julilili42/papers huggingface dataset:
An alternative illumination source based on LEDs for PIV measurements on human swimmers—A feasibility study
2022-10-12

Methods for flow visualization help to investigate the motion of fluids that are normally invisible. Especially, Particle Image Velocimetry (PIV) – with a laser as light source – has been established in the field of engineering and partly in biology. Since the standard measuring equipment applying a laser system is very sensitive with respect to transport, temperature, humidity as well as laser safety requirements have to be adhered, the observation and classification of flow pattern around human swimmers in swimming pools has been rarely applied. There is a need for a simple, powerful, affordable, robust, and portable illumination source which shall not harm the swimmer by exceeding the permitted maximum radiation for human skin and eyes. As a result, this technical note demonstrates an alternative light source system based on LEDs which enables PIV measurements around human swimmers similar to experiments with a (traditional) laser system. As an example, the flow fields of two different swimmers with a similar movement and phase are compared using both illumination methods laser and LED. Furthermore, a series of sequential velocity fields, produced by the motion of a monofin swimmer, generate a vortex pair with an inverse Karman vortex street which is typically seen in fish and marine mammal locomotion. Consequently, this LED illumination source is show to provide a sufficient suitable light intensity as well as light quality enabling the measurement of the flow field around swimmers.
Neural correlates of affective task switching and asymmetric affective task switching costs
2022-10-12

Abstract The control of emotions is of potentially great clinical relevance. Accordingly, there has been increasing interest in understanding the cognitive mechanisms underlying the ability to switch efficiently between the processing of affective and non-affective information. Reports of asymmetrically increased switch costs when switching toward the more salient emotion task indicate specific demands in the flexible control of emotion. The neural mechanisms underlying affective task switching, however, are so far not fully understood. Using functional Magnetic Resonance Imaging (MRI) (N = 57), we observed that affective task switching was accompanied by increased activity in domain-general fronto-parietal control systems. Blood-oxygen-level-dependent (BOLD) activity in the posterior medial frontal and anterolateral prefrontal cortex was directly related to affective switch costs, indicating that these regions play a particular role in individual differences in (affective) task-switching ability. Asymmetric switch costs were associated with increased activity in the right inferior frontal and dorsal anterior medial prefrontal cortex, two brain regions critical for response inhibition. This suggests that asymmetric switch costs might—to a great extent—reflect higher demands on inhibitory control of the dominant emotion task. These results contribute to a refined understanding of brain systems for the flexible control of emotions and thereby identify valuable target systems for future clinical research.
A tarsometatarsus from the upper Eocene Na Duong Basin—the first Palaeogene fossil bird from Vietnam
2022-10-12

Knowledge of the Palaeogene avifauna of East Asia is scarce, and only a few fossils have been described thus far. A tarsometatarsus from the upper Eocene Na Duong Basin represents the first Palaeogene fossil bird from Vietnam. The fossiliferous sediments in the Na Duong Basin originated from an aquatic ecosystem but also yielded terrestrial animal and plant remains suggesting a dense forest habitat surrounding an ancient lake. In accordance, the Na Duong Basin tarsometatarsus is compared with extant aquatic, terrestrial and arboreal bird species, but because of diagenetic compression and fragmentary preservation, it is difficult to classify the bone. Nevertheless, the specimen exhibits a distinctive morphology and is potentially referable to an endemic neognath unknown from other Palaeogene localities outside of Vietnam.
Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity
2022-10-13

Incretin-based therapies with glucagon-like peptide-1 receptor agonists (GLP-1RA) are already established in the treatment of type 2 diabetes (T2D). The development of novel dual- or triple-receptor agonists that bind to the receptors not only for GLP-1 but also to the receptors for glucose-dependent insulinotropic polypeptide (GIP) and/or glucagon is intended to address different metabolic pathways for carbohydrate, lipid, and protein metabolism simultaneously. Dual- and triple-receptor agonists acting via different receptors and postreceptor pathways seem attractive in view of potentially additive or synergistic effects in the treatment of T2D and obesity. Recently, the first approval for a dual-receptor agonist marks an important step in this development. The GIP/GLP-1-receptor agonist tirzepatide was approved for the treatment of T2D by the Food and Drug Administration (FDA) in the USA for once-weekly subcutaneous injections in May 2022 and has just received a positive opinion from the European Medicines Agency (EMA). Tirzepatide dose-dependently leads to clinically significant reductions in glycemic parameters and body weight and has been shown to have stronger effects in reducing these parameters than standard antidiabetic therapy. This article summarizes the current clinical study program and the respective outcomes and highlights further potential indications for tirzepatide in the treatment of obesity and potentially other comorbidities of T2D.
Bounded rational decision-making models suggest capacity-limited concurrent motor planning in human posterior parietal and frontal cortex
2022-10-13

