julilili42/papers huggingface dataset:
Data reduction and exact algorithms for clique cover
2008-10-07

To cover the edges of a graph with a minimum number of cliques is an NP-hard problem with many applications. For this problem we develop efficient and effective polynomial-time data reduction rules that, combined with a search tree algorithm, allow for exact problem solutions in competitive time. This is confirmed by experiments with real-world and synthetic data. Moreover, we prove the fixed-parameter tractability of covering edges by cliques.
A practical and transferable new protocol for treadmill testing of children and adults*
2008-10-07

Abstract Background It is just as vital to have an exact overview of the physical fitness of young and growing people as it is for adults. The currently used exercise protocols have limitations in healthy small children, and in senior citizens. In particular with chronically ill patients, regardless of their age, there is a need for an exercise protocol that permits observations over the long term. With this need in mind, we have designed a new transferable standardised exercise protocol, constructing reference values based on improved assessments on a treadmill that permitted stepwise increases of speed and gradient every 90 seconds – the so called treadmill protocol from the German Society of Paediatric Cardiology. Objectives We investigated the exercise performance in a healthy Caucasian population ranging in age from 4 to 75 years. Methods We measured, using a prospective study design, the distance run, the endurance, and the consumption of oxygen in 548 females and 647 males undergoing an enhanced spiroergometric treadmill protocol in two centres. Results and conclusions Until puberty, boys and girls have the same indicators of exercise performance. Subsequent to puberty, uptake of oxygen and distance run differ, with males showing higher uptake of oxygen. There is still an age-dependent dynamic of peak uptake of oxygen related to body surface area. Using these new reference values, covering the whole range of age, it proves possible to compare performance during growth and aging of the individual. In this fashion, we have calculated centiles for all recorded variables. External calibration, validation and quality control ensures transferability of our data to other spiroergometry units.
Cortical Activations in Humans Grasp-Related Areas Depend on Hand Used and Handedness
2008-10-09

Data are discussed in terms of an handedness-independent role for the right dPMC in monitoring hand shaping, the need for bilateral AIP activity for the performance of precision grip movements which varies depending on handedness and the involvement of the cerebellum in terms of its connections with AIP. These results provide the first compelling evidence of specific grasping related neural activity depending on handedness.
Characterization of 14 polymorphic microsatellite loci for the facultatively eusocial sweat bee Halictus rubicundus (Hymenoptera, Halictidae) and their variability in related species
2008-10-10

Abstract Sweat bees display considerable variation in social organization and a few species, such as Halictus rubicundus , are even facultatively eusocial. Fourteen polymorphic, unlinked microsatellite loci were isolated from H. rubicundus and characterized in 45 females. The number of alleles per locus ranged from two to 18 (mean 10.1), observed heterozygosity ranged from 0.24 to 0.98 (mean 0.71) and expected heterozygosity ranged from 0.24 to 0.98 (mean 0.70). Six or more loci cross‐amplified in four other sweat bees. These loci will be useful for the study of social evolution and population genetic structure in H. rubicundus and many other sweat bees.
ChemInform Abstract: Biaryl Formation from 5‐(2‐Bromobenzyl)‐Substituted Piperidin‐2‐ones via Palladacycles.
2008-10-10

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sun protection by red wine?
2008-10-11

Summary Background : There is increasing evidence that polyphenols, antioxidants from plants such as green tea or grapes, may impair the UV‐induced erythema reaction as well as carcinogenesis and metastasis of melanoma and epithelial skin cancer. The UVB‐protective potential of wine polyphenols has not been studied so far in humans. Patients and Methods : We tested the influence of local and systemic application of three red wines on the minimal erythema dose (MED) after UVB exposure in 15 healthy male physicians. Baseline MED were determined in all subjects. Irradiation was carried out prior to and immediately following 20 minutes of occlusive application of red wine as well as 12 % alcohol to the back. The systemic effect was tested by ultraviolet irradiation immediately prior to oral intake, Results : There were no topical effects. Wine A also provided no protection sys‐temically. Drinking wine B has led to an almost significant rise of MED, while wine C, which had the highest polyphenol content, produced a statistically significant higher MED (p = 0.031). Conclusions : “Wine baths” will not have sun protective properties. A significant rise of the MED following oral intake of the wine with the highest polyphenol content might be due to these substances. Further research is needed to clarify the role of polyphenol content, dose and duration of wine consumption.
Unsymmetrical Biaryls by Palladium‐Catalyzed Coupling of Aryl Halides with Internal Reduction
2008-10-11

