julilili42/papers huggingface dataset:
Conflicts around Germany’sEnergiewende: Discourse patterns of citizens’ initiatives
2017-12-01

Abstract Especially since the Fukushima nuclear catastrophe (2011), Germany has expanded its renewably sourced energies. Nuclear power is to be phased out by 2022. What is central to federal policy is the expansion of wind-generated energy. Plans for new wind farms have, however, faced opposition. And the transportation of electricity from the windy north to the high-use south entails an expansion of the existing power grid, which also provokes conflict. The article scrutinises dominant patterns of discourse on these issues. Based on current discourse theory, the research sheds light on the argumentative power of citizens’ initiatives with respect to nature conservation, landscape, health and economics.
Peritoneal innervation: embryology and functional anatomy
2017-12-01

Abstract The parietal peritoneum (PP) is innervated by somatic and visceral afferent nerves. PP receives sensitive branches from the lower intercostal nerves and from the upper lumbar nerves. Microscopically, a dense network of unmyelinated and myelinated nerve fibers can be found all over the PP. The unmyelinated fibers are thin and are ending just underneath the PP. The myelinated fibers can penetrate the PP to reach the peritoneal cavity, where they lose their myelin sheath and are exposed to somatic and nociceptive stimuli. PP is sensitive to pain, pressure, touch, friction, cutting and temperature. Noxious stimuli are perceived as a localized, sharp pain. The visceral peritoneum (VP) itself is not innervated, but the sub-mesothelial tissue is innervated by the autonomous nerve system. In contrast to the PP, the visceral submesothelium also receives fibers from the vagal nerve, in addition to the spinal nerves. VP responds primarily to traction and pressure; not to cutting, burning or electrostimulation. Painful stimuli of the VP are poorly localized and dull. Pain in a foregut structure (stomach, duodenum or biliary tract) is referred to the epigastric region, pain in a midgut structure (appendix, jejunum, or ileum) to the periumbilical area and pain from a hindgut source (distal colon or rectum) is referred to the lower abdomen or suprapubic region. Peritoneal adhesions can contain nerve endings. Neurotransmitters are acetylcholine, VIP, serotonin, NO, encephalins, CGRP and substance P. Chronic peritoneal pain can be exacerbated by neurogenic inflammation, e.g. by endometriosis.
Update Breast Cancer 2017 – Implementation of Novel Therapies
2017-12-01

Abstract In recent years, numerous new therapy options for patients with breast cancer have been developed in clinical studies, with some options already approved for routine treatment. As the speed at which innovations are introduced increases, the importance of conferences also increases, as conferences are where the data underpinning new therapies are usually presented for the first time. This review looks at publications of the ASCO (American Society of Clinical Oncology) and ESMO (European Society of Medical Oncology) conferences in 2017, summarizes them and evaluates them in the context of existing data. The focus is on new insights for neoadjuvant therapy and new treatment options in the metastatic setting, such as the use of CDK4/6 inhibitors or PARP inhibitors. The first results of treatments with checkpoint inhibitors are presented. With the patent expiry of trastuzumab, a number of study results for trastuzumab biosimilars have also been published. The digitization of patient care provides the first results on quality of life and prognosis of patients with advanced cancer. Digital communications between patients and physicians are being evaluated in several studies in Germany. As the discussion about patient-relevant endpoints for patients in the metastatic setting continues, overall survival rates from studies of big endocrine-based therapies are urgently needed. Preliminary analyses of small study cohorts offer initial insights. In the context of improving patient care, in the coming years, questions will center on which patients particularly benefit from certain therapies and which patients need particular protection from specific side effects. Questions about these predictors are raised in many scientific projects as attention increasingly focuses on this topic.
Progressive deafness–dystonia due to SERAC1 mutations: A study of 67 cases
2017-12-01

