julilili42/papers huggingface dataset:
Direct Estimation of Equivalence Scales and More Evidence on Independence of Base
2017-06-18

Abstract We explore a direct approach to estimating household equivalence scales from income satisfaction data. Our method differs from previous approaches to using satisfaction data for this purpose in that it can be used to directly fit and evaluate closed‐form and non‐parametric equivalence scales of any desired form. Its flexibility makes it easy to consider specific aspects such as income dependence or more specific information on household composition (such as whether household members live in a partner relationship). We estimate and evaluate a number of scales used in the literature. If the equivalence scale is assumed to be independent of income and to depend only on household size, we do not reject the validity of the widely used square‐root scale at conventional significance levels. We also test GESE and GAESE restrictions (Donaldson and Pendakur, 2003, 2006) and investigate in detail to what extent household economies of scale depend on income. Our results suggest that the income dependence differs fundamentally across household types (rising economies of scale for ‘family’ households, falling economies of scale for multi‐adult households without children and no income dependence for other households).
Excited-State Deactivation Pathways and the Photocyclization of BN-Doped Polyaromatics
2017-06-18

Boron-nitrogen doping of polyaromatic hydrocarbons (PAH), such as borazine-core hexabenzocoronene, presents possibilities for tuning the properties of organic electronics and nanographene materials while preserving structural characteristics of pure hydrocarbons. Previous photochemical studies have demonstrated extension of a borazine-core PAH network (1,2:3,4:5,6-tris(o,o'-biphenylylene)borazine, 1) by photoinduced cyclodehydrogenation. We present steady-state and femtosecond-to-microsecond resolved spectroscopic studies of the photophysics of 1 and a related borazine-core PAH in order to characterize competing excited-state relaxation pathways that determine the efficacy of bond formation by photocyclization. Transient spectra evolve on time scales consistent with S<sub>1</sub> fluorescence lifetimes (1-3 ns) to features that persist onto microsecond time scales. Nanosecond-resolved oxygen-quenching measurements reveal that long-lived metastable states are triplets rather than cyclized products. Determination of fluorescence and triplet quantum yields reveal that photochemical bond formation is a minor channel in the relaxation of 1 (∼5% or less), whereas highly efficient fluorescence and intersystem crossing result in negligible photoinduced bond formation in more extended borazine-core networks. Results of computational investigations at the RICC2 level reveal sizable barriers to cyclization on the S<sub>1</sub> potential energy surfaces consistent with quantum yields deduced from experiment. Together these barriers and competing photophysical pathways limit the efficiency of photochemical synthesis of BN-doped polyaromatics.
Osteoblast migration in vertebrate bone
2017-06-19

ABSTRACT Bone formation, for example during bone remodelling or fracture repair, requires mature osteoblasts to deposit bone with remarkable spatial precision. As osteoblast precursors derive either from circulation or resident stem cell pools, they and their progeny are required to migrate within the three‐dimensional bone space and to navigate to their destination, i.e. to the site of bone formation. An understanding of this process is emerging based on in vitro and in vivo studies of several vertebrate species. Receptors on the osteoblast surface mediate cell adhesion and polarization, which induces osteoblast migration. Osteoblast migration is then facilitated along gradients of chemoattractants. The latter are secreted or released proteolytically by several cell types interacting with osteoblasts, including osteoclasts and vascular endothelial cells. The positions of these cellular sources of chemoattractants in relation to the position of the osteoblasts provide the migrating osteoblasts with tracks to their destination, and osteoblasts possess the means to follow a track marked by multiple chemoattractant gradients. In addition to chemotactic cues, osteoblasts sense other classes of signals and utilize them as landmarks for navigation. The composition of the osseous surface guides adhesion and hence migration efficiency and can also provide steering through haptotaxis. Further, it is likely that signals received from surface interactions modulate chemotaxis. Besides the nature of the surface, mechanical signals such as fluid flow may also serve as navigation signals for osteoblasts. Alterations in osteoblast migration and navigation might play a role in metabolic bone diseases such as osteoporosis.
The Relations Between Parental Socioeconomic Status, Personality, and Life Outcomes
2017-06-19

