1174 CARCINOMA IN SITU (CIS) AND MUSCLE INVASIVE BLADDER CANCER ARE MORE COMMON IN WOMEN: THE ANALYSIS OF 600 PRIMARY CASES AT INITIAL PRESENTATION
2010-03-23

You have accessJournal of UrologyBladder Cancer: Detection and Screening1 Apr 20101174 CARCINOMA IN SITU (CIS) AND MUSCLE INVASIVE BLADDER CANCER ARE MORE COMMON IN WOMEN: THE ANALYSIS OF 600 PRIMARY CASES AT INITIAL PRESENTATION Stephan Kruck, Maximilian Burger, Stefan Denzinger, Joerg Hennenlotter, Wolfgang Otto, Arndt Hartmann, Falko Fend, Wolf F. Wieland, Arnulf Stenzl, and Karl-Dietrich Sievert Stephan KruckStephan Kruck Tuebingen, Germany More articles by this author , Maximilian BurgerMaximilian Burger Regensburg, Germany More articles by this author , Stefan DenzingerStefan Denzinger Regensburg, Germany More articles by this author , Joerg HennenlotterJoerg Hennenlotter Tuebingen, Germany More articles by this author , Wolfgang OttoWolfgang Otto Regensburg, Germany More articles by this author , Arndt HartmannArndt Hartmann Erlangen, Germany More articles by this author , Falko FendFalko Fend Tuebingen, Germany More articles by this author , Wolf F. WielandWolf F. Wieland Regensburg, Germany More articles by this author , Arnulf StenzlArnulf Stenzl Tuebingen, Germany More articles by this author , and Karl-Dietrich SievertKarl-Dietrich Sievert Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.674AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Bladder cancer is significantly more frequent in males than in females, which is primarily explained by the greater exposure to respective carcinogenic influences in men, however, it has been frequently reported that the cancer-specific outcome is significantly adverse in female vs. male patients. While this outcome has been attributed to socioeconomic factors and worse tumor cancer biologies unrelated to carcinogens, no distinct analysis of the tumor stage at initial presentation has been reported to date. Aim of the present contribution was to clarify if women tend to initially present with adverse tumor stages that might contribute to poorer outcome opposed to men. METHODS All primary bladder cancer patients without prior history of urothelial neoplasia that initially presented to the Departments of Urology at the Universities of Regensburg (R) and Tuebingen (T) in Germany were enrolled. A recent time period of four years was chosen for better comparability of TUR technique and histopathological evaluation. Photodynamic diagnostics-assisted TUR were performed in the majority of cases; the current WHO classification was used in all cases. RESULTS Between 01/2005 and 01/2009 n=604 (160 female; 444 male) primary bladder cancers presented at R (255) and T (349), respectively. There were no differences in any characteristics between the R and T series. Initial muscle invasive stages (≥pT2) were found in 26% of female and 20% of male patients, respectively (p=0.036). Overall CIS was found in 16% of female and 13% male patients, respectively (p=0.067). CIS only or in association with non-muscle invasive stages was found in 12% of female and 10% of male patients, respectively (p= 0.095). CONCLUSIONS In this series, the incidence rate of initial CIS tends to be higher in women with a significantly greater proportion of women presenting with advanced muscle invasive bladder tumor stages thus contributing to the poorer outcome in women as opposed to men. While women overall are less likely to develop bladder cancer, the women who do, require intense urological attention and accordingly its respective awareness should be raised. Further studies in larger series on more selective issues, such as molecular parameters, are warranted. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e455 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stephan Kruck Tuebingen, Germany More articles by this author Maximilian Burger Regensburg, Germany More articles by this author Stefan Denzinger Regensburg, Germany More articles by this author Joerg Hennenlotter Tuebingen, Germany More articles by this author Wolfgang Otto Regensburg, Germany More articles by this author Arndt Hartmann Erlangen, Germany More articles by this author Falko Fend Tuebingen, Germany More articles by this author Wolf F. Wieland Regensburg, Germany More articles by this author Arnulf Stenzl Tuebingen, Germany More articles by this author Karl-Dietrich Sievert Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...