While traditional theories of sensorimotor processing have often assumed a serial decision-making pipeline, more recent approaches have suggested that multiple actions may be planned concurrently and vie for execution. Evidence for the latter almost exclusively stems from electrophysiological studies in posterior parietal and premotor cortex of monkeys. Here we study concurrent prospective motor planning in humans by recording functional magnetic resonance imaging (fMRI) during a delayed response task engaging movement sequences towards multiple potential targets. We find that also in human posterior parietal and premotor cortex delay activity modulates both with sequence complexity and the number of potential targets. We tested the hypothesis that this modulation is best explained by concurrent prospective planning as opposed to the mere maintenance of potential targets in memory. We devise a bounded rationality model with information constraints that optimally assigns information resources for planning and memory for this task and determine predicted information profiles according to the two hypotheses. When regressing delay activity on these model predictions, we find that the concurrent prospective planning strategy provides a significantly better explanation of the fMRI-signal modulations. Moreover, we find that concurrent prospective planning is more costly and thus limited for most subjects, as expressed by the best fitting information capacities. We conclude that bounded rational decision-making models allow relating both behavior and neural representations to utilitarian task descriptions based on bounded optimal information-processing assumptions.
Influence of Multimodal Treatment on Rest/Activity and Autonomic Regulation in Breast Cancer Patients with Cancer-Related Fatigue: Results of a Tri-Centre Trial with a Comprehensive Cohort Design
2022-10-13

Introduction: Breast cancer patients with cancer-related fatigue (BC-CRF) often have lower physical activity. To investigate how this could be improved, we evaluated a multimodal treatment (MT) and a combination of MT with aerobic training (CT) and compared these with aerobic training (AT) regarding rest/activity rhythm and state autonomic regulation (State aR). Methods: In this pragmatic comprehensive cohort design study, the explorative analysis focused on actigraphy and State aR including the rest/activity regulation subscale (State aR-R/A) which were assessed at baseline (T0), after 10 weeks of intervention (T1), and State aR additionally 6 months later (T2). Statistics: General linear modelling including propensity scores. Results: 65 BC-CRF were randomized, and 61 were allocated by preference to the treatment arms. 105 patients started the intervention. At T1, State aR-R/A improved the most in MT (+3.49, CI [2.42; 4.55]) compared to AT (+1.59, CI [0.13; 3.06]) and CT (+1.68, CI [0.83; 2.52]), showing superiority of MT to AT (p = 0.048). At T2 MT was sustainably superior to AT regarding State aR-R/A (+3.61, CI [2.38; 4.83] p &lt; 0.01) and State aR also showed superiority of MT to AT (p = 0.006). AT T1 24-h activity was higher in MT compared to AT (p = 0.029). Conclusions: MT was superior to AT regarding State aR total score after 6 months, State aR-R/A after 10 weeks, and after 6 months. Actigraphically measured total activity also improved after 10 weeks.
The Significance of Creativity for Teaching Philosophy
2022-10-13

Although creativity constitutes a central human ability that needs to be fostered in school, research in didactics of philosophy hasn’t so far developed accounts of how to train creativity systematically. In this paper I will provide the foundations for a didactics of creativity for philosophy and ethics education. The approach is based on the insight that creativity is an important competence to be promoted in philosophy and ethics classrooms. I will define the concept of creativity and review key empirical findings from the field of educational psychology and psychology of learning which will help me working out a framework for fostering creativity in the philosophy classroom. Central to this is the idea that creativity can only be taught if the use of creative task types is preceded by a phase of acquiring domain-specific philosophical and ethical competences and knowledge. I will then argue that this objective can be implemented particularly well through the design thinking method. In this context, task types that promote divergent thinking are particularly effective. I will use three classroom examples to illustrate how creativity could be fostered in philosophy and ethics classes.
AFDeter: A MATLAB-based tool for simple and rapid determination of the structural parameters and the airflow-related properties of fibrous materials
2022-10-13

AFDeter is an integrated software package, for research and study purposes, to simultaneously determine the structural parameters and airflow-related properties of fibrous materials based on their airflow penetration behavior. Some easily obtained data (i.e., airflow velocity and pressured drop) are used to obtain the parameters and properties by solving the inverse problem. AFDeter works with various fibrous materials, including conventional fibrous nonwoven fabrics and nanofibrous materials. Other functionalities are included, such as import data and bounds setting verifications. The operation of AFDeter is simple and convenient, and it can be run as a MATLAB-based app or standalone application.
A Survey of Wi-Fi 6: Technologies, Advances, and Challenges
2022-10-14

