julilili42/papers huggingface dataset:
Mesozoic and Cenozoic Sequence Stratigraphy of European Basins: SEPM Special Publication Series no. 60
2000-08-01

Book Review| August 01, 2000 Mesozoic and Cenozoic Sequence Stratigraphy of European Basins: SEPM Special Publication Series No. 60 JÖRG PROSS JÖRG PROSS 1Institut und Museum für Geologie und Paläontologie, Sigwartstraβe 10, Universität Tübingen, D-72076 Tübingen GERMANY Search for other works by this author on: GSW Google Scholar Author and Article Information JÖRG PROSS 1Institut und Museum für Geologie und Paläontologie, Sigwartstraβe 10, Universität Tübingen, D-72076 Tübingen GERMANY Publisher: SEPM Society for Sedimentary Geology First Online: 03 Mar 2017 Online Issn: 1938-5323 Print Issn: 0883-1351 Society for Sedimentary Geology PALAIOS (2000) 15 (4): 363–364. https://doi.org/10.1669/0883-1351(2000)015<0363:BR>2.0.CO;2 Article history First Online: 03 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation JÖRG PROSS; Mesozoic and Cenozoic Sequence Stratigraphy of European Basins: SEPM Special Publication Series No. 60. PALAIOS 2000;; 15 (4): 363–364. doi: https://doi.org/10.1669/0883-1351(2000)015<0363:BR>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyPALAIOS Search Advanced Search Mesozoic and Cenozoic Sequence Stratigraphy of European Basins: SEPM Special Publication Series No. 60, P.C. de Graciansky, J. Hardenbol, T. Jaquin, and P.R. Vail (Editors), 1998, SEPM (Society for Sedimentary Geology), Tulsa, 786 p. ( 125 members) ISBN: 1-56576-043-3. From the mid-seventies, and especially since 1987 when Haq et al. proposed a chronostratigraphic record of Mesozoic and Cenozoic sequences, the paradigm of sequence stratigraphy has evolved as a sound building block in sedimentary geology. Among soft-rock geologists, the sequence stratigraphic premise that deposition within a basin is controlled by the principal variables of subsidence or uplift of the basin... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
New collective modes for a many-body system with proton-neutron pairing interaction
2000-08-03

A solvable Hamiltonian is treated within a time-dependent variational approach using four different variational states. One description is equivalent to the pnQRPA approach, while another one describes a new proton-neutron collective mode which is associated with a new phase of the nuclear system. The transition from one solution to the other is achieved through a Goldstone mode. For the quantized ground and first excited states the quasi-particle correlations, the Fermi β- and β+ transition amplitude and the Ikeda sum rule have been calculated. Two of the variational states are similar to the standard pnQRPA vacuum and are used to calculate the second excited states.
The First Low Molecular Weight Antibiotic from Lactic Acid Bacteria: Reutericyclin, a New Tetramic Acid
2000-08-04

The first chemical proof is available to show that lactic acid bacteria, generally known for their limited metabolite spectrum, are able to produce antibiotics with a broad inhibitory spectrum. The new tetramic acid, reutericyclin (1), opens a new dimension in the discussion regarding the application of lactic acid bacteria in food preservation or for positively influencing the human intestinal microflora.
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
2000-08-09

Transport of lactate and other monocarboxylates in mammalian cells is mediated by a family of transporters, designated monocarboxylate transporters (MCTs). The MCT4 member of this family has recently been identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes [Wilson, Jackson, Heddle, Price, Pilegaard, Juel, Bonen, Montgomery, Hutter and Halestrap (1998) J. Biol. Chem. 273, 15920–15926]. To analyse the functional properties of this transporter, rat MCT4 was expressed in Xenopus laevis oocytes and transport activity was monitored by flux measurements with radioactive tracers and by changes of the cytosolic pH using pH-sensitive microelectrodes. Similar to other members of this family, monocarboxylate transport via MCT4 is accompanied by the transport of H+ across the plasma membrane. Uptake of lactate strongly increased with decreasing extracellular pH, which resulted from a concomitant drop in the Km value. MCT4 could be distinguished from the other isoforms mainly in two respects. First, MCT4 is a low-affinity MCT: for l-lactate Km values of 17±3mM (pH-electrode) and 34±5mM (flux measurements with l-[U-14C]lactate) were determined. Secondly, lactate is the preferred substrate of MCT4. Km values of other monocarboxylates were either similar to the Km value for lactate (pyruvate, 2-oxoisohexanoate, 2-oxoisopentanoate, acetoacetate) or displayed much lower affinity for the transporter (β-hydroxybutyrate and short-chain fatty acids). Under physiological conditions, rat MCT will therefore preferentially transport lactate. Monocarboxylate transport via MCT4 could be competitively inhibited by α-cyano-4-hydroxycinnamate, phloretin and partly by 4,4 ́-di-isothiocyanostilbene-2,2 ́-disulphonic acid. Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
2000-08-15

