julilili42/papers huggingface dataset:
Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment
2019-06-05

Abstract INTRODUCTION Impaired long-term memory is a defining feature of Mild Cognitive Impairment (MCI). We tested whether this impairment is item-specific, limited to some memoranda whereas some remain consistently memorable. METHODS We conducted item-based analyses of long-term visual recognition memory. 394 participants (healthy controls (HC), Subjective Cognitive Decline (SCD), and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. RESULTS We observed consistent memorability for images in HCs, SCDs, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. DISCUSSION Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.
Does Bti (Bacillus thuringiensis var. israelensis) affect Rana temporaria tadpoles?
2019-06-05

Biocides based on toxins of Bacillus thuringiensis var. israelensis (Bti) are established as alternatives to conventional chemical insecticides for mosquito control all across the globe since they are regarded ecologically compatible and harmless to non-target species. Since recent studies on amphibian larvae have called this opinion into question, we exposed Rana temporaria tadpoles to single (1 mg/L), tenfold (10 mg/L) and hundredfold (100 mg/L) field concentrations of VectoBac<sup>®</sup> WG (a water dispersible granule Bti formulation) in the laboratory for eleven days to investigate whether larvae were adversely affected by Bti and its endotoxin proteins. In addition to a negative (water) control, a positive control based on organic rice protein (50 mg/L) was run to check for the nutritional relevance of Bti proteins. There was no Bti-related mortality and a histopathological analysis of tadpole intestines revealed no adverse effects. Analyses of biomarkers for proteotoxicity (stress protein family, Hsp70) and neurotoxicity or metabolic action (b-esterases acetylcholine esterase (AChE) and carboxylesterases) revealed no significant differences between Bti treatments and the negative control. The responses of tadpoles in the protein-supplemented positive control differed from those of the negative control and the Bti treatments. Tadpoles in the positive control had reduced body mass and elevated AChE activity.
Exercise therapy and physical activity promotion: do exercise therapists assess or receive information on clients’ relevant personal factors? A national survey from Germany
2019-06-05

<b>Background:</b> Physical activity promotion requires a multi-layered assessment that does not only assess body functions but which in particular also includes the measurement of personal factors (e.g. exercise self-efficacy). <b>Objectives:</b> The purpose was to review the utilisation of standardised measurements (SMs), admission interviews and interdisciplinary information sharing, and to analyse the content of these practices with respect to physical activity promotion. <b>Design:</b> Observational, cross-sectional national survey. <b>Method:</b> A Germany-wide, quantitative survey, collecting information from 713 exercise therapy departments, was conducted. Measurements were classified as standardised or non-standardised and assigned to the International Classification of Functioning (ICF). Admission interviews and information from other professionals were analysed using a qualitative content analysis. <b>Results:</b> In total, 1008 SMs included 9007 ICF concepts: 16% were classified as personal factors, but none were clearly related to physical activity promotion. Admission interviews contained several non-standardised assessments of personal factors: goals (40%), exercise experiences/activity bibliography (10%), activity level (5%), exercise preferences (2%). Information sharing does not contain relevant information for physical activity promotion. <b>Discussion:</b> Exercise therapists have scant information about the personal factors that influence clients’ physical activity behaviour. An assessment for physical activity promotion that includes physical functioning and personal factors has, so far, barely been implemented in practice.
Looking Through “Rose-Tinted” Glasses: The Influence of Tint on Visual Affective Processing
2019-06-06

