julilili42/papers huggingface dataset:
Cognitive control in cross-modal contexts: Abstract feature transitions of task-related but not task-unrelated stimuli modulate the congruency sequence effect.
2023-10-26

Context information can guide cognitive control, but both the extent and the underlying processes are poorly understood. Previous studies often found that the congruency sequence effect (CSE) is larger when perceptual context features (e.g., modality and format) of task-related distractors and targets repeat compared to change. However, it is unclear whether control adjustments can also be contextualized by more abstract stimulus features and/or by features of task-unrelated stimuli. The present study addressed this issue using a novel context manipulation in a confound-minimized prime-probe task. In Experiment (Exp.) 1, the modality (visual and auditory) of the distractor and target either repeated or changed. Critically, in Exp. 2, the distractor and target modality always switched, but the cross-modal intensity (brightness and loudness) could either repeat (e.g., bright → loud) or change (e.g., bright → soft). A larger CSE for context repeats (vs. changes) was observed in Exps. 1 and 2, indicating that both concrete (modality) and abstract stimulus features (cross-modal intensity) can contextualize control adjustments. Exps. 3 and 4 demonstrated that the CSE was not reliably affected when the context manipulation concerned a prior signal or a simultaneous background stimulus. Thus, task-related, but not task-unrelated, concrete and abstract stimulus features contextualize control adjustments. Moreover, distributional (delta plot) analyses of present and previous data revealed that the confound-minimized CSE and its contextual modulation reflect adjustments in the strength of cognitive control rather than in its timing. Overall, the present study provides new insights into how context information interacts with cognitive control to optimize decision making under conflict. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Error Analysis for 2D Stochastic Navier–Stokes Equations in Bounded Domains with Dirichlet Data
2023-10-26

Abstract We study a finite-element based space-time discretisation for the 2D stochastic Navier–Stokes equations in a bounded domain supplemented with no-slip boundary conditions. We prove optimal convergence rates in the energy norm with respect to convergence in probability, that is convergence of order (almost) 1/2 in time and 1 in space. This was previously only known in the space-periodic case, where higher order energy estimates for any given (deterministic) time are available. In contrast to this, estimates in the Dirichlet-case are only known for a (possibly large) stopping time. We overcome this problem by introducing an approach based on discrete stopping times. This replaces the localised estimates (with respect to the sample space) from earlier contributions.
Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2
2023-10-26

The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. By inhibiting the Raf/MEK/ERK signaling pathway, a central kinase cascade of eukaryotic cells, which is being exploited by numerous viruses of different virus phyla, the small-molecule MEK inhibitor zapnometinib has the potential to address this need. We here performed a side-by-side comparison of the antiviral efficacy of zapnometinib against IAV and SARS-CoV-2 to determine the concentration leading to 50% of its effect on the virus (EC 50 ) and the concentration leading to 50% reduction of ERK phosphorylation (IC 50 ) in a comparable manner, using the same experimental conditions. Our results show that the EC 50 value and IC 50 value of zapnometinib are indeed lower for IAV compared to SARS-CoV-2 using one representative strain for each. The results suggest that IAV’s replication has a stronger dependency on an active Raf/MEK/ERK pathway and, thus, that IAV is more susceptible to treatment with zapnometinib than SARS-CoV-2. With zapnometinib’s favorable outcome in a recent phase II clinical trial in hospitalized COVID-19 patients, the present results are even more promising for an upcoming phase II clinical trial in severe influenza virus infection.
Numerical Representation for Action in Crows Obeys the Weber-Fechner Law
2023-10-26

The psychophysical laws governing the judgment of perceived numbers of objects or events, called the number sense, have been studied in detail. However, the behavioral principles of equally important numerical representations for action are largely unexplored in both humans and animals. We trained two male carrion crows ( Corvus corone) to judge numerical values of instruction stimuli from one to five and to flexibly perform a matching number of pecks. Our quantitative analysis of the crows’ number production performance shows the same behavioral regularities that have previously been demonstrated for the judgment of sensory numerosity, such as the numerical distance effect, the numerical magnitude effect, and the logarithmical compression of the number line. The presence of these psychophysical phenomena in crows producing number of pecks suggests a unified sensorimotor number representation system underlying the judgment of the number of external stimuli and internally generated actions.
Not Equivalent (Yet?): The Current EU Third Country Regime for Credit Institutions and Incoming Changes
2023-10-26

