julilili42/papers huggingface dataset:
H.E.S.S. and MAGIC observations of a sudden cessation of a very-high-energyγ-ray flare in PKS 1510−089 in May 2016
2021-01-04

The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E &gt; 100 GeV) γ rays. The VHE γ -ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ -ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ -ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R -band observations with ATOM revealed a counterpart of the γ -ray flare, even though the detailed flux evolution differs from the VHE γ -ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ -ray flare. In the high-energy (HE, E &gt; 100 MeV) γ -ray band, only a moderate flux increase was observed with Fermi -LAT, while the HE γ -ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ -ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock.
A field evidence model: how to predict transport in heterogeneous aquifers at low investigation level
2021-01-04

Abstract. Aquifer heterogeneity in combination with data scarcity is a major challenge for reliable solute transport prediction. Velocity fluctuations cause non-regular plume shapes with potentially long-tailing and/or fast-travelling mass fractions. High monitoring cost and a shortage of simple concepts have limited the incorporation of heterogeneity into many field transport models up to now. We present an easily applicable hierarchical conceptualization strategy for hydraulic conductivity to integrate aquifer heterogeneity into quantitative flow and transport modelling. The modular approach combines large-scale deterministic structures with random substructures. Depending on the modelling aim, the required structural complexity can be adapted. The same holds for the amount of monitoring data. The conductivity model is constructed step-wise following field evidence from observations, seeking a balance between model complexity and available field data. The starting point is a structure of deterministic blocks, derived from head profiles and pumping tests. Then, subscale heterogeneity in the form of random binary inclusions is introduced to each block. Structural parameters can be determined, for example, from flowmeter measurements or hydraulic profiling. As proof of concept, we implemented a predictive transport model for the heterogeneous MADE site. The proposed hierarchical aquifer structure reproduces the plume development of the MADE-1 transport experiment without calibration. Thus, classical advection–dispersion equation (ADE) models are able to describe highly skewed tracer plumes by incorporating deterministic contrasts and effects of connectivity in a stochastic way without using uni-modal heterogeneity models with high variances. The reliance of the conceptual model on few observations makes it appealing for a goal-oriented site-specific transport analysis of less well investigated heterogeneous sites.
Criegee Intermediates in Autoxidation Reactions: Mechanistic Considerations
2021-01-04

Products of Criegee intermediate (CI) chemistry were recently detected in radical chain autoxidation reactions involving β-hydroxyperoxy radicals. Here, we demonstrate by means of accurate G4 computations that direct scission of the latter to CIs and radical byproducts is thermodynamically highly unfavorable. Instead, the reaction becomes possible through a hydrogen abstraction reaction that could proceed by reversible formation of a dimeric tetroxide and a subsequent [1,6] hydrogen shift of the hydroxy hydrogen.
Giant planet migration during the disc dispersal phase
2021-01-04

Context. Transition discs are expected to be a natural outcome of the interplay between photoevaporation and giant planet formation. Massive planets reduce the inflow of material from the outer to the inner disc, therefore triggering an earlier onset of disc dispersal due to photoevaporation through a process known as Planet-Induced PhotoEvaporation. In this case, a cavity is formed as material inside the planetary orbit is removed by photoevaporation, leaving only the outer disc to drive the migration of the giant planet. Aims. We investigate the impact of photoevaporation on giant planet migration and focus specifically on the case of transition discs with an evacuated cavity inside the planet location. This is important for determining under what circumstances photoevaporation is efficient at halting the migration of giant planets, thus affecting the final orbital distribution of a population of planets. Methods. For this purpose, we use 2D FARGO simulations to model the migration of giant planets in a range of primordial and transition discs subject to photoevaporation. The results are then compared to the standard prescriptions used to calculate the migration tracks of planets in 1D planet population synthesis models. Results. The FARGO simulations show that once the disc inside the planet location is depleted of gas, planet migration ceases. This contradicts the results obtained by the impulse approximation, which predicts the accelerated inward migration of planets in discs that have been cleared inside the planetary orbit. Conclusions. These results suggest that the impulse approximation may not be suitable for planets embedded in transition discs. A better approximation that could be used in 1D models would involve halting planet migration once the material inside the planetary orbit is depleted of gas and the surface density at the 3:2 mean motion resonance location in the outer disc reaches a threshold value of 0.01 g cm ‒2 .
GestaltMatcher: Overcoming the limits of rare disease matching using facial phenotypic descriptors
2021-01-04

