julilili42/papers huggingface dataset:
Alkaline-Silicate REE-HFSE Systems
2022-06-29

Abstract Development of renewable energy infrastructure requires critical raw materials, such as the rare earth elements (REEs, including scandium) and niobium, and is driving expansion and diversification in their supply chains. Although alternative sources are being explored, the majority of the world’s resources of these elements are found in alkaline-silicate rocks and carbonatites. These magmatic systems also represent major sources of fluorine and phosphorus. Exploration models for critical raw materials are comparatively less well developed than those for major and precious metals, such as iron, copper, and gold, where most of the mineral exploration industry continues to focus. The diversity of lithologic relationships and a complex nomenclature for many alkaline rock types represent further barriers to the exploration and exploitation of REE-high field strength element (HFSE) resources that will facilitate the green revolution. We used a global review of maps, cross sections, and geophysical, geochemical, and petrological observations from alkaline systems to inform our description of the alkaline-silicate REE + HFSE mineral system from continental scale (1,000s km) down to deposit scale (~1 km lateral). Continental-scale targeting criteria include a geodynamic trigger for low-degree mantle melting at high pressure and a mantle source enriched in REEs, volatile elements, and alkalies. At the province and district scales, targeting criteria relate to magmatic-system longevity and the conditions required for extensive fractional crystallization and the residual enrichment of the REEs and HFSEs. A compilation of maps and geophysical data were used to construct an interactive 3-D geologic model (25-km cube) that places mineralization within a depth and horizontal reference frame. It shows typical lithologic relationships surrounding orthomagmatic REE-Nb-Ta-Zr-Hf mineralization in layered agpaitic syenites, roof zone REE-Nb-Ta mineralization, and mineralization of REE-Nb-Zr associated with peralkaline granites and pegmatites. The resulting geologic model is presented together with recommended geophysical and geochemical approaches for exploration targeting, as well as mineral processing and environmental factors pertinent for the development of mineral resources hosted by alkaline-silicate magmatic systems.
A 32‐element loop/dipole hybrid array for human head imaging at 7 T
2022-06-29

Purpose To improve whole‐brain SNR at 7 Tesla, a novel 32‐element hybrid human head array coil was developed, constructed, and tested. Methods Our general design strategy is based on 2 major ideas: Firstly, following suggestions of previous works based on the ultimate intrinsic SNR theory, we combined loops and dipoles for improvement of SNR near the head center. Secondly, we minimized the total number of array elements by using a hybrid combination of transceive (TxRx) and receive (Rx) elements. The new hybrid array consisted of 8 folded‐end TxRx‐dipole antennas and 3 rows of 24 Rx‐loops all placed in a single layer on the surface of a tight‐fit helmet. Results The developed array significantly improved SNR in vivo both near the center (∼20%) and at the periphery (∼20% to 80%) in comparison to a common commercial array coil with 8 transmit (Tx) and 32 Rx‐elements. Whereas 24 loops alone delivered central SNR very similar to that of the commercial coil, the addition of complementary dipole structures provided further improvement. The new array also provided ∼15% higher Tx efficiency and better longitudinal coverage than that of the commercial array. Conclusion The developed array coil demonstrated advantages in combining complementary TxRx and Rx resonant structures, that is, TxRx‐dipoles and Rx‐loops all placed in a single layer at the same distance to the head. This strategy improved both SNR and Tx‐performance, as well as simplified the total head coil design, making it more robust.
Analysis of Fertility Preservation by Ovarian Tissue Cryopreservation in Pediatric Children in China
2022-06-29

