2309 IMPACT OF CLINICAL PARAMETERS ON THE DIAGNOSTIC ACCURACY OF ENDORECTAL COIL MAGNETIC RESONANCE IMAGING FOR THE DETECTION OF PROSTATE CANCER
2011-04-01

You have accessJournal of UrologyImaging/Radiology: Uroradiology1 Apr 20112309 IMPACT OF CLINICAL PARAMETERS ON THE DIAGNOSTIC ACCURACY OF ENDORECTAL COIL MAGNETIC RESONANCE IMAGING FOR THE DETECTION OF PROSTATE CANCER Daniela Colleselli, Joerg Hennenlotter, Stefan Krueger, David Schilling, Georgios Gakis, Mathias Lichy, Ulrich Vogel, Ursula Kuehs, Heinz-Peter Schlemmer, Arnulf Stenzl, and Christian Schwentner Daniela ColleselliDaniela Colleselli Tuebingen, Germany More articles by this author , Joerg HennenlotterJoerg Hennenlotter Tuebingen, Germany More articles by this author , Stefan KruegerStefan Krueger Tuebingen, Germany More articles by this author , David SchillingDavid Schilling Tuebingen, Germany More articles by this author , Georgios GakisGeorgios Gakis Tuebingen, Germany More articles by this author , Mathias LichyMathias Lichy Heidelberg, Germany More articles by this author , Ulrich VogelUlrich Vogel Tuebingen, Germany More articles by this author , Ursula KuehsUrsula Kuehs Tuebingen, Germany More articles by this author , Heinz-Peter SchlemmerHeinz-Peter Schlemmer Heidelberg, Germany More articles by this author , Arnulf StenzlArnulf Stenzl Tuebingen, Germany More articles by this author , and Christian SchwentnerChristian Schwentner Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2555AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES For preoperative assessment, endorectal coil magnetic resonance imaging (endoMRI) of the prostate is a useful tool to evaluate tumor localization, size and topographic relation to the neurovascular bundles. However, there is little evidence of patient characteristics affecting its diagnostic performance. The aim of this study was to evaluate the influence of clinical and histological parameters on the accuracy of endoMRI in prostate cancer patients. METHODS 69 consecutive patients with histologically proven prostate cancer were included into the study. After virtually dividing the prostate into pixels of one cm2 results of endoMRI were compared to the corresponding results from prostatectomy specimens' whole mount sections by pixel. Univariate and multivariate analyses were performed to calculate the impact of clinical and histological parameters on the number of appropriately described pixels. RESULTS In 9 patients no tumor could be demonstrated by endoMRI. 48.3% of the remaining patients were staged correctly, 23.3% were over- and 28.3% under staged. Overall, mean rate of correctly labelled pixels were 0.44 (±SEM 0.04) for tumor and 0.90 (±0.01) for benign segments. In univariate analysis the rate of correctly labelled tumor segments showed significant positive correlations to Gleason Score ≥7 and negative correlations to prostate weight and multifocularity. The rate of correctly labelled benign segments showed significant negative correlation to the tumor weight. All identified factors stayed independent influences in multivariate analysis. CONCLUSIONS Our data suggest that the reliability of endoMRI depends on clinical parameters. It is increasing with higher Gleason Scores, in case of unifocal tumors and in smaller prostate glands. These findings should be taken into account when interpreting endoMRI findings before decision-making regarding any type of local therapy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185 Issue 4S April 2011 Page: e926 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Metrics Author Information Daniela Colleselli Tuebingen, Germany More articles by this author Joerg Hennenlotter Tuebingen, Germany More articles by this author Stefan Krueger Tuebingen, Germany More articles by this author David Schilling Tuebingen, Germany More articles by this author Georgios Gakis Tuebingen, Germany More articles by this author Mathias Lichy Heidelberg, Germany More articles by this author Ulrich Vogel Tuebingen, Germany More articles by this author Ursula Kuehs Tuebingen, Germany More articles by this author Heinz-Peter Schlemmer Heidelberg, Germany More articles by this author Arnulf Stenzl Tuebingen, Germany More articles by this author Christian Schwentner Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...