Abstract Aryl bromides containing a (1,4,5,6‐tetrahydro‐6‐oxopyridin‐3‐yl)methyl substituent can be coupled with aryl halides yielding unsummetrical biaryls. In the course of this process, the cyclic enamide is oxidized to the 2(1 H )‐pyridinone. The reaction proceeds by a six‐membered palladacycle resulting from allylic C–H bond activation of the cyclic enamide, leading to a six‐membered palladacycle. A subsequent transmetalation reaction with an aryl‐Pd‐X intermediate eventually leads to mixed biaryls by reductive elimination and β‐hydride elimination. The best yields were obtained with 2 equiv. of aryl halide. The required substrates were prepared from bromoiodobenzenes by a sequence consisting of a Heck reaction with allyl alcohol, enamine formation, Michael addition to ethyl acrylate, and heterocycle formation with benzylamine.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Neurotoxic lesion of the rostral perirhinal cortex blocks stress-induced exploratory behavioral changes in male rats
2008-10-11

Exposure to stress leads to adaptive responses including both behavioral and physiological changes. This process is induced by the activation of multiple brain regions. The present study examined the role of the rostral perirhinal cortex (rPRh) in behavioral changes following electrical foot shock-induced stress. The rPRh of rats was lesioned bilaterally by local microinjections of 10 microg N-methyl-D-aspartic acid (NMDA) before foot shocks (0.7 mA, 1 s). The effects of these lesions on foot shock-induced changes in exploratory behaviors were tested in the open field (4 h, 48 h, 72 h, and 14 days after foot shocks) and the light-dark box (7 days after foot shocks). Foot-shocked and sham-lesioned rats showed several well known behavioral changes in the open field (e.g., immobility, reduction of exploratory activity) most marked at 48 h after foot shocks, and the light-dark box (e.g., reduction of time spent and activity in the lit compartment). All these stress-induced behavioral changes were blocked by neurotoxic lesions of the rPRh. Furthermore, rPRh lesions did not affect behavior in the open field and the light-dark box in unstressed rats. Taken together, these data indicate that the rPRh is involved in neurophysiological mechanisms that mediate changes induced by foot-shock stress in exploratory behaviors which indicate unconditioned fear or anxiety.
Pressure gradients, shell-crossing singularities and acoustic oscillations – application to inhomogeneous cosmological models
2008-10-13

Abstract Inhomogeneous cosmological models have recently become a very interesting alternative to standard cosmology. This is because these models are able to fit cosmological observations without the need for dark energy. However, due to inhomogeneity and pressureless matter content, these models can suffer from shell-crossing singularities. These singularities occur when two shells of dust collide with each other leading to infinite values of the density. In this Letter, we show that if inhomogeneous pressure is included then these singularities can be prevented from occurring over the period of structure formation. Thus, a simple incorporation of a gradient of pressure allows for more comprehensive studies of inhomogeneous cosmological models and their application to cosmology.
A novel mutation in the FOXC1 gene in a family with Axenfeld–Rieger syndrome and Peters’ anomaly
2008-10-13

Peters anomaly and Axenfeld–Rieger syndrome (ARS) belong to the overlapping spectrum of disorders summarized as anterior segment dysgenesis (ASD). Five patients from a family with Peters’ anomaly and ARS were screened for mutations in the PITX2 , CYP1B1 and FOXC1 genes by direct sequencing. All affected family members examined were heterozygous for a single nucleotide substitution, resulting in a nonsense mutation (Q120X) at a highly conserved residue of the FOXC1 gene that is essential for DNA binding. In this pedigree, all affected family members were diagnosed with ARS except for one who shows bilateral Peters’ anomaly. Our findings support the role of FOXC1 mutations in the spectrum of ASD.
FAY‐NE15 — Another Neolithic graveyard in the Central Region of the Sharjah Emirate?
2008-10-13

