julilili42/papers huggingface dataset:
General-relativistic treatment of tidal g-mode resonances in coalescing binaries of neutron stars – II. As triggers for precursor flares of short gamma-ray bursts
2021-09-14

ABSTRACT In some short gamma-ray bursts, precursor flares occurring ∼ seconds prior to the main episode have been observed. These flares may then be associated with the last few cycles of the inspiral when the orbital frequency is a few hundred Hz. During these final cycles, tidal forces can resonantly excite quasi-normal modes in the inspiralling stars, leading to a rapid increase in their amplitude. It has been shown that these modes can exert sufficiently strong strains on to the neutron star crust to instigate yieldings. Due to the typical frequencies of g- modes being ∼100 Hz, their resonances with the orbital frequency match the precursor timings and warrant further investigation. Adopting realistic equations of state and solving the general-relativistic pulsation equations, we study g-mode resonances in coalescing quasi-circular binaries, where we consider various stellar rotation rates, degrees of stratification, and magnetic field structures. We show that for some combination of stellar parameters, the resonantly excited g1 and g2 modes may lead to crustal failure and trigger precursor flares.
Presentation and discussion of the high-resolution atmosphere–land-surface–subsurface simulation dataset of the simulated Neckar catchment for the period 2007–2015
2021-09-14

Abstract. Coupled numerical models, which simulate water and energy fluxes in the subsurface–land-surface–atmosphere system in a physically consistent way, are a prerequisite for the analysis and a better understanding of heat and matter exchange fluxes at compartmental boundaries and interdependencies of states across these boundaries. Complete state evolutions generated by such models may be regarded as a proxy of the real world, provided they are run at sufficiently high resolution and incorporate the most important processes. Such a simulated reality can be used to test hypotheses on the functioning of the coupled terrestrial system. Coupled simulation systems, however, face severe problems caused by the vastly different scales of the processes acting in and between the compartments of the terrestrial system, which also hinders comprehensive tests of their realism. We used the Terrestrial Systems Modeling Platform (TerrSysMP), which couples the meteorological Consortium for Small-scale Modeling (COSMO) model, the land-surface Community Land Model (CLM), and the subsurface ParFlow model, to generate a simulated catchment for a regional terrestrial system mimicking the Neckar catchment in southwest Germany, the virtual Neckar catchment. Simulations for this catchment are made for the period 2007–2015 and at a spatial resolution of 400 m for the land surface and subsurface and 1.1 km for the atmosphere. Among a discussion of modeling challenges, the model performance is evaluated based on observations covering several variables of the water cycle. We find that the simulated catchment behaves in many aspects quite close to observations of the real Neckar catchment, e.g., concerning atmospheric boundary-layer height, precipitation, and runoff. But also discrepancies become apparent, both in the ability of the model to correctly simulate some processes which still need improvement, such as overland flow, and in the realism of some observation operators like the satellite-based soil moisture sensors. The whole raw dataset is available for interested users. The dataset described here is available via the CERA database (Schalge et al., 2020): https://doi.org/10.26050/WDCC/Neckar_VCS_v1.
Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4)
2021-09-14

