julilili42/papers huggingface dataset:
Discovery of Gravity‐Mode Pulsators among Subdwarf B Stars: PG 1716+426, the Class Prototype
2004-05-17

A new class of pulsating subdwarf B stars has recently been announced by Green and coworkers. Here we present a follow-up paper describing our observations and the pulsation structure of the class prototype PG 1716+426. The oscillations are multiperiodic with periods between 0.8 and 1.4 hr (180-340 μHz) and semiamplitudes less than 0.2%. We also observe that the periods and amplitudes appear variable, making the pulsation structure of PG 1716 complicated. The periods are an order of magnitude longer than those seen in EC 14026 (sdBV) stars, implying that they are gravity modes rather than pressure modes. As such, they represent a new class of variable star.
Prospective multicenter phase II study of irinotecan as third-line therapy in metastatic colorectal cancer and progression after bolus and infusional 5-fluorouracil
2004-05-17

Irinotecan has proven anti-tumor activity as induction treatment in combination with 5-fluorouracil (5-FU) or as second-line treatment after 5-FU in patients with metastatic colorectal cancer. The aim of the present phase II study was to evaluate irinotecan as third-line chemotherapy in patients with colorectal cancer after sequential treatment with bolus 5-FU followed by an infusional 5-FU regimen. Patients pretreated with bolus 5-FU/folinic acid and the infusional 5-FU/folinic acid regimen were treated with 350 mg/m irinotecan i.v. once every 3 weeks in a multicenter phase II study. Tumor size was measured every cycle and treatment with irinotecan was continued until the occurrence of progressive disease or unacceptable toxicity. A total of 50 pretreated patients were included. Of the 45 evaluable patients, 13.3% [n=6, 95% confidence interval (CI) 5.1-26.8] attained a response (complete/partial response) to treatment lasting 5.6 months (95% CI 4.2-6.3) and in four patients response has been confirmed (8.9%, 95% CI 2.5-21.2). Disease stabilization was noted in 51.1% of the patients (n=23, 95% CI 35.8-66.3). The median duration of response/disease stabilization was 4.2 months (95% CI 3.2-6.0). Median overall survival was 7.9 months (95% CI 6.1-11.1), corresponding to a calculated 1-year survival of 28.3% (95% CI 15.2-41.3). Severe neutropenia occurred in 14% (n=7) and anemia grade III in 6% of the patients (n=3). The most frequent non-hematological toxicity grade III/IV related to treatment was diarrhea in 24% of the patients (n=12), followed by vomiting in 8% (n=4) and constipation as well as infection in two patients each (4%) (evaluable n=50). We conclude single-agent irinotecan is an effective and well-tolerable treatment in pretreated patients with metastatic colorectal cancer after failure of bolus and infusional 5-FU/folinic acid regimens. Elderly patients had the same probability to respond.
Activating Mutation of the Renal Epithelial Chloride Channel ClC-Kb Predisposing to Hypertension
2004-05-18

The chloride channel ClC-Kb is expressed in the basolateral cell membrane of the distal nephron and participates in renal NaCl reabsorption. Loss-of-function mutations of ClC-Kb lead to classic Bartter syndrome, a rare salt-wasting disorder. Recently, we identified the ClC-Kb T481S polymorphism, which confers a strong gain-of-function effect on the ClC-Kb chloride channel. The present study has been performed to explore the prevalence of the mutation and its functional significance in renal salt handling and blood pressure regulation. As evident from electrophysiological analysis with the 2-electrode voltage-clamp technique, heterologous expression of ClC-Kb T481S in Xenopus oocytes gave rise to a current that was 7-fold larger than the current produced by wild-type ClC-Kb. The prevalence of the mutant allele was significantly higher in an African population from Ghana (22%) than in whites (12%). As tested in 1 white population, carriers of ClC-Kb T481S were associated with significantly higher systolic (by ≈6.0 mm Hg) and diastolic (by ≈4.2 mm Hg) blood pressures and significantly higher prevalence (45% versus 25%) of hypertensive (≥140/90 mm Hg) blood pressure levels. Individuals carrying ClC-Kb T481S had significantly higher plasma Na + concentrations and significantly decreased glomerular filtration rate. In conclusion, the mutation ClC-Kb T481S of the renal epithelial Cl − channel ClC-Kb strongly activates ClC-Kb chloride channel function in vitro and may predispose to the development of essential hypertension in vivo.
Immune cell infiltration of intrinsic and metastatic intracranial tumours.
2004-05-21

