julilili42/papers huggingface dataset:
Multi‐target attention and visual short‐term memory capacity are closely linked in the intraparietal sulcus
2019-05-06

Abstract The existing literature suggests a critical role for both the right intraparietal sulcus (IPS) and the right temporo‐parietal junction (TPJ) in our ability to attend to multiple simultaneously‐presented lateralized targets (multi‐target attention), and the failure of this ability in extinction patients. Currently, however, the precise role of each of these areas in multi‐target attention is unclear. In this study, we combined the theory of visual attention (TVA) with functional magnetic resonance imaging (fMRI) guided continuous theta burst stimulation (cTBS) in neurologically healthy subjects to directly investigate the role of the right IPS and TPJ in multi‐target attention. Our results show that cTBS at an area of the right IPS associated with multi‐target attention elicits a reduction of visual short‐term memory capacity. This suggests that the right IPS is associated with a general capacity‐limited encoding mechanism that is engaged regardless of whether targets have to be attended or remembered. Curiously, however, cTBS to the right IPS failed to elicit extinction‐like behavior in our study, supporting previous suggestions that different areas of the right IPS may provide different contributions to multi‐target attention. CTBS to the right TPJ failed to induce a change in either TVA parameters or extinction‐like behavior.
Modeling morphological priming in German with naive discriminative learning
2019-05-06

Both localist and connectionist models, based on experimental results obtained for English and French, assume that the degree of semantic compositionality of a morphologically complex word is reflected in how it is processed. Since priming experiments using English and French morphologically related prime-target pairs reveal stronger priming when complex words are semantically transparent (e.g., refill–fill ) compared to semantically more opaque pairs (e.g., restrain–strain), localist models set up connections between complex words and their stems only for semantically transparent pairs. Connectionist models have argued that the effect of transparency should arise as an epiphenomenon in PDP networks. However, for German, a series of studies has revealed equivalent priming for both transparent and opaque prime-target pairs, which suggests mediation of lexical access by the stem, independent of degrees of semantic compositionality. This study reports a priming experiment that replicates equivalent priming for transparent and opaque pairs. We show that these behavioral results can be straightforwardly modeled by a computational implementation of Word and Paradigm Morphology (WPM), Naive Discriminative Learning (NDL). Just as wpm, ndl eschews the theoretical construct of the morpheme. Ndl succeeds in modeling the German priming data by inspecting the extent to which a discrimination network pre-activates the target lexome from the orthographic properties of the prime. Measures derived from an ndl network, complemented with a semantic similarity measure derived from distributional semantics, predict lexical decision latencies with somewhat improved precision compared to classical measures such as word frequency, prime type, and human association ratings. We discuss both the methodological implications of our results, as well as their implications for models of the mental lexicon.
Response to the Letter to the Editor From Marcotte (2019) Regarding “The History of Stuttering by 7 Years: Follow-Up of a Prospective Community Cohort” by Kefalianos et al. (2017)
2019-05-06

Purpose The purpose of this letter is to respond to Marcotte's (2019) letter to the editor, “The Influence of Treatment on Children's Recovery from Stuttering: Comments on Kefalianos et al. (2017) and Leech et al. (2017),” published by the Journal of Speech, Language, and Hearing Research .
Front Cover: Structure–Activity and Structure–Toxicity Relationships of Peptoid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Antiplasmodial Activity (ChemMedChem 9/2019)
2019-05-06

The Front Cover illustrates hit compound 2h which is active on Plasmodium falciparum-infected erythrocytes. A homology model of the putative P. falciparum histone deacetylase (HDAC) molecular target is shown in gold. The neglected disease malaria is responsible for over 400,000 deaths each year, and P. falciparum is the most lethal of the human malaria parasites. Parasite resistance has been reported for all currently used antimalarial drugs, and new drugs are needed. In this work we present peptoid-based HDAC inhibitors as novel compounds with potent dual-stage antiplasmodial activity. Cover artwork by M. K. W. Mackwitz and E. Hesping. More information can be found in the Full Paper by Finn K. Hansen, Katherine T. Andrews et al. on page 912 in Issue 9, 2019 (DOI: 10.1002/cmdc.201800808).
Polyacenes and diffuse interstellar bands
2019-05-07

