julilili42/papers huggingface dataset:
How to encourage people to build diverse business networks?
2019-08-27

With professional social networking sites (PSNS) networking opportunities basically have no limits. Industry experts, influencers, and knowledgeable people from all sorts of fields and from all over the world can potentially become part of your business network, providing access to new perspectives and new information. Connecting with a diverse set of people with different expertise and knowledge can enhance personal work performance and career advancement. Yet, many people are online mainly connected with others they know from their direct work environment. Despite a lot of research concerning the influences on networking behavior, there is no research investigating if people who know that networking can be beneficial network more. More importantly, there is no research investigating if people who know that a diverse network is important network more diversely and whether or not affective and technical influences interfere with the relationship between knowing and doing. In an experimental study (n = 316), we examine the effects of knowledge and website functionalities on professional networking in order to draw implications on how to improve PSNS to encourage people to build diverse business networks. We find that people who generally know that networking is beneficial, in fact, network more. Moreover, people who know that diversity is important network more diversely. Besides, technical features of the website (e.g. who is recommended) can influence people's networking behavior. Finally, results are discussed and implications to improve PSNS are drawn.
Investigation of novel biomarkers of drug-induced kidney injury in renal transplant recipients undergoing graft biopsy
2019-08-27

Abstract Urinary and blood kidney biomarkers (BM) remain insufficient to detect early kidney injury. Our aim was to compare new kidney BM with histopathological data in kidney allograft recipients. Blood and urine samples of consecutive adult patients were collected just prior graft biopsy. All kidney samples were classified according to Banff 2007. The diagnostic performance (area under ROC curve, AUROC) of 16 new BM was compared to those of urinary proteins, blood urea nitrogen, eGFR and serum creatinine to identify histopathological groups. 223 patients were analyzed. Versus slightly modified renal parenchyma (SMRP), microalbuminuria and urinary proteins had the highest diagnostic performance toward glomerular injury. Urinary neutrophil gelatinase associated lipocalin (NGAL) had the best performance values for acute tubular necrosis (ATN) versus SMRP (AUROC 0.93). Others BM reached slightly lower AUROC reaching 0.89. When comparing ATN to acute rejection several new urinary BM (NGAL, cystatin C, and MCP1) and classical BM (eGFR, serum creatinine) reached similar AUROC values ranging from 0.80 to 0.85. Values of urinary NGAL were 10-fold higher in ATN compared to acute rejection (p = 0.0004). New BM did not outperform classical BM during renal transplantation. Urinary NGAL might be helpful to discriminate ATN and acute rejection.
What is learned in approach-avoidance tasks? On the scope and generalizability of approach-avoidance effects
2019-08-27

Previous research has shown that approaching a stimulus makes it more positive, while avoiding a stimulus makes it more negative. The present research demonstrates that approach-avoidance behaviors have the potential to charge stimulus attributes such as color with evaluative meaning. This evaluation carries over to other stimuli with that feature. We address the latter point by assessing the influence of colors that were approached or avoided on the perceived attractiveness of persons wearing those colors. We show that wearing a certain color makes people appear more attractive when this color is associated with approach rather than avoidance. In line with a self-perception account of these effects, we obtained approach-avoidance effects on stimulus attributes only when participants carried out approach-avoidance behaviors towards these colors or imagined doing so. This set of experiments adds to the evaluative learning literature by demonstrating approach-avoidance effects on stimulus attributes and that these effects carry over to new classes of stimuli and new tasks. Moreover, we systematically investigated boundary conditions for these effects. Finally, with this research we introduce an ontogenetic perspective to research into colors and their influence on psychological functioning.
Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis
2019-08-28