The use of color-tinted lenses can introduce profound effects into how we process visual information at the early to late stages. Besides mediating harsh lighting conditions, some evidence suggests that color-tinted lenses can influence how humans respond to emotional events. In this study, we systematically evaluated how color-tinted lenses modified our participants' psychophysiological responses to emotion-inducing images. The participants passively viewed pleasant, neutral or unpleasant images from the International-Affective-Picture-System (IAPS), while wearing none, blue, red, yellow or green tinted-lenses that were controlled for luminance. Established neuroergonomic indices of arousal were measured on the autonomic level, namely Skin-Conductance-Response (SCR) and Heart-Rate-Variability (HRV), and on the cortical level, with electroencephalography (EEG) event-related potentials (ERPs). Phasic SCR responses were significantly enhanced for unpleasant images and both pleasant and unpleasant images induced significantly larger ERP amplitudes of the Late-Positive-Potential (LPP), with pleasant images having the greatest impact. Interestingly, a significant main effect was found for tint. Similar to viewing pleasant images, red-tinted lenses induced the largest LPPs. Taken together, these findings suggest that the autonomic response to affective images is modulated at the cortical level of processing, congruent with the use of red-tinted lenses.
Combinatorial proteomics and transcriptomics identify AMPK in the control of the axonal regeneration programme of DRG sensory neurons after spinal injury
2019-06-06

SUMMARY Regeneration after injury occurs in axons that lie in the peripheral nervous system but it fails in the central nervous system limiting functional recovery. Despite recent progress, the signalling response to injury of peripheral versus central projecting axons that might underpin this differential regenerative ability is currently largely uncharacterized. To fill this knowledge gap, here we combined axoplasmic proteomics from peripheral sciatic or central projecting dorsal root axons from sciatic DRG neurons. Proteomics was combined with cell body RNAseq to compare axonal and soma responses between a spinal regeneration-incompetent versus sciatic regeneration-competent nerve injury. This allowed the identification of injury-dependent signalling pathways uniquely represented in peripheral versus central projecting sciatic DRG axons. RNAseq and proteomics analysis suggested AMPK as a putative regulator of axonal regenerative signalling pathways. AMPK immunoprecipitation followed by mass spectrometry from DRG suggested that the 26S proteasome and its regulatory subunit PSMC5 preferentially interact with AMPKα for proteasomal degradation following sciatic axotomy. Mechanistically, we found that the proteasome and CaMKIIα-dependent proteasomal subunit PSMC5 regulates AMPKα1 protein expression. Finally, conditional deletion of AMPKα1 promoted multiple regenerative signalling pathways and robust axonal growth across the injured spinal cord, suggesting inhibition of AMPK as a novel regenerative target following spinal injury. HIGHLIGHTS Axoplasmic proteomics from sciatic or centrally projecting branches of sciatic DRG identifies unique protein enrichment and signalling pathways, including prior and subsequent to a spinal regeneration-incompetent versus sciatic regeneration-competent axonal injury Combined axoplasmic DRG proteomics and cell body RNAseq analysis suggest AMPK as a central regulator controlling axonal regeneration The 26S proteasome and the 19S regulatory subunit PSMC5 interact with AMPKα following sciatic axotomy. PSMC5 regulates AMPKα1 protein levels AMPKα1 conditional deletion enhances robust axonal growth following SCI
Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Age >69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
2019-06-07

Reduced-intensity conditioning (RIC) allows for the use of allogeneic hematopoietic stem cell transplantation (HSCT) in older patients with acute myelogenous leukemia (AML). We compared outcomes between 713 patients age ≥70 years and 16,161 patients age 50 to 69 years who underwent HSCT between 2004 and 2014. A higher proportion of the older patients were male and had secondary AML, active disease, a peripheral blood stem cell graft, a matched unrelated donor, an RIC regimen, and a lower Karnofsky Performance Status (KPS) score (P< .001). In multivariate analysis, the incidences of acute and chronic graft-versus-host disease and relapse were similar in the 2 age groups. Nonrelapse mortality at 2 years was 34% (95% confidence interval [CI], 31% to 38%) in patients age ≥70 years and 24% (95% CI, 25% to 32%) in those age 50 to 69 years (P< .001). Survival at 2 years in the 2 groups was 38% (95% CI, 34% to 42%) and 50% (95% CI, 49% to 50%), respectively (P< .001). In patients with active disease, the corresponding percentages were 35% (95% CI, 29% to 41%) in those age ≥70 years and 33% (95% CI, 31% to 34%) in those age <70 years (P = .36). In patients age ≥70 years, a KPS score of ≥80% was associated with improved survival (hazard ratio, 1.53; 95% CI, 1.14 to 2.06; P = .003). In summary, patients age ≥70 years had worse outcomes, except for those with active AML.
KCNC1‐related disorders: new de novo variants expand the phenotypic spectrum
2019-06-07

