303 IMPACT OF ALTERED WNT1/β-CATENIN EXPRESSION ON CLINICOPATHOLOGY AND PROGNOSIS IN RENAL CELL CARCINOMA
2013-03-27

You have accessJournal of UrologyKidney Cancer: Basic Research (II)1 Apr 2013303 IMPACT OF ALTERED WNT1/β-CATENIN EXPRESSION ON CLINICOPATHOLOGY AND PROGNOSIS IN RENAL CELL CARCINOMA Stephan Kruck, Christian Eyrich, Marcus Scharpf, Hossein Tezval, Karl-Dietrich Sievert, Axel Merseburger, Arnulf Stenzl, and Jens Bedke Stephan KruckStephan Kruck Tuebingen, Germany More articles by this author , Christian EyrichChristian Eyrich Tuebingen, Germany More articles by this author , Marcus ScharpfMarcus Scharpf Tuebingen, Germany More articles by this author , Hossein TezvalHossein Tezval Hannover, Germany More articles by this author , Karl-Dietrich SievertKarl-Dietrich Sievert Tuebingen, Germany More articles by this author , Axel MerseburgerAxel Merseburger Hannover, Germany More articles by this author , Arnulf StenzlArnulf Stenzl Tuebingen, Germany More articles by this author , and Jens BedkeJens Bedke Tuebingen, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1687AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Members of the Wnt/β-catenin signaling pathway are abnormally expressed in renal cell carcinoma (RCC). This study analyzed the role of Wnt1/β-catenin alterations in clear cell RCC (ccRCC) with regard to clinicopathology, overall survival (OS) and cancer specific survival (CSS) to prove the options of a Wnt targeted therapy. METHODS Corresponding ccRCCs and benign renal tissue were analyzed in 278 patients for Wnt1 and β-catenin by immunohistochemistry in tissue microarrays. Expression scores including intensity and percentage of stained cells were compared between normal kidney and ccRCCs. Data was categorized according to the mean expressions core and correlated to tumor and patientsÆ characteristics and analyzed for OS and CSS according to the Kaplan-Meier and log-rank test. To identify prognostics value of wnt1 and β-catenin, univariable and multivariable Cox proportional hazard regression models were used. RESULTS High Wnt1 tumor expression was associated with increased tumor diameter (p=0.01), stage (p=0.004) and vascular invasion (p=0.02). Positive membranous β-catenin was associated with advanced stage (p=0.003), vascular invasion (p=0.01) and tumor necrosis (p=0.004). Increased tumor diameter (p=0.01), stage (p=0.003), node involvement (0.04), grade (p=0.001), vascular invasion (p=0.002), and sarcomatoid differentiation (p=0.01) were found in patients with high cytoplasmic β-catenin. Furthermore, this patient subgroup showed reduced OS (p=0.03) and CSS (p=0.009). CONCLUSIONS Significant clinicopathological associations underline the oncogenic potential of Wnt1/β-catenin pathway parameters. Whereas, cytoplasmic β-catenin was identified as the most valuable parameter with regard to clinico-prognostic implications for future targeted therapies. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e123 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stephan Kruck Tuebingen, Germany More articles by this author Christian Eyrich Tuebingen, Germany More articles by this author Marcus Scharpf Tuebingen, Germany More articles by this author Hossein Tezval Hannover, Germany More articles by this author Karl-Dietrich Sievert Tuebingen, Germany More articles by this author Axel Merseburger Hannover, Germany More articles by this author Arnulf Stenzl Tuebingen, Germany More articles by this author Jens Bedke Tuebingen, Germany More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...