julilili42/papers huggingface dataset:
The Securitisation of Climate Change
2016-04-28

This book provides the first systematic comparative analysis of climate security discourses. It analyses the securitisation of climate change in four different countries: USA, Germany, Turkey, and Mexico. The empirical analysis traces how specific climate-security discourses have become dominant, which actors have driven this process, what political consequences this has had and what role the broader context has played in enabling these specific securitisations. In doing so, the book outlines a new and systematic theoretical framework that distinguishes between different referent objects of securitisation (territorial, individual and planetary) and between a security and risk dimension. It thereby clarifies the ever-increasing literature on different forms of securitisation and the relationship between security, risk and politics. Whereas securitisation studies have traditionally focused on either a single country case study or a global overview, consequently failing to reconstruct detailed securitisation dynamics, this is the first book to provide a systematic comparative analysis of climate security discourses in four countries and thus closes an empirical gap in the present literature. In addition, this comparative framework allows the drawing of conclusions about the conditions for and consequences of successful securitisation based on empirical and comparative analysis rather than theoretical debate only. This book will of interest to students of climate change, environmental studies, critical security, global governance, and IR in general.
Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
2016-04-28

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 and BACHD models of HD. Using diffusion tensor magnetic resonance imaging (DT-MRI), we demonstrate that microstructural WM abnormalities occur from an early age in YAC128 mice. Similarly, electron microscopy analysis of myelinated fibres of the corpus callosum indicated that myelin sheaths are thinner in YAC128 mice as early as 1.5 months of age, well before any neuronal loss can be detected. Transcript levels of myelin-related genes in striatal and cortical tissues were significantly lower in YAC128 mice from 2 weeks of age, and these findings were replicated in differentiated primary oligodendrocytes from YAC128 mice, suggesting a possible mechanistic explanation for the observed structural deficits. Concordant with these observations, we demonstrate reduced expression of myelin-related genes at 3 months of age and WM microstructural abnormalities using DT-MRI at 12 months of age in the BACHD rats. These findings indicate that WM deficits in HD are an early phenotype associated with cell-intrinsic effects of mutant huntingtin on myelin-related transcripts in oligodendrocytes, and raise the possibility that WM abnormalities may be an early contributing factor to the pathogenesis of HD.
Elemental mapping of Neuromelanin organelles of human Substantia Nigra: correlative ultrastructural and chemical analysis by analytical transmission electron microscopy and nano‐secondary ion mass spectrometry
2016-04-28

Abstract Neuromelanin (NM) is a compound which highly accumulates mainly in catecholamine neurons of the substantia nigra (SN), and is contained in organelles (NM‐containing organelles) with lipid bodies and proteins. These neurons selectively degenerate in Parkinson's disease and NM can play either a protective or toxic role. NM‐containing organelles of SN were investigated by Analytical Electron Microscopy (AEM) and Nano‐Secondary Ion Mass Spectrometry (NanoSIMS) within human tissue sections with respect to ultrastructure and elemental composition. Within the NM‐containing organelle, the single NM granules and lipid bodies had sizes of about 200–600 nm. Energy‐Dispersive X‐ray microanalysis spectra of the NM granules and lipid bodies were acquired with 100 nm beam diameter in AEM, NanoSIMS yielded elemental maps with a lateral resolution of about 150 nm. AEM yielded the quantitative elemental composition of NM granules and bound metals, e.g., iron with a mole fraction of about 0.15 atomic percent. Chemical analyses by AEM and NanoSIMS were consistent at the subcellular level so that nanoSIMS measurements have been quantitated. In NM granules of SN from healthy subjects, a significant amount of S, Fe, and Cu was found. In lipid bodies an amount of P consistent with the presence of phospholipids was measured. The improved detection limits of nanoSIMS offer new possibilities for chemical mapping, high‐sensitivity trace element detection, and reduced acquisition times. Variations between individual NM granules can now be investigated effectively and quantitatively by NanoSIMS mapping Cu and Fe. This should yield new insight into the changes in chemical composition of NM pigments during healthy aging and disease. image Neuromelanin‐containing organelles of dopamine neurons in normal human substantia nigra were investigated by analytical electron mircoscopy and secondary ion mass spectroscopy (NanoSIMS) yielding the ultrastructure and elemental composition. In neuromelanin granules a significant amount of S, Fe and Cu was found. In lipid bodies an amount of P consistent with the presence of phospholipids was measured. The improved sensitivity of NanoSIMS shows differences in chemical composition between individual neuromelanin granules and allows to study chemical changes of neuromelanin organelles during aging and disease.
Compact objects in Horndeski gravity
2016-04-28