Studies have shown that cognitive ability is correlated with parental socioeconomic status (pSES). However, little is known about the correlation between personality and pSES. To better understand this relation, we conducted a meta-analysis of the correlations between pSES and personality traits and temperament dimensions. The correlations were generally very small with the exception of the correlation between pSES and openness to experience. Our results were replicated in a large ( N = 2,183,377) data set of self-reported personality scores collected online. Using this data set, we also examined the interaction between pSES and personality on attained education and socioeconomic status. We found evidence for the resource substitution hypothesis, which proposes that personality compensates for background disadvantage.
Apoptotic foci at mitochondria: in and around Bax pores
2017-06-19

The permeabilization of the mitochondrial outer membrane by Bax and Bak during apoptosis is considered a key step and a point of no return in the signalling pathway. It is always closely related to the reorganization of mitochondrial cristae that frees cytochrome c to the intermembrane space and to massive mitochondrial fragmentation mediated by the dynamin-like protein Drp1. Despite multiple evidence in favour of a functional link between these processes, the molecular mechanisms that connect them and their relevance for efficient apoptosis signalling remain obscure. In this review, we discuss recent progress on our understanding of how Bax forms pores in the context of Drp1-stabilized signalling platforms at apoptotic foci in mitochondria. This article is part of the themed issue ‘Membrane pores: from structure and assembly, to medicine and technology’.
Direct estimation of equivalence scales and more evidence on independence of base
2017-06-19

We explore a direct approach to estimating household equivalence scales from income satisfaction data. Our method differs from previous approaches to using satisfaction data for this purpose in that it can be used to directly fit and evaluate closed-form and non-parametric equivalence scales of any desired form. Its flexibility makes it easy to consider specific aspects such as income dependence or more specific information on household composition (such as whether household members live in a partner relationship). We estimate and evaluate a number of scales used in the literature. If the equivalence scale is assumed to be independent of income and to depend only on household size, we do not reject the validity of the widely used square-root scale at conventional significance levels. We also test GESE and GAESE restrictions (Donaldson and Pendakur, 2003, 2006) and investigate in detail to what extent household economies of scale depend on income. Our results suggest that the income dependence differs fundamentally across household types (rising economies of scale for ‘family’ households, falling economies of scale for multi-adult households without children and no income dependence for other households).
Molecular and Genetic Dissection of Cereal Root System Development
2017-06-19

Abstract Monocotyledonous cereal root systems have a complex organization and are composed of primary and seminal roots that are preformed during embryogenesis and roots that emerge postembryonically either from other roots (lateral roots) or from nodal structures of the shoot (shoot‐borne roots). In recent years, a number of specific mutants affected in cereal root system development, mainly in maize, rice and barley, have been identified. These mutants are impaired in root formation during embryogenesis, in primary root elongation, in root hair formation, in shoot‐borne root initiation and in lateral root initiation and elongation. Recently, for some of these mutants the corresponding genes have been cloned and functionally characterized. In addition, these mutants have also been deployed for comparative proteome and transcriptome analyses to dissect the molecular networks involved in cereal root formation.
On Optimal 2- and 3-Planar Graphs
2017-06-20

A graph is k-planar if it can be drawn in the plane such that no edge is crossed more than k times. While for k=1, optimal 1-planar graphs, i.e., those with n vertices and exactly 4n-8 edges, have been completely characterized, this has not been the case for k > 1. For k=2,3 and 4, upper bounds on the edge density have been developed for the case of simple graphs by Pach and Tóth, Pach et al. and Ackerman, which have been used to improve the well-known "Crossing Lemma". Recently, we proved that these bounds also apply to non-simple 2- and 3-planar graphs without homotopic parallel edges and self-loops. In this paper, we completely characterize optimal 2- and 3-planar graphs, i.e., those that achieve the aforementioned upper bounds. We prove that they have a remarkably simple regular structure, although they might be non-simple. The new characterization allows us to develop notable insights concerning new inclusion relationships with other graph classes.
ARE SHOAL RESERVOIRS DISCRETE BODIES? A COQUINA SHOAL OUTCROP ANALOGUE FROM THE MID TRIASSIC UPPER MUSCHELKALK, SW GERMANY
2017-06-20

