julilili42/papers huggingface dataset:
Three-nucleon dynamics in dp breakup collisions using the WASA detector at COSY-Jülich
2020-04-13

Differential cross section for the 1H(d,pp)n breakup reaction at deuteron beam energy of 340 MeV has been measured with the use of WASA detector at COSY-Juelich. The set of proton-proton coincidences registered at Forward Detector has been analysed on dense grid of kinematic variables, giving in total around 5600 data points. The cross section data are compared to theoretical predictions based on the state-of-the-art nucleon-nucleon potentials, combined with three-nucleon force, Coulomb interaction or carried out in a relativistic regime.
An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature
2020-04-13

Abstract Context C-type natriuretic peptide (CNP) is critically involved in endochondral bone growth. Variants in the genes encoding CNP or its cyclic guanosine monophosphate (cGMP)-forming receptor (natriuretic peptide receptor-B [NPR-B], gene NPR2) cause monogenic growth disorders. Here we describe a novel gain-of-function variant of NPR-B associated with tall stature and macrodactyly of the great toes (epiphyseal chondrodysplasia, Miura type). Design History and clinical characteristics of 3 family members were collected. NPR2 was selected for sequencing. Skin fibroblasts and transfected HEK-293 cells were used to compare mutant versus wild-type NPR-B activities. Homology modeling was applied to understand the molecular consequences of the variant. Results Mother’s height was +2.77 standard deviation scores (SDS). The heights of her 2 daughters were +1.96 SDS at 7 years and +1.30 SDS at 4 years of age. Skeletal surveys showed macrodactyly of the great toes and pseudo-epiphyses of the mid- and proximal phalanges. Sequencing identified a novel heterozygous variant c.1444_1449delATGCTG in exon 8 of NPR2, predicted to result in deletion of 2 amino acids Met482-Leu483 within the submembrane region of NPR-B. In proband’s skin fibroblasts, basal cGMP levels and CNP-stimulated cGMP production were markedly increased compared with controls. Consistently, assays with transfected HEK-293 cells showed markedly augmented baseline and ligand-dependent activity of mutant NPR-B. Conclusions We report the second activating variant within the intracellular submembrane region of NPR-B resulting in tall stature and macrodactyly. Our functional and modeling studies suggest that this domain plays a critical role in the baseline conformation and ligand-dependent structural rearrangement of NPR-B required for cGMP production.
Complement activation at the interface of wound dressings and blood does not influence keratinocyte migration/proliferation in vitro
2020-04-13

Abstract Recently, we reported that some wound dressings caused complement activation at the interface of wound dressing and blood. Since complement activation is associated with impaired wound healing, we investigated whether this activation of the complement cascade at the interface of wound dressings and blood does impair reepithelialization in a scratch wound healing assay. Although some samples showed higher levels of the complement activation marker SC5b‐9 in our study, reepithelialization of the samples did not significantly differ from the control group. Further studies have to clarify if complement activation at the interface of wound dressings and blood plays a relevant role in the healing process especially in long‐time experiments.
Conspiracy theories and their societal effects during the COVID-19 pandemic
2020-04-14

During COVID-19, conspiracy theories were intensely discussed in the media. Believing in specific conspiracy theories (i.e., explanations for events based on powerholders’ secret arrangements) as well as the general tendency to believe in conspiracy theories—a so-called conspiracy mentality—have been found to predict cognition and behavior with negative societal effects, such as low institutional trust. Accordingly, believing in conspiracy theories around COVID-19 should work against institutional trust, support of governmental regulations and their adoption, as well as societal engagement (e.g., helping members of risk groups). We tested these predictions in a national random sample, an experimental study, and a longitudinal study (Ntotal = 1,213; all studies preregistered). Indeed, believing in and being confronted with a COVID-19 conspiracy theory decreased institutional trust, support of governmental regulations, adoption of physical distancing, and—to some extent—social engagement. Findings underscore that conspiracy theories have severe societal effects in the context of COVID-19.
The Plasma Membrane—An Integrating Compartment for Mechano-Signaling
2020-04-14

Plants are able to sense their mechanical environment. This mechanical signal is used by the plant to determine its phenotypic features. This is true also at a smaller scale. Morphogenesis, both at the cell and tissue level, involves mechanical signals that influence specific patterns of gene expression and trigger signaling pathways. How a mechanical stress is perceived and how this signal is transduced into the cell remains a challenging question in the plant community. Among the structural components of plant cells, the plasma membrane has received very little attention. Yet, its position at the interface between the cell wall and the interior of the cell makes it a key factor at the nexus between biochemical and mechanical cues. So far, most of the key players that are described to perceive and maintain mechanical cell status and to respond to a mechanical stress are localized at or close to the plasma membrane. In this review, we will focus on the importance of the plasma membrane in mechano-sensing and try to illustrate how the composition of this dynamic compartment is involved in the regulatory processes of a cell to respond to mechanical stress.
Dominant Role of Heterojunctions in Gas Sensing with Composite Materials
2020-04-14

