1773 IS VEGF TARGETED THERAPY IN RENAL CELL CARCINOMA WITH LATE METASTASES TO THE PANCREAS AND THE THYROID GLAND REASONABLE? – A STUDY OF CHROMOSOMAL IMBALANCES
2011-04-01

You have accessJournal of UrologyKidney Cancer: Advanced1 Apr 20111773 IS VEGF TARGETED THERAPY IN RENAL CELL CARCINOMA WITH LATE METASTASES TO THE PANCREAS AND THE THYROID GLAND REASONABLE? – A STUDY OF CHROMOSOMAL IMBALANCES Inga-Marie Schaefer, Björn Sander, Soudah Bisharah, Arne Strauß, Philipp Schüler, Christina Enders, Laszlo Füzesi, and Jens Bedke Inga-Marie SchaeferInga-Marie Schaefer Goettingen, Germany More articles by this author , Björn SanderBjörn Sander Aarhus, Denmark More articles by this author , Soudah BisharahSoudah Bisharah Hannover, Germany More articles by this author , Arne StraußArne Strauß Goettingen, Germany More articles by this author , Philipp SchülerPhilipp Schüler Goettingen, Germany More articles by this author , Christina EndersChristina Enders Goettingen, Germany More articles by this author , Laszlo FüzesiLaszlo Füzesi Goettingen, Germany More articles by this author , and Jens BedkeJens Bedke Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2101AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Chromosomal imbalances in clear cell renal cell carcinoma (ccRCC) are common. The most relevant on chromosome 3p leads to a loss of the von Hippel-Lindau gene. In solid tumors metastases to endocrine organs rarely occur. In ccRCC they are a characteristic feature in the late onset of metastatic disease, which then are often located in the thyroid or the pancreatic gland. Aim of the study was to compare chromosomal imbalances in ccRCC metastasis of the thyroid and pancreas with the corresponding primary tumor with regard to a possible VEGF targeted therapy. METHODS A total of 63 tumor specimens with 24 metastases of the thyroid with 12 corresponding primary tumors and 19 metastasis of the pancreas with 8 corresponding primary ccRCC from 45 patients (23 men and 22 women, mean age at primary diagnosis, 57.8 years; range, 45.7 – 77.3 years, TNM 7th ed. T1 to T3b) were analysed by comparative genomic hybridization (CGH). Mean follow-up was 92.3 months, available in 33 patients (pt). RESULTS Mean time to metastasis was 87.9 in pancreas and 83.4 months in thyroid. In all tumors the most frequently observed chromosomal imbalances included losses at 3p (84.1%), 8p (31.7%) and 14q (25.4%) and gains at 5q (36.5%). Most frequent chromosomal aberrations in primary ccRCC with metastases to pancreas were losses at 3p (62.5%) and gains at 5q (50%), which increased in pancreatic metastasis to 89.5% (losses at 3p) and 52.6% (gains at 5q). Most frequent chromosomal aberrations in primary ccRCC with metastases to thyroid included losses at chromosomes 3p (83.3%), 8p (33.3%), 14q (33.3%) and 8q (25%). Thyroid metastases most frequently displayed losses at 3p (87.5%), 8p (41.7%), gains at 5q (29.2%). The comparison of the mean number of changes per tumor revealed an increase in chromosomal imbalances in pancreatic metastasis (primary tumor: 2.13 changes vs. pancreatic metastases: 4.37, p=0.071), while the number of changes in primaries of thyroid metastasis did not differ with thyroid metastasis (4.25 vs. 4.38, p=0.497). CONCLUSIONS The high frequency of 3p loss which was further increased in pancreatic metastatic tissue and in thyroid metastatic tissue when compared to the corresponding primary tumor underlines the importance of VHL / VEGF pathway alterations in ccRCC. This result supports the use of VEGF targeted therapy with a possible vulnerability of pancreas and thyroid metastasis to these agents. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e712 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Inga-Marie Schaefer Goettingen, Germany More articles by this author Björn Sander Aarhus, Denmark More articles by this author Soudah Bisharah Hannover, Germany More articles by this author Arne Strauß Goettingen, Germany More articles by this author Philipp Schüler Goettingen, Germany More articles by this author Christina Enders Goettingen, Germany More articles by this author Laszlo Füzesi Goettingen, Germany More articles by this author Jens Bedke Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...