julilili42/papers huggingface dataset:
1603: PTEN - AKT- P27 KIP1 Expression Profile in Benign, Cancerous, Lymph Node Positive and Hormone Refractory Prostate Cancer Tissue
2005-04-01

You have accessJournal of UrologyModerated Poster, Wednesday, May 25, 2005, 1:00 - 3:00 pm1 Apr 20051603: PTEN - AKT- P27 KIP1 Expression Profile in Benign, Cancerous, Lymph Node Positive and Hormone Refractory Prostate Cancer Tissue Axel S. Merseburger, Joerg Hennenlotter, Marcus Horstmann, Ruth Knuechel-Clarke, Carolin Mueller, Perikles Simon, Aristoteles G. Anastasiadis, Arnulf Stenzl, and Markus A. Kuczyk Axel S. MerseburgerAxel S. Merseburger More articles by this author , Joerg HennenlotterJoerg Hennenlotter More articles by this author , Marcus HorstmannMarcus Horstmann More articles by this author , Ruth Knuechel-ClarkeRuth Knuechel-Clarke More articles by this author , Carolin MuellerCarolin Mueller More articles by this author , Perikles SimonPerikles Simon More articles by this author , Aristoteles G. AnastasiadisAristoteles G. Anastasiadis More articles by this author , Arnulf StenzlArnulf Stenzl More articles by this author , and Markus A. KuczykMarkus A. Kuczyk More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35725-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1603: PTEN - AKT- P27 KIP1 Expression Profile in Benign, Cancerous, Lymph Node Positive and Hormone Refractory Prostate Cancer Tissue." The Journal of Urology, 173(4S), p. 434 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 434 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Axel S. Merseburger More articles by this author Joerg Hennenlotter More articles by this author Marcus Horstmann More articles by this author Ruth Knuechel-Clarke More articles by this author Carolin Mueller More articles by this author Perikles Simon More articles by this author Aristoteles G. Anastasiadis More articles by this author Arnulf Stenzl More articles by this author Markus A. Kuczyk More articles by this author Expand All Advertisement Loading ...
4D data processing for dynamic human body analysis
2005-04-01

It is expected that the next generation of full 3D optical scanning systems will be able to measure volumetric objects in motion. Standard data representations like point clouds or sets of triangle meshes, which are used nowadays for static 3D objects, will no longer be an efficient solution in this field. Systems of this kind will have to use other data processing and representation methods. We propose our own solution in this paper, using an arbitrary full 3D mesh which is scaled and wrapped around a merged point cloud obtained from the measurements, instead of a standard point cloud representation. This solution was specifically prepared for a prototype of a full-field 4D scanning system. This system is based on a dynamic laser triangulation. Four scanners capture a surface of a moving object from four different directions simultaneously. They are calibrated in time and space so finally we can obtain a full 3D object surface which changes in time. In this paper we present some details of the scanning system, 4D surface representation, general 4D data processing pipeline, developed algorithms and we finally show some exemplary results of our work in this field.
Implicit operant learning of pain sensitization
2005-04-04

Operant conditioning mechanisms have been demonstrated to be important in the development of chronic pain behavior, but it is not clear whether and how this extends to pain perception itself. The fear-avoidance theory suggests that hypersensitivity may be induced by anticipatory pain avoidance learned through negative reinforcement by acute reductions of pain and fear. But the precise mechanism of the assumed 'sensory decalibration' has not been specified. The present study with healthy subjects investigated whether operant learning of enhanced short-term sensitization may provide the 'proximal' mechanism and whether gradual learning of hypersensitivity can take place without subjects' awareness. We used an experimental model of implicit learning based on a behavioral adjustment method of sensitization measurement developed and validated previously, combining it with standard methods of operant response shaping of increased sensitization or habituation. Results indicated that operant discrimination training with reinforcement of short-term sensitization in the seconds range can produce gross up or down changes in sensitivity within an hour without subjects' awareness of reinforcement contingencies. Consequently, implicit learning of enhanced pain sensitization may be a suitable model to investigate operant plasticity of pain perception in addition to basic sensory and neuronal mechanisms and to link these with the clinical construct of pain-fear avoidance.
Non‐host resistance in plants: new insights into an old phenomenon
2005-04-05

