julilili42/papers huggingface dataset:
Socio-Economic Development and Violent Extremism in Morocco: Morocco's Regional Policy, Migration and (De-)Radicalization - Policy Briefs from the Region and Europe
2020-03-31

Similar to many other countries in the region, violent extremist groups and ideologies pose a significant threat to Moroccan society and the stability of the country. In response, the government has pursued a highly security-based approach, which has resulted in the arrest of over 3,000 (alleged) jihadis and the dismantling of 186 terrorist cells between 2002 and 2018. While the root causes are multi- faceted, Morocco’s ongoing socio-economic challenges, which have reinforced economic and political grievances, have fueled radicalization. For this reason, some have demanded that the government prioritize greater domestic engagement instead of increasing investment in countries south of the Sahara.
S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) – short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow‐up, prevention and occupational disease
2020-04-01

Summary Actinic keratoses (AKs) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence‐based framework for clinical decision making, the guidelines for actinic keratosis and cutaneous squamous cell carcinoma were developed using the highest level of methodology (S3) according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF). The guidelines are aimed at dermatologists, general practitioners, ENT specialists, surgeons, oncologists, radiologists and radiation oncologists in hospitals and office‐based settings as well as other medical specialties involved in the diagnosis and treatment of patients with AKs and cSCC. The guidelines are also aimed at affected patients, their relatives, policy makers and insurance funds. In the second part, we will address aspects relating to epidemiology, etiology, surgical and systemic treatment of cSCC, follow‐up and disease prevention, and discuss AKs and cSCC in the context of occupational disease regulations.
Improved constraints on parton distributions using LHCb, ALICE and HERA heavy-flavour measurements and implications for the predictions for prompt atmospheric-neutrino fluxes
2020-04-01

A bstract The impact of measurements of heavy-flavour production in deep inelastic ep scattering and in pp collisions on parton distribution functions is studied in a QCD analysis at next-to-leading order. Recent combined results of inclusive and heavy-flavour produc- tion cross sections in deep inelastic scattering at HERA are investigated together with heavy-flavour production measurements at the LHC. Differential cross sections of charm- and beauty-hadron production measured by the LHCb collaboration at the centre-of-mass energies of 5, 7 and 13 TeV as well as the recent measurements of the ALICE experiment at the centre-of-mass energies of 5 and 7 TeV are explored. These data impose additional constraints on the gluon and the sea-quark distributions at low partonic fractions x of the proton momentum, down to x ≈ 10 − 6 . The impact of the resulting parton distribution function in the predictions for the prompt atmospheric-neutrino fluxes is studied.
Pharmacoresponse in Genetic Generalized Epilepsy: A Genome-Wide Association Study
2020-04-01

<b>Aim:</b> Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE). <b>Materials & methods:</b> We conducted a genome-wide association study (GWAS) of 3.3 million autosomal SNPs in 893 European subjects with GGE - responsive or nonresponsive to lamotrigine, levetiracetam and valproic acid. <b>Results:</b> Our GWAS of AED response revealed suggestive evidence for association at 29 genomic loci (p <10<sup>-5</sup>) but no significant association reflecting its limited power. The suggestive associations highlight candidate genes that are implicated in epileptogenesis and neurodevelopment. <b>Conclusion:</b> This first GWAS of AED response in GGE provides a comprehensive reference of SNP associations for hypothesis-driven candidate gene analyses in upcoming pharmacogenetic studies.
Evidence for Magnetar Precession in X-Ray Afterglows of Gamma-Ray Bursts
2020-04-01

Abstract Many gamma-ray bursts are followed by periods of extended emission. At least in some cases, the burst afterglow may be powered by a rapidly rotating, highly magnetized neutron star, which spins down due to electromagnetic and gravitational-wave emission. Such a remnant is likely to strongly precess in the early stages of its life, which would lead to modulations in the X-ray luminosity as the triaxiality of the system evolves over time. Using a radiation profile appropriate for a precessing, oblique rotator, we find that Swift-XRT data of a long (080602) and a short (090510) burst matches the model with significantly higher accuracy (mean-square residuals dropping by ≳200% in the early stages of the extended emission) than for an orthogonal rotator. We interpret this as evidence for precession in newborn magnetars.
High frequency social calls indicate food source defense in foraging Common pipistrelle bats
2020-04-01

