julilili42/papers huggingface dataset:
Molecular Network Guided Cataloging of the Secondary Metabolome of Selected Egyptian Red Sea Soft Corals
2022-10-01

Soft corals are recognized as an abundant source of diverse secondary metabolites with unique chemical features and physiologic capabilities. However, the discovery of these metabolites is usually hindered by the traditional protocol which requires a large quantity of living tissue for isolation and spectroscopic investigations. In order to overcome this problem, untargeted metabolomics protocols have been developed. The latter have been applied here to study the chemodiversity of common Egyptian soft coral species, using only minute amounts of coral biomass. Spectral similarity networks, based on high-resolution tandem mass spectrometry data, were employed to explore and highlight the metabolic biodiversity of nine Egyptian soft coral species. Species-specific metabolites were highlighted for future prioritization of soft coral species for MS-guided chemical investigation. Overall, 79 metabolites were tentatively assigned, encompassing diterpenes, sesquiterpenes, and sterols. Simultaneously, the methodology assisted in shedding light on newly-overlooked chemical diversity with potential undescribed scaffolds. For instance, glycosylated fatty acids, nitrogenated aromatic compounds, and polyketides were proposed in Sinularia leptoclados, while alkaloidal terpenes and N-acyl amino acids were proposed in both Sarcophyton roseum and Sarcophyton acutum.
Platelets and Sera from Donors of Convalescent Plasma after Mild COVID-19 Show No Procoagulant Phenotype
2022-10-01

Abstract Coronavirus disease-2019 (COVID-19) is associated with increased thromboembolic complications. Long-term alteration in the coagulation system after acute COVID-19 infection is still a subject of research. Furthermore, the effect of sera from convalescent subjects on platelets is not known. In this study, we investigated platelet phenotype, coagulation, and fibrinolysis in COVID-19 convalescent plasma (CCP) donors and analyzed convalescent sera-induced effects on platelets. We investigated CCP donors who had a history of mild COVID-19 infection and donors who did not have COVID-19 were used as controls. We analyzed phosphatidylserine (PS) externalization, CD62p expression, and glycoprotein VI (GPVI) shedding both in platelet-rich plasma (PRP) and after incubation of washed healthy platelets with donors' sera using flow cytometry. Coagulation and fibrinolysis systems were assessed with thromboelastometry. Forty-seven CCP donors (22 males, 25 females; mean age (±SD): 41.4 ± 13.7 years) with a history of mild COVID-19 infection were included. Median duration after acute COVID-19 infection was 97 days (range, 34–401). We did not find an increased PS externalization, CD62p expression, or GPVI shedding in platelets from CCP donors. Sera from CCP donors did not induce PS externalization or GPVI shedding in healthy platelets. Sera-induced CD62p expression was slightly, albeit statistically significantly, lower in CCP donors than in plasma donors without a history of COVID-19. One patient showed increased maximum clot firmness and prolonged lysis time in thromboelastometry. Our findings suggest that procoagulant platelet phenotype is not present after mild COVID-19. Furthermore, CCP sera do not affect the activation status of platelets.
Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms
2022-10-01

Abstract Background Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. Aims To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies. Methods Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940), the Whitehall II study, UK (n = 4469) and the Canadian Longitudinal Study on Aging, Canada (n = 13,720). Results Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively). Conclusions Evidence from three independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline. Key messages • Cardiometabolic dysregulation and depression might increase cognitive decline. • The association between cardiometabolic dysregulation and cognitive decline might be mediated by depression.
The COVID-19 pandemic and its impact on medical teaching in obstetrics and gynecology – A nationwide expert survey among teaching coordinators at German university hospitals
2022-10-01

Purpose The COVID-19 pandemic has imposed severe challenges on medical education at German university hospitals. In this first German nationwide expert survey, we addressed the responsible university teaching coordinators in obstetrics and gynecology departments and investigated their experiences during the pandemic as well as their opinions on future developments, especially with regard to the broader implementation of e-learning in the standard curriculum.
Depression, diabetes and change in cognitive functioning: results from the Canadian Longitudinal study on Aging
2022-10-01

