julilili42/papers huggingface dataset:
A Network Substrate for Peer-to-Peer Grid Computing beyond Embarrassingly Parallel Applications
2009-01-01

Embarrassingly parallel grid applications require no inter-worker interaction. Thus, the underlying communication infrastructure is based on the simple but well understood client/server execution model. This is no longer sufficient if more demanding parallel applications that require true peer-to-peer interaction are to be deployed on grids. In this paper, we propose the industrial-strength eXtensible Messaging and Presence Protocol (XMPP) as a network substrate for these non-trivial peer-to-peer grid computing applications.
Effect of anticoagulation therapy on bleeding and thromboembolic events (TEs) in the AVADO phase III study of docetaxel (D) ± bevacizumab (BV) in inoperable locally recurrent (LR) or metastatic breast cancer (mBC).
2009-01-01

Abstract Abstract #1035 Background: In first-line mBC, the anti-VEGF monoclonal antibody BV (Avastin®) has demonstrated PFS improvement when combined with taxanes in two large phase III trials (E2100 and AVADO). Thromboses and bleeding are among the possible side effects of BV. Pts receiving full-dose anticoagulation therapy have historically been excluded from clinical trials of BV due to the hypothetical risk of bleeding and TEs. AVADO enrolled pts receiving full-dose anticoagulation provided that their level of anticoagulation was stable for ≥2 weeks prior to study entry. We investigated the incidence of bleeding and arterial and venous TEs (ATEs; VTEs) in pts receiving concomitant anticoagulation therapy in AVADO.&amp;#x2028; Methods: Pts with inoperable LR or mBC, with no CTx 6 months prior to randomisation (12 months if taxane-based), ECOG PS 0–1 and adequate LVEF were eligible for enrolment. 736 pts were randomised to D 100mg/m2 + placebo (PL) or D + BV 7.5 or 15mg/kg. D was administered q3w for ≥9 cycles, BV/PL q3w until disease progression or unacceptable toxicity. Anticoagulation therapy was defined as coumarin, heparin or low molecular weight heparins.&amp;#x2028; Results: Safety data are available from 730 pts. Grade ≥3 TEs and grade ≥3 bleeding were each reported by six pts (1.2%) who received BV, compared with nine pts (3.9%) and two pts (0.9%), respectively in the control arm. Eleven pts received anticoagulants at study entry (PL: 4, BV 7.5mg/kg: 6, BV 15mg/kg: 1) and 73 pts began anticoagulants during the study (PL: 21, BV 7.5mg/kg: 26, BV 15mg/kg: 26). No grade ≥3 ATEs were reported in pts receiving anticoagulation therapy either before or during the study.&amp;#x2028; &amp;#x2028; Conclusions: The rate of grade ≥3 ATEs, VTEs and bleeding events was relatively low in the entire study and did not appear to increase with BV use. The incidence of TEs and bleeding events was not increased relative to the control arm in the subpopulation of pts receiving anticoagulants concurrently with BV, although patient numbers are small, particularly for bleeding events. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1035.
GSH, or Granular Solid Hydrodynamics: on the Analogy between Sand and Polymers
2009-01-01

When at rest, sand maintains shear stresses as durably as an elastic medium—see the tilted slopes of a sand dune that persists forever if unperturbed. When being sheared, sand becomes transiently elastic, because grains partially loose contact with one another, during which the elastic stress relaxes. The flip‐flop between permanent and transient elasticity is an important characteristics of granular behavior, and the basis for GSH. A simplified version of this theory is presented here. It successfully accounts for static stresses of different geometries and the rheological behavior in the hypoplastic regime. And we calculate the strain curves of different stress loops, finding it to display realistic forms, including that of a butterfly.
Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. Differences in rhythmical behavior
2009-01-01

