julilili42/papers huggingface dataset:
Phase diagrams for sticky rods in bulk and in a monolayer from a lattice free-energy functional for anisotropic particles with depletion attractions
2017-09-20

A density functional of fundamental measure type for a lattice model of anisotropic particles with hard-core repulsions and effective attractions is derived in the spirit of the Asakura-Oosawa model. Through polymeric lattice particles of various size and shape, effective attractions of different strength and range between the colloids can be generated. The functional is applied to the determination of phase diagrams for sticky rods of length L in two dimensions, in three dimensions, and in a monolayer system on a neutral substrate. In all cases, there is a competition between ordering and gas-liquid transitions. In two dimensions, this gives rise to a tricritical point, whereas in three dimensions, the isotropic-nematic transition crosses over smoothly to a gas-nematic liquid transition. The richest phase behavior is found for the monolayer system. For L=2, two stable critical points are found corresponding to a standard gas-liquid transition and a nematic liquid-liquid transition. For L=3, the gas-liquid transition becomes metastable.
Dephosphorylation is the Mechanism of Fibroblast Growth Factor Inhibition of Guanylyl Cyclase-B
2017-09-20

Abstract Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations of guanylyl cyclase-B (GC-B, also called NPRB or NPR2) cause dwarfism. FGF exposure inhibits GC-B activity in a chondrocyte cell line, but the mechanism of the inactivation is not known. Here, we report that FGF exposure causes dephosphorylation of GC-B in rat chondrosarcoma cells, which correlates with a rapid, potent and reversible inhibition of C-type natriuretic peptide-dependent activation of GC-B. Cells expressing a phosphomimetic mutant of GC-B that cannot be inactivated by dephosphorylation because it contains glutamate substitutions for all known phosphorylation sites showed no decrease in GC-B activity in response to FGF. We conclude that FGF rapidly inactivates GC-B by a reversible dephosphorylation mechanism, which may contribute to the signaling network by which activated FGFR3 causes dwarfism. Highlights Guanylyl Cyclase-B is expressed in rat chondrosarcoma cells FGF2 induces a rapid, potent, and reversible inhibition of GC-B FGF2 treatment causes GC-B dephosphorylation FGF2 does not inhibit a dephosphorylation-resistant form of GC-B Dephosphorylation is the mechanism of FGF2-dependent inhibition of GC-B Abbreviations cGMP cyclic guanosine monophosphate GC guanylyl cyclase NP natriuretic peptide PBS phosphate buffered saline WT wild type
„Der Blick des Anderen“ – Machtkonstellationen aus existenzphilosophischer Perspektive: Sartres Weg vom Individuum zur Gruppe
2017-09-20

Summary “The Look of the Other” – Constellations of Power: Existential-philosophical Reflections: Sartre’s Road from the Individual to the Group The fundamental structure of a (therapeutic) group is not solely constituted by way of questioning the phenomena of power and powerlessness. The way in which this question is framed is itself representative of given constellations of power and the affective dispositions as these prevail in society as a whole. J.-P. Sartre undertook a detailed study of such phenomena along with an analysis of their subsequent Marxist revision in the concluding sections of his work on existential philosophy – an endeavour which warrants further philosophical and group-analytical review. Indeed, somewhat surprisingly, it was by way of Foulkes approach to group analysis that Sartre‘s analysis achieved compatible and affine results.
Validation of the MESSi among adult workers and young students: General health and personality correlates
2017-09-21