Malignancy or primary intracranial origin seem not to be major determinants of immune cell infiltration. Different patterns of cytokine production may explain the differences in single tumour entities.
Intracellular Multiplication of <I>Legionella</i> Species and the Influence of Amoebae on Their Intracellular Growth in Human Monocytes: Mono Mac 6 Cells and </B>Acanthamoeba castellanii as Suitable In Vitro Models
2004-05-21

Legionellae are important etiological agents of pneumonia. Legionella pneumophila (predominantly serogroup 1) is detected in most cases of legionellosis; other species only occasionally cause infections, predominantly in immunocompromized patients. Aquiferous technical systems are the primary source of infection (air-conditioning systems, refrigerators, showers, whirlpools, springs, taps, moisturizing equipment, medical nebulizers, and swimming pools). Legionellae are present in the water in these systems, within the amoebae, flagellates, and ciliates in which they replicate. After inhalation of contaminated aerosols, the bacteria multiply intracellularly within alveolar macrophages. The ability to multiply within monocytic host cells is usually considered to correspond to pathogenicity. The mechanisms of intracellular replication have been only partially characterized. Analysis of the molecular pathogenesis of Legionella infection, both in the pathogen itself and in the host cell, is the subject of current research and may lead to new options in prophylaxis and treatment. We have established the human Mono Mac 6 cell line (MM6) instead of the previously used histiocytic lymphoma cell line U 937 or the promyelocytic leukemia cell line HL-60 to investigate the intracellular replication of legionellae and the molecular pathogenesis of Legionella infection within human monocytic host cells. MM6 cells represent a more mature macrophage-like cell line that expresses phenotypic and functional properties of mature monocytes and that does not need to be stimulated by phorbol esters or 1,25-dihydroxyvitamin D3. A good correlation between the prevalence of a given Legionella species and its intracellular multiplication in MM6 cells could be demonstrated.In addition to Legionella, MM6 cells were found to support the intracellular growth of Mycobacterium tuberculosis and Chlamydia pneumoniae, two other important bacterial agents involved in induction of pneumonia. Therefore, the MM6 model might be adaptable to investigations of the molecular pathogenesis of other intracellular bacteria that can replicate within human monocytes and induce disease.
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase
2004-05-24

The class IIIa adenylyl cyclase (AC) Rv1625c from Mycobacterium tuberculosis forms homodimers with two catalytic centres, whereas the Paramecium guanylyl and mammalian ACs operate as pseudoheterodimers with one catalytic centre. The functional and structural relationship of the catalytic domains of these related class III cyclases was investigated. Point mutations introduced into Rv1625c to engineer a forskolin‐binding pocket created a single heterodimeric catalytic centre, yet did not result in forskolin activation. Chimerization of these Rv1625c point mutants with corresponding mammalian AC domains was impossible. However, it was successful using a complemental Paramecium guanylyl cyclase domain and resulted in an AC. The data signify a divergence of structural and functional evolution in class III Acs.
BCI2000: A General-Purpose Brain-Computer Interface (BCI) System
2004-05-25

