julilili42/papers huggingface dataset:
Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts
2018-05-22

Cystic echinococcosis (CE) is a globally endemic zoonosis caused by the larval stage of the Echinococcus granulosus sensu lato (s.l.) complex. Although the disease is known to be highly prevalent in certain parts of North and East Africa, data on CE, both in humans and definitive hosts, are extremely scarce for Central Africa. The present study assessed the epidemiology of CE in humans and dogs in rural Gabon. An ultrasound and serologic survey was conducted in volunteers from rural villages in Gabon. A two-step approach was used for serological testing with an indirect hemagglutination assay as a screening test and Western Blot as a confirmatory test. Fecal dog samples were analyzed microscopically, and polymerase chain reaction (PCR) amplification of nad1 and cox1 genes was performed when taeniid eggs were visible. Regional hospitals and the national reference center for parasitology in Gabon were contacted for information about previous cases of CE. Randomly selected communities were invited to participate. Three hundred and forty-eight human volunteers from these communities were screened. No suspected cases of CE were detected. Definitive host screening was performed from 128 fecal samples from representative subregions, but no eggs from E. granulosus s.l. were found. No documented cases of echinococcosis were reported from the local health-care institutions and the national diagnostic reference center in Gabon. Cystic echinococcosis seems to be very rare or absent in Gabon. The reason for this lack of evidence for echinococcosis is unknown, but the absence of livestock may play a major role.
Experimental and Geochemical Modeling Evidences of Mineral Sequestration of CO2 in Saline Siliciclastic aquifers
2018-05-22

The validity of mineral sequestration in saline siliciclastic aquifers in sedimentary basins is assessed in this paper. Mineral sequestration is the precipitation of carbonates due to the dissolution of silicates upon the injection of CO2 in deep geological formations, while solubility trapping is the dissolution of CO2 in the formation water. Saline reservoirs in sedimentary basins seem to constitute one of the best targets for the storage due to their huge storage capacity, low importance in terms of natural resources and wide availability and in close proximity to power generation plants. Siliciclastic aquifers are predicted to have the best potential for trapping CO2, by precipitating carbonate minerals, when they contain an assemblage of basic aluminosilicate minerals such as fledspars, zeolites, illites, chlorites and smectites. Precipitation of carbonate minerals due to the dissolution of silicate are generally not observed in laboratory experiments conducted at low temperature and pressure due to the slow dissolution rates of silicates, or the absence of significant amount of divalent cations in the rock composition. However, carbonate precipitation is observed in work conducted under relatively high pressure and temperature. On the other hand, although carbonate perception is predicted by computer simulation for larger timeframes as reported in several studies, yet laboratory and geochemical modeling work suggests that the injection of supercritical CO2 in deep saline aquifers may show limited reactivity with reservoir rocks. Thus, the dominant trapping mechanisms will be more based on the dissolution of CO2 in the formation water rather than on mineral sequestration. Accordingly, this article concludes that apart from the physical conditions such as temperature and pressure, mineral sequestration in saline siliciclastic aquifers of sedimentary basins may behave differently due to differences in brine compositions and rock types, and thus the degree of mineral sequestration is case specific.
Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates
2018-05-23

DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant DNA methylation patterns have been described in cancer. However, only a small fraction of differential methylation events target genes with a defined role in cancer, raising the question of how aberrant DNA methylation contributes to carcinogenesis. As recently a link has been suggested between methylation patterns arising in ageing and those arising in cancer, we asked which aberrations are unique to cancer and which are the product of normal ageing processes. We therefore compared the methylation patterns between ageing and cancer in multiple tissues. We observed that hypermethylation preferentially occurs in regulatory elements, while hypomethylation is associated with structural features of the chromatin. Specifically, we observed consistent hypomethylation of late-replicating, lamina-associated domains. The extent of hypomethylation was stronger in cancer, but in both ageing and cancer it was proportional to the replication timing of the region and the cell division rate of the tissue. Moreover, cancer patients who displayed more hypomethylation in late-replicating, lamina-associated domains had higher expression of cell division genes. These findings suggest that different cell division rates contribute to tissue- and cancer type-specific DNA methylation profiles.
Multicomponent Synthesis and Binding Mode of Imidazo[1,2-a]pyridine-Capped Selective HDAC6 Inhibitors
2018-05-23

The multicomponent synthesis of a mini-library of histone deacetylase inhibitors with imidazo[1,2- a]pyridine-based cap groups is presented. The biological evaluation led to the discovery of the hit compound MAIP-032 as a selective HDAC6 inhibitor with promising anticancer activity. The X-ray structure of catalytic domain 2 from Danio rerio HDAC6 complexed with MAIP-032 revealed a monodentate zinc-binding mode.
Robust Perception through Analysis by Synthesis.
2018-05-23