Abstract Background Individuals who ultimately receive a diagnosis of dementia typically have an observable accelerated cognitive decline (ACD) many years prior to diagnosis. Depression in combination with diabetes is an emerging risk factor that is associated with cognitive problems. Using data from the Canadian Longitudinal Study on Aging, the objective of the present study was to investigate the longitudinal association between depression, diabetes, and cognitive decline in an elderly cohort. Methods Baseline and follow-up data from a population-based study in Canada were used. The sample consisted of 18161 adults between 45 and 85 years of age without diabetes. Cognitive functioning was assessed at baseline and after 4 years using six measures: the Rey Auditory Verbal Learning Test (RAVLT), the Mental Alternation Test (MAT), the Animal Fluency Test (AF), the Controlled Oral Word Association Test (COWAT), the Stroop Test, and the Prospective Memory Test. Depression was assessed using the CES-D10. Regression analysis was conducted to evaluate interactions between depression, diabetes and cognitive decline. Results The mean age of participants was 61 years. Participants with a comorbidity of depression and diabetes had an accelerated cognitive decline (g-factor) compared to those with depression without diabetes and those with diabetes without depression (regression coefficients ß=-0.145 (0.036), ß=-0.076 (0.011), and ß=-0.053 (0.021), respectively). Conclusions This study suggests that depression and diabetes might increase the risk of cognitive decline in a synergistic way.
Digital health literacy and health behaviors of eighth and ninth graders from Germany
2022-10-01

Abstract Background Due to the high availability and use of digital media, health-related information is increasingly shifting into the digital space. While there are increasing empirical findings on general health literacy (HL), there is a lack of evidence on digital HL in adolescence and its association with health behavior. Methods A cross-sectional study of 490 secondary school students (grades eight and nine) from the federal state of Hesse was conducted from October 2019 to February 2020. Digital HL was assessed using five subscales of the Digital Health Literacy Instrument (DHLI), while consumption of fruits, vegetables, soft drinks, and weekly physical activity were used as indicators of health behavior. In addition to gender and grade level, subjective social status (SSS) was used as a social characteristic. Univariate, bivariate, and multivariate analyses were performed, with binary-logistic regression adjusted for gender and SSS. Results Across all items, the percentage of adolescents reporting difficulties in acquiring and dealing with digital health information ranges from 15.3 % to 37.5 %. Stratified by social characteristics, gender and socioeconomic differences were found with girls and respondents reporting a lower SSS more often showing a limited digital HL. Adolescents with moderate and low digital HL report higher levels of low physical activity, non-daily fruit and daily soft drink consumption. Depending on the health behavior, different relationship patterns can be observed for the dimensions of digital HL. Conclusions The findings suggest a need for interventions to promote digital HL among adolescents, particularly for those of low SSS. In this context, the differential relationship patterns with health behaviors provide an avenue for the development of specific interventions.
Childhood trauma, depression, and the risk of incident prediabetes in young adults: findings from the Lifelines Cohort Study
2022-10-01

Abstract Background Childhood trauma and depression have been shown to increase the risk of type 2 diabetes. However, many studies have focused on middle-age and older adults, with less known on the role of these variables in early glucose dysregulation. The goal of the study was to examine childhood trauma, depression, and their interactions, as risk factors for the onset of prediabetes in young adults. Methods Data were from the Dutch Lifelines Cohort Study. N = 8,650 adults (61% female) between 18-35 years without prediabetes/diabetes at baseline (2007-2014) were included. Childhood trauma was assessed using the Childhood Trauma Questionnaire. Depression was assessed using the Mini International Neuropsychiatric Interview. Prediabetes at follow-up (2014-2017) was considered by haemoglobin A1c levels between 5.7%-6.4%. Logistic regressions examined associations between depression and childhood trauma with the risk of incident prediabetes. Odds ratios (OR) and 95% confidence intervals (CI) for unadjusted analyses and analyses adjusted for age, sex, education, ethnicity, body mass index, smoking, and alcohol use (reduced adjusted sample size; n = 7,186) are presented. Results 244 participants (2.8%) developed prediabetes. In univariate analyses, childhood trauma (OR = 1.02, CI = 1.01-1.03, p=.006) and depression (OR = 2.08, CI = 1.01-4.29, p=.048) predicted incident prediabetes. When childhood trauma subscales were examined, only sexual abuse significantly predicted incident prediabetes. In adjusted analyses, only childhood trauma, specifically sexual abuse, significantly predicted incident prediabetes (OR = 1.06, CI = 1.01-1.12, p=.021). No multiplicative interaction between depression and childhood trauma was found. Conclusions Young adults who have experienced childhood trauma, particularly sexual abuse, may be at risk of glucose dysregulation in early adulthood. Early targeted preventive care may help attenuate or halt glucose dysregulation and the development of type 2 diabetes.
Digital phenotyping for monitoring and prediction of physical activity level during pregnancy
2022-10-01