Abstract A recurrent de novo missense variant in KCNC1 , encoding a voltage‐gated potassium channel expressed in inhibitory neurons, causes progressive myoclonus epilepsy and ataxia, and a nonsense variant is associated with intellectual disability. We identified three new de novo missense variants in KCNC1 in five unrelated individuals causing different phenotypes featuring either isolated nonprogressive myoclonus (p.Cys208Tyr), intellectual disability (p.Thr399Met), or epilepsy with myoclonic, absence and generalized tonic‐clonic seizures, ataxia, and developmental delay (p.Ala421Val, three patients). Functional analyses demonstrated no measurable currents for all identified variants and dominant‐negative effects for p.Thr399Met and p.Ala421Val predicting neuronal disinhibition as the underlying disease mechanism.
Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters
2019-06-07

Multicolored gene reporters for light microscopy are indispensable for biomedical research, but equivalent genetic tools for electron microscopy (EM) are still rare despite the increasing importance of nanometer resolution for reverse engineering of molecular machinery and reliable mapping of cellular circuits. We here introduce the fully genetic encapsulin/cargo system of <i>Quasibacillus thermotolerans</i> (Qt), which in combination with the recently characterized encapsulin system from <i>Myxococcus xanthus</i> (Mx) enables multiplexed gene reporter imaging <i>via</i> conventional transmission electron microscopy (TEM) in mammalian cells. Cryo-electron reconstructions revealed that the Qt encapsulin shell self-assembles to nanospheres with <i>T</i> = 4 icosahedral symmetry and a diameter of ∼43 nm harboring two putative pore regions at the 5-fold and 3-fold axes. We also found that upon heterologous expression in mammalian cells, the native cargo is autotargeted to the inner surface of the shell and exhibits ferroxidase activity leading to efficient intraluminal iron biomineralization, which enhances cellular TEM contrast. We furthermore demonstrate that the two differently sized encapsulins of Qt and Mx do not intermix and can be robustly differentiated by conventional TEM <i>via</i> a deep learning classifier to enable automated multiplexed EM gene reporter imaging.
An Fc-Optimized CD133 Antibody for Induction of Natural Killer Cell Reactivity Against Colorectal Cancer
2019-06-07

The introduction of monoclonal antibodies (mAbs) has largely improved treatment options for cancer patients. The ability of antitumor mAbs to elicit antibody-dependent cellular cytotoxicity (ADCC) contributes to a large extent to their therapeutic efficacy. Many efforts accordingly aim to improve this important function by engineering mAbs with Fc parts that display enhanced affinity to the Fc receptor CD16 expressed, e.g., on natural killer (NK) cells. Here we characterized the CD133 mAb 293C3-SDIE that contains an engineered Fc part modified by the amino acid exchanges S239D/I332E—that reportedly increase the affinity to CD16—with regard to its ability to induce NK reactivity against colorectal cancer (CRC). 293C3-SDIE was found to be a stable protein with favorable binding characteristics achieving saturating binding to CRC cells at concentrations of approximately 1 μg/mL. While not directly affecting CRC cell growth and viability, 293C3-SDIE potently induced NK cell activation, degranulation, secretion of Interferon-γ, as well as ADCC resulting in potent lysis of CRC cell lines. Based on the preclinical characterization presented in this study and the available data indicating that CD133 is broadly expressed in CRC and represents a negative prognostic marker, we conclude that 293C3-SDIE constitutes a promising therapeutic agent for the treatment of CRC and thus warrants clinical evaluation.
Health economic evaluation of a web-based intervention for depression: the EVIDENT-trial, a randomized controlled study
2019-06-07

The study indicates the health economic potential of innovative e-mental-health programs. There is evidence to suggest that the use of deprexis over a period of 12 weeks leads to a decrease in outpatient treatment cost, especially in those related to different types of psychotherapeutic treatment.
Association Between Urinary Catecholamine Excretion and Urine Volume
2019-06-07

