julilili42/papers huggingface dataset:
Lei Wei (Ed.): Advanced fiber sensing technologies
2021-11-24

Optical sensors play a significant role in medicine, environmental monitoring, process control, and many other applications.They are small and immune to electromagnetic interference, and do not conduct electricity.They can be designed to withstand high temperatures.Fiber optic sensors have the additional advantage of a high level of integration, which allows even smaller sensor sizes to be realized, and the absence of light coupling issues.Due to their flexibility, they can be used under harsh conditions and in hard-to-reach places.The book introduces the complex world of multi-functional multi-material fibers.Theory, design, and application as well as future trends are discussed.Practical fiber devices with optoelectronics, photonics, acoustics, biomedicine, and energy harvesting functionalities are presented.
Effect of the Mediterranean diet on gingivitis: A randomized controlled trial
2021-11-25

Abstract Aim This study aimed to investigate the effects of a 6‐week Mediterranean diet (MD) intervention on gingival inflammatory and anthropometric parameters of patients with gingivitis. Materials and methods Forty‐two participants were allocated to MD group (MDG) or control group (CG). After a 2‐week equilibration period regarding dental care procedures, only MDG changed their diet to MD for 6 weeks, supported by a diet counselling. Gingival and anthropometric parameters were assessed at baseline ( T 0), Week 2 ( T 1, beginning of MD intervention), and Week 8 ( T 2). Adherence to MD was assessed by the Mediterranean Diet Adherence Screener (MEDAS); dietary behaviour was evaluated by the German Health Interview and Examination Survey for Adults Food Frequency Questionnaire (DEGS‐FFQ). Results Plaque values remained constant in both groups. Inflammatory periodontal and anthropometric parameters decreased in the MDG only (gingival index: T 1 1.51 ± 0.21, T 2 1.49 ± 0.24; bleeding on probing: T 1 51.00 ± 14.65, T 2 39.93 ± 13.74; body weight: T 1 79.01 ± 15.62, T 2 77.29 ± 17.00; waist circumference: T 1 84.41 ± 10.1, T 2 83.17 ± 10.47 ( p &lt; .05). MEDAS revealed a sufficient diet adherence for MDG. Conclusion Within this study, gingival inflammatory parameters were significantly reduced by MD, whereas plaque parameters remained constant. The diet counselling achieved sufficient adherence with beneficial changes in weight loss and waist circumference.
Colchicine Effectiveness and Safety in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis
2021-11-25

Introduction: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common fever syndrome in childhood. High disease activity (DA) dramatically impacts the health-related quality of life. Thus, effective and safe treatment is crucial. Colchicine might be effective, but data are still lacking. Study aimed to assess colchicine safety and effectiveness in PFAPA. Methods: This single center study was conducted between 03/2012 and 05/2021 in PFAPA patients without variants in genetic panel testing aged ≤ 18 years fulfilling Marshall criteria and classification criteria of Gattorno et al. Exclusion criteria were elevated liver enzymes, impaired kidney function, celiac disease, lactose intolerance, previous/ongoing biologics, known colchicine-intolerance. Demographics, clinical characteristics, treatment, DA, colchicine effectiveness and safety were recorded at baseline, first and last visit. Colchicine was started at 0.5–1.0 mg/day. DA was captured by physician (PGA) and patient/parent (PPGA) global assessment on a 10 cm visual analog scale, categorized as mild (&amp;lt;2), moderate (2–4), and high (≥5). Adverse event (AE) monitoring included gastrointestinal symptoms, liver enzyme/creatinine elevation, leukopenia, neutropenia. Primary outcome included response (R; composite of PPGA + PGA decrease ≥2) at last follow-up. Secondary outcomes were partial response (PR; PGA decrease = 1 + PPGA decrease ≥1), no response (NR; unchanged/worsened PGA/PPGA), colchicine safety, flare characteristics. Results: Twenty-seven PFAPA patients were included, 52% were female, median age was 5.8 years (1–10.75), median follow-up time was 13 months. At baseline, median PPGA was high; median PGA moderate. All patients had febrile flares. Median flare frequency was every 4–5 weeks; median duration 5–6 days. Nine patients were pre-treated with corticosteroids, increasing flare frequency in 8/9. Primary Outcome: 17 patients (63%) were responders. Secondary outcomes: PR was achieved in 15%; NR in 22% at last follow-up. DA decreased significantly ( p &amp;lt;0.0001). At last follow-up, 52% reported no flares, median flare duration decreased to 1–2 days. At first follow-up, 22% reported mild abdominal pain/diarrhea. Moderate abdominal pain/diarrhea occurred with ≥1 mg/day. Mild asymptomatic liver enzyme elevation or leucopenia were rare; no severe AE or colchicine discontinuation were observed. Conclusion: Colchicine seems to be safe, well-tolerated, and effective in PFAPA patients. It can be considered in children with moderate/high DA even those without corticosteroid-benefit.
Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
2021-11-25