SUMMARY Resistance of an entire plant species to all isolates of a microbial species is referred to as non‐host or species resistance. An interplay of both constitutive barriers and inducible reactions comprises the basis for this most durable form of plant disease resistance. Activation of inducible plant defence responses is probably brought about by the recognition of invariant pathogen‐associated molecular patterns (PAMP) that are characteristic of whole classes of microbial organisms. PAMP perception systems and PAMP‐induced signalling cascades partially resemble those known to mediate activation of innate immune responses in animals, suggesting an evolutionarily ancient molecular concept of non‐self recognition and immunity in eukaryotes. Genetic dissection has recently provided clues for SNARE‐complex‐mediated exocytosis and directed vesicle trafficking in executing plant non‐host resistance. Recent functional analysis of bacterial effector proteins indicates that establishment of infection in susceptible plants is associated with suppression of plant species resistance.
3D modeling of indoor environments by a mobile robot with a laser scanner and panoramic camera
2005-04-06

&lt;p&gt;We present a method to acquire a realistic, visually convincing 3D model of indoor office environments based on a mobile robot that is equipped with a laser range scanner and a panoramic camera. The data of the 2D laser scans are used to solve the SLAM problem and to extract walls. Textures for walls and floor are built from the images of a calibrated panoramic camera. Multi-resolution blending is used to hide seams in the generated textures.&lt;/p&gt;
A finite size pencil beam for IMRT dose optimization
2005-04-06

Dose optimization for intensity modulated radiotherapy (IMRT) using small field elements (beamlets) requires the computation of a large number of very small, often only virtual fields of typically a few mm to 1 cm in size. The primary requirements for a suitable dose computation algorithm are (1) speed and (2) proper consideration of the penumbra of the fields which are composed of these beamlets. Here, a finite size pencil beam (fsPB) algorithm is proposed which was specifically designed for the purpose of beamlet-based IMRT. The algorithm employs an analytical function for the cross-profiles of the beamlets which is based on the assumption of self-consistency, i.e. the requirement that an arbitrary superposition of abutting beamlets should add up to a homogeneous field. The depth dependence is stored in tables derived from Monte Carlo computed dose distributions. It is demonstrated that the algorithm produces accurately the output factors and cross-profiles of typical multi-leaf-shaped segments. Due to the accurate penumbra model, the dose distribution features physically feasible gradients at any stage of the iterative optimization, which eliminates the problem of large discrepancies in normal tissue dose due to misaligned gradients between optimized and recomputed treatment plans.
Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)–negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH
2005-04-06

Abstract Telomere length has been linked to disease stage and degree of (pan-)cytopenia in patients with bone marrow failure syndromes. The aim of the current study was to analyze the impact of replicative stress on telomere length in residual glycosylphosphatidylinositol-positive (GPI+) versus GPI– hematopoiesis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Peripheral blood granulocytes from 16 patients and 22 healthy individuals were analyzed. For this purpose, we developed proaerolysin flow-FISH, a novel methodology that combines proaerolysin staining (for GPI expression) with flow-FISH (for telomere length measurement). We found significantly shortened telomeres in GPI– granulocytes (mean ± SE: 6.26 ± 0.27 telomere fluorescence units [TFU]), both compared with their GPI+ counterparts (6.88 ± 0.38 TFU; P = .03) as well as with age-matched healthy individuals (7.73 ± 0.23 TFU; P &amp;lt; .001). Our findings are in support of a selective growth advantage model of PNH assuming that damage to the GPI+ hematopoietic stem-cell (HSC) compartment leads to compensatory hyperproliferation of residual GPI–HSCs.
An invariant operator due to F Klein quantizes H Poincaré's dodecahedral 3-manifold
2005-04-06