Transport of lactate and other monocarboxylates in mammalian cells is mediated by a family of transporters, designated monocarboxylate transporters (MCTs). The MCT4 member of this family has recently been identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes [Wilson, Jackson, Heddle, Price, Pilegaard, Juel, Bonen, Montgomery, Hutter and Halestrap (1998) J. Biol. Chem. 273, 15920-15926]. To analyse the functional properties of this transporter, rat MCT4 was expressed in Xenopus laevis oocytes and transport activity was monitored by flux measurements with radioactive tracers and by changes of the cytosolic pH using pH-sensitive microelectrodes. Similar to other members of this family, monocarboxylate transport via MCT4 is accompanied by the transport of H+ across the plasma membrane. Uptake Of lactate strongly increased with decreasing extracellular pH, which resulted from a concomitant drop in the K(m) value. MCT4 could be distinguished from the other isoforms mainly in two respects. First, MCT4 is a low-affinity MCT: for L-lactate K(m) values of 17 ± 3 mM (pH-electrode) and 34 ± 5 mM (flux measurements with L-[U-14C]lactate) were determined. Secondly, lactate is the preferred substrate of MCT4. K(m) values of other monocarboxylates were either similar to the K(m) value for lactate (pyruvate, 2-oxoisohexanoate, 2-oxoisopentanoate, aceto-acetate) or displayed much lower affinity for the transporter (β-hydroxybutyrate and short-chain fatty acids). Under physiological conditions, rat MCT will therefore preferentially transport lactate. Monocarboxylate transport via MCT4 could be competitively inhibited by α-cyano-4-hydroxycinnamate, phloretin and partly by 4,4'-di-isothiocyanostilbene-2,2'-disulphonic acid. Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuri-benzoesulphonic acid.
Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells.
2000-08-15

Interleukin (IL)-10 secretion by tumor cells was demonstrated to be one of the mechanisms by which tumor cells can escape immunological recognition and destruction. In dendritic cells (DCs), which are currently used for vaccination therapies for malignant diseases, IL-10 inhibits IL-12 production and induces a state of antigen-specific anergy in CD4- and CD8-positive T cells. We therefore analyzed the effects of different activation stimuli including lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, and CD40 ligation on IL-10 mediated inhibition of DC development and stimulatory capacity. In our study, the addition of IL-10 to the cultures containing granulocyte/macrophage-colony stimulating factor and IL-4 with or without LPS completely inhibited the generation of DCs from peripheral blood monocytes. These cells remained CD14 positive and expressed high levels of IL-10 receptor (IL-10R), suggesting that IL-10 mediates its effects by up-regulating the IL-10R. In contrast, the simultaneous incubation of monocytes with IL-10 and TNF-alpha or soluble CD40 ligand (sCD40L) resulted in the generation of CD83-positive DCs, induction of nuclear localized RelB, and inhibition of IL-10R up-regulation. DCs grown in the presence of IL-10 and TNF-alpha or sCD40L elicited efficient CTL responses against viral and tumor-associated peptide antigens, which, however, were reduced as compared with DC cultures generated without IL-10. IL-10 decreased the production of IL-6 and the expression of IL-12 in the presence of TNF-alpha or sCD40L, but it had no effect on IL-15, IL-18, and TNF-alpha secretion. Our results show that TNF-alpha or CD40 ligation can antagonize the IL-10-mediated inhibition on DC function, suggesting that depending on activation stimuli, the presence of IL-10 does not necessarily result in T-cell anergy.
Efficient Lytic Infection of Human Arterial Endothelial Cells by Human Cytomegalovirus Strains
2000-08-15

ABSTRACT Endothelial cells (EC) are common targets of permissive infection by human cytomegalovirus (HCMV) in vivo during acute disease. However, studies of HCMV-EC interactions in vitro have generated discordant results. While lytic infection of cultured venous EC has been well established, Fish et al. (K. N. Fish, C. Soderberg Naucler, L. K. Mills, S. Stenglein, and J. A. Nelson, J. Virol. 72:5661–5668) have reported noncytopathic persistence of the virus in cultured aortic EC. We propose that interstrain differences in viral host cell tropism rather than the vascular bed of origin of infected EC might account for these discrepancies. In the present investigation we compared the responses of EC derived from human adult iliac artery, placental microvasculature, and umbilical vein to infection with various HCMV strains. Regardless of the vascular bed of origin, infection with EC-propagated HCMV strains induced 100% efficient cytopathic change progressing to complete lysis of inoculated monolayers. While fibroblast-propagated strains persisted at low titer in infected arterial EC cultures, they were also cytolytic for individual infected cells. The finding of cytopathic lytic infection of arterial EC by HCMV implicates a mechanism of vascular injury in the pathogenesis of HCMV infection.
Genetic Engineering on Shikonin Biosynthesis: Expression of the Bacterial ubiA Gene in Lithospermum erythrorhizon
2000-08-15