\\nThe identification of the carriers of the diffuse interstellar bands (DIBs) remains to be established, with the exception of five bands attributed to C , although it is generally agreed that DIB carriers should be large carbon-based molecules (with ~10–100 atoms) in the gas phase, such as polycyclic aromatic hydrocarbons (PAHs), long carbon chains or fullerenes. The aim of this paper is to investigate more specific possible carriers among PAHs, namely elongated molecules, which could explain a correlation between the DIB wavelength and the apparent UV resilience of their carriers. More specifically, we address the case of polyacenes, C4N+2H2N+4, with N ~ 10–18 fused rectilinear aligned hexagons. Polyacenes are attractive DIB carrier candidates because their high symmetry and large linear size allow them to form regular series of bands in the visible range with strengths larger than most other PAHs, as confirmed by recent laboratory results up to undecacene (C46H26). Those with very strong bands in the DIB spectral domain are just at the limit of stability against UV photodissociation. They are part of the prominent PAH family of interstellar carbon compounds, meaning that only ~10−5 of the total PAH abundance is enough to account for a medium-strength DIB. After summarizing the limited current knowledge about the complex properties of polyacenes and recent laboratory results, the likelihood that they might meet the criteria for being carriers of some DIBs is addressed by reviewing the following properties: wavelength and strength of their series of visible bands; interstellar stability and abundances, charge state and hydrogenation; and DIB rotation profiles. No definite inconsistency has been identified that precludes polyacenes from being the carriers of some DIBs with medium or weak strength, including the so-called C2 DIBs. But, despite their many interesting properties, additional experimental data about long acenes and their visible bands are needed to make robust conclusions. \\n
ChandraX-ray spectroscopy of the focused wind in the Cygnus X-1 system
2019-05-07

We present an analysis of three Chandra High Energy Transmission Gratings observations of the black hole binary Cyg X-1/HDE 226868 at different orbital phases. The stellar wind that is powering the accretion in this system is characterized by temperature and density inhomogeneities including structures, or “clumps”, of colder, more dense material embedded in the photoionized gas. As these clumps pass our line of sight, absorption dips appear in the light curve. We characterize the properties of the clumps through spectral changes during various dip stages. Comparing the silicon and sulfur absorption line regions (1.6–2.7 keV ≡ 7.7–4.6 Å) in four levels of varying column depth reveals the presence of lower ionization stages, i.e., colder or denser material, in the deeper dip phases. The Doppler velocities of the lines are roughly consistent within each observation, varying with the respective orbital phase. This is consistent with the picture of a structure that consists of differently ionized material, in which shells of material facing the black hole shield the inner and back shells from the ionizing radiation. The variation of the Doppler velocities compared to a toy model of the stellar wind, however, does not allow us to pin down an exact location of the clump region in the system. This result, as well as the asymmetric shape of the observed lines, point at a picture of a complex wind structure.
Axial quasinormal modes of scalarized neutron stars with massive self-interacting scalar field
2019-05-07

We study the axial quasi-normal modes of neutron stars in scalar-tensor theories with massive scalar field including a self-interacting term in the potential. Various realistic equations of state including nuclear, hyperonic and hybrid matter are employed. Although the effect of spontaneous scalarization of neutron stars can be very large, binary pulsar observations and gravitational wave detections significantly constrain the massless scalar-tensor theories. If we consider a properly chosen nonzero mass for the scalar field, though, the scalar-tensor parameters cannot be restricted by the observations, resulting in large deviation from pure general relativity. With this motivation in mind, we extend the universal relations for axial quasi-normal modes known in general relativity to neutron stars in massive scalar-tensor theories with self-interaction using a wide range of realistic EOS. We confirm the universality of the scaled frequency and damping time in terms of the compactness and scaled moment of inertia for neutron stars with and without massive scalarization.
Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review
2019-05-07