Objective 3‐Methylglutaconic aciduria, dystonia–deafness, hepatopathy, encephalopathy, Leigh‐like syndrome (MEGDHEL) syndrome is caused by biallelic variants in SERAC1 . Methods This multicenter study addressed the course of disease for each organ system. Metabolic, neuroradiological, and genetic findings are reported. Results Sixty‐seven individuals (39 previously unreported) from 59 families were included (age range = 5 days–33.4 years, median age = 9 years). A total of 41 different SERAC1 variants were identified, including 20 that have not been reported before. With the exception of 2 families with a milder phenotype, all affected individuals showed a strikingly homogeneous phenotype and time course. Severe, reversible neonatal liver dysfunction and hypoglycemia were seen in &gt;40% of all cases. Starting at a median age of 6 months, muscular hypotonia (91%) was seen, followed by progressive spasticity (82%, median onset = 15 months) and dystonia (82%, 18 months). The majority of affected individuals never learned to walk (68%). Seventy‐nine percent suffered hearing loss, 58% never learned to speak, and nearly all had significant intellectual disability (88%). Magnetic resonance imaging features were accordingly homogenous, with bilateral basal ganglia involvement (98%); the characteristic “putaminal eye” was seen in 53%. The urinary marker 3‐methylglutaconic aciduria was present in virtually all patients (98%). Supportive treatment focused on spasticity and drooling, and was effective in the individuals treated; hearing aids or cochlear implants did not improve communication skills. Interpretation MEGDHEL syndrome is a progressive deafness–dystonia syndrome with frequent and reversible neonatal liver involvement and a strikingly homogenous course of disease. Ann Neurol 2017;82:1004–1015
Multivalent-Ion-Activated Protein Adsorption Reflecting Bulk Reentrant Behavior
2017-12-01

Protein adsorption at the solid-liquid interface is an important phenomenon that often can be observed as a first step in biological processes. Despite its inherent importance, still relatively little is known about the underlying microscopic mechanisms. Here, using multivalent ions, we demonstrate the control of the interactions and the corresponding adsorption of net-negatively charged proteins (bovine serum albumin) at a solid-liquid interface. This is demonstrated by ellipsometry and corroborated by neutron reflectivity and quartz-crystal microbalance experiments. We show that the reentrant condensation observed within the rich bulk phase behavior of the system featuring a nonmonotonic dependence of the second virial coefficient on salt concentration c_{s} is reflected in an intriguing way in the protein adsorption d(c_{s}) at the interface. Our findings are successfully described and understood by a model of ion-activated patchy interactions within the framework of the classical density functional theory. In addition to the general challenge of connecting bulk and interface behavior, our work has implications for, inter alia, nucleation at interfaces.
Hybrid suburbia: New research perspectives in France and Southern California
2017-12-01

Abstract Geographical research on French and US suburbia has concentrated in recent decades on urban sprawl and concomitant processes of devaluation and exclusion. In the case of the French banlieues , with their much-publicised urban riots, this particular analytic focus has become overwhelming, with resultant loss to other developments and perspectives. However, certain districts in the first (or inner) ring of both French and US suburbia are currently showing distinct urbanisation tendencies in planning and architecture, evident in the new usage of brownfield sites and the ongoing demolition, replacement, and rededication of the older building core. Such processes induce population changes, e.g. the displacement of lower in favour of higher income groups. Overall, they result in an architectonic, social and cultural heterogeneity that escapes the specificity of received categories and merits the term hybridisation. The article describes and compares these processes as exemplified in Greater Paris and San Diego (Southern California).
Foraging and Roosting Behaviour of the Fringe-Lipped Bat, Trachops cirrhosus, on Barro Colorado Island, Panamá
2017-12-01