Background Ovarian tissue cryopreservation (OTC) is the only method of fertility preservation (FP) in prepubertal girls, but the experience remains limited. This study investigates the effectiveness and feasibility of FP of OTC in children facing gonadotoxicity treatment in Chinese first ovarian tissue cryobank. Procedure OTC and evaluation of 49 children ≤14 years old in the cryobank of Beijing Obstetrics and Gynecology Hospital, Capital Medical University, from July 2017 to May 19, 2022, were analyzed retrospectively. We compared children’s general characteristics, follicle numbers, and hormone levels with and without chemotherapy before OTC. Results The age of 49 children at the time of OTC was 7.55 (1–14) years old. There were 23 cases of hematological non-malignant diseases, eight cases of hematological malignant diseases, four cases of gynecological malignant tumors, one case of neurological malignant tumors, one case of bladder cancer, five cases of sarcoma, three cases of mucopolysaccharidosis, one case of metachromatic leukodystrophy, two cases of dermatomyositis, one case of Turner’s syndrome. The median follicular count per 2-mm biopsy was 705. Age and AMH were not correlated (r = 0.084, P = 0.585). Age and follicle count per 2-mm biopsy was not correlated (r = −0.128, P = 0.403). Log10 (follicle count per 2-mm biopsy) and Log10 (AMH) were not correlated (r = −0.118, P = 0.456). Chemotherapy before OTC decreased AMH levels but had no significant effect on the number of follicles per 2-mm biopsy. Conclusions OTC is the only method to preserve the fertility of prepubertal girls, and it is safe and effective. Chemotherapy before OTC is not a contraindication to OTC.
Cancer risk and tumour spectrum in 172 patients with a germline SUFU pathogenic variation: a collaborative study of the SIOPE Host Genome Working Group
2022-06-29

Background Little is known about risks associated with germline SUFU pathogenic variants (PVs) known as a cancer predisposition syndrome. Methods To study tumour risks, we have analysed data of a large cohort of 45 unpublished patients with a germline SUFU PV completed with 127 previously published patients. To reduce the ascertainment bias due to index patient selection, the risk of tumours was evaluated in relatives with SUFU PV (89 patients) using the Nelson-Aalen estimator. Results Overall, 117/172 (68%) SUFU PV carriers developed at least one tumour: medulloblastoma (MB) (86 patients), basal cell carcinoma (BCC) (25 patients), meningioma (20 patients) and gonadal tumours (11 patients). Thirty-three of them (28%) had multiple tumours. Median age at diagnosis of MB, gonadal tumour, first BCC and first meningioma were 1.5, 14, 40 and 44 years, respectively. Follow-up data were available for 160 patients (137 remained alive and 23 died). The cumulative incidence of tumours in relatives was 14.4% (95% CI 6.8 to 21.4), 18.2% (95% CI 9.7 to 25.9) and 44.1% (95% CI 29.7 to 55.5) at the age of 5, 20 and 50 years, respectively. The cumulative risk of an MB, gonadal tumour, BCC and meningioma at age 50 years was: 13.3% (95% CI 6 to 20.1), 4.6% (95% CI 0 to 9.7), 28.5% (95% CI 13.4 to 40.9) and 5.2% (95% CI 0 to 12), respectively. Sixty-four different PVs were reported across the entire SUFU gene and inherited in 73% of cases in which inheritance could be evaluated. Conclusion Germline SUFU PV carriers have a life-long increased risk of tumours with a spectrum dominated by MB before the age of 5, gonadal tumours during adolescence and BCC and meningioma in adulthood, justifying fine-tuned surveillance programmes.
Maximal speed of propagation in open quantum systems
2022-06-29

We prove a maximal velocity bound for the dynamics of Markovian open quantum\\nsystems. The dynamics are described by one-parameter semi-groups of quantum\\nchannels satisfying the von Neumann-Lindblad equation. Our result says that\\ndynamically evolving states are contained inside a suitable light cone up to\\npolynomial errors. We also give a bound on the slope of the light cone, i.e.,\\nthe maximal propagation speed. The result implies an upper bound on the speed\\nof propagation of local perturbations of stationary states in open quantum\\nsystems.\\n
Political relations and sports: exploring the demand for relocated soccer games
2022-06-29

