julilili42/papers huggingface dataset:
Identifying Droughts Affecting Agriculture in Africa Based on Remote Sensing Time Series between 2000–2016: Rainfall Anomalies and Vegetation Condition in the Context of ENSO
2017-08-11

Droughts are amongst the most destructive natural disasters in the world. In large regions of Africa, where water is a limiting factor and people strongly rely on rain-fed agriculture, droughts have frequently led to crop failure, food shortages and even humanitarian crises. In eastern and southern Africa, major drought episodes have been linked to El Niño-Southern Oscillation (ENSO) events. In this context and with limited in-situ data available, remote sensing provides valuable opportunities for continent-wide assessment of droughts with high spatial and temporal resolutions. This study aimed to monitor agriculturally relevant droughts over Africa between 2000–2016 with a specific focus on growing seasons using remote sensing-based drought indices. Special attention was paid to the observation of drought dynamics during major ENSO episodes to illuminate the connection between ENSO and droughts in eastern and southern Africa. We utilized Tropical Rainfall Measuring Mission (TRMM)-based Standardized Precipitation Index (SPI) with 0 . 25 ∘ resolution and Moderate-resolution Imaging Spectroradiometer (MODIS)-derived Vegetation Condition Index (VCI) with 500 m resolution as indices for analysing the spatio-temporal patterns of droughts. We combined the drought indices with information on the timing of site-specific growing seasons derived from MODIS-based multi-annual average of Normalized Difference Vegetation Index (NDVI). We proved the applicability of SPI-3 and VCI as indices for a comprehensive continental-scale monitoring of agriculturally relevant droughts. The years 2009 and 2011 could be revealed as major drought years in eastern Africa, whereas southern Africa was affected by severe droughts in 2003 and 2015/2016. Drought episodes occurred over large parts of southern Africa during strong El Niño events. We observed a mixed drought pattern in eastern Africa, where areas with two growing seasons were frequently affected by droughts during La Niña and zones of unimodal rainfall regimes showed droughts during the onset of El Niño. During La Niña 2010/2011, large parts of cropland areas in Somalia (88%), Sudan (64%) and South Sudan (51%) were affected by severe to extreme droughts during the growing seasons. However, no universal El Niño- or La Niña-related response pattern of droughts could be deduced for the observation period of 16 years. In this regard, we discussed multi-year atmospheric fluctuations and characteristics of ENSO variants as further influences on the interconnection between ENSO and droughts. By utilizing remote sensing-based drought indices focussed on agricultural zones and periods, this study attempts to contribute to a better understanding of spatio-temporal patterns of droughts affecting agriculture in Africa, which can be essential for implementing strategies of drought hazard mitigation.
Massively parallel GPU-accelerated minimization of classical density functional theory
2017-08-11

In this paper, we discuss the ability to numerically minimize the grand potential of hard disks in two-dimensional and of hard spheres in three-dimensional space within the framework of classical density functional and fundamental measure theory on modern graphics cards. Our main finding is that a massively parallel minimization leads to an enormous performance gain in comparison to standard sequential minimization schemes. Furthermore, the results indicate that in complex multi-dimensional situations, a heavy parallel minimization of the grand potential seems to be mandatory in order to reach a reasonable balance between accuracy and computational cost.
Life-span of in vitro differentiated Plasmodium falciparum gametocytes
2017-08-11

Plasmodium falciparum mature gametocytes can survive up to 16-32 days (at least 14 days for mature male gametocytes) in vitro in absence of the influence of host factors. This confirms experimentally a previous modelling estimate that used molecular tools for gametocyte detection in treated patients. The survival time might reflect the time the parasite can be transmitted to the mosquito after clearance of asexual parasites. These results underline the importance of efficient transmission blocking agents in the fight against malaria.
Facial microcirculatory and biomechanical skin properties after single high energy (Er):YAG laser application
2017-08-11