Calcified aortic valve disease (CAVD) is the most prevalent valve disease in the elderly. Targeted pharmacological therapies are limited since the underlying mechanisms of CAVD are not well understood. Appropriate 3D in vitro models could potentially improve our knowledge of the disease. Here, we developed a 3D in vitro aortic heart valve model that resembles the morphology of the valvular extracellular matrix and mimics the mechanical and physiological behavior of the native aortic valve fibrosa and spongiosa. We employed cryogenic electrospinning to engineer a bi-layered cryogenic electrospun scaffold (BCES) with defined morphologies that allowed valvular endothelial cell (VEC) adherence and valvular interstitial cell (VIC) ingrowth into the scaffold. Using a self-designed cell culture insert allowed us to establish the valvular co-culture simultaneously by seeding VICs on one side and VECs on the other side of the electrospun scaffold. Proof-of-principle calcification studies were successfully performed using an established osteogenic culture protocol and the here designed 3D in vitro aortic heart valve model. STATEMENT OF SIGNIFICANCE: Three-dimensional (3D) electrospun scaffolds are widely used for soft tissue engineering since they mimic the morphology of the native extracellular matrix. Several studies have shown that cells behave more naturally on 3D materials than on the commonly used stiff two-dimensional (2D) cell culture substrates, which have no biological properties. As appropriate 3D models for the study of aortic valve diseases are limited, we developed a novel bi-layered 3D in vitro test system by using the versatile technique of cryogenic electrospinning in combination with the influence of different solvents to mimic the morphology, mechanical, and cellular distribution of a native aortic heart valve leaflet. This 3D in vitro model can be used to study valve biology and heart valve-impacting diseases such as calcification to elucidate therapeutic targets.
Changing gender role behaviors of south Asian men in different gender regimes: A comparative study of COVID‐19 lockdown in Pakistan and Germany
2021-11-25

This comparative study of COVID‐19 lockdown aims to underline changes in gender role behaviors of South‐Asian men (husbands) living in different gender regimes: Pakistan and Germany. As a nascent contribution to existing discourses of political science (gender regimes), international migration, and men and masculinity, the study compares self‐reported changes in husbands' masculine and feminine role behaviors with perceptions of their wives during the lockdown period. A gender role behavior scale is adapted to design an online survey and collect data through convenient and snowball sampling techniques. By computing analysis of variance (ANOVA) with repeated measures, the study infers that the COVID‐19 driven first lockdown has limited the mobility of men (husbands). Thus, they have reported a significant decline in their traditional masculine role behaviors (outside the home) in both countries. Nonetheless, a subsequent increase does not appear in their feminine role behaviors. Although temporary suspension of their breadwinning roles due to lockdown has allowed them to modify their gender role behaviors by sharing increased domestic and caregiving tasks in families, a significant change does not appear in their behaviors. Findings conclude that social upheaval (COVID‐19) does not convince men (husbands) to interchange their masculine and feminine role behaviors in families. Thus, inferences support key prims of bio‐socialists that gender role behaviors are inherited and may change through cultural advancements (through gender education and enabling legal frameworks) in relatively less gender‐egalitarian societies and proper ‘gendered integration’ initiatives in relatively more gender‐egalitarian societies.
Couples’ Communication Behaviour and the Gender Division of Family Work Across the Transition to Parenthood
2021-11-25