The paper describes indications for the existence of another substantial Neolithic graveyard of the fifth millennium BC besides al‐Buhais 18 (BHS18) in the Central Region of the Sharjah Emirate. Archaeological explorations in 2006 recovered skeletal remains of three individuals from a primary burial. Deposition of the deceased was similar to BHS18. All three were richly adorned with different kinds of beads found in the head and neck areas. A total of 949 finds of beads from FAY‐NE15 are compared to the large complex of personal adornments from BHS18. There are slight deviations that might indicate that the two graveyards were used by different groups. Implications for the relations between the groups are discussed.
High-Performance Liquid Chromatographic Quantitative Determination of Amcinonide and Benzyl Alcohol in Pharmaceutical Preparations
2008-10-13

This paper describes a simple, precise, and validated high-performance liquid chromatographic method for the simultaneous quantitative determination of amcinonide and benzyl alcohol in pharmaceutical preparations.The separation was achieved using a Zorbax reversed-phase column (5 m, 250x4.6mm)at room temperature with an isocratic mixture of deionized water and acetonitrile (70:30 v/v) at a flow rate of 1.5ml/min and detection at 254 nm.The limits of quantification for amcinonide and benzyl alcohol were found to be 4-30 g/ml and 80-600 g/ml, respectively.The validity of the method was evaluated in terms of linear regression analysis, precision, specificity, accuracy and ruggedness.The developed methodology is an economic, time-saving, straight forward and precise assay for the determination of amcinonide and benzyl alcohol in pharmaceutical preparations.It can be readily utilized for quality assurance and R&D laboratories of pharmaceutical and cosmetic industry.
Impact of genotype and mutation type on health-related quality of life in patients with hereditary hemorrhagic telangiectasia
2008-10-14

HHT2 patients (genotype ALK-1) demonstrated significantly higher physical component scores than HHT1 patients (effect size d=0.62). Patients with genotype ENG (HHT1) with nonsense mutations showed significantly higher mental component scores than patients with missense mutations (effect size=0.79).
Synthesis and Characterization of the Platinum(IV) Hydride [PtH(SnB11H11)5]7−
2008-10-14

The square-planar platinum(II) compound [Pt(SnB11H11)4]6− can be readily protonated in the presence of stanna-closo-dodecaborate, resulting in the formation of the octahedral platinum(IV) compound [PtH(SnB11H11)5]7−. When this reaction is carried out with DCl, the corresponding deuteride derivative [PtD(SnB11H11)5]7− can be obtained.
Decoding of Individuated Finger Movements Using Surface Electromyography
2008-10-15

Upper limb prostheses are increasingly resembling the limbs they seek to replace in both form and functionality, including the design and development of multifingered hands and wrists. Hence, it becomes necessary to control large numbers of degrees of freedom (DOFs), required for individuated finger movements, preferably using noninvasive signals. While existing control paradigms are typically used to drive a single-DOF hook-based configurations, dexterous tasks such as individual finger movements would require more elaborate control schemes. We show that it is possible to decode individual flexion and extension movements of each finger (ten movements) with greater than 90% accuracy in a transradial amputee using only noninvasive surface myoelectric signals. Further, comparison of decoding accuracy from a transradial amputee and able-bodied subjects shows no statistically significant difference ( p < 0.05) between these subjects. These results are encouraging for the development of real-time control strategies based on the surface myoelectric signal to control dexterous prosthetic hands.
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1
2008-10-15

Abstract Introduction Breast tumors lacking the estrogen receptor-α (ER-α) have increased incidence of resistance to therapy and poorer clinical prognosis. Methods Whole tissue sections from 16 cryopreserved breast cancer tumors that were either positive or negative for the ER (eight ER positive and eight ER negative) were differentially analyzed by multiplex imaging of two-dimensional PAGE gels using 54 cm isoelectric focusing. Differentially detected spots of Progesterone Receptor Membrane Component 1 (PGRMC1) were shown to differ in phosphorylation status by differential two dimensional polyacrylamide gel electrophoresis of phosphatase-treated tumor proteins. Site directed mutagenesis was used to create putative phosphorylation site point mutants in PGRMC1. Stable transfectants of these mutants in MCF7 cells were assayed for their survival after oxidative stress, and for AKT kinase phosphorylation. Immune fluorescence using anti-PGRMC1 monoclonal antibody 5G7 was performed on breast cancer tissue microarrays. Results Proteins significantly differentially abundant between estrogen receptor negative and estrogen receptor positive tumors at the 0.1% level were consistent with published profiles, suggesting an altered keratin pool, and increased inflammation and wound responses in estrogen receptor negative tumors. Two of three spots of PGRMC1 were more abundant in estrogen receptor negative tumors. Phosphatase treatment of breast tumor proteins indicated that the PGRMC1 isoforms differed in their phosphorylation status. Simultaneous mutation of PGRMC1 serine-56 and serine-181 fully abrogated the sensitivity of stably transfected MCF7 breast cancer cells to peroxide-induced cell death. Immune fluorescence revealed that PGRMC1 was primarily expressed in ER-negative basal epithelial cells of mammary ductules. Even in advanced tumors, high levels of ER or PGRMC1 were almost mutually exclusive in individual cells. In five out of five examined ductal in situ breast cancers of comedo type, PGRMC1 was expressed in glucose transporter 1 negative or positive poorly oxygenated cells surrounding the necrotic core, surrounded by a more distal halo of ER-positive cells. Conclusions PGRMC1 phosphorylation may be involved in the clinical differences that underpin breast tumors of differing ER status.
NKp80 defines and stimulates a reactive subset of CD8 T cells
2008-10-15