The cysteine-rich LIM-only protein 4 (CRP4), a LIM-domain and zinc finger containing adapter protein, has been implicated as a downstream effector of the second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) pathway in multiple cell types, including vascular smooth muscle cells (VSMCs). VSMCs and nitric oxide (NO)-induced cGMP signaling through cGMP-dependent protein kinase type I (cGKI) play fundamental roles in the physiological regulation of vascular tone and arterial blood pressure (BP). However, it remains unclear whether the vasorelaxant actions attributed to the NO/cGMP axis require CRP4. This study uses mice with a targeted deletion of the CRP4 gene (CRP4 KO) to elucidate whether cGMP-elevating agents, which are well known for their vasorelaxant properties, affect vessel tone, and thus, BP through CRP4. Cinaciguat, a NO- and heme-independent activator of the NO-sensitive (soluble) guanylyl cyclase (NO-GC) and NO-releasing agents, relaxed both CRP4-proficient and -deficient aortic ring segments pre-contracted with prostaglandin F2α. However, the magnitude of relaxation was slightly, but significantly, increased in vessels lacking CRP4. Accordingly, CRP4 KO mice presented with hypotonia at baseline, as well as a greater drop in systolic BP in response to the acute administration of cinaciguat, sodium nitroprusside, and carbachol. Mechanistically, loss of CRP4 in VSMCs reduced the Ca2+-sensitivity of the contractile apparatus, possibly involving regulatory proteins, such as myosin phosphatase targeting subunit 1 (MYPT1) and the regulatory light chain of myosin (RLC). In conclusion, the present findings confirm that the adapter protein CRP4 interacts with the NO-GC/cGMP/cGKI pathway in the vasculature. CRP4 seems to be part of a negative feedback loop that eventually fine-tunes the NO-GC/cGMP axis in VSMCs to increase myofilament Ca2+ desensitization and thereby the maximal vasorelaxant effects attained by (selected) cGMP-elevating agents.
The Multitasking Surface Protein of Staphylococcus epidermidis: Accumulation-Associated Protein (Aap)
2021-09-14

The stratum corneum is the outermost layer of the epidermis and is thus directly exposed to the environment. It consists mainly of corneocytes, which are keratinocytes in the last stage of differentiation, having neither nuclei nor organelles.
The Nomological Net of Knowledge, Self-Reported Knowledge, and Overclaiming in Children
2021-09-14

Research on self-reported knowledge and overclaiming in children is sparse. With the current study, we aim to close this gap by developing an overclaiming questionnaire measuring self-reported knowledge and overclaiming that is tailored to children. Moreover, we examine the nomological net of self-reported knowledge and overclaiming in childhood discussing three perspectives: Overclaiming as a) a result of deliberate self-enhancement tendencies, b) a proxy for declarative knowledge, and c) an indicator of creative engagement. We juxtaposed overclaiming, as indicated by claiming familiarity with non-existent terms, and self-reported knowledge with fluid and crystallized intelligence, creativity, and personality traits in a sample of 897 children attending third grade. The results of several latent variable analyses were similar to findings known from adult samples: We found no strong evidence for any of the competing perspectives on overclaiming. Just like in adults, individual differences in self-reported knowledge were strongly inflated by overclaiming, and only weakly related to declarative knowledge.
The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis
2021-09-15

Abstract The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts participate in the bone remodelling process under the regulation of various factors inside and outside. Excessive activation of osteoclasts or lack of function of osteoblasts will cause occurrence and development of multiple bone‐related diseases. Ca 2+ /Calcineurin/NFAT signalling pathway regulates the growth and development of many types of cells, such as cardiomyocyte differentiation, angiogenesis, chondrogenesis, myogenesis, bone development and regeneration, etc. Some evidences indicate that this signalling pathway plays an extremely important role in bone formation and bone pathophysiologic changes. This review discusses the role of Ca 2+ /Calcineurin/NFAT signalling pathway in the process of osteogenic differentiation, as well as the influence of regulating each component in this signalling pathway on the differentiation and function of osteoblasts, whereby the relationship between Ca 2+ /Calcineurin/NFAT signalling pathway and osteoblastogenesis could be deeper understood.
Functional Changes of T-Cell Subsets with Age and CMV Infection
2021-09-15

Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is associated with the expansion of polyfunctional CD57+ T-cells in young and middle-aged individuals in response to different stimuli. Here, we expand our results on the effects of age and CMV infection on T-cell functionality in a cohort of healthy middle-aged and older individuals stratified by CMV serostatus. Specifically, we studied the polyfunctional responses (degranulation, IFN-γ and TNF-α production) of CD4+, CD8+, CD8+CD56+ (NKT-like), and CD4-CD8- (DN) T-cells according to CD57 expression in response to Staphylococcal Enterotoxin B (SEB). Our results show that CD57 expression by T-cells is not only a hallmark of CMV infection in young individuals but also at older ages. CD57+ T-cells are more polyfunctional than CD57− T-cells regardless of age. CMV-seronegative individuals have no or a very low percentages of cytotoxic CD4+ T-cells (CD1017a+) and CD4+CD57+ T-cells, supporting the notion that the expansion of these T-cells only occurs in the context of CMV infection. There was a functional shift in T-cells associated with CMV seropositivity, except in the NKT-like subset. Here, we show that the effect of CMV infection and age differ among T-cell subsets and that CMV is the major driving force for the expansion of highly polyfunctional CD57+ T-cells, emphasizing the necessity of considering CMV serology in any study of immunosenescence.
Unfolding Trade Effect in Two Margins of Informality. The Peruvian Case
2021-09-15