This phase 3 trial compared tandem autologous stem cell transplantation (autoSCT) versus autoSCT followed by reduced-intensity conditioning allogeneic stem cell transplantation (auto/alloSCT) in patients with newly diagnosed multiple myeloma (MM) with deletion of (del) chromosome 13q (del13q). The availability/absence of a human leukocyte antigen-matched-related or matched-unrelated donor (MUD) determined the nature of the second SCT. The primary endpoint was progression-free survival (PFS) in the intention-to-treat population (n = 199). Auto/alloSCT was performed in 126 patients; 74 received MUD allografts. After 91 months median follow-up, median PFS with auto/allo versus tandem autoSCT was 34.5 versus 21.8 months (P = 0.003; adjusted hazard ratio 0.55, 95% confidence interval 0.36-0.84). Median overall survival (OS) was 70.2 versus 71.8 months (P = 0.856). Two-year non-relapse mortality with auto/allo versus tandem autoSCT was 14.3% versus 4.1% (P = 0.008). In patients harboring both del13q and del17p, median PFS and OS were 37.5 and 61.5 months with auto/allo (n = 19) versus 6.1 and 23.4 months with tandem autoSCT (n = 6) (P = 0.0002 and 0.032). Our findings suggest that auto/alloSCT significantly extends PFS versus tandem autoSCT in del13q MM, and indicate some survival benefit for first-line alloSCT in high-risk MM.
Plant Kinesin-12: Localization Heterogeneity and Functional Implications
2019-08-28

Kinesin-12 family members are characterized by an N-terminal motor domain and the extensive presence of coiled-coil domains. Animal orthologs display microtubule plus-end directed motility, bundling of parallel and antiparallel microtubules, plus-end stabilization, and they play a crucial role in spindle assembly. In plants, kinesin-12 members mediate a number of developmental processes including male gametophyte, embryo, seedling, and seed development. At the cellular level, they participate in critical events during cell division. Several kinesin-12 members localize to the phragmoplast midzone, interact with isoforms of the conserved microtubule cross-linker MICROTUBULE-ASSOCIATED PROTEIN 65 (MAP65) family, and are required for phragmoplast stability and expansion, as well as for proper cell plate development. Throughout cell division, a subset of kinesin-12 reside, in addition or exclusively, at the cortical division zone and mediate the accurate guidance of the phragmoplast. This review aims to summarize the current knowledge on kinesin-12 in plants and shed some light onto the heterogeneous localization and domain architecture, which potentially conceals functional diversification.
Auditory Space Perception in the Blind: Horizontal Sound Localization in Acoustically Simple and Complex Situations
2019-08-28

Even though it is widely believed that cross-modal neuroplasticity in blindness results in enhanced auditory spatial abilities, a growing number of studies also indicate disadvantages of blind persons for specific, more demanding audiospatial tasks. Here, the effects of blindness on horizontal sound localization were compared for simple localization of target sounds presented in isolation and target localization in an acoustically complex ( cocktail-party) situation with multiple distractor sounds. While performances of blind and sighted subjects were similar in the cocktail-party setting, a significant disadvantage of blind subjects was found for simple localization of sound sources presented in the center of the frontal space, with the mean absolute error being more than twice that of controls for targets in the median plane. The latter result could be due to the lack of visual calibration of auditory space, which may, in sighted persons, be most effective in the region of maximum visual acuity. On the other hand, the normal performance of blind persons in cocktail-party localization could be explained by the fact that this task, in addition to genuine spatial analysis, critically involved spectrotemporal analysis of the auditory scene to separate different sources for which superior performance is known from previous research.
Parallel channels for motion feature extraction in the pretectum and tectum of larval zebrafish
2019-08-28

Abstract Non-cortical visual areas in vertebrate brains extract different stimulus features, such as motion, object size and location, to support behavioural tasks. The optic tectum and pretectum, two primary visual areas, are thought to fulfil complementary biological functions in zebrafish to support prey capture and optomotor stabilisation behaviour. However, the adaptations of these brain areas to behaviourally relevant stimulus statistics are unknown. Here, we used calcium imaging to characterize the receptive fields of 1,926 motion-sensitive neurons in diencephalon and midbrain. We show that many caudal pretectal neurons have large receptive fields (RFs), whereas RFs of tectal neurons are smaller and mostly size-selective. RF centres of large-size RF neurons in the pretectum are predominantly located in the lower visual field, while tectal neurons sample the upper-nasal visual field more densely. This tectal visual field sampling matches the expected prey item locations, suggesting that the tectal magnification of the upper-nasal visual field might be an adaptation to hunting behaviour. Finally, we probed optomotor responsiveness and found that even relatively small stimuli drive optomotor swimming, if presented in the lower-temporal visual field, suggesting that the pretectum preferably samples information from this region on the ground to inform optomotor behaviour. Our characterization of the parallel processing channels for non-cortical motion feature extraction provides a basis for further investigation into the sensorimotor transformations of the zebrafish brain and its adaptations to habitat and lifestyle.
Front Cover: Dehydrative Coupling of Benzylic Alcohols Catalyzed by Brønsted Acid/Lewis Base (Eur. J. Org. Chem. 34/2019)
2019-08-28

