julilili42/papers huggingface dataset:
Tübingen system in VarDial 2017 shared task: experiments with language identification and cross-lingual parsing
2017-01-01

This paper describes our systems and results on VarDial 2017 shared tasks. Besides three language/dialect discrimination tasks, we also participated in the cross-lingual dependency parsing (CLP) task using a simple methodology which we also briefly describe in this paper. For all the discrimination tasks, we used linear SVMs with character and word features. The system achieves competitive results among other systems in the shared task. We also report additional experiments with neural network models. The performance of neural network models was close but always below the corresponding SVM classifiers in the discrimination tasks. For the cross-lingual parsing task, we experimented with an approach based on automatically translating the source treebank to the target language, and training a parser on the translated treebank. We used off-the-shelf tools for both translation and parsing. Despite achieving better-than-baseline results, our scores in CLP tasks were substantially lower than the scores of the other participants.
Mechanisms of distinct activated carbon and biochar amendment effects on petroleum vapour biofiltration in soil
2017-01-01

We studied the effects of two percent by weight activated carbon<italic>versus</italic>biochar amendments in 93 cm long sand columns on the biofiltration of petroleum vapours released by a non-aqueous phase liquid (NAPL) source.
[Hyp-Au-Sn9(Hyp)3-Au-Sn9(Hyp)3-Au-Hyp]−: the longest intermetalloid chain compound of tin
2017-01-01

The reaction of the metalloid tin cluster [Sn<sub>10</sub>(Hyp)<sub>4</sub>]<sup>2−</sup>with (Ph<sub>3</sub>P)Au-SHyp (Hyp = Si(SiMe<sub>3</sub>)<sub>3</sub>) gave an intermetalloid cluster [Au<sub>3</sub>Sn<sub>18</sub>(Hyp)<sub>8</sub>]<sup>−</sup><bold>1</bold>, which is the longest intermetalloid chain compound of tin to date.
Fewer features perform well at Native Language Identification task
2017-01-01

This paper describes our results at the NLI shared task 2017. We participated in essays, speech, and fusion task that uses text, speech, and i-vectors for the task of identifying the native language of the given input. In the essay track, a linear SVM system using word bigrams and character 7-grams performed the best. In the speech track, an LDA classifier based only on i-vectors performed better than a combination system using text features from speech transcriptions and i-vectors. In the fusion task, we experimented with systems that used combination of i-vectors with higher order n-grams features, combination of i-vectors with word unigrams, a mean probability ensemble, and a stacked ensemble system. Our finding is that word unigrams in combination with i-vectors achieve higher score than systems trained with larger number of n-gram features. Our best-performing systems achieved F1-scores of 87.16%, 83.33% and 91.75% on the essay track, the speech track and the fusion track respectively.
Eye-Tracking as a Tool to Evaluate Functional Ability in Everyday Tasks in Glaucoma
2017-01-01

To date, few studies have investigated the eye movement patterns of individuals with glaucoma while they undertake everyday tasks in real-world settings. While some of these studies have reported possible compensatory gaze patterns in those with glaucoma who demonstrated good task performance despite their visual field loss, little is known about the complex interaction between field loss and visual scanning strategies and the impact on task performance and, consequently, on quality of life. We review existing approaches that have quantified the effect of glaucomatous visual field defects on the ability to undertake everyday activities through the use of eye movement analysis. Furthermore, we discuss current developments in eye-tracking technology and the potential for combining eye-tracking with virtual reality and advanced analytical approaches. Recent technological developments suggest that systems based on eye-tracking have the potential to assist individuals with glaucomatous loss to maintain or even improve their performance on everyday tasks and hence enhance their long-term quality of life. We discuss novel approaches for studying the visual search behavior of individuals with glaucoma that have the potential to assist individuals with glaucoma, through the use of personalized programs that take into consideration the individual characteristics of their remaining visual field and visual search behavior.
Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population
2017-01-01