Abstract This paper studies the effect of an increase in import competition on informality along two margins. It considers the extensive margin, where workers are hired by unregistered employers, and the intensive margin, where even though jobs are carried out by registered firms, employees are off the books. Peru’s relentless informal employment and its unprecedented trade-driven growth provides an ideal case study. Using a rich household survey, this study finds that exposure to trade impacts on informality through two competing and contrasting mechanisms. On the one hand, extensive-informal employment declines as unregistered employers shrink or exit due to their low productivity. On the other hand, intensive-informal employment rises as registered employers reduce costs by hiring informal workers. Furthermore, results suggest that the intensive margin drives the overall effect. Hence, trade liberalization increases informality.
Breast cancer risks associated with missense variants in breast cancer susceptibility genes
2021-09-15

Abstract BACKGROUND Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2 and PALB2 are associated with increased breast cancer risk, but risks associated with missense variants in these genes are uncertain. METHODS Combining 59,639 breast cancer cases and 53,165 controls, we sampled training (80%) and validation (20%) sets to analyze rare missense variants in ATM (1,146 training variants), BRCA1 (644), BRCA2 (1,425), CHEK2 (325) and PALB2 (472). We evaluated breast cancer risks according to five in-silico prediction-of-deleteriousness algorithms, functional protein domain, and frequency, using logistic regression models and also mixture models in which a subset of variants was assumed to be risk-associated. RESULTS The most predictive in-silico algorithms were Helix ( BRCA1, BRCA2 and CHEK2) and CADD ( ATM ). Increased risks appeared restricted to functional protein domains for ATM (FAT and PIK domains) and BRCA1 (RING and BRCT domains). For ATM, BRCA1 and BRCA2 , data were compatible with small subsets (approximately 7%, 2% and 0.6%, respectively) of rare missense variants giving similar risk to those of protein truncating variants in the same gene. For CHEK2 , data were more consistent with a large fraction (approximately 60%) of rare missense variants giving a lower risk (OR 1.75, 95% CI (1.47-2.08)) than CHEK2 protein truncating variants. There was little evidence for an association with risk for missense variants in PALB2 . The best fitting models were well calibrated in the validation set. CONCLUSIONS These results will inform risk prediction models and the selection of candidate variants for functional assays, and could contribute to the clinical reporting of gene panel testing for breast cancer susceptibility.
What causes differences in fracture rates of silcrete during heat treatment? A near-infrared study of water-related transformations in South African silcretes
2021-09-15

Discussions of heat treatment in the southern African Middle Stone Age often focus on the importance of this innovation to the development of complex technologies and the evolution of modern human cognition. Debates regarding the context of silcrete heat treatment typically include the amount of time and resource investment needed, and when the earliest occurrences of heat treatment appear in the archaeological record. However, silcrete is a heterogeneous material and the potential effects of this heterogeneity on the thermal transformations that occur during heat treatment are not well established. We undertook a series of controlled experiments using direct transmission near-infrared spectroscopy on South African silcretes from multiple sources heated to a range of maximum temperatures to examine the degree of heterogeneity in starting structural content and the evolution of thermal transformations. We found that material source is an important determinant of starting concentrations of H2O, SiOH, and pore space in silcrete, as well as the thermal evolution of these variables. These results shed light on the degree and sources of variation in the structural content and thermal behavior of silcrete during heat treatment and allow for a better understanding of the heterogeneity of silcrete as a raw material and the implications of this for African Middle Stone Age pyrotechnology.
Targeted pharmacological therapy restores β-cell function for diabetes remission
2021-09-15