The aim of this study was to provide validity for the Spanish version of the Morningness-Eveningness-Stability Scale - improved (MESSi), a novel evolved assessment of circadian typology which considers the subjective phase and amplitude by morning affect (MA), eveningness (EV) and distinctness (DI; subjective amplitude) sub-scales. Convergence validity of the MESSi with the reduced Morningness-Eveningness Questionnaire (rMEQ) and relationships with the General Health Questionnaire (GHQ-12) and sensitivity to reward and punishment (SR and SP) were analyzed. Two different Spanish samples, young undergraduate students (n = 891, 18-30 years) and adult workers (n = 577, 31-65 years) participated in this study. Exploratory structural equation modeling (ESEM) of MESSi displayed acceptable fit of a three-factors measurement model. Percentiles of the MA, EV and DI sub-scales were obtained for students and adults. The MESSi showed good convergence validity with the rMEQ scores, with a higher correlation coefficient between MA, EV and lower with DI sub-scales. In both, young students and adult workers, MA was negatively related with the GHQ-12 and SP, but the percentage of explained variance (6% and 3%) was lower than the positive correlations between DI, the GHQ-12 and SP (20% and 13%). Morning types presented higher MA and lower EV scores than the other two typologies in both students and adult workers, whereas only differences in DI were found among students (lowest in evening type). Candidates to psychological symptoms and mental disorders ("true cases"), with the clinical cut-off criteria of the GHQ-12, showed lower MA and higher DI in students, whereas only DI was higher for "true cases" among adults. These results supported that subjective amplitude is a factor related to, but also differentiated of, morningness-eveningness (preferred time for a certain activity). The measure of amplitude might be more important than circadian phase in health consequences.
Molecular Mechanisms of Glioma Cell Motility
2017-09-21

Gliomas are the most common intracranial tumors in humans. The most malignant among these tumors is glioblastoma (GBM), with an incidence of 3–5 out of 100,000 persons in Western countries. GBM arises either de novo (primary GBM) or develops from a lower grade glioma (secondary GBM). The prognosis is poor. GBMs are lethal tumors and even optimal surgical resection, followed by chemotherapy and irradiation, results in a median survival of about 12–15 months. One characteristic that is responsible for GBM malignancy, and its worse prognosis, is the highly infiltrative growth of GBM cells into the healthy brain. GBM cell migration and invasion is a very complex process that is regulated by several factors, which include changes in the migrating cell itself as well as the tumor microenvironment. This chapter provides an overview of routes of invasion of glioma cells, the signaling pathways that drive glioma cell motility, and the processes through which glioma cells modulate their surrounding environment.
Pre-service teachers’ perceived value of general pedagogical knowledge for practice: Relations with epistemic beliefs and source beliefs
2017-09-21

Pre-service teachers tend to devalue general pedagogical knowledge (GPK) as a valid source for deriving successful teaching practices. The present study investigated beliefs about knowledge sources and epistemic beliefs as predictors for students' perceived value of GPK. Three pre-registered hypotheses were tested. We expected beliefs that GPK originates from scientific sources to entail a devaluation of GPK (Hypothesis 1). Concerning epistemic beliefs, we expected absolute beliefs to positively, and multiplistic beliefs to negatively predict pre-service teachers' perceived practical value of GPK (Hypothesis 2). Finally, we expected relationships between epistemic beliefs and pre-service teachers' perceived practical value of GPK to be confounded by epistemic trustworthiness, perceived topic-specific consistency and topic-specific familiarity (Hypothesis 3). In a study using a split plot design, 365 pre-service teachers were presented with four texts on different educational research topics. For each topic, three text versions were constructed. Even though they were invariant in content, these versions varied in a way that the results were allegedly generated by a practitioner, an expert or by means of a scientific study. Unexpectedly, results showed that research findings allegedly generated by means of a scientific study were associated with a higher perceived value of (topic-specific) GPK for practice (Hypothesis 1). As expected, the perceived value of GPK for practice was predicted by topic-specific multiplism and domain-specific absolutism (Hypothesis 2). These predictive effects were confounded by expertise evaluations of the source and the consistency of prior beliefs with the presented research results (Hypothesis 3). In summary, our results suggest that source beliefs might not be responsible for the devaluation of GPK, but that beliefs on the nature and structure of GPK (i.e., epistemic beliefs) might play an even more important role in this respect. Implications for research and practice are discussed.
End-member modelling as a tool for climate reconstruction—An Eastern Mediterranean case study
2017-09-21

