julilili42/papers huggingface dataset:
U-Pb zircon SHRIMP ages, geochemical and Sr-Nd isotopic compositions of the Early Cretaceous I-type Sarıosman pluton, Eastern Pontides, NE Turkey
2009-01-01

The petrogenesis and U-Pb SHRIMP zircon ages of the Late Cretaceous Sarıosman pluton in the Eastern Pontides is investigated by means of whole-rock Sr-Nd isotope data with field, petrographic and whole-rock geochemical studies. The bulk of the I-type Sarıosman pluton consists of biotite-hornblende monzogranite, with minor quantities of porphyritic hornblende-biotite monzogranite. The biotite-hornblende monzogranite contains a number of mafic microgranular enclaves (MMEs) of quartz monzodiorite composition. U-Pb zircon sensitive high-resolution ion microprobe dating (SHRIMP) dates the magma emplacement age of the biotite-hornblende monzogranite at 82.7±1.5 Ma. The rocks of the pluton show high-K calc-alkaline, metaluminous to slightly peraluminous characteristics, and are enriched in large ion lithophile elements (LILE) and light rare earth elements (LREE) relative to high field strength elements (HFSE), thus displaying features of arc-related granitoids. Chondrite-normalised rare earth-element (REE) patterns have concave upward shapes (La/_{cn}/Lu_{cn}= 10.1-17.4) with pronounced negative Eu anomalies (Eu/Eu*= 0.61-0.80). Initial \\epsilon_{Nd} values vary between -3.0 and -4.1 and initial ^{87}Sr/^{86}Sr values between 0.7062 and 0.707. The MMEs are characterised by higher Mg-numbers (27-29) and lower values of both SiO_2 (56-58 wt percent) and aluminium saturation index (0.9-1.0), compared to the monzogranites. Fractionation of plagioclase, hornblende and Fe-Ti oxides played an important role in the evolution of the Sarıosman pluton. The crystallisation temperatures of the melts ranged from 700 to 800 °C and a relatively shallow intrusion depth (~2 to 7 km) is estimated from the Al-in-hornblende geobarometry. The geochemical and isotopic compositions of the Sarıosman pluton suggest an origin through dehydration melting of mafic lower crustal source rocks.
Generosity, Greed and Gambling: What difference does asymmetric information in bargaining make?
2009-01-01

We analyze the effects of asymmetric information concerning the size of a pie on proposer behavior in three different bargaining situations: the ultimatum game, the Yes-No-game and the dictator game. Our data show that (a) irrespective of the information condition, proposer generosity increases with responder veto power, (b) informed proposers in the ultimatum game try to exploit their superior information and hide their greed by a seemingly fair offer, and (c) uninformed proposers in the dictator game exhibit gambling behavior by asking for more than potentially is at stake. While the results of our experimental analysis are interesting as such, they may also yield interesting practical implications.
Prenatal Diagnosis and Management of a Fetal Intra-Abdominal Teratoma: A Case Report and Review of the Literature
2009-01-01

We report on a case of a large intra-abdominal teratoma diagnosed antenatally and managed successfully after birth. Intra-abdominal teratomas are rare in prenatal life. Ultrasound examination shows a heterogenic tumor with cystic and solid components. After postpartum surgical removal, the prognosis is generally good.
WSO-UV—Ultraviolet Mission for the Next Decade
2009-01-01

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Klaus Werner, Boris Shustov, Mikhail Sachkov, Ana I. Gómez de Castro, Maohai Huang, Norbert Kappelmann, Gang Zhao; WSO‐UV—Ultraviolet Mission for the Next Decade. AIP Conf. Proc. 24 May 2009; 1135 (1): 314–317. https://doi.org/10.1063/1.3154071 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Incomplete dissociation of glibenclamide from wild‐type and mutant pancreatic KATPchannels limits their recovery from inhibition
2009-01-01