We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis.A total of 68 patients with primary BCCs and 40 patients with PP were included in the study. LDF time series were separated in four scaling levels corresponding to the influences of sympathetic activity (SL1), myogenic activity in the vessel wall (SL2), respiration (SL3) and heart beat (SL4).In BCC, SL1 decreased compared to healthy skin. In all other scaling levels, we found a statistically significant increase of the SLs compared to healthy skin. These increases were not found in PP.Rhythmical behavior of blood flow in malignant tumors is totally different from that in regions with inflammation. In BCCs, thermoregulatory processes, ascribed to sympathetic activity, decrease statistically significant. In contrast, inflammatory processes in PP do not substantially change sympathetic activity. WA of tumor perfusion could open a new noninvasive monitor system for controlling tumor therapy.
Metal Oxide Gas Sensor Arrays: Geometrical Design and Selectivity
2009-01-01

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Frank Röck, Nicolae Barsan, Udo Weimar; Metal Oxide Gas Sensor Arrays: Geometrical Design and Selectivity. AIP Conf. Proc. 23 May 2009; 1137 (1): 140–143. https://doi.org/10.1063/1.3156492 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Synthesis and Reactions of 5-[Amino(thiomethyl)methylene]- 2,2-dimethyl-1,3-dioxane-4,6-dione
2009-01-01

5-[Amino(thiomethyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione (4) is obtained from 5-[bis- (thiomethyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione (1) and aqueous ammonia in excellent yield. Its reaction with m-chloroperbenzoic acid gives the sulfoxide derivative 5-[amino(sulfinylmethyl) methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione (5). With triphenylphosphine, 5 reacts to give triphenyl( thiomethyl)phosphonium 5-cyano-2,2-dimethyl-1,3-dioxane-4,6-dionate (6) from which the methyltriphenylphosphonium salt 6a is obtained with excess triphenylphosphine. The crystal structures of 4, 5 and 6a are discussed.
Identification and Characterization of Tyrosinase from Streptomyces Albus by Mass Spectrometry
2009-01-01

The bacterium Streptomyces albus has so far never been investigated for tyrosinase activity. The studies presented in this communication show that his bacterium is maybe a future source for larger production of tyrosinase. The enzyme was purified starting with 5 600 ml of culture filtrate. The crude enzyme was first purified by centrifugation, followed by ammonium sulphate precipitation and ultrafiltration. Then, melanin was removed applying a Servacell DEAE 52 resin, using the batch technique. Thereafter, the crude enzyme was loaded on a SEC Sephacryl S-100 column and after ultrafiltration 1.17 mg of purified tyrosinase were obtained. The molecular mass of the purified enzyme was determined by MALDI mass spectrometry to be 30 096 Da which corresponds to the obtained results from SDS-PAGE.Using diphenol L-DOPA and the monophenol L-tyrosine as substrates, the kinetic parameters for both substrates, Km= 7.8 mM and 0.5 mM and Kcat/Km= 157 mM−1s−1 and 23 mM−1s−1, respectively, were determined. Maximal activities of the purified enzyme were recorded at pH 7.0.Several isolated peptides were sequenced by MALDI MS/MS and a spectrum of the peptide with mass 1357.64 was characterized and allowing to deduce the sequence SDRQVTTGPFAYRHG. A spectrum of the peptide with molecular mass 1536.61 was characterized and deduced sequence is WVGGQMATGVSPN. Other spectrum of a peptide with molecular mass 1334.3 gave sequence DTDSGERTGHR. The identified amino acid sequences of the peptides showed very high similarity with database sequences for other tyrosinases from Streptomyces species.
SCAN tools for collaborative learning
2009-01-01