Research question In recent years, European soccer leagues have strengthened their internationalization efforts by relocating games abroad. In this context, we empirically investigate the impact of the political relations between the importing and the exporting countries on on-site demand for such games. While there is a rich literature addressing this issue in more general settings, it has never been explored in sports.Research methods We use a stated-preference approach and survey data of a representative sample of soccer-interested US residents, which we combine with data from the American Community Survey. The effects are estimated using Tobit regressions and an instrumental variable approach.Results and findings We find that the willingness-to-pay for admission to relocated games is higher if the country where the competing teams come from is perceived as friendly.Implications We provide preliminary empirical evidence that the political relations between importing and exporting countries may be important for international demand of spectator sports. As such, the public perception about political relations between countries may constitute a crucial component for sport leagues' expansion strategies.
Superior colliculus visual neural sensitivity at the lower limit of natural self-induced image displacements
2022-06-29

Abstract Visual pattern analysis relies on computations from neurons possessing spatially confined receptive fields. Often, such receptive fields are orders of magnitude larger than the visual pattern components being processed, as well as these components’ minute displacements on the retina, whether due to small object or self motions. Yet, perception effortlessly handles such visual conditions. Here, we show that in the primate superior colliculus, a brain structure long associated with oculomotor control, neurons with relatively large receptive fields are still sensitive to visual pattern displacements as small as 1 min arc. We used real-time gaze-contingent retinal image stabilization to control the instantaneous spatio-temporal luminance modulation of detailed patterns experienced by neurons, probing sensitivity to the lower limit of natural self-induced image displacements. Despite a large difference between pattern displacement amplitudes and receptive field sizes, collicular neurons were strongly sensitive to the visual pattern consequences of the smallest possible image-shifting eye movements.
Ballistic macroscopic fluctuation theory
2022-06-29

We introduce a new universal framework describing fluctuations and correlations in quantum and classical many-body systems, at the Euler hydrodynamic scale of space and time. The framework adapts the ideas of the conventional macroscopic fluctuation theory (MFT) to systems that support ballistic transport. The resulting "ballistic MFT" (BMFT) is solely based on the Euler hydrodynamics data of the many-body system. Within this framework, mesoscopic observables are classical random variables depending only on the fluctuating conserved densities, and Euler-scale fluctuations are obtained by deterministically transporting thermodynamic fluctuations via the Euler hydrodynamics. Using the BMFT, we show that long-range correlations in space generically develop over time from long-wavelength inhomogeneous initial states in interacting models. This result, which we verify by numerical calculations, challenges the long-held paradigm that at the Euler scale, fluid cells may be considered uncorrelated. We also show that the Gallavotti-Cohen fluctuation theorem for non-equilibrium ballistic transport follows purely from time-reversal invariance of the Euler hydrodynamics. We check the validity of the BMFT by applying it to integrable systems, and in particular the hard-rod gas, with extensive simulations that confirm our analytical results.
Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
2022-06-29

Introduction While oral glucose ingestion typically leads to a decrease in circulating glucagon levels, a substantial number of persons display stable or rising glucagon concentrations when assessed by radioimmunoassay (RIA). However, these assays show cross-reactivity to other proglucagon cleavage products. Recently, more specific assays became available, therefore we systematically assessed glucagon and other proglucagon cleavage products and their relation to metabolic health. Research Design and Methods We used samples from 52 oral glucose tolerance tests (OGTT) that were randomly selected from persons with different categories of glucose tolerance in an extensively phenotyped study cohort. Results Glucagon concentrations quantified with RIA were non-suppressed at 2 hours of the OGTT in 36% of the samples. Non-suppressor s showed lower fasting glucagon levels compared to suppressors (p=0.011). Similar to RIA measurements, ELISA-derived fasting glucagon was lower in non-suppressors (p&amp;lt;0.001). Glucagon 1-61 as well as glicentin and GLP-1 kinetics were significantly different between suppressors and non-suppressors (p=0.004, p=0.002, p=0.008 respectively) with higher concentrations of all three hormones in non-suppressors . Levels of insulin, C-peptide, and free fatty acids were comparable between groups. Non-suppressors were leaner and had lower plasma glucose concentrations (p=0.03 and p=0.047, respectively). Despite comparable liver fat content and insulin sensitivity (p≥0.3), they had lower 2-hour post-challenge glucose (p=0.01). Conclusions Glucagon 1-61, glicentin and GLP-1 partially account for RIA-derived glucagon measurements due to cross-reactivity of the assay. However, this contribution is small, since the investigated proglucagon cleavage products contribute less than 10% to the variation in RIA measured glucagon. Altered glucagon levels and higher post-challenge incretins are associated with a healthier metabolic phenotype.
The Flickr frequency norms: what 17 years of images tagged online tell us about lexical processing
2022-06-29

