julilili42/papers huggingface dataset:
Die Kantate als musikoliterarische Gattung.
2023-09-18

Abstract The cantata genre is one of the most important intermedial art forms in European cultural history. Originating in Italy, it has also been used productively in music and literature in Germany since the late 17th and early 18th centuries. Since Erdmann Neumeister, who was the first to formulate a poetics of the (madrigal) cantata, numerous cantata poems have been written, which – even before they are potentially set to music – are literary artifacts in their own right. It is therefore surprising that the genre of the cantata has been researched almost exclusively by musicologists, and that there has been a lack of literary studies, and consequently, interdisciplinary approaches, which would be necessary for a systematic understanding of the cantata as a musical-literary hybrid genre. This article is intended as a contribution to an interdisciplinary study of the cantata. It examines the cantata text “Ich will den Kreuzweg gerne gehen”, written by Erdmann Neumeister and set to music by Georg Philipp Telemann, according to literary-textual and musical criteria, paying particular attention to the mechanisms and dynamics of the interaction between text and music.
Das Lied in der Frühen Neuzeit.
2023-09-18

Abstract This article outlines the status, tasks, and desiderata of research on the song of the early modern period. The starting point of the contribution is Adorno’s rejection of the Lied from an ideology-critical and autonomy-aesthetic point of view. In the post-war period, this had consequences for research on the Lied as well as for the social treatment of this form. On the other hand, national-philological perspectives continued to dominate for a long time; at the same time, the song ( Lied ) was not only neglected in research, but also the singing of songs became suspect and was increasingly rejected in music didactics. Only new discussions, first about terminology ( Musikalische Lyrik , Danuser 2004), have made the song attractive again. Recent research has focused on aspects such as translation, mobility, social history, and praxeology. Using examples of early modern song authors like Heinrich Müller, Heinrich Albert, Martin Opitz, and especially Johann Rist, this essay presents these new perspectives.
Spracharbeit und interkonfessionelle Liedtradition
2023-09-18

Abstract This article deals with the numerous psalm songs that Martin Opitz composed between 1626 and 1638 to melodies from the Geneva Psalter. It discusses them in the context of the great tradition of Protestant psalm songs which had flourished since the Reformation and considers their role for Opitz’s poetics and linguistic reflection (‘Spracharbeit’). In the first part, the essay presents Opitz’s translation work on the Psalter showing that the poet wanted to create a normative example of German-language sacred poetry. We then reconstruct Opitz’s poetics on the basis of his songs on Psalm 6, linking it to the European tradition of the psalm song as well as to theological and dogmatic issues.
An inclusive typology of values for navigating transformations towards a just and sustainable future
2023-09-19

Achieving the intertwined goals of justice and sustainability requires transformative changes to meaningfully engage diverse perspectives. Therefore, scholars and policymakers need new ways of recognising and addressing nature's multiple values across cultures, disciplines and other knowledge traditions. By reviewing academic publications, policy documents and Indigenous and local community sources, we developed an inclusive typology of nature's values to clarify value concepts and guide their consideration in decisions. Through case studies, we illustrate how navigating ‘horizontal’ and ‘vertical’ interactions within and across this typology can help confront plural-value challenges, such as enhancing inclusive participation in environmental research and practice, and effective management of socio-environmental conflicts. We conclude by exploring how this typology of values can further leverage transformative change in other decision-making contexts. © 2023 The Author(s)
Justice, sustainability, and the diverse values of nature: why they matter for biodiversity conservation
2023-09-19

Aiming at just and sustainable futures for biodiversity conservation requires clarity concerning how justice relates to the diverse values of nature. By drawing upon and expanding on the recent Values Assessment of Intergovernmental Platform on Biodiversity and Ecosystem Services, this article discusses the implications of the diverse values of nature for different dimensions of justice. It also addresses how achieving transformative change that protects biodiversity requires the inclusion of diverse values of nature into valuation and decision-making processes, and how this imperative is interconnected with different dimensions of justice.
Teacher perceptions of student motivation and engagement: longitudinal associations with student outcomes
2023-09-19