It is well known that composite materials, consisting of at least two metal oxides, show qualities and sensing behavior very different from the single components. Recently, the preparation of core-shell nanomaterials for gas sensors has become extremely popular. Specifically, these materials have been found to show desirable sensor responses. The preparation of core-shell nanomaterials is, however, complex, limiting the commercial applicability. Composite materials can be more easily attained simply through the mechanical mixing of the various components. Although some studies exist that attempt to compare mechanically mixed composites to those prepared via a synthetic route, these examinations are often flawed, as due to varying preparation methods, the basic characteristics of the materials are not the same. Here, it was possible to separate the role of the contacts between the materials from that of the secondary core-shell structure, by using a soft method to mechanically break apart the structure. This ensures that the difference in morphology is the only change in the material characteristics. It was verified that the composite materials show a different sensing behavior from that of the pure materials. It was also found that regardless of the secondary structure, the composite materials showed very similar sensor responses. By examining materials containing different ratios of Cr<sub>2</sub>O<sub>3</sub> to SnO<sub>2</sub>, it was possible to attribute the sensor behavior changes to the contacts between the different metal oxides. It was shown that by varying the concentration of each oxide it is possible to attain either an n- or p-type response and at a certain concentration even no response. This work is significant because it identifies that the contact between the materials plays the dominant role in the sensor response and it shows the viability of mechanical mixing for composite sample preparation.
Homophily in the formation and development of learning networks among university students
2020-04-14

Abstract Students’ personal learning networks can be a valuable resource of success in higher education: they offer opportunities for academic and personal support and provide sources of information related to exams or homework. We study the determinants of learning networks using a panel study among university students in their first and second year of study. A long-standing question in social network analysis has been whether the tendency of individuals with similar characteristics to form ties is a result of preferences “choice homophily” or rather selective opportunities “induced homophily”. We expect a latent preference for homophilic learning partnerships with regard to attributes, such as gender, ability, and social origin. We estimate recently developed temporal exponential random graph models to control for previous network structure and study changes in learning ties among students. The results show that especially for males, same-gender partnerships are preferred over heterogeneous ties, while chances for tie formation decrease with the difference in academic ability among students. Social origin is a significant factor in the crosssectional exploration but does appear to be less important in the formation of new (strong) partnerships during the course of studies.
Assessing Redox Properties of Natural Organic Matters with regard to Electron Exchange Capacity and Redox-Active Functional Groups
2020-04-14

Redox processes in groundwater play an important role in bioavailability, toxicity, and mobility of redox-active elements and contaminants. A recent study has demonstrated that low-molecular-weight fraction (LMWF) of humic substances with great number of redox-active functional groups (RAFGs) exhibits great reducing capacity. However, whether LMWF of natural organic matter (NOM) exhibits high redox capacity still remains unclear. Therefore, this study extracted Pahokee peat NOM (PPNOM) and Leonardite NOM (LNOM) from soils, and then LMWFs in these NOMs were collected using a dialysis method. Electron exchange capacities (EEC) and RAFGs of LMWF NOMs at different E h were analyzed using a novel electrochemical method and a three-dimensional excitation emission fluorescence (3DEEM) spectroscopy. We found that the reducing capacity in LMWF PPNOM was approximately 5-6 times higher than the bulk NOM, while only 7.8% LMWF PPNOM was accounted for in the bulk NOM. An increasing in EEC (EAC + EDC, where EAC is the electron accepting capacity and EDC is the electron donating capacity) of LMWF PPNOM and LNOM with E h reduced from −0.49 V to −0.69 V. Additionally, an obvious increase in fluorescent intensities of quinone-like fluorophores before and after being reduced LMWF LNOM is responsible for high EAC of LMWF LNOM. These findings provide a better understanding of relationship between RAFGs E h in LMWF of NOM, further helping in predicting and protection of groundwater environment and fate of transformation and transport for redox-active contaminants in groundwater.
Human exploitation of nocturnal felines at Diepkloof Rock Shelter provides further evidence for symbolic behaviours during the Middle Stone Age
2020-04-14

