julilili42/papers huggingface dataset:
From asynchronous states to Griffiths phases and back: Structural heterogeneity and homeostasis in excitatory-inhibitory networks
2024-04-04

Balanced neural networks, in which excitatory and inhibitory inputs compensate each other on average, give rise to a dynamical phase dominated by fluctuations called an asynchronous state, crucial for brain functioning. However, structural disorder, which is inherent to random networks, can hinder such an excitation-inhibition balance. Indeed, structural and synaptic heterogeneities can generate extended regions in phase space akin to critical points, called Griffiths phases, with dynamical features very different from those of asynchronous states. Here we study a simple neural-network model with tunable levels of heterogeneity able to display these two types of dynamical regimes, i.e., asynchronous states and Griffiths phases, putting them together within a single phase diagram. Using this simple model, we are able to emphasize the crucial role played by synaptic plasticity and homeostasis to reestablish balance in intrinsically heterogeneous networks. Overall, we shed light onto how diverse dynamical regimes, each with different functional advantages, can emerge from a given network as a result of self-organizing homeostatic mechanisms. Published by the American Physical Society 2024
Educational and occupational aspirations at the end of secondary school: The importance of regional labour-market conditions
2024-04-04

The transition from general schooling to vocational training or to the labour market marks a crucial threshold in the life course of young adults. It has been well documented that successful school-to-work transitions are influenced by (regional) labour-market conditions. However, what has been rather neglected is that before actual transitions take place, adolescents need to make plans and evaluate their wishes and choices against the background of existing constraints. (Regional) labour-market conditions are a part of such constraints. This paper complements previous research by focusing on the impact of the regional labour market on students’ educational and occupational aspirations before school-to-work transitions take place. Regionalised administrative data on unemployment is linked with survey data from the Starting Cohort 4 of the German National Educational Panel Study (NEPS-SC4). Results indicate that a relatively higher level of regional unemployment is associated with aspirations for higher-status occupations. Their status aspiration push students towards continuing general school to obtain higher general qualifications. The effects vary with the attended secondary school track and with parents’ educational aspirations for their children.
Career path clustering of elite soccer players among European Big-5 nations utilizing Dynamic Time Warping
2024-04-04

Abstract Prior clustering approaches of soccer players have employed a variety of methods based on various data categories, but none of them have focused on clustering by career paths characterized through a time series analysis of yearly performance quality. Therefore, this study aims to propose a methodology how a career path can be represented as a time series of a player’s seasonal qualities and then be clustered with players that have a similar career path. The underlying data focuses on soccer players from the five largest European soccer nations (Big-5). This allows for the identification of different types of career paths of players and the investigation of significant disparities between career paths among the Big-5 nations. In line with our proposed methodological approach, we identified and interpreted 13 different clusters of player career paths. These range from the cluster with the highest player quality scores to the pattern comprising players with the weakest scores. Further, the detected clusters show significant differences regarding variables of soccer players’ early career phase in adolescence (e.g., age of debut in professional soccer, years spent in a youth academy). The presented approach might represent a first step for stakeholders in soccer to get an objective insight in players’ career by utilizing mainly freely available data sources.
Contrast Agents Based on Human Serum Albumin and Nitroxides for 1H-MRI and Overhauser-Enhanced MRI
2024-04-05

