Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy People
2003-11-18

Letters18 November 2003Association of High Serum Ferritin Concentration with Glucose Intolerance and Insulin Resistance in Healthy PeopleMichael Haap, MD, Andreas Fritsche, MD, Heinz Joachim Mensing, MD, Hans-Ulrich Hring, MD, and Michael Stumvoll, MDMichael Haap, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Andreas Fritsche, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Heinz Joachim Mensing, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Hans-Ulrich Hring, MDFrom University of Tbingen; D-72076 Tbingen, Germany., and Michael Stumvoll, MDFrom University of Tbingen; D-72076 Tbingen, Germany.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-10-200311180-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Increasing evidence points to an association between increased body iron storage and type 2 diabetes mellitus, even outside the context of hemochromatosis (1, 2). A small intervention study provided preliminary evidence that bloodletting, which resulted in 50% reduction of serum ferritin concentrations, improved glycemia and insulin sensitivity in patients with type 2 diabetes (3). However, interpretation of mechanistic studies in patients with overt type 2 diabetes mellitus are complicated because glycemic control itself influences serum ferritin concentrations (glycosylated ferritin has a longer serum half-life) and primary effects on insulin sensitivity or -cell function can no longer ...References1. Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, . Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes Care. 1997;20:426-8. [PMID: 9051399] CrossrefMedlineGoogle Scholar2. Ford ES, Cogswell ME. Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care. 1999;22:1978-83. [PMID: 10587829] CrossrefMedlineGoogle Scholar3. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and -cell function. Diabetes. 2002;51:1000-4. [PMID: 11916918] CrossrefMedlineGoogle Scholar4. Ferrannini E. Insulin resistance, iron, and the liver. Lancet. 2000;355:2181-2. [PMID: 10881887] CrossrefMedlineGoogle Scholar5. Qian M, Liu M, Eaton JW. Transition metals bind to glycated proteins forming redox active glycochelates: implications for the pathogenesis of certain diabetic complications. Biochem Biophys Res Commun. 1998;250:385-9. [PMID: 9753639] CrossrefMedlineGoogle Scholar6. Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51:2348-54. [PMID: 12145144] CrossrefMedlineGoogle Scholar7. Resnick HE, Howard BV. Diabetes and cardiovascular disease. Annu Rev Med. 2002;53:245-67. [PMID: 11818473] CrossrefMedlineGoogle Scholar8. Hua NW, Stoohs RA, Facchini FS. Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians. Br J Nutr. 2001;86:515-9. [PMID: 11591239] CrossrefMedlineGoogle Scholar9. Kato I, Dnistrian AM, Schwartz M, Toniolo P, Koenig K, Shore RE, . Risk of iron overload among middle-aged women. Int J Vitam Nutr Res. 2000;70:119-25. [PMID: 10883405] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Tbingen; D-72076 Tbingen, Germany.Grant Support: In part by grants from the Deutsche Forschungsgemeinschaft DFG (Stu 192/3-1 and FR 1561/1-1) and the European Union (QLRT-1999-00674). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlbuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic SyndromeKidney Adaptations Prevent Loss of Trace Elements in Wistar Rats with Early Metabolic SyndromeHyperferritinemia—A Clinical OverviewAssociations of serum iron and ferritin with hyperuricemia and serum uric acidAssociations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition SurveyDevelopment of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat dietEnhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk Prediction of Glucose Tolerance without an Oral Glucose Tolerance TestIron in red meat–friend or foeMetabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolismPresence of Serum Ferritin before and after Bariatric Surgery: Analysis in Dentate and Edentulous PatientsAssociation of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct StudyPositive correlation between insulin resistance and iron overload-induced oxidative stress in patients with fanconi anemia (FA)- and non-FA-related bone marrow failure: The results of a multicenter studySerum ferritin and glucose homeostasis: change in the association by glycaemic stateIron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM studyFasting serum levels of ferritin are associated with impaired pancreatic beta cell function and decreased insulin sensitivity: a population-based studySerum Ferritin, Insulin Resistance, and Metabolic Syndrome: Clinical and Laboratory Associations in 769 Non-Hispanic Whites Without Diabetes Mellitus in the HEIRS StudyIron homeostasis: a new job for macrophages in adipose tissue?Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesisFine-tuned iron availability is essential to achieve optimal adipocyte differentiation and mitochondrial biogenesisInsulin Resistance Modulates Iron-Related Proteins in Adipose TissueHigh Serum Ferritin Levels Increase the Risk of Hyperuricemia: A Cross-Sectional and Longitudinal StudyElevated Ferritin Levels and the Relationship with Fasting Insulin Levels in Elderly Patients with Metabolic SyndromeEffects of excess dietary iron and fat on glucose and lipid metabolismSerum hepcidin is associated with parameters of glucose metabolism in women with gestational diabetes mellitusSerum ferritin is associated with markers of insulin resistance in Japanese men but not in womenResolving the effects of albumin glycation using the quartz crystal microbalanceDietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysisSerum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean menCoffee and Type 2 Diabetes RiskAssociation of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeysThe link between iron, metabolic syndrome, and Alzheimer's diseaseAssociation of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and womenIron overload in nonalcoholic steatohepatitisRelation between serum high molecular weight adiponectin and serum ferritin or prohepcidin in patients with type 2 diabetesDisorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot studyGlucose abnormalities in non-alcoholic fatty liver disease and chronic hepatitis C virus infection: the role of iron overloadThe role of iron in type 2 diabetes in humansIron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidinRole of hepatic iron in non-alcoholic steatohepatitisElevated Concentrations of Liver Enzymes and Ferritin Identify a New Phenotype of Insulin Resistance: Effect of Weight Loss After Gastric BandingSurcharges en fer d'origine génétique et hépatosidérose dysmétaboliqueFactors accounting for high ferritin levels in obesityElevated serum ferritin concentrations in prediabetic subjectsHepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis CStudy of iron metabolism disturbances in an animal model of insulin resistanceHigh Iron Stores and Impaired Endothelial Function in Prediabetic SubjectsHepatitis C infection and diabetesHyperglycosylated ferritin in sera of HIV-1-infected patients treated with highly active antiretroviral therapyGastrointestinal Complications of Diabetes MellitusIron and insulin resistanceBody Iron Stores Are Increased in Overweight and Obese Women With Polycystic Ovary SyndromeIron Stores, Blood Donation, and Insulin Sensitivity and SecretionDiabetes Is the Main Factor Accounting for the High Ferritin Levels Detected in Chronic Hepatitis C Virus InfectionSerum Ferritin and Risk of the Metabolic Syndrome in U.S. Adults 18 November 2003Volume 139, Issue 10Page: 869-871KeywordsAttentionFerritinGlucoseInsulin resistanceLinear regression analysisMedical risk factorsOral glucose tolerance testPathogenesisSerum ferritin levelsType 2 diabetes ePublished: 18 November 2003 Issue Published: 18 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...