julilili42/papers huggingface dataset:
ELF Communication: From Pedagogical Catalyst to ELT Game Changer
2022-12-30

Raising speaker-learners’ and their teachers’ awareness of the possibilities and challenges of authentic ELF communication is a powerful catalyst in the process of understanding what it means to be out in the wild. But where do they turn for orientation when it comes to their own spoken and written productions? From a social constructivist perspective, I argue that ELT’s standard native speaker orientation is not the problem. Rather, what counts is what speaker-learners are allowed and encouraged to do with it. Against this backdrop, I propose a pedagogical lingua franca approach that moves ELF communication from a position outside ELT to a game changer position inside ELT and helps learners develop their own voice as emancipated non-native speakers of English.
Symmetry and symmetry breaking in science and arts
2022-12-30

In this review article, symmetry and symmetry breaking are considered as complementary principles in science and arts. It starts with symmetry and symmetry breaking in early world views of nature and art. Then, symmetries are definied as fundamental structures of mathematics. Mathematical models of symmetry and symmetry breaking are used to explain the emergence of space-time and matter in modern physics. Even molecular structures in chemistry are distinguished by mathematical symmetries. Their elegance and beauty seem to realize aesthetical categories in nature. In biological evolution, the question arises how symmetry breaking (e.g. molcular chirality) can be explained. In modern arts, symmetry and symmetry breaking are "hidden" structures which can be found in music, painting, and architecture. In a philosophical outlook, symmetry and symmetry breaking are highlighted as regulative guiding ideas of research. _______________________________________________________________________________________________________________________________________________________ This article is an extended version and English translation of my article "Symmetrie und Symmetriebrechung. Von der Urmaterie zu Kunst und Leben,“ in: Schriftenreihe der Heisenberg-Gesellschaft: Quanten 2 (ed. Konrad Kleinknecht), S. Hirzel Verlag, 9-59. An abridged version was presented in the EASA Colloquium Science meets Art (https://www.youtube.com/watch?v=nIUVNEQ7AR8 )
Of Cows and Gods: Secret Names in the Rigveda
2022-12-30

In the poems of the Rigveda (Ṛgveda) not only are the gods of the Vedic pantheon praised and in return asked for the fulfillment of various wishes, there are also numerous statements about the poetry by means of which these requests are brought forward. In many Rigvedic hymns reference is made to poetic language and its special character and already at this early stage a terminology is developed with which this language is analyzed. One of the key terms is nā́man, usually translated as the cognate “name”, but with a much larger scope of meaning, comprising “essence” as well as “form of appearance”. Furthermore, its use is not restricted to concrete beings, as it has also been applied to e. g. denote state of affairs. These features have already been extensively treated in the literature yet it might be worthwhile to take a closer look at a seemingly paradoxical circumstance: On the one hand, some of these names are said to be secret, and they are mentioned, but never quoted. On the other hand, Rigvedic poetry accompanies ongoing ritual activities and is recited in public. After a survey of the most important features of names it will be argued that these names are simultaneously secret and recited in public, and that the Rigvedic poets used the full range of poetic devices to achieve this.
Symmetry and Symmetry Breaking in Science and Arts
2022-12-30

In this review article, symmetry and symmetry breaking are considered as complementary principles in science and arts. It starts with symmetry and symmetry breaking in early world views of nature and art. Then, symmetries are definied as fundamental structures of mathematics. Mathematical models of symmetry and symmetry breaking are used to explain the emergence of space-time and matter in modern physics. Even molecular structures in chemistry are distinguished by mathematical symmetries. Their elegance and beauty seem to realize aesthetical categories in nature. In biological evolution, the question arises how symmetry breaking (e.g. molcular chirality) can be explained. In modern arts, symmetry and symmetry breaking are „hidden“ structures which can be found in music, painting, and architecture. In a philosophical outlook, symmetry and symmetry breaking are highlighted as regulative guiding ideas of research.
Accelerated and quantitative three‐dimensional molecular MRI using a generative adversarial network
2022-12-31