This study investigates the conceptual argument that constructive and explicit couple communication may reduce gender inequalities in couples’ division of family work. We focus on the transition to parenthood which for most couples in Germany results in a shift towards a more traditional division of labour. Using 314 first-time parents from the German Family Panel, we apply growth curve models to assess whether partners’ prenatal characteristics explain the division of housework and childcare around the time of childbirth and in the following years. After controlling for gender ideologies and economic resources, male partners’ frequency of positive communication is associated with greater father involvement in housework and childcare from the start. However, neither men’s nor women’s communication behaviours dampen the shift towards a more traditional division of housework and childcare in the first years after childbirth. The frequency of negative communication does not correlate with the division of family work.
Experimentation preceding innovation in a MIS5 Pre-Still Bay layer from Diepkloof Rock Shelter (South Africa): emerging technologies and symbols
2021-11-25

In southern Africa, key technologies and symbolic behaviors develop as early as the later Middle Stone Age in MIS5. These innovations arise independently in various places, contexts and forms, until their full expression during the Still Bay and the Howiesons Poort. The Middle Stone Age sequence from Diepkloof Rock Shelter, on the West Coast of the region, preserves archaeological proxies that help unravelling the cultural processes at work. This unit yields one of the oldest abstract engraving so far discovered in Africa, in the form of a rhomboid marking on the cortical surface of an ungulate long bone shaft. The comprehensive analysis of the lithic artefacts and ochre pieces found in association with the engraved bone documents the transport of rocks over long distance (&gt;20km), the heat treatment of silcrete, the coexistence of seven lithic reduction strategies (including the production of bladelets and the manufacture of unifacial and bifacial points), the use of adhesives and the processing of ochre. At Diepkloof, the appearance of engraving practices take place in a context that demonstrates a shift in rock procurement and a diversification in lithic reduction strategies, suggesting that these behavioral practices acted as a cultural answer to cope with new environmental and/or socio-economic circumstances. We argue that the innovations later found during the Still Bay and the Howiesons Poort were already in the making during the MIS5 pre-Still Bay, though not all the benefits were yet taken advantage of by the populations.
Die Bedeutung Hans Vaihingers für die Kant-Forschung seiner Zeit – ein chronologischer Überblick
2021-11-25

Abstract This paper scrutinizes and chronologically reconstructs Hans Vaihinger’s impact on contemporary Kant research. It provides an account of his engagement at both the exegetical and the institutional level. More broadly, it allows us to appreciate – for the first time, and in a comprehensive way – Vaihinger’s significance to the assessment of Kant’s legacy.
The societal impact of electronic sport: a scoping review
2021-11-26

Abstract Competitive computer gaming, known as electronic sport or esport, is growing and professionalizing profoundly during the past years with experts struggling to allocate it in society. This scoping review explores existing evidence and identifies potential societal impact of esport by applying the Mapping Elite Sports Societal Impact Model. Main findings included insights on the motivation of passive and active esport consumption, beneficial socializing, pedagogical or educational aspects, hegemonial clinical pictures in esport, differing popularity regarding demographics and games, and potential interference of the esport economy in traditional sports. The findings implicate a paradigm shift in the world of sport. It can be stated that esport affects society in a positive and a negative way, although the fragmented body of research has only given superficial evidence so far. Future research needs to go into detail regarding the peculiarities and find approaches of isolating the positive aspects, while reducing the negative spin-offs and allow a well-regulated handling of esport on a broad societal level.
Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology
2021-11-26