Abstract Several confounders must be considered in the evaluation of urinary catecholamine excretion. However, literature is contradictory about potential confounders. The aim of the present study was to assess correlations between catecholamine excretion and anthropometric or clinical parameters with special attention to urine volume. A total of 967 24-h urinary catecholamine measurements were performed in 593 patients for diagnostic purposes. The indication for urine examination was suspicion of secondary hypertension, phaeochromocytoma, or paraganglioma. From the patients examined, 57% were females and 43% were males. The patients’ age ranged between 15 and 87 years with a median [Q1; Q3] of 51 [39; 62] years. Seventy-eight percent of the patients suffered from hypertension. Seventy percent of patients took one or more antihypertensive drugs. The most commonly used drugs were ACE inhibitors (43%), while α-blockers (15%) were the least used drugs. Urinary excretion was between 500 and 11 950 ml/24 h with a median of 2200 [1600; 2685] ml/24 h. The median body mass index (BMI) was 26.7 [24.0; 30.4] kg/m2. The excretion of all catecholamines was greater in men than in women (all p&lt;0.0001). Epinephrine (p=0.0026), dopamine (p&lt;0.0001), and metanephrine (p=0.0106) excretion decreased with age. BMI was associated with urinary excretion of dopamine (p&lt;0.0001), norepinephrine (p=0.0026), normetanephrine (p&lt;0.0001), and homovanillylmandelic acid (HVMA; p=0.0251). Urine volume correlated with urinary dopamine (p=0.0127), metanephrine (p&lt;0.0001), normetanephrine (p=0.0070), and HVMA (p&lt;0.0028) excretion. In addition to the established associations between urinary catecholamine excretion and age, gender, and BMI in the present study, urinary catecholamine excretion correlated also with urine volume.
Spatial statistics for gaze patterns in scene viewing
2019-06-07

Scene viewing is used to study attentional selection in complex but still\\ncontrolled environments. One of the main observations on eye movements during\\nscene viewing is the inhomogeneous distribution of fixation locations: While\\nsome parts of an image are fixated by almost all observers and are inspected\\nrepeatedly by the same observer, other image parts remain unfixated by\\nobservers even after long exploration intervals. Here, we apply spatial point\\nprocess methods to investigate the relationship between pairs of fixations.\\nMore precisely, we use the pair correlation function (PCF), a powerful\\nstatistical tool, to evaluate dependencies between fixation locations along\\nindividual scanpaths. We demonstrate that aggregation of fixation locations\\nwithin four degrees is stronger than expected from chance. Furthermore, the PCF\\nreveals stronger aggregation of fixations when the same image is presented a\\nsecond time. We use simulations of a dynamical model to show that a narrower\\nspatial attentional span may explain differences in pair correlations between\\nthe first and the second inspection of the same image.\\n
Annealing Behavior with Thickness Hindered Nucleation in Small-Molecule Organic Semiconductor Thin Films
2019-06-07

We introduce a comprehensive overview of spontaneous and thermal induced structure changes in thin films of the high performance small-molecular organic semiconductor 5,11-bis(triethyl silylethynyl) anthradithiophene (TES-ADT). Most importantly, we find that nucleation of the TES-ADT high temperature β phase can be induced only for films thicker than a critical thickness, while it is hindered for thinner films. The described limited crystal phase nucleation, the circumstances of which are unique in the realm of small-molecule organic semiconductors, is explained in terms of a two step nucleation mechanism while taking into account the anisotropic surface energy of crystal grains. Furthermore, we identify changes in the optical absorption spectra observed during aging of as deposited films with a spontaneous transformation from the amorphous phase to the α2 phase via the α1 phase of TES-ADT. The transformation takes place on the time scale of several days. Finally, we determine temperature dependence of lattice parameters of the α1 and α2 phases and the lattice parameters of the β phase. Thermal expansion of the α1 phase is found to be much lower than that of the α2 phase.
Spatial statistics for gaze patterns in scene viewing: Effects of repeated viewing
2019-06-07