Wi-Fi is a popular wireless technology and is continuously extended to keep pace with requirements such as high throughput, real-time communication, dense networks, or resource and energy efficiency. The IEEE 802.11ax standard, also known as Wi-Fi 6, promises to provide data rates of up to almost 10 Gb/s, lower energy consumption, and higher reliability. Its capabilities go far beyond Wi-Fi 5 (802.11ac) and novel technical concepts have been introduced for this purpose. As such, the Wi-Fi 6 standard includes Multi-User Orthogonal Frequency Division Multiple Access (MU OFDMA), Multi-User Multiple-Input Multiple-Output (MU MIMO), new mechanisms for Spatial Reuse (SR), new mechanisms for power saving, higher-order modulation, and additional minor improvements. In this paper, we provide a survey of Wi-Fi 6. Initially, we provide a compact technological summary of Wi-Fi 5 and its predecessors. Then, we discuss the potential application domains of Wi-Fi 6, which are enabled through its novel features. Subsequently, we explain these features and review the related works in these areas. Finally, performance evaluation tools for Wi-Fi 6 and future roadmaps are discussed.
Complexity trade-offs and equi-complexity in natural languages: a meta-analysis
2022-10-14

Abstract In linguistics, there is little consensus on how to define, measure, and compare complexity across languages. We propose to take the diversity of viewpoints as a given, and to capture the complexity of a language by a vector of measurements, rather than a single value. We then assess the statistical support for two controversial hypotheses: the trade-off hypothesis and the equi-complexity hypothesis. We furnish meta-analyses of 28 complexity metrics applied to texts written in overall 80 typologically diverse languages. The trade-off hypothesis is partially supported, in the sense that around one third of the significant correlations between measures are negative. The equi-complexity hypothesis, on the other hand, is largely confirmed. While we find evidence for complexity differences in the domains of morphology and syntax, the overall complexity vectors of languages turn out virtually indistinguishable.
Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations
2022-10-14

For more than two years after the emergence of COVID-19 (Coronavirus Disease-2019), significant regional differences in morbidity persist. These differences clearly show lower incidence rates in several regions of the African and Asian continents. The work reported here aimed to test the hypothesis of a pre-pandemic natural immunity acquired by some human populations in central and western Africa, which would, therefore, pose the hypothesis of an original antigenic sin with a virus antigenically close to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). To identify such pre-existing immunity, sera samples collected before the emergence of COVID-19 were tested to detect the presence of IgG reacting antibodies against SARS-CoV-2 proteins of major significance. Sera samples from French blood donors collected before the pandemic served as a control. The results showed a statistically significant difference of antibodies prevalence between the collected samples in Africa and the control samples collected in France. Given the novelty of our results, our next step consists in highlighting neutralizing antibodies to evaluate their potential for pre-pandemic protective acquired immunity against SARS-CoV-2. In conclusion, our results suggest that, in the investigated African sub-regions, the tested populations could have been potentially and partially pre-exposed, before the COVID-19 pandemic, to the antigens of a yet non-identified Coronaviruses.
Recovery from chronic depression and structural change: 5‐year outcomes after psychoanalytic and cognitive‐behavioural long‐term treatments (LAC depression study)
2022-10-14

Abstract Objective Psychotherapy of chronic depression has remained a challenge due to limited prognosis and high rates of recurrence. We present 5‐year outcome data from a multicentre trial comparing psychoanalytic (PAT) and cognitive‐behavioural (CBT) long‐term treatments with randomized and preferred allocations analysing symptom ( N = 227) and structural change ( N = 134) trajectories. Method Self‐ and blinded expert ratings of depression symptoms were performed at yearly intervals using the Beck Depression Inventory‐II (BDI‐II) and Quick Inventory of Depressive Symptoms (QIDS‐C). Blinded expert ratings of Operationalized Psychodynamic Diagnosis (OPD) and the Heidelberg Restructuring Scale (HRS) at baseline, 1, 3, and 5 years assessed structural change in a subsample. Results Lasting and comparable symptom changes were achieved by PAT and CBT. However, compared to CBT, PAT was more successful in restructuring, a major goal of long‐term psychodynamic treatments with high frequency and duration. Limitations Due to practical reasons, the time criterion for chronic depression of an acute phase had to be defined for over 1 year in the present study, which does not correspond to the DSM‐5 criterion of 2 years. Therapy duration and session frequency were not incorporated into the statistical models. Conclusion Long‐term psychotherapy helps patients with a yearlong history of depression and often multiple unsuccessful treatment attempts to achieve lasting symptom changes. Future follow‐up will clarify whether restructuring promotes further sustainable improvements.
Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia
2022-10-14