Despite much effort, deep neural networks remain highly susceptible to tiny input perturbations and even for MNIST, one of the most common toy datasets in computer vision, no neural network model exists for which adversarial perturbations are large and make semantic sense to humans. We show that even the widely recognized and by far most successful defense by Madry et al. (1) overfits on the L-infinity metric (it's highly susceptible to L2 and L0 perturbations), (2) classifies unrecognizable images with high certainty, (3) performs not much better than simple input binarization and (4) features adversarial perturbations that make little sense to humans. These results suggest that MNIST is far from being solved in terms of adversarial robustness. We present a novel robust classification model that performs analysis by synthesis using learned class-conditional data distributions. We derive bounds on the robustness and go to great length to empirically evaluate our model using maximally effective adversarial attacks by (a) applying decision-based, score-based, gradient-based and transfer-based attacks for several different Lp norms, (b) by designing a new attack that exploits the structure of our defended model and (c) by devising a novel decision-based attack that seeks to minimize the number of perturbed pixels (L0). The results suggest that our approach yields state-of-the-art robustness on MNIST against L0, L2 and L-infinity perturbations and we demonstrate that most adversarial examples are strongly perturbed towards the perceptual boundary between the original and the adversarial class.
Deriving micro- to macro-scale seismic velocities from ice-core c axis orientations
2018-05-23

Abstract. One of the great challenges in glaciology is the ability to estimate the bulk ice anisotropy in ice sheets and glaciers, which is needed to improve our understanding of ice-sheet dynamics. We investigate the effect of crystal anisotropy on seismic velocities in glacier ice and revisit the framework which is based on fabric eigenvalues to derive approximate seismic velocities by exploiting the assumed symmetry. In contrast to previous studies, we calculate the seismic velocities using the exact c axis angles describing the orientations of the crystal ensemble in an ice-core sample. We apply this approach to fabric data sets from an alpine and a polar ice core. Our results provide a quantitative evaluation of the earlier approximative eigenvalue framework. For near-vertical incidence our results differ by up to 135 m s−1 for P-wave and 200 m s−1 for S-wave velocity compared to the earlier framework (estimated 1 % difference in average P-wave velocity at the bedrock for the short alpine ice core). We quantify the influence of shear-wave splitting at the bedrock as 45 m s−1 for the alpine ice core and 59 m s−1 for the polar ice core. At non-vertical incidence we obtain differences of up to 185 m s−1 for P-wave and 280 m s−1 for S-wave velocities. Additionally, our findings highlight the variation in seismic velocity at non-vertical incidence as a function of the horizontal azimuth of the seismic plane, which can be significant for non-symmetric orientation distributions and results in a strong azimuth-dependent shear-wave splitting of max. 281 m s−1 at some depths. For a given incidence angle and depth we estimated changes in phase velocity of almost 200 m s−1 for P wave and more than 200 m s−1 for S wave and shear-wave splitting under a rotating seismic plane. We assess for the first time the change in seismic anisotropy that can be expected on a short spatial (vertical) scale in a glacier due to strong variability in crystal-orientation fabric (±50 m s−1 per 10 cm). Our investigation of seismic anisotropy based on ice-core data contributes to advancing the interpretation of seismic data, with respect to extracting bulk information about crystal anisotropy, without having to drill an ice core and with special regard to future applications employing ultrasonic sounding.
Significant acceleration of emergency response using smartphone geolocation data and a worldwide emergency call support system
2018-05-23

&lt;div&gt;&lt;p&gt;Importance&lt;/p&gt;&lt;p&gt;When patients are disorientated or experience language barriers, it is impossible to activate the emergency response system. In these cases, the delay for receiving appropriate help can extend to several hours.&lt;/p&gt;&lt;p&gt;Objectives&lt;/p&gt;&lt;p&gt;A worldwide emergency call support system (ECSS), including geolocation of modern smartphones (GPS, WLAN and LBS), was established referring to E911 and eCall systems. The system was tested for relevance in quickly forwarding abroad emergency calls to emergency medical services (EMS).&lt;/p&gt;&lt;p&gt;Design&lt;/p&gt;&lt;p&gt;To verify that geolocation data from smartphones are exact enough to be used for emergency cases, the accuracy of GPS (global positioning system), Wi-Fi (wireless LAN network) and LBS (location based system) was tested in eleven different countries and compared to actual location. The main objective was analyzed by simulation of emergencies in different countries. The time delay in receiving help in unsuccessful emergency call cases by using the worldwide emergency call support system (ECSS) was measured.&lt;/p&gt;&lt;p&gt;Results&lt;/p&gt;&lt;p&gt;GPS is the gold standard to locate patients with an average accuracy of 2.0 ± 3.3 m. Wi-Fi can be used within buildings with an accuracy of 7.0 ± 24.1 m. Using ECSS, the emergency call leads to a successful activation of EMS in 22.8 ± 10.8 min (Median 21 min). The use of a simple app with one button to touch did never cause any delay.&lt;/p&gt;&lt;p&gt;Conclusions and relevance&lt;/p&gt;&lt;p&gt;The worldwide emergency call support system (ECSS) significantly improves the emergency response in cases of disorientated patients or language barriers. Under circumstances without ECSS, help can be delayed by 2 or more hours and might have relevant lifesaving effects. This is the first time that Wi-Fi geolocation could prove to be a useful improvement in emergencies to enhance GPS, especially within or close to buildings.&lt;/p&gt;&lt;/div&gt;
Use of Capillary Blood Samples Leads to Higher Parasitemia Estimates and Higher Diagnostic Sensitivity of Microscopic and Molecular Diagnostics of Malaria Than Venous Blood Samples
2018-05-23