Carbonate ramp reservoirs may show a much higher degree of complexity than the schematic and often layer‐cake type depositional models which are widely used in exploration and reservoir characterisation, especially in three dimensions. This complexity was investigated in an outcrop study of the Ladinian (Middle Triassic) Quaderkalk Formation (Upper Muschelkalk) from SW Germany. The formation was deposited on an epicontinental, gently inclined carbonate ramp in the regressive part of a third‐order depositional sequence and represents a sub‐seismic‐scale coquina‐dominated shoal reservoir analogue. In the study area, coquina carbonates make up a complex system of four stratigraphically separated shoal complexes. The present paper investigates the 1‐D to 3‐D facies distribution, reservoir architecture and sequence stratigraphic evolution of the largest shoal complex of the Quaderkalk Formation, the Oberer Hauptquader. The object of this outcrop analogue study was to improve the understanding of internal reservoir heterogeneities (such as connectivity and continuity) in similar carbonate shoal complexes in the subsurface. To that end, detailed analyses of 71 quarry outcrop and core samples were carried out, together with the study of more than 400 thin sections, the 2‐D analysis of three quarry wall panels and regional‐scale 2‐D correlations, and facies mapping. This investigation documents significant sedimentological heterogeneities at different scales within the studied shoal reservoir analogue. Instead of a continuous facies belt, a number of separate potential reservoirs form a shoal complex “mosaic”. Shoal development is controlled by sequence stratigraphic architecture, mainly by cycles which were responsible for shoal expansion during times of regression (forming potential reservoir‐volume) and shoal drowning during times of transgression (forming seals and potential stratigraphic traps). Within the individual shoal complexes, thickness and lithofacies types show gradational lateral changes. Correspondingly, lithofacies associations within the studied shoal analogue are not defined by sharp boundaries. Thus the present “shoals” do not in fact represent discrete “bodies”, as often depicted in reservoir models and as commonly used in reservoir simulation. In addition, shoal‐internal sedimentological heterogeneities (potential flow baffles in the subsurface) are strongly influenced by a combination of small‐scale cyclicity and event‐type deposition. This study therefore demonstrates the need for sedimentological studies of reservoir heterogeneities at various scales in order to decrease uncertainties and risks in exploration and production.
Determining the drivers of population structure in a highly urbanized landscape to inform conservation planning
2017-06-20

Abstract Understanding the environmental contributors to population structure is of paramount importance for conservation in urbanized environments. We used spatially explicit models to determine genetic population structure under current and future environmental conditions across a highly fragmented, human‐dominated environment in Southern California to assess the effects of natural ecological variation and urbanization. We focused on 7 common species with diverse habitat requirements, home‐range sizes, and dispersal abilities. We quantified the relative roles of potential barriers, including natural environmental characteristics and an anthropogenic barrier created by a major highway, in shaping genetic variation. The ability to predict genetic variation in our models differed among species: 11–81% of intraspecific genetic variation was explained by environmental variables. Although an anthropogenically induced barrier (a major highway) severely restricted gene flow and movement at broad scales for some species, genetic variation seemed to be primarily driven by natural environmental heterogeneity at a local level. Our results show how assessing environmentally associated variation for multiple species under current and future climate conditions can help identify priority regions for maximizing population persistence under environmental change in urbanized regions.
Intuitive Face Judgments Rely on Holistic Eye Movement Pattern
2017-06-20