Suboptimal fluid intake may require enhanced release of antidiuretic hormone (ADH) or vasopressin for the maintenance of adequate hydration. Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality. Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum- and glucocorticoid-inducible kinase 1 (SGK1). Moreover, dehydration upregulates the transcription factor NFAT5, which in turn stimulates SGK1 expression. SGK1 is activated by insulin, growth factors and oxidative stress via phosphatidylinositide-3-kinase, 3-phosphoinositide-dependent kinase PDK1 and mTOR. SGK1 is a powerful stimulator of Na&lt;sup&gt;+&lt;/sup&gt;/K&lt;sup&gt;+&lt;/sup&gt;-ATPase, carriers (e.g. the Na&lt;sup&gt;+&lt;/sup&gt;,K&lt;sup&gt;+&lt;/sup&gt;,2Cl&lt;sup&gt;-&lt;/sup&gt; cotransporter NKCC, the NaCl cotransporter NCC, the Na&lt;sup&gt;+&lt;/sup&gt;/H&lt;sup&gt;+&lt;/sup&gt; exchanger NHE3, and the Na&lt;sup&gt;+&lt;/sup&gt; coupled glucose transporter SGLT1), and ion channels (e.g. the epithelial Na&lt;sup&gt;+&lt;/sup&gt; channel ENaC, the Ca&lt;sup&gt;2+&lt;/sup&gt; release activated Ca&lt;sup&gt;2+&lt;/sup&gt; channel Orai1 with its stimulator STIM1, and diverse K&lt;sup&gt;+&lt;/sup&gt; channels). SGK1 further participates in the regulation of the transcription factors nuclear factor kappa-B NFκB, p53, cAMP responsive element binding protein (CREB), activator protein-1, and forkhead transcription factor FKHR-L1 (FOXO3a). Enhanced SGK1 activity fosters the development of hypertension, obesity, diabetes, thrombosis, stroke, inflammation including inflammatory bowel disease and autoimmune disease, cardiac fibrosis, proteinuria, renal failure as well as tumor growth. The present brief review makes the case that suboptimal fluid intake in the common population may enhance vasopressin and glucocorticoid levels thus up-regulating SGK1 expression and favouring the development of SGK1 related pathologies.
Spanish Adaptation of the Morningness-Eveningness-Stability-Scale improved (MESSi)
2017-01-01

Abstract The aim of the present study was to conduct the preliminary adaptation of the Morningness-Eveningness-Stability-Scale improved (MESSi) to Spanish population, testing its factor structure and construct validity. Participants were 261 adults (65% women; M = 31.4, SD = 12.01) who filled out measures of Morningness-Eveningness (MESSi and CSM), sleep habits, personality traits, positive and negative affect, and subjective level of alertness during the day. Psychometric results supported a three factorial model with the factors Morning Affect, Eveningness and Distinctness (RMSEA = .072). The factors showed good internal consistence (α = 0.72–0.85). The pattern of correlations between MESSi and the other measures were in the expected direction (low to moderated size effects). Morning Affect was positively predicted by morning chronotype ( R 2 = .64), Eveningness was negatively predicted by age and positively by evening chronotype ( R 2 = .41), and Distinctness was negatively predicted by sex (women reported higher DI than men) and age ( R 2 = .08). This study provides evidence for the factor structure of a new measure of Morningness-Eveningness based on a rigorous psychometric evaluation.
How to Morph Planar Graph Drawings
2017-01-01

Given an n-vertex graph and two straight-line planar drawings of the graph that have the same faces and the same outer face, we show that there is a morph (i.e., a continuous transformation) between the two drawings that preserves straight-line planarity and consists of O(n) steps, which we prove is optimal in the worst case. Each step is a unidirectional linear morph, which means that every vertex moves at constant speed along a straight line, and the lines are parallel although the vertex speeds may differ. Thus we provide an efficient version of Cairns’ 1944 proof of the existence of straight-line planarity-preserving morphs for triangulated graphs, which required an exponential number of steps.
Fitting Nonlinear Structural Equation Models in R with Package nlsem
2017-01-01

Fitting Nonlinear Structural Equation Models in R with Package nlsem&#13;\\nAbstract: \\tStructural equation mixture modeling (SEMM) has become a standard procedure in latent variable modeling over the last two decades (Jedidi, Jagpal, and DeSarbo 1997b; Muthén and Shedden 1999; Muthén 2001, 2004; Muthén and Asparouhov 2009). SEMM was proposed as a technique for the approximation of nonlinear latent variable relationships by finite mixtures of linear relationships (Bauer 2005, 2007; Bauer, Baldasaro, and Gottfredson 2012). In addition to this semiparametric approach to nonlinear latent variable modeling, there are numerous parametric nonlinear approaches for normally distributed variables (e.g., LMS in Mplus; Klein and Moosbrugger 2000). Recently, an additional semiparametric nonlinear structural equation mixture modeling (NSEMM) approach was proposed by Kelava, Nagengast, and Brandt (2014) that is capable of dealing with nonnormal predictors. In the nlsem package presented here, the SEMM, two distribution analytic (QML and LMS) and NSEMM approaches can be specified and estimated. We provide examples of how to use the package in the context of nonlinear latent variable modeling.
Cellular Effects of the Antiepileptic Drug Valproic Acid in Glioblastoma
2017-01-01

