julilili42/papers huggingface dataset:
Land use dynamics derived from colluvial deposits and bogs in the Black Forest, Germany
2017-12-12

Abstract The Black Forest is considered to be a rather unfavorable area, having a short vegetation period, low mean annual temperatures, high precipitation, and a pronounced relief. These conditions do not favor agricultural land use and thus it is widely accepted that people only began using the land intensively during the Middle Ages. In this integrated study 17 soil profiles, two peat bogs and a database of archaeological finds were used to reconstruct past land use impacts on the environment. AMS– 14 C datings of charcoals, luminescence datings of colluvial deposits, archaeological finds and pollen records indicate land use already during the Neolithic. This pre‐medieval land use might be related to seasonal settlements dominated by pastoralism and the use of wood or bedrock to build settlements and infrastructure or as energy supply. There is new evidence of human activity dating back to the Bronze and Iron Age, which is a discrepancy to the absence of archaeological finds in the direct vicinity of the studied sites. With the beginning of the Middle Ages land use practices changed, most likely with the expansion and intensification of agricultural land use, which coincides with the increasing use of natural resources in the Black Forest. Hence, the main phases of colluvial deposition date to the Middle Ages and Modern Times. Increased contents of As, Cr, Cu, Pb, or Zn in medieval colluvial deposits might indicate smelting or mining, even though there are no known archeological sites pointing to such activities nearby. Whereas the pattern of colluvial deposition in the southeastern Black Forest points to distinct, but local land use in pre‐medieval times and to intensified and widespread land use since the Middle Ages, thick and multi‐layered colluvial deposits indicate intensive land use in the neighboring Baar region since the Neolithic. The different land use patterns of these two regions originate from the rather favorable conditions for agriculture in terms of soils, climate, and topography in the Baar region compared to the unfavorable conditions in the Black Forest.
Anatomical Analysis of the Retinal Specializations to a Crypto-Benthic, Micro-Predatory Lifestyle in the Mediterranean Triplefin Blenny Tripterygion delaisi
2017-12-12

The environment and lifestyle of a species are known to exert selective pressure on the visual system, often demonstrating a tight link between visual morphology and ecology. Many studies have predicted the visual requirements of a species by examining the anatomical features of the eye. However, among the vast number of studies on visual specializations in aquatic animals, only a few have focused on small benthic fishes that occupy a heterogeneous and spatially complex visual environment. This study investigates the general retinal anatomy including the topography of both the photoreceptor and ganglion cell populations and estimates the spatial resolving power (SRP) of the eye of the Mediterranean triplefin <i>Tripterygion delaisi</i>. Retinal wholemounts were prepared to systematically and quantitatively analyze photoreceptor and retinal ganglion cell (RGC) densities using design-based stereology. To further examine the retinal structure, we also used magnetic resonance imaging (MRI) and histological examination of retinal cross sections. Observations of the triplefin's eyes revealed them to be highly mobile, allowing them to view the surroundings without body movements. A rostral aphakic gap and the elliptical shape of the eye extend its visual field rostrally and allow for a rostro-caudal accommodatory axis, enabling this species to focus on prey at close range. Single and twin cones dominate the retina and are consistently arranged in one of two regular patterns, which may enhance motion detection and color vision. The retina features a prominent, dorso-temporal, convexiclivate fovea with an average density of 104,400 double and 30,800 single cones per mm<sup>2</sup>, and 81,000 RGCs per mm<sup>2</sup>. Based on photoreceptor spacing, SRP was calculated to be between 6.7 and 9.0 cycles per degree. Location and resolving power of the fovea would benefit the detection and identification of small prey in the lower frontal region of the visual field.
Superhumps linked to X-ray emission
2017-12-12

