PD21-01 MULTI-NATIONAL, PROSPECTIVE, RANDOMIZED STUDY OF THE PROSTATIC URETHRAL LIFT (PUL) VS. TRANSURETHRAL RESECTION OF THE PROSTATE (TURP): TWO YEAR RESULTS
2016-03-28

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy & New Technology I1 Apr 2016PD21-01 MULTI-NATIONAL, PROSPECTIVE, RANDOMIZED STUDY OF THE PROSTATIC URETHRAL LIFT (PUL) VS. TRANSURETHRAL RESECTION OF THE PROSTATE (TURP): TWO YEAR RESULTS Jens Sonsken, Neil Barber, Mark Speakman, Richard Berges, Ulrich Wetterauer, Damian Greene, Karl-Dietrich Sievert, Christopher Chapple, Francesco Montorsi, Lasse Fahrenkrug, and Christian Gratzke Jens SonskenJens Sonsken More articles by this author , Neil BarberNeil Barber More articles by this author , Mark SpeakmanMark Speakman More articles by this author , Richard BergesRichard Berges More articles by this author , Ulrich WetterauerUlrich Wetterauer More articles by this author , Damian GreeneDamian Greene More articles by this author , Karl-Dietrich SievertKarl-Dietrich Sievert More articles by this author , Christopher ChappleChristopher Chapple More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Lasse FahrenkrugLasse Fahrenkrug More articles by this author , and Christian GratzkeChristian Gratzke More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1468AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES TURP is the gold standard therapy for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and offers significant symptom relief and flow rate improvement. TURP can be associated with complications such as incontinence, sexual dysfunction and a lengthy recovery period. The Prostatic Urethral Lift (PUL) is a less invasive alternative that may overcome these limitations. We present the 2 year results of a randomized, controlled trial comparing PUL to TURP. METHODS At 10 European centers, 80 men with BPH LUTS were randomized to either PUL (N=45) or standard TURP (N=35). PUL procedure entails transurethrally placing small permanent UroLift® implants into the lateral lobes of the prostate to reduce obstruction. The BPH6 endpoint, which measures symptom relief, quality of recovery, erectile function, ejaculatory function, continence preservation, and safety was assessed at 2 years. Secondary evaluations considered International Prostate Symptom Score (IPSS), quality of life, BPH Impact Index, peak flow rate, Sexual Health Inventory for Men (SHIM), and Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD). RESULTS IPSS improvement was significant in both PUL (-9.2±9.2) and TURP (-15.3±7.5) arms through 2 years. Quality of life and BPH Impact Index were also significantly improved in both arms (Table 1). TURP IPSS and peak flow rate improvement was significantly better than PUL. Erectile function was preserved in both arms, while ejaculatory function was significantly compromised in the TURP arm. At 2 years, a significantly greater number of PUL subjects than TURP subjects responded on the BPH6 primary endpoint (46% PUL vs 22% TURP, p=0.05). CONCLUSIONS Consistent with the previously published 1 year results, the PUL procedure demonstrated superiority to TURP at 2 years on the BPH6 endpoint. TURP was superior to PUL in reducing IPSS and improving peak flow rate. PUL resulted in superior quality of recovery and ejaculatory function. The BPH6 study is the first prospective, randomized trial comparing PUL with TURP and offers a unique opportunity to directly compare these therapies on patient-driven outcomes such as sexual function preservation and recovery experience. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e456 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Jens Sonsken More articles by this author Neil Barber More articles by this author Mark Speakman More articles by this author Richard Berges More articles by this author Ulrich Wetterauer More articles by this author Damian Greene More articles by this author Karl-Dietrich Sievert More articles by this author Christopher Chapple More articles by this author Francesco Montorsi More articles by this author Lasse Fahrenkrug More articles by this author Christian Gratzke More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...