Background/Aims: Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug is used to treat epileptic seizure of glioblastoma patients. Besides its antiepileptic activity, VPA has been attributed further functions that improve the clinical outcome of glioblastoma patients. Those comprise the inhibition of some histone deacetylase (HDAC) isoforms which reportedly may result in radiosensitization. Retrospective analysis of patient data, however, could not unequivocally confirm a prolonged survival of glioblastoma patients receiving VPA. The present study aimed to identify potential VPA targets at the cellular level. Methods: To this end, the effect of VPA on metabolism, Ca2+-, biochemical and electro-signaling, cell-cycling, clonogenic survival and transfilter migration was analyzed in three human glioblastoma lines (T98G, U-87MG, U251) by MTT assay, Ca2+ imaging, immunoblotting, patch-clamp recording, flow cytometry, delayed plating colony formation and modified Boyden chamber assays, respectively. In addition, the effect of VPA on clonogenic survival of primary glioblastoma spheroid cultures treated with temozolomide and fractionated radiation was assessed by limited dilution assay. Results: In 2 of 3 glioblastoma lines, clinical relevant concentrations of VPA slightly slowed down cell cycle progression and decreased clonogenic survival. Furthermore, VPA induced Ca2+ signaling which was accompanied by pronounced K+ channel activity and transfilter cell migration. VPA did not affect metabolic NAD(P)H formation or radioresistance of the glioblastoma lines. Finally, VPA did not impair clonogenic survival or radioresistance of temozolomide-treated primary spheroid cultures. Conclusions: Combined, our in vitro data do not propose a general use of VPA as a radiosensitizer in anti-glioblastoma therapy.
Wannier functions and Z<sub>2</sub> invariants in time-reversal symmetric topological insulators
2017-01-01

We provide a constructive proof of exponentially localized Wannier functions and related Bloch frames in 1- and 2-dimensional time-reversal symmetric (TRS) topological insulators. The construction is formulated in terms of periodic TRS families of projectors (corresponding, in applications, to the eigenprojectors on an arbitrary number of relevant energy bands), and is thus model-independent. The possibility to enforce also a TRS constraint on the frame is investigated. This leads to a topological obstruction in dimension 2, related to topological phases. We review several proposals for indices that distinguish these topological phases, including the ones by Fu--Kane [Phys. Rev. B 74 (2006), 195312], Prodan [Phys. Rev. B 83 (2011), 235115], Graf--Porta [Commun. Math. Phys. 324 (2013), 851] and Fiorenza--Monaco--Panati [Commun. Math. Phys., in press]. We show that all these formulations are equivalent. In particular, this allows to prove a geometric formula for the the invariant of 2-dimensional TRS topological insulators, originally indicated in [Phys. Rev. B 74 (2006), 195312], which expresses it in terms of the Berry connection and the Berry curvature.
Gastric Ulcer Complications after the Introduction of Proton Pump Inhibitors into Clinical Routine: 20-Year Experience
2017-01-01

