julilili42/papers huggingface dataset:
Physical Domain Reconstruction with Finite Volume Neural Networks
2023-04-29

The finite volume neural network (FINN) is an exception among recent physics-aware neural network models as it allows the specification of arbitrary boundary conditions (BCs). FINN can generalize and adapt to various prescribed BC values not provided during training, where other models fail. However, FINN depends explicitly on given BC values and cannot deal with unobserved parts within the physical domain. To overcome these limitations, we extend FINN in two ways. First, we integrate the capability to infer BC values on-the-fly from just a few data points. This allows us to apply FINN in situations, where the BC values, such as the inflow rate of fluid into a simulated medium, are unknown. Second, we extend FINN to plausibly reconstruct missing data within the physical domain via a gradient-driven spin-up phase. Our experiments validate that FINN reliably infers correct BCs, but also generates smooth and plausible full-domain reconstructions that are consistent with the observable data. Moreover, FINN can generate precise predictions orders of magnitude more accurate compared to competitive pure ML and physics-aware ML models – even when the physical domain is only partially visible, and the BCs are applied at a point that is spatially distant from the observable volumes.
Differential survival of Staphylococcal species in macrophages
2023-04-29

The human pathogen Staphylococcus aureus is considered mainly an extracellular, opportunistic pathogen, yet the bacterium is able to survive within and escape from host cells, including macrophages. An agr / sae mutant of strain USA300 is unable to escape from human macrophages but can replicate and survive within macrophages. We questioned whether such “„non-toxic“” S. aureus resembles the less pathogenic coagulase-negative Staphylococcal species (CoNS) like S. carnosus , S. lugdunensis , S. capitis , S. warneri or S. pettenkoferi. We show that in contrast to the “„non-toxic“” S. aureus strains, the CoNS species are efficiently killed within 24 h post-infection in the macrophage-like THP-1 cells or in human primary macrophages. Bacterial persistence of “„non-toxic“” S . aureus or CoNS induced IL-1ß release but no cell-death. Mutations in genes coding for katalase, copprer transport or the regulatory system GraRS or SigB did not impact bacterial survival in THP-1 cells. Deletion of the superoxide dismutases sodA and sodM impaired S. aureus survival in human primary macrophages but not in THP-1 cells. However, expression of the S. aureus specific sodM in S. epidermidis was not sufficient to protect this species from being killed in THP-1 cells. Thus, at least in those cells better bacterial survival of S. aureus could not be linked to higher protection from ROS. However, “„non-toxic“” S. aureus was found to be insensitive to pH, whereas S. epidermidis was protected when phagosomal acidification was inhibited. Thus, species differences seem to be linked to different sensitivity to acidification.
X-Ray Polarization of BL Lacertae in Outburst
2023-05-01

Abstract We report the first &gt;99% confidence detection of X-ray polarization in BL Lacertae. During a recent X-ray/ γ -ray outburst, a 287 ks observation (2022 November 27–30) was taken using the Imaging X-ray Polarimetry Explorer (IXPE), together with contemporaneous multiwavelength observations from the Neil Gehrels Swift observatory and XMM-Newton in soft X-rays (0.3–10 keV), NuSTAR in hard X-rays (3–70 keV), and optical polarization from the Calar Alto and Perkins Telescope observatories. Our contemporaneous X-ray data suggest that the IXPE energy band is at the crossover between the low- and high-frequency blazar emission humps. The source displays significant variability during the observation, and we measure polarization in three separate time bins. Contemporaneous X-ray spectra allow us to determine the relative contribution from each emission hump. We find &gt;99% confidence X-ray polarization <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msub> <mml:mrow> <mml:mi mathvariant="normal">Π</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> <mml:mo>–</mml:mo> <mml:mn>4</mml:mn> <mml:mi>keV</mml:mi> </mml:mrow> </mml:msub> <mml:mo>=</mml:mo> <mml:msubsup> <mml:mrow> <mml:mn>21.7</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>7.9</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>+</mml:mo> <mml:mn>5.6</mml:mn> </mml:mrow> </mml:msubsup> <mml:mo>%</mml:mo> </mml:math> and electric vector polarization angle ψ 2–4keV = −28.°7 ± 8.°7 in the time bin with highest estimated synchrotron flux contribution. We discuss possible implications of our observations, including previous IXPE BL Lacertae pointings, tentatively concluding that synchrotron self-Compton emission dominates over hadronic emission processes during the observed epochs.
Bilateral inferior petrosal sinus sampling with human CRH stimulation in ACTH-dependent Cushing's syndrome: results from a retrospective multicenter study
2023-05-01