Scene viewing is used to study attentional selection in complex but still controlled environments. One of the main observations on eye movements during scene viewing is the inhomogeneous distribution of fixation locations: While some parts of an image are fixated by almost all observers and are inspected repeatedly by the same observer, other image parts remain unfixated by observers even after long exploration intervals. Here, we apply spatial point process methods to investigate the relationship between pairs of fixations. More precisely, we use the pair correlation function (PCF), a powerful statistical tool, to evaluate dependencies between fixation locations along individual scanpaths. We demonstrate that aggregation of fixation locations within four degrees is stronger than expected from chance. Furthermore, the PCF reveals stronger aggregation of fixations when the same image is presented a second time. We use simulations of a dynamical model to show that a narrower spatial attentional span may explain differences in pair correlations between the first and the second inspection of the same image.
Structural banking reforms and their implications for banks’ corporate governance
2019-06-07

Purpose The purpose of this paper is to examine from a comparative perspective, the impact of structural banking reforms on the legal frameworks for the corporate governance of credit institutions. Design/methodology/approach This facilitates a functional analysis of the resulting corporate governance structures, which in turn provides the basis for an analysis of conceptual concerns with regard to the independence of the separate entity. Findings The paper points out that structural banking reforms come with significant implications for existing corporate governance structures of credit institutions. The resulting corporate governance structures rise conceptual concerns with regard to both the effectiveness of the independence of the separate entity and the objectives of structural banking reforms generally. Practical implications The paper shows that the implementation of structural banking reforms is a complex operational issue and process for the banking groups and the regulators. The challenge will be to establish and upheld the ring fence in a way to lower the risk of intra-group contagion. There is a great need for regulatory and supervisory policies that reinforce the settled ring fence obligations. Originality/value This paper’s value lies in providing analysis of the implications of structural banking reforms for the corporate governance of credit institutions. The relevant statutory frameworks as such set only the core components of the new structure. Defining and implementing the design is left to the discretion of the regulators.
The burden of incontinence in a real-world data environment – insights from a digital patient companion (Preprint)
2019-06-07

<sec> <title>BACKGROUND</title> Urinary Incontinence (UI) can have a potentially devastating effect on women’s quality of life (QoL) in the physical, social, sexual, and psychological spheres. During pregnancy and after delivery, the strength of the pelvic floor muscle may decrease, resulting in a high rate of UI. Conservative treatment by means of pelvic floor muscle training is the first-choice treatment modality. Nowadays, this can be supported by digital apps. Those apps have the advantage of giving insights into real-world data on UI. </sec> <sec> <title>OBJECTIVE</title> The aim of the present study was to analyze the impact of UI on QoL using the app pelvina. </sec> <sec> <title>METHODS</title> We analyzed data from pelvina - a digital health companion pelvic floor course. This course regularly examines incontinence symptoms through “The Questionnaire for Urinary Incontinence Diagnosis” (QUID) and QoL through SF-6D. Subsequently, we analyzed the incidence and degree of incontinence in a real-world environment and determined the influence of different demographic factors. In addition, the impact of UI on the QoL was evaluated in more detail. </sec> <sec> <title>RESULTS</title> In all, 293 patients with a median age of 36 years and a median of 2 deliveries could be included in this study. Patients were slightly to moderately affected by UI with a QUID of 6 (2 - 11, max: 24). Age and parity were independently associated with the incidence of UI with an adjusted odds ratio (aOR) of 1.06 (95% CI 1.01 – 1.12) and aOR of 1.86 (95% CI 1.12 – 3.08), respectively. The severity of incontinence symptoms strongly correlated with impairment in QoL ( = 0.489, P &lt; 0.001). </sec> <sec> <title>CONCLUSIONS</title> The use of real-world data, as generated by digital health solutions such as pelvina, gives us, for the first time, the opportunity to gain insight into the reality of patients' lives outside of classical clinical studies. In this paper we can corroborate the known associations between parity and UI known from the literature and the great influence UI has on QoL on a daily basis. This study shows that, in the future, the use of digital apps can make an important contribution to scientific data acquisition and, for example, therapy monitoring. </sec>