This experimental mouse study examined whether or not dedifferentiated β cells could be reversed or targeted by pharmacological intervention for diabetes remission. They identified evidence for β-cell dedifferentiation and dysfunction which could be reversed by single and combined pharmacological approaches.
Heterodimers of functionally divergent ARF-GEF paralogues prevented by self-interacting dimerisation domain
2021-09-15

Abstract Functionally divergent paralogs of homomeric proteins do not form potentially deleterious heteromers, which requires distinction between self and non-self (Hochberg et al., 2018; Marchant et al, 2019; Marsh and Teichmann, 2015). In Arabidopsis, two ARF guanine-nucleotide exchange factors (ARF-GEFs) related to mammalian GBF1, named GNOM and GNL1, can mediate coatomer complex (COPI)-coated vesicle formation in retrograde Golgi-endoplasmic reticulum (ER) traffic (Geldner et al., 2003; Richter et al., 2007; Teh and Moore, 2007). Unlike GNL1, however, GNOM is also required for polar recycling of endocytosed auxin efflux regulator PIN1 from endosomes to the plasma membrane. Here we show that these paralogues form homodimers constitutively but no heterodimers. We also address why and how GNOM and GNL1 might be kept separate. These paralogues share a common domain organisation and each N-terminal dimerisation (DCB) domain can interact with the complementary fragment (ΔDCB) of its own and the other protein. However, unlike self-interacting DCB GNOM (Grebe et al., 2000; Anders et al., 2008), DCB GNL1 did not interact with itself nor DCB GNOM . DCB GNOM removal or replacement with DCB GNL1 , but not disruption of cysteine bridges that stabilise DCB-DCB interaction, resulted in GNOM-GNL1 heterodimers which impaired developmental processes such as lateral root formation. We propose precocious self-interaction of the DCB GNOM domain as a mechanism to preclude formation of fitness-reducing GNOM-GNL1 heterodimers.
Evolutionary Reinforcement Learning Dynamics with Irreducible Environmental Uncertainty.
2021-09-15

In this work we derive and present evolutionary reinforcement learning dynamics in which the agents are irreducibly uncertain about the current state of the environment. We evaluate the dynamics across different classes of partially observable agent-environment systems and find that irreducible environmental uncertainty can lead to better learning outcomes faster, stabilize the learning process and overcome social dilemmas. However, as expected, we do also find that partial observability may cause worse learning outcomes, for example, in the form of a catastrophic limit cycle. Compared to fully observant agents, learning with irreducible environmental uncertainty often requires more exploration and less weight on future rewards to obtain the best learning outcomes. Furthermore, we find a range of dynamical effects induced by partial observability, e.g., a critical slowing down of the learning processes between reward regimes and the separation of the learning dynamics into fast and slow directions. The presented dynamics are a practical tool for researchers in biology, social science and machine learning to systematically investigate the evolutionary effects of environmental uncertainty.
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes: Results of the Randomized Controlled Prediabetes Lifestyle Intervention Study (PLIS)
2021-09-16

Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes with low risk (LR) benefit from conventional LI and individuals with high risk (HR) benefit from an intensification of LI in a multicenter randomized controlled intervention over 12 months with 2 years’ follow-up. A total of 1,105 individuals with prediabetes based on American Diabetes Association glucose criteria were stratified into an HR or LR phenotype based on previously described thresholds of insulin secretion, insulin sensitivity, and liver fat content. LR individuals were randomly assigned to conventional LI according to the Diabetes Prevention Program (DPP) protocol or control (1:1) and HR individuals to conventional or intensified LI with doubling of required exercise (1:1). A total of 908 (82%) participants completed the study. In HR individuals, the difference between conventional and intensified LI in postchallenge glucose change was −0.29 mmol/L [95% CI −0.54; −0.04], P = 0.025. Liver fat (−1.34 percentage points [95% CI −2.17; −0.50], P = 0.002) and cardiovascular risk (−1.82 percentage points [95% CI −3.13; −0.50], P = 0.007) underwent larger reductions with intensified than with conventional LI. During a follow-up of 3 years, intensified compared with conventional LI had a higher probability of normalizing glucose tolerance (P = 0.008). In conclusion, it is possible in HR individuals with prediabetes to improve glycemic and cardiometabolic outcomes by intensification of LI. Individualized, risk phenotype–based LI may be beneficial for the prevention of diabetes.
Update on Novel Non-Operative Treatment for Osteoarthritis: Current Status and Future Trends
2021-09-16