In cancer diagnostics, magnetic resonance imaging (MRI) uses contrast agents to enhance the distinction between the target tissue and background. Several promising approaches have been developed to increase MRI sensitivity, one of which is Overhauser dynamic nuclear polarization (ODNP)-enhanced MRI (OMRI). In this study, a macromolecular construct based on human serum albumin and nitroxyl radicals (HSA-NIT) was developed using a new synthesis method that significantly increased the modification to 21 nitroxide residues per protein. This was confirmed by electron paramagnetic resonance (EPR) spectroscopy and matrix-assisted laser desorption/ionization time-of-flight (MALDI ToF) mass spectrometry. Gel electrophoresis and circular dichroism showed no significant changes in the structure of HSA-NITs, and no oligomers were formed during modification. The cytotoxicity of HSA-NITs was comparable to that of native albumin. HSA-NITs were evaluated as potential “metal-free” organic radical relaxation-based contrast agents for 1H-MRI and as hyperpolarizing contrast agents for OMRI. Relaxivities (longitudinal and transversal relaxation rates r1 and r2) for HSA-NITs were measured at different magnetic field strengths (1.88, 3, 7, and 14 T). Phantoms were used to demonstrate the potential use of HSA-NIT as a T1- and T2-weighted relaxation-based contrast agent at 3 T and 14 T. The efficacy of 1H Overhauser dynamic nuclear polarization (ODNP) in liquids at an ultralow magnetic field (ULF, B0 = 92 ± 0.8 μT) was investigated for HSA-NIT conjugates. The HSA-NITs themselves did not show ODNP enhancement; however, under the proteolysis conditions simulating cancer tissue, HSA-NIT conjugates were cleaved into lower-molecular-weight (MW) protein fragments that activate ODNP capabilities, resulting in a maximum achievable enhancement |Emax| of 40–50 and a radiofrequency power required to achieve half of Emax, P1/2, of 21–27 W. The HSA-NIT with a higher degree of modification released increased the number of spin probes upon biodegradation, which significantly enhanced the Overhauser effect. Thus, HSA-NITs may represent a new class of MRI relaxation-based contrast agents as well as novel cleavable conjugates for use as hyperpolarizing contrast agents (HCAs) in OMRI.
The grain size of sediments delivered to steep debris‐flow prone channels prior to and following wildfire
2024-04-05

Abstract Debris flows are powered by sediment supplied from steep hillslopes where soils are often patchy and interrupted by bare‐bedrock cliffs. The role of patchy soils and cliffs in supplying sediment to channels remains unclear, particularly surrounding wildfire disturbances that heighten debris‐flow hazards by increasing sediment supply to channels. Here, we examine how variation in soil cover on hillslopes affects sediment sizes in channels surrounding the 2020 El Dorado wildfire, which burned debris‐flow prone slopes in the San Bernardino Mountains, California. We focus on six headwater catchments (&lt;0.1 km 2 ) where hillslope sources ranged from a continuous soil mantle to 95% bare‐bedrock cliffs. At each site, we measured sediment grain size distributions at the same channel locations before and immediately following the wildfire. We compared results to a mixing model that accounts for three distinct hillslope sediment sources distinguished by local slope thresholds. We find that channel sediment in fully soil‐mantled catchments reflects hillslope soils ( D 50 = 0.1–0.2 cm) both before and after the wildfire. In steeper catchments with cliffs, channel sediment is consistently coarse prior to fire ( D 50 = 6–32 cm) and reflects bedrock fracture spacing, despite cliffs representing anywhere from 5% to 95% of the sediment source area. Following the fire, channel sediment size reduces most (5‐ to 20‐fold) in catchments where hillslope sources are predominantly soil covered but with patches of cliffs. The abrupt fining of channel sediment is thought to facilitate postfire debris‐flow initiation, and our results imply that this effect is greatest where bare‐bedrock cliffs are present but not dominant. A patchwork of bare‐bedrock cliffs is common in steeplands where hillslopes respond to channel incision by landsliding. We show how local slope thresholds applied to such terrain aid in estimating sediment supply conditions before two destructive debris flows that eventually nucleated in these study catchments in 2022.
Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products
2024-04-05

