assessing empathy and everyday social functioning. Results PWFE, especially with FLE, performed significantly worse than HC on the MASC. Perceived social integration and social activities, but not affective empathy, were reduced in PWFE. Regression analyses revealed associations between perceived social integration, clinical group status, affective empathy and ToM. Conclusion PWFE displayed ToM deficits during a naturalistic task, whereas affective empathy was unimpaired. FLE may be associated with especially compromised ToM performance. Social cognition and social functioning appear to be interrelated in PWFE, whose self-perceived levels of social integration and social activities are lower than those of HC. More research into the association between social cognition and social functioning in PWFE is needed, in order to develop tailored intervention programs for these patients.
Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry
2022-07-11

Rare variants in at least 10 genes, including BRCA1, BRCA2, PALB2, ATM, and CHEK2, are associated with increased risk of breast cancer; however, these variants, in combination with common variants identified through genome-wide association studies, explain only a fraction of the familial aggregation of the disease. To identify further susceptibility genes, we performed a two-stage whole-exome sequencing study. In the discovery stage, samples from 1528 breast cancer cases enriched for breast cancer susceptibility and 3733 geographically matched unaffected controls were sequenced. Using five different filtering and gene prioritization strategies, 198 genes were selected for further validation. These genes, and a panel of 32 known or suspected breast cancer susceptibility genes, were assessed in a validation set of 6211 cases and 6019 controls for their association with risk of breast cancer overall, and by estrogen receptor (ER) disease subtypes, using gene burden tests applied to loss-of-function and rare missense variants. Twenty genes showed nominal evidence of association (p-value &lt; 0.05) with either overall or subtype-specific breast cancer. Our study had the statistical power to detect susceptibility genes with effect sizes similar to ATM, CHEK2, and PALB2, however, it was underpowered to identify genes in which susceptibility variants are rarer or confer smaller effect sizes. Larger sample sizes would be required in order to identify such genes.
The Perpetual Trouble with Network Products Why IT Firms Choose Partial Compatibility
2022-07-11

Abstract Compatibility of network products is an important issue in markets for communication technology as well as hard- and software products. Empirical findings suggest that firms competing in these markets typically choose intermediate degrees of product compatibility. We present a strategic two-stage game of two firms deciding independently or commonly on the degree of product compatibility in the first stage and on prices in the second stage. Indeed, partial compatibility constitutes a subgame perfect Nash equilibrium when coordination costs of standardization are high and the installed bases are low - conditions that typically characterize IT markets.
Effects of Information Load on Schema and Episodic Memory Formation
2022-07-11

The formation of semantic memories is assumed to result from the abstraction of general, schema-like knowledge across multiple experiences, while at the same time, episodic details from individual experiences are forgotten. Against this backdrop, our study examined the effects of information load (high vs. low) during encoding on the formation of episodic and schema memory using an elaborated version of an object-place recognition (OPR) task in rats. The task allowed for the abstraction of a spatial rule across four (low information load) or eight (high information load) encoding episodes (spaced apart by a 20 min interval) in which the rats could freely explore two objects in an open field arena. After this encoding phase, animals were left undisturbed for 24 h and then tested either for the expression of schema memory, i.e., for the spatial rule, or memory for an individual encoding episode. Rats in the high information load condition exhibited a more robust schema memory for the spatial rule than in the low information load condition. In contrast, rats in the low load condition showed more robust memory for individual learning episodes than in the high information load condition. Our findings of opposing effects might point to an information-load-dependent competitive relationship between processes of schema and episodic memory formation, although other explanations are possible.
Flares and rotation of M dwarfs with habitable zones accessible to TESS planet detections
2022-07-11

We characterize the magnetic activity of M dwarfs to provide the planet community with information on the energy input from the star; in particular, in addition to the frequency of optical flares directly observed with TESS, we aim at estimating the corresponding X-ray flare frequencies, making use of the small pool of known events observed simultaneously in both wavebands. We identified 112 M dwarfs with a TESS magnitude &lt;= 11.5 for which TESS can probe the full habitable zone for transits. These 112 stars have 1276 two-minute cadence TESS light curves from the primary mission, which we searched for rotational modulation and flares. We study the link between rotation and flares and between flare properties, for example the flare amplitude-duration relation and cumulative flare energy frequency distributions (FFDs). Assuming that each optical flare is associated with a flare in the X-ray band, and making use of published simultaneous Kepler/K2 and XMM-Newton flare studies, we estimate the X-ray energy released by our detected TESS flare events. Our calibration also involves the relation between flare energies in the TESS and K2 bands. We detected more than 2500 optical flare events on a fraction of about 32% of our targets and found reliable rotation periods only for 12 stars, which is a fraction of about 11%. For these 12 targets, we present cumulative FFDs and FFD power law fits. We construct FFDs in the X-ray band by calibrating optical flare energies to the X-rays. In the absence of directly observed X-ray FFDs for main-sequence stars, our predictions can serve for estimates of the high-energy input to the planet of a typical fast-rotating early- or mid-M dwarf.
Twenty-five Years at the Frontiers of Knowledge: A Quarter-century of “Frontiers in Bioscience”
2022-07-11

IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to making positive contributions to academics, corporate libraries as well as to readers and authors. All the editors in IMR Press will provide the best service for researchers, allowing them to have a easy and smooth publication experience and helping maximize the impact and visibility of their research.
Infrarenal abdominal aortic aneurysm repair: past, present and future or tempus rerum imperator
2022-07-11