Context. We present more than 4 years of Swift X-ray observations of the 2013 superoutburst, subsequent decline and quiescence of the WZ Sge-type dwarf nova SSS J122221.7−311525 (SSS J122222) from 6 days after discovery. Aims. Only a handful of WZ Sge-type dwarf novae have been observed in X-rays, and until recently GW Lib was the only binary of this type with complete coverage of an X-ray light curve throughout a superoutburst. We collected extensive X-ray data of a second such system to understand the extent to which the unexpected properties of GW Lib are common to the WZ Sge class. Methods. We collected 60 Swift -XRT observations of SSS J122222 between 2013 January 6 and 2013 July 1. Four follow-up observations were performed in 2014, 2015, 2016 and 2017. The total exposure time of our observations is 86.6 ks. We analysed the X-ray light curve and compared it with the behaviour of superhumps which were detected in the optical light curve. We also performed spectral analysis of the data. The results were compared with the properties of GW Lib, for which new X-ray observations were also obtained. Results. SSS J122222 was variable and around five times brighter in 0.3–10 keV X-rays during the superoutburst than in quiescence, mainly because of a significant strengthening of a high-energy component of the X-ray spectrum. The post-outburst decline of the X-ray flux lasted at least 500 d. The data show no evidence of the expected optically thick boundary layer in the system during the outburst. SSS J122222 also exhibited a sudden X-ray flux change in the middle of the superoutburst, which occurred exactly at the time of the superhump stage transition. A similar X-ray behaviour was also detected in GW Lib. Conclusions. We show that the X-ray flux exhibits changes at the times of changes in the superhump behaviour of both SSS J122222 and GW Lib. This result demonstrates a relationship between the outer disc and the white dwarf boundary layer for the first time, and suggests that models for accretion discs in high mass ratio accreting binaries are currently incomplete. The very long decline to X-ray quiescence is also in strong contrast to the expectation of low viscosity in the disc after outburst.
The role of discourse in family policy reform: The case of Finland
2017-12-12

Since 2010 and the onset of the economic crisis, Finnish governments have pressed for structural reforms, including unpopular cuts to family benefits and services. This article analyses the government discourse used for legitimating some of these reforms: the cutbacks in child benefit and the restriction of full-time childcare. It also assesses whether this discourse bore the hallmarks of a neoliberal austerity discourse, which could suggest that the reforms were not just a matter of fiscal balancing but also a matter of neoliberal welfare state restructuring. We argue that the economic crisis was central in the powerful ‘communicative’ discourse used by the governments for legitimating unpopular cuts. Not only did it draw on ideas from an austerity discourse advocating financial sustainability, fiscal prudency and debt reduction, it was also impregnated with ideas from a neoliberal worldview questioning some of the main principles of the ‘Nordic’ family policy model.
Cue Reactivity Essentials: Event-Related Potentials During Identification of Visual Alcoholic Stimuli in Social Drinkers
2017-12-12

Objective: Cue reactivity is an automatic reaction to alcohol-related cues, contributing to the maintenance of drinking behavior and relapse in alcohol dependency. The identification of valid cue-reactivity features is a prerequisite for its clinical application. We were interested in the effects of visual features of alcohol cues (e.g., color) on cue reactivity. Assuming its development at a pre-pathological stage, we analyzed cue reactivity in heavy social drinkers, with light social drinkers as controls. We investigated whether cue reactivity was independent of visual features at an attentional (P100) and a motivational level (late positive potential, LPP). Method: Event-related potentials (ERPs; P100, LPP) were analyzed during a visual beverage classification task in heavy social drinkers and light social drinkers (N = 34 university students). Photographs of beverages were classified as alcoholic or nonalcoholic. Two additional stimulus sets depicted unrecognizable scrambled visual information and recognizable black silhouettes of the original beverages. Analysis of contrast waves inferred content (unrecognized scrambled trials subtracted from original) and color information (recognized shape trials subtracted from original) during visual processing. Linear regression was used to predict Alcohol Use Disorders Identification Test (AUDIT) scores from ERPs. Results: In heavy social drinkers, alcoholic-content LPP was increased and P100 latency was shorter compared with nonalcoholic cues. Linear regression for alcohol content condition in the overall sample revealed shorter P100 latency and increased LPP amplitude predicting AUDIT scores. None of those effects were significant in the visual-feature control condition. Conclusions: Alcohol cue reactivity in heavy social drinkers was related to faster early attentional processes and motivational salience. The effect occurred independently of visual features in the pictures.
Heat shock protein 70 and tumor‐infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG)
2017-12-13