Bone health in prostate cancer patients represents a prerequisite for acceptable quality of life and optimal outcome of this disease. The major threat for bone health in prostate cancer displays cancer treatment induced bone loss as well as the development of bone metastases. In recent years, several new pharmaceuticals targeting bone metabolism such as denosumab or androgen pathway targeting drugs (abiraterone acetate and enzalutamide) have been approved for the treatment of progressive disease aiming to interrupt the vicious circle of bone metastasis and aberrant bone resorption. This development raised the awareness of the pivotal role of bone health in prostate cancer and introduced (symptomatic) skeletal related events as an important end point in recent clinical trials. Bone targeted drugs have become standard of care in patients with metastatic castration resistant prostate cancer, their role in metastatic hormone sensitive prostate cancer has been discussed controversely. In oligometastatic prostate cancer patients several promising approaches in metastasis directed therapy, including conventional surgery, stereotactic ablative radiation and image-guided single-fraction robotic stereotactic radiosurgery (CyberKnife®) were launched but are not in routine clinical use until now caused by sparse clinical evidence.
Genetic Testing in the Diagnosis and Biology of Myeloid Neoplasms (Excluding Acute Leukemias)
2019-05-07

Abstract Objectives The 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology reviewed the role of genetic testing in the diagnosis of hematopoietic neoplasms, including non–acute leukemia myeloid malignancies. Methods The workshop panel assigned 98 submitted cases to the category of non–acute leukemia myeloid neoplasms, of which 13 were selected for oral presentation. Results Data from both conventional karyotyping and genetic sequencing had important impact on diagnosis, classification, and prognostication. However, some cases had genetic results that appeared discordant from the morphology and/or clinical features. Thus, the workshop underscored the need for careful management of genetic data by the pathologist and clinician, in the context of other findings. Conclusions The workshop cases highlighted the significance of genetic aberrations in the diagnosis and treatment of non–acute leukemia myeloid neoplasms. Many genetic data have already been incorporated in the most recent World Health Organization classification, and undoubtedly they will factor increasingly in future classifications.
Cell Death Triggered by the YUCCA-like Bs3 Protein Coincides with Accumulation of Salicylic Acid and Pipecolic Acid But Not of Indole-3-Acetic Acid
2019-05-08

The pepper (<i>Capsicum annuum</i>) resistance gene <i>bacterial spot3</i> (<i>Bs3</i>) is transcriptionally activated by the matching <i>Xanthomonas euvesicatoria</i> transcription-activator-like effector (TALE) AvrBs3. AvrBs3-induced <i>Bs3</i> expression triggers a rapid and local cell death reaction, the hypersensitive response (HR). Bs3 is most closely related to plant flavin monooxygenases of the YUCCA (YUC) family, which catalyze the final step in auxin biosynthesis. Targeted mutagenesis of predicted NADPH- and FAD-cofactor sites resulted in Bs3 derivatives that no longer trigger HR, thereby suggesting that the enzymatic activity of Bs3 is crucial to Bs3-triggered HR. Domain swap experiments between pepper <i>Bs3</i> and Arabidopsis (<i>Arabidopsis thaliana</i>) <i>YUC8</i> uncovered functionally exchangeable and functionally distinct regions in both proteins, which is in agreement with a model whereby <i>Bs3</i> evolved from an ancestral <i>YUC</i> gene. Mass spectrometric measurements revealed that expression of <i>YUC</i>s, but not expression of <i>Bs3</i>, coincides with an increase in auxin levels, suggesting that Bs3 and YUCs, despite their sequence similarity, catalyze distinct enzymatic reactions. Finally, we found that expression of <i>Bs3</i> coincides with increased levels of the salicylic acid and pipecolic acid, two compounds that are involved in systemic acquired resistance.
Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei
2019-05-08