Abstract Objective Bilateral inferior petrosal sinus sampling (BIPSS) is regarded as the gold standard to differentiate between Cushing ́s disease (CD) and ectopic Cushing's syndrome (ECS). However, published data on the diagnostic value of additional prolactin analysis are controversial. Thus, we evaluated the diagnostic performance of BIPSS with and without prolactin in a multicenter study. Design and methods Retrospective study in five European reference centers. Patients with overt adrenocorticotropin (ACTH)-dependent Cushing's syndrome at the time of BIPSS with human corticotropin–releasing hormone stimulation were eligible. Cut-offs for the inferior petrosal sinus (IPS) to peripheral (P) ACTH ratio and the normalized ACTH:prolactin IPS:P ratio were calculated via receiver operator characteristic analyses (reference: CD). Results 156 patients with BIPSS were identified. Of these, 120 patients (92 [77%] females; 106 [88%] CD, 14 [12%] ECS) had either histopathologically confirmed tumors or biochemical remission and/or adrenal insufficiency after surgery; only this subgroup was analyzed by ROC analysis. The optimal cut-offs for the ACTH IPS:P ratio were ≥1.9 at baseline (sensitivity 82.1% [95% CI, 73.2-88.6], specificity 85.7% [95% CI, 56.2-97.5], AUC 0.86) and ≥2.1 at 5 minutes post-CRH (sensitivity 91.3% [95% CI, 83.6-95.7], specificity 92.9% [95% CI, 64.1-99.6], AUC 0.96). A subgroup underwent additional prolactin analysis. An optimal cut-off of ≥1.4 was calculated for the normalized ACTH:prolactin IPS:P ratio (sensitivity 96.0% [95% CI, 77.7-99.9], specificity 100% [95% CI, 56.1-100], AUC 0.99). Conclusion Our study confirms the high accuracy of BIPSS in the differential diagnosis of ACTH-dependent Cushing's syndrome and suggests that the simultaneous measurement of prolactin might further improve the diagnostic performance of this test.
Best practice in digital orthopaedics
2023-05-01

Digitization in orthopaedics and traumatology is an enormously fast-evolving field with numerous players and stakeholders. It will be of utmost importance that the different groups of technologists, users, patients, and actors in the healthcare systems learn to communicate in a language with a common basis. Understanding the requirements of technologies, the potentials of digital application, their interplay, and the combined aim to improve health of patients, would lead to an extraordinary chance to improve health care. Patients' expectations and surgeons’ capacities to use digital technologies must be transparent and accepted by both sides. The management of big data needs tremendous care as well as concepts for the ethics in handling data and technologies have to be established while also considering the impact of withholding or delaying benefits thereof. This review focuses on the available technologies such as Apps, wearables, robotics, artificial intelligence, virtual and augmented reality, smart implants, and telemedicine. It will be necessary to closely follow the future developments and carefully pay attention to ethical aspects and transparency.
Measuring language complexity: challenges and opportunities
2023-05-01

Abstract This special issue focuses on measuring language complexity. The contributions address methodological challenges, discuss implications for theoretical research, and use complexity measurements for testing theoretical claims. In this introductory article, we explain what knowledge can be gained from quantifying complexity. We then describe a workshop and a shared task which were our attempt to develop a systematic approach to the challenge of finding appropriate and valid measures, and which inspired this special issue. We summarize the contributions focusing on the findings which can be related to the most prominent debates in linguistic complexity research.
What do patients’ efficacy and tolerability ratings of acute migraine medication tell us? Cross-sectional data from the DMKG Headache Registry
2023-05-01