Background and purpose: The antidiabetic sulphonylurea, glibenclamide, acts by inhibiting the pancreatic ATP‐sensitive K + (K ATP ) channel, a tetradimeric complex of K IR 6.2 and sulphonylurea receptor 1 (K IR 6.2/SUR1) 4 . At room temperature, recovery of channel activity following washout of glibenclamide is very slow and cannot be measured. This study investigates the relation between the recovery of channel activity from glibenclamide inhibition and the dissociation rate of [ 3 H]‐glibenclamide from the channel at 37°C. Experimental approach: K IR 6.2, K IR 6.2ΔN5 or K IR 6.2ΔN10 (the latter lacking amino‐terminal residues 2–5 or 2–10 respectively) were coexpressed with SUR1 in HEK cells. Dissociation of [ 3 H]‐glibenclamide from the channel and recovery of channel activity from glibenclamide inhibition were determined at 37°C. Key results: The dissociation kinetics of [ 3 H]‐glibenclamide from the wild‐type channel followed an exponential decay with a dissociation half‐time, t 1/2 (D) = 14 min; however, only limited and slow recovery of channel activity was observed. t 1/2 (D) for K IR 6.2ΔN5/SUR1 channels was 5.3 min and recovery of channel activity exhibited a sluggish sigmoidal time course with a half‐time, t 1/2 (R) = 12 min. t 1/2 (D) for the ΔN10 channel was 2.3 min; recovery kinetics were again sigmoidal with t 1/2 (R) ∼4 min. Conclusions and implications: The dissociation of glibenclamide from the truncated channels is the rate‐limiting step of channel recovery. The sigmoidal recovery kinetics are in quantitative agreement with a model where glibenclamide must dissociate from all four (or at least three) sites before the channel reopens. It is argued that these conclusions hold also for the wild‐type (pancreatic) K ATP channel.
Synthesis, Structure and Reactions of 1,3-Dimethyl-5-bis(thiomethyl)methylenebarbituric Acid
2009-01-01

1,3-Dimethyl-5-bis(thiomethyl)methylenebarbituric acid (8) is obtained from 1,3-dimethylbarbituric acid and CS 2 /NEt 3 followed by alkylation with methyl iodide. Compound 8 reacts with aqueous ammonia to give 5-amino(thiomethyl)methylene-1,3-dimethylbarbituric acid (9). With benzylamine, the thiomethyl substituent in 9 is replaced to give 5-amino(benzylamino)methylene-1,3- dimethylbarbituric acid (10) while with methanesulfonic acid the sulfonate salt 11 is formed. The crystal structures of 8 and 9 are reported.
Large-Scale Co-Phylogenetic Analysis on the Grid
2009-01-01

Phylogenetic data analysis represents an extremely compute-intensive area of Bioinformatics and thus requires high-performance technologies. Another compute- and memory-intensive problem is that of hostparasite co-phylogenetic analysis: given two phylogenetic trees, one for the hosts (e.g., mammals) and one for their respective parasites (e.g., lice) the question arises whether host and parasite trees are more similar to each other than expected by chance alone. CopyCat is an easy-to-use tool that allows biologists to conduct such co-phylogenetic studies within an elaborate statistical framework based on the highly optimized sequential and parallel A xParafit program. We have developed enhanced versions of these tools that efficiently exploit a Grid environment and therefore facilitate large-scale data analyses. Furthermore, we developed a freely accessible client tool that provides co-phylogenetic analysis capabilities. Since the computational bulk of the problem is embarrassingly parallel, it fits well to a computational Grid and reduces the response time of large scale analyses.
Managing Proof Documents for Asynchronous Processing
2009-01-01

Asynchronous proof processing is a recent approach at improving the usability and performance of interactive theorem provers. It builds on a simple metaphor: the user edits a proof document while the prover checks its consistency in the background without explicit requests from the user. This paper presents a software architecture for asynchronous proof processing. Its foundation is a novel state model for commands that synchronizes the possibly parallel accesses of the user interface and prover. The state model is complemented by a communication protocol that places minimal requirements on the prover. The model also allows asynchronous processing to be emulated by existing linear-processing proof engines, such that the migration to the new communication protocol is simplified. A prototype implementation that works with the current development version of Isabelle is presented.
Symmetric and asymmetric quasifission modes in reactions with heavy ions
2009-01-01

Mass and energy distributions of fission and quasifission fragments in the reactions 22Ne+249Cf, 26Mg+248Cm, 36S+238U and 58Fe+208Pb leading to the formation of the Z = 108 composite nucleus are reported. In this series of experiments it is shown for the first time that the quasifission process leads to the formation of not only asymmetric fragments but also gives a contribution to the symmetric mass region of fission fragments, most probably caused by the influence of nuclear shells with Z = 50 and N = 82.
An Earley parsing algorithm for range concatenation grammars
2009-01-01