Abstract Within the animal kingdom, carnivores occupied a unique place in prehistoric societies. At times predators or competitors for resources and shelters, anthropogenic traces of their exploitation, often for non-nutritional purposes, permeate the archaeological record. Scarce but spectacular depictions in Palaeolithic art confirm peoples’ fascination with carnivores. In contrast with the European record, research on hominin/carnivore interactions in Africa has primarily revolved around the hunting or scavenging debate amongst early hominins. As such, the available information on the role of carnivores in Anatomically Modern Humans’ economic and cultural systems is limited. Here, we illustrate a particular relationship between humans and carnivores during the MIS5-4 Still Bay and Howiesons Poort techno-complexes at Diepkloof Rock Shelter, South Africa. The recovery of numerous felid remains, including cut-marked phalanges, tarsals and metapodials, constitutes direct evidence for carnivore skinning and, presumably, pelt use in the southern African Middle Stone Age. Carnivore exploitation at the site seems to have focused specifically on nocturnal, solitary and dangerous felines. The lines of evidence presented here suggest the capture and fur use of those felines in the context of highly codified and symbolically loaded cultural traditions.
Sedimentological Evidence for Pronounced Glacial‐Interglacial Climate Fluctuations in NE Tibet in the Latest Pliocene to Early Pleistocene
2020-04-14

Abstract The intensification of Northern Hemisphere glaciation (iNHG) and uplift of the Tibetan Plateau have been argued to be among the main drivers of climate change in midlatitude Central Asia during the Pliocene/Pleistocene. While most proxy records that support this hypothesis are from regions outside the Tibetan Plateau (such as from the Chinese Loess Plateau), detailed paleoclimatic information for the plateau itself during that time has yet remained elusive. Here we present a temporally highly resolved (~500 years) sedimentological record from the Qaidam Basin situated on the northeastern Tibetan Plateau that shows pronounced glacial‐interglacial climate variability during the interval from 2.7 to 2.1 Ma. Glacial (interglacial) intervals are generally characterized by coarser (finer) grain size, minima (maxima) in organic matter content, and maxima (minima) in carbonate content. Comparison of our results with Earth's orbital parameters and proxy records from the Chinese Loess Plateau suggests that the observed climate fluctuations were mainly driven by changes in the Siberian High/East Asian winter monsoon system as a response to the iNHG. They are further proposed to be enhanced by the topography of the Tibetan Plateau and its impact on the position and intensity of the westerlies.
Let’s (Not) (Dis)Agree to Disagree!? Some Thoughts on the ‘Dispute’ Requirement in International Adjudication
2020-04-14

Abstract International courts and tribunals only enjoy jurisdiction to settle a ‘dispute’. ‘Dispute’ requires disagreement. However, what if the parties disagree over whether there actually exists such disagreement? What if, before the International Court of Justice, the respondent argues that there is no ‘dispute’ because it declined to react to the applicant’s contentions? In other words, can a disputing party avoid a dispute by playing dead? On the other hand, where does one draw the line in order to prevent the applicant from seizing an international court or tribunal where there is in fact no real disagreement between the parties? This article critically assesses the Court’s case law on the ‘dispute’ requirement and argues for a fragmented approach to ‘dispute’ in international adjudication that carefully defines this jurisdictional requirement along the lines of the judicial function of the respective international judicial dispute settlement forum.
Homozygous BZRAP1 Mutations Cause Autosomal Recessive Dystonia (4419)
2020-04-14

Thursday, April 30April 14, 2020Free AccessHomozygous BZRAP1 Mutations Cause Autosomal Recessive Dystonia (4419)Niccolo Mencacci, Marisa Brockmann, Sander Pajusalu, Burcu Atasu, Paulina Gonzales Latapi, Michael Schwake, Bettina Balint, ... Show All ... , Apostolos Papandreou, Alan Pittman, Javier Simon-Sanchez, Sarah Wiethoff, Thomas Warner, Manju Kurian, Thomas Gasser, Ebba Lohmann, Katrin Ounap, Kailash Bhatia, Christian Rosenmund, Thomas Sudhof, Nicholas Wood, Dimitri Krainc, and Claudio Acuna Show FewerAuthors Info & AffiliationsApril 14, 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.4419 Letters to the Editor
Temporo-parietal brain regions are involved in higher order object perception
2020-04-14

Abstract Lesions to posterior temporo-parietal brain regions are associated with deficits in perception of global, hierarchical shapes, but also impairments in the processing of objects presented under demanding viewing conditions. Evidence from neuroimaging studies and lesion patterns observed in patients with simultanagnosia and agnosia for object orientation suggest similar brain regions to be involved in perception of global shapes and processing of objects in atypical (‘non-canonical’) orientation. In a localizer experiment, we identified individual temporoparietal brain areas involved in global shape perception and found significantly higher BOLD signals during the processing of non-canonical compared to canonical objects. In a multivariate approach, we demonstrated that posterior temporo-parietal brain areas show distinct voxel patterns for non-canonical and canonical objects and that voxel patterns of global shapes are more similar to those of objects in non-canonical compared to canonical viewing conditions. These results suggest that temporo-parietal brain areas are not only involved in global shape perception but might serve a more general mechanism of complex object perception. Our results challenge a strict attribution of object processing to the ventral visual stream by suggesting specific dorsal contributions in more demanding viewing conditions. Highlights Posterior temporo-parietal brain areas in the TPJ region that are involved in global shape perception are significantly involved in object perception Individual global shape TPJ ROIs identified with a specific localizer experiment prefer objects in non-canonical over objects in canonical orientations Univariate activations and multivariate voxel patterns in global shape TPJ ROIs distinguish canonical and non-canonical object presentations
Brain insulin sensitivity is linked to adiposity and body fat distribution
2020-04-15