The Eastern Mediterranean Sea is a sink for terrigenous sediments from North Africa, Europe and Asia Minor. Its sediments therefore provide valuable information on the climate dynamics in the source areas and the associated transport processes. We present a high-resolution dataset of sediment core M40/4_SL71, which was collected SW of Crete and spans the last ca. 180 kyr. We analysed the clay mineral composition, the grain size distribution within the silt fraction, and the abundance of major and trace elements. We tested the potential of end-member modelling on these sedimentological datasets as a tool for reconstructing the climate variability in the source regions and the associated detrital input. For each dataset, we modelled three end members. All end members were assigned to a specific provenance and sedimentary process. In total, three end members were related to the Saharan dust input, and five were related to the fluvial sediment input. One end member was strongly associated with the sapropel layers. The Saharan dust end members of the grain size and clay mineral datasets generally suggest enhanced dust export into the Eastern Mediterranean Sea during the dry phases with short-term increases during Heinrich events. During the African Humid Periods, dust export was reduced but may not have completely ceased. The loading patterns of two fluvial end members show a strong relationship with the Northern Hemisphere insolation, and all fluvial end members document enhanced input during the African Humid Periods. The sapropel end member most likely reflects the fixation of redox-sensitive elements within the anoxic sapropel layers. Our results exemplify that end-member modelling is a valuable tool for interpreting extensive and multidisciplinary datasets.
Embodied cognition: Is activation of the motor cortex essential for understanding action verbs?
2017-09-21

In 8 experiments using language processing tasks ranging from lexical decision to sensibility judgment, participants made hand or foot responses after reading hand- or foot-associated words such as action verbs. In general, response time (RT) tended to be faster when the hand- versus foot-associated word was compatible with the limb that was required to respond (e.g., hand response to a hand-associated word) than when it was incompatible (e.g., foot response to a hand-associated word). To see whether this compatibility effect reflects differential hand- versus foot-specific motor activation produced by the words, as suggested by some embodied theories of language understanding, we monitored 2 event-related potential (ERP) measures previously found to be sensitive to the activation of these limbs. As expected, the ERP results replicated previous findings that the monitored ERPs differ for hand versus foot movements. More importantly, the ERPs provided no evidence of any difference for hand- versus foot-associated words. Thus, the results weaken previous claims that the understanding of action verbs requires activation of the motor areas used to carry out the named action. Instead, they support claims that language-related compatibility effects on RT may arise prior to motor processes, which implies that such effects are not decisive evidence for embodied language understanding. (PsycINFO Database Record
Construction and updating of event models in auditory event processing.
2017-09-21

Humans segment the continuous stream of sensory information into distinct events at points of change. Between 2 events, humans perceive an event boundary. Present theories propose changes in the sensory information to trigger updating processes of the present event model. Increased encoding effort finally leads to a memory benefit at event boundaries. Evidence from reading time studies (increased reading times with increasing amount of change) suggest that updating of event models is incremental. We present results from 5 experiments that studied event processing (including memory formation processes and reading times) using an audio drama as well as a transcript thereof as stimulus material. Experiments 1a and 1b replicated the event boundary advantage effect for memory. In contrast to recent evidence from studies using visual stimulus material, Experiments 2a and 2b found no support for incremental updating with normally sighted and blind participants for recognition memory. In Experiment 3, we replicated Experiment 2a using a written transcript of the audio drama as stimulus material, allowing us to disentangle encoding and retrieval processes. Our results indicate incremental updating processes at encoding (as measured with reading times). At the same time, we again found recognition performance to be unaffected by the amount of change. We discuss these findings in light of current event cognition theories. (PsycINFO Database Record
Expanding the phenotype of DNAJC3 mutations: A case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration
2017-09-21

Identification of this additional patient from a distant part of the originally described pedigree (Synofzik et al. 2014) confirms pathogenicity of DNAJC3 mutations. Hypothyroidism is a newly identified feature in addition to the known phenotype (diabetes with multisystemic neurodegeneration).
A safety evaluation of empagliflozin plus linagliptin for treating type 2 diabetes
2017-09-21