Abstract Studies have shown that teacher perceptions of student achievement influence teacher-student interactions, subsequently affecting student outcomes. However, teachers may also take note of and respond to the motivation and engagement of their students in a differential way, which could affect student outcomes as well. In the present study, we thus examined whether teacher perceptions of student motivation and engagement predict student achievement and self-reported motivation and engagement in reading and maths over several school years. Analysing longitudinal data from N = 2402 students and their teachers, we found that teacher perceptions of student motivation and engagement in Grade 5 were significantly related to student achievement in reading 1 year later and in maths 1, 2, and 3 years later. An association with student motivation and engagement was only found for maths 1 year later.
Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
2023-09-19

Staphylococcus aureus is the most common cause of bacterial skin infections in humans, including patients with atopic dermatitis (AD). Polymorphonuclear neutrophils (PMNs) are the first cells to infiltrate an infection site, where they usually provide an effective first line of defense, including neutrophil extracellular trap (NET) formation. Here, we show that infiltrating PMNs in inflamed human and mouse skin enhance S. aureus skin colonization and persistence. Mechanistically, we demonstrate that a crosstalk between keratinocytes and PMNs results in enhanced NET formation upon S. aureus infection, which in turn induces oxidative stress and expression of danger-associated molecular patterns such as high-mobility-group-protein B1 (HMGB1) in keratinocytes. In turn, HMGB1 enhances S. aureus skin colonization and persistence by promoting skin barrier dysfunctions by the downregulation of epidermal barrier genes. Using patient material, we show that patients with AD exhibit enhanced presence of PMNs, NETs, and HMGB1 in the skin, demonstrating the clinical relevance of our finding.
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
2023-09-19

Hepatic in vitro models that accurately replicate phenotypes and functionality of the human liver are needed for applications in toxicology, pharmacology and biomedicine. Notably, it has become clear that liver function can only be sustained in 3D culture systems at physiologically relevant cell densities. Additionally, drug metabolism and drug-induced cellular toxicity often follow distinct spatial micropatterns of the metabolic zones in the liver acinus, calling for models that capture this zonation. We demonstrate the manufacture of accurate liver microphysiological systems (MPS) via engineering of 3D stereolithography printed hydrogel chips with arrays of diffusion open synthetic vasculature channels at spacings approaching in vivo capillary distances. Chip designs are compatible with seeding of cell suspensions or preformed liver cell spheroids. Importantly, primary human hepatocytes (PHH) and hiPSC-derived hepatocyte-like cells remain viable, exhibit improved molecular phenotypes compared to isogenic monolayer and static spheroid cultures and form interconnected tissue structures over the course of multiple weeks in perfused culture. 3D optical oxygen mapping of embedded sensor beads shows that the liver MPS recapitulates oxygen gradients found in the acini, which translates into zone-specific acet-ami-no-phen toxicity patterns. Zonation, here naturally generated by high cell densities and associated oxygen and nutrient utilization along the flow path, is also documented by spatial proteomics showing increased concentration of periportal- versus perivenous-associated proteins at the inlet region and vice versa at the outlet region. The presented microperfused liver MPS provides a promising platform for the mesoscale culture of human liver cells at phenotypically relevant densities and oxygen exposures. STATEMENT OF SIGNIFICANCE: A full 3D tissue culture platform is presented, enabled by massively parallel arrays of high-resolution 3D printed microperfusion hydrogel channels that functionally mimics tissue vasculature. The platform supports long-term culture of liver models with dimensions of several millimeters at physiologically relevant cell densities, which is difficult to achieve with other methods. Human liver models are generated from seeded primary human hepatocytes (PHHs) cultured for two weeks, and from seeded spheroids of hiPSC-derived human liver-like cells cultured for two months. Both model types show improved functionality over state-of-the-art 3D spheroid suspensions cultured in parallel. The platform can generate physiologically relevant oxygen gradients driven by consumption rather than supply, which was validated by visualization of embedded oxygen-sensitive microbeads, which is exploited to demonstrate zonation-specific toxicity in PHH liver models.
Palaeoenvironmental and chronological context of hominin occupations of the Armenian Highlands during MIS 3: Evidence from Ararat-1 cave
2023-09-19