The eigenmodes of the Poincar\\\\'e dodecahedral 3-manifold are constructed\\nas eigenstates of a novel invariant operator. The topology of is\\ncharacterized by the homotopy group , given by loop composition on\\n , and by the isomorphic group of deck transformations ,\\nacting on the universal cover . ( , ) are known\\nto be the binary icosahedral group and the sphere \\nrespectively.\\n Taking as the group manifold it is shown that\\n acts on by right multiplication.\\nA semidirect product group is constructed from as normal\\nsubgroup and from a second group which provides the icosahedral\\nsymmetries of . Based on F. Klein's fundamental icosahedral -invariant, we construct a novel hermitian -invariant\\npolynomial (generalized Casimir) operator . Its eigenstates with\\neigenvalues quantize a complete orthogonal basis on Poincar\\\\'{e}'s\\ndodecahedral 3-manifold. The eigenstates of lowest degree are 12\\npartners of Klein's invariant polynomial. The analysis has applications in\\ncosmic topology \\\\cite{LA},\\\\cite{LE}. If the Poincar\\\\'{e} 3-manifold is\\nassumed to model the space part of a cosmos, the observed temperature\\nfluctuations of the cosmic microwave background must admit an expansion in\\neigenstates of .\\n
Reliability of Data in Structured Peer-to-Peer Systems
2005-04-06

Peer-to-peer (P2P) systems are very useful for managing large amounts of widely distributed data. For this purpose distributed hash tables (DHT) offer a highly scalable and self-organizing paradigm for efficient distribution and retrieval of data. Thereby a common assumption of P2P systems is, that the participating nodes are unreliable and may fail at any time. Since many of research goes into the design of DHT lookup services, these systems aim to provide a stable global addressing structure. But to storage data reliable in a DHT only few techniques were already developed. However since data has to be stored persistent in the network, it should be retrieved anytime, even if nodes fail. In this work we discuss possibilities to store data fault tolerant in a structured peer-to-peer system.
A Design Environment for Processor-Like Reconfigurable Hardware
2005-04-06

There is a growing number of reconfigurable architectures that combine the advantages of a hardwired implementation (performance, power consumption) with the advantages of a software solution (flexibility, time to market). Today, there are devices on the market that can be dynamically reconfigured at run-time within one clock cycle. But the benefits of these architectures can only be utilized if applications can be mapped efficiently. In this paper we describe a design environment that takes into account the three aspects architecture, compiler, and applications, and we present the basic techniques that we use to realize the compiler.
Sterile neutrinos in neutrinoless double beta decay
2005-04-07

We study possible contribution of the Majorana neutrino mass eigenstate\\n dominated by a sterile neutrino component to neutrinoless double beta\\n( ) decay. From the current experimental lower bound on the\\n -decay half-life of Ge we derive stringent constraints\\non the mixing in a wide region of the values of mass. We\\ndiscuss cosmological and astrophysical status of in this mass region.\\n
TWO-PION PRODUCTION, γγ LINE AND ASPECTS OF σ MESON, BOSE–EINSTEIN CORRELATIONS AND ISOSPIN BREAKING
2005-04-10

The pp→ppx(x=γγ, π 0 π 0 , π + π - ) reactions have been measured at CELSIUS in the energy range T p =775-1360 MeV using the WASA 4π detector with hydrogen pellet target. Close to threshold the ppπ + π - data are in accordance with the Roper resonance concept and/or a dynamic formation of the σ meson. At higher energies the formation of the ΔΔ system becomes increasingly dominant. The ppπ 0 π 0 channel basically shows similar features, however, develops a peculiar enhancement at small invariant masses M π 0 π 0 - in resemblance of Bose-Einstein correlations. Alternatively, the enhancement could be also indicative of a (dynamic) isospin breaking due to ππ rescattering in the σ channel. The latter is favored by the results on pd→ 3 He x (x=π 0 π 0 , π + π - ), where the observed π 0 π 0 enhancements are still much larger. In the γγ channel a line at M γγ =2m π is observed. The possible nature of this line is discussed.
PION-NUCLEON SCATTERING EXPERIMENTS AT LOW ENERGIES: π-p→π0n TOTAL CROSS SECTIONS
2005-04-10