Dipeptidyl-peptidase-IV inhibitors (DPP-4i) and sodium-glucose-transporter-2 inhibitors (SGLT-2i) are oral antidiabetic drugs that improve glycemic parameters and possess a very low intrinsic hypoglycemia risk and favorable cardiovascular data. Areas covered: An overview on the clinical studies investigating the combination therapy with the DPP-4i linagliptin and the SGLT-2i empagliflozin is given. The clinical evidence for the efficacy and safety of free combinations as well as for their fixed dose combinations is presented. Empagliflozin has recently proved to reduce cardiovascular risk in type 2 diabetes and cardiovascular high risk situations. A fixed dose combination (FDC) of empagliflozin and linagliptin as add on therapy to metformin or as initial treatment lowered the HbA1c by approximately 1.1% and reduced the body weight by 2.0-3.0 kg. The hypoglycemia risk was not significantly increased. The relevant studies were identified by a search in Medline and in clinicaltrials.gov. Expert opinion/commentary: A DPP-4i/SGLT-2i FDC may be especially useful to simplify treatment, to reduce the tablet burden and to increase medication adherence. This FDC may be particularly beneficial for patients where the reduction of body weight, blood pressure and cardiovascular risk are important and in whom hypoglycemia should be avoided.
Controversial Terminology
2017-09-21

In recent years, research on the concept of ‘empire’ has seen an upswing of interest in both Political Science and History. Definitions of ‘empire’ abound, as they do for words such as ‘discourse’, ‘performance’ and ‘culture’. Countless books and edited volumes concerning questions of ‘empire’ have been published since the turn of the century. On the most general level, however, the majority of studies on questions of ‘empire’ tend to neglect the European Middle Ages. Medievalists continue to associate the Latin terms imperium and imperator primarily with the (Holy) Roman Empire. A closer examination of the existing material in Latin and the vernacular languages reveals that many late medieval authors were far from limited in their use of imperial terminology. This introductory essay establishes the historiographical context for an exploration of this terminology as it was employed in the Latin West in two instances. The first is imperial self-designation, cases where rulers explicitly adopted or avoided the language of empire in referring to themselves or their realms. The second is the use of imperial terminology by authors from Latin Europe to describe and characterise distant and foreign regions of the world.
The ‘Emperor of Persia’
2017-09-21

From the late eleventh century onwards, the crusades brought Latin Christianity into direct contact with Muslim powers in the Near East. For the chroniclers of these events, the task of coping with the diversity of different Muslim actors the Christians faced was extremely challenging. Basically, they had two options to describe their respective political order: they could either use the rulers’ titles in the version supplied by the original language (i.e., sultan or caliph) or they could refer to them by using Latin terms (i.e., rex or imperator). An analysis of the way in which different crusade chroniclers described the political landscape of Islam in the Near East reveals interesting insights: ethnic denominations such as ‘Turks’ or ‘Saracens’ alternated with classical terms such as ‘Babylonians’ and ‘Persians’ thereby evoking ancient empires that were part of the medieval theory of translatio imperii. The Seljuk Sultan, for example, was frequently presented as the ‘emperor of Persia’. Thus, the Muslim states of the eleventh and twelfth centuries were at least to some extent presented as being part of the historical process of evolving and declining empires. The present article asks first how different chroniclers coped with the difficulty of naming and defining foreign political orders and thus developed distinctive interpretations of the history of these empires. Second, the article traces the way in which these models could be adopted by ‘non-crusade’ historiography: the example of William of Malmesbury shows that the English chronicler used the account by Fulcher of Chartres, but developed a remarkably distinctive version. Underlying his accounts is an overall theory of a continuing presence of eastern empires against the changing nature of politics in Christian Europe.
Spontaneous reoccurrence of “scooping”, a wild tool-use behaviour, in naïve chimpanzees
2017-09-22