Many laboratories have begun to develop brain-computer interface (BCI) systems that provide communication and control capabilities to people with severe motor disabilities. Further progress and realization of practical applications depends on systematic evaluations and comparisons of different brain signals, recording methods, processing algorithms, output formats, and operating protocols. However, the typical BCI system is designed specifically for one particular BCI method and is, therefore, not suited to the systematic studies that are essential for continued progress. In response to this problem, we have developed a documented general-purpose BCI research and development platform called BCI2000. BCI2000 can incorporate alone or in combination any brain signals, signal processing methods, output devices, and operating protocols. This report is intended to describe to investigators, biomedical engineers, and computer scientists the concepts that the BC12000 system is based upon and gives examples of successful BCI implementations using this system. To date, we have used BCI2000 to create BCI systems for a variety of brain signals, processing methods, and applications. The data show that these systems function well in online operation and that BCI2000 satisfies the stringent real-time requirements of BCI systems. By substantially reducing labor and cost, BCI2000 facilitates the implementation of different BCI systems and other psychophysiological experiments. It is available with full documentation and free of charge for research or educational purposes and is currently being used in a variety of studies by many research groups.
The BCI competition 2003: progress and perspectives in detection and discrimination of EEG single trials
2004-05-25

Interest in developing a new method of man-to-machine communication-a brain-computer interface (BCI)-has grown steadily over the past few decades. BCIs create a new communication channel between the brain and an output device by bypassing conventional motor output pathways of nerves and muscles. These systems use signals recorded from the scalp, the surface of the cortex, or from inside the brain to enable users to control a variety of applications including simple word-processing software and orthotics. BCI technology could therefore provide a new communication and control option for individuals who cannot otherwise express their wishes to the outside world. Signal processing and classification methods are essential tools in the development of improved BCI technology. We organized the BCI Competition 2003 to evaluate the current state of the art of these tools. Four laboratories well versed in EEG-based BCI research provided six data sets in a documented format. We made these data sets (i.e., labeled training sets and unlabeled test sets) and their descriptions available on the Internet. The goal in the competition was to maximize the performance measure for the test labels. Researchers worldwide tested their algorithms and competed for the best classification results. This paper describes the six data sets and the results and function of the most successful algorithms.
Support Vector Channel Selection in BCI
2004-05-25

Designing a brain computer interface (BCI) system one can choose from a variety of features that may be useful for classifying brain activity during a mental task. For the special case of classifying electroencephalogram (EEG) signals we propose the usage of the state of the art feature selection algorithms Recursive Feature Elimination and Zero-Norm Optimization which are based on the training of support vector machines (SVM). These algorithms can provide more accurate solutions than standard filter methods for feature selection. We adapt the methods for the purpose of selecting EEG channels. For a motor imagery paradigm we show that the number of used channels can be reduced significantly without increasing the classification error. The resulting best channels agree well with the expected underlying cortical activity patterns during the mental tasks. Furthermore we show how time dependent task specific information can be visualized.
Principles of a Brain-Computer Interface (BCI) Based on Real-Time Functional Magnetic Resonance Imaging (fMRI)
2004-05-25

A brain-computer interface (BCI) based on functional magnetic resonance imaging (fMRI) records noninvasively activity of the entire brain with a high spatial resolution. We present a fMRI-based BCI which performs data processing and feedback of the hemodynamic brain activity within 1.3 s. Using this technique, differential feedback and self-regulation is feasible as exemplified by the supplementary motor area (SMA) and parahippocampal place area (PPA). Technical and experimental aspects are discussed with respect to neurofeedback. The methodology now allows for studying behavioral effects and strategies of local self-regulation in healthy and diseased subjects.
BCI Competition 2003—Data Sets Ib and IIb: Feature Extraction From Event-Related Brain Potentials With the Continuous Wavelet Transform and the&lt;tex&gt;$hboxtt t$&lt;/tex&gt;-Value Scalogram
2004-05-25