SCAN tools (Social and Cognitive Awareness and Navigation tools) inform participants about social and/or cognitive variables with respect to a group and its members. This paper describes how SCAN tools facilitate and "institutionalize" the natural processes of becoming aware about social and cognitive variables, thereby leading to adaptive behavior in collaboration. The notion of person-object relations (PORs) is introduced as the basic building block underlying both group awareness and social navigation. Four design principles of SCAN tools (response formatting, juxtaposition, aggregation/transformation, and prediction/recommendation) are discussed, and their application in CSCL scenarios is described. Finally, issues for both practical implications and use-inspired basic research on SCAN mechanisms will be explored.
Thermodynamic Analysis and Molecular Modeling ofRapana VenosaHemocyanin—Functional Unit RVH2-E
2009-01-01

pH-T diagram is typical “phase portrait” for stability of functional unit RvH2-e. Using different techniques the T-transition curves at different pH for RvH2-e were analyzed and the parameters of the thermodynamic functions were obtained. Increasing temperature and within the T range 25–55°C the reversibility increases and “opens a reversibility window” within the range of pH 5.5–9.0, for which were calculate at standard temperature the thermodynamic functions ΔHo and ΔGoexp.Molecular modeling of correct 3D structure of functional unit RvH2-e was done which allows us to fix most probably position of missing 9 residues now presented in existed x-ray model at very poor resolution of 3.30Å.
Extra-adrenal paravertebral myelolipoma mimicking a thoracic schwannoma
2009-01-01

Myelolipoma of the adrenal gland is composed of both adipose tissue and normal haematopoietic elements. Extra-adrenal myelolipomas are rare. We present the case of a 63-year-old female patient with adenoma of the adrenal gland and an additional paravertebral lesion in the thoracic spine. Previous computed tomography of the lesion covering the nerve roots in the right T8–T9 foramina was compatible with a schwannoma. Post-mortem histopathology showed the incidental finding of a paravertebral myelolipoma.
SySifoS
2009-01-01

In this paper, we describe a prototyping platform for wireless networking devices. The simulator modules constitute a virtual communication network which can be used for architecture analysis, functional verification and software development at an early stage of system design. The simulator enables the easy and efficient development of application software. We use the simulator for the construction of an exemplary Bluetooth location system. By modeling physical effects like radio signal propagation our simulator is capable of evaluating the performance of distributed applications in a wireless network under real world constraints.
A categorical quotient in the category of dense constructible subsets
2009-01-01

A. A'Campo-Neuen and J. Hausen gave an example of an algebraic torus action on an open subset of the affine four space that admits no quotient in the category of algebraic varieties. We show that this example admits a quotient in the category of dense co
Colour in action: Evidence for a redundancy signal effect when driving motor responses by combined colour and spatial cues.
2009-01-01

Several studies have demonstrated that either chromatic or spatial information can guide motor behaviour, but so far interactions between these two visual features are little understood.Here we addressed this issue by measuring reaction times (RT) for pointing hand movements which were instructed by either cues for spatial (thought to be predominantly processed in the dorsal visual stream), colour (thought to be predominantly processed in the ventral visual stream) or redundant (combination of colour and spatial information) conditions.While faster responses were found for spatial than for colour cues, most importantly, the shortest RTs were measured for the combined cues (redundancy signal effect, RSE).The data are inconsistent with the predictions of the race model which assumes parallel and independent input from the two streams to the motor system.Instead, the data are better explained by the coactivation model, which proposes combined sensory information from the different stimuli and detection process from the sum of the signals.Here, the redundancy signal effect results from the combination of colour and spatial information.The results provide behavioural evidence for an integration of colour and spatial cues when guiding hand movements.
Comparison between circulating and disseminated tumor cells in breast cancer.
2009-01-01