Background Most migraine patients need an effective acute medication. Real-world data can provide important information on the performance of acute migraine medication in clinical practice. Methods We used data from the German Migraine and Headache Society Headache Registry, where patients rate efficacy and tolerability of and satisfaction with each of their acute headache medications. Results A total of 1756 adult migraine patients (females: 85%, age: 39.5 ± 12.8 years, headache days per month: 13.5 ± 8.1) were included. Of these, 93% used acute medication, most frequently triptans (59.3%) and/or non-opioid analgesics (56.4%), and 58.5% rated efficacy as good or very good. This was more frequent for triptans (75.4%) than for non-opioid analgesics (43.6%, p &lt; 0.001). Among non-opioid analgesics, naproxen was rated most effective (61.9% very good or good, p &lt; 0.001 compared to ibuprofen, acetylsalicylic acid and paracetamol). Patient-rated efficacy significantly declined with higher headache frequencies (p &lt; 0.001), and this effect remained significant after omitting patients overusing acute medication. Conclusion In the present population recruited at specialized headache centers, patients rated triptans as more effective than non-opioid analgesics, naproxen as more effective than ibuprofen, and acute medication efficacy decreased with increasing headache frequency. Trial registration: The German Migraine and Headache Society Headache Registry is registered with the German Clinical Trials Register (DRKS 00021081).
Maintenance of biodiversity in multitrophic metacommunities: Dispersal mode matters
2023-05-01

Abstract Although metacommunity models generally formulate dispersal as a random, passive process, mounting evidence suggests that dispersal can be an active process depending on species fitness over the landscape, particularly in multitrophic communities. How different dispersal modes (i.e. from random to increasingly fitness‐dependent dispersal) modulate the effect of dispersal on biodiversity remains unclear. Here, we used a metacommunity model of food webs to investigate the effects of dispersal and habitat heterogeneity on biodiversity and how these effects may be dependent on dispersal mode. Our results showed that compared to isolated systems, random dispersal increased local food web diversity ( diversity) but decreased across‐community dissimilarity ( diversity) and regional food web diversity ( diversity), consistent with findings from competitive metacommunity models. However, fitness‐dependency could alter the effects of dispersal on biodiversity. Both and diversity increased with the strength of fitness‐dependency of dispersal, while diversity peaked at intermediate fitness‐dependency. Notably, strong fitness‐dependent dispersal maintained levels of and diversity similar to those observed in isolated systems. Thus, random dispersal and isolation (i.e. no dispersal) can be considered as two extremes along the continuum of fitness‐dependent dispersal, in terms of their effects on biodiversity. Moreover, both biodiversity‐habitat heterogeneity and biodiversity‐habitat connectivity relationships depended on the dispersal mode. Strikingly, under random dispersal, diversity decreased with habitat heterogeneity and connectivity, but under strong fitness‐dependent dispersal, it increased with habitat heterogeneity and remained unchanged as habitat connectivity increased. Our study highlights the context dependence of dispersal effects on biodiversity in heterogeneous landscapes. Our findings have useful implications for biodiversity conservation and landscape management, where management strategies should account for different modes of dispersal across taxa, thus different responses of biodiversity to habitat heterogeneity and connectivity.
Bending of the Western Mongolian Blocks Initiated the Late Triassic Closure of the Mongol‐Okhotsk Ocean and Formation of the Tuva‐Mongol Orocline
2023-05-01

Abstract Bending of ribbon continents or arcs is an important tectonic process for reconstructing central Asia. Formation of the striking Tuva‐Mongol Orocline by closure of the Mongol‐Okhotsk Ocean (MOO) has long been proposed, but coupling of the two geological events has not been well illustrated, hindering our understanding of tectonic evolution of central Asia. In order to constrain age of initial closure of the MOO in its western segment and formation of the Tuva‐Mongol Orocline, we performed paleomagnetic studies on the Late Triassic clastic rocks in the Amuria Block (AMB; 17 sites) and the Tarvagatay Block (TVB; 10 sites) of the western Mongolian blocks (WMB) on both sides of the Mongol‐Okhotsk Suture. Rock magnetic investigations show hematite and magnetite as main magnetic carriers of the characteristic remanent magnetization (ChRM). The ChRM directions from both regions pass fold and/or reversal tests and can be considered as primary remanent magnetization. Combining the overlapped new paleomagnetic poles (AMB: λ / φ = 70.4°N/233.8°E, A 95 = 4.6°; TVB: λ / φ = 70.5°N/248.2°E, A 95 = 9.0°) with geological evidence, we propose that the bending of the WMB following its collision with the Siberia Craton resulted in the Late Triassic closure of the MOO in its western segment, and initiated the formation of the Tuva‐Mongol Orocline.
Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau
2023-05-01