The Neotropical fringe-lipped bat, Trachops cirrhosus, is a generalist predator that hunts frogs and insects by homing in on their mating calls. Although research has examined cognition and prey preferences of bats in captivity, little is known of the foraging or roosting behaviour of this species in the wild. We radio tracked six T. cirrhosus individuals on Barro Colorado Island, Panamá. Bat day roosts were all in hollow cashew trees, Anacardium excelsum, in mixed sex groups of three to five T. cirrhosus individuals, with frequent roost switching. Radio tracked individuals flew an average of 218 ± 227 m from their day roosts to 12.0 ± 10.17 ha foraging areas (50% utilization distribution [UD] kernels = areas where bats spent 50% of their time as estimated from a probability distribution). These 50% UD kernels were less than 10% of their average total range use, but larger than previously reported for T. cirrhosus. Radio tracked individuals overlapped in 50% UD kernel foraging areas by only 2.1 ± 5.9 % on average. Foraging behaviour consisted predominantly of short sally flights of less than one minute, indicating bats were likely perch hunting. Bats were more frequently in flight, and had longer flight durations, at the beginning of the night and just before dawn than throughout the rest of the night. These data provide insight into the foraging behaviour of T. cirrhosus in the wild, that is a species fast becoming a model system of cognition in captivity.
Do they matter in education politics? The influence of political parties and teacher unions on school governance reforms in Spain
2017-12-01

This article focusses on the evolution of the school governance model in Spain since the 1980s. In Spain and elsewhere in Europe, the state's monopoly over education has softened and new forms of educational governance have emerged. This has resulted in the decentralization of decision-making authority to individual schools, municipalities, and regions and a significant increase in school autonomy. We explore from a political science perspective how partisan preferences and teachers unions have decisively shaped the reform trajectory. We show that leftist and center-right governments and different teachers' unions have promoted different versions of school autonomy in line with their ideological rationales, resulting in a reconfiguration of the school governance model with each change in government.
How to sequence video modeling examples and inquiry tasks to foster scientific reasoning
2017-12-01

Abstract Scientific reasoning skills can be acquired through technology-enhanced inquiry tasks or video modeling examples showing how to conduct virtual experiments. However, inquiry tasks can be cognitively demanding for novice learners, whereas video modeling examples can induce overconfidence. The present study investigated the effectiveness of both approaches in isolation and combination. We compared the effects of four groups (example-example, example-task, task-example and task-task) on learning outcomes, perceived difficulty and mental effort, judgments of learning, and monitoring accuracy among 107 seventh graders. In line with our hypotheses, watching a video modeling example first led to lower mental effort, better learning outcomes, and higher judgments of learning than solving an inquiry task first. Contrary to our hypotheses, all groups underestimated their performance. Results for mental effort and learning outcomes corroborate research on worked examples, whereas results for judgments of learning and monitoring accuracy indicate an underconfidence-with-practice effect.
Dual Energy Computed Tomography in Musculoskeletal Imaging, with Focus on Fragility Fractures of the Pelvis
2017-12-01

Abstract Dual energy computed tomography (DECT) is a constantly evolving technology, which opens up new diagnostic possibilities. It is particularly valuable for musculoskeletal (MSK) imaging. Due to the lack of recognition and availability of dual energy scanners, routine use is only established in a few centres. The intention of this review is to show the possibilities and fields of applications of the DECT in MSK imaging, as well as to describe technical principles and typical indications. We mainly focus on the use of DECT in the context of fragility fractures of the pelvis. The use of the DECT in pelvic fractures of the elderly could combine the advantages of CT diagnostics – fast and continuous availability, lower costs by dispensing with a supplementary MRI examination – and the high sensitivity of MRI to oedema in fragility fractures. Furthermore, the latest DECT scanners are dose neutral, so that these examinations can also be carried out without increased radiation exposure.
Non‐uniform splitting of a single mantle plume by double cratonic roots: Insight into the origin of the central and southern East African Rift System
2017-12-01

Abstract Using numerical thermo‐mechanical experiments we analyse the role of an active mantle plume and pre‐existing lithospheric thickness differences in the structural development of the central and southern East African Rift system. The plume‐lithosphere interaction model setup captures the essential features of the studied area: two cratonic bodies embedded into surrounding lithosphere of normal thickness. The results of the numerical experiments suggest that localization of rift branches in the crust is mainly defined by the initial position of the mantle plume relative to the cratons. We demonstrate that development of the Eastern branch, the Western branch and the Malawi rift can be the result of non‐uniform splitting of the Kenyan plume, which has been rising underneath the southern part of the Tanzanian craton. Major features associated with Cenozoic rifting can thus be reproduced in a relatively simple model of the interaction between a single mantle plume and pre‐stressed continental lithosphere with double cratonic roots.
Reduced‐Intensity Chemotherapy in Patients With Advanced‐Stage Hodgkin Lymphoma
2017-12-01