Objective Owing to skin aging and the growing demand for skin rejuvenation, minimal invasive aesthetic treatments such as laser procedures are increasingly coming into focus. However, until now, little has been known about the objective effects of these procedures with respect to skin microcirculation or changes in skin elasticity. Study Design Facial skin rejuvenation was performed on 32 volunteers using ablative Erbium: YAG laser. Skin microcirculation and skin elasticity have then been evaluated objectively. Methods Microcirculation (flow, SO 2 , velocity, and rHB) has been analyzed before and directly after the laser session by using the O2C device. Skin elasticity has been evaluated by using the Cutometer device (Uf, Ua, Ur, and Ue) before and directly after the laser treatment, as well as 1 week and then 1, 3, and 6 months post treatment. Further, the outcome for the volunteers regarding their satisfactory level after laser treatment was evaluated. Results Twenty volunteers were available for a complete follow‐up. Microcirculation displayed statistically significant increase in all values to 2 mm depth. The biomechanical skin parameter of firmness of skin displayed statistically significant improvement in superficial skin layer after 6 months. Conclusion Concerning microcirculation and skin elasticity the ablative Erbium: YAG laser treatment revealed similar effects on the skin like a superficial burn injury. In contrast to the determined skin elasticity parameters, firmness of skin objectively revealed a skin tightening effect after 6 months. Along with the important epidermal effect, the suitability of ablative laser treatment for skin rejuvenation has been proved in a long‐term follow‐up. Lasers Surg. Med. 49:891–898, 2017. © 2017 Wiley Periodicals, Inc.
Visual Receptive Field Heterogeneity and Functional Connectivity of Adjacent Neurons in Primate Frontoparietal Association Cortices
2017-08-11

The basic organization principles of the primary visual cortex (V1) are commonly assumed to also hold in the association cortex such that neurons within a cortical column share functional connectivity patterns and represent the same region of the visual field. We mapped the visual receptive fields (RFs) of neurons recorded at the same electrode in the ventral intraparietal area (VIP) and the lateral prefrontal cortex (PFC) of rhesus monkeys. We report that the spatial characteristics of visual RFs between adjacent neurons differed considerably, with increasing heterogeneity from VIP to PFC. In addition to RF incongruences, we found differential functional connectivity between putative inhibitory interneurons and pyramidal cells in PFC and VIP. These findings suggest that local RF topography vanishes with hierarchical distance from visual cortical input and argue for increasingly modified functional microcircuits in noncanonical association cortices that contrast V1. SIGNIFICANCE STATEMENT Our visual field is thought to be represented faithfully by the early visual brain areas; all the information from a certain region of the visual field is conveyed to neurons situated close together within a functionally defined cortical column. We examined this principle in the association areas, PFC, and ventral intraparietal area of rhesus monkeys and found that adjacent neurons represent markedly different areas of the visual field. This is the first demonstration of such noncanonical organization of these brain areas.
Differential changes in self-reported aspects of interoceptive awareness through 3 months of contemplative training
2017-08-11

Interoceptive body awareness (IA) is crucial for psychological well-being and plays an important role in many contemplative traditions. However, until recently, standardized self-report measures of IA were scarce, not comprehensive, and the effects of interoceptive training on such measures were largely unknown. The Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire measures IA with eight different scales. In the current study, we investigated whether and how these different aspects of IA are influenced by a 3-months contemplative intervention in the context of the ReSource project, in which 148 subjects engaged in daily practices of “Body Scan” and “Breath Meditation.” We developed a German version of the MAIA and tested it in a large and diverse sample (n = 1,076). Internal consistencies were similar to the English version (0.56– 0.89), retest reliability was high (r s: 0.66–0.79), and the MAIA showed good convergent and discriminant validity. Importantly, interoceptive training improved five out of eight aspects of IA, compared to a retest control group. Participants with low IA scores at baseline showed the biggest changes. Whereas practice duration only weakly predicted individual differences in change, self-reported liking of the practices and degree of integration into daily life predicted changes on most scales. Interestingly, the magnitude of observed changes varied across scales. The strongest changes were observed for the regulatory aspects of IA, that is, how the body is used for self-regulation in daily life. No significant changes were observed for the Noticing aspect (becoming aware of bodily changes), which is the aspect that is predominantly assessed in other IA measures. This differential pattern underscores the importance to assess IA multi-dimensionally, particularly when interested in enhancement of IA through contemplative practice or other mind–body interventions.
Enriching how-to guides with actionable phrases and linked data
2017-08-11

The World Wide Web contains a large quantity of community created knowledge of instructional nature. Similarly, in a commercial setting, databases of instructions are used by customer-care providers to guide clients in the resolution of issues. Most of these instructions are expressed in natural la nguage. Knowledge Bases including such information are valuable through the sum of their single entries. However, as each entry is created mostly independently, users (e.g. other community members) cannot take advantage of the accumulated knowledge that can be developed via the aggregation of related entries and of relevant information that can be found in external knowledge bases. In this paper we consider the problem of linking Knowledge Base entries to other relevant parts of the Knowledge Base and to third-party semi-structured knowledge sources. To achieve this, we propose (i) a new method to detect actionable phrases – text fragments that describe how to perform a certain action – and link them to other entries; and (ii) a new method to detect entities and link them to the Linked Open Data cloud. The method that we implemented for extracting actionable phrases achieves an F-score of 67.35%. We show that limiting the linking space to actionable phrases results in better linking quality than using coarser-grained spans of text, as proposed in other approaches to the task. In addition, we propose a new Linked Open Data linking method that uses a global optimization score to filter the set of possible candidates, increasing precision when compared to a standard method implemented in dbpedia-spotlight. Besides the above scientific contributions, we also present a detailed error analysis, and release our annotations to the community to foster future research on the subject.
NANOCI—Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons
2017-08-12

Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intracochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages.
Microvascular and lymphovascular tumour invasion are associated with poor prognosis and metastatic spread in renal cell carcinoma: a validation study in clinical practice
2017-08-13

Objective To validate microvascular (MVI) and lymphovascular (LVI) invasion as prognostic factors in patients with renal cell carcinoma (RCC). Patients and Methods Data of patients with RCC who underwent radical or nephron‐sparing surgery were prospectively collected from three academic centres. The occurrence of MVI and LVI was determined with standard staining protocols by experienced pathologists at the time of diagnosis. The association of MVI and LVI with clinicopathological data, metastatic spread, and cancer‐specific survival (CSS) were evaluated with Fisher's exact tests, binary logistic regression analyses, and univariable and multivariable Cox proportional hazard regression models. Results MVI was present in 201 of 747 patients (26.9%) and was associated with advanced Tumour‐Node‐Metastasis (TNM) stages, high Fuhrman grades, and sarcomatoid features (all P &lt; 0.001). MVI was associated with a higher rate of metastatic spread. LVI was present in 32 of 573 patients (5.5%) and was associated with advanced TNM stages, high Fuhrman grade, and sarcomatoid features (all P &lt; 0.001). Two‐thirds of LVI‐positive patients died ( P &lt; 0.001). Both LVI and MVI were significantly associated with CSS in all patients, clear cell RCC (ccRCC), and localised RCC in univariable analysis (all P &lt; 0.001). On multivariable analysis, presence of MVI was identified as an independent prognostic factor (hazard ratio 2.09; P = 0.001). Moreover, MVI [odds ratio (OR) 2.7; P = 0.001] and not macrovascular invasion ( P = 0.895) was an independent predictor of sychronuous metastatic spread. LVI was the strongest factor associated with sychronous metastatic spread (OR 4.73, 95% confidence interval 1.84–12.14; P = 0.001) in all patients and in the subgroup of patients with ccRCC ( P = 0.001). Conclusions The present study validated LVI and MVI as prognostic factors for poor outcome in RCC. These findings endorse an evaluation of both variables in the clinical routine setting to facilitate survival prognostication in follow‐up protocols and for assignment to adjuvant treatment trials.
The influence of speed abilities and technical skills in early adolescence on adult success in soccer: A long-term prospective analysis using ANOVA and SEM approaches
2017-08-14

Several talent development programs in youth soccer have implemented motor diagnostics measuring performance factors. However, the predictive value of such tests for adult success is a controversial topic in talent research. This prospective cohort study evaluated the long-term predictive value of 1) motor tests and 2) players' speed abilities (SA) and technical skills (TS) in early adolescence. The sample consisted of 14,178 U12 players from the German talent development program. Five tests (sprint, agility, dribbling, ball control, shooting) were conducted and players' height, weight as well as relative age were assessed at nationwide diagnostics between 2004 and 2006. In the 2014/15 season, the players were then categorized as professional (n = 89), semi-professional (n = 913), or non-professional players (n = 13,176), indicating their adult performance level (APL). The motor tests' prognostic relevance was determined using ANOVAs. Players' future success was predicted by a logistic regression threshold model. This structural equation model comprised a measurement model with the motor tests and two correlated latent factors, SA and TS, with simultaneous consideration for the manifest covariates height, weight and relative age. Each motor predictor and anthropometric characteristic discriminated significantly between the APL (p < .001; η2 ≤ .02). The threshold model significantly predicted the APL (R2 = 24.8%), and in early adolescence the factor TS (p < .001) seems to have a stronger effect on adult performance than SA (p < .05). Both approaches (ANOVA, SEM) verified the diagnostics' predictive validity over a long-term period (≈ 9 years). However, because of the limited effect sizes, the motor tests' prognostic relevance remains ambiguous. A challenge for future research lies in the integration of different (e.g., person-oriented or multilevel) multivariate approaches that expand beyond the "traditional" topic of single tests' predictive validity and toward more theoretically founded issues.
Human remains and funerary rites in the Phoenician Necropolis of Motya (Sicily)
2017-08-14

