julilili42/papers huggingface dataset:
The formation of systems with closely spaced low-mass planets and the application to Kepler-36
2013-07-30

The Kepler-36 system consists of two planets that are spaced unusually close together, near the 7:6 mean motion resonance. While it is known that mean motion resonances can easily form by convergent migration, Kepler-36 is an extreme case due to the close spacing and the relatively high planet masses of 4 and 8 times that of the Earth. In this paper, we investigate whether such a system can be obtained by interactions with the protoplanetary disc. These discs are thought to be turbulent and exhibit density fluctuations which might originate from the magneto-rotational instability. We adopt a realistic description for stochastic forces due to these density fluctuations and perform both long term hydrodynamical and N-body simulations. Our results show that planets in the Kepler-36 mass range can be naturally assembled into a closely spaced planetary system for a wide range of migration parameters in a turbulent disc similar to the minimum mass solar nebula. The final orbits of our formation scenarios tend to be Lagrange stable, even though large parts of the parameter space are chaotic and unstable.
Multicolor Microscopy and Spectroscopy Reveals the Physics of the One-Photon Luminescence in Gold Nanorods
2013-07-30

This work demonstrates for the first time that one-photon luminescence in gold nanorods is an entirely plasmon-induced process. To achieve this goal, we used confocal microscopy in combination with higher order laser modes as well as light spectroscopy. We show that gold nanorod luminescence can be produced in three different ways: first, by directly exciting their longitudinal and transversal plasmon modes; second, by an energy transfer from the transversal to the longitudinal plasmon mode promoted by electron–holes pairs; and third, by conversion of directly excited electron holes pairs into the longitudinal plasmon mode.
Physical Predictors of Cognitive Performance in Healthy Older Adults: A Cross-Sectional Analysis
2013-07-30

There is ample evidence that physical and cognitive performance are related, but the results of studies investigating this relationship show great variability. Both physical performance and cognitive performance are constructs consisting of several subdomains, but it is presently unknown if the relationship between physical and cognitive performance depends on subdomain of either construct and whether gender and age moderate this relationship. The aim of this study is to identify the strongest physical predictors of cognitive performance, to determine the specificity of these predictors for various cognitive subdomains, and to examine gender and age as potential moderators of the relationship between physical and cognitive performance in a sample of community-dwelling older adults. In total, 98 men and 122 women (average age 74.0±5.6 years) were subjected to a series of performance-based physical fitness and neuropsychological tests. Muscle strength, balance, functional reach, and walking ability (combined score of walking speed and endurance) were considered to predict cognitive performance across several domains (i.e. memory, verbal attention, visual attention, set-shifting, visuo-motor attention, inhibition and intelligence). Results showed that muscle strength was a significant predictor of cognitive performance for men and women. Walking ability and balance were significant predictors of cognitive performance for men, whereas only walking ability was significant for women. We did not find a moderating effect of age, nor did we find support for a differential effect of the physical predictors across different cognitive subdomains. In summary, our results showed a significant relationship between cognitive and physical performance, with a moderating effect of gender.
A convergent finite-element-based discretization of the stochastic Landau-Lifshitz-Gilbert equation
2013-07-30

We propose a convergent finite-element-based discretization of the stochastic Landau–Lifshitz–Gilbert equation. The main difficulties in the convergence analysis for this nonlinear stochastic partial differential equation are to properly address the pointwise sphere condition and, in the fully discrete scheme, the Stratonovich noise. Approximations of the scheme proposed here satisfy a sphere constraint at nodal points of the spatial discretization and have finite energies, and their increments may be controlled uniformly with respect to discretization parameters. Sequences of corresponding continuified processes may then be generated which construct weak martingale solutions of the limiting equations.
SUPERCONDUCTIVITY OF MAGNESIUM DIBORIDE: THEORETICAL ASPECTS
2013-07-30