Tumor cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface, where it can be recognized by pre‐activated NK cells. In our retrospective study the expression of Hsp70 was determined in relation to tumor‐infiltrating CD56 + NK cells in formalin‐fixed paraffin embedded (FFPE) tumor specimens of patients with SCCHN ( N = 145) as potential indicators for survival and disease recurrence. All patients received radical surgery and postoperative cisplatin‐based radiochemotherapy (RCT). In general, Hsp70 expression was stronger, but with variable intensities, in tumor compared to normal tissues. Patients with high Hsp70 expressing tumors (scores 3–4) showed significantly decreased overall survival (OS; p = 0.008), local progression‐free survival (LPFS; p = 0.034) and distant metastases‐free survival (DMFS; p = 0.044), compared to those with low Hsp70 expression (scores 0–2), which remained significant after adjustment for relevant prognostic variables. The adverse prognostic value of a high Hsp70 expression for OS was also observed in patient cohorts with p16‐ ( p = 0.001), p53‐ ( p = 0.0003) and HPV16 DNA‐negative ( p = 0.001) tumors. The absence or low numbers of tumor‐infiltrating CD56 + NK cells also correlated with significantly decreased OS ( p = 0.0001), LPFS ( p = 0.0009) and DMFS ( p = 0.0001). A high Hsp70 expression and low numbers of tumor‐infiltrating NK cells have the highest negative predictive value ( p = 0.00004). In summary, a strong Hsp70 expression and low numbers of tumor‐infiltrating NK cells correlate with unfavorable outcome following surgery and RCT in patients with SCCHN, and thus serve as negative prognostic markers.
Effectiveness of a “Grass Roots” Statewide Enrichment Program for Gifted Elementary School Children
2017-12-13

Enrichment programs provide learning opportunities for a broader or deeper examination of curricular or extracurricular topics and are popular in gifted education. Herein, we investigated the effectiveness of a statewide extracurricular enrichment program for gifted elementary school children in Germany. The program implemented a ”grass roots“ strategy by which local units developed and offered the enrichment courses, which spanned a broad array of topics. The courses targeted different outcomes, including students' cognitive abilities, school achievement, interests, creativity, self-control, self-concept, and social competencies. We compared third-grade students attending the enrichment program (N =423) with nonattending third-grade students (N = 2,328) by means of a propensity score analysis. Specifically, we controlled for potential selection effects and estimated the average causal effect of the enrichment program for children attending the program. The findings revealed positive program effects on academic achievement but not on the other targeted outcomes.
Towards a theoretical clarification of biomimetics using conceptual tools from engineering design
2017-12-13

Many successful examples of biomimetic products are available, and most research efforts in this emerging field are directed towards the development of specific applications. The theoretical and conceptual underpinnings of the knowledge transfer between biologists, engineers and architects are, however, poorly investigated. The present article addresses this gap. We use a 'technomorphic' approach, i.e. the application of conceptual tools derived from engineering design, to better understand the processes operating during a typical biomimetic research project. This helps to elucidate the formal connections between functions, working principles and constructions (in a broad sense)-because the 'form-function-relationship' is a recurring issue in biology and engineering. The presented schema also serves as a conceptual framework that can be implemented for future biomimetic projects. The concepts of 'function' and 'working principle' are identified as the core elements in the biomimetic knowledge transfer towards applications. This schema not only facilitates the development of a common language in the emerging science of biomimetics, but also promotes the interdisciplinary dialogue among its subdisciplines.
Interactive Light Stimulus Generation with High Performance Real-Time Image Processing and Simple Scripting
2017-12-13