We present a CYK and an Earley-style algorithm for parsing Range Concatenation Grammar (RCG), using the deductive parsing framework. The characteristic property of the Earley parser is that we use a technique of range boundary constraint propagation to compute the yields of non-terminals as late as possible. Experiments show that, compared to previous approaches, the constraint propagation helps to considerably decrease the number of items in the chart.
Toxic Dermatolysis, Tissue Necrosis and Impaired Wound Healing due to Sunitinib Treatment Leading to Forefoot Amputation
2009-01-01

Innovative treatment strategies in urologic oncology confront the treating physician with a new spectrum of adverse events. With growing understanding of underlying pathomechanisms, we need to identify contraindications against the use of certain antiproliferative drugs. The management of toxicities involves a multidisciplinary approach and thus, the exchange of experience across medical specialties is mandatory. We report a case of fulminant toxic dermatolysis, tissue necrosis and impaired wound healing resulting in the amputation of one forefoot after 6 days of treatment with sunitinib.
Induced Miscarriage in Early Mālikī and Hanafī Fiqh
2009-01-01

Abstract This article traces the manner in which Mālikī and Hanafī jurists in the first six centuries AH arrived at their respective legal assessments of induced miscarriage. Each madhhab developed its own interpretation of embryogenesis, based on Q. 5:95 and Q. 65:4, and, therefore, its own distinctive position on induced miscarriage: The Mālikīs hold for legal relevance from the moment of conception, while the Hanafīs hold for legal relevance at a later stage of embryological development. This difference was also caused by different opinions on ways to legally establish that a miscarriage was induced. Finally, the question of ensoulment, which became widespread in Islamic legal reasoning on induced miscarriage only after the 2nd/8th century, was linked to the Hanafī position that induced miscarriage is not punishable until the 120th day following conception.
Visualization and Explanation of Payload-Based Anomaly Detection
2009-01-01

The threat posed by modern network attacks requires novel means for detection of intrusions, as regular signature-based systems fail to cope with the amount and diversity of attacks. Recently, several methods for detection of anomalies in network payloads have been proposed to counteract this threat and identify novel attacks during their initial propagation. However, intrusion detection systems must not only flag malicious events but also provide information needed for assessment of security incidents. Previous work on payload-based anomaly detection has largely ignored this need for explainable decisions. In this paper, we present instruments for visualization and explanation of anomaly detection which can guide the decisions of a security operator. In particular, we propose two techniques: feature differences, for identifying relevant string features of detected anomalies, and feature shading, for highlighting of anomalous contents in network payloads. Both techniques are empirically evaluated using real attacks and network traces, whereby their ability to emphasize typical patterns of attacks is demonstrated.
In vivo Activation of Tetracycline Rep ressor by Cre/<i>lox</i>-Mediated Gene Assembly
2009-01-01

Tetracycline repressor (TetR) bears an unstructured loop region between helices α8 and α9, which is moderately permissive to amino acid exchanges and length variations. Recognition sites for the site-specific recombinases Flp &lt;i&gt;(FRT)&lt;/i&gt; or Cre &lt;i&gt;(lox)&lt;/i&gt; were inserted in-frame into &lt;i&gt;tetR&lt;/i&gt;, substituting some of this loop’s codons. A number of the deduced TetR variants displayed efficient regulation in vivo, thus allowing the establishment of a new mode of TetR activation on the genetic level. Chromosomally encoded &lt;i&gt;tetR&lt;/i&gt; in &lt;i&gt;Bacillus subtilis&lt;/i&gt; was disrupted and inactivated by insertion of a &lt;i&gt;lox66&lt;/i&gt;-&lt;i&gt;aphAIII&lt;/i&gt;-&lt;i&gt;lox71&lt;/i&gt; kanamycin resistance cassette. Marker excision by Cre recombinase led to the assembly of a novel &lt;i&gt;tetR&lt;/i&gt; allele. The encoded regulator, termed TetR&lt;sup&gt;lox72/1&lt;/sup&gt;, is distinguished from wt-TetR by a slightly elongated and altered α8–α9 loop only, harboring an amino acid stretch encoded by &lt;i&gt;lox72&lt;/i&gt;. Despite decreased intracellular protein amounts, TetR&lt;sup&gt;lox72/1&lt;/sup&gt; displayed efficient in vivo activity in &lt;i&gt;B. subtilis&lt;/i&gt; and &lt;i&gt;E. coli&lt;/i&gt;, indistinguishable from that of wt-TetR. These results underline the sequence flexibility of TetR in the α8-α9 loop and demonstrate the possible use of the regulator as a read-out tool for the activity of site-specific recombinases.
A technical framework to support implicit structured collaboration
2009-01-01