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The aim of this study was to analyze the admissions and the management of peptic ulcer disease (PUD) in a tertiary care surgical center. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We evaluated the medical records of all patients admitted to the University Hospital of Tübingen, Germany, for treatment of PUD during 1989-2008. Patients were included into the study if the diagnosis was verified endoscopically or surgically. Annual number of admissions, length of hospitalization, mortality rate, age, rate of non-steroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitor (PPI) medication, rate of &lt;i&gt;Helicobacter pylori&lt;/i&gt; infection, and complications of PUD and surgery performed were recorded. Data were analyzed by descriptive analyses, Pearson's chi-square test, and regression analysis. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; This study included 614 admissions. The number of annual admissions (31 ± 12), the length of hospitalization (9 ± 3 days), and the mortality rate (5 ± 4% per year) remained constant, whereas the age increased (1989: 52 ± 14 years vs. 2008: 67 ± 16 years). The rates of patients with &lt;i&gt;H. pylori&lt;/i&gt; infection (47 ± 28% per year), NSAIDs treatment (29 ± 15% per year), and PPI treatment (31 ± 27% per year) remained constant. The most frequent PUD complication was hemorrhage (42 ± 16% per year), followed by perforation (9 ± 8% per year). During 1999-2008, more hemorrhages (125 vs. 121; p &lt; 0.05) and perforations (40 vs. 21; p &lt; 0.05) were registered than during 1989-1998. The rate of emergency surgery increased from 70% during 1989-1998 to 87% during 1999-2008. In contrast, elective surgery decreased from 21% during 1989-1998 to 7% during 1999-2008. Ulcer excision and oversewing was the most frequent surgical procedure performed (59%), with decreasing rates of acid-reducing surgery. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Despite recent advances in PUD management, ulcer hemorrhage and perforation remain a significant health burden and a surgical disease.
Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis
2017-01-01

Background . Infection with Coxsackievirus B3 induces myocarditis. We aimed to compare the acute and chronic phases of viral myocarditis to identify the immediate effects of cardiac inflammation as well as the long-term effects after resolved inflammation on cardiac fibrosis and consequently on cardiac function. Material and Methods . We infected C57BL/6J mice with Coxsackievirus B3 and determined the hemodynamic function 7 as well as 28 days after infection. Subsequently, we analyzed viral burden and viral replication in the cardiac tissue as well as the expression of cytokines and matrix proteins. Furthermore, cardiac fibroblasts were infected with virus to investigate if viral infection alone induces profibrotic signaling. Results . Severe cardiac inflammation was determined and cardiac fibrosis was consistently colocalized with inflammation during the acute phase of myocarditis. Declined cardiac inflammation but no significantly improved hemodynamic function was observed 28 days after infection. Interestingly, cardiac fibrosis declined to basal levels as well. Both cardiac inflammation and fibrosis were reversible, whereas the hemodynamic function remains impaired after healed viral myocarditis in C57BL/6J mice.
SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice
2017-01-01

Background: Cellular glucose uptake may involve either non-concentrative glucose carriers of the GLUT family or Na+-coupled glucose-carrier SGLT1, which accumulates glucose against glucose gradients and may thus accomplish cellular glucose uptake even at dramatically decreased extracellular glucose concentrations. SGLT1 is not only expressed in epithelia but as well in tumour cells and immune cells. Immune cell functions strongly depend on their metabolism, therefore we hypothesized that deficiency of SGLT1 modulates the defence against bacterial infection. To test this hypothesis, we infected wild type mice and gene targeted mice lacking functional SGLT1 with Listeria monocytogenes. Methods: SGLT1 deficient mice and wild type littermates were infected with 1x104 CFU Listeria monocytogenes intravenously. Bacterial titers were determined by colony forming assay, SGLT1, TNF-α, IL-6 and IL-12a transcript levels were determined by qRT-PCR, as well as SGLT1 protein abundance and localization by immunohistochemistry. Results: Genetic knockout of SGLT1 (Slc5a1–/– mice) significantly compromised bacterial clearance following Listeria monocytogenes infection with significantly enhanced bacterial load in liver, spleen, kidney and lung, and significantly augmented hepatic expression of TNF-α and IL-12a. While all wild type mice survived, all SGLT1 deficient mice died from the infection. Conclusions: SGLT1 is required for bacterial clearance and host survival following murine Listeria infection.
Neurons, Erythrocytes and Beyond –The Diverse Functions of Chorein
2017-01-01