Abstract A large fraction of monogenic disorders causes craniofacial abnormalities with characteristic facial morphology. These disorders can be diagnosed more efficiently with the support of computer-aided next-generation phenotyping tools, such as DeepGestalt. These tools have learned to associate facial phenotypes with the underlying syndrome through training on thousands of patient photographs. However, this “supervised” approach means that diagnoses are only possible if the disorder was part of the training set. To improve recognition of ultra-rare disorders, we created GestaltMatcher, which uses a deep convolutional neural network based on the DeepGestalt framework. We used photographs of 17,560 patients with 1,115 rare disorders to define a “Clinical Face Phenotype Space”. Distance between cases in the phenotype space defines syndromic similarity, allowing test patients to be matched to a molecular diagnosis even when the disorder was not included in the training set. Similarities among patients with previously unknown disease genes can also be detected. Therefore, in concert with mutation data, GestaltMatcher could accelerate the clinical diagnosis of patients with ultra-rare disorders and facial dysmorphism, as well as enable the delineation of novel phenotypes.
Surface-plasmon-based dispersive detection and spectroscopy of ultracold atoms
2021-01-04

The paper reports on the optical detection and spectroscopy of ultracold\\natoms near a gold surface. A probe light field is used to excite surface\\nplasmon polaritons. The refractive index of the atomic gas shifts the plasmon\\nresonance and changes the reflected light power. Thus, the sensitivity of the\\ndetection is plasmonically enhanced. Absorption of photons from the evanescent\\nwave is avoided by detuning the laser from atomic resonance which makes the\\ndetection scheme potentially nondestructive. The spectrum of the signal is\\ndetermined by a Fano resonance. We show that atoms can be detected\\nnondestructively with single atom resolution for typical parameters in cold\\natom experiments. Thus, the method is suitable for quantum nondemolition\\nmeasurements of matter wave amplitudes. Experimentally, we measure a\\ntechnically-limited sensitivity of 30 atoms and extend the detection scheme to\\ndispersively image the atom cloud near the surface.\\n
Epidemiological analysis of 3,219 COVID-19 outbreaks in the state of Baden-Wuerttemberg, Germany.
2021-01-04

Abstract Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emerged as an unprecedented global crisis challenging health systems. The dynamic nature of the pandemic warrants ongoing characterisation and assessment of outbreak settings to identify groups at greatest risk, to establish early measures to curb transmission. The current analysis aims to assess and characterise SARS-CoV-2 outbreaks in the state of Baden-Wuerttemberg. Methods: We analysed all mandatory notified (i.e. laboratory-confirmed) coronavirus disease (COVID-19) outbreaks from the state of Baden-Wuerttemberg in calendar weeks 18 to 49 (from April 27 to December 06, 2020). We used the following classification for settings: asylum and refugee accommodation, care homes, care facilities, day care child centers, hobby related, hospitality, hospitals, households, other, residence halls, schools, supported housing, training schools, transportation, treatment facilities, and workplace (occupational). We used R program version 3.6.3 for analysis. Results: In the current analysis, 3,219 outbreaks with 22,238 individuals were included. Around 48% of all outbreaks in this period were in household settings and hobby related activities. We observed an exponential increase in the number of notified outbreaks starting around the 41th week with N = 291 outbreaks reported in week 49. We observed an increase in hospitalisations, and mortality associated with COVID-19 outbreaks in care homes after the 40th week. Overall, 70% (500/715) of all deceased persons in outbreaks in the study period were in care homes compared to 4.2% in household settings (30/715). Conclusions: The increase in the number of outbreaks and in the number of cases per outbreak in high-risk settings, specifically in care homes after the 40th week highlights the imperative of controlling transmission in vulnerable populations.
Life satisfaction in families with a child in an Unresponsive Wakefulness Syndrome
2021-01-04