Archaeological and palaeoenvironmental evidence from the Armenian Highlands and wider southern Caucasus region emphasises the significance of Marine Oxygen Isotope Stage 3 (c. 57–29 ka) as a crucial period for understanding hominin behaviours amidst environmental fluctuations. Ararat-1 cave, situated in the Ararat Depression, Republic of Armenia, presents potential for resolving emerging key debates regarding hominin land use adaptations during this interval, due to its well-preserved lithic artefacts and faunal assemblages. We present the first results of combined sedimentological, geochronological (luminescence and radiocarbon), archaeological and palaeoecological (macrofauna, microfauna and microcharcoal) study of the Ararat-1 sequence. We demonstrate sediment accumulation occurred between 52 and 35 ka and was caused by a combination of aeolian activity, cave rockfall and water action. Whilst the upper strata of the Ararat-1 sequence experienced post-depositional disturbance due to faunal and anthropogenic processes, the lower strata remain relatively undisturbed. We suggest that during a stable period within MIS 3, Ararat-1 was inhabited by Middle Palaeolithic hominins amidst a mosaic of semi-arid shrub, grassland, and temperate woodland ecosystems. These hominins utilised local and distant toolstone raw materials, indicating their ability to adapt to diverse ecological and elevation gradients. Through comparison of Ararat-1 with other sequences in the region, we highlight the spatial variability of MIS 3 environments and its on hominin land use adaptations. This demonstrates the importance of the Armenian Highlands for understanding regional MP settlement dynamics during a critical period of hominin dispersals and evolution.
Which Patients With Rhabdomyosarcoma Need Radiotherapy? Analysis of the Radiotherapy Strategies of the CWS-96 and CWS-2002P Studies and SoTiSaR Registry
2023-09-19

PURPOSE To analyze and compare the indications, doses, and application methods of radiotherapy (RT) and their influence on prognosis of patients with localized rhabdomyosarcoma (RMS). METHODS One thousand four hundred seventy patients with localized RMS 21 years and younger entered on CWS-96, CWS-2002P, and SoTiSaR were eligible for the analysis. The median follow-up was 6.5 years (IQR, 3.3-9.5). RESULTS The 5-year event-free survival (EFS) and local control survival (LCS) for 910 (62%) irradiated versus nonirradiated patients were 71% versus 69% and 78% versus 73% ( P = .03), respectively. Ninety-five percent of patients in IRS I (90% embryonal RMS [eRMS]) were nonirradiated (EFS, 87%). Irradiated patients with IRS II had improved LCS (91% v 80%; P = .01) and EFS (not significant). In IRS III, EFS and LCS were significantly better for RT patients: 71% versus 56% ( P = 3.1e-06) and 76% versus 61% ( P = 4.1e-07). Patients with tumors in the head and neck region (orbita, parameningeal, and nonparameningeal) and in other sites had significantly better EFS and LCS and in parameningeal also overall survival (OS). The efficacy of low RT doses of 32 Gy (hyperfractionated, accelerated RT [HART]) and 36 and 41.4 Gy (conventional fractionated RT [CFRT]) in the favorable groups and higher doses of 44.8 Gy (HART) and 50.4 and 55.4 Gy (CFRT) in the unfavorable groups was comparable. Proton RT was used predominantly in head/neck—parameningeal (HN—PM) tumors, with similar EFS and LCS to photon RT. CONCLUSION RT can be omitted in patients with IRS I eRMS. RT improves LCS and EFS in IRS II and III. RT improves OS in patients with HN-PM, with proton RT comparable with photon RT. Doses of 32 Gy (HART) or 36 and 41.4 Gy (CFRT) had comparable efficacy in patients with favorable risk profiles and 44.8 Gy (HART) or 50.4 and 55.8 Gy (CFRT) in the unfavorable groups.
Deinotherium levius and Tetralophodon longirostris (Proboscidea, Mammalia) from the Late Miocene hominid locality Hammerschmiede (Bavaria, Germany), and their biostratigraphic significance for the terrestrial faunas of the European Miocene
2023-09-19