The Front Cover shows the process of the dehydrogenative coupling of 1-phenylethanol catalyzed by a Brønsted acid depicted as scissors. The scissors cut off water from the benzylic alcohol to form benzylic carbocations (yellow jigsaw pieces) and vinylarenes (orange jigsaw pieces), which can be attached to each other to form a cationic dimeric species. Further orange jigsaw pieces could now be added quite easily, forming oligomeric species. This is inhibited by the presence of triphenylphosphine (blue jigsaw piece) in catalytic amounts, leading to the desired dimeric alkene. More information can be found in the Communication by I. Fleischer et al.
Human Leucocyte Antigen Sensitisation and Its Impact on Transfusion Practice
2019-08-29

Human leucocyte antigen (HLA) sensitisation, including the formation of antibodies against HLA, can cause serious effects in patients receiving blood. Under certain circumstances, donor HLA antibodies in the blood product can trigger the patient’s granulocytes to release mediators that cause transfusion-associated lung injury (TRALI), a serious complication of transfusion. The HLA systems of both donor and patient are involved in transfusion-associated graft-versus-host disease, which is a rare disease with a high mortality. Patient HLA antibodies can destroy incompatible platelets and may cause refractoriness to platelet transfusion. Identification of a patient’s HLA antibody specificities is necessary for issuing compatible platelets to overcome refractoriness. Many techniques for the detection and identification of HLA antibodies have been developed, including complement-dependent cytotoxicity assay, bead-based assays, the platelet adhesion immunofluorescence test, and the monoclonal antibody-specific immobilisation of platelet antigens assay. Different strategies for the selection of HLA-compatible platelets are applied. These strategies depend on the breadth of antibody reactivity and range from avoiding single HLA antigens in the platelet concentrates issued to apheresis of platelets from HLA-identical donors. The mechanisms of HLA sensitisation and the efforts made to provide compatible blood products to sensitised patients are reviewed in this article from the perspective of clinical transfusion medicine.
First identification and quantification of detached-tip vortices behind a wind energy converter using fixed-wing unmanned aircraft system
2019-08-29

Abstract. In the present study, blade-tip vortices have been experimentally identified in the wake of a commercial wind turbine using the Multi-purpose Airborne Sensor Carrier Mark 3 (MASC Mk 3) unmanned aircraft system (UAS) of the University of Tübingen. By evaluation of the wind components, detached blade-tip vortices were identified in the time series. From these measurements, the circulation and core radius of a pair of detached blade-tip vortices is calculated using the Burnham–Hallock (BH) wake vortex model. The presented data were captured under a dominating marine stratification about 2km from the North Sea coastline with northern wind direction. The measured vortices are also compared to the analytical solution of the BH model for two vortices spinning in opposite directions. The model has its origin in aviation, where it describes two aircraft wake vortices spinning in opposite directions. An evaluation method is presented to measure detached-tip vortices with a fixed-wing UAS. The BH model will be used to describe wake vortex properties behind a wind energy converter (WEC). The circulation and core radius of detached blade-tip vortices will be calculated. Also a proposition of the model for WEC wake evaluations will be made to describe two independent co-rotating vortices. Quantifying blade-tip vortices helps to understand the process of vortices detaching from a rotor blade of a wind turbine, their development in the wake until finally dissipating in the far wake and contributing to overall atmospheric turbulence. This is especially interesting for set-ups of numerical simulations when setting the spatial resolution of the simulation grid.
Equity versus Efficiency? Evidence from Three - Person Generosity Experiments
2019-08-29