Total cross sections of the single charge exchange reaction π - p→π 0 n have been measured at PSI from about 40 to 250 MeV using a transmission technique. Preliminary results show an excellent agreement with predictions from the SAID FA02 phase shift analysis for energies above 70 MeV.
Line identification in soft X-ray spectra of stellar coronae by comparison with the hottest white dwarf's photosphere: Procyon, α Cen A+B, and H 1504+65
2005-04-11

H1504+65 is a young white dwarf with an effective temperature of 200,000 K and is the hottest post-AGB star ever analysed with detailed model atmospheres. Chandra LETG+HRC-S spectra have revealed the richest X-ray absorption line spectrum recorded from a stellar photosphere to date. The line forming regions in this extremely hot photosphere produce many transitions in absorption that are also observed in emission in cool star coronae. We have performed a detailed comparison of Chandra spectra of H1504+65 with those of Procyon and alpha Cen A and B. State of the art non-LTE model spectra for the hot white dwarf have enabled us to identify a wealth of absorption lines from highly ionized O, Ne and Mg. In turn, these features have allowed us to identify coronal lines whose origins were hitherto unknown.
Assessment of cognitive function and communication ability in a completely locked-in patient
2005-04-12

The term “locked in” refers to a paralysis of voluntary muscular functions1 as a consequence of disease that leads to de-efferentation of the motor system. Although blinking and vertical eye movements are sometimes preserved, many patients such as those with advanced ALS may lose all voluntary muscular function. We report a 58-year-old patient who had ALS for 8 years, who was artificially fed and respirated and had lost all motor control 8 months before the assessment. Both peripheral (electromyogram, heart rate, electro-oculogram [EOG], skin conductance level [SCL]) and central (EEG) functions were tested to determine if there might be a possibility to use other means than the striate muscular system for communication purposes. Moreover, it was not clear to what extent the patient was still cognitively intact and might be able to learn to communicate via an EEG-based brain-computer interface (BCI).2–4 Indications about cognitive awareness can be derived from psychophysiologic event-related paradigms using the EEG5,6 or other measures. We found that the patient was unable to use any muscle, not even the anal sphincter ...
Lexical postcorrection of OCR-results:the web as a dynamic secondary dictionary?
2005-04-12

Postcorrection of OCR-results for text documents is usuallybased on electronic dictionaries. When scanning textsfrom a specific thematic area, conventional dictionaries oftenmiss a considerable number of tokens. Furthermore,if word frequencies are stored with the entries, these frequencieswill not properly reflect the frequencies found inthe given thematic area. Correction adequacy suffers fromthese two shortcomings. We report on a series of experimentswhere we compare (1) the use of fixed, static large-scaledictionaries (including proper names and abbreviations)with (2) the use of dynamic dictionaries retrieved viaan automated analysis of the vocabulary of web pages froma given domain, and (3) the use of mixed dictionaries. Ourexperiments, which address English and German documentcollections from a variety of fields, show that dynamic dictionariesof the above mentioned form can improve the coveragefor the given thematic area in a significant way andhelp to improve the quality of lexical postcorrection methods.
Algebraic stability analysis of constraint propagation
2005-04-12