Verbal communication, particularly the ability to give directions and understand them, is a key not only for learning but also for every day life. Since one main objective of schools for pupils with cognitive disability or learning difficulties is to prepare pupils to manage their every day life on their own, we expect that teaching pupils how to learn and work collaboratively by sharing tasks, give directions to each other and understand them, will support this process and provide them in becoming more independent. In this paper we will present an environment which supports implicit scripted collaborative task solving without increasing cognitive load.
Inclusivism at Qumran
2009-01-01

Abstract Within Early Judaism the Qumran Community is widely perceived as a strictly exclusivist group. A thorough analysis of Qumran texts, however, reveals, apart from the dominant strand of exclusivism, remarkably clear inclusivist tendencies. In Qumran literature inclusivist tendencies can be seen both in eschatological texts and in materials dealing with the self-understanding of the Qumran Community in historical time. The legal texts discussed basically confirm this pattern: the Community is to separate from Gentiles and from members of those Jewish groups with whom it earlier entertained close relations. At the same time it is to support the poor and the proselytes. Strictly legal statements prohibiting contacts with non-Essene Judaism as such are missing. In the literature discussed inclusivist and exclusivist tendencies have diff erent weight. A pan-Israelite, e.g. inclusivist, perspective can be seen in 4QpNah, 4QFlor, 4QSM and especially in 4QMMT, 1QSa, and CD/4QD whereas in 1QS exclusivist tendencies predominate.
Knowledge Communication with Shared Databases
2009-01-01

Addressing knowledge communication with shared databases, this chapter focuses on an asynchronous, many-to-many type of computer-mediated communication (CMC). After an introduction, which characterizes this kind of CMC and provides definitions, various aspects are discussed that influence people’s behavior in knowledge communication with shared databases. This presentation focuses on psychological rather than on technological factors. The first aspect presented is the influence of anonymity and identifiability, followed by the impact of metaknowledge. Next, costs and bonus systems, and then feedback and guidelines are discussed. Other aspects which are considered are group size and participant personality. For each of these influencing factors, underlying theoretical approaches as well as empirical results are presented. Subsequently, these considerations and findings are examined with respect to their practical applications. In conclusion, future trends in database-oriented knowledge communication are discussed.
Measurements of Sound Localization Performance and Speech Quality in the Context of 3D Audio Conference Calls
2009-01-01

Teleconferencing solutions supporting 3D audio have two advantages. First, the talkers can be identified easily by locating their position in the virtual acoustic environment. Second, if multiple persons talk at the same time, humans can
Weathering of granite and granitic regolith in Corsica: short-term 10 Be versus long-term thermochronological constraints
2009-01-01

Abstract In situ 10 Be concentrations in granites on Corsica (Mediterranean), exposed to subalpine climate, yield weathering rates of between 9 and 20 mm ka −1 , when averaged over the last 30–100 ka. Weathering rates rise with increasing precipitation and brittle deformation. Thermal history modelling of apatite fission-track (AFT) data confirms that average denudation rates of 5–20 mm ka −1 were typical during the Neogene. Short- and long-term denudation rates are in the same range and indicate that a late Neogene global increase in denudation rates has probably not affected geomorphically stable uplifted palaeosurfaces of hilly to low mountainous local relief. A Southwards decrease in short- and long-term denudation rates indicate a linear relationship with decreasing precipitation. Post-glacial downwearing of moraine matrix, as constrained by soil-derived humic etching of dated glacial boulders, yields 40–140 mm ka −1 , which indicates a poor preservation potential of moraines older than the last glaciation. This weathering rate is of the order of 3 times faster than that found for long-term regolith formation from granites based on of geomorphic evidence.
Influence of controlled vascular training on the pain free walking distance and plasmaviscosity in patients suffering from peripheral arterial occlusive disease
2009-01-01