In two-person generosity games, the proposer’s agreement payoff is exogenously given, whereas that of the responder is endogenously determined by the proposer’s choice of the pie size. In three-person generosity games, equal agreement payoffs for two of the players are either exogenously excluded or imposed. We predict that the latter crowds out - or at least weakens - efficiency seeking. Our treatments rely on a 2x3 factorial design, differing in whether the responder or the third (dummy) player is the residual claimant and whether the proposer’s agreement payoff is larger, equal, or smaller than the other exogenously given agreement payoff.
Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
2019-08-29

Abstract The transport and Golgi organization 1 (TANGO1) family proteins have been shown to play pivotal roles in the secretory pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic reticulum exit sites (ERES), where it binds bulky cargo within the ER lumen and recruits membranes from the ER Golgi intermediate compartment (ERGIC) to create an exit route for their export. Tango1 knockout mice display a global collagen secretion defect and perinatal lethality. Here we report the first TANGO1-associated syndrome in humans, which mainly manifests in a collagenopathy. A synonymous substitution that results in exon 8 skipping in most mRNA molecules, ultimately leading to a truncated TANGO1 protein was identified as the disease-causing mutation. The four homozygously affected sons of a consanguineous family display severe dentinogenesis imperfecta, short stature, various skeletal abnormalities, insulin-dependent diabetes mellitus, sensorineural hearing loss, and mild intellectual disability. Functional studies in HeLa and U2OS cells revealed that the corresponding truncated TANGO1 protein is dispersed in the ER and its expression in cells with intact endogenous TANGO1 impairs cellular collagen I secretion.
»Gender, Class, Race Matter.«
2019-08-29

Abstract »Gender, Class, Race Matter.« How Social Differences/Categories Structure Biographies. A Case Study Biographies are structured by norms, conventions and social categories such as class, gender or race. This article is about the relationship between biographies, social structures and norms. It describes the constitution of differences and subjects and discusses the possibility of resistance against the limitation by norms. Since norms are incorporated and naturalised this is a difficult request. That is illustrated by the novel »The End of Eddy« by Édouard Louis.
Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients
2019-08-30

Abstract Aims Clopidogrel is prescribed for the prevention of atherothrombotic events. While investigations have identified genetic determinants of inter-individual variability in on-treatment platelet inhibition (e.g. CYP2C19*2), evidence that these variants have clinical utility to predict major adverse cardiovascular events (CVEs) remains controversial. Methods and results We assessed the impact of 31 candidate gene polymorphisms on adenosine diphosphate (ADP)-stimulated platelet reactivity in 3391 clopidogrel-treated coronary artery disease patients of the International Clopidogrel Pharmacogenomics Consortium (ICPC). The influence of these polymorphisms on CVEs was tested in 2134 ICPC patients (N = 129 events) in whom clinical event data were available. Several variants were associated with on-treatment ADP-stimulated platelet reactivity (CYP2C19*2, P = 8.8 × 10−54; CES1 G143E, P = 1.3 × 10−16; CYP2C19*17, P = 9.5 × 10−10; CYP2B6 1294 + 53 C &amp;gt; T, P = 3.0 × 10−4; CYP2B6 516 G &amp;gt; T, P = 1.0 × 10−3; CYP2C9*2, P = 1.2 × 10−3; and CYP2C9*3, P = 1.5 × 10−3). While no individual variant was associated with CVEs, generation of a pharmacogenomic polygenic response score (PgxRS) revealed that patients who carried a greater number of alleles that associated with increased on-treatment platelet reactivity were more likely to experience CVEs (β = 0.17, SE 0.06, P = 0.01) and cardiovascular-related death (β = 0.43, SE 0.16, P = 0.007). Patients who carried eight or more risk alleles were significantly more likely to experience CVEs [odds ratio (OR) = 1.78, 95% confidence interval (CI) 1.14–2.76, P = 0.01] and cardiovascular death (OR = 4.39, 95% CI 1.35–14.27, P = 0.01) compared to patients who carried six or fewer of these alleles. Conclusion Several polymorphisms impact clopidogrel response and PgxRS is a predictor of cardiovascular outcomes. Additional investigations that identify novel determinants of clopidogrel response and validating polygenic models may facilitate future precision medicine strategies.
Refugee Camp Monitoring and Environmental Change Assessment of Kutupalong, Bangladesh, Based on Radar Imagery of Sentinel-1 and ALOS-2
2019-08-30