Abstract The international, randomized phase 3 HD15 trial established 6xeBEACOPP as standard therapy for patients with newly diagnosed advanced‐stage Hodgkin lymphoma (HL) within the German Hodgkin Study Group (GHSG). We performed a follow‐up analysis to assess long‐term efficacy and safety of this approach. Between 2003 and 2008, 2182 patients aged 18 to 60 years were recruited and randomized in a 1:1:1 ratio between 8 or 6 cycles of eBEACOPP or 8 cycles of the dose‐dense BEACOPP‐14 regimen, each followed by 30 Gy radiotherapy in case of positron emission tomography (PET)‐positive residual lesions ≥2.5 cm. The study aimed at demonstrating non‐inferiority regarding efficacy of the 2 experimental arms on a significance level of 2.5% each. The intention‐to‐treat analysis comprised 2126 patients with a median follow‐up of 102 months. Ten‐year progression‐free survival was 81% (97.5% CI 77–85) with 8xeBEACOPP, 84% (80–87) with 6xeBEACOPP, and 84% (80–87) with 8xBEACOPP‐14; the non‐inferiority margin of 1.51 for the hazard ratio (HR) could be excluded for both comparisons (6xeBEACOPP, HR = 0.7, 97.5% CI 0.5–1.0; 8xBEACOPP‐14, HR = 0.9, 97.5% CI 0.7–1.2). Overall survival at 10 years was 88% (85–91), 90% (88–93), and 92% (89–94), respectively. A total of 142 second malignancies corresponding to 10‐year cumulative incidences of 10%, 7%, and 7% and standardized incidence ratios of 4.3, 2.5, and 2.8 were reported for 8xeBEACOPP, 6xeBEACOPP, and 8xBEACOPP‐14, respectively. This updated analysis of the HD15 trial thus confirms the efficacy and reports on the long‐term safety of a shortened first‐line chemotherapy consisting of 6xeBEACOPP followed by PET‐guided radiotherapy in advanced‐stage HL.
Generalism in the interaction of Tulasnellaceae mycobionts with orchids characterizes a biodiversity hotspot in the tropical Andes of Southern Ecuador
2017-12-01

Biotic interactions play an important role in the assembly and stability of communities. All orchids depend on mycobionts for early establishment, but whether individual orchid species depend on a specific or broad spectrum of mycobionts is still a matter of debate. Tulasnellaceae (Basidiomycota) is the richest and most widespread mycobiont worldwide. We assessed Tulasnellaceae richness in epiphytic and terrestrial orchids in different habitats, and evaluated the degree of generalism in orchid-Tulasnellaceae interactions and the robustness of this mutualistic system to the extinction of mycobiont partners. We sampled 114 orchid individuals including all common and rare species in 56 plots of 1 m2 in 3 habitats: pristine forest, regenerating forest and a landslide site in a tropical montane rainforest in Southern Ecuador. We found 52 orchid and 29 Tulasnellaceae species. The composition of Tulasnellaceae OTUs was moderately to highly similar across habitats and between orchid growth forms. A significantly nested network architecture indicated the existence of a core of generalist Tulasnellaceae OTUs interacting with both rare and common orchids. Terrestrial and epiphytic orchids showed significant differences in robustness to the extinction of their Tulasnellaceae mycobionts. Thus, generalist mycobionts may be relevant for the preservation of hyperdiverse orchid communities in the tropics.
Gene Therapy Successfully Delays Degeneration in a Mouse Model ofPDE6A-Linked Retinitis Pigmentosa (RP43)
2017-12-01