Horndeski gravity holds a special position as the most general extension of Einstein’s theory of general relativity (GR) with a single scalar degree of freedom and second-order field equations. Because of these features, Horndeski gravity is an attractive phenomenological playground to investigate the consequences of modifications of GR in cosmology and astrophysics. We present a review of the progress made so far in the study of compact objects (black holes (BHs) and neutron stars (NSs)) within Horndeski gravity. In particular, we review our recent work on slowly rotating BHs and present some new results on slowly rotating NSs.
Negative Mood Increases Selective Attention to Negatively Valenced Body Parts in Female Adolescents with Anorexia Nervosa
2016-04-28

The results emphasize the role of negative mood in the maintenance of pathological information processing of the self-body. This increased body-related negativity-bias during negative mood may lead to the persistence and aggravation of AN patients' body image disturbance.
A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation
2016-04-28

In newly diagnosed multiple myeloma (MM), patients ineligible for front-line autologous stem cell transplantation (ASCT), melphalan and prednisone (MP) with thalidomide (MPT) or bortezomib (VMP) are standard first-line therapeutic options. Despite new treatment regimens incorporating bortezomib or lenalidomide, MM remains incurable. The FIRST study demonstrated significant improvement in progression-free survival (PFS) and overall survival (OS) for the combination of lenalidomide and low-dose dexamethasone (Rd) until progression vs. MPT in transplant-ineligible ndMM patients. However, to date no head-to-head randomized controlled trials (RCTs) have compared Rd or MPT versus VMP. We conducted a network meta-analysis using RCTs identified through a systematic literature review to evaluate the relative efficacy of Rd versus other regimens on survival endpoints in previously untreated MM patients ineligible for ASCT. In this analysis, Rd was associated with a significant PFS and survival advantage versus other first-line treatments (VMP, MPT, MP), challenging the role of alkylators in this setting.
Influence of the reduction of urban lawn mowing on wild bee diversity (Hymenoptera, Apoidea)
2016-04-28

To analyse the effects of reduced green space management in urban areas on the biodiversity of insects, we compared intensely mowed lawns (mowed 12 times per year) with meadows under reduced maintenance (mowed only twice per year) in the city of Tubingen (Baden-Wurttemberg, Germany). Over the entire field season, 177 wild bee individuals representing 43 species were caught using sweep nets. Areas with reduced maintenance showed significantly higher total species numbers and biodiversity indices. Our research supports the initiative “Bunte Wiese (Colourful Meadow) - Species Diversity in Public Greenspaces” of the University of Tubingen, which is campaigning for the enhancement of species diversity in public urban greenland areas by reorganising intensive mowing into a “twice a year” programme.
Dancing with the SNARC: Measuring spatial-numerical associations on a digital dance mat.
2016-04-28

According to the concept of embodied numerosity, bodily experiences influence the way in which we process numerical magnitude. The development of this influence could be anchored in the spatial ordering of numbers along a mental number line representation, which is measured by effects of spatial-numerical associations. The aim of this study was to investigate whether horizontally oriented full-body movement and visual presentation of a number line both contribute to spatial-numerical associations in children. We presented fourth-graders with 2 magnitude comparison tasks that differed in the relevance of magnitude information. In both tasks, we varied the amount of bodily movement in different response conditions (responding verbally, with a foot tap, or by jumping) and the visual presentation (items were presented with or without a number line). From the data, we calculated 2 spatial-numerical effects and expected to find the strongest effects if a full-body response was combined with a number line presentation. The 2 effects were differentially influenced by response modalities, but not presentation. The SNARC (= Spatial Numerical Association of Response Codes) effect was present in all conditions and was not influenced by our manipulations. In contrast, a new relative numerical congruity effect was influenced by the variations in responses in accordance with our hypotheses. The relative numerical congruity effect results suggest that responses involving bodily movement increase activation of spatial-numerical associations compared to verbal responses. These results are the first to demonstrate such an influence in a full-body approach in elementary schoolchildren. (PsycINFO Database Record
Accurate prediction of hard-sphere virial coefficients B6 to B12 from a compressibility-based equation of state
2016-04-28

We derive an analytical equation of state for the hard-sphere fluid that is within 0.01% of computer simulations for the whole range of the stable fluid phase. In contrast, the commonly used Carnahan-Starling equation of state deviates by up to 0.3% from simulations. The derivation uses the functional form of the isothermal compressibility from the Percus-Yevick closure of the Ornstein-Zernike relation as a starting point. Two additional degrees of freedom are introduced, which are constrained by requiring the equation of state to (i) recover the exact fourth virial coefficient B4 and (ii) involve only integer coefficients on the level of the ideal gas, while providing best possible agreement with the numerical result for B5. Virial coefficients B6 to B10 obtained from the equation of state are within 0.5% of numerical computations, and coefficients B11 and B12 are within the error of numerical results. We conjecture that even higher virial coefficients are reliably predicted.
Subcortical source and modulation of the narrowband gamma oscillation in mouse visual cortex
2016-04-28