Journal Article Infrarenal abdominal aortic aneurysm repair: past, present and future or tempus rerum imperator Get access Mario Lescan Mario Lescan Department of Thoracic and Cardiovascular Surgery, University Medical Centre Tübingen, Tübingen, Germany Corresponding author. Department of Thoracic and Cardiovascular Surgery, University Medical Centre Tübingen, Hoppe-Seyler Strasse 3, 72076 Tübingen, Germany. Tel: +49-7071-29-68192; fax: +49-7071-29-4047; e-mail: mario.lescan@med.uni-tuebingen.de (M. Lescan). https://orcid.org/0000-0002-3124-4994 Search for other works by this author on: Oxford Academic PubMed Google Scholar European Journal of Cardio-Thoracic Surgery, Volume 62, Issue 2, August 2022, ezac388, https://doi.org/10.1093/ejcts/ezac388 Published: 25 July 2022 Article history Received: 06 July 2022 Published: 25 July 2022 Corrected and typeset: 30 July 2022
Athena charged particle diverter simulations: effects of micro-roughness on proton scattering using Geant4
2022-07-11

The last generation of X-ray focusing telescopes operating outside the Earth's radiation belt discovered that optics were able to focus not only astrophysical X-ray photons, but also low-energy heliophysical protons entering the Field of View (FOV). This "soft proton" contamination affects around 40\\% of the observation time of XMM-Newton. The ATHENA Charged Particle Diverter (CPD) was designed to use magnetic fields to move these soft protons away from the FOV of the detectors, separating the background-contributing ions in the focused beam from the photons of interest. These magnetically deflected protons can hit other parts of the payload and scatter back to the focal plane instruments. Evaluating the impact of this secondary scattering with accurate simulations is essential for the CPD scientific assessment. However, while Geant4 simulations of grazing soft proton scattering on X-ray mirrors have been recently validated, the scattering on the unpolished surfaces of the payload (e.g. the baffle or the diverter itself) is still to be verified with experimental results. Moreover, the roughness structure can affect the energy and angle of the scattered protons, with a scattering efficiency depending on the specific target volume. Using Atomic Force Microscopy to take nanometer-scale surface roughness measurements from different materials and coating samples, we use Geant4 together with the CADMesh library to shoot protons at these very detailed surface roughness models to understand the effects of different material surface roughnesses, coatings, and compositions on proton energy deposition and scattering angles. We compare and validate the simulation results with laboratory experiments, and propose a framework for future proton scattering experiments.
Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe
2022-07-12

Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas in children/adolescents less than 18 years of age with an annual incidence of 1-2/million. Inter/intra-tumour heterogeneity raise challenges in clinical, pathological and biological research studies. Risk stratification in European and North American clinical trials previously relied on clinico-pathological features, but now, incorporates PAX3/7-FOXO1-fusion gene status in the place of alveolar histology. International working groups propose a coordinated approach through the INternational Soft Tissue SaRcoma ConsorTium to evaluate the specific genetic abnormalities and generate and integrate molecular and clinical data related to patients with RMS across different trial settings. We review relevant data and present a consensus view on what molecular features should be assessed. In particular, we recommend the assessment of the MYOD1-LR122R mutation for risk escalation, as it has been associated with poor outcomes in spindle/sclerosing RMS and rare RMS with classic embryonal histopathology. The prospective analyses of rare fusion genes beyond PAX3/7-FOXO1 will generate new data linked to outcomes and assessment of TP53 mutations and CDK4 amplification may confirm their prognostic value. Pathogenic/likely pathogenic germline variants in TP53 and other cancer predisposition genes should also be assessed. DNA/RNA profiling of tumours at diagnosis/relapse and serial analyses of plasma samples is recommended where possible to validate potential molecular biomarkers, identify new biomarkers and assess how liquid biopsy analyses can have the greatest benefit. Together with the development of new molecularly-derived therapeutic strategies that we review, a synchronised international approach is expected to enhance progress towards improved treatment assignment, management and outcomes for patients with RMS.
Chromosome-scale assembly and annotation of the perennial ryegrass genome
2022-07-12

Abstract Background The availability of chromosome-scale genome assemblies is fundamentally important to advance genetics and breeding in crops, as well as for evolutionary and comparative genomics. The improvement of long-read sequencing technologies and the advent of optical mapping and chromosome conformation capture technologies in the last few years, significantly promoted the development of chromosome-scale genome assemblies of model plants and crop species. In grasses, chromosome-scale genome assemblies recently became available for cultivated and wild species of the Triticeae subfamily. Development of state-of-the-art genomic resources in species of the Poeae subfamily, which includes important crops like fescues and ryegrasses, is lagging behind the progress in the cereal species. Results Here, we report a new chromosome-scale genome sequence assembly for perennial ryegrass, obtained by combining PacBio long-read sequencing, Illumina short-read polishing, BioNano optical mapping and Hi-C scaffolding. More than 90% of the total genome size of perennial ryegrass (approximately 2.55 Gb) is covered by seven pseudo-chromosomes that show high levels of collinearity to the orthologous chromosomes of Triticeae species. The transposon fraction of perennial ryegrass was found to be relatively low, approximately 35% of the total genome content, which is less than half of the genome repeat content of cultivated cereal species. We predicted 54,629 high-confidence gene models, 10,287 long non-coding RNAs and a total of 8,393 short non-coding RNAs in the perennial ryegrass genome. Conclusions The new reference genome sequence and annotation presented here are valuable resources for comparative genomic studies in grasses, as well as for breeding applications and will expedite the development of productive varieties in perennial ryegrass and related species.