Retinitis pigmentosa type 43 (RP43) is a blinding disease caused by mutations in the gene for rod phosphodiesterase 6 alpha (<i>PDE6A</i>). The disease process begins with a dysfunction of rod photoreceptors, subsequently followed by a currently untreatable progressive degeneration of the entire outer retina. Aiming at a curative approach via <i>PDE6A</i> gene supplementation, a novel adeno-associated viral (AAV) vector was developed for expression of the human <i>PDE6A</i> cDNA under control of the human rhodopsin promotor (rAAV8.PDE6A). This study assessed the therapeutic efficacy of rAAV8.PDE6A in the <i>Pde6a</i><sup>nmf363/nmf363</sup>-mutant mouse model of RP43. All mice included in this study were treated with sub-retinal injections of the vector at 2 weeks after birth. The therapeutic effect was monitored at 1 month and 6 months post injection. Biological function of the transgene was assessed <i>in vivo</i> by means of electroretinography. The degree of morphological rescue was investigated both <i>in vivo</i> using optical coherence tomography and <i>ex vivo</i> by immunohistological staining. It was found that the novel rAAV8.PDE6A vector resulted in a stable and efficient expression of PDE6A protein in rod photoreceptors of <i>Pde6a</i><sup>nmf363/nmf363</sup> mice following treatment at both the short- and long-term time points. The treatment led to a substantial morphological preservation of outer nuclear layer thickness, rod outer segment structure, and prolonged survival of cone photoreceptors for at least 6 months. Additionally, the ERG analysis confirmed a restoration of retinal function in a group of treated mice. Taken together, this study provides successful proof-of-concept for the cross-species efficacy of the rAAV8.PDE6A vector developed for use in human patients. Importantly, the data show stable expression and rescue effects for a prolonged period of time, raising hope for future translational studies based on this approach.
Transfer of an induced preferred retinal locus of fixation to everyday life visual tasks
2017-12-01

Subjects develop a preferred retinal locus of fixation (PRL) under simulation of central scotoma. If systematic relocations are applied to the stimulus position, PRLs manifest at a location in favor of the stimulus relocation. The present study investigates whether the induced PRL is transferred to important visual tasks in daily life, namely pursuit eye movements, signage reading, and text reading. Fifteen subjects with normal sight participated in the study. To develop a PRL, all subjects underwent a scotoma simulation in a prior study, where five subjects were trained to develop the PRL in the left hemifield, five different subjects on the right hemifield, and the remaining five subjects could naturally chose the PRL location. The position of this PRL was used as baseline. Under central scotoma simulation, subjects performed a pursuit task, a signage reading task, and a reading-text task. In addition, retention of the behavior was also studied. Results showed that the PRL position was transferred to the pursuit task and that the vertical location of the PRL was maintained on the text reading task. However, when reading signage, a function-driven change in PRL location was observed. In addition, retention of the PRL position was observed over weeks and months. These results indicate that PRL positions can be induced and may further transferred to everyday life visual tasks, without hindering function-driven changes in PRL position.
The Agricultural Landscape of Tel Burna: Ecology and Economy of a Bronze Age/Iron Age Settlement in the Southern Levant
2017-12-01

Abstract The Shephelah, known as the breadbasket of the southern Levant, is one of the more extensively investigated regions of the southern Levant in terms of archaeobotanical research. However, studies dealing with agriculture are scarce in comparison to the archaeobotanical data available. The analysis of the archaeobotanical assemblage in combination with the archaeological remains from Tel Burna will contribute to the investigation of the agriculture of the Shephelah. Several seasons of excavation revealed a cultic complex dating to the Late Bronze Age and an Iron Age II settlement with various agricultural installations such as silos and wine or olive presses. In this paper, we present the agricultural features in conjunction with the systematical archaeobotanical sampling, which enables us to reconstruct the types of crop plants cultivated at the site. Grass pea seeds dominate the assemblage collected from the Late Bronze Age complex, which may point to a connection to the Aegean. The Iron Age assemblage is distinguished by a significantly broad range of crop plants which were cultivated in vicinity of the tell. The archaeological Iron Age remains indicate that the processing of secondary products such as olive oil, wine, or textiles took place within the Iron Age settlement of Tel Burna. This first comprehensive overview describes the character of agricultural production in the Late Bronze Age to Iron Age environmental and geopolitical transformations.