Objective Description of tuberculosis (TB)-focused point-of-care ultrasound (POCUS) findings for children with presumptive TB. Design Cross-sectional study (July 2019 to April 2020). Setting Simão Mendes hospital in Bissau, a setting with high TB, HIV, and malnutrition burdens. Participants Patients aged between 6 months and 15 years with presumptive TB. Interventions Participants underwent clinical, laboratory and unblinded clinician-performed POCUS assessments, to assess subpleural nodules (SUNs), lung consolidation, pleural and pericardial effusion, abdominal lymphadenopathy, focal splenic and hepatic lesions and ascites. Presence of any sign prompted a POCUS positive result. Ultrasound images and clips were evaluated by expert reviewers and, in case of discordance, by a second reviewer. Children were categorised as confirmed TB (microbiological diagnosis), unconfirmed TB (clinical diagnosis) or unlikely TB. Ultrasound findings were analysed per TB category and risk factor: HIV co-infection, malnutrition and age. Results A total of 139 children were enrolled, with 62 (45%) women and 55 (40%) aged &lt;5 years; 83 (60%) and 59 (42%) were severely malnourished (SAM) and HIV-infected, respectively. TB confirmation occurred in 27 (19%); 62 (45%) had unconfirmed TB and 50 (36%) had unlikely TB. Children with TB were more likely to have POCUS-positive results (93%) compared with children with unlikely TB (34%). Common POCUS signs in patients with TB were: lung consolidation (57%), SUNs (55%) and pleural effusion (30%), and focal splenic lesions (28%). In children with confirmed TB, POCUS sensitivity was 85% (95% CI) (67.5% to 94.1%). In those with unlikely TB, specificity was 66% (95% CI 52.2% to 77.6%). Unlike HIV infection and age, SAM was associated with a higher POCUS-positivity. Cohen’s kappa coefficient for concordance between field and expert reviewers ranged from 0.6 to 0.9. Conclusions We found a high prevalence of POCUS signs in children with TB compared with children with unlikely TB. POCUS-positivity was dependent on nutritional status but not on HIV status or age. TB-focused POCUS could potentially play a supportive role in the diagnosis of TB in children. Trial registration number NCT05364593 .
A Diffusion Model Analysis of Object-Based Selective Attention in the Eriksen Flanker Task
2023-05-01

Abstract. Selective attention might be space-, feature-, and/or object-based. Clear support for the involvement of an object-based mechanism is rather scarce, possibly because the predictions of models from these different classes often overlap. Yet, only object-based models can account for a larger congruency effect (CE) in the Eriksen flanker task when flankers are more (vs. less) strongly grouped to the target, but spacing and other response-irrelevant features of target and flankers are held constant. Exactly this was observed by Kramer and Jacobson (1991) . So far, this theoretically relevant finding has not been replicated closely. We replicated the finding in two web-based experiments. Specifically, CEs were larger when flanker lines were connected to the central target line (vs. to outer neutral lines). We also successfully fitted the Diffusion Model for Conflict tasks (DMC) to the experimental data. Critically, diffusion modeling (DMC) and distributional analyses (delta functions) revealed that object membership primarily affected target processing strength rather than strength or timing of flanker processing. This challenges the prominent attentional spreading (sensory enhancement) account of object-based selective attention and motivates an alternative target attenuation account.
The effect of maternal pregestational diabetes on fetal autonomic nervous system
2023-05-01