The t-CWT, a novel method for feature extraction from biological signals, is introduced. It is based on the continuous wavelet transform (CWT) and Student's t-statistic. Applied to event-related brain potential (ERP) data in brain-computer interface (BCI) paradigms, the method provides fully automated detection and quantification of the ERP components that best discriminate between two samples of EEG signals and are, therefore, particularly suitable for classification of single-trial ERPs. A simple and fast CWT computation algorithm is proposed for the transformation of large data sets and single trials. The method was validated in the BCI Competition 2003, where it was a winner (provided best classification) on two data sets acquired in two different BCI paradigms, P300 speller and slow cortical potential (SCP) self-regulation. These results are presented here.
Brain-computer communication and slow cortical potentials
2004-05-25

A thought translation device (TTD) has been designed to enable direct brain-computer communication using self-regulation of slow cortical potentials (SCPs). However, accuracy of SCP control reveals high intersubject variability. To guarantee the highest possible communication speed, some important aspects of training SCPs are discussed. A baseline correction of SCPs can increase performance. Multichannel recordings show that SCPs are of highest amplitude around the vertex electrode used for feedback, but in some subjects more global distributions were observed. A new method for control of eye movement is presented. Sequential effects of trial-to-trial interaction may also cause difficulties for the user. Finally, psychophysiological factors determining SCP communication are discussed.
An EEG-Driven Brain-Computer Interface Combined With Functional Magnetic Resonance Imaging (fMRI)
2004-05-25

Self-regulation of slow cortical potentials (SCPs) has been successfully used to prevent epileptic seizures as well as to communicate with completely paralyzed patients. The thought translation device (TTD) is a brain-computer interface (BCI) that was developed for training and application of SCP self-regulation. To investigate the neurophysiological mechanisms of SCP regulation the TTD was combined with functional magnetic resonance imaging (fMRI). The technical aspects and pitfalls of combined fMRI data acquisition and EEG neurofeedback are discussed. First data of SCP feedback during fMRI are presented.
On variational approximations in quantum molecular dynamics
2004-05-25

The Dirac-Frenkel-McLachlan variational principle is the basic tool for obtaining computationally accessible approximations in quantum molecular dynamics. It determines equations of motion for an approximate time-dependent wave function on an approximation manifold of reduced dimension. This paper gives a near-optimality result for variational approximations. It bounds the error in terms of the distance of the exact wave function to the approximation manifold and identifies the parameters that control the deviation of the variational approximation from the best approximation on the manifold.
T cell avidity determines the level of CTL activation
2004-05-25

Abstract To investigate the influence of avidity on T cell activation in vitro and in vivo , we analyzed T cells from St40 and St42 mice, which express the same transgenic TCR specificfor an E1a‐derived epitope of adenovirus type 5 with different expression levels and therefore different avidities. Splenocytes from both strains showed comparable cytolytic activities and requiredidentical peptide concentrations for efficient target cell lysis and up‐regulation of activation markers. However, the kinetics of CD25 up‐regulation were strikingly different: whereas the majorityof the high‐avidity St42 T cells up‐regulated the IL‐2Rα chain within a few hours, low‐avidity St40 T cells expressed only 50% of the CD25 of high‐avidity T cells after 2 days. In addition, low‐avidity T cells proliferated poorly and displayed impaired secretion of IL‐2 and IFN‐γ. Similar results were seen with high‐avidity St42 T cells stimulated with a partial agonistic peptide. Upon adoptive transfer and subsequent immunization with adenovirus, both high‐ and low‐avidity T cells expanded, but St40 T cells were undetectable 10 days after immunization. Our model system now allowsanalysis of whether T cells with identical specificities but different avidities influence each other during activation and homeostatic proliferation.
A revenue-equivalence theorem for electricity auctions
2004-05-25

The purpose of this paper is to analyse the real-time trading of electricity. We address a model for an auction-like trading which captures key features of real-world electricity markets. Our main result establishes that, under certain conditions, the expected total payment for electricity is independent of the particular auction type. This result is analogous to the revenue-equivalence theorem known for classical auctions and could contribute to an improved understanding of different electricity market designs and their comparison.
Vector mesons in nuclear $mu;$minus;?e$minus; conversion
2004-05-25

