132 XPA-210 - A NEW PROLIFERATION MARKER DETERMINES LOCALLY ADVANCED PROSTATE CANCER AND IS A PREDICTOR OF BIOCHEMICAL RECURRENCE
2011-04-01

You have accessJournal of UrologyProstate Cancer: Basic Research1 Apr 2011132 XPA-210 - A NEW PROLIFERATION MARKER DETERMINES LOCALLY ADVANCED PROSTATE CANCER AND IS A PREDICTOR OF BIOCHEMICAL RECURRENCE Stefan Aufderklamm, Joerg Hennenlotter, David Schilling, Tilman Todenhoefer, Saladin Alloussi, Georgios Gakis, Ulrich Vogel, Ursula Kuehs, Valentina Gerber, Joachim Hevler, Arnulf Stenzl, and Christian Schwentner Stefan AufderklammStefan Aufderklamm Tuebingen, Germany More articles by this author , Joerg HennenlotterJoerg Hennenlotter T. Germany More articles by this author , David SchillingDavid Schilling T. Germany More articles by this author , Tilman TodenhoeferTilman Todenhoefer T. Germany More articles by this author , Saladin AlloussiSaladin Alloussi Tuebingen, Germany More articles by this author , Georgios GakisGeorgios Gakis Tuebingen, Germany More articles by this author , Ulrich VogelUlrich Vogel Tuebingen, Germany More articles by this author , Ursula KuehsUrsula Kuehs Tuebingen, Germany More articles by this author , Valentina GerberValentina Gerber Tuebingen, Germany More articles by this author , Joachim HevlerJoachim Hevler San Diego, CA More articles by this author , Arnulf StenzlArnulf Stenzl Tuebingen, Germany More articles by this author , and Christian SchwentnerChristian Schwentner Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.199AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES XPA-210 is a peptide proliferation marker derived from thymidine kinase 1 (TK1). TK1 has been reported to be of clinical significance in several cancer entities (e.g. breast, lung and bladder cancer). However, nothing is yet known about the significance of XPA-210 in prostate cancer (PC). Aim of the present study was to determine the applicability of XPA-210 for diagnostic and prognostic purposes in PC. METHODS Paraffin embedded tumor and corresponding benign tissue from 111 patients (Median age 65 years, Median PSA value 8.9, Median Gleason score 6, 75xT2 and 36xT>2, 5xN1) who underwent radical prostatectomy between January 2003 and February 2004 were constructed to a tissue microarray (TMA) and stained immunohistochemically for XPA-210. Staining was quantitatively given as a percentage of positive cells per 100 cells. Results were correlated to pathological and clinical patient data using the Wilcoxon-Kruskall-Wallis tests and linear regression analyses. Expressions in tumor tissues were correlated to the time of biochemical recurrence by the Kaplan-Meier method. RESULTS Mean staining score was 0.51 (Median 0.3) and 0.14 (0.08) for tumor and benign tissue, respectively (p<0.0001). Tumor staining score was significantly associated with PSA values (p<0.05), Gleason score <6/≥6 (p<0.0001) and organ-confinement (T2/T>3) (p=0.002). When looking at the time to recurrence, increasing XPA-210 expression scores were significantly correlated with a shorter time to biochemical relapse (p=0.003). CONCLUSIONS XPA-210 allows for the differentiation of cancerous and normal prostatic tissue in diagnostic terms. Moreover, associations with classical parameters of PC progression point out a prognostic significance, especially in predicting biochemical recurrence. These data confirm the applicability of XPA-210 in PC-patients in terms of tissue-based diagnosis and as a progression marker. Hence, XPA-210 may be an additional tool to facilitate appropriate patient selection for local therapy or active surveillance. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e56 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stefan Aufderklamm Tuebingen, Germany More articles by this author Joerg Hennenlotter T. Germany More articles by this author David Schilling T. Germany More articles by this author Tilman Todenhoefer T. Germany More articles by this author Saladin Alloussi Tuebingen, Germany More articles by this author Georgios Gakis Tuebingen, Germany More articles by this author Ulrich Vogel Tuebingen, Germany More articles by this author Ursula Kuehs Tuebingen, Germany More articles by this author Valentina Gerber Tuebingen, Germany More articles by this author Joachim Hevler San Diego, CA More articles by this author Arnulf Stenzl Tuebingen, Germany More articles by this author Christian Schwentner Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...