Light stimulation with precise and complex spatial and temporal modulation is demanded by a series of research fields like visual neuroscience, optogenetics, ophthalmology, and visual psychophysics. We developed a user-friendly and flexible stimulus generating framework (GEARS GPU-based Eye And Retina Stimulation Software), which offers access to GPU computing power, and allows interactive modification of stimulus parameters during experiments. Furthermore, it has built-in support for driving external equipment, as well as for synchronization tasks, via USB ports. The use of GEARS does not require elaborate programming skills. The necessary scripting is visually aided by an intuitive interface, while the details of the underlying software and hardware components remain hidden. Internally, the software is a C++/Python hybrid using OpenGL graphics. Computations are performed on the GPU, and are defined in the GLSL shading language. However, all GPU settings, including the GPU shader programs, are automatically generated by GEARS. This is configured through a method encountered in game programming, which allows high flexibility: stimuli are straightforwardly composed using a broad library of basic components. Stimulus rendering is implemented solely in C++, therefore intermediary libraries for interfacing could be omitted. This enables the program to perform computationally demanding tasks like en-masse random number generation or real-time image processing by local and global operations.
Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins
2017-12-14

An extra sugar protects Many microbial pathogens produce proteins that are toxic to the cells that they are targeting. Broad-leaved plants are susceptible to NLP (necrosis and ethylene-inducing peptide 1–like protein) toxins. Lenarčič et al. identified the receptors for NLP toxins to be GIPC (glycosylinositol phosphorylceramide) sphingolipids (see the Perspective by Van den Ackerveken). Their findings reveal why these toxins only attack broad-leaved plants (so-called eudicots): If the sphingolipid carries just two hexoses, as is the case for eudicots, the toxin binds and causes cell lysis. But in monocots with sphingolipids that have three hexoses, the toxin is ineffective. Science , this issue p. 1431 ; see also p. 1383
Influence of Age and Other Factors on Cytokine Expression Profiles in Healthy Children—A Systematic Review
2017-12-14

Cytokines have attracted much attention as diagnostic biomarkers for infectious and inflammatory diseases in recent years. However, understanding of maturation and normal age-associated values is limited. This review summarizes evidence on the influence of age and other factors on expression profiles of soluble and intracellular cytokines in healthy children. IFN-γ, IL-6, IL-10, and TNF-α are the most frequently investigated cytokines, of which an age-associated increase was shown consistently for IFN-γ and TNF-α. An age-associated decrease of IL-13 was seen in resource-limited settings. For other cytokines, including IL-1RA, IL-2, and IL-10, uni- or bimodal curves have been described, and results were influenced by study setting. To conclude, despite limited current understanding of the development of cytokine expression, age clearly influences expression profiles in healthy children. Dynamics of cytokine expression in childhood need to be considered when these are measured in diagnostic assays or as biomarkers. In addition, cytokine-targeting agents may require adjustment for normal values when used in children.
The evolution of young HII regions
2017-12-14

Context. High-mass stars form in much richer environments than those associated with isolated low-mass stars, and once they reach a certain mass, produce ionised (H II ) regions. The formation of these pockets of ionised gas are unique to the formation of high-mass stars ( M &gt; 8 M ⊙ ), and present an excellent opportunity to study the final stages of accretion, which could include accretion through the H II region itself. Aim. This study of the dynamics of the gas on both sides of these ionisation boundaries in very young H II regions aims to quantify the relationship between the H II regions and their immediate environments. Methods. We present high-resolution (~0.5′′) ALMA observations of nine H II regions selected from the red MSX source survey with compact radio emission and bolometric luminosities greater than 10 4 L ⊙ . We focus on the initial presentation of the data, including initial results from the radio recombination line H29 α , some complementary molecules, and the 256 GHz continuum emission. Results. Of the six (out of nine) regions with H29 α detections, two appear to have cometary morphologies with velocity gradients across them, and two appear more spherical with velocity gradients suggestive of infalling ionised gas. The remaining two were either observed at low resolution or had signals that were too weak to draw robust conclusions. We also present a description of the interactions between the ionised and molecular gas (as traced by CS (J = 5 − 4)), often (but not always) finding the H II region had cleared its immediate vicinity of molecules. Conclusions. Of our sample of nine, the observations of the two clusters expected to have the youngest H II regions (from previous radio observations) are suggestive of having infalling motions in the H29 α emission, which could be indicative of late stage accretion onto the stars despite the presence of an H II region.
Coronary and carotid atherosclerosis in asymptomatic male marathon runners
2017-12-14