Word frequency is one of the best predictors of language processing. Typically,word frequency norms are entirely based on natural-language text data, thusrepresenting what the literature typically refers to as purely linguistic experience. This study presents Flickr frequency norms as a novel word frequency measure from a domain-specific corpus inherently tied to extra-linguistic information: words used as image tags on social media. To obtain Flickr frequency measures, we exploited the photo-sharing platform Flickr Image (containing billions of photos) and extracted the number of uploaded images tagged with each of the words considered in the lexicon. Here we systematically examine the peculiarities of Flickr frequency norms and show that Flickr frequency is a hybrid metric, lying at the intersection between language and visual experience and with specific biases induced by being based on image-focused social media. Moreover, regression analyses indicate that Flickr frequency captures additional information beyond what is already encoded in existing norms of linguistic, sensorimotor, and affective experience. Therefore, these new norms capture aspects of language usage that are missing from traditional frequency measures: a portion of language usage capturing the interplay between language and vision, which, as this study demonstrates, has its own impact on word processing. The Flickr frequency norms are openly available on the Open Science Framework(https://osf.io/2zfs3/).
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer’s disease: associations with β-amyloid-PET, neurodegeneration and cognition
2022-06-29

Abstract Glial fibrillary acidic protein (GFAP) is a promising candidate blood-based biomarker for Alzheimer’s disease (AD) diagnosis and prognostication. The timing of its disease-associated changes, its clinical correlates, and biofluid-type dependency will influence its clinical utility. We evaluated plasma, serum, and CSF GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease. Plasma GFAP elevations appear a decade before expected symptom onset, after β-amyloid accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished β-amyloid-positive from β-amyloid-negative ADAD participants and showed a stronger relationship with β-amyloid load in asymptomatic than symptomatic ADAD. Higher plasma GFAP was associated with the degree and rate of neurodegeneration and cognitive impairment. Serum GFAP showed similar relationships, but these were less pronounced for CSF GFAP. Our findings support a role for plasma GFAP as a clinical biomarker for β-amyloid-associated cognitive deterioration in AD.
Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome – a randomized controlled multicenter trial
2022-06-29

Abstract Background. Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrome are unavailable. Therefore, we investigated whether inhaled prostacyclin would affect the oxygenation and survival of patients suffering from ARDS. Methods. We performed a prospective randomized controlled single-blind multicenter trial across Germany. The trial was conducted from March 2019 with final follow-up on 12th of August 2021. Patients with moderate to severe ARDS were included and randomized to receive either inhaled prostacyclin (3 times/day for 5 days) or sodium chloride. The primary outcome was the oxygenation index in the intervention and control groups on Day 5 of therapy. Secondary outcomes were mortality, secondary organ failure, disease severity and adverse events. Results. Of 707 patients approached 150 patients were randomized to receive inhaled prostacyclin (n = 73) or sodium chloride (n = 77). Data from 144 patients were analyzed. The baseline oxygenation index did not differ between groups. The primary analysis of the study was negative, and prostacyclin improved oxygenation by 20 mmHg more than NaCl (p = 0·17). Oxygenation was significantly improved in patients with ARDS who were COVID-19-positive (34 mmHg, p = 0·04). Mortality did not differ between groups. Secondary organ failure and adverse events were similar in the intervention and control groups. Conclusions. Although the primary result of our study was negative, our data suggest that inhaled prostacyclin might be a more beneficial treatment than standard care for patients with ARDS. Trial registration: The study was approved by the Institutional Review Board of the Research Ethics Committee of the University of Tübingen (899/2018AMG1) and the corresponding ethical review boards of all participating centers. The trial was also approved by the Federal Institute for Drugs and Medical Devices (BfArM, EudraCT No. 2016-003168-37) and registered at clinicaltrials.gov ( NCT03111212) on April 6th 2017.
Resourceful Event-Predictive Inference: The Nature of Cognitive Effort
2022-06-30