Abstract Social calls have the function to coordinate the behavior of animals. In the presence of conspecifics foraging Common pipistrelle bats ( P. pipistrellus) emitted, in addition to typical echolocation signals, two types of social calls: complex social calls and an as-of-yet undescribed, short, frequency-modulated call type with high terminal frequency, which we term “high frequency social call”. By recording the flight and acoustic behavior of free flying pairs of foraging P. pipistrellus with an array of four microphones we were able to determine their three-dimensional flight paths and attribute emitted calls to particular behavioral situations. Complex social calls were emitted at further inter-individual distances and at large bearing angles to conspecifics, whereas high frequency social calls were produced at significantly shorter distances and at smaller bearing angles. These calls were associated with chasings and the eviction of the intruder. We assume that the emission of both types of social calls by foraging bats reflects a two-stage-process of the occupation and defense of a food patch. Common pipistrelle bats use complex social calls to claim a food patch and switch to agonistic behaviors, including chasings and high frequency social call emissions, when they defend their foraging territory against an intruder.
Development of Interest and Role of Choice During Sequential Knowledge Acquisition
2020-04-01

Interest is an important motivational element for learning in the school environment. However, little research has directly addressed how interest changes over time as knowledge accumulates. To gain a better understanding of how knowledge acquisition influences intraindividual change of interest, we developed a novel paradigm in which participants gain step-by-step information about lesser known countries. After reading each piece of information, participants rated their interest in the country. Growth-curve modelling showed that interest grows during knowledge acquisition until it eventually stalls and starts to decline. We also found that the opportunity to choose information boosted the growth in interest and delayed its decline. Further analysis revealed that people disengaged from a topic (i.e., stopped accessing information about a particular country) when their interest started to decrease.
Update Breast Cancer 2020 Part 2 – Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics
2020-04-01

Abstract For patients with locally advanced or metastatic breast cancer, new and effective therapies such as CDK4/6 inhibitors, PARP inhibitors and a PD-L1 inhibitor have been introduced in recent years. This review presents an update on the available studies with their data. In addition, two innovative anti-HER2 therapies are presented (trastuzumab-deruxtecan and tucatinib) for which the results from new studies have been reported. Molecular tests offer the possibility of defining patient populations or also monitoring courses of therapy. This can help identify patients with specific characteristics in order to provide them with individually targeted therapy within the framework of studies. In a large study, the benefit of such a biomarker study was able to be described for the first time.
Unsupervised Adversarial Correction of Rigid MR Motion Artifacts
2020-04-01

Motion is one of the main sources for artifacts in magnetic resonance (MR) images. It can have significant consequences on the diagnostic quality of the resultant scans. Previously, supervised adversarial approaches have been suggested for the correction of MR motion artifacts. However, these approaches suffer from the limitation of required paired co-registered datasets for training which are often hard or impossible to acquire. Building upon our previous work, we introduce a new adversarial framework with a new generator architecture and loss function for the unsupervised correction of severe rigid motion artifacts in the brain region. Quantitative and qualitative comparisons with other supervised and unsupervised translation approaches showcase the enhanced performance of the introduced framework.
Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer
2020-04-01

Abstract More than ten years ago, the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) set up a panel of experts (VUS Task Force) which was tasked with reviewing the classifications of genetic variants reported by individual centres of the GC-HBOC to the central database in Leipzig and reclassifying them, where necessary, based on the most recent data. When it evaluates variants, the VUS Task Force must arrive at a consensus. The resulting classifications are recorded in a central database where they serve as a basis for ensuring the consistent evaluation of previously known and newly identified variants in the different centres of the GC-HBOC. The standardised VUS evaluation by the VUS Task Force is a key element of the recall system which has also been set up by the GC-HBOC. The system will be used to pass on information to families monitored and managed by GC-HBOC centres in the event that previously classified variants are reclassified based on new information. The evaluation algorithm of the VUS Task Force was compiled using internationally established assessment methods (IARC, ACMG, ENIGMA) and is presented here together with the underlying evaluation criteria used to arrive at the classification decision using a flow chart. In addition, the characteristics and special features of specific individual risk genes associated with breast and/or ovarian cancer are discussed in separate subsections. The URLs of relevant databases have also been included together with extensive literature references to provide additional information and cover the scope and dynamism of the current state of knowledge on the evaluation of genetic variants. In future, if criteria are updated based on new information, the update will be published on the website of the GC-HBOC (https://www.konsortium-familiaerer-brustkrebs.de/).
Comparison of Fast-Reroute Mechanisms for BIER-Based IP Multicast
2020-04-01