Abstract Background Gestational diabetes mellitus (GDM) is one of the most common complications in pregnancy. Physical activity (PA) during pregnancy may reduce the adverse pregnancy outcomes. Digital phenotyping can develop interactive risk profiles to better reflect a person’s daily mobility than traditional retrospective self-assessment questionnaires. Therefore, the aims of the proposed research are to 1) test the acceptability and applicability of the BEIWE app during pregnancy, 2) characterize daily physical mobility during pregnancy, and 3) describe differences in physical mobility in women with and without diabetes. Methods This prospective cohort study will include 20 pregnant women with GDM and 20 without GDM from the Diabetes Center of the Medical Clinic or outpatient clinics of the Tübingen Women’s Clinic, Tuebingen, Germany. The study was approved by the Ethics Committee of the University Hospital Tuebingen (004/2022BO1). At baseline (22 weeks gestation), participants will be instructed to download the app. Passive data (phenotypic information) is collected automatically during the observation period. The follow-up assessment will be conducted three weeks after delivery. The acceptance of the app and comparison of the groups with and without diabetes will be conducted through Statistical analysis. Results Recruitment of participants has started and follow-up assessment is estimated to be finalized in fall 2022. Study design and results will be presented at the conference. Conclusions PA during pregnancy has been associated with minimum risk of a pregnancy, and self-monitoring of PA via an app may play a role in improving pregnancy outcomes. However, the success of Apps depends on their validity and reliability, which lack evidence. Key messages • The result of the study will develop a qualification measure for PA with no intervention. • It also provides information for planning and conducting subsequent intervention studies.
Systemic inflammation and the risk of depression in people with type 2 diabetes
2022-10-01

Abstract Background Depression is a common co-morbidity in diabetes. The mechanisms underlying the association between depression and diabetes are poorly understood. Although risk factors, such as poor lifestyle behaviours, obesity, and stress have been identified, emerging evidence suggests that systemic inflammation may play an important role in the pathogenesis and recurrence of depression in people with diabetes. The aim of the present study was to evaluate if the inflammatory marker C-reactive protein (CRP) is associated with an increased risk of major depression episodes in people with type 2 diabetes. Methods A prospective, community-based study was conducted in Quebec, Canada. Individuals were recruited from the CARTaGENE (CaG) cohort, a population-based survey of Quebec residents aged 40 to 69 years. Our sample included 719 individuals with type 2 diabetes and 1423 individuals without diabetes. Individuals were assessed at baseline and 5 years after baseline. Major depression disorders were assessed using a clinical interview (CIDI). Inflammatory markers were assessed from blood samples. Elevated CRP levels were defined as ≥ 3 mg/L. Results Participants with both diabetes and elevated CRP levels had the highest risk of major depressive episodes (adjusted OR = 1.90, 95% CI 1.45, 2.50), compared to those without diabetes and without elevated CRP levels. The risk of major depressive episodes in individuals with diabetes without elevated CRP episodes was lower (adjusted OR = 1.21, 95% CI 0.85, 1.73) and similar to the risk of those without diabetes and elevated CRP levels (adjusted OR = 1.15, 95% CI 0.94, 1.39). Discussion The study highlights the interaction between diabetes, inflammatory makers, and depression in a community sample. Early identification, monitoring, and management of elevated inflammation levels might be an important depression prevention strategy in people with type 2 diabetes.
Time at home during the COVID-19 pandemic: a prospective examination of psychosocial health in people with and without type 2 diabetes using digital phenotyping
2022-10-01

Abstract Introduction Societal restrictions due to COVID-19 have had a profound effect on our ability to connect with one another and limited our personal mobility. There is evidence that loneliness, social isolation, and psychological distress increased during restrictions for people with diabetes. Fluctuating restrictions provide a unique opportunity to utilise continuous GPS data from personal smartphones (digital phenotypes) to explore the relationship between time-at-home and psychosocial health for people with diabetes. This study aims to (1) describe the digital phenotypes of time-at-home during varying societal COVID-19 restrictions for people with and without type 2 diabetes and (2) to explore associations between these digital phenotypes and loneliness, social support, and other psychosocial factors and compare for people with and without type 2 diabetes. Methods Data come from a longitudinal observational study in the Republic of Ireland that ran between March and August 2021. Participants are seventy-four adults (64.8% female; median age-group = 50-54) with (N = 40) and without (N = 34) diabetes. Continuous GPS data were recorded for 2 months through the Beiwe smartphone application. Loneliness (UCLA-3), social support (MSPSS), diabetes stigma (DSAS-2; diabetes cohort only) as well as other demographic, psychosocial, and lifestyle questionnaires were assessed at baseline, 1 month, and 2 months follow-up. Analysis GPS data are being processed. The GPS-derived features of time-at-home, overall movement, and location variance will be computed. Associations between these digital phenotypes and psychosocial factors will be explored and changes over time examined using multilevel modeling. Conclusions We expect this study to be the first to describe and compare the digital phenotypes of people with and without diabetes during varying societal COVID-19 restrictions, providing new insights into the effects of such policies on the psychosocial health of people with diabetes.
Oncological outcomes of patients with cervical cancer after fertility-sparing treatment – fertiss retrospective multicenter trial
2022-10-01