The aim of the study was to evaluate the diagnostic accuracy of carotid ultrasound ( CU ) to predict coronary atherosclerosis in asymptomatic male marathon runners. A total of 49 male marathon runners older than 45 years (mean age 53.3 ± 7.2 years, range 45‐74 years) received CU and cardiac CT angiography ( CTA ) including calcium scoring ( CS ). Results of CU and CTA were classified binary: 1. Absence of atherosclerosis and 2. Presence of atherosclerosis. The extent of atherosclerosis was not primary end point of the study. Mean PROCAM score was 2.3% ( SD 2.2, range 0.44%‐12.34%). One person had to be excluded from analysis (one missing CT ‐scan). From the remaining 48 marathon runners, 17 (35.4%) had carotid atherosclerosis and 22 (45.8%) coronary atherosclerosis. Atherosclerosis in either exam was diagnosed in 27/48 (56.3%) marathon runners. Diagnostic accuracy of CU to predict coronary atherosclerosis was: sensitivity 54.55% (95% CI 32.2‐75.6), specificity 80.8% ( CI 60.6‐93.4), positive predictive value 70.6 ( CI 44.1‐89.9), negative predictive value 67.7 ( CI 48.6‐83.3) with a positive likelihood ratio of 2.84 ( CI 1.18‐6.82) and a negative likelihood ratio of 0.56 ( CI 0.34‐0.92). Coronary and/or carotid atherosclerosis can be detected in more than 50% of male marathon runners aged older than 45 years. The diagnostic value of carotid ultrasound to predict coronary atherosclerosis is low but higher than the accuracy of rest‐ or stress‐ ECG . As outcome studies in sportsmen are still missing, the routine evaluation of the carotid arteries by ultrasound or even cardiac CT cannot be recommended at present. Furthermore, the incidence of atherosclerosis by our method in normal population is not known.
Selective effects of temperature on body mass depend on trophic interactions and network position
2017-12-14

Abstract Body mass is a key trait constraining interspecific interactions in food webs through changes in metabolic requirements. Because climate warming affects metabolic rates, it creates direct selective effects on body mass. Many empirical studies suggest that body mass decreases under warming, although important exceptions have been noted. We first analyze the evolution of body mass in a simple consumer-resource model to provide conditions under which a body mass increase or decrease may be expected. We then extend our model to a multi-trophic food web context that allows for the coevolution of body mass and of feeding preferences. We focus here on how the trophic position of a consumer influences its evolutionary response to warming under different scenarios for the temperature dependence of attack rates. We observe that body masses can remain constant or increase with temperature when attack rates are constant or increasing with temperature, while body mass reductions in response to warming are only expected when attack rates have a thermal optimum and populations are initially locally adapted. We also found that body masses at lower trophic levels vary less under warming than body masses at higher trophic levels, which may be explained by decreasing levels of stabilizing selection along food chains.
Metastatic Lung Adenocarcinoma Mimicking an En-Plaque Meningioma: Case Report
2017-12-14

Dural based lesions in the cranium may result secondary to benign or malignant pathology that may be sometimes difficult to differentiate on imaging.Detailed clinical evaluation and high index of suspicion in many cases will narrow the differential diagnosis.We report an extremely rare case of lung adeno-carcinoma metastasis to brain which appeared as an En-plaque meningioma on neuro-imaging.A benign-appearing duralbased en-plaque lesion may be a manifestation of an underlying malignancy, and a thorough clinical and radiological examination is mandatory to avoid misdiagnosis