The naphthoquinone pigment shikonin from Lithospermum erythrorhizon Sieb. et Zucc. (Boraginaceae) was the first plant secondary metabolite produced in industrial scale from plant cell cultures. We have now manipulated the biosynthetic pathway leading to shikonin in L. erythrorhizon by introduction of the bacterial gene ubiA. This gene of Escherichia coli encodes 4-hydroxybenzoate-3-polyprenyltransferase, a membrane-bound enzyme that catalyzes a key step in ubiquinone biosynthesis. Using geranyl diphosphate (GPP) as substrate, it is able to catalyze the formation of 3-geranyl-4-hydroxybenzoate (GBA), a principal step of shikonin biosynthesis. The prokaryotic ubiA gene was fused to two signal sequences for targeting of the resulting peptide to the endoplasmic reticulum (ER). Constructs with different constitutive promoters were introduced into L. erythrorhizon using Agrobacterium rhizogenes-mediated transformation. In the resulting hairy root lines, high UbiA enzyme activities could be observed, reaching 133 pkat mg(-1). Expression of ubiA resulted in an accumulation of GBA in an amount exceeding that of the control culture by a factor of 50. However, the ubiA-transformed lines showed only a marginal (average 22%) increase of shikonin production in comparison to the control lines, and there was no significant correlation of UbiA enzyme activity and shikonin accumulation. This suggests that overexpression of ubiA alone is not sufficient to increase shikonin formation, and that further enzymes are involved in the regulation of this pathway.
Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production
2000-08-15

Abstract IL-6 is synthesized in human pampilloma virus (HPV)-transformed cervical carcinoma cell lines and is supposed to stimulate these cells in an autocrine manner. We studied IL-6 production and responsiveness in nonmalignant HPV-transformed keratinocytes and cervical carcinoma cells in detail. IL-6 was detected in cervical carcinomas in situ. Correspondingly, HPV-positive carcinoma cell lines expressed high IL-6 levels. However, these carcinoma cell lines showed low responsiveness to IL-6 as revealed by low constitutive STAT3 binding activity, which was not further enhanced by exogenous IL-6. In contrast, in vitro-transformed nonmalignant keratinocytes without endogenous IL-6 production strongly responded to exogenous IL-6 with activation of STAT3. STAT3 protein expression levels were comparable in both responsive and nonresponsive cell lines. Also, gp130, the upstream signal-transducing receptor subunit conveying IL-6 signals into the cell, was expressed in all tested cell lines. However, the IL-6 binding subunit gp80 was lost in the malignant cells. Addition of soluble gp80 was sufficient to restore IL-6 responsiveness in carcinoma cells as shown by enhanced activation of STAT3 binding activity. As a consequence of the restored IL-6 responsiveness, carcinoma cells strongly produced the chemokine monocyte chemoattractant protein-1 (MCP-1). Our data demonstrate that cervical carcinoma cells producing high amounts of IL-6 only weakly respond to IL-6 in an autocrine manner due to limited gp80 expression. While production of IL-6 might contribute to a local immunosuppressive effect, silencing an autocrine IL-6 response prevents constitutive production of the mononuclear cell-attracting chemokine MCP-1. Both mechanisms might help the tumor to escape the immune system.
ChemInform Abstract: X‐Ray Structures and ab initio Study of the Conformational Properties of Novel Oxazole and Thiazole Containing Di‐ and Tripeptide Mimetics (I), (II).
2000-08-15

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hyperthermia enhanced chemosensitivity of human malignant glioma cells.
2000-08-17

In an effort to overcome chemoresistance of human malignant glioma cells, the modulation of drug-induced cell death by hyperthermia was assessed in 4 human malignant glioma cells lines, LN-18, LN-229, T98G and U87MG. Compared to normothermic conditions, pulsed 24 h drug exposure enhanced the sensitivity of glioma cells most strikingly with teniposide, treosulfan, topotecan and cisplatin, moderately with vincristine, CCNU and doxorubicin, but not with gemcitabine. Susceptibility to hyperthermia-mediated drug sensitization, varied significantly with T98G and LN-229 being strongly sensitized and U87MG being most resistant to the effects of hyperthermia. Hyperthermia did not significantly modulate drug-induced changes in cell cycle distribution. The degree of sensitization was independent of p53 status and of multidrug resistance (mdr) activity. Hyperthermia may thus be a useful approach to overcome, chemoresistance of human malignant glioma cells.
Soluble levels of CD-95, CD 95-L and various cytokines after exposing human leukocytes to ionizing radiation.
2000-08-17