Abstract Heart rate variability assessment of neonates of pregestational diabetic mothers have shown alterations in the autonomic nervous system (ANS). The objective was to study the effect of maternal pregestational diabetes on ANS at the fetal stage by combining cardiac and movement parameters using a non‐invasive fetal magnetocardiography (fMCG) technique. This is an observational study with 40 participants where fetuses from a group of 9 Type 1, 19 Type 2 diabetic, and 12 non‐diabetic pregnant women were included. Time and frequency domain fetal heart rate variability (fHRV) and coupling of movement and heart rate acceleration parameters related to fetal ANS were analyzed. Group differences were investigated using analysis of covariance to adjust for gestational age (GA). When compared to non‐diabetics, the Type 1 diabetics had a 65% increase in average ratio of very low‐frequency (VLF) to low‐frequency (LF) bands and 63% average decrease in coupling index after adjusting for GA. Comparing Type 2 diabetics to non‐diabetics, there was an average decrease in the VLF (50%) and LF bands (63%). Diabetics with poor glycemic control had a higher average VLF/LF (49%) than diabetics with good glycemic control. No significant changes at p &lt; 0.05 were observed in high‐frequency (HF) frequency domain parameters or their ratios, or in the time domain. Fetuses of pregestational diabetic mothers exhibited some differences in fHRV frequency domain and heart rate‐movement coupling when compared to non‐diabetics but the effect of fHRV related to fetal ANS and sympathovagal balance were not as conclusive as observed in the neonates of pregestational diabetic mothers.
A flux-tunable YBa2Cu3O7 quantum interference microwave circuit
2023-05-01

Josephson microwave circuits are essential for the currently flourishing research on superconducting technologies, such as quantum computation, quantum sensing, and microwave signal processing. To increase the possible parameter space for device operation with respect to the current standards, many materials for superconducting circuits are under active investigation. Here, we present the realization of a frequency-tunable, weakly nonlinear Josephson microwave circuit made of the high-temperature cuprate superconductor YBa2Cu3O7 (YBCO), a material with a high critical temperature and a very high critical magnetic field. An in situ frequency-tunability of ∼300 MHz is achieved by integrating a superconducting quantum interference device (SQUID) into the circuit based on Josephson junctions directly written with a helium ion microscope (HIM). Our results demonstrate that YBCO-HIM-SQUID microwave resonators are promising candidates for quantum sensing and microwave technology applications.
Unconventional Fiscal Policy at Work
2023-05-01

In an effort to stabilize the economy during the COVID-19 pandemic, the German government reduced value-added taxes (VAT) by 3 percentage points for a period of six months in the latter half of 2020. This measure resulted in a boost in aggregate consumer spending on both durable and semidurable goods during the six-month period, with spending decreasing once the VAT reduction was reversed. The effect of the temporary VAT cut on durable spending was stronger than on semidurable spending. Additionally, the temporary VAT cut also stabilized, and even slightly increased, inflation expectations in the second half of 2020.
Using clay mineralogy and micropalaeontological observations to unravel Neogene climate variations in Northern Arabia
2023-05-01

Abstract The Zagros Mountain belt in Iran comprises an extensive record of Mesozoic and Cenozoic deposits uplifted by collision of the Arabian and Iranian continental plates. This area has been shown to provide important information to decipher the climatic history of Western Asia, especially regarding the evolution of deserts in Mesopotamia and Northern Arabia. In a high-resolution geological record of 84 samples, we combine clay mineralogy and micropalaeontological observations to refine the late Neogene climate record in Northern Arabia. We investigated a 2.6-km-thick sedimentary profile from the Simply Folded Zagros Mountain belt spanning ca. 10.2 myrs from the late Middle Miocene (Serravallian) to earliest Pleistocene (Gelasian) comprising floodplain sediments and saline mudstones with a strong aeolian contribution. The clay fraction &lt; 2 μm reveals palygorskite, smectite, illite, chlorite and the zeolite mineral erionite. Using clay mineralogy, arid conditions during the Serravallian and early Tortonian in Northern Arabia are identified, followed by semi-arid conditions during the late Tortonian. Clay mineralogy suggests a transition to sustained arid conditions during the early Messinian and provides a more complex picture on a previously proposed period of hyperaridity (NADX) in Northern Arabia penecontemporaneous with the apex of the Messinian salinity crisis.
Pulsar and Magnetar Navigation with Fermi/GBM and GECAM
2023-05-01

Abstract The determination of the absolute and relative position of a spacecraft is critical for its operation, observations, data analysis, scientific studies, as well as deep-space exploration in general. A spacecraft that can determine its own absolute position autonomously may perform better than those that must rely on transmission solutions. In this work, we report an absolute navigation accuracy of ∼20 km using 16 day Crab pulsar data observed with Fermi’s Gamma-ray Burst Monitor (GBM). In addition, we propose a new method with the inverse process of the triangulation for joint navigation using repeated bursts like those from the magnetar SGR J1935+2154 observed by the Gravitational-wave High-energy Electromagnetic Counterpart All-sky Monitor and GBM.