Abstract As part of the European Commission’s ‘Banking Package’, introducing a series of amendments to the key legal sources of EU banking regulation, a comprehensive proposal for the treatment of third country branches of credit institutions (i.e., branches of institutions licensed by non-EU jurisdictions seeking authorisation in an EU Member State) has been presented. If and when ultimately adopted, this new framework will, for the first time, harmonise the applicable authorisation procedures and substantive conditions for authorisation hitherto left exclusively to the discretion of EU Member States. Under the new regime, the equivalence of third country regulatory and supervisory approaches with EU banking regulation will play a role, albeit a limited one. While taking up, and refining, approaches that have been present in a range of Member States for some time already, the new framework will require others to fundamentally change their existing regimes. The new amendments will be of particular relevance for the future regulatory relationship between the United Kingdom and the European Union, since a bespoke arrangement for continuing access of UK financial intermediaries to the EU markets has not been achieved, and UK credit institutions wishing to continue to operate within the EU other than through legally separate and independently capitalised subsidiaries have to rely on authorisations as third country branches. Against this backdrop, the present paper presents a functional analysis of the incoming regime in light of experiences made with regard to the existing landscape of diverging national laws.
Learning by Teaching in the Wild: Domain, Grades, and School Track Matter
2023-10-26

The use of evidence-based practice can be regarded as the gold standard in education. A steadily adopted educational practice is non-interactive teaching, in which students explain the previously learned contents to a fictitious peer. Although recent laboratory studies documented the benefits of non-interactive teaching, field-oriented evidence is scarce regarding different implementations, contents, student populations, and domains. In this field study, we applied the ManyClasses approach to test the generalizability of non-interactive teaching in diverse contexts to explore external boundary conditions (domain, school type, grading, medium and timing of the learning task) and student-related boundary conditions (age, gender, native language). We examined the effect of non-interactive teaching in k = 20 different teaching units (each 2 lessons) across various school types and subjects in which school students (N = 191) were randomly assigned to sequences of non-interactive teaching and retrieval practice (within-participants design). We did not obtain a main effect of non-interactive teaching; but the domain, school type, and grading moderated the effectiveness of teaching. The findings demonstrated the feasibility of the ManyClasses approach and highlighted the need of considering contextual variables to make generalizable recommendations for educational practice at the same time.
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
2023-10-26

SUMMARY Several viruses hijack various forms of endocytosis in order to infect host cells. Here, we report the discovery of a new molecule with antiviral properties that we named virapinib, which limits viral entry by macropinocytosis. The identification of virapinib derives from a chemical screen using High-Throughput Microscopy, where we identified new chemical entities capable of preventing infection with a pseudotype virus expressing the spike (S) protein from SARS-CoV-2. Subsequent experiments confirmed the capacity of virapinib to inhibit infection by SARS-CoV-2, as well as by additional viruses, such as Monkeypox virus and TBEV. Mechanistic analyses revealed that the compound inhibited macropinocytosis, limiting this entry route for the viruses. Importantly, virapinib has no significant toxicity to host cells. In summary, we present a new molecule that inhibits viral entry via the endocytic route, offering a new alternative to prevent viral infection.
ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING
2023-10-26

Abstract New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro . The development of high-throughput approaches for the screening of such inhibitors could accelerate their identification, testing, and implementation, and thus holds exciting potential for improving the treatments and outcomes of snakebite envenomation worldwide. Energetics-based proteomic approaches, including Thermal Proteome Profiling (TPP) and Proteome Integral Solubility Alteration (PISA), assays represent “deep proteomics” methods for high throughput, proteome-wide identification of drug targets and ligands. In the following study, we apply TPP and PISA methods to characterize the interactions between venom toxin proteoforms in Crotalus atrox (Western Diamondback Rattlesnake) and the snake venom metalloprotease (SVMP) inhibitor marimastat. We investigate its venom proteome-wide effects and characterize its interactions with specific SVMP proteoforms, as well as its potential targeting of non-SVMP venom toxin families. We also compare the performance of PISA thermal window and soluble supernatant with insoluble precipitate using two inhibitor concentrations, providing the first demonstration of the utility of a sensitive high-throughput PISA-based approach to assess the direct targets of small molecule inhibitors for snake venom.
Comment on egusphere-2023-1904
2023-10-26

<strong class="journal-contentHeaderColor">Abstract.</strong> We investigate the lock-in zone (LIZ) of the EastGRIP region, Northeast Greenland, in detail. We present results from the firn air pumping campaign of the S6 borehole, forward modeling, and a novel technique for finding the lock-in depth (LID, the top of the LIZ) based on the visual stratigraphy of the EastGRIP ice core. The findings in this work help to deepen our knowledge of how atmospheric gases are trapped in ice cores. <em>CO</em><sub>2</sub>, <em>&delta;</em><sup>15</sup><em>N</em>, and <em>CH</em><sub>4</sub> data suggest the LID lies around 58 to 61 m depth. With the grayscale and bright spot analysis based on visual stratigraphy, we can pinpoint a change in ice properties to exactly 58.3 m depth, which we define as the optical lock-in depth (OLID). This visual change in ice properties is caused by the formation of rounded and enclosed air bubbles, altering the measured refraction of the light pathways. The results for the LID and OLID agree accurately on the depth. We furthermore use the visual stratigraphy images to obtain information on the sharpness of the open to closed porosity transition. Combing traditional methods with the independent optical method presented here, we can now better constrain the bubble closure processes in polar firn.
Uni TÜ_NP_Library_POS_mzml
2023-10-26