The divergence of the constraint quantities is a major problem in computational gravity today. Apparently, there are two sources for constraint violations. The use of boundary conditions which are not compatible with the constraint equations inadvertently leads to 'constraint violating modes' propagating into the computational domain from the boundary. The other source for constraint violation is intrinsic. It is already present in the initial value problem, i.e. even when no boundary conditions have to be specified. Its origin is due to the instability of the constraint surface in the phase space of initial conditions for the time evolution equations. In this paper, we present a technique to study in detail how this instability depends on gauge parameters. We demonstrate this for the influence of the choice of the time foliation in context of the Weyl system. This system is the essential hyperbolic part in various formulations of the Einstein equations.
Curved reformations using the medical imaging interaction toolkit (MITK)
2005-04-12

Modern systems for visualization, image guided procedures and display allow not only one type of visualization, but a variety of different visualization options. Only a combination of two-dimensional image display and three-dimensional rendering provides enough information for many tasks. Multiplanar orthogonal and oblique reformations of image data are standard features of medical imaging software packages today. Additionally, curved reformations are useful. For example, diagnosis of stenotic vessels can be supported by curved reformations along the centerline of the vessel, showing the complete vessel in one two-dimensional view. In this paper, we present how the open-source Medical Imaging Interaction Toolkit (MITK, www.mitk.org), which is based on the Insight Toolkit (ITK) and the Visualization Toolkit (VTK), can be used to rapidly build interactive systems that provide curved reformations. MITK supports curved reformations not only for images, but also for other data types (e.g., surfaces). Besides visualizations of curved reformations, which can be combined and are kept consistent with other two- and three-dimensional views of the data, interactions on such non-planar manifolds are supported. The developer only has to define the curved manifold, everything else is dealt with by the toolkit. We demonstrate these capabilities by means of a tool for mapping of coronary vessel trees.
A vector of high‐temperature paleo‐fluid flow deduced from mass transfer across permeability barriers (quartz veins)
2005-04-13

Abstract Quartz veins acted as impermeable barriers to regional fluid flow and not as fluid‐flow conduits in Mesoproterozoic rocks of the Mt Painter Block, South Australia. Systematically distributed asymmetric alteration selvedges consisting of a muscovite‐rich zone paired with a biotite‐rich zone are centered on quartz veins in quartz–muscovite–biotite schist. Geometric analysis of the orientation and facing of 126 veins at Nooldoonooldoona Waterhole reveals a single direction along which a maximum of all veins have a muscovite‐rich side, irrespective of their specific individual orientation. This direction represents a Mesoproterozoic fluid‐flow vector and the veins represent permeability barriers to the flow. The pale muscovite‐rich zones formed on the downstream side of the vein and the dark biotite‐rich zones mark the upstream side. The alteration couplets formed from mica schist at constant Zr, Ga, Sc, and involved increases in Si, Na, Al and decreases in K, Fe, Mg for pale alteration zones, and inverse alteration within dark zones. The asymmetry of the alteration couplets is best explained by the pressure dependence of mineral–fluid equilibria. These equilibria, in combination with a Darcian flow model for coupled advection and diffusion, and with permeability barriers imposed by the quartz veins, simulate the pattern of both fluid flow and differential, asymmetric metasomatism. The determined vector of fluid flow lies along the regional foliation and is consistent with the known distribution of regional alteration products. The presence of asymmetric alteration zones in rock containing abundant pre‐alteration veins suggests that vein‐rich material may have generally retarded regional fluid flow.
Peptide microarrays for the detection of molecular interactions in cellular signal transduction
2005-04-14

Abstract The formation of protein complexes is a hallmark of cellular signal transduction. Here, we show that peptide microarrays provide a robust and quantitative means to detect signalling‐dependent changes of molecular interactions. Recruitment of a protein into a complex upon stimulation of a cell leads to the masking of an otherwise exposed binding site. In cell lysates this masking can be detected by reduced binding to a microarray carrying a peptide that corresponds to the binding motif of the respective interaction domain. The method is exemplified for the lymphocyte‐specific tyrosine kinase 70 kDa zeta‐associated protein binding to a bis‐phosphotyrosine‐motif of the activated T‐cell receptor via its tandem SH2 domain. Compared to established techniques, the method provides a significant shortcut to the detection of molecular interactions.