Purpose To substantially shorten the acquisition time required for quantitative three‐dimensional (3D) chemical exchange saturation transfer (CEST) and semisolid magnetization transfer (MT) imaging and allow for rapid chemical exchange parameter map reconstruction. Methods Three‐dimensional CEST and MT magnetic resonance fingerprinting (MRF) datasets of L‐arginine phantoms, whole‐brains, and calf muscles from healthy volunteers, cancer patients, and cardiac patients were acquired using 3T clinical scanners at three different sites, using three different scanner models and coils. A saturation transfer‐oriented generative adversarial network (GAN‐ST) supervised framework was then designed and trained to learn the mapping from a reduced input data space to the quantitative exchange parameter space, while preserving perceptual and quantitative content. Results The GAN‐ST 3D acquisition time was 42–52 s, 70% shorter than CEST‐MRF. The quantitative reconstruction of the entire brain took 0.8 s. An excellent agreement was observed between the ground truth and GAN‐based L‐arginine concentration and pH values (Pearson's r &gt; 0.95, ICC &gt; 0.88, NRMSE &lt; 3%). GAN‐ST images from a brain‐tumor subject yielded a semi‐solid volume fraction and exchange rate NRMSE of and , respectively, and SSIM of and , respectively. The mapping of the calf‐muscle exchange parameters in a cardiac patient, yielded NRMSE &lt; 7% and SSIM &gt; 94% for the semi‐solid exchange parameters. In regions with large susceptibility artifacts, GAN‐ST has demonstrated improved performance and reduced noise compared to MRF. Conclusion GAN‐ST can substantially reduce the acquisition time for quantitative semi‐solid MT/CEST mapping, while retaining performance even when facing pathologies and scanner models that were not available during training.
Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4‐Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family
2022-12-31

Abstract Lysine acetylation is a charge‐neutralizing post‐translational modification of proteins bound by bromodomains (Brds). A 1,2,4‐triazole amino acid (ApmTri) was established as acetyllysine (Kac) mimic recruiting Brds of the BET family in contrast to glutamine commonly used for simulating this modification. Optimization of triazole substituents and side chain spacing allowed BET Brd recruitment to ApmTri‐containing peptides with affinities similar to native substrates. Crystal structures of ApmTri‐containing peptides in complex with two BET Brds revealed the binding mode which mirrored that of Kac ligands. ApmTri was genetically encoded and recombinant ApmTri‐containing proteins co‐enriched BRD3(2) from cellular lysates. This interaction was blocked by BET inhibitor JQ1. With genetically encoded ApmTri, biochemistry is now provided with a stable Kac mimic reflecting charge neutralization and Brd recruitment, allowing new investigations into BET proteins in vitro and in vivo.
A generating model for Finnish nominal inflection using distributional semantics
2022-12-31

Abstract Finnish nouns are characterized by rich inflectional variation, with obligatory marking of case and number, with optional possessive suffixes and with the possibility of further cliticization. We present a model for the conceptualization of Finnish inflected nouns, using pre-compiled fasttext embeddings (300-dimensional semantic vectors that approximate words’ meanings). Instead of deriving the semantic vector of an inflected word from another word in its paradigm, we propose that an inflected word is conceptualized by means of summation of latent vectors representing the meanings of its lexeme and its inflectional features. We tested this model on the 2,000 most frequent Finnish nouns and their inflected word forms from a corpus of Finnish (84 million tokens). Visualization of the semantic space of Finnish using t-SNE clarified that a ‘main effects’ additive model does not do justice to the semantics of inflection. In Finnish, how number is realized turns out to vary substantially with case. Further interactions emerged with the possessive suffixes and the clitics. By taking these interactions into account, the accuracy of our model, evaluated with the fasttext embeddings as gold standard, improved from 76% to 89%. Analyses of the errors made by the model clarified that 7.5% of errors are due to overabundance (and hence not true errors), and that 16.5% of the errors involved exchanges of semantically highly similar stems (lexemes). Our results indicate, first, that the semantics of Finnish noun inflection are more intricate than assumed thus far, and second, that these intricacies can be captured with surprisingly high accuracy by a simple generating model based on imputed semantic vectors for lexemes, inflectional features, and interactions of inflectional features.
Decorin improves human pancreatic β-cell function and regulates ECM expression in vitro
2022-12-31