IP multicast (IPMC) delivers one-to-many traffic along distribution trees. To that end, conventional IPMC requires state in forwarding devices for each IPMC group. This limits scalability of IPMC because forwarding state in core devices may be extensive and updates are necessary when IPMC groups or the topology change. The IETF introduced Bit Index Explicit Replication (BIER) for efficient transport of IPMC traffic. BIER leverages a BIER header and IPMC-group-independent forwarding tables for forwarding of IPMC packets in a BIER domain. However, legacy devices do not support BIER. In contrary, two SDN-based implementations for OpenFlow an P4 have been published recently. In this paper, we assess BIER forwarding which may be affected by network failures. So far there is no standardized procedure to handle such situations. Two concepts have been proposed. The first approach is based on Loop- Free Alternates. It reroutes traffic to suitable neighbors in the BIER domain to steer traffic around the failure. The second approach is a tunnel-based mechanism that tunnels BIER packets to appropriate downstream nodes within the BIER distribution tree. We explain and compare both approaches, and discuss their advantages and disadvantages.
LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells
2020-04-01

LEFTY2 (endometrial bleeding associated factor; EBAF or LEFTYA), a cytokine released shortly before menstrual bleeding, is a negative regulator of cell proliferation and tumour growth. LEFTY2 down-regulates Na+/H+ exchanger activity with subsequent inhibition of glycolytic flux and lactate production in endometrial cancer cells. Glucose can be utilized not only for glycolysis but also for glycogen formation. Both glycolysis and glycogen formation require cellular glucose uptake which could be accomplished by the Na+ coupled glucose transporter-1 (SGLT1; SLC5A1). The present study therefore explored whether LEFTY2 modifies endometrial SGLT1 expression and activity as well as glycogen formation. Ishikawa and HEC1a cells were exposed to LEFTY2, SGLT1 and glycogen synthase (GYS1) transcript levels determined by qRT-PCR. SGLT1, GYS1 and phospho-GYS1 protein abundance was quantified by western blotting, cellular glucose uptake from 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose (2-NBDG) uptake, and cellular glycogen content utilizing an enzymatic assay and subsequent colorimetry. As a result, a 48-hour treatment with LEFTY2 significantly increased SGLT1 and GYS1 transcript levels as well as SGLT1 and GYS1 protein abundance in both Ishikawa and HEC1a cells. 2-NBDG uptake and cellular glycogen content were upregulated significantly in Ishikawa (type 1) but not in type 2 endometrial HEC1a cells, although there was a tendency of increased 2-NBDG uptake. Further, none of the effects were seen in human benign endometrial cells (HESCs). Interestingly, in both Ishikawa and HEC1a cells, a co-treatment with TGF-β reduced SGLT1, GYS and phospho-GYS protein levels, and thus reduced glycogen levels and again HEC1a cells had no significant change. In conclusion, LEFTY2 up-regulates expression and activity of the Na+ coupled glucose transporter SGLT1 and glycogen synthase GYS1 in a cell line specific manner. We further show the treatment with LEFTY2 fosters cellular glucose uptake and glycogen formation and TGF-β can negate this effect in endometrial cancer cells.
<p>Defining Criteria for Guiding Cancer Patients to Find a Reputable Complementary Medicine Provider: Results of a Literature Review and a Consensus Procedure</p>
2020-04-01

Purpose: Even in cases of positive evidence for complementary medicine (CM) therapies, it is still difficult for cancer patients to identify reputable providers. The aim of this study was to develop and evaluate a criteria list to provide guidance to cancer patients seeking a reputable CM provider. Methods: The design combined a literature review, an expert consensus procedure (n=15) and an assessment from three stakeholder perspectives (patients (n=18), CM providers (n=26) and oncology physicians (n=20)). Results: A total of 30 existing CM criteria were extracted from the literature, and 12 more were added by the experts. The main challenge was to define criteria that could easily be applied by the patients. A final comprehensive list of 8 criteria guiding cancer patients to find a reputable CM provider was developed. Conclusion: Health professionals and cancer information services might find the criteria list helpful when aiming to strengthen patients' awareness of quality-related factors associated with CM providers. The criteria developed might be helpful when standards are established for quality assurance in CM in oncology.
Feasibility of Eye Movement Recordings with the SMI Tracking Bar in 10- to 11-Year-Old Children Performing a Reading Task
2020-04-01