Abstract A wide range of natural products important for the engineering and drug design of pharmaceuticals comprise largely of nitrogen-based heterocycles. Fungal natural products have proven to be a rich source of the industrially-important molecules, many of which are promising drug leads. Although, natural products containing a phthalimidine core tends not to be given distant classification, but compounds containing these structures exhibit antimicrobial, anthelmintic, antimalarial and insecticidal activities, and are among the potential target for discovering new drug candidates. Intriguingly, these are primarily isolated from fungal sources and to a very lesser extent from plants or bacteria. This review surveys fungal-derived phthalimidine metabolites published until the end of 2022, isolated from both terrestrial and aquatic or marine sources with emphasis on their unique chemistry, bioactivities, biogenesis and taxonomic classification. Their unique chemistry and diverse bioactivities (including antiviral, antiproliferative, antioxidant and antimicrobial) provide a chemical library with high medicinal potential, representing a treasure trove for synthetic chemists. Graphical Abstract
Positioning of pyrimidine motifs around cassette exons defines their PTB‐dependent splicing in Arabidopsis
2024-04-05

SUMMARY Alternative splicing (AS) is a complex process that generates transcript variants from a single pre‐mRNA and is involved in numerous biological functions. Many RNA‐binding proteins are known to regulate AS; however, little is known about the underlying mechanisms, especially outside the mammalian clade. Here, we show that polypyrimidine tract binding proteins (PTBs) from Arabidopsis thaliana regulate AS of cassette exons via pyrimidine (Py)‐rich motifs close to the alternative splice sites. Mutational studies on three PTB‐dependent cassette exon events revealed that only some of the Py motifs in this region are critical for AS. Moreover, in vitro binding of PTBs did not reflect a motif's impact on AS in vivo . Our mutational studies and bioinformatic investigation of all known PTB‐regulated cassette exons from A. thaliana and human suggested that the binding position of PTBs relative to a cassette exon defines whether its inclusion or skipping is induced. Accordingly, exon skipping is associated with a higher frequency of Py stretches within the cassette exon, and in human also upstream of it, whereas exon inclusion is characterized by increased Py motif occurrence downstream of said exon. Enrichment of Py motifs downstream of PTB‐activated 5′ splice sites is also seen for PTB‐dependent intron removal and alternative 5′ splice site events from A. thaliana , suggesting this is a common step of exon definition. In conclusion, the position‐dependent AS regulatory mechanism by PTB homologs has been conserved during the separate evolution of plants and mammals, while other critical features, in particular intron length, have considerably changed.
Good reasons for bad behavior: a randomized controlled experiment on the impact of narrative reading and writing on empathic concern, perspective-taking, and attitude
2024-04-05

Background Empathic concern and perspective-taking may contribute to avoiding stigmatization of adverse health behavior. Narrative writing has been shown to be effective in promoting perspective-taking and empathy. But since narrative writing is time consuming, we tested in the present study narrative reading as an alternative, more parsimonious approach. Methods In a randomized controlled experiment, we compared writing a narrative text about a fictitious person who displays disapproved of health behavior to reading such a text and to a control condition in which participants wrote about an unrelated topic. With a sample of n = 194 participants, we investigated the impact of writing and reading a narrative text on promoting empathic concern and perspective-taking as well as on attitude change. Results We found that both writing and reading a narrative text about the fictitious character increased empathic concern, F (1, 191) = 32.85, p &amp;lt; 0.001, part. η 2 = 0.15, and perspective-taking, F (1, 191) = 24.76, p &amp;lt; 0.001, part. η 2 = 0.12, more strongly than writing about an unrelated topic. Writing and reading a narrative text also resulted in a more positive attitude toward this person, F (1, 191) = 17.63, p &amp;lt; 0.001, part. η 2 = 0.08. Simply reading a narrative text was equally efficient as narrative writing with respect to empathic concern, p = 0.581, perspective-taking, p = 0.629, and attitude, p = 0.197. Conclusion The finding that narrative reading is as effective as narrative writing suggests that the readers appear to be able to comprehend and engage with the story being told. When narrative reading is as effective as narrative writing, it can succeed with reduced effort in increasing empathic concern, perspective-taking, and attitude. We discuss the benefits of this approach for reducing stigmatization of adverse health behavior.
A severe case of Plasmodium falciparum malaria in a traveler returning from Kazakhstan, a malaria-free country
2024-04-05