Non-invasive physical plasma (NIPP) is a novel therapeutic tool, currently being evaluated for the treatment of cancer and precancerous lesions in gynecology and other disciplines. Additionally, patients with cervical intraepithelial neoplasia (CIN) may benefit from NIPP treatment due to its non-invasive, side-effect-free, and tissue-sparing character. However, the molecular impact of in vivo NIPP treatment needs to be further investigated. For this purpose, usually only very small tissue biopsies are available after NIPP treatment. Here, we adapted DigiWest technology, a high-throughput bead-based Western blot, for the analysis of formalin-fixed paraffin-embedded (FFPE) cervical punch biopsies with a minimal sample amount. We investigated the molecular effects of NIPP treatment directly after (0 h) and 24 h after in vivo application. Results were compared to in vitro NIPP-treated human malignant cervical cells. NIPP effects were primarily based on an inhibitory impact on the cell cycle and cell growth factors. DigiWest technology was suitable for detailed protein profiling of small, primary FFPE biopsies.
Evaluation of whole-genome sequence data analysis approaches for short- and long-read sequencing of Mycobacterium tuberculosis
2021-11-26

Whole-genome sequencing (WGS) of Mycobacterium tuberculosis (MTB) isolates can be used to get an accurate diagnosis, to guide clinical decision making, to control tuberculosis (TB) and for outbreak investigations. We evaluated the performance of long-read (LR) and/or short-read (SR) sequencing for anti-TB drug-resistance prediction using the TBProfiler and Mykrobe tools, the fraction of genome recovery, assembly accuracies and the robustness of two typing approaches based on core-genome SNP (cgSNP) typing and core-genome multi-locus sequence typing (cgMLST). Most of the discrepancies between phenotypic drug-susceptibility testing (DST) and drug-resistance prediction were observed for the first-line drugs rifampicin, isoniazid, pyrazinamide and ethambutol, mainly with LR sequence data. Resistance prediction to second-line drugs made by both TBProfiler and Mykrobe tools with SR- and LR-sequence data were in complete agreement with phenotypic DST except for one isolate. The SR assemblies were more accurate than the LR assemblies, having significantly ( P &lt;0.05) fewer indels and mismatches per 100 kbp. However, the hybrid and LR assemblies had slightly higher genome fractions. For LR assemblies, Canu followed by Racon, and Medaka polishing was the most accurate approach. The cgSNP approach, based on either reads or assemblies, was more robust than the cgMLST approach, especially for LR sequence data. In conclusion, anti-TB drug-resistance prediction, particularly with only LR sequence data, remains challenging, especially for first-line drugs. In addition, SR assemblies appear more accurate than LR ones, and reproducible phylogeny can be achieved using cgSNP approaches.
Mental State Detection Using Riemannian Geometry on Electroencephalogram Brain Signals
2021-11-26

The goal of this study was to implement a Riemannian geometry (RG)-based algorithm to detect high mental workload (MWL) and mental fatigue (MF) using task-induced electroencephalogram (EEG) signals. In order to elicit high MWL and MF, the participants performed a cognitively demanding task in the form of the letter n -back task. We analyzed the time-varying characteristics of the EEG band power (BP) features in the theta and alpha frequency band at different task conditions and cortical areas by employing a RG-based framework. MWL and MF were considered as too high, when the Riemannian distances of the task-run EEG reached or surpassed the threshold of the baseline EEG. The results of this study showed a BP increase in the theta and alpha frequency bands with increasing experiment duration, indicating elevated MWL and MF that impedes/hinders the task performance of the participants. High MWL and MF was detected in 8 out of 20 participants. The Riemannian distances also showed a steady increase toward the threshold with increasing experiment duration, with the most detections occurring toward the end of the experiment. To support our findings, subjective ratings (questionnaires concerning fatigue and workload levels) and behavioral measures (performance accuracies and response times) were also considered.
Potentials and perspectives of food self-sufficiency in urban areas—a case study from Leipzig
2021-11-26