Local radiation induced a significant systemic decrease of all lymphocyte subsets, but neither a systemic release of cell death mediators like CD95 or various cytokines, nor a release in the extracellular space in vitro were detectable.
Pronounced Steric Hindrance for Nitrogen Inversion in 1,3,4-Oxadiazolidines
2000-08-18

Very high inversion barriers for a pyramidal nitrogen atom have been found for the sterically hindered 1,2,4-oxadiazolidines 1 (R1, R2=CH3) and 2 (R1=COOCH3, R2=CH2CH3, only one enantiomer is shown). The synthesis and NMR studies of the diastereomerization of 2 are described, as well as the determination of the enantiomerization barrier of 1 by stopped-flow multidimensional gas chromatography (sfMDGC).
Automatic generation of local internet catalogues using hierarchical Radius-based competitive learning
2000-08-20

This work presents a way to cluster HTML document sets in an hierarchical manner. The hierarchical clustering is performed using the Hierarchical Radius-based Competitive Learning (HRCL) neural network that has been developed by the authors. After a detailed discussion of the algorithm, HRCL clustering as well as retrieval results will be presented. The HRCL clustering results in a hierarchical multi-resolution view of the underlying (local) HTML data collection, consisting of clusters (with its cluster centroids), sub-clusters, sub-subclusters and so forth. The results can be combined and rendered in the way of an Internet catalogue resembling the known Yahoo directory. The Internet search can finally be accelerated using the automatically generated (sub-)cluster centroids.
ChemInform Abstract: Techview: Drug Discovery. Integrating Combinatorial Synthesis and Bioassays
2000-08-22

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Conformal Infinity
2000-08-23

The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, "conformal infinity" is related with almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved out of physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation and how it lends itself very naturally to solve radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.
Axial vector current in an electromagnetic field and low-energy neutrino-photon interactions
2000-08-23

An expression for the axial vector current in a strong, slowly varying\\nelectromagnetic field is obtained. We apply this expression to the construction\\nof the effective action for low-energy neutrino-photon interactions.\\n
Enriching a lexical semantic net with selectional preferences by means of statistical corpus analysis
2000-08-25

. Broad-coverage ontologies which represent lexical semantic knowledge are being built for more and more natural languages. Such resources provide very useful information for word sense disambiguation, which is crucial for a variety of NLP tasks (e.g. semantic annotation of corpora, information retrieval, or semantic inferencing). Since the manual encoding of such ontologies is very labour-intensive, the development of (semi-)automatic methods for acquiring lexical semantic information is an important task. This paper addresses the automatic acquisition of selectional preferences of verbs by means of statistical corpus analysis. Knowledge about such preferences is essential for inducing thematic relations, which link verbal concepts to nominal concepts that are selectionally preferred as their complements. Several approaches for learning selectional preferences from corpora have been proposed in the last years. However, their usefulness for ontology building is limited. This paper intr...
ChemInform Abstract: 2‐Seleno‐ and 2‐Telluroimidazolines: Syntheses, Structures and Properties
2000-08-29

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21
2000-09-01

Achromatopsia is an autosomal recessive disorder featuring total colour blindness, photophobia, reduced visual acuity and nystagmus. While mutations in the CNGA3 gene on chromosome 2q11 are responsible for achromatopsia in a subset of patients, previous linkage studies have localized another achromatopsia locus, ACHM3, on chromosome 8q21. Using achromatopsia families in which CNGA3 mutations have been excluded, we refined the ACHM3 locus to a 3.7 cM region enclosed by markers D8S1838 and D8S273. Two yeast artificial chromosome (YAC) contigs covering nearly the entire ACHM3 interval were constructed. Database searches with YAC content sequences identified two overlapping high throughput genomic sequencing phase (HTGS) entries which contained sequences homologous to the murine cng6 gene encoding the putative beta-subunit of the cone photoreceptor cGMP-gated channel. Using RT-PCR and RACE, we identified and cloned the human cDNA homologue, designated CNGB3, which encodes an 809 amino acid polypeptide. Northern blot analysis revealed a major transcript of approximately 4.4 kb specifically expressed in the retina. The human CNGB3 gene consists of 18 exons distributed over approximately 200 kb of genomic sequence. Analysis of the CNGB3 gene in achromats revealed six different mutations including a missense mutation (S435F), two stop codon mutations (R203X and E336X), a 1 bp and an 8 bp deletion (1148delC and 819-826del) and a putative splice site mutation of intron 13. The 1148delC mutation was identified recurrently in several families, and in total was present on 11 of 22 disease chromosomes segregating in our families.