Following a 2-week trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was immediately treated with intravenous artesunate and transferred to an intensive care unit. The initial parasite density was as high as 30% infected erythrocytes with 845,880 parasites/μL. Since Kazakhstan was declared malaria-free in 2012, molecular testing for Plasmodium has been initiated to identify a possible origin. Genotyping of the msp-1 gene and microsatellite markers showed that the parasites are of African origin, with two different alleles indicating a polyclonal infection. After a hospitalization of 10 days, the patient was discharged in good health. Overall, our results emphasize that malaria must be on the list of differential diagnoses for patients with fever of unknown origin, even if they come from countries where malaria does not commonly occur.
AM‐301, a barrier‐forming nasal spray, versus saline spray in seasonal allergic rhinitis: A randomized clinical trial
2024-04-06

Abstract Rationale Saline nasal sprays are frequently used in the management of seasonal allergic rhinitis (SAR) for the cleansing and clearing of aeroallergens from the nasal cavity. Also using a drug‐free approach, AM‐301 nasal spray is forming a thin film barrier on the nasal mucosa to prevent contact with allergens, trap them, and facilitate their discharge. A clinical trial compared the efficacy, safety, and tolerability of AM‐301 and saline spray in SAR. Methods A total of 100 patients were randomized 1:1 to self‐administer AM‐301 or saline 3 × daily for 2 weeks. Primary efficacy endpoint: reduction in mean daily reflective Total Nasal Symptom Score (rTNSS). Secondary efficacy endpoints: reduction in mean instantaneous TNSS and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), global impression of efficacy. Safety and tolerability: adverse events, relief medication use, symptom‐free days, global impression of tolerability. Results AM‐301‐treated patients achieved a significantly lower rTNSS than the saline group (LS square means difference −1.1, 95% CI −1.959 to −0.241, p = .013) with improvement observed across all individual nasal symptoms. Likewise, all secondary endpoints showed statistical significance in favor of AM‐301; for example, quality of life was significantly improved overall ( p &lt; .001) as well as for each individual RQLQ domain. Both treatments showed similarly good safety and tolerability. With AM‐301, fewer patients used relief medication and more enjoyed symptom‐free days compared to saline treatment. Conclusions AM‐301 was more effective than saline in improving SAR nasal symptoms and related quality of life while offering similar tolerability, demonstrating the benefits of a barrier approach.
The impact of text topic and assumed human vs. AI authorship on competence and quality assessment
2024-04-06

While Large Language Models (LLMs) are considered positively with respect to technological progress and abilities, people are rather opposed to machines making moral decisions. But the circumstances under which algorithm aversion or algorithm appreciation are more likely to occur with respect to LLMs have not yet been sufficiently investigated. Therefore, the aim of this study was to investigate how texts with moral or technological topics, allegedly written either by a human author or by ChatGPT, are perceived.In a randomized controlled experiment, n=164 participants read six texts, three of which had a moral and three a technological topic (predictor text topic). The alleged author of each text was randomly either labeled “ChatGPT” or “human author” (predictor authorship). We captured three dependent variables: assessment of author competence, assessment of content quality, and participants’ intention to submit the text in a hypothetical university course (sharing intention). We hypothesized interaction effects, that is, we expected ChatGPT to score lower than human authors for moral topics and higher than human authors for technological topics and vice versa.In contrast to the hypotheses, we did not find any significant interaction effects. However, ChatGPT was consistently devalued compared to human authors across all dependent variables: There were main effects of authorship for assessment of the author competence, β=.78, t(326)=7.36, p&amp;lt;.001, d=0.81; for assessment of content quality, β=.30, t(326)=3.31, p&amp;lt;.001, d=0.37; as well as for sharing intention, β=.85, t(326)=5.07, p&amp;lt;.001, d=0.56. There was also a main effect of text topic on the assessment of text quality, β=.21, t(326)=2.35, p=.019, d=0.26. These results are rather in line with previous findings on algorithm aversion than with algorithm appreciation. We discuss the implications of these findings for the acceptance of the use of LLMs for text composition.
Me or we? Action-outcome learning in synchronous joint action
2024-04-06