Non-verbal signals such as facial expressions are of paramount importance for social encounters. Their perception predominantly occurs without conscious awareness and is effortlessly integrated into social interactions. In other words, face perception is intuitive. Contrary to classical intuition tasks, this work investigates intuitive processes in the realm of every-day type social judgments. Two differently instructed groups of participants judged the authenticity of emotional facial expressions, while their eye movements were recorded: an 'intuitive group,' instructed to rely on their "gut feeling" for the authenticity judgments, and a 'deliberative group,' instructed to make their judgments after careful analysis of the face. Pixel-wise statistical maps of the resulting eye movements revealed a differential viewing pattern, wherein the intuitive judgments relied on fewer, longer and more centrally located fixations. These markers have been associated with a global/holistic viewing strategy. The holistic pattern of intuitive face judgments is in line with evidence showing that intuition is related to processing the "gestalt" of an object, rather than focusing on details. Our work thereby provides further evidence that intuitive processes are characterized by holistic perception, in an understudied and real world domain of intuition research.
A Universal Slope Set for 1-Bend Planar Drawings
2017-06-20

We describe a set of Delta-1 slopes that are universal for 1-bend planar drawings of planar graphs of maximum degree Delta>=4; this establishes a new upper bound of Delta-1 on the 1-bend planar slope number. By universal we mean that every planar graph of degree Delta has a planar drawing with at most one bend per edge and such that the slopes of the segments forming the edges belong to the given set of slopes. This improves over previous results in two ways: Firstly, the best previously known upper bound for the 1-bend planar slope number was 3/2(Delta-1) (the known lower bound being 3/4(Delta-1)); secondly, all the known algorithms to construct 1-bend planar drawings with O(Delta) slopes use a different set of slopes for each graph and can have bad angular resolution, while our algorithm uses a universal set of slopes, which also guarantees that the minimum angle between any two edges incident to a vertex is pi/(Delta-1).
The emergence of mesencephalic trigeminal neurons
2017-06-21

Abstract Background The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that influence the dorsal midbrain, the isthmus, which mediates its effects via FGF and WNT signalling and the roof plate, which is a major source of BMP signalling as well as WNT signalling. Methods In this study, we have set out to analyse the importance of FGF, WNT and BMP signalling for the development of the MTN. We have employed pharmacological inhibitors of these pathways in explant cultures as well as utilising the electroporation of inhibitory constructs in vivo in the chick embryo. Results We find that interfering with either FGF or WNT signalling has pronounced effects on MTN development whilst abrogation of BMP signalling has no effect. We show that treatment of explants with either FGF or WNT antagonists results in the generation of fewer MTN neurons and affects MTN axon extension and that inhibition of both these pathways has an additive effect. To complement these studies, we have used in vivo electroporation to inhibit BMP, FGF and WNT signalling within dorsal midbrain cells prior to, and during, their differentiation as MTN neurons. Again, we find that inhibition of BMP signalling has no effect on the development of MTN neurons. We additionally find that cells electroporated with inhibitory constructs for either FGF or WNT signalling can differentiate as MTN neurons suggesting that these pathways are not required cell intrinsically for the emergence of these neurons. Indeed, we also show that explants of dorsal mesencephalon lacking both the isthmus and roof plate can generate MTN neurons. However, we did find that inhibiting FGF or WNT signalling had consequences for MTN differentiation. Conclusions Our results suggest that the emergence of MTN neurons is an intrinsic property of the dorsal mesencephalon of gnathostomes, and that this population undergoes expansion, and maturation, along with the rest of the dorsal midbrain under the influence of FGF and WNT signalling.
Laboratory Intercomparison of Pleistocene Bone Radiocarbon Dating Protocols
2017-06-21