Chorea-acanthocytosis (ChAc), a neurodegenerative disease, results from loss-of-function-mutations of the chorein-encoding gene VPS13A. Affected patients suffer from a progressive movement disorder including chorea, parkinsonism, dystonia, tongue protrusion, dysarthria, dysphagia, tongue and lip biting, gait impairment, progressive distal muscle wasting, weakness, epileptic seizures, cognitive impairment, and behavioral changes. Those pathologies may be paralleled by erythrocyte acanthocytosis. Chorein supports activation of phosphoinositide-3-kinase (PI3K)-p85-subunit with subsequent up-regulation of ras-related C3 botulinum toxin substrate 1 (Rac1) activity, p21 protein-activated kinase 1 (PAK1) phosphorylation, and activation of several tyrosine kinases. Chorein sensitive PI3K signaling further leads to stimulation of the serum and glucocorticoid inducible kinase SGK1, which in turn upregulates ORAI1, a Ca2+-channel accomplishing store operated Ca2+-entry (SOCE). The signaling participates in the regulation of cytoskeletal architecture on the one side and cell survival on the other. Compromised cytoskeletal architecture has been shown in chorein deficient erythrocytes, fibroblasts and endothelial cells. Impaired degranulation was observed in chorein deficient PC12 cells and in platelets from ChAc patients. Similarly, decreased ORAI1 expression and SOCE as well as compromised cell survival were seen in fibroblasts and neurons isolated from ChAc patients. ORAI1 expression, SOCE and cell survival can be restored by lithium treatment, an effect disrupted by pharmacological inhibition of SGK1 or ORAI1. Chorein, SGK1, ORAI1 and SOCE further confer survival of tumor cells. In conclusion, much has been learned about the function of chorein and the molecular pathophysiology of chorea-acanthocytosis. Most importantly, a treatment halting or delaying the clinical course of this devastating disease may become available. A controlled clinical study is warranted, in order to explore whether the in vitro observations indeed reflect the in vivo pathology of the disease.
Stimulation of Erythrocyte Cell Membrane Scrambling by C-Reactive Protein
2017-01-01

Background: Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine-translocation, is triggered by fever and inflammation. Signaling includes increased cytosolic Ca2+-activity ([Ca2+]i), caspase activation, and ceramide. Inflammation is associated with increased plasma concentration of C-reactive protein (CRP). The present study explored whether CRP triggers eryptosis. Methods: Phosphatidylserine abundance at the cell surface was estimated from annexin-V-binding, cell volume from forward scatter, [Ca2+]i from Fluo3-fluorescence, ceramide abundance and caspase-3-activity utilizing FITC-conjugated antibodies. Moreover, blood was drawn from patients with acute appendicitis (9♀,11♂) and healthy volunteers (10♀,10♂) for determination of CRP, blood count and phosphatidylserine. Results: A 48h CRP treatment significantly increased the percentage of annexin-V-binding cells (≥5μg/ml), [Ca2+]i (≥5μg/ml), ceramide (20μg/ml) and caspase-activity (20μg/ml). Annexin-V-binding was significantly blunted by caspase inhibitor zVAD (10μM). The percentage of phosphatidylserine-exposing erythrocytes in freshly drawn blood was significantly higher in appendicitis patients (1.83±0.21%) than healthy volunteers (0.81±0.09%), and significantly higher following a 24h incubation of erythrocytes from healthy volunteers to patient plasma than to plasma from healthy volunteers. The percentage of phosphatidylserine-exposing erythrocytes correlated with CRP plasma concentration. Conclusion: C-reactive protein triggers eryptosis, an effect at least partially due to increase of [Ca2+]i, increase of ceramide abundance and caspase activation.
Evaluation of a Pilot Project to Introduce Simulation-Based Team Training to Pediatric Surgery Trauma Room Care
2017-01-01

Introduction . Several studies in pediatric trauma care have demonstrated substantial deficits in both prehospital and emergency department management. Methods . In February 2015 the PAEDSIM collaborative conducted a one and a half day interdisciplinary, simulation based team-training course in a simulated pediatric emergency department. 14 physicians from the medical fields of pediatric surgery, pediatric intensive care and emergency medicine, and anesthesia participated, as well as four pediatric nurses. After a theoretical introduction and familiarization with the simulator, course attendees alternately participated in six simulation scenarios and debriefings. Each scenario incorporated elements of pediatric trauma management as well as Crew Resource Management (CRM) educational objectives. Participants completed anonymous pre- and postcourse questionnaires and rated the course itself as well as their own medical qualification and knowledge of CRM. Results . Participants found the course very realistic and selected scenarios highly relevant to their daily work. They reported a feeling of improved medical and nontechnical skills as well as no uncomfortable feeling during scenarios or debriefings. Conclusion . To our knowledge this pilot-project represents the first successful implementation of a simulation-based team-training course focused on pediatric trauma care in German-speaking countries with good acceptance.