Transplantation of islets of Langerhans is a promising alternative treatment strategy in severe cases of type 1 diabetes mellitus; however, the success rate is limited by the survival rate of the cells post-transplantation. Restoration of the native pancreatic niche during transplantation potentially can help to improve cell viability and function. Here, we assessed for the first time the regulatory role of the small leucine-rich proteoglycan decorin (DCN) in insulin secretion in human β-cells, and its impact on pancreatic extracellular matrix (ECM) protein expression in vitro. In depth analyses utilizing next-generation sequencing as well as Raman microspectroscopy and Raman imaging identified pathways related to glucose metabolism to be upregulated in DCN-treated cells, including oxidative phosphorylation within the mitochondria as well as proteins and lipids of the endoplasmic reticulum. We further showed the effectiveness of DCN in a transplantation setting by treating collagen type 1-encapsulated β-cell-containing pseudo-islets with DCN. Taken together, in this study, we demonstrate the potential of DCN to improve the function of insulin-secreting β-cells while reducing the expression of ECM proteins affiliated with fibrotic capsule formation, making DCN a highly promising therapeutic agent for islet transplantation.
Paradigm gaps are associated with weird “distributional semantics” properties
2022-12-31

Abstract This study investigates the phenomenon of defectiveness in Russian case and number noun paradigms from the perspective of distributional semantics. We made use of word embeddings, high-dimensional vectors trained from large text corpora, and compared the observed paradigms of nouns that are defective in the genitive plural, as suggested by Zaliznjak (1977) , with the observed paradigms for non-defective nouns. When the embeddings of about 20,000 inflected forms were projected onto a two-dimensional space, clusters of case and number within case were found, suggesting global semantic similarity for words with the same inflectional features. Moreover, defective lexemes were characterized by lower semantic transparency, in that inflected forms of the same lexeme are semantically less similar to each other, and their meanings are also more idiosyncratic. Furthermore, compared to non-defective lexemes, inflected forms from defective lexemes are further away from the idealized average case-number meanings, obtained by averaging over the vectors of all inflected forms of the same case-number combination. As a consequence, the semantics of defective forms are predicted less precisely by a simple model of conceptualization that assumes that the meaning of a given Russian inflected form is approximated well by the sum of pertinent embeddings of the lexeme, case, and number within case. We conclude that the relationship between defectiveness and semantics, at least the kind captured by word embeddings, is stronger than has been anticipated previously.
Early Ultrastructural Changes in Biopsies From Patients With Symptomatic CKD of Uncertain Etiology
2022-12-31

In conclusion, our findings confirm the predominant and early alterations of tubular structure in CKDu that can occur without significant glomerular changes. The ultrastructural changes do not provide concrete evidence of the cause of CKDu but were significantly more frequent in Sym-CKDu than in the controls.
An inquiry into the semantic transparency and productivity of German particle verbs and derivational affixation
2022-12-31

Abstract This study addresses the relation between morphological productivity and semantic transparency. Using distributional semantics, we compare German word formation using particles with derivational word formation. We observed that derivational suffixes, but not particles, tend to make strong independent semantic contributions to their carrier words. In two-dimensional t-SNE maps, complex words show clustering by affix, but not by particle. Furthermore, the semantic vectors of suffixed words are predictable from their base words with higher accuracy than is possible for particle verbs. For particle verbs, but not affixed verbs, semantic similarity within the set of complex words correlated negatively with the number of types. Furthermore, only for particle verbs, a greater number of observed types predicted a reduced probability of observing unseen types. We propose that particle verbs primarily serve the onomasiological function of labeling, resulting in relatively idiosyncratic semantic vectors. By contrast, words sharing derivational affixes form distinct clusters in semantic space while maintaining strong and consistent semantic relations with their base words. This enables these words to serve not only as labels, but also allows them to be used with an anaphoric function in discourse.
Making sense of spoken plurals
2022-12-31

