2057 EVIDENCE FOR AN AGE DEPENDENCE OF THE PROSTATE CANCER ANTIGEN 3 (PCA3) SCORE
2010-03-23

You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 20102057 EVIDENCE FOR AN AGE DEPENDENCE OF THE PROSTATE CANCER ANTIGEN 3 (PCA3) SCORE David Schilling, Joerg Hennenlotter, Julian Siegel, Veronika Wagner, Christian Schwentner, and Arnulf Stenzl David SchillingDavid Schilling More articles by this author , Joerg HennenlotterJoerg Hennenlotter More articles by this author , Julian SiegelJulian Siegel More articles by this author , Veronika WagnerVeronika Wagner More articles by this author , Christian SchwentnerChristian Schwentner More articles by this author , and Arnulf StenzlArnulf Stenzl More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2104AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate caner antigen 3 (PCA3) recently has been introduced into clinical routine as a prostate cancer (PC) urine marker. However, unlike in serum prostate specific antigen (PSA) little is known about age related changes in the test score. Aim of the study was to evaluate a possible age relation of the PCA3 score. METHODS Age, PCA3 score and prostate volume from 386 consecutive patients with available histological results were documented. Age and prostate volume was correlated to the PCA3 score for the whole cohort and for the subgroups without PC and with PC by linear regression analysis. In a multivariate analysis age, histology and prostate volume was correlated to PCA3 as response. RESULTS PCA3 was positively associated with patients' age in the whole group (p<0.0001) as well as in the subgroup without (p=0.0004) and with (p=0.0001) PC, respectively. PCA3 was not associated with prostate volume in none of the groups. In multivariate analysis age revealed strongest impact on the PCA3 score (p<0.0001) followed by histology (p=0.0086) whereas prostate volume showed no impact on PCA3 at all. CONCLUSIONS In this cohort PCA3 showed significant age dependence. Beside more closely examinations of stages and grades in the investigated PC group and considerations about limitations of biopsy accuracy further attention should be turned to this potential impact factor. Especially the results form patients without PC implicate an age related base line value of PCA3 and one might consider the need for age related cut off values in order to further enhance the diagnostic accuracy of PCA3. Tuebingen, Germany© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e799-e800 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information David Schilling More articles by this author Joerg Hennenlotter More articles by this author Julian Siegel More articles by this author Veronika Wagner More articles by this author Christian Schwentner More articles by this author Arnulf Stenzl More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...