Abstract Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass during a nine year follow-up. Cross-sectionally, strong insulin responsiveness of the hypothalamus associates with less visceral fat, while subcutaneous fat is unrelated. Our results demonstrate that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution. Since visceral fat is strongly linked to diabetes, cardiovascular risk and cancer, these findings have implications beyond metabolic diseases and indicate the necessity of strategies to resolve brain insulin resistance.
An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease
2020-04-15

The Paneth cells reside in the small intestine at the bottom of the crypts of Lieberkühn, intermingled with stem cells, and provide a niche for their neighbors by secreting growth and Wnt-factors as well as different antimicrobial peptides including defensins, lysozyme and others. The most abundant are the human Paneth cell α-defensin 5 and 6 that keep the crypt sterile and control the local microbiome. In ileal Crohn's disease various mechanisms including established genetic risk factors contribute to defects in the production and ordered secretion of these peptides. In addition, life-style risk factors for Crohn's disease like tobacco smoking also impact on Paneth cell function. Taken together, current evidence suggest that defective Paneth cells may play the key role in initiating inflammation in ileal, and maybe ileocecal, Crohn's disease by allowing bacterial attachment and invasion.
Patients' views on the ethical challenges of early Parkinson disease detection
2020-04-15

Although patients with PD reported the time to diagnosis retrospectively as burdensome, the majority was skeptical regarding early disclosure of risk, especially with regard to the lack of pharmacologic options. Circumstances under which early detection and disclosure would have been approved by the majority of patients were (1) advice on lifestyle changes (exercise, nutrition) as potentially disease course-modifying therapy; (2) the establishment of an early diagnosis "culture," including early clarification of the patients' wish to know; and (3) regular support and follow-up of individuals after risk disclosure.
Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model
2020-04-15

Antiviral therapies against influenza are required, especially for high-risk patients, severe influenza and in case of highly pathogenic influenza virus (IV) strains. However, currently, licensed drugs that target the virus directly are not very effective and often lead to the development of resistant IV variants. This may be overcome by targeting host cell factors that are required for IV propagation. IV induces a variety of host cell signaling cascades, such as the Raf/MEK/ERK kinase pathway. The activation of this pathway is necessary for IV propagation. MEK-inhibitors block the activation of the pathway on the bottleneck of the signaling cascade leading to impaired virus propagation. In the present study, we aimed to compare the antiviral potency and bioavailability of the MEK-inhibitor CI-1040 versus its major active metabolite ATR-002, in vitro as well as in the mouse model. In cell culture assays, an approximately 10-fold higher concentration of ATR-002 is required to generate the same antiviral activity as for CI-1040. Interestingly, we observed that considerably lower concentrations of ATR-002 were required to achieve a reduction of the viral load in vivo. Pharmacokinetic studies with ATR-002 and CI-1040 in mice have found the C<sub>max</sub> and AUC to be far higher for ATR-002 than for CI-1040. Our results thereby demonstrate the in vivo superiority of the active metabolite ATR-002 over CI-1040 as an antiviral agent despite its weaker cell membrane permeability. Therefore, ATR-002 is an attractive candidate for development as an efficient antiviral agent, especially given the fact that a treatment based on cellular pathway inhibition would be far less likely to lead to viral drug resistance.
Trajectory phase transitions in noninteracting spin systems
2020-04-15

We show that a collection of independent Ising spins evolving stochastically can display surprisingly large fluctuations toward ordered behavior, as quantified by certain types of time-integrated plaquette observables, despite the underlying dynamics being noninteracting. In the large-deviation (LD) regime of long times and large system size, this can give rise to a phase transition in trajectory space. As a noninteracting system we consider a collection of spins undergoing single spin-flip dynamics at infinite temperature. For the dynamical observables we study, the associated tilted generators have an exact and explicit spin-plaquette duality. Such setup suggests the existence of a transition (in the large size limit) at the self-dual point of the tilted generator. The nature of the LD transition depends on the observable. We consider explicitly two situations: (i) for a pairwise bond observable the LD transition is continuous and equivalent to that of the transverse field Ising model and (ii) for a higher-order plaquette observable, in contrast, the LD transition is first order. Case (i) is easy to prove analytically, while we confirm case (ii) numerically via an efficient trajectory sampling scheme that exploits the noninteracting nature of the original dynamics.