Abstract Distributional semantics offers new ways to study the semantics of morphology. This study focuses on the semantics of noun singulars and their plural inflectional variants in English. Our goal is to compare two models for the conceptualization of plurality. One model (FRACSS) proposes that all singular-plural pairs should be taken into account when predicting plural semantics from singular semantics. The other model (CCA) argues that conceptualization for plurality depends primarily on the semantic class of the base word. We compare the two models on the basis of how well the speech signal of plural tokens in a large corpus of spoken American English aligns with the semantic vectors predicted by the two models. Two measures are employed: the performance of a form-to-meaning mapping and the correlations between form distances and meaning distances. Results converge on a superior alignment for CCA. Our results suggest that usage-based approaches to pluralization in which a given word’s own semantic neighborhood is given priority outperform theories according to which pluralization is conceptualized as a process building on high-level abstraction. We see that what has often been conceived of as a highly abstract concept, [+ plural ], is better captured via a family of mid-level partial generalizations.
Between placeholder and filler
2022-12-31

Abstract French truc and machin (‘thing’) can function as placeholders, fillers or in general extender constructions. The aim of our paper is to investigate whether the prosodic characteristics of these three different uses may give a clue as to their respective status. For our analysis, we extracted 112 occurrences of truc and 57 occurrences of machin from the audio data of the PFC Corpus, which were analysed using Praat, focusing on the acoustic duration, the individual pitch contour and the integration of machin and truc into the intonation contour of the utterance. As in previous studies, our results show that the prosodic patterns vary remarkably and show a highly heterogeneous picture so that the use of prosodic properties as cues for disambiguation is problematic. However, we are able to show some weak tendencies which point to a close functional link between placeholders and fillers reflecting their pragmatic functions. There is no evidence for prosodic weakening or even phonetic reduction in placeholders. Furthermore, we detect some evidence for the detachment typical of pragmatic markers in the case of fillers. The prosodic characteristics of truc and machin in general extender constructions diverge from both the placeholder and the filler functions. Their prosody seems to be largely determined by the particular respective construction into which both forms are strongly integrated.
Social appropriateness in HMI
2022-12-31

Abstract Social appropriateness is an important topic – both in the human-human interaction (HHI), and in the human-machine interaction (HMI) context. As sociosensitive and socioactive assistance systems advance, the question arises whether a machine’s behavior should include considerations regarding social appropriateness. However, the concept of social appropriateness is difficult to define, as it is determined by multiple aspects. Thus, to date, a unified perspective, encompassing and combining multidisciplinary findings, is missing. When translating results from HHI to HMI, it remains unclear whether such insights into the dynamics of social appropriateness between humans may in fact apply to sociosensitive and socioactive assistance systems. To shed light on this matter, we propose the Five Factor Model of Social Appropriateness (FASA) which provides a multidisciplinary perspective on the notion of social appropriateness and its implementation into technical systems. Finally, we offer reflections on the applicability and ethics of the FASA Model, highlighting both strengths and limitations of the framework.
Tropical ψ classes
2022-12-31

We introduce a tropical geometric framework that allows us to define ψ classes for moduli spaces of tropical curves of arbitrary genus.We prove correspondence theorems between algebraic and tropical ψ classes for some one-dimensional families of genus-one tropical curves.
Productivity and semantic transparency
2022-12-31