The effects of the common nonsense TLR5:c.1174C>T polymorphism on the host inflammatory response to B. pseudomallei may not be restricted to flagellin-driven pathways. Moreover, TLR5 may modulate TLR4-dependent cytokine production. While these results may have broader implications for the role of TLR5 in the innate immune response in melioidosis and other conditions, further studies of the mechanisms underlying these observations are required.
Self and Body Part Localization in Virtual Reality: Comparing a Headset and a Large-Screen Immersive Display
2019-05-08

It is currently not fully understood where people precisely locate themselves in their bodies, particularly in virtual reality. To investigate this, we asked participants to point directly at themselves and to several of their body parts with a virtual pointer, in two virtual reality (VR) setups, a VR headset and a large-screen immersive display (LSID). There was a difference in distance error in pointing to body parts depending on VR setup. Participants pointed relatively accurately to many of their body parts (i.e., eyes, nose, chin, shoulders, and waist). However, in both VR setups when pointing to the feet and the knees they pointed too low, and for the top of the head too high (to larger extents in the VR headset). Taking these distortions into account, the locations found for pointing to self were considered in terms of perceived bodies, based on where the participants had pointed to their body parts in the two VR setups. Pointing to self in terms of the perceived body was mostly to the face, the upper followed by the lower, as well as some to the torso regions. There was no significant overall effect of VR condition for pointing to self in terms of the perceived body (but there was a significant effect of VR if only the physical body (as measured) was considered). In a paper-and-pencil task outside of VR, performed by pointing on a picture of a simple body outline (body template task), participants pointed most to the upper torso. Possible explanations for the differences between pointing to self in the VR setups and the body template task are discussed. The main finding of this study is that the VR setup influences where people point to their body parts, but not to themselves, when perceived and not physical body parts are considered.
Hormones Matter? Association of the Menstrual Cycle With Selective Attention for Liked and Disliked Body Parts
2019-05-08

Body dissatisfaction is wide spread among women and is considered a risk factor for eating pathology. Therefore, it is clinically relevant to investigate potential influencing factors. While previous research has mainly revealed inconsistent findings for attentional processes in body perception, the present study aimed to investigate the association of menstrual cycle phase with body satisfaction and its perception. In a within subject design, 16 women with a natural menstrual cycle (NC) and 19 women who used hormonal contraception (HC) rated their bodily attractiveness and underwent a 3-minute mirror exposure while their eye movements were recorded at two different times during their cycle (NC: ovulation vs. late luteal phase; HC: mid vs. end of cycle). At ovulation, NC women felt more attractive and gazed less at unattractive body parts in contrast to the late luteal phase, where they felt less attractive and gazed more at unattractive body parts. There was no difference in the gaze pattern for the attractive body parts at ovulation and late luteal phase. Notably, HC women showed a balanced gazed pattern at attractive and unattractive body at both times. The menstrual cycle phase is associated with women's self-rated attractiveness and selective attention when looking at their own body. It should therefore be taken into account in clinical research addressing body image.
Possible species-flock scenario for the evolution of the cyprinid genus Capoeta (Cypriniformes: Cyprinidae) within late Neogene lake systems of the Armenian Highland
2019-05-08

We studied 4 Ma old isolated pharyngeal teeth from lake sediments of Çevirme (Tekman Palaeolake, Erzurum Province). Based on shape characters defined for 3D models of modern species, we found that the Pliocene lake constitutes sympatric occurrence of four Capoeta species (C. cf. umbla, C. cf. baliki, C. cf. sieboldi and C. sp. sevangi/capoeta), whose modern relatives belong to a monophyletic clade inhabiting today three different drainage systems of this region (Euphrates River, Kura River and Black Sea). We interpreted this high local diversity of closely related species in terms of the species-flock model. The Tekman palaeolake was a part of an unrecognized extended late Miocene to Pliocene palaeolake system in the present-day Armenian Highland, which has been disrupted by Pliocene tectonic activities. Surface uplift of the Armenian Highland contributed to the very characteristic biogeographic distribution and endemism of Capoeta in West Asian drainage systems. Thus, we proposed a species-flock scenario for the evolution and dispersal of the cyprinid genus Capoeta in a huge unrecognized palaeolake system in the present-day Armenian Highland.
Fall if it Lifts your Teammate: A Novel Type of Candidate Manipulation
2019-05-08