We study nuclear μ−–e− conversion in the general framework of an effective Lagrangian approach without referring to any specific realization of the physics beyond the Standard Model (SM) responsible for lepton flavor violation (L/f). We show that vector meson exchange between lepton and nucleon currents plays an important role in this process. A new issue of this mechanism is the presence of the strange quark vector current contribution induced by the φ meson. This allows us to extract new limits on the L/f lepton–quark effective couplings from the existing experimental data.
Stable carbon isotope fractionation during aerobic and anaerobic transformation of trichlorobenzene
2004-05-25

Fractionation of stable carbon isotopes upon degradation of trichlorobenzenes was studied under aerobic and anaerobic conditions. Mineralization of 1,2,4-trichlorobenzene by the aerobic strain Pseudomonas sp. P51 which uses a dioxygenase for the initial enzymatic reaction was not accompanied by a significant isotope fractionation. In contrast, reductive dehalogenation by the anaerobic strain Dehalococcoides sp. strain CBDB1 revealed average isotope enrichment factors (η) between −3.1 and −3.7 for 1,2,3- and 1,2,4-trichlorobenzene, respectively. The significant isotope fractionation during reductive dehalogenation would allow tracing the in situ biodegradation of halogenated benzenes in contaminated anoxic aquifers, whereas the lack of isotope fractionation during aerobic transformation limits the use of this approach in oxic environments.
Intramyocellular lipids and insulin resistance
2004-05-26

Lipids are stored not only in adipocytes but also ‘ectopically’ in tissues such as muscle, liver, beta cells and others. From a metabolic perspective, intramyocellular lipids (IMCLs) have recently become a focus of interest. This review summarizes history, measurement techniques and interpretation of muscle lipid data. Problems in biopsies with the separation of those metabolically active lipid droplets in the cytoplasm of myocytes from further lipids in adipocytes are discussed as well as considerations important for analysis of correlations between IMCL content and insulin sensitivity under various circumstances. The relatively new approach to non‐invasive assessment of the IMCL content by magnetic resonance spectroscopy (MRS) is described in detail and exemplary spectra from different skeletal muscle types in humans are presented. The MRS technique allows human examinations of large cohorts for a detailed assessment of the interactions among metabolic parameters such as age, measures of adiposity, hormonal and ethnic factors and insulin resistance. IMCLs are generally positively correlated with measures of obesity and negatively with insulin sensitivity. Paradoxically, physical fitness (maximal aerobic capacity) increases both IMCL content and insulin sensitivity and therefore has to be taken into account as a confounding factor. Intervention studies with MRS further allowed to elucidate the regulation of IMCL. Molecular mechanisms and potential genetic factors on IMCL regulation are discussed as well as possible mechanisms of current treatment strategies for improving insulin sensitivity.
Neurophysiological correlates of word and pseudo‐word processing in well‐recovered aphasics and patients with right‐hemispheric stroke
2004-05-26

Abstract Neurophysiological correlates of language recovery after stroke were investigated. Neurological patients with single focal lesions in their left or right hemisphere and healthy control subjects made lexical decisions on written words and pseudo‐words while EEG responses were recorded. At the time of testing, patients did not show clinically apparent language dysfunction, although those with left‐hemisphere lesions had suffered from aphasia in the first months after their stroke. A P3‐like positive deflection of the event‐related potential (ERP) was reduced in the patients relative to healthy controls, this reduction being most pronounced over the hemisphere affected by stroke. Consistent with earlier research, healthy control subjects showed more positive ERPs to words than to pseudo‐words. This pattern was reversed in both patient groups, where words elicited more negative‐going ERPs than pseudo‐words already 160–320 ms after stimulus onset. Because ERPs showed between‐group differences only for words, these word‐specific neurophysiological signatures altered in stroke patients with well‐recovered language functions may be a correlate of cortical lesions or an index of reorganization of language after stroke.