Abstract Introduction Eye movements during reading can be impaired in amblyopia, developmental dyslexia, reduced visual acuity, or visual field defects. To detect pathology, normative values are important for comparison. In healthy children, there is sparse data on eye movements during reading. Therefore, the aim of this study was to, in a first step, explore the feasibility of applying the SMI RED eye tracker bar to record eye movements in 10- and 11-year-old children while reading a text. Materials and Methods Thirty-three (19 aged 10 years, 14 aged 11 years) normally sighted children attending a primary school in Switzerland participated in our study. Visual acuity, the Lang test, and the cover test were performed as a screening for ophthalmologic pathology that might influence the results. Eye movements were recorded with the SMI RED eye tracker bar while the child read aloud two texts from the International Reading Speed Test (IReST), presented on a laptop. Both texts were in German with an equal level of difficulty and were presented in a randomized order. Reading speed (words/minute), number of saccades, number of fixations, and reading errors (mistakes in the reading) were evaluated. Results Screening did not reveal pathology other than refractive errors and children had full corrected visual acuity. Eye movements could be obtained in all but six children where the reflection of the glasses worn prevented a good pupil recording with the tracker. Younger children performed more saccades per word with a mean of 1.41 (SD 0.39) at 10 years of age versus 1.10 (SD 0.21) at 11 years of age. The number of fixations per word was also higher in younger children (mean: 1.63 [SD 0.37]) than in 11-year-old children (mean: 1.32 [SD 0.33]). Ten-year-old children seem to analyze a text in smaller units than 11-year-olds. Thus, 10-year-old children took more time to complete the reading task than the 11-year-olds (mean: 88.8 s [SD 24.1] versus 84.4 s [SD 15.1]). In addition, 10-year-old children made more reading errors compared to 11-year-olds (mean: 4.47 [SD 2.95] versus 2.28 [SD 1.72]). Conclusion It is feasible to record eye movements in children aged 10 – 11, albeit this is more difficult when glasses are worn. As parameters change with age, further data is needed for a representative evaluation regarding eye movements during reading in children of different age groups. The information gained may offer help in recognizing reading difficulties and monitoring of treatment effects.
xRAC: Execution and Access Control for Restricted Application Containers on Managed Hosts
2020-04-01

We propose xRAC to permit users to run special applications on managed hosts\\nand to grant them access to protected network resources. We use restricted\\napplication containers (RACs) for that purpose. A RAC is a virtualization\\ncontainer with only a selected set of applications. Authentication verifies the\\nRAC user's identity and the integrity of the RAC image. If the user is\\npermitted to use the RAC on a managed host, launching the RAC is authorized and\\naccess to protected network resources may be given, e.g., to internal networks,\\nservers, or the Internet. xRAC simplifies traffic control as the traffic of a\\nRAC has a unique IPv6 address so that it can be easily identified in the\\nnetwork. The architecture of xRAC reuses standard technologies, protocols, and\\ninfrastructure. Those are the Docker virtualization platform and 802.1X\\nincluding EAP-over-UDP and RADIUS. Thus, xRAC improves network security without\\nmodifying core parts of applications, hosts, and infrastructure. In this paper,\\nwe review the technological background of xRAC, explain its architecture,\\ndiscuss selected use cases, and investigate on the performance. To demonstrate\\nthe feasibility of xRAC, we implement it based on standard components with only\\na few modifications. Finally, we validate xRAC through experiments.\\n
Rotation-invariant clustering of neuronal responses in primary visual cortex
2020-04-01

Similar to a convolutional neural network (CNN), the mammalian retina encodes visual information into several dozen nonlinear feature maps, each formed by one ganglion cell type that tiles the visual space in an approximately shift-equivariant manner. Whether such organization into distinct cell types is maintained at the level of cortical image processing is an open question. Predictive models building upon convolutional features have been shown to provide state-of-the-art performance, and have recently been extended to include rotation equivariance in order to account for the orientation selectivity of V1 neurons. However, generally no direct correspondence between CNN feature maps and groups of individual neurons emerges in these models, thus rendering it an open question whether V1 neurons form distinct functional clusters. Here we build upon the rotation-equivariant representation of a CNN-based V1 model and propose a methodology for clustering the representations of neurons in this model to find functional cell types independent of preferred orientations of the neurons. We apply this method to a dataset of 6000 neurons and visualize the preferred stimuli of the resulting clusters. Our results highlight the range of non-linear computations in mouse V1.
Abnormal Placentation and Umbilical Cord Insertion
2020-04-01

Abstract In the last decades, abnormal placentation and umbilical cord insertion have become an increasingly relevant and feared pathology in obstetrics with increased morbidity and mortality for mother and child. In addition to several increasingly common risk factors, such as assisted reproduction, the main reason for the increased occurrence is the greater frequency of Cesarean sections. Correct diagnosis, which is primarily determined sonographically, is essential for targeted perinatal management. In particular, the diagnostic criteria and current management recommendations are described in the following article.