Abstract Background: The article examines life conditions in families living together with a child in an Unresponsive Wakefulness Syndrome (UWS). Such families experience severe stress at financial, logistical, and existential level. Methods: We investigated a large sample of families living with a UWS child (comprising 13% of the total population) and compared these families with families without a chronically ill child. A set of four questionnaires aimed to evaluate life conditions entails a total of 204 items. One of the questionnaires was developed by the corresponding author specifically for this study. The questionnaires were positively accepted by the persons concerned and permitted us to test six specific hypotheses. Results: Life satisfaction (LS) in families with a UWS child was significantly lower than in control families. LS was significantly affected by external situational factors (everyday support, home visits, support by a doctor, nursing service, health insurance, etc.). Self-management skills were on average lower in families with a UWS child than in controls. These skills strongly and directly correlated with LS. Further, LS was not significantly related to the acceptance of feelings and negatively correlated with the floods of emotions. The relationship with the own child was equally satisfactory in families with and without a UWS child indicating that the families regard their UWS child as a full family member. Conclusions: The data show that happy life is possible in families living together with a UWS child. They further specify conditions for satisfactory life under multiple highly severe challenges. Personal self-management skills, coping strategies, and resilience, as well as outside social support, appear to be critical factors.
Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
2021-01-05

Precise and rapid identification and characterization of pathogens and antimicrobial resistance patterns are critical for the adequate treatment of infections, which represent an increasing problem in intensive care medicine. The current situation remains far from satisfactory in terms of turnaround times and overall efficacy. Application of an ineffective antimicrobial agent or the unnecessary use of broad-spectrum antibiotics worsens the patient prognosis and further accelerates the generation of resistant mutants. Here, we provide an overview that includes an evaluation and comparison of existing tools used to diagnose bacterial infections, together with a consideration of the underlying molecular principles and technologies. Special emphasis is placed on emerging developments that may lead to significant improvements in point of care detection and diagnosis of multi-resistant pathogens, and new directions that may be used to guide antibiotic therapy.
The First Prior: from Co-Embodiment to Co-Homeostasis in Early Life
2021-01-05

The idea that whatever we perceive now is influenced by whatever we perceived before lies at the core of Predictive Processing (PP) theories in philosophy and computational neuroscience. If this is so, then it becomes crucial to look at how perception, cognition and actions get off the ground from square one, in utero. Here we examine how humans self-regulate their homeostatic bodily states and build their most basic self- and world-model, literally through others’ bodies, in utero. Indeed, one basic yet overlooked aspect of current embodied and PP approaches is that brains (and minds), and human bodies, first develop within another human body. Crucially, while not all humans will have the experience of being pregnant or carrying a baby, the experience of being carried and growing within another person’s body is universal. Specifically, we define in utero development as a process co-embodiment and co-homeostasis, and highlight their close relationship. We show that the case of pregnancy offers a clear and fundamental example of co-embodiment, building upon theoretical and empirical work tackling the emergence of perceptual experiences in utero. We focus on pregnancy, a case where two individuating organisms literally grasp/ grip one into each other. Contrary to the common view of the foetus being passively ‘contained’ and solipsistically ‘trapped’ in the solitude of the womb, we will present evidence speaking in favour of an active and bidirectional co-regulation between the two living bodies, what we will call co-homeostasis. The co-embodiment and co-homeostasis theses will lay the preliminary ground for introducing a predictive processing reading of in utero development of perceptual experiences.We conclude that when it comes to understanding the nature of predictive perceptions, the infant is father to the human - to paraphrase the famous Wordsworth metaphor.
Choosing an activity that suits: development and validation of a questionnaire on motivational competence in exercise and sport
2021-01-05

Abstract The current study presents the development and validation of a questionnaire on motivational competence in exercise and sport. Motivational competence characterises the self-determined ability to choose a suitable exercise and sport activity. Knowing one’s own preferences and what to expect in different activities helps people to make this choice, which, in turn, supports them in maintaining their physical activity (PA) on a long-term and regular basis. The developed items cover the following three components of motivational competence: 1) knowing one’s own preferences, 2) knowing what to expect in different exercise and sport activities, and 3) choosing and arranging an exercise and sport activity. Psychometric properties were checked using a sample with N = 667 adults ( M age = 42.49, SD = 14.71, 62% female). The final one-dimensional scale consists of four items. Construct validity showed positive relationships to intrinsic and identified motivation modes of self-concordance and conversely no relationship to introjected and low negative to extrinsic motivation. For criterion validity, the structural equation modeling demonstrated that motivational competence and PA-specific self-control are independently and positively associated with exercise and sport behaviour. Overall, the newly developed scale is a psychometrically sound and economical instrument to be used in exercise and sport promotion (e.g. counselling) and research.
Mesoarchaean acidic volcanic lakes: A critical ecological niche in early land colonisation
2021-01-05