&amp;lt;p&amp;gt;Q Hexactive HF. 17 Pools of pure NPs analzyed by Giovanni Andrea Vitale and Christian Geibel from Petras Lab. mode= positive DDA, stepped CE (25, 35, 45), Res MS1= 30K, MS2=15k Fragment= Top 5 ions&amp;lt;/p&amp;gt;
The Influence of Sex, Age, and Race on Coronary Artery Disease: A Narrative Review
2023-10-27

Cardiovascular disease has remained one of the leading causes of mortality in the world. The basic pathophysiology of coronary artery disease (CAD) is a reduction of the blood flow in coronary vessels, leading to restricted blood flow to the heart muscle. Both modifiable and non-modifiable risk factors contribute to its multifactorial etiology. The clinical presentation ranges from asymptomatic to typical symptoms like chest pain, shortness of breath, and left arm or jaw pain. The purpose of this review is to investigate and analyze the variation of CAD depending on the biological sex, age, race, or ethnicity and how it might differ in the studied population while comparing the symptoms and prognosis of CAD. For this research, PubMed's database was used. A total of 926 articles were selected using pre-determined inclusion and exclusion criteria, with 74 articles eligible to be included in the narrative review. Studies were selected from the general population of patients with CAD, regardless of their severity, stage of diagnosis, and treatment plan. The scale for the assessment of non-systematic review articles (SANRA) was used to assess the quality of the study. As humans age, the incidence of CAD increases, and people over 75 are more likely to have multiple-vessel CAD. It has been observed that South Asians have the highest rate of CAD at 24%, while the White population has the lowest at 8%. The prevalence of CAD also depends on race, with the White population having the lowest rate at 3.2%, followed by Hispanics at 5%, Black women at 5.2%, and Black men at 5.7%. Younger Black women tend to have more chest pain. Men with CAD commonly experience chest pain, and women are more likely to present with atypical symptoms. Modifiable risk factors such as smoking and alcoholism are more commonly observed in young men than in young women. Coronary artery disease in the elderly, female, minority, and Black patients is associated with a higher mortality rate. Acknowledging the prevalence of certain risk factors, signs, results, and responses to treatment in certain socio-demographic groups, as well as the provision and accessibility of diagnosis and treatment, would lead to a better outcome for all individuals. The impact of this shift can range from an earlier diagnosis of CAD to a faster and more customized treatment plan tailored to each patient's individual requirements.
Magnetic Structures and Turbulence in SN 1006 Revealed with Imaging X-Ray Polarimetry
2023-10-27

Abstract Young supernova remnants strongly modify the surrounding magnetic fields, which in turn play an essential role in accelerating cosmic rays (CRs). The X-ray polarization measurements probe magnetic field morphology and turbulence at the immediate acceleration site. We report the X-ray polarization distribution in the northeastern shell of SN 1006 from a 1 Ms observation with the Imaging X-ray Polarimetry Explorer. We found an average polarization degree of 22.4% ± 3.5% and an average polarization angle of −45.°4 ± 4.°5 (measured on the plane of the sky from north to east). The X-ray polarization angle distribution reveals that the magnetic fields immediately behind the shock in the northeastern shell of SN 1006 are nearly parallel to the shock normal or radially distributed, similar to that in the radio observations, and consistent with the quasi-parallel CR acceleration scenario. The X-ray emission is marginally more polarized than that in the radio band. The X-ray polarization degree of SN 1006 is much larger than that in Cas A and Tycho, together with the relatively tenuous and smooth ambient medium of the remnant, favoring that CR-induced instabilities set the magnetic turbulence in SN 1006, and CR acceleration is environment-dependent.
Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus
2023-10-27