Abstract We used word embeddings to study the relation between productivity and semantic transparency. We compiled a dataset with around 2700 two-syllable compounds that shared position-specific constituents (henceforth pivots) and some 1100 suffixed words. For each pivot and suffix, we calculated measures of productivity as well as measures of semantic transparency. For compounds, productivity ( P ) was negatively correlated with the number of types ( V ) and with the semantic similarity between non-pivot constituents and their compounds. Conversely, the greater semantic similarity of the pivot with either the compound or the non-pivot constituent predicted higher degrees of productivity. Visualization with t-SNE revealed clustering of suffixed words’ embeddings, but no by-pivot clustering for compounds, except for a minority of pivots whose regions in semantic space did not contain intruding unrelated compounds. A subset of these pivots was found to realize a fixed shift in semantic space from the base word to the corresponding compound, a property that also emerged for several suffixes. For these pivots, no correlation between P and V was present. Thus, Mandarin compounds appear to realize, at one extreme, motivated but unsystematic concept formation (where other pivots could just as well have been used), and at the other extreme, systematic suffix-like semantics.
Does students' awareness of school track-related-stereotypes exacerbate inequalities in education?
2022-12-31

Early ability tracking increases inequalities in education. It has been proposed that the awareness of negative school-track-related stereotypes contributes to educational inequalities as they particularly hinder the thriving of students in lower, stigmatized tracks. The present study tested this assumption in a sample of 3,880 German secondary school students from three tracks, who were assessed four times on stereotype awareness regarding their own school track and academic outcomes (achievement, engagement, self-concept) between Grades 5 and 8. Students in the lowest track reported higher levels of stereotype awareness than higher track students or students attending a combined track. Stereotype awareness increased across time in all tracks. Contrary to our preregistered hypotheses, however, (changes in) stereotype awareness were not more strongly related to (changes in) most outcomes in the lowest track in comparison with the other two tracks.
We don’t know what you did last summer. On the importance of transparent reporting of reaction time data pre-processing
2022-12-31

In behavioral, cognitive, and social sciences, reaction time measures are an important source of information. However, analyses on reaction time data are affected by researchers’ analytical choices and the order in which these choices are applied. The results of a systematic literature review, presented in this paper, revealed that the justification for and order in which analytical choices are conducted are rarely reported, leading to difficulty in reproducing results and interpreting mixed findings. To address this methodological shortcoming, we created a checklist on reporting reaction time pre-processing to make these decisions more explicit, improve transparency, and thus, promote best practices within the field. The importance of the pre-processing checklist was additionally supported by an expert consensus survey and a multiverse analysis. Consequently, we appeal for maximal transparency on all methods applied and offer a checklist to improve replicability and reproducibility of studies that use reaction time measures.
Astrophysics with the Laser Interferometer Space Antenna
2023-01-01

The Laser Interferometer Space Antenna (LISA) will be a transformative experiment for gravitational wave astronomy, and, as such, it will offer unique opportunities to address many key astrophysical questions in a completely novel way. The synergy with ground-based and space-born instruments in the electromagnetic domain, by enabling multi-messenger observations, will add further to the discovery potential of LISA. The next decade is crucial to prepare the astrophysical community for LISA’s first observations. This review outlines the extensive landscape of astrophysical theory, numerical simulations, and astronomical observations that are instrumental for modeling and interpreting the upcoming LISA datastream. To this aim, the current knowledge in three main source classes for LISA is reviewed; ultra-compact stellar-mass binaries, massive black hole binaries, and extreme or interme-diate mass ratio inspirals. The relevant astrophysical processes and the established modeling techniques are summarized. Likewise, open issues and gaps in our understanding of these sources are highlighted, along with an indication of how LISA could help making progress in the different areas. New research avenues that LISA itself, or its joint exploitation with upcoming studies in the electromagnetic domain, will enable, are also illustrated. Improvements in modeling and analysis approaches, such as the combination of numerical simulations and modern data science techniques, are discussed. This review is intended to be a starting point for using LISA as a new discovery tool for understanding our Universe.