Osteoarthritis (OA) is a leading cause of pain and disability which results in a reduced quality of life. Due to the avascular nature of cartilage, damaged cartilage has a finite capacity for healing or regeneration. To date, conservative management, including physical measures and pharmacological therapy are still the principal choices offered for OA patients. Joint arthroplasties or total replacement surgeries are served as the ultimate therapeutic option to rehabilitate the joint function of patients who withstand severe OA. However, these approaches are mainly to relieve the symptoms of OA, instead of decelerating or reversing the progress of cartilage damage. Disease-modifying osteoarthritis drugs (DMOADs) aiming to modify key structures within the OA joints are in development. Tissue engineering is a promising strategy for repairing cartilage, in which cells, genes, and biomaterials are encompassed. Here, we review the current status of preclinical investigations and clinical translations of tissue engineering in the non-operative treatment of OA. Furthermore, this review provides our perspective on the challenges and future directions of tissue engineering in cartilage regeneration.
Unequal Inclusion: The Production of Social Differences in Education Systems
2021-09-16

The article raises the question of whether and how education systems produce social differences internally rather than reproducing pre‐existing “external” inequalities. Linking Niklas Luhmann’s theory of inclusion/exclusion with Charles Tilly’s theory of categorical inequalities, and based on empirical data from various qualitative studies, the article identifies an “observation regime” epistemically constituting the social classification of students and legitimising organisational closure mechanisms in the school system. As an alternative to the “reproduction paradigm,” a research approach guided by differentiation theory is proposed that takes into account that educational inequality operationally arises on the “inside” of the educational system and is caused by unequal inclusion processes.
Climate change and the different roles of physicians: a critical response to "A Planetary Health Pledge for Health Professionals in the Anthropocene"
2021-09-16

Abstract The article critically responds to "A Planetary Health Pledge for Health Professionals in the Anthropocene" which was published by Wabnitz et al. in The Lancet in November 2020. It focuses on the different roles and responsibilities of a physician. The pledge is criticised because it neglects the different roles, gives no answers in case of conflicting goals, and contains numerous inconsistencies. The relationship between the Planetary Health Pledge and the Declaration of Geneva is examined. It is argued that the Planetary Health Pledge should have supplemented the Declaration of Geneva instead of changing it.
Quantitative Susceptibility Mapping of the Basal Ganglia and Thalamus at 9.4 Tesla
2021-09-16

The thalamus (Th) and basal ganglia (BG) are central subcortical connectivity hubs of the human brain, whose functional anatomy is still under intense investigation. Nevertheless, both substructures contain a robust and reproducible functional anatomy. The quantitative susceptibility mapping (QSM) at ultra-high field may facilitate an improved characterization of the underlying functional anatomy in vivo . We acquired high-resolution QSM data at 9.4 Tesla in 21 subjects, and analyzed the thalamic and BG by using a prior defined functional parcellation. We found a more substantial contribution of paramagnetic susceptibility sources such as iron in the pallidum in contrast to the caudate, putamen, and Th in descending order. The diamagnetic susceptibility sources such as myelin and calcium revealed significant contributions in the Th parcels compared with the BG. This study presents a detailed nuclei-specific delineation of QSM-provided diamagnetic and paramagnetic susceptibility sources pronounced in the BG and the Th. We also found a reasonable interindividual variability as well as slight hemispheric differences. The results presented here contribute to the microstructural knowledge of the Th and the BG. In specific, the study illustrates QSM values (myelin, calcium, and iron) in functionally similar subregions of the Th and the BG.