Introduction Most childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The prognosis of children with LN and end-stage renal disease is particularly dire. Mortality rates within the first five years of renal replacement therapy may reach 22%. Thus, there is urgent need to decipher and target immune mechanisms that drive cLN. Despite the clear role of autoantibody production in SLE, targeted B cell therapies such as rituximab (anti-CD20) and belimumab (anti-BAFF) have shown only modest efficacy in cLN. While many studies have linked dysregulation of germinal center formation to SLE pathogenesis, other work supports a role for extrafollicular B cell activation in generation of pathogenic antibody secreting cells. However, whether extrafollicular B cell subsets and their T cell collaborators play a role in specific organ involvement in cLN and/or track with disease activity remains unknown. Methods We analyzed high-dimensional mass cytometry and gene expression data from 24 treatment naïve cSLE patients at the time of diagnosis and longitudinally, applying novel computational tools to identify abnormalities associated with clinical manifestations (cLN) and disease activity (SLEDAI). Results cSLE patients have an extrafollicular B cell expansion signature, with increased frequency of i) DN2, ii) Bnd2, iii) plasmablasts, and iv) peripheral T helper cells. Most importantly, we discovered that this extrafollicular signature correlates with disease activity in cLN, supporting extrafollicular T/B interactions as a mechanism underlying pediatric renal pathogenesis. Discussion This study integrates established and emerging themes of extrafollicular B cell involvement in SLE by providing evidence for extrafollicular B and peripheral T helper cell expansion, along with elevated type 1 IFN activation, in a homogeneous cohort of treatment-naïve cSLE patients, a point at which they should display the most extreme state of their immune dysregulation.
Anxiety associated with perceived uncontrollable stress enhances expectations of environmental volatility and impairs reward learning
2023-10-27

Abstract Unavoidable stress can lead to perceived lack of control and learned helplessness, a risk factor for depression. Avoiding punishment and gaining rewards involve updating the values of actions based on experience. Such updating is however useful only if action values are sufficiently stable, something that a lack of control may impair. We examined whether self-reported stress uncontrollability during the first wave of the COVID-19 pandemic predicted impaired reward-learning. In a preregistered study during the first-wave of the COVID-19 pandemic, we used self-reported measures of depression, anxiety, uncontrollable stress, and COVID-19 risk from 427 online participants to predict performance in a three-armed-bandit probabilistic reward learning task. As hypothesised, uncontrollable stress predicted impaired learning, and a greater proportion of probabilistic errors following negative feedback for correct choices, an effect mediated by state anxiety. A parameter from the best-fitting hidden Markov model that estimates expected beliefs that the identity of the optimal choice will shift across images, mediated effects of state anxiety on probabilistic errors and learning deficits. Our findings show that following uncontrollable stress, anxiety promotes an overly volatile representation of the reward-structure of uncertain environments, impairing reward attainment, which is a potential path to anhedonia in depression.
Identification of MicroRNAs Associated with Prediabetic Status in Obese Women
2023-10-27

MicroRNAs (miRNAs) recently emerged as means of communication between insulin-sensitive tissues to mediate diabetes development and progression, and as such they present a valuable proxy for epigenetic alterations associated with type 2 diabetes. In order to identify miRNA markers for the precursor of diabetes called prediabetes, we applied a translational approach encompassing analysis of human plasma samples, mouse tissues and an in vitro validation system. MiR-652-3p, miR-877-5p, miR-93-5p, miR-130a-3p, miR-152-3p and let-7i-5p were increased in plasma of women with impaired fasting glucose levels (IFG) compared to those with normal fasting glucose and normal glucose tolerance (NGT). Among these, let-7i-5p and miR-93-5p correlated with fasting blood glucose levels. Human data were then compared to miRNome data obtained from islets of Langerhans and adipose tissue of 10-week-old female New Zealand Obese mice, which differ in their degree of hyperglycemia and liver fat content. Similar to human plasma, let-7i-5p was increased in adipose tissue and islets of Langerhans of diabetes-prone mice. As predicted by the in silico analysis, overexpression of let-7i-5p in the rat β-cell line INS-1 832/12 resulted in downregulation of insulin signaling pathway components (Insr, Rictor, Prkcb, Clock, Sos1 and Kcnma1). Taken together, our integrated approach highlighted let-7i-5p as a potential regulator of whole-body insulin sensitivity and a novel marker of prediabetes in women.
Demand-oriented design of telemedical services in gynecologic oncology
2023-10-27

Abstract Background The medical field is in the midst of a massive expansion in telemedical services. However, it is not possible to say to what extent telemedical offerings can be designed to meet needs in the German healthcare system. This study provides insights into demand-oriented care using telemedical services for gynecological patients. Methods A total of 262 patients who received systemic therapy for gynecological oncology were surveyed anonymously using a questionnaire regarding their acceptance of telemedicine from February 2021 to April 2021. Results Insufficient computer skills were associated with less acceptance of telemedicine treatment by gynecological oncology patients and presented a barrier. However, the patient’s level of education was not related to the level of acceptance. Long travel distances from medical facilities and some types of patient occupations significantly increased the acceptance of telemedicine services. A high level of education, on the other hand, was not associated with the approval of telemedical approaches. Long journeys and work commitments increased the acceptance of telemedical visits. Conclusions The results of this study show that the factors investigated have an influence on the acceptance of telemedical offerings by patients. Barriers such as insufficient computer skills must be taken into account when implementing telemedicine services. Telemedicine can provide physical and economic relief for patients if telemedical planning is tailored to their needs.