Our theoretical understanding of superconductivity in magnesium diboride (MgB2) has made rapid progress since its discovery by Nagamatsu et al. [1]. Unlike superconductivity in the high-Tc cuprates we are in a possession of a very clear picture of its superconducting state now [2]. It seems clear that superconductivity is driven by electron-phonon interaction in
CHU'S CONFIRMATION OF EINSTEIN'S EQUIVALENCE PRINCIPLE, C-GLOBAL, AND THE WIDELY IGNORED FACTOR 30 000
2013-07-30

A brief historical account of the paradox of the gravitational clock slowdown is offered. It took Einstein’s finding more than a century to have its main consequence fully appreciated in the wake of the quantum-relativistic results of the Chu school. A return to the global constancy of the speed of light c is implicit. The latter finding enables an improved understanding of the theory of black holes and in particular of a recent mega experiment which proves unsafe in the new light. Neglect of a factor of 30 000 by the scientific community is drawn attention to.
Pathogen-Host Associations and Predicted Range Shifts of Human Monkeypox in Response to Climate Change in Central Africa
2013-07-31

Climate change is predicted to result in changes in the geographic ranges and local prevalence of infectious diseases, either through direct effects on the pathogen, or indirectly through range shifts in vector and reservoir species. To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in humans, under contemporary and future climate conditions, we used ecological niche modeling techniques in conjunction with climate and remote-sensing variables. We first created spatially explicit probability distributions of its candidate reservoir species in Africa's Congo Basin. Reservoir species distributions were subsequently used to model current and projected future distributions of human monkeypox (MPX). Results indicate that forest clearing and climate are significant driving factors of the transmission of MPX from wildlife to humans under current climate conditions. Models under contemporary climate conditions performed well, as indicated by high values for the area under the receiver operator curve (AUC), and tests on spatially randomly and non-randomly omitted test data. Future projections were made on IPCC 4(th) Assessment climate change scenarios for 2050 and 2080, ranging from more conservative to more aggressive, and representing the potential variation within which range shifts can be expected to occur. Future projections showed range shifts into regions where MPX has not been recorded previously. Increased suitability for MPX was predicted in eastern Democratic Republic of Congo. Models developed here are useful for identifying areas where environmental conditions may become more suitable for human MPX; targeting candidate reservoir species for future screening efforts; and prioritizing regions for future MPX surveillance efforts.
Phase Retrapping in a PointlikeφJosephson Junction: The Butterfly Effect
2013-07-31

We consider a φ Josephson junction, which has a bistable zero-voltage state with the stationary phases ψ = ±φ. In the nonzero voltage state the phase "moves" viscously along a tilted periodic double-well potential. When the tilting is reduced quasistatically, the phase is retrapped in one of the potential wells. We study the viscous phase dynamics to determine in which well (-φ or +φ) the phase is retrapped for a given damping, when the junction returns from the finite-voltage state back to the zero-voltage state. In the limit of low damping, the φ Josephson junction exhibits a butterfly effect-extreme sensitivity of the destination well on damping. This leads to an impossibility to predict the destination well.
IMA901: a peptide vaccine in renal cell carcinoma
2013-07-31

IMA901 is a first-in-class drug, which is administered together with GM-CSF and single-dose cyclophosphamide. This triumvirate of vaccine, a local and a systemic immunomodulator showed an improved clinical benefit in mRCC patients. This interplay effectively activated cytotoxic T cells. Future strategies will lead to improved local immunomodulators to boost the activation of APCs, systemic immunomodulators to suppress Tregs and myeloid-derived suppressor cells (MDSCs) and antigens of higher cancer specificity and immunogenicity, together with an optimal schedule and dosage of the vaccine.
Attention deficit hyperactivity disorder (ADHD): An affect‐processing and thought disorder?
2013-07-31