Does controlled vascular training influence plasmaviscosity and the pain free walking distance in patients with peripheral arterial occlusive disease (paod) Fontaine stage II?37 patients, 24 men and 13 women with a mean age of 64.5 years SD 8.5 took part in ambulant vascular training over a period of 12 months.Before, after 6 months and after 12 months, pain free (pfwd) and maximum walking distance (mwd) was measured using a standardized treadmill program. Also ankle-brachials systolic pressure index (a-bspi), transcutaneous oxygen tension (tcPO2) and plasmaviscosity (pv) were measured.Pfwd increased from 212 SD 143 m to 371 SD 249 m (p<0.02). TcPO2 increased during training, but without statistically significance. A-bspi increased between the first 6 months of training statistically significant. Before training pv was 1.31 mPa s SD 0.10, after training period of 6 months it was 1.27 mPa s SD 0.11 (p=0.06) and 12 months later it was 1.28 SD 0.11 mPa s (p=0.35). The improvement of pfwd and the decrease of pv correlates (r=-0.39, p=0.05).In most patients, arterial vascular training improves pfwd and mwd. Simultaneously to the increase of the walking distances plasmaviscosity decreases and crurobrachial indexes increases. We found a coupling between improvement of pfwd and pv. Pv seems to participate in improvement of leg hemodynamics in patients with paod.
A metering infrastructure for heterogenous mobile networks
2009-01-01

The next generation of mobile access networks will support different access technologies like UMTS, WLAN, WiMax and LTE. Optimal handover decisions between different access networks have to take various types of information into account, such as the load of possible target cells. However, collecting this information and transporting it to mobility management decision engines is costly in terms of bandwidth. With our flexible Generic Metering Infrastructure (GMI) we are able to collect state information from the core and access networks efficiently. Using the GMI, network operators will be able to control handover decisions for their users.
Persistence of isolated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse – a European pooled analysis.
2009-01-01

Abstract Abstract #304 Purpose:&amp;#x2028; The prognostic significance of DTC in the BM of breast cancer pts at the time of primary diagnosis has already been confirmed by a large pooled analysis. In view of the lack of early indicators for secondary adjuvant treatment, we here evaluated whether the persistence of DTC after adjuvant therapy confers a risk for relapse and breast cancer-related death.&amp;#x2028; Patients and Methods:&amp;#x2028; We analyzed BM aspirates of 723 pts from academic breast cancer units in Oslo (n=356), Munich (n=228) and Tuebingen (n=139) during recurrence-free follow-up at a mean interval of 31.7 months (standard deviation [std] 19.4 months) after primary diagnosis of breast cancer pT1-4, pN0-3 pM0. Carcinoma cells were detected using a standardized immunoassay with the monoclonal antibodies A45-B/B3 (Munich, Tuebingen), or AE1 and AE3 (Oslo), directed against cytokeratin (CK). Pts were followed for a median of 54.5 months (SD 25.1 months) after primary diagnosis.&amp;#x2028; Results:&amp;#x2028; Persistent DTC in the BM was detected in 15.5% of the pts (n=112). The Kaplan-Meier estimate for mean distant relapse-free survival was 162.5 months (157.9 – 167.0 95%CI) in pts with negative and 102.4 months (94.2 – 110.6, 95% CI, p&amp;lt; .0001, log rank test) in pts with positive BM status. The mean overall survival was 170.1 months, (167.7 – 172.5 95% CI), compared to 113.4 months in patients with persistent DTC in BM (107.3 – 119.5, p &amp;lt; .0001). In multivariate Cox regression analysis, allowing for BM status, tumor size, nodal status and histopathological grading, presence of DTC was an independent prognostic factor for reduced breast cancer specific survival ((RR 3.42, 1.64 – 7.13 95% CI, p= .001).&amp;#x2028; Conclusion:&amp;#x2028; Persistent DTC significantly predicts an increased risk for subsequent relapse, and, therefore, might serve as a potent monitoring tool for the follow-up of breast cancer pts. Future therapeutic intervention trials are currently being initiated to assess the benefit of secondary adjuvant treatment based on DTC detection as stratification parameter. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 304.
Synchronous rewriting in treebanks
2009-01-01

Several formalisms have been proposed for modeling trees with discontinuous phrases. Some of these formalisms allow for synchronous rewriting. However, it is unclear whether synchronous rewriting is a necessary feature. This is an important question, since synchronous rewriting greatly increases parsing complexity. We present a characterization of recursive synchronous rewriting in constituent tree-banks with discontinuous annotation. An empirical investigation reveals that synchronous rewriting is actually a necessary feature. Furthermore, we transfer this property to grammars extracted from tree-banks.