Abstract Abstract #301 Background: The presence of disseminated tumor cells (DTC) in the bone marrow (BM) of breast cancer patients is an independent prognostic factor. The role of circulating tumor cells (CTC) in blood is not yet defined. Since BM aspiration is less accepted by patients compared to blood drawing, it would be highly desirable to replace BM aspiration by blood analysis. Therefore, the purpose of the present study was: (1) to examine the presence of CTC in peripheral blood (2) to assess the correlation between CTC in blood and DTC in BM and (3) since adjuvant therapy targets minimal residual disease (MRD), to compare the expression profile of therapeutic relevant markers between CTC (a potential surrogate marker for MRD) and the primary tumor.&amp;#x2028; Materials and Methods: 282 blood samples from primary breast cancer patients were collected. All samples underwent immunomagnetic enrichment using the AdnaTest BreastCancerSelect (AdnaGen AG, Germany) within 4 hours after blood withdrawal followed by RNA isolation and subsequent gene expression analysis by reverse transcription and Multiplex-PCR in separated tumor cells using the AdnaTest BreastCancerDetect. CTC were analyzed for the three breast cancer associated markers: GA733-2, Muc-1, Her-2 and β–actin as an internal PCR control. Expression of the estrogen (ER) and progesterone (PR) receptor was assessed in an additional RT-PCR. The analysis of PCR products was performed by capillary electrophoresis on the Agilent Bioanalyzer 2100. Furthermore, two BM aspirates from each of these patients were analyzed by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3. Evaluation of DTC was performed with the ACIS system (Chromavision) and the ARIOL system (Applied Imaging) according to the ISHAGE evaluation criteria.&amp;#x2028; Results: 282 patients could be included into this study. 44/282 (16%) of these patients had detectable CTC in the bloodstream. BM samples could be analyzed in 267/282 patients. DTC were found in 64/267 patients, resulting in a positivity rate for DTC in the BM of 23%. BM status did not correlate with the presence of CTC (p=0.112) supporting the theory of different clinical relevance. MUC-1 and GA 73.3 were expressed by 57% and 61% of the CTC, respectively. CTC were HER2 positive in 39% of patients whereas only 11% of the corresponding primary tumor overexpressed HER2. Most of the patients had ER und PR positive tumors (84% and 73%, respectively). However, the majority of the CTC were ER and PR negative (75% and 98%, respectively).&amp;#x2028; Conclusions: (1) These data indicate that due to the discordance between CTC and DTC the clinical relevance may be different. (2) The expression profile between CTC (a possible surrogate marker for MRD) and the primary tumor (the current gold standard for selecting targeted therapy against MRD) differs. Thus, the consequence for selecting HER2 targeted or anti - endocrine therapy has to be evaluated. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 301.
Prompt Gamma Rays in [sup 77]Ge after Neutron Capture on [sup 76]Ge
2009-01-01

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Georg Meierhofer, Lea Canella, Peter Grabmayr, Josef Jochum, Jan Jolie, Petra Kudejova, Nigel Warr; Prompt Gamma Rays in 77Ge after Neutron Capture on 76Ge. AIP Conf. Proc. 28 January 2009; 1090 (1): 559–563. https://doi.org/10.1063/1.3087085 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A scholarly confusion of tongues, or, is promising an illocutionary act?
2009-01-01

Technical terms, I argued elsewhere, should not be re-defined without a profound reason; for such a re-definition furthers misunderstanding and is therefore undesirable.If my argument is on the right track, then we have reason to acknowledge the original definition of 'illocutionary acts' established by John L. Austin; any subsequent re-definition, unless it is specially justified somehow, must count as a terminological mistake.I use this argument, in order to proceed against what appears to me a highly problematic terminological situation, namely, the present existence of a double-digit number of different definitions of the term "illocutionary act."Against my argument, I met the objection that the co-existence of several different intensional definitions of 'illocutionary acts' eventually is not very problematic, given the alleged fact that the extension of the term is indisputable.In this paper, I argue that the objection fails, because its central premise is false: William P. Alston (2000), Bach & Harnish (1979) and John R. Searle (1969) have very different opinions as to whether, for instance, promising is an illocutionary act, even though promises are commonly supposed to be extremely obvious cases.Additionally, I consider the objection that the term "illocutionary act" is indispensable as a means of referring to those various things it is used for; I discard this objection by demonstrating that, and how, at least the accounts under consideration in this paper could easily do without the term.
Stem cell and epithelial-mesenchymal transition markers on circulating tumor cells in patients with metastatic breast cancer.
2009-01-01