The antiquity of life in marine environments has been demonstrated, with examples of microfossils and stromatolites extending back to at least 3.5 billion years ago (Ga). In contrast, emerged land was likely a more challenging environment during the Archaean, and only sparse evidence of life in non-marine environments has so far been identified. Here we document the abundance of isotopically light carbon (with δ13C values from −46.6 to −31.3‰), diagnostic of a biogeochemical methane cycle or acetogenesis, in shale and sandstone deposited in ∼3 billion-years-old acidic volcanic lakes on the Kaapvaal Craton of southern Africa. A distinctive Al-rich mineral assemblage with abundant pyrophyllite in lacustrine sedimentary rocks bears similarity to modern volcanic rocks affected by circulation of hot acidic fluids. This is compounded with an enrichment of Ni, Mo, W, As and Cu in whole-rock analyses of sedimentary rocks, which is also observed in geothermal areas of modern volcanic environments. Analysis of early diagenetic pyrite in these sedimentary rocks indicates high nutrient level in the lake, which might reflect hydrothermal input with leaching of volcanic material. Despite the restricted and ephemeral nature of volcanic lakes, a highly productive and complex ecosystem established itself in this environment. Volcanic lakes during the Mesoarchaean thus served as an ecological niche for the development and diversification of microbial life on emerged continental landmasses.
Generation of Functional Vascular Endothelial Cells and Pericytes from Keratinocyte Derived Human Induced Pluripotent Stem Cells
2021-01-05

Human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) and pericytes provide a powerful tool for cardiovascular disease modelling, personalized drug testing, translational medicine, and tissue engineering. Here, we report a novel differentiation protocol that results in the fast and efficient production of ECs and pericytes from keratinocyte-derived hiPSCs. We found that the implementation of a 3D embryoid body (EB) stage significantly improves the differentiation efficiency. Compared with the monolayer-based technique, our protocol yields a distinct EC population with higher levels of EC marker expression such as CD31 and vascular endothelial cadherin (VE-cadherin). Furthermore, the EB-based protocol allows the generation of functional EC and pericyte populations that can promote blood vessel-like structure formation upon co-culturing. Moreover, we demonstrate that the EB-based ECs and pericytes can be successfully used in a microfluidic chip model, forming a stable 3D microvascular network. Overall, the described protocol can be used to efficiently differentiate both ECs and pericytes with distinct and high marker expression from keratinocyte-derived hiPSCs, providing a potent source material for future cardiovascular disease studies.
SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer’s disease
2021-01-05

Abstract In age-related neurodegenerative disease, like Alzheimer’s and Parkinson’s disease, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm- and human cell models for disease. Whether SERF modifies amyloid pathology in mammalian brain, however, has remained unknown. Here, we generated SERF2 brain-specific knockout mice which, unlike full body knockout mice, were viable, and showed no major behavioral and cognitive abnormalities. We combined these knockout mice with the APPPS1 mouse model for human amyloid beta aggregation. Using structure-specific amyloid dyes, previously used to distinguish amyloid polymorphisms in human brain, we show that knockout of SERF2 alters the structure of amyloid fibrils and deposits. Moreover, scanning transmission electron microscopy revealed thicker, shorter and more densely packed amyloid in absence of SERF2. Altogether, our data reveal pleiotropic functions of SERF in development and aging and support a function as a modifier of amyloid aggregation in mammalian brain. Our results indicate that single cellular factors like SERF can determine the structural outcome of amyloid aggregation, offering possibilities for polymorphism-based disease interventions.
Gesamtsprachliche Literaturdidaktik? Verhältnisbestimmungen zu klassischen Texten und literarischer Rezeptionsfähigkeit im gegenwärtigen Deutsch- und im Fremdsprachenunterricht
2021-01-05

The treatment of literary texts begins institutionally in kindergarten and in German lessons in elementary school. It is deepened and expanded in the secondary level through the addition of foreign languages. Against this background, as well as in the context of multilingualism and transculturality, the article asks which areas of overlap are necessary for an overall linguistic conception of literary aesthetic learning. Using curricular and literary didactic frameworks in the first and foreign language(s), the article also outlines the challenges that will arise in the future, also with a view to reading classic texts.