Goal-directed behaviour requires mental representations that encode instrumental relationships between actions and their outcomes. The present study investigated how people acquire representations of joint actions where co-actors perform synchronized action contributions to produce joint outcomes in the environment. Adapting an experimental procedure to assess individual action-outcome learning, we tested whether co-acting individuals link jointly produced action outcomes to individual-level features of their own action contributions or to group-level features of their joint action instead. In a learning phase, pairs of participants produced musical chords by synchronizing individual key press responses. In a subsequent test phase, the previously produced chords were presented as imperative stimuli requiring forced-choice responses by both pair members. Stimulus-response mappings were systematically manipulated to be either compatible or incompatible with the individual and joint action-outcome mappings of the preceding learning phase. Only joint but not individual compatibility was found to modulate participants' performance in the test phase. Yet, opposite to predictions of associative accounts of action-outcome learning, jointly incompatible mappings between learning and test phase resulted in better performance. We discuss a possible explanation of this finding, proposing that pairs' group-level learning experience modulated how participants encoded ambiguous task instructions in the test phase. Our findings inform current debates about mechanistic explanations of action-outcome learning effects and provide novel evidence that joint action is supported by dedicated mental representations encoding own and others' actions on a group level.
NovoLign: metaproteomics by sequence alignment
2024-04-06

ABSTRACT Tremendous advances in mass spectrometric and bioinformatic approaches have expanded proteomics into the field of microbial ecology. The commonly used spectral annotation method for metaproteomics data relies on database searching, which requires sample-specific databases obtained from whole metagenome sequencing experiments. However, creating these databases is complex, time-consuming, and prone to errors, potentially biasing experimental outcomes and conclusions. This asks for alternative approaches that can provide rapid and orthogonal insights into metaproteomics data. Here we present NovoLign, a de novo metaproteomics pipeline that performs sequence alignment of de novo sequences from complete metaproteomics experiments. The pipeline enables rapid taxonomic profiling of complex communities and evaluates the taxonomic coverage of metaproteomics outcomes obtained from database searches. Furthermore, the NovoLign pipeline supports the creation of reference sequence databases for database searching to ensure comprehensive coverage. The NovoLign pipeline is publicly available via: https://github.com/hbckleikamp/NovoLign .
The human side of biodiversity: coevolution of the human niche, palaeo-synanthropy and ecosystem complexity in the deep human past
2024-04-07

Today's biodiversity crisis fundamentally threatens the habitability of the planet, thus ranking among the primary human challenges of our time. Much emphasis is currently placed on the loss of biodiversity in the Anthropocene, yet these debates often portray biodiversity as a purely natural phenomenon without much consideration of its human dimensions and frequently lack long-term vistas. This paper offers a deep-time perspective on the key role of the evolving human niche in ecosystem functioning and biodiversity dynamics. We summarize research on past hunter–gatherer ecosystem contributions and argue that human–environment feedback systems with important biodiversity consequences are probably a recurrent feature of the Late Pleistocene, perhaps with even deeper roots. We update current understandings of the human niche in this light and suggest that the formation of palaeo-synanthropic niches in other animals proffers a powerful model system to investigate recursive interactions of foragers and ecosystems. Archaeology holds important knowledge here and shows that ecosystem contributions vary greatly in relation to different human lifeways, some of which are lost today. We therefore recommend paying more attention to the intricate relationship between biodiversity and cultural diversity, contending that promotion of the former depends on fostering the latter. This article is part of the theme issue ‘Ecological novelty and planetary stewardship: biodiversity dynamics in a transforming biosphere’.