Background Cleidocranial dysplasia (CCD) is a rare skeletal dysplasia with significant clinical variability. Patients with CCD typically present with delayed closure of fontanels and cranial sutures, dental anomalies, clavicular hypoplasia or aplasia and short stature. Runt-related transcription factor 2 ( RUNX2) is currently the only known disease-causing gene for CCD, but several studies have suggested locus heterogeneity. Methods The cohort consists of eight subjects from five unrelated families partially identified through GeneMatcher. Exome or genome sequencing was applied and in two subjects the effect of the variant was investigated at RNA level. Results In each subject a heterozygous pathogenic variant in CBFB was detected, whereas no genomic alteration involving RUNX2 was found. Three CBFB variants (one splice site alteration, one nonsense variant, one 2 bp duplication) were shown to result in a premature stop codon. A large intragenic deletion was found to delete exon 4, without affecting CBFB expression. The effect of a second splice site variant could not be determined but most likely results in a shortened or absent protein. Affected individuals showed similarities with RUNX2 -related CCD, including dental and clavicular abnormalities. Normal stature and neurocognitive problems were however distinguishing features. CBFB encodes the core-binding factor β subunit, which can interact with all RUNX proteins (RUNX1, RUNX2, RUNX3) to form heterodimeric transcription factors. This may explain the phenotypic differences between CBFB -related and RUNX2 -related CCD. Conclusion We confirm the previously suggested locus heterogeneity for CCD by identifying five pathogenic variants in CBFB in a cohort of eight individuals with clinical and radiographic features reminiscent of CCD.
Residual neural networks for the prediction of planetary collision outcomes
2022-10-14

ABSTRACT Fast and accurate treatment of collisions in the context of modern N-body planet formation simulations remains a challenging task due to inherently complex collision processes. We aim to tackle this problem with machine learning (ML), in particular via residual neural networks. Our model is motivated by the underlying physical processes of the data-generating process and allows for flexible prediction of post-collision states. We demonstrate that our model outperforms commonly used collision handling methods such as perfect inelastic merging and feed-forward neural networks in both prediction accuracy and out-of-distribution generalization. Our model outperforms the current state of the art in 20/24 experiments. We provide a data set that consists of 10164 Smooth Particle Hydrodynamics (SPH) simulations of pairwise planetary collisions. The data set is specifically suited for ML research to improve computational aspects for collision treatment and for studying planetary collisions in general. We formulate the ML task as a multi-task regression problem, allowing simple, yet efficient training of ML models for collision treatment in an end-to-end manner. Our models can be easily integrated into existing N-body frameworks and can be used within our chosen parameter space of initial conditions, i.e. where similar-sized collisions during late-stage terrestrial planet formation typically occur.
Mean opacities of a strongly magnetized high-temperature plasma
2022-10-14

ABSTRACT Geometry and dynamical structure of emission regions in accreting pulsars are shaped by the interplay between gravity, radiation, and strong magnetic field, which significantly affects the opacities of a plasma and radiative pressure under such extreme conditions. Quantitative consideration of magnetic plasma opacities is therefore an essential ingredient of any self-consistent modelling of emission region structure of X-ray pulsars (XRPs). We present results of computations of the Rosseland and Planck mean opacities of a strongly magnetized plasma with a simple chemical composition, namely the solar hydrogen/helium mix. We consider all relevant specific opacities of the magnetized plasma including vacuum polarization effect and contribution of electron–positron pairs where the pair number density is computed in the thermodynamic equilibrium approximation. The magnetic Planck mean opacity determines the radiative cooling of an optically thin strongly magnetized plasma. It is by factor of three smaller than non-magnetic Planck opacity at and increases by a factor of 102–104 at due to cyclotron thermal processes. We propose a simple approximate expression which has sufficient accuracy for the magnetic Planck opacity description. We provide the Rosseland opacity in a tabular form computed in the temperature range 1–300 keV, magnetic field range 3 × 1010–1015 G, and a broad range of plasma densities. We demonstrate that the scattering on the electron–positron pairs increases the Rosseland opacity drastically at temperatures &amp;gt; 50 keV in the case of mass densities typical for accretion channel in XRPs.