Abstract NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release. Recently, we demonstrated that the ligand for NKp80 is the myeloid-specific CTLR activation-induced C-type lectin (AICL), which is encoded in the natural killer gene complex (NKC) adjacent to NKp80. Here, we show that NKp80 also is expressed on a minor fraction of human CD8 T cells that exhibit a high responsiveness and an effector memory phenotype. Gene expression profiling and flow cytometric analyses revealed that this NKp80+ T-cell subset is characterized by the coexpression of other NK receptors and increased levels of cytotoxic effector molecules and adhesion molecules mediating access to sites of inflammation. NKp80 ligation augmented CD3-stimulated degranulation and interferon (IFN)γ secretion by effector memory T cells. Furthermore, engagement of NKp80 by AICL-expressing transfectants or macrophages markedly enhanced CD8 T-cell responses in alloreactive settings. Collectively, our data demonstrate that NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells. Hence, NKp80 may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation.
Crystal Structures, Phase-Transition, and Photoluminescence of Rare Earth Carbodiimides
2008-10-15

Rare earth carbodiimides with the general formula RE 2(CN 2) 3 crystallize with two modifications. A monoclinic( C2/m) modification is obtained for RE = Y, Ce-Tm and a rhombohedral ( R3 c) modification for RE = Tm-Lu. The space group R3 c is confirmed by single-crystal structure determination on Lu 2(CN 2) 3 and indexed powder patterns of RE = Tm, Yb and Lu. The use of diverse chemical syntheses conditions for Tm 2(CN 2) 3 revealed the dimorphic character of this compound. In addition, pressure experiments on Tm 2(CN 2) 3 have induced a phase-transition from rhombohedral to monoclinic. This transformation comprises an increase of the coordination number of Tm from 6 to 7, and a unit-cell volume reduction in the order of 20 %. The photoluminescence behavior of lanthanide doped Gd 2(CN 2) 3:Ln samples is presented with different activators (Ln = Ce, Tb) revealing a broad band emission of Gd 2(CN 2) 3:Ce, quite similar to that of the well-known YAG:Ce.
Cystectomy in women
2008-10-15

The technique for radical cystectomy in women is described, with special consideration given to the pelvic anatomy, and the urethra‐ and nerve‐sparing approach in female patients. Advances in understanding female pelvic anatomy, following detailed animal, cadaveric and clinical studies, merged to give a better intraoperative identification of the sphincteric apparatus and neurovascular structures. Respecting the oncological premises, cystectomy in female patients can be done with a nerve‐sparing technique. In rare cases the entire inner genitalia, including the anterior vaginal wall, can be preserved, which might lead to improved functional results with greater patient satisfaction. However, the oncological result should never be endangered by organ preservation.
Ultraviolet and Visible Spectroscopy
2008-10-15