Abstract Regionalization of food systems is a potential strategy to support environmental, economic and social sustainability. However, local preconditions need to be considered to assess the feasibility of such a transformation process. To better understand the potentials and perspectives of food self-sufficiency in urban and peri-urban areas, we determined the food self-sufficiency level (SSL) of a German metropolitan region, i.e., the percentage of the food demand that could be potentially provided on existing agricultural land. Main input parameters were actual food demand, agricultural productivity and its temporal variability and land availability. Furthermore, we considered changes in diet, food losses and land management. Based on current diets and agricultural productivity, the administrative region of Leipzig achieved a mean SSL of 94%, ranging from 77 to 116%. Additionally, an area of 26,932 ha, representing 12% of the regionally available agricultural land, was needed for commodities that are not cultivated regionally. Changes in food demand due to a diet shift to a more plant-based diet and reduced food losses would increase the SSL by 29 and 17%, respectively. A shift to organic agriculture would decrease the SSL by 34% due to lower crop yields compared with conventional production. However, a combination of organic agriculture with less food loss and a more plant-based diet would lead to a mean SSL of 95% (75–115%). Our results indicate the feasibility of food system regionalization in the study area under current and potential near future conditions. Addressing a combination of multiple dimensions, for example plant-based and healthier diets combined with reduced food loss and organic farming, is the most favorable approach to increase food self-sufficiency in urban and peri-urban areas and simultaneously provide synergies with social and environmental objectives.
Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation
2021-11-26

Abstract To fulfil their orchestrating function in immune cell trafficking in homeostasis and disease, a network of 49 chemokines and 23 receptors capitalizes on features of specificity, redundancy, and functional selectivity such as biased agonism. The discovery of the chemokine interactome, i.e. heteromeric chemokine-chemokine interactions, even across CC- and CXC-class borders, has further expanded the complexity within the network. Moreover, some inflammatory mediators, which are not structurally linked to classical CC-, CXC-, CX 3 C-, or C-chemokines, can bind to chemokine receptors and behave as atypical chemokines (ACKs). We identified the cytokine macrophage migration inhibitory factor (MIF) as an ACK that binds to the chemokine receptors CXCR2 and CXCR4 to promote atherogenic leukocyte recruitment. Here, we hypothesized that chemokine-chemokine interactions extend to ACKs and that MIF may form heterocomplexes with classical chemokines. We tested this hypothesis, applying an unbiased chemokine protein binding array. The platelet chemokine CXCL4L1, but not its variant CXCL4 or the CXCR2/CXCR4 ligands CXCL8 or CXCL12, was identified as a candidate interactor. MIF/CXCL4L1 complexation was verified by co-immunoprecipitation, surface plasmon-resonance analysis, and microscale thermophoresis, which also established high-affinity binding (K D ≍100-150 nM). The binding interface was predicted by peptide array-based mapping and molecular docking. We next determined whether heterocomplex formation modulates inflammatory and atherogenic activities of MIF. MIF-elicited T-cell chemotaxis as assessed in a 3D-matrix-based live cell-imaging set-up was abrogated, when cells were co-incubated with MIF and CXCL4L1. Heterocomplexation also blocked MIF-triggered migration of Egfp + microglia in cortical cultures in situ . Of note, CXCL4L1 blocked the binding of Alexa-MIF to a soluble ectodomain mimic of CXCR4 and co-incubation with CXCL4L1 attenuated MIF-triggered dynamic mass redistribution in HEK293-CXCR4 transfectants, indicating that complex formation interferes with MIF/CXCR4 pathways. As MIF and CXCL4L1 are abundant platelet products, we finally tested their role in platelet activation. Multi-photon microscopy, FLIM- FRET, and proximity ligation assay visualized heterocomplexes in platelet aggregates and clinical human thrombus sections. Moreover, heterocomplex formation inhibited MIF- stimulated thrombus formation under flow and skewed the morphology of adhering platelets from a large to a small lamellipodia phenotype. Together, our study establishes a novel molecular interaction, adding to the complexity of the chemokine interactome and chemokine/receptor network. MIF/CXCL4L1, or more generally, ACK/CXC-motif chemokine heterocomplexes may be promising target structures to modulate inflammation and thrombosis.