Summary Primary visual cortex (V1) exhibits two types of gamma rhythm: broadband activity in the 30–90 Hz range, and a narrowband oscillation seen in mice at frequencies close to 60 Hz. We investigated the sources of the narrowband gamma oscillation, the factors modulating its strength, and its relationship to broadband gamma activity. Narrowband and broadband gamma power were uncorrelated. Increasing visual contrast had opposite effects on the two rhythms: it increased broadband activity, but suppressed the narrowband oscillation. The narrowband oscillation was strongest in layer 4, and was mediated primarily by excitatory currents entrained by the synchronous, rhythmic firing of neurons in the lateral geniculate nucleus (LGN). The power and peak frequency of the narrowband gamma oscillation increased with light intensity. Silencing the cortex optogenetically did not affect narrowband oscillation in either LGN firing or cortical excitatory currents, suggesting that this oscillation reflects unidirectional flow of signals from thalamus to cortex. Highlights •Local field potential in mouse primary visual cortex exhibits a pronounced narrowband gamma oscillation close to 60 Hz. •Narrowband gamma is highest in the thalamorecipient layer 4 •Narrowband gamma increases with light intensity and arousal state, and is suppressed by visual contrast. •Lateral geniculate nucleus neurons fire synchronously at the narrowband gamma frequency, independent of V1 activity.
The Concept of Action and the Relevance of Intentional Collective Action in History
2016-04-28

The article starts with the theses that it is the very concept of action that is at stake in many debates between philosophers and historians. Whereas in philosophy actions are conceptualized by reference to their beginning, namely their motives or intentions, in historiography the consequences of actions are much more in the focus of interest. Especially the debate about the dualism of structure and agency is characterized by different concepts of action. In the article it is argued that this dualism can be overcome by stressing the intentionality of collective actions. First, a concept of action is developed against the background of a theory of intentionality. Second, intentional collective action is distinguished from individual and social actions and an analysis of a collective we-intention is proposed. Third, it is argued that the development of social structures has to be understood by reference to intentional collective actions.
Is problematic mobile phone use explained by chronotype and personality?
2016-04-29

In this study, the relationships among problematic mobile phone use, age, gender, personality and chronotype of Turkish university students were examined. The study included 902 university students (73% female, 27% male) and their participation in the study was anonymous and voluntary. Data were collected from each participant by assessing a demographic questionnaire, Composite Scale of Morningness (CSM) as a measure of chronotype, the Big Five Inventory (BIG-5) for personality assessment and Mobile Phone Problem Usage Scale (MPPUS). The most important result was that CSM scores were the best predictor for problematic mobile phone usage, and as a consequence, evening-oriented university students scored higher on the MPPUS. This result remained, even when compared with the most influential personality predictor, conscientiousness. In addition, while extraversion positively predicted, emotional stable and chronotype negatively predicted problematic mobile phone use. Lastly, age and gender were not predictors of problematic mobile phone use.
Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome
2016-04-29

Alcohol dependence is a severe disorder contributing substantially to the global burden of disease. Despite the detrimental consequences of chronic alcohol abuse and dependence, effective prevention strategies as well as treatment options are largely missing to date. Accumulating evidence suggests that gene-environment interactions, including epigenetic mechanisms, play a role in the etiology of alcohol dependence. A recent epigenome-wide study reported widespread alterations of DNA methylation patterns in alcohol dependent patients compared to control individuals. In the present study, we validate and replicate one of the top findings from this previous investigation in an independent cohort: the hypomethylation of GDAP1 in patients. To our knowledge, this is the first independent replication of an epigenome-wide finding in alcohol dependence. Furthermore, the AUDIT as well as the GSI score were negatively associated with GDAP1 methylation and we found a trend toward a negative association between GDAP1 methylation and the years of alcohol dependency, pointing toward a potential role of GDAP1 hypomethylation as biomarker for disease severity. In addition, we show that the hypomethylation of GDAP1 in patients reverses during a short-term alcohol treatment program, suggesting that GDAP1 DNA methylation could also serve as a potential biomarker for treatment outcome. Our data add to the growing body of knowledge on epigenetic effects in alcohol dependence and support GDAP1 as a novel candidate gene implicated in this disorder. As the role of GDAP1 in alcohol dependence is unknown, this novel candidate gene should be followed up in future studies.
Safety of transesophageal echocardiography during extracorporeal life support
2016-04-29