In the literature on child and adolescent psychoanalysis attention deficit hyperactivity disorder (ADHD) is described as complex syndrome with wide-ranging psychodynamic features. Broadly speaking, the disorder is divided into three categories: 1. a disorder in early object relations leading to the development of a maniform defence organization in which object-loss anxieties and depressed affects are not worked through via symbolization but are organized in a body-near manner; 2. a triangulation disorder in which the cathexis of the paternal position is not stable; structures providing little support alternate with excessive arousal, affect regulation is restricted; 3. current emotional stress or a traumatic experience. I suggest taking a fresh look at ADHD from a psychoanalytic vantage point. With respect to the phenomenology of the disorder, the conflict-dynamic approach should be supplemented by a perspective regarding deficits in α-function as constitutive for ADHD. These deficits cause affect-processing and thought disorders compensated for (though not fully) by the symptomatology. At a secondary level, a vicious circle develops through the mutual reinforcement of defective processing of sense data and affects into potential thought content, on the one hand, and secondary, largely narcissistic defence processes on the other. These considerations have major relevance for the improved understanding of ADHD and for psychoanalytic technique.
Density of k-Box-Products and the existence of generalized independent families
2013-07-31

[EN] In this paper we will prove a slight generalisation of the Hewitt-Marczewski-Pondiczery theorem concerning the density of k-box-products. With this result we will prove the existence of generalized independent families of big cardinality which were introduced by Wanjun Hu.
Faculty Opinions recommendation of Nivolumab plus ipilimumab in advanced melanoma.
2013-07-31

BACKGROUND: In patients with melanoma, ipilimumab (an antibody against cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4]) prolongs overall survival, and nivolumab (an antibody against the programmed death 1 [PD-1] receptor) produced durable tumor regression in a phase 1 trial. On the basis of their distinct immunologic mechanisms of action and supportive preclinical data, we conducted a phase 1 trial of nivolumab combined with ipilimumab in patients with advanced melanoma.METHODS: We administered intravenous doses of nivolumab and ipilimumab in patients every 3 weeks for 4 doses, followed by nivolumab alone every 3 weeks for 4 doses (concurrent regimen). The combined treatment was subsequently administered every 12 weeks for up to 8 doses. In a sequenced regimen, patients previously treated with ipilimumab received nivolumab every 2 weeks for up to 48 doses.RESULTS: A total of 53 patients received concurrent therapy with nivolumab and ipilimumab, and 33 received sequenced treatment. The objective-response rate (according to modified World Health Organization criteria) for all patients in the concurrent-regimen group was 40%. Evidence of clinical activity (conventional, unconfirmed, or immune-related response or stable disease for ≥24 weeks) was observed in 65% of patients. At the maximum doses that were associated with an acceptable level of adverse events (nivolumab at a dose of 1 mg per kilogram of body weight and ipilimumab at a dose of 3 mg per kilogram), 53% of patients had an objective response, all with tumor reduction of 80% or more. Grade 3 or 4 adverse events related to therapy occurred in 53% of patients in the concurrent-regimen group but were qualitatively similar to previous experience with monotherapy and were generally reversible. Among patients in the sequenced-regimen group, 18% had grade 3 or 4 adverse events related to therapy and the objective-response rate was 20%.CONCLUSIONS: Concurrent therapy with nivolumab and ipilimumab had a manageable safety profile and provided clinical activity that appears to be distinct from that in published data on monotherapy, with rapid and deep tumor regression in a substantial proportion of patients. (Funded by Bristol-Myers Squibb and Ono Pharmaceutical; ClinicalTrials.gov number, NCT01024231.). PMID: 23724867 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: P30 CA008748 NCI NIH HHS, United States Grant ID: K24 CA172123
Adaptor Protein Complex 2–Mediated Endocytosis Is Crucial for Male Reproductive Organ Development in Arabidopsis
2013-08-01