CAP sampling leads to higher parasitemias compared to VEN sampling and improves diagnostic sensitivity. These findings may have important implications for routine diagnostics, research, and elimination campaigns of malaria.
Major depression – a study on the validity of clinicians’ diagnoses in medicolegal assessment
2018-05-23

Major depression ranges among the most frequently diagnosed psychiatric disorders. Accordingly, diagnoses of depression are often underlying insurance, compensation or disability claims. This report evaluates the validity of clinicians' diagnoses of major depression in a sample of claimants. In 2015, n = 127 consecutive cases were examined for medicolegal assessment. For all of them, a diagnosis of major depression had been established by clinicians. All testees underwent a psychiatric interview, a physical examination, they answered questionnaires for depressive symptoms according to DSM-5, embitterment disorder, post concussion syndrome (PCS) and unspecific somatic complaints. Performance and symptom validity tests were administered. Only 31% fulfilled the diagnostic criteria for DSM-5 major depression according to self-report, while none did so according to psychiatric assessment. Negative response bias was found in 64% of cases, feigned neurologic symptoms in 22%. Symptom exaggeration was indiscriminate rather than depression-specific. By self-report, 64% of the participants qualified for embitterment disorder and 93% for PCS. In conclusion, clinicians' diagnoses of depression seem often confounded by improper assessment of the diagnostic criteria, confusion of depression with bereavement or embitterment and also by response bias.
Institutionalising Morality: The UN Security Council and the Fundamental Norms of the International Legal Order
2018-05-23

This chapter considers the relationship between international law and the role and practice of the UN Security Council. Proceeding from the assumption that all international organizations are constituted, constrained, and empowered by the fundamental moral principles of the international legal order, it explores the way in which the norms of jus cogens have shaped the Security Council's institutional environment and practice. It suggests that as a manifestation of the moral principles of international law, jus cogens norms have forged and defined the SC beyond the legal framework set out in the UN Charter. At the same time, it shows that the content and relevance of jus cogens itself have been shaped through Security Council successes and failures.
Foliations by spheres with constant expansion for isolated systems without asymptotic symmetry
2018-05-23

Motivated by the foliation by stable spheres with constant mean curvature constructed by Huisken-Yau, Metzger proved that every initial data set can be foliated by spheres with constant expansion (CE) if the manifold is asymptotically equal to the standard [t=0]-timeslice of the Schwarzschild solution. In this paper, we generalize his result to asymptotically flat initial data sets and weaken additional smallness assumptions made by Metzger. Furthermore, we prove that the CE-surfaces are in a well-defined sense (asymptotically) independent of time if the linear momentum vanishes.
Dephasing effects on ac-driven triple quantum dot systems
2018-05-23

We analyze the effect of environmental dephasing on the electrical current in an ac-driven triple quantum dot system in a symmetric configuration. The current is explored by solving the time evolution equation of the density matrix as a function of the frequency and amplitude of the driving field. Two characteristic spectra are observed depending on the field amplitude. At the resonance condition, when the frequency matches the interdot energy difference, one spectrum shows a distinctive Fano-type peak, while the other, occurring at larger values of the field amplitude, exhibits a strong current suppression due to dynamic localization. In the former case we observe that the current maximum is reduced due to dephasing, while in the latter it is shown that dephasing partially alleviates the localization. In both cases, away from resonance, we observe current oscillations which are dephasing-enhanced for a wide range of frequencies. These effects are also discussed using Floquet theory, and analytical expressions for the electrical current are obtained within the rotating wave approximation.
Femtosecond and Attosecond Electron-Transfer Dynamics in PCPDTBT:PCBM Bulk Heterojunctions
2018-05-24