The aim of this paper is to examine the fresh evidence retrieved in the early cemetery or ‘archaic necropolis’ (8th-6th century BC) on the island of Motya, one of the main Phoenician colonies in the Mediterranean. Because of its integrity and the large number of finds, the cemetery has been considered one of the most relevant sites for the study of early burial customs in the West. The absence of anthropological data, completely neglected in the past, was a major shortcoming of previous research. This failing is now being rectified by a new project of fieldwork and excavation undertaken on the island by a team from Palermo University. This report provides a close examination of the human remains from a group of 32 graves discovered during three seasons (2013-2015) in a combined archaeological and taphonomic perspective, and contributes to shed light on the funerary practices of the Phoenicians in Sicily.
Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels
2017-08-15

Opioids, agonists of μ-opioid receptors (μORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects. However, μORs are also found on the peripheral endings of nociceptors and their activation there produces meaningful analgesia. The cellular mechanisms downstream of peripheral μORs are not well understood. Here, we show in neurons of murine dorsal root ganglia that pro-nociceptive TRPM3 channels, present in the peripheral parts of nociceptors, are strongly inhibited by μOR activation, much more than other TRP channels in the same compartment, like TRPV1 and TRPA1. Inhibition of TRPM3 channels occurs via a short signaling cascade involving Gβγ proteins, which form a complex with TRPM3. Accordingly, activation of peripheral μORs in vivo strongly attenuates TRPM3-dependent pain. Our data establish TRPM3 inhibition as important consequence of peripheral μOR activation indicating that pharmacologically antagonizing TRPM3 may be a useful analgesic strategy.
Function-related replacement of bacterial siderophore pathways
2017-08-15

Abstract Bacterial genomes are rife with orphan biosynthetic gene clusters (BGCs) associated with secondary metabolism of unrealized natural product molecules. Often up to a tenth of the genome is predicted to code for the biosynthesis of diverse metabolites with mostly unknown structures and functions. This phenomenal diversity of BGCs coupled with their high rates of horizontal transfer raise questions about whether they are really active and beneficial, whether they are neutral and confer no advantage, or whether they are carried in genomes because they are parasitic or addictive. We previously reported that Salinispora bacteria broadly use the desferrioxamine family of siderophores for iron acquisition. Herein we describe a new and unrelated group of peptidic siderophores called salinichelins from a restricted number of Salinispora strains in which the desferrioxamine biosynthesis genes have been lost. We have reconstructed the evolutionary history of these two different siderophore families and show that the acquisition and retention of the new salinichelin siderophores co-occurs with the loss of the more ancient desferrioxamine pathway. This identical event occurred at least three times independently during the evolution of the genus. We surmise that certain BGCs may be extraneous because of their functional redundancy and demonstrate that the relative evolutionary pace of natural pathway replacement shows high selective pressure against retention of functionally superfluous gene clusters.
Posterior translacrimal approach to the maxillary sinus
2017-08-15

Abstract Background: This study aimed to compare the view into the maxillary sinus using the posterior translacrimal approach compared with grade 3 antrostomy. Methods: Grade 3 antrostomy followed by a posterior translacrimal approach was performed on four cadavers. The maximum intramaxillary view was documented endoscopically guided by electromagnetic navigation. Representative screenshots were evaluated in a blinded manner by three independent sinus surgeons. In addition, a prospective investigation of specific complications in the post-operative course of consecutive patients was performed. Results: In the cadaver study, the posterior translacrimal approach provided a significantly better view into the maxillary sinus compared with grade 3 antrostomy. In the clinical study, only 1 out of 20 patients reported on a minor problem with lacrimal drainage at 6 months. Conclusion: The posterior translacrimal approach to visualising the maxillary sinus should be considered a strong alternative to more radical techniques.
Human Remains and Funerary Rites in the Phoenician Necropolis of Motya (Sicily)
2017-08-15

Abstract The aim of this paper is to examine the fresh evidence retrieved in the early cemetery or ‘archaic necropolis’ (eighth to sixth century bc ) on the island of Motya, one of the main Phoenician colonies in the Mediterranean. Because of its integrity and the large number of finds, the cemetery has been considered one of the most relevant sites for the study of early burial customs in the West. The absence of anthropological data, completely neglected in the past, was a major shortcoming of previous research. This failing is now being rectified by a new project of fieldwork and excavation undertaken on the island by a team from Palermo University. This report provides a close examination of the human remains from a group of 32 graves discovered during three seasons (2013–2015) in a combined archaeological and taphonomic perspective and contributes to shed light on the funerary practices of the Phoenicians in Sicily. Copyright © 2017 John Wiley &amp; Sons, Ltd.