Fertilization in flowering plants requires the temporal and spatial coordination of many developmental processes, including pollen production, anther dehiscence, ovule production, and pollen tube elongation. However, it remains elusive as to how this coordination occurs during reproduction. Here, we present evidence that endocytosis, involving heterotetrameric adaptor protein complex 2 (AP-2), plays a crucial role in fertilization. An Arabidopsis thaliana mutant ap2m displays multiple defects in pollen production and viability, as well as elongation of staminal filaments and pollen tubes, all of which are pivotal processes needed for fertilization. Of these abnormalities, the defects in elongation of staminal filaments and pollen tubes were partially rescued by exogenous auxin. Moreover, DR5rev:GFP (for green fluorescent protein) expression was greatly reduced in filaments and anthers in ap2m mutant plants. At the cellular level, ap2m mutants displayed defects in both endocytosis of N-(3-triethylammonium-propyl)-4-(4-diethylaminophenylhexatrienyl) pyridinium dibromide, a lypophilic dye used as an endocytosis marker, and polar localization of auxin-efflux carrier PIN FORMED2 (PIN2) in the stamen filaments. Moreover, these defects were phenocopied by treatment with Tyrphostin A23, an inhibitor of endocytosis. Based on these results, we propose that AP-2-dependent endocytosis plays a crucial role in coordinating the multiple developmental aspects of male reproductive organs by modulating cellular auxin level through the regulation of the amount and polarity of PINs.
Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation
2013-08-01

Abstract Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior. Hum Brain Mapp 35:1944–1956, 2014 . © 2013 Wiley Periodicals, Inc.
Nitrogen isotopic composition of collagen amino acids as an indicator of aquatic resource consumption: insights from Mesolithic and Epipalaeolithic archaeological sites in France
2013-08-01

Abstract Aquatic resource exploitations in human evolution have raised many questions related to cognitive abilities and subsistence developments. It has been pointed out that the evaluation of freshwater resource consumption based on conventional stable CN isotopic composition of bulk bone collagen faces some difficulties, primarily because isotopic distinction between terrestrial and freshwater animals can be ambiguous and, even worse, can show similar values. In this study we tested the potential of nitrogen isotope analysis of individual amino acids in this evaluation. Our preliminary results for archaeological human and faunal remains from Mesolithic and Epipalaeolithic sites in France (Noyen-sur-Seine and Pont d'Ambon) show that estimated trophic positions for terrestrial animals based on δ15N of glutamic acid and phenylalanine are more precise than the bulk collagen isotopic method, allowing human aquatic resource consumptions to be identified. However, since the ability to quantify is still limited, a combination of several approaches is recommended.
Controlling the Texture and Crystallinity of Evaporated Lead Phthalocyanine Thin Films for Near-Infrared Sensitive Solar Cells
2013-08-01

To achieve organic solar cells with a broadened spectral absorption, we aim to promote the growth of the near-infrared (NIR)-active polymorph of lead phthalocyanine (PbPc) on a relevant electrode for solar cell applications. We studied the effect of different substrate modification layers on PbPc thin film structure as a function of thickness and deposition rate (rdep). We characterized crystallinity and orientation by grazing incidence X-ray diffraction (GIXD) and in situ X-ray reflectivity (XRR) and correlated these data to the performance of bilayer solar cells. When deposited onto a self-assembled monolayer (SAM) or a molybdenum oxide (MoO3) buffer layer, the crystallinity of the PbPc films improves with thickness. The transition from a partially crystalline layer close to the substrate to a more crystalline film with a higher content of the NIR-active phase is enhanced at low rdep, thereby leading to solar cells that exhibit a higher maximum in short circuit current density (JSC) for thinner donor layers. The insertion of a CuI layer induces the formation of strongly textured, crystalline PbPc layers with a vertically homogeneous structure. Solar cells based on these templated donor layers show a variation of JSC with thickness that is independent of rdep. Consequently, without decreasing rdep we could achieve JSC=10 mA/cm2, yielding a bilayer solar cell with a peak external quantum efficiency (EQE) of 35% at 900 nm, and an overall power conversion efficiency (PCE) of 2.9%.
Rome III criteria in parents’ hands
2013-08-01

Rome III abdominal pain-related functional gastrointestinal disorders are a common health problem in children and are, even in community, strongly associated with other somatic complaints and psychological distress.
HESS and Fermi-LAT discovery of γ-rays from the blazar 1ES 1312−423
2013-08-01