Abstract Abstract #107 Background: Stem cell like tumor cells have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, these cells may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment. Assuming that metastasis requires a dissemination of tumor stem cells or tumor cells showing EMT, it was the purpose of this study to identify these cells among circulating tumor cells (CTC) in blood samples of 28 metastatic breast cancer patients.&amp;#x2028; Materials and Methods: 5 ml blood was analyzed for EpCAM, MUC-1 and HER-2 transcripts with the AdnaTest BreastCancer (AdnaGen AG). The recovered c-DNA was additionally multiplex tested for three EMT markers [Twist, Akt2, PI3K (TAP)] and separately for the tumor stem-cell marker ALDH1. The analytical sensitivity was determined by the detection of a low number of target cells (5 IGROV cells spiked into 5 ml blood of healthy donors) using the AdnaTest BreastCancer procedure. The identification of EMT markers was considered positive if at least one marker was detected in the sample. Healthy donor samples without spiked tumor cells were used to determine the specificity of the test. The resulting PCR fragments were separated and quantified using the Agilent Bioanalyzer 2100.&amp;#x2028; Results: Applying an amplicon cut-off value of 0.2 ng/μl for Akt2, 0.15 ng/μl for Twist, 0.25 ng/μl for PI3K and 0.15 ng/μl for ALDH1, 97% of 30 healthy donor samples investigated were negative for TAP and 95% for ALDH1 transcripts. The spiking experiments revealed 80% recovery of the IGROV cells. CTC were detected in 12/28 (43%) breast cancer samples. All samples were further examined for tumor stem cell or TAP markers. In the CTC (+) group 50% were positive for at least one of the TAP markers and 42% for ALDH1. In the CTC (-) group the percentages were 19% and 12%, respectively. The expression of TAP and/or stem cell markers in CTC was compared with the clinical follow up results. In CTC (+) patients diagnosed as non-responders the expression of TAP and ALDH1 was found in 5/12 (40%) samples. In the CTC (+) responder group only one sample expressed TAP and no positive case was found for ALDH1. In the CTC (-) non-responder group 1/14 samples was positive for TAP and ALDH1. 2/14 (14%) of CTC (-) responders were positive for TAP and 1/14 for ALDH1, respectively.&amp;#x2028; Conclusion: A major proportion of CTC found in the blood of metastatic breast cancer patients shows EMT and tumor stem cell characteristics supporting the hypothesis that these markers are an indicator for therapy resistant tumor cell populations and, therefore, for an inferior prognosis. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 107.
Positioning for conceptual development using latent semantic analysis
2009-01-01

With increasing opportunities to learn online, the problem of positioning learners in an educational network of content offers new possibilities for the utilisation of geometry-based natural language processing techniques.
Special Section: Phylogenetics
2009-01-01

Phylogenetics is the reconstruction and analysis of trees and networks to describe and understand the evolution of species, populations, and individuals. It is fundamental to evolutionary biology and finds applications in other areas of classification, such as linguistics. Although the foundations of phylogenetics were laid down many decades ago, it is currently experiencing an exciting renaissance due to the wealth and types of biological data that are now becoming available.
Thrombosis as a complication of the Klippel-Trénaunay syndrome and other vascular malformations
2009-01-01

Summary The Klippel-Trénaunay syndrome (KTS) is a congenital disorder of vascular malformations characterized by the clinical trias of naevi flammei, varicosis and hypertrophy of the affected limb. According to its clinical development KTS can be diagnosed directly post partum or becomes apparent in the course of the development particularly regarding incomplete forms. The most described symptoms next to swelling are pain and augmented sweating of the affected extremity. Complications of KTS are bleeding from mechanically traumatised vascular malformations or widened vessels, but also thromboembolic events are reported. We report on two patients with KTS and one patient with angiodysplasia, who developed deep vein thromboses in the affected limb at young age. None of the patients suffered from thrombophilia or other predisposing risk factors for thrombosis. KTS and other angiodysplastic disorders seem to be a risk factor for thromboembolic complications even at young age. A comprehensive counceling of the patients concerning the prevention of complications and especially the symptoms of thromboembolic events is important for early diagnosis and immediate therapy.