Abstract The article contains sections titled: 1. Introduction 1.1. Comparison with Other Spectroscopic Methods 1.2. Development and Uses 2. Theoretical Principles 2.1. Electronic States and Orbitals 2.2. Interaction Between Radiation and Matter 2.2.1. Dispersion 2.2.2. Absorption 2.2.3. Scattering 2.2.4. Reflection 2.2.5. Band Intensity 2.3. The Lambert–BeerLaw 2.3.1. Definitions 2.3.2. Deviations from the Lambert ‐ Beer Law 2.4. Photophysics 2.4.1. Energy Level Diagram 2.4.2. Deactivation Processes 2.4.3. Transition Probability and Fine Structure of the Bands 2.5. Chromophores 2.6. Optical Rotatory Dispersion and Circular Dichroism 2.6.1. Generation of Polarized Radiation 2.6.2. Interaction with Polarized Radiation 2.6.3. Optical Rotatory Dispersion 2.6.4. Circular Dichroism and the Cotton Effect 2.6.5. Magnetooptical Effects 3. Optical Components and Spectrometers 3.1. Principles of Spectrometer Construction 3.1.1. Sequential Measurement of Absorption 3.1.2. Multiplex Methods in Absorption Spectroscopy 3.2. Light Sources 3.2.1. Line Sources 3.2.2. Sources of Continuous Radiation 3.2.3. Lasers 3.3. Selection of Wavelengths 3.3.1. Prism Monochromators 3.3.2. Grating Monochromators 3.3.3. Electro‐Acoustic and Opto‐Acoustic Wavelength Generation 3.4. Polarizers and Analyzers 3.5. Sample Compartments and Cells 3.5.1. Closed Compartments 3.5.2. Modular Arrangements 3.5.3. Open Compartments 3.6. Detectors 3.7. Optical Paths for Special Measuring Requirements 3.7.1. Fluorescence Measurement 3.7.2. Measuring Equipment for Polarimetry, ORD, and CD 3.7.3. Reflection Measurement 3.7.4. Ellipsometry 3.8. Effect of Equipment Parameters 3.9. Connection to Electronic Systems and Computers 4. Uses of UV ‐ VIS Spectroscopy in Absorption, Fluorescence, and Reflection 4.1. Identification of Substances and Determination of Structures 4.2. Quantitative Analysis 4.2.1. Determination of Concentration by Calibration Curves 4.2.2. Classical Multicomponent Analysis 4.2.3. <jats:sty
English focus inversion
2008-10-16

Besides the canonical Subject–I–VP structure, English has several inversion constructions in which the subject follows the inflected verb. The most familiar is Subject Auxiliary Inversion (SAI) which is analyzed as an instance of Head Movement (I–to–C-movement across the subject) in the generative tradition. In this paper we investigate Comparative Inversion (CI), which appears to be a special case of SAI in which ellipsis is required (Merchant 2003). Contrary to this analysis, we show that the subject can stay low in a noncanonical position, violating the Extended Projection Principle (EPP) in exactly those instances where it is under comparison and therefore heavily accented and contrastively focused. Our analysis shows that the non-application of the EPP is tied to regular interactions of syntax with phonology and syntax with semantics. We extend this in depth analysis to other English focus inversions and provide evidence that phonological highlighting and focus on the low subject can suspend the EPP. Thus, our analysis supports research programs which assume minimal syntactic structure and operations in interaction with interface constraints that are independently required for explanation.
A Novel CD19-directed Recombinant Bispecific Antibody Derivative With Enhanced Immune Effector Functions for Human Leukemic Cells
2008-10-16

A novel bispecific antibody-derived recombinant protein targeting leukemias and lymphomas was designed, a single-chain Fv triple body (sctb) consisting of 1 polypeptide chain with 3 scFvs connected in tandem. The distal scFvs were specific for the tumor antigen CD19, and the central scFv for the trigger molecule CD16 (FcgammaRIII) on natural killer (NK) cells and macrophages. We had previously built a disulphide stabilized (ds) bsscFv [19 x 16] with monovalent binding for CD19 from ds components. The sctb ds[19 x 16 x 19] also used ds components and displayed 3-fold greater avidity for CD19 than the bsscFv (KD = 13 vs. 42 nM), whereas both had equal affinity for CD16 (KD = 58 nM). Plasma half-lives in mice were 4 and 2 hours for the sctb and the bsscFv, respectively. In antibody-dependent cellular cytotoxicity reactions with human mononuclear cells as effectors, the sctb promoted equal lysis of leukemic cell lines and primary cells from leukemia and lymphoma patients at 10-fold to 40-fold lower concentrations than the bsscFv. This new format may also be applicable to a variety of other tumor antigens and effector molecules. With half-maximum effective concentrations (EC50) in the low picomolar range, the sctb ds[19 x 16 x 19] is an attractive candidate for further preclinical evaluation.