A deep observation campaign carried out by the High Energy Stereoscopic System (HESS) on Centaurus A enabled the discovery of γ-rays from the blazar 1ES 1312−423, 2° away from the radio galaxy. With a differential flux at 1 TeV of φ(1 TeV) = (1.9 ± 0.6stat ± 0.4sys) × 10−13 cm−2 s−1 TeV−1 corresponding to 0.5 per cent of the Crab nebula differential flux and a spectral index Γ = 2.9 ± 0.5stat ± 0.2sys, 1ES 1312−423 is one of the faintest sources ever detected in the very high energy (E &gt; 100 GeV) extragalactic sky. A careful analysis using three and a half years of Fermi Large Area Telescope (Fermi-LAT) data allows the discovery at high energies (E &gt; 100 MeV) of a hard spectrum (Γ = 1.4 ± 0.4stat ± 0.2sys) source coincident with 1ES 1312−423. Radio, optical, UV and X-ray observations complete the spectral energy distribution of this blazar, now covering 16 decades in energy. The emission is successfully fitted with a synchrotron self-Compton model for the non-thermal component, combined with a blackbody spectrum for the optical emission from the host galaxy
On The Applicability of Readability Models to Web Texts
2013-08-01

An increasing range of features is being used for automatic readability classification. The impact of the features typically is evaluated using reference corpora containing graded reading material. But how do the readability models and the features they are based on perform on real-world web texts? In this paper, we want to take a step towards understanding this aspect on the basis of a broad range of lexical and syntactic features and several web datasets we collected. Applying our models to web search results, we find that the average reading level of the retrieved web documents is relatively high. At the same time, documents at a wide range of reading levels are identified and even among the Top-10 search results one finds documents at the lower levels, supporting the potential usefulness of readability ranking for the web. Finally, we report on generalization experiments showing that the features we used generalize well across different web sources. 1
Correlation between Cerebral Blood Volume Measurements by Perfusion-Weighted Magnetic Resonance Imaging and Two-Year Progression-Free Survival in Gliomas
2013-08-01

Our goal was to determine whether relative cerebral blood volume (rCBV) can serve as an adjunct to histopathologic grading in the assessment of gliomas, with the hypothesis that rCBV can predict two-year survival. We evaluated 29 newly diagnosed gliomas (13 WHO grade II, seven grade III, nine grade TV; 17 astrocytomas, 12 oligodendroglial tumors). Dynamic susceptibility-weighted contrast-enhanced perfusion MR images and CBV maps were obtained. rCBVmax measurements (maximum tumor CBV/contralateral normal tissue CBV) and progression-free survival (PFS) were recorded. Receiver operating characteristic curves and Kaplan-Meier survival curves were calculated for rCBVmax and histologic grade. rCBVmax measurements differed between gliomas without (2.38 +/− 1.22) and with progression (5.57 +/− 2.84) over two years. The optimal rCBVmax cut-off value to predict progression was 2.95. rCBVmax &lt; 2.95 was a significant predictor of two-year PFS, almost as accurate as WHO grade IT In the pure astrocytoma subgroup, the optimal rCBVmax cut-off value to predict progression was 2.85. In this group rCBVmax &lt; 2.85 was a significant predictor of two-year PFS, an even better predictor of two-year PFS than WHO grade IT rCBVmax can be used to predict two-year PFS in patients with gliomas, independent of pathologic findings, especially in tumors without oligodendroglial components.
HDAC inhibitors and their potential applications to glioblastoma therapy
2013-08-01

Natural killer (NK) cells are integral components of the antitumor immune response. The downregulation of ligands for NK-cell stimulatory receptors represents a strategy whereby glioblastoma cells can evade NK-cell attacks. Histone deacetylase inhibitors can stimulate the (re)expression of these ligands, driving cytotoxic responses against glioblastoma cells that efficiently inhibit tumor growth.