Pursuing a precise, focused train of thought requires cognitive effort. Even more effort is necessary when more alternatives need to be considered or when the imagined situation becomes more complex. Cognitive resources available to us limit the cognitive effort we can spend. In line with previous work, an information-theoretic, Bayesian brain approach to cognitive effort is pursued: to solve tasks in our environment, our brain needs to invest information, that is, negative entropy, to impose structure, or focus, away from a uniform structure or other task-incompatible, latent structures. To get a more complete formalization of cognitive effort, a resourceful event-predictive inference model (REPI) is introduced, which offers computational and algorithmic explanations about the latent structure of our generative models, the active inference dynamics that unfold within, and the cognitive effort required to steer the dynamics—to, for example, purposefully process sensory signals, decide on responses, and invoke their execution. REPI suggests that we invest cognitive resources to infer preparatory priors, activate responses, and anticipate action consequences. Due to our limited resources, though, the inference dynamics are prone to task-irrelevant distractions. For example, the task-irrelevant side of the imperative stimulus causes the Simon effect and, due to similar reasons, we fail to optimally switch between tasks. An actual model implementation simulates such task interactions and offers first estimates of the involved cognitive effort. The approach may be further studied and promises to offer deeper explanations about why we get quickly exhausted from multitasking, how we are influenced by irrelevant stimulus modalities, why we exhibit magnitude interference, and, during social interactions, why we often fail to take the perspective of others into account.
Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris
2022-06-30

The severe autoimmune blistering disease Pemphigus vulgaris (PV) is mainly caused by autoantibodies (IgG) against desmoglein (Dsg) 3 and Dsg1. The mechanisms leading to the development of blisters are not fully understood, but intracellular signaling seems to play an important role. Sheddases ADAM10 and ADAM17 are involved in the turnover of the desmosomal cadherin Dsg2 and ADAM10 has been shown to contribute to acantholysis in a murine pemphigus model. In the present study, we further examined the role of ADAM10 and ADAM17 both in keratinocyte adhesion and in the pathogenesis of PV. First, we found that inhibition of ADAM10 enhanced adhesion of primary human keratinocytes but not of immortalized keratinocytes. In dissociation assays, inhibition of ADAM10 shifted keratinocyte adhesion towards a hyperadhesive state. However, ADAM inhibition did neither modulate protein levels of Dsg1 and Dsg3 nor activation of EGFR at Y1068 and Y845. In primary human keratinocytes, inhibition of ADAM10, but not ADAM17, reduced loss of cell adhesion and fragmentation of Dsg1 and Dsg3 immunostaining in response to a PV1-IgG from a mucocutaneous PV patient. Similarly, inhibition of ADAM10 in dissociation assay decreased fragmentation of primary keratinocytes induced by a monoclonal antibody against Dsg3 and by PV-IgG from two other patients both suffering from mucosal PV. However, such protective effect was not observed in both cultured cells and ex vivo disease models, when another mucocutaneous PV4-IgG containing more Dsg1 autoantibodies was used. Taken together, ADAM10 modulates both hyperadhesion and PV-IgG-induced loss of cell adhesion dependent on the autoantibody profile.