We present a new interpretation of the traditional computational social choice framework, where what are traditionally the candidates are construed as the agents. The particular implementation in mind is the proposed system for determining the medal winners for sports climbing in the 2020 Olympic games. We consider the issues of ties and of potential manipulation with respect to this interpretation. Simulation results suggest that for the proposed system ties are unlikely to be a problem, but that there is at least potential for manipulation, of a novel type. We formalise this conception of manipulation axiomatically. The strongest axioms lead to an impossibility along the lines of Arrow's impossibility, while a small weakening leads to a possibility. We also provide a hardness result concerning the determination of possible manipulation.
CTAP: A Web-Based Tool Supporting Automatic Complexity Analysis
2019-05-08

Informed by research on readability and language acquisition, computational linguists have developed sophisticated tools for the analysis of linguistic complexity. While some tools are starting to become accessible on the web, there still is a disconnect between the features that can in principle be identified based on state-of-the-art computational linguistic analysis, and the analyses a teacher, textbook writer, or second language acquisition researcher can readily obtain and visualize for their own collection of texts. This short paper presents a web-based tool development that aims to meet this challenge. The Common Text Analysis Platform (CTAP) is designed to support fully configurable linguistic feature extraction for a wide range of complexity analyses. It features a user-friendly interface, modularized and reusable analysis component integration, and flexible corpus and feature management. Building on the Unstructured Information Management framework (UIMA), CTAP readily supports integration of state-of-the-art NLP and complexity feature extraction maintaining modularization and reusability. CTAP thereby aims at providing a common platform for complexity analysis, encouraging research collaboration and sharing of feature extraction components to jointly advance the state-of-the-art in complexity analysis in a form that readily supports real-life use by ordinary users.
Gender differences in chronotype diminish with age: a meta-analysis based on morningness/chronotype questionnaires
2019-05-09

Chronotype is an individual difference trait that is closely linked to biological variables. Usually, men and women differ in their chronotype with men being more evening oriented than women. The aim of the study was to assess gender differences in chronotype based on a systematic review and meta-analysis. In addition, many recent studies do not report gender differences any more although researchers collected data on men and women. This motivated us to contact many researchers directly to obtain and use these additional data. We included 164 studies giving 201 effect size measures in a data set, which only included the most commonly used questionnaires (MEQ, rMEQ and CSM) totaling 186,289 participants in total, of which 75,622 were men and 110,667 were women. We calculated an effect size of the standardized mean difference of -0.072 (95% CI from -0.062 to -0.082) in the fixed effects and of -0.066 (95% CI from -0.043 to- 0.089) in the random effects model. Men were on average more evening oriented than women. Type of questionnaire did not influence the standardized mean difference in chronotype between genders. Mean age, standard deviation of age and publication year (p ≤ 0.05) were found to have significant effects on the standardized mean difference in chronotype between genders. The standardized mean difference in chronotype between genders is predicted to change from negative to positive with increasing mean age (young women were more morning orientated than young men, but older women were less morning orientated than older men). This suggests that the differences between men and women diminish with time. The standardized mean difference in chronotype between genders is decreasing with increasing publication year, as well as with high variation in age of the samples. <b>Abbreviations:</b> CSM: Composite Scale of Morningness (Smith et al. 1989); MEQ: Morningness-Eveningness Questionnaire (Horne and Ostberg, 1976); rMEQ: reduced Morningness-Eveningness Questionnaire (Adan & Almiral, 1991); SMD: standardized mean difference (measure of effect size).