Approximately one million refugees of the Rohingya minority population in Myanmar crossed the border to Bangladesh on 25 August 2017, seeking shelter from systematic oppression and persecution. This led to a dramatic expansion of the Kutupalong refugee camp within a couple of months and a decrease of vegetation in the surrounding forests. As many humanitarian organizations demand frameworks for camp monitoring and environmental impact analysis, this study suggests a workflow based on spaceborne radar imagery to measure the expansion of settlements and the decrease of forests. Eleven image pairs of Sentinel-1 and ALOS-2, as well as a digital elevation model, were used for a supervised land cover classification. These were trained on automatically-derived reference areas retrieved from multispectral images to reduce required user input and increase transferability. Results show an overall decrease of vegetation of 1500 hectares, of which 20% were used to expand the camp and 80% were deforested, which matches findings from other studies of this case. The time-series analysis reduced the impact of seasonal variations on the results, and accuracies between 88% and 95% were achieved. The most important input variables for the classification were vegetation indices based on synthetic aperture radar (SAR) backscatter intensity, but topographic parameters also played a role.
Function, Regulation and Biological Roles of PI3Kγ Variants
2019-08-30

Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kγ occur as two different heterodimeric variants: PI3Kγ (p87) and PI3Kγ (p101), which share the same p110γ catalytic subunit but differ in their associated non-catalytic subunit. Here we concentrate on specific PI3Kγ features including its regulation and biological functions. In particular, the roles of its non-catalytic subunits serving as the main regulators determining specificity of class IB PI3Kγ enzymes are highlighted.
Triphasic Pulses in Cochlear Implant Patients With Facial Nerve Stimulation
2019-08-30

Objective: Evaluation of triphasic pulse stimulation in comparison to the traditional biphasic pulse stimulation in cochlear implant (CI) patients with unintended facial nerve costimulation. Study Design: Retrospective case review. Setting: Cochlear Implant Center of a University Department of Otolaryngology, Head and Neck Surgery. Patients: Fifteen CI patients (MED-EL, Innsbruck, Austria) received a triphasic fitting map instead of a biphasic fitting map due to a previous diagnosis of facial nerve stimulation or stimulus induced pain during the years 2014 to 2017. Intervention(s): Application of a triphasic stimulation strategy. Main Outcome Measure(s): Reduction of facial nerve costimulation and speech understanding. Biphasic and triphasic fitting maps were compared to accurately assess the effects of the switch, and hearing tests (monosyllables and sentences in noise tests) were analyzed. Results: Triphasic pulse stimulation showed a significant reduction of unintended side effects and resulted in an observed improved quality of life in most cases. Although there was no significant change in the understanding of speech with CI in all test situations, in many cases, improvement was observed. Conclusions: Triphasic pulse stimulation had a beneficial effect for CI patients with severe, unintended costimulation and should be considered a valuable tool during CI fitting.
Measurement of media pedagogical competences of adult educators
2019-08-30

Media pedagogical competence is critical for the modern-day adult educator. In the process of adult learning, both the use of digital media in the classroom and the transfer of knowledge in dealing with media are the basis for social participation and individual development that must be provided by teachers. However, at present little or no research has been conducted that assess media pedagogical competence of adult educators. Moreover, an instrument to measure media pedagogical competence was lacking. In order to redress these concerns, in the present paper an instrument for objectively measuring media pedagogical competence is designed and piloted with adult educators (n=622). The study provides the first results concerning objective measurement of adult educator media pedagogical competence.