Abstract During the Miocene, proboscideans reached their greatest diversification, and due to their marked evolutionary changes in dental size and morphology, they comprise an important biostratigraphic/biochronological tool. In this article, we study the proboscideans from the Late Miocene hominid locality Hammerschmiede (Germany), whose fossiliferous layers HAM 6, HAM 4 and HAM 5 are dated to 11.42, 11.44 and 11.62 Ma, respectively. The studied material consists of mandibular, tusk and cheek tooth specimens, which are attributed to the deinothere Deinotherium levius and the tetralophodont gomphothere Tetralophodon longirostris . An almost complete juvenile mandible of D. levius was CT-scanned and revealed that the erupting lower tusks represent the permanent ones. The mandible is most possibly associated with a lower deciduous tusk, and therefore these specimens capture the rare, and short in duration, moment of transition between deciduous and permanent lower tusks in fossil proboscideans and represent the first such example in deinotheres. The chronologically well-constrained proboscidean fauna from Hammerschmiede and the examination of other assemblages from European localities indicate that the coexistence of D. levius and T. longirostris characterizes the late Astaracian–earliest Vallesian, while Hammerschmiede may showcase the transition from the Middle Miocene trilophodont ( Gomphotherium )-dominated faunas of central Europe to the Late Miocene tetralophodont-dominated ones. Finally, in order to decipher the dietary preferences of the Hammerschmiede Tetralophodon we performed dental mesowear angle analysis, which revealed a mixed-feeding diet with an important browsing component, significantly different from the heavily browsing one of Deinotherium known from other localities. Such distinct feeding habits between the taxa indicate niche partitioning, which allowed their sympatry.
PENELLOPE
2023-09-19

HM Lup is a young M-type star that accretes material from a circumstellar disk through a magnetosphere. Our aim is to study the inner disk structure of HM Lup and to characterize its variability. We used spectroscopic data from HST/STIS, X-shooter, and ESPRESSO taken in the framework of the ULLYSES and PENELLOPE programs, together with photometric data from TESS and AAVSO. The 2021 TESS light curve shows variability typical for young stellar objects of the “accretion burster” type. The spectra cover the temporal evolution of the main burst in the 2021 TESS light curve. We compared the strength and morphology of emission lines from different species and ionization stages. We determined the mass accretion rate from selected emission lines and from the UV continuum excess emission at different epochs, and we examined its relation to the photometric light curves. The emission lines in the optical spectrum of HM Lup delineate a temperature stratification along the accretion flow. While the wings of the H I and He I lines originate near the star, the lines of species such as Na I , Mg I , Ca I , Ca II , Fe I , and Fe II are formed in an outer and colder region. The shape and periodicity of the 2019 and 2021 TESS light curves, when qualitatively compared to predictions from magnetohydrodynamic models, suggest that HM Lup was in a regime of unstable ordered accretion during the 2021 TESS observation due to an increase in the accretion rate. Although HM Lup is not an extreme accretor, it shows enhanced emission in the metallic species during this high accretion state that is produced by a density enhancement in the outer part of the accretion flow.
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
2023-09-19

Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual motif architecture of these molecules and the variability that can be introduced through differing linker structures and geometries. We report a set of alternatively linked bivalent EGFR inhibitors that simultaneously occupy the ATP substrate and allosteric pockets. Crystal structures show that initial and redesigned linkers bridging a trisubstituted imidazole ATP-site inhibitor and dibenzodiazepinone allosteric-site inhibitor proved successful in spanning these sites. The re-engineered linker yielded a compound that exhibited significantly higher potency (~60 pM) against the drug-resistant EGFR L858R/T790M and L858R/T790M/C797S, which was superadditive as compared with the parent molecules. The enhanced potency is attributed to factors stemming from the linker connection to the allosteric-site group and informs strategies to engineer linkers in bivalent agent design.
Yeast mitochondria can process de novo designed β‐barrel proteins
2023-09-19

Mitochondrial outer membrane β‐barrel proteins are encoded in the nucleus, translated in the cytosol and then targeted to and imported into the respective organelles. Detailed studies have uncovered the mechanisms involved in the import of these proteins and identified the targeting signals and the cytosolic factors that govern their proper biogenesis. Recently, de novo designed eight‐stranded β‐barrel proteins (Tmb2.3 and Tmb2.17) were shown to fold and assemble into lipid membranes. To better understand the general aspects of the biogenesis of β‐barrel proteins, we investigated the fate of these artificial proteins upon their expression in yeast cells. We demonstrate that although these proteins are de novo designed and are not related to bona fide mitochondrial β‐barrel proteins, they were targeted to mitochondria and integrated into the organelle outer membrane. We further studied whether this integration requires components of the yeast mitochondrial import machinery like Tom20, Tom70, Tob55/Sam50 and Mas37/Sam37. Whereas it seems that none of the import receptors was required for the biogenesis of the artificial β‐barrel proteins, we observed a strong dependency on the TOB/SAM complex. Collectively, our findings demonstrate that the mitochondrial outer membrane is the preferential location in yeast cells for any membrane‐embedded β‐barrel protein.
NeighborNet: improved algorithms and implementation
2023-09-20

NeighborNet constructs phylogenetic networks to visualize distance data. It is a popular method used in a wide range of applications. While several studies have investigated its mathematical features, here we focus on computational aspects. The algorithm operates in three steps. We present a new simplified formulation of the first step, which aims at computing a circular ordering. We provide the first technical description of the second step, the estimation of split weights. We review the third step by constructing and drawing the network. Finally, we discuss how the networks might best be interpreted, review related approaches, and present some open questions.
Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review
2023-09-20

Abstract Total hip arthroplasty (THA) is a successful orthopaedic surgical procedure, and its longevity depends on bearing components and implant fixation. Optimizing polyethylene and ceramics has led to improved wear parameters and contributed to improved long-term outcomes. The present systematic review investigated whether time span from implantation, patient characteristics and performance status exert an influence on liner wear and head migration in THA. This study was conducted in conformity to the 2020 PRISMA guidelines. All the clinical investigations which reported quantitative data on the amount of liner wear and head migration in THA were considered. Only studies which reported quantitative data at least on one of the following patient characteristics were suitable: mean age, mean BMI (kg/m 2 ), sex, side, time span between the index THA and the last follow-up (months) were eligible. A multiple linear model regression analysis was employed to verify the association between patient characteristics and the amount of liner wear and/or head migration. The Pearson Product-Moment Correlation Coefficient was used to assess the association between variables. Data from 12,629 patients were considered. The mean length of the follow-up was 90.5 ± 50.9 months. The mean age of patients at surgery was 58.4 ± 9.4 years, and the mean BMI was 27.2 ± 2.5 kg/m 2 . 57% (7199 of 12,629 patients) were women, and in 44% (5557 of 12,629 patients) THAs were performed on the left. The mean pre-operative Harris hip score was 46.5 ± 6.0 points. There was evidence of a moderate positive association between the amount of liner wear and the time elapsed between the index surgery to the follow-up (P = 0.02). There was evidence of a moderate positive association between the amount of head migration and the time elapsed between the index surgery to the follow-up (P = 0.01). No further statistically significant association was found. The time elapsed between the index surgery to the follow-up was the most important factor which influence the head migration and liner wear in THA. Patients’ characteristics and preoperative physical activity did not influence the amount of head migration and liner wear.