Modern human technological culture depends on social learning. A widespread assumption for chimpanzee tool-use cultures is that they, too, are dependent on social learning. However, we provide evidence to suggest that individual learning, rather than social learning, is the driver behind determining the form of these behaviours within and across individuals. Low-fidelity social learning instead merely facilitates the reinnovation of these behaviours, and thus helps homogenise the behaviour across chimpanzees, creating the population-wide patterns observed in the wild (what here we call “socially mediated serial reinnovations”). This is the main prediction of the Zone of Latent Solutions (ZLS) hypothesis. This study directly tested the ZLS hypothesis on algae scooping, a wild chimpanzee tool-use behaviour. We provided naïve chimpanzees ( n = 14, Mage = 31.33, SD = 10.09) with ecologically relevant materials of the wild behaviour but, crucially, without revealing any information on the behavioural form required to accomplish this task. This study found that naïve chimpanzees expressed the same behavioural form as their wild counterparts, suggesting that, as the ZLS theory predicts, individual learning is the driver behind the frequency of this behavioural form. As more behaviours are being found to be within chimpanzee’s ZLS, this hypothesis now provides a parsimonious explanation for chimpanzee tool cultures.
Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis
2017-09-22

Objective— Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes responds to viruses, tumor cells, and other pathogens to aid in protection of the host. In this study, we wished to determine how early atherogenesis impacts NCM patrolling in the vasculature. Approach and Results— To study the role of NCM in early atherogenesis, we quantified the patrolling behaviors of NCM in ApoE −/− (apolipoprotein E) and C57BL/6J mice fed a Western diet. Using intravital imaging, we found that NCM from Western diet–fed mice display a 4-fold increase in patrolling activity within large peripheral blood vessels. Both human and mouse NCM preferentially engulfed OxLDL (oxidized low-density lipoprotein) in the vasculature, and we observed that OxLDL selectively induced NCM patrolling in vivo. Induction of patrolling during early atherogenesis required scavenger receptor CD36, as CD36 −/− mice revealed a significant reduction in patrolling activity along the femoral vasculature. Mechanistically, we found that CD36-regulated patrolling was mediated by a SFK (src family kinase) through DAP12 (DNAX activating protein of 12KDa) adaptor protein. Conclusions— Our studies show a novel pathway for induction of NCM patrolling along the vascular wall during early atherogenesis. Mice fed a Western diet showed increased NCM patrolling activity with a concurrent increase in SFK phosphorylation. This patrolling activity was lost in the absence of either CD36 or DAP12. These data suggest that NCM function in an atheroprotective manner through sensing and responding to oxidized lipoprotein moieties via scavenger receptor engagement during early atherogenesis.
Black hole evaporation in conformal gravity
2017-09-22

We study the formation and the evaporation of a spherically symmetric black\\nhole in conformal gravity. From the collapse of a spherically symmetric thin\\nshell of radiation, we find a singularity-free non-rotating black hole. This\\nblack hole has the same Hawking temperature as a Schwarzschild black hole with\\nthe same mass, and it completely evaporates either in a finite or in an\\ninfinite time, depending on the ensemble. We consider the analysis both in the\\ncanonical and in the micro-canonical statistical ensembles. Last, we discuss\\nthe corresponding Penrose diagram of this physical process.\\n
Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
2017-09-22

As prolonged cardiopulmonary bypass becomes more essential during cardiac interventions, an increasing clinical demand arises for procedure optimization and for minimizing organ damage resulting from prolonged extracorporal circulation. The goal of this paper was to demonstrate a fully functional and clinically relevant model of cardiopulmonary bypass in a mouse. We report on the device design, perfusion circuit optimization, and microsurgical techniques. This model is an acute model, which is not compatible with survival due to the need for multiple blood drawings. Because of the range of tools available for mice (e.g., markers, knockouts, etc.), this model will facilitate investigation into the molecular mechanisms of organ damage and the effect of cardiopulmonary bypass in relation to other comorbidities.