Charge separation efficiency is a crucial parameter for photovoltaic devices-polymers consisting of alternating electron-rich and electron-deficient parts can achieve high such efficiencies, for instance, together with a fullerene electron acceptor. This offers a viable path toward solar cells with organic bulk heterojunctions. Here, we measured the charge-transfer times in the femtosecond and attosecond regimes via the decay of sulfur is X-ray core excited states (with the core-hole clock method) in blends of a low-band gap polymer {PCPDTBT [poly[2,6-(4,4-bis (2-ethylhexyl)-4H-cyclopenta [2,1-b;3,4-1/1 dithiophene)-alt-4,7- (2,1,3-benzothiadiazole)]]} consisting of a cyclopentadithiophene electron-rich part and a benzothiadiazole electron-deficient part. The constituting parts of the bulk heterojunction were varied by adding the fullerene derivative PCBM ([6,6]-phenyl-C-61-butyric acid methyl ester) (weight ratio of polymer/PCBM as 1:0, 1:1, 1:2, and 1:3). For low-energy excitations, the charge-transfer time varies to the largest extent for the thiophene donor part. The charge-transfer time in the 1:2 blend is reduced by 86% compared to that of pristine PCPDTBT. At higher energy excitations, the charge-transfer time does not vary with the chemical environment, as this regime is dominated by intramolecular conduction that yields ultrafast charge-transfer times for all blends, approaching 170 as. We thus demonstrate that the core-hole clock method applied to a series with changing composition can give information about local electron dynamics (with chemical specificity) at interfaces between the constituting parts the crucial part of a bulk heterojunction where the initial charge separation occurs.
In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract
2018-05-24

Several species of the genus <i>Ceiba</i> (Malvaceae) are ethnopharmacologically used. Thus, this study aimed to investigate the <i>in vitro</i> beneficial properties of the aqueous stem bark extract of <i>Ceiba speciosa</i>. The extract presented a great amount of phenolic compounds (117.4 ± 6.2 mg GAE/g). The antioxidant activity was assessed by DPPH (IC<sub>50</sub> = 42.87 μg/mL), ORAC (2351.17 μmol TE/g) and FRAP (235.94 μM FeSO<sub>4</sub>/g) methods. In addition, the extract reduced MCF-7 cell viability as assessed by MTT. However, it prevented mitochondrial membrane depolarization and reduced caspase-9 activity induced by hydrogen peroxide. In conclusion, these findings indicate the extract is an excellent source of natural antioxidants and is able to protect ROS-induced cell death. Therefore, <i>C. speciosa</i> extract may possess beneficial properties for application in pharmaceutical industry as an antioxidant. However, further studies to better elucidate its mechanisms and to isolate its active compounds are required.
Urban Factionalism in Late Ottoman Gaza, c. 1875-1914: Local Politics and Spatial Divisions
2018-05-24

Abstract During the late Ottoman period the city of Gaza was caught up in internal political strife. The city’s elite families tended to operate within rival factions while trying to draw Istanbul into its internal conflicts. In this context, they formed complex relationships with the elite of Jerusalem that dominated Palestine’s politics, as well as with peasants and Bedouins in Gaza’s hinterland. The article presents the first systematic account of factional strife in Gaza during the period. In addition, it examines what caused the internal divisions in Gaza to be so severe and considers whether factionalism also played out in the urban space. It is argued that (1) the severity of this factionalism derived from the rising stakes resulting from imperial politics and economic benefits, and (2) factionalism and urban development interacted with each other, leading to a particular type of ‘spatialized factionalism’. We suggest that this perspective can lead to a better understanding of both urban politics and urban development in other towns and cities in the Ottoman Empire’s Arab provinces.
Willingness to pay for a cure of low-risk melanoma patients in Germany
2018-05-24

Malignant melanoma is potentially life-threatening but in most cases curable if detected early. Willingness to pay (WTP) is a preference-based construct that reflects burden of disease by assessment of the monetary value for a hypothetical cure from disease. Since WTP (directly as total amount of money) has not been assessed so far in patients with low risk melanoma, it was interesting to gain insights in this patient population and then, in a second step, compare it directly with the WTP of their treating dermato-oncologists. WTP was assessed in 125 patients with low-risk melanoma and additionally in 105 treating physicians, asking for the one-time and continuous payments they would be willing to make for a sustainable cure, both as absolute sums and as percentages of monthly income. The median WTP based on one-time payment was €10,000 for patients and €100,000 for physicians; relative numbers were 100% versus 300% of monthly income. For continuous monthly payments, WTP was €500 for patients and €1000 for physicians, relative numbers 25% and 50% of income, respectively. Even after controlling for income differences, there was a significantly higher WTP in physicians for all four questions. Compared to patients with chronic skin diseases such as vitiligo, rosacea, atopic eczema and psoriasis, patients with low-risk melanoma showed a significantly higher WTP. Our data suggest that there is a relevant burden of disease even in patients with low-risk tumors. Higher WTP of physicians underlines the prevalence of differences in disease perception.