Introduction: Use of extracorporeal life support (ECLS) has significantly increased in critically ill patients refractory to medical management. ECLS requires systemic anticoagulation to avoid thromboembolic complications and superimposed coagulopathies are common. Transesophageal echocardiography (TEE) is frequently employed to assess cannula position and cardiac function during extracorporeal therapy. The goal of this study was to assess whether TEE probe insertion and removal in systemically anticoagulated ECLS patients was safe compared to patients without ECLS and normal coagulation studies. Methods: Eighty-seven separate TEE examinations in 53 adult ECLS patients were analyzed. Detailed complication profiles were logged for each patient from initiation through discontinuation of ECLS. Routine coagulation testing was recorded within two hours prior to the TEE exams. Controls consisted of age- and gender-matched patients undergoing perioperative TEE without ECLS and normal coagulation (N=87). Results: Overall TEE-associated morbidity in ECLS patients was 2.3% and consisted of minor oropharyngeal bleeding (2/87 TEE exams) exclusively. The patients presenting with oropharyngeal bleeding received heparin for anticoagulation and had two or more abnormal coagulation studies at the time of TEE. Seventy-nine percent of ECLS patients received intravenous heparin infusions, 6.8% argatroban and 3.4% epoprostenol. Ten-point-eight percent of patients were not anticoagulated at the time of TEE because of pre-existing bleeding complications and/or deranged plasmatic coagulation profiles. No major complications (e.g., esophageal perforation, gastrointestinal bleeding, accidental extubation) were recorded in either group. Conclusions: TEE remained safe in critically ill patients under ECLS, despite systemic anticoagulation, during probe insertion, manipulation and removal. TEE-related complications pertained solely to oropharyngeal bleeding amenable to conservative management.
Origin of modern syphilis and emergence of a contemporary pandemic cluster
2016-04-29

Abstract Syphilis swept across the world in the 16th century as one of most prominent documented pandemics and is re-emerging worldwide despite the availability of effective antibiotics. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the non-cultivable and clonal nature of the causative bacterium Treponema pallidum subsp. pallidum . In this study, we used DNA capture and next generation sequencing to obtain whole genome data from syphilis patient specimens and from treponemes propagated in laboratory settings. Phylogenetic analyses indicate that the syphilis strains examined here share a common ancestor after the 15th century. Moreover, most contemporary strains are azithromycin resistant and members of a globally dominant cluster named here as SS14-Ω. This cluster diversified from a common ancestor in the mid-20 th century and has the population genetic and epidemiological features indicative of the emergence of a pandemic strain cluster.
Resistance to renal denervation therapy — Identification of underlying mechanisms by analysis of differential DNA methylation
2016-04-29

The present study describes novel molecular targets potentially contributing to reduction of blood pressure after RDN in some patients. Identifying patients with a high responsiveness to RDN could contribute to an individualized therapy in drug resistant hypertension.
Supplementary Material Accompanying "Factoring Lexical And Phonetic Phylogenetic Characters From Word Lists"
2016-04-29

This repository contains the scripts and the data that were used to run the analyses for the paper "Factoring lexical and phonetic phylogenetic characters from word lists". For details, please refer to the README.md file provided along with the dataset. If you run into problems replicating the analysis, please do not hesitate to contact the authors.
Fact learning in complex arithmetic—the role of the angular gyrus revisited
2016-04-30

Abstract In recent theoretical considerations as well as in neuroimaging findings the left angular gyrus (AG) has been associated with the retrieval of arithmetic facts. This interpretation was corroborated by higher AG activity when processing trained as compared with untrained multiplication problems. However, so far neural correlates of processing trained versus untrained problems were only compared after training. We employed an established learning paradigm (i.e., extensive training of multiplication problems) but measured brain activation before and afte training to evaluate neural correlates of arithmetic fact acquisition more specifically. When comparing activation patterns for trained and untrained problems of the post‐training session, higher AG activation for trained problems was replicated. However, when activation for trained problems was compared to activation for the same problems in the pre‐training session, no signal change in the AG was observed. Instead, our results point toward a central role of hippocampal, para‐hippocampal, and retrosplenial structures in arithmetic fact retrieval. We suggest that the AG might not be associated with the actual retrieval of arithmetic facts, and outline an attentional account of the role of the AG in arithmetic fact retrieval that is compatible with recent attention to memory hypotheses. Hum Brain Mapp 37:3061–3079, 2016 . © 2016 Wiley Periodicals, Inc.