Objective Fertility-sparing treatment (FST) has become a treatment option in patients with early stage cervical cancer. This study collected multi-institutional real-world data on treatment and oncological outcome.
A noninvasive auditory prosthesis: Evaluation of a safety margin of the transtympanic laser stimulation
2022-10-01

Cochlear implants are widely used for compensating the sensorineural hearing loss. Surgical intervention for implanting electrodes is one of the most significant obstacle for the further widespread of these devices. We proposed a non-invasive auditory prosthesis using infrared laser because the laser can stimulate cochlea nerves from the outer ear. The purpose of this study was to evaluate the safety margin of the transtympanic laser stimulation. Head-fixed classical conditioning was performed on Mongolian gerbils. Subjects were trained using auditory stimulus, a bandpass noise, as a conditioned stimulus for a water reward, and licking behavior was recorded as a conditioned response. After the training, each subject was exposed to continuous pulsed laser irradiation of 1.6, 3.3, 6.6, 26.4, 52.8, or 105.6 W/cm2 for 15 hours. The bandpass noise with various intensities was presented without the reward before and after one-day of the laser exposure. As a result, the licking rate did not change after laser exposure of 6.6 W/cm2 or weaker, but drastically decreased after 26.4 W/cm2or above. The result suggests that the injury threshold in Mongolian gerbils for transtympanic laser stimulation is between 6.6 and 26.4 W/cm2 and the exposure over 6.6 W/cm2 could be out of the safety margin.
“Que ignores mi idioma no me espanto”: el soneto en español en Bian zhengjiao zhenchuan shilu 辯正教真傳實錄 o Apología de la Verdadera Religión (1593) de Fray Juan Cobo 高母羡:“Que ignores mi idioma no me espanto”: The Sonnet in Spanish in Bian zhengjiao zhenchuan shilu 辯正教真傳實錄 or Apología de la Verdadera Religión (1593) by Fray Juan Cobo 高母羡
2022-10-01

Abstract In Shih-Lu, Testimony of the True Religion實錄 Shih-lu (Manila, 1593) by the Dominican Fray Juan Cobo (c. 1546–1592), there is a handwritten sonnet added after the book’s publication, which has not been studied in the context of the Sino-Spanish books published in the Philippines. In the only extant copy, the beginnings and endings of the book are confused; much as in the sonnet the beginnings and endings are an unsolvable oxymoron for the reader who does not have a good Chinese teacher. This copy of the book contains several of these misunderstandings because, for centuries, the owners and users of the book where unable to read it. The autographed and anonymous sonnet accurately reflects this situation.
2022-RA-211-ESGO Expression of the anti-angiogenic VEGF-A splice variant, VEGF-A 165 b, as predictive biomarker for bevacizumab treatment in advanced ovarian cancer patients
2022-10-01

<h3>Introduction/Background</h3> The identification of a robust immunohistochemical marker to predict the response to bevacizumab in ovarian cancer is of high clinical interest. VEGF-A, the molecular target of bevacizumab, is expressed as multiple isoforms with pro- or anti-angiogenic properties, of which VEGF-A<sub>165</sub>b is the most dominant anti-angiogenic isoform. The balance of VEGF-A isoforms is closely related to the angiogenic capacity of a tumor and may define its vulnerability to anti-angiogenic therapy. We investigated, whether expression of VEGF-A<sub>165</sub>b is a predictive biomarker for bevacizumab treatment in advanced ovarian cancer. <h3>Methodology</h3> Formalin-fixed paraffin-embedded (FFPE) tissues from 413 patients of the ICON7 multicenter phase III trial, treated with standard platinum-based chemotherapy with or without bevacizumab, were probed for VEGF-A<sub>165</sub>b expression by immunohistochemistry. <h3>Results</h3> In patients with low VEGF-A<sub>165</sub>b expression, the addition of bevacizumab to standard platinum-based chemotherapy significantly improved progression-free (HR: 0.727, 95%CI=0.538 – 0.984; p=0.039) and overall survival (HR: 0.662, 95%CI=0.458 – 0.958; p=0.029). Multivariate analysis showed that the addition of bevacizumab in low VEGF-A<sub>165</sub>b expressing patients conferred significant improvements in progression-free survival (HR: 0.610, 95%CI=0.446 – 0.834; p=0.002) and overall survival (HR: 0.527, 95%CI=0.359 – 0.775; p=0.001), independently from established risk factors. <h3>Conclusion</h3> We demonstrate for the first time that immunohistochemical expression of the anti-angiogenic VEGF-A isoform, VEGF-A<sub>165</sub>b, is an independent predictor for bevacizumab treatment in ovarian cancer patients. We envision that this marker could be implemented into routine diagnostics in ovarian cancer and may guide clinical decisions related to bevacizumab treatment.