Abstract Since its invention in the late 1940s, radiocarbon ( 14 C) dating has become an important tool for absolute dating. A prerequisite for the acceptance of this method is consistency between, and compatibility of, 14 C dates from different laboratories. To meet these requirements, international laboratory intercomparison studies with different sample materials are frequently performed (e.g. TIRI, FIRI, VIRI and, most recently, SIRI).Intercomparison is especially relevant and difficult for samples close to the dating limit of ~50 kBP, not least for bone samples. A 14 C intercomparison study between the Leibniz-Laboratory in Kiel (Germany), the Center for Isotope Research (CIO) in Groningen (the Netherlands), and the Oxford Radiocarbon Accelerator Unit (ORAU, United Kingdom) was performed on three Pleistocene (MIS3) mammal bone samples from the Brick Quarry site Coenen (BQC) in Germany. The comparison of individually prepared and measured bone collagen 14 C activities, results from shared collagen measurements, and respective background signatures and correction points to the latter as the main factor responsible for observed differences in final given radiocarbon estimates.
Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors
2017-06-21

Glioblastoma (GBM), the most frequent and aggressive malignant primary brain tumor, is characterized by a highly invasive growth. In our previous study we showed that overexpression of Carboxypeptidase E (CPE) mitigated glioma cell migration. In the present study we aimed at deciphering the regulatory mechanisms of the secreted form of CPE (sCPE). By transcriptome analysis and inhibition of signaling pathways involved in the regulation of cell growth and motility, we discovered that overexpression of sCPE was accompanied by differential regulation of mRNAs connected to the motility-associated networks, among others FAK, PAK, Cdc42, integrin, STAT3 as well as TGF-β. Especially SLUG was downregulated in sCPE-overexpressing glioma cells, paralleled by reduced expression of matrix-metalloproteinases (MMP) and, in consequence, by decreased cell migration. Expression of SLUG was regulated by ERK since inhibition of ERK reverted sCPE-mediated SLUG downregulation and enhanced cell motility. In a mouse glioma model, overexpression of sCPE significantly prolonged survival. Our results implicate a novel role for sCPE that mainly affects the expression of motility-associated genes via several signal pathways.
THE GIGAHERTZ AND TERAHERTZ SPECTRUM of MONO-DEUTERATED OXIRANE (c-C2H3DO)
2017-06-21

The rotational spectrum of the chiral mono-deuterated oxirane c-C H DO, an isotopomer of oxirane (ethylenoxide), of which the normal isotopomer has already been detected in interstellar clouds, was measured in the ranges 78 to 108 GHz and 25 to 70 cm . Thus one can expect that c-C H DO will be detectable in space in the future given the current accurate laboratory data.c-C H DO is also of interest as a simple prototypical molecule for isotopic chirality and parity violation.footnote{M. Quack, textit{Angew. Chem. Int. Ed.} textbf{28}, 571-586 (1989).} footnote{M. Quack , textit{Fundamental Symmetries and Symmetry Violations from High-resolution Spectroscopy}, textit{Handbook of High Resolution Spectroscopy, M. Quack and F. Merkt eds.},John Wiley &amp; Sons Ltd, Chichester, New York, 2001, vol. 1, ch. 18, pp. 659-722.} footnote{R. Berger, G. Laubender, M. Quack, A. Sieben, J. Stohner and M. Willeke, textit{Angew. Chem. Int. Ed.} textbf{44}, 3623-3626 (2005).} footnote {S. Albert, I. Bolotova, Z. Chen, C. F'{a}bri, L. Horn'{y}, M. Quack, G. Seyfang and D. Zindel, textit{Phys.Chem.Chem.Phys.}textbf{18}, 21976-21993 (2016).} The Zurich GHz spectrometer and a high resolution FTIR interferometer using synchrotron radiation was used for the THz spectrum.$^{d} _{'} _{'}$footnote {S. Albert, F. Arn, I. Bolotova, Z. Chen, C. F'{a}bri, G. Grassi, Ph. Lerch, M. Quack, G. Seyfang, A. Wokaun and D. Zindel, textit{J.Phys.Chem.Lett},textbf{7}, 3847-3853 (2016).} Previous laboratory work on the rotational spectrum of deuterated oxirane extended only to the frequency of 45 GHz. A total of 119 transitions have been newly assigned in the GHz range (extended to 119 GHz) up to J=18 and 900 transitions in the THz region at most to J=70. The analyses of the rotational spectra shall be discussed in detail in relation to their astrophysical importance.