julilili42/papers huggingface dataset:
Knowledge Formation in Systemic Counselling Trainees from Germany: A Pilot Study from a Competence-Based Perspective
2021-06-28

Abstract This pilot study has two areas of focus. It examines how the knowledge and competences of twelve Master’s-level systemic counselling trainees are connected, and how well their own assessment of their competence corresponds to external assessment. Methodologically, three instruments were used: first, an instrument to measure their explicit knowledge; second, videos of consultations with simulated clients to measure their competence in practice; third, a self-assessment measure to explore how externally assessed competence corresponds to self-assessment. The results show no indication that knowledge is related to externally assessed competence. Furthermore, their self-assessment did not show any systematic connection to the external assessment. The study concludes that the development of systemic counselling skills is a long-term process of theory acquisition, practise, and reflection. Important reflection processes can be stimulated by self-assessment. However, such assessments are not sufficient to capture the quality and scope of competence.
A first eROSITA view of ultracool dwarfs
2021-06-28

We present the first X-ray detections of ultracool dwarfs (UCDs) from the first all-sky survey of the extended ROentgen Survey with an Imaging Telescope Array (eROSITA) onboard the Russian Spektrum-Roentgen-Gamma mission. We use three publicly available input catalogs of spectroscopically confirmed UCDs and Gaia -selected UCD candidates that together comprise nearly 20000 objects. In a careful source identification procedure we first extracted all X-ray sources from the catalog of the first survey, eRASS1, that have a UCD or candidate within three times their positional uncertainty. Then we examined all Gaia objects in the vicinity of these 96 X-ray sources and we associated them to the most plausible counterpart on the basis of their spatial separation to the X-ray position and their multiwavelength properties. This way we find 40 UCDs that have a secure identification with an X-ray source (that is bonafide UCD X-ray emitters) and 18 plausible UCD X-ray emitters for which we consider it likely that the X-ray source has its origin in the UCD. Twenty-one of the bonafide and plausible X-ray emitting UCDs have a spectroscopic confirmation, while the others have been selected based on Gaia photometry and we computed spectral types from the G–J color. The spectral types of the X-ray emitting UCDs and candidates range between M5 and M9. The distances of the eRASS1 UCDs range from 3.5 to 190 pc. The spectroscopically confirmed UCDs at the high end of the distance distribution are known to be members of nearby star forming regions. The majority of the UCDs from the eRASS1 sample show a ratio of X-ray to bolometric luminosity well above the canonical saturation limit of log (L x /Lbol) ≈ −3. For the two most extreme outliers, we verified the hypothesis that these high values are due to flaring activity through an analysis of the eRASS1 light curve. X-ray spectra could be analyzed for the two brightest objects in terms of count rate, both showing an emission-measure weighted plasma temperature of 〈 kT 〉 = 0.75 keV. These observations demonstrate the potential of eROSITA for advancing our knowledge on the faint coronal X-ray emission from UCDs by building statistical samples for which the average X-ray brightness, flares, and coronal temperatures can be derived.
A prosocial character of head-gaze aversion in common marmosets
2021-06-28

ABSTRACT Gaze aversion is a behavior adopted by several mammalian and non-mammalian species in response to eye contact and usually interpreted as reaction to perceived threat. Unlike many other primates, common marmosets ( Callithrix jacchus ) are thought to have high tolerance for direct gaze, barely exhibiting gaze avoidance towards conspecifics and humans. Here we show that this does not hold for marmosets interacting with a familiar experimenter who suddenly establishes eye contact in a playful interaction (“peek-a-boo”). In video footage synchronously recorded from the two agents, we found that our monkeys consistently alternated between eye contact and head-gaze aversion. The striking similarity with the gaze aversion’s dynamics exhibited by human infants interacting with their caregivers suggests a shared behavioral strategy to disengage temporarily from overwhelming social stimulation, in order to prepare for a new round of rewarding, affiliative face-to-face interaction. The potential of our finding for a marmoset model of autism is discussed.
Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring
2021-06-29

Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor.
Transmural Response and Transmural Healing Defined by Intestinal Ultrasound: New Potential Therapeutic Targets?
2021-06-29

Abstract Background and Aims Intestinal ultrasound [IUS] is a useful modality to monitor patients with inflammatory bowel disease [IBD]. Little is known about the use of IUS and appropriate definitions for transmural response [TR] and healing [TH]. We aimed to establish the use of IUS in monitoring TH as a potential target in routine medical practice. Methods Based on the prospective, non-interventional, multicentre studies TRUST and TRUST&amp;UC, we conducted a post-hoc analysis of 351 IBD patients with increased bowel wall thickness [BWT]. We analysed the rates of patients achieving TR and TH, comparing three definitions of TH. In 137 Crohn’s disease [CD] patients, the predictive value of TR and TH was investigated for the clinical and sonographic outcome at week 52. Results Within 12 weeks of treatment intensification, 65.6% [n = 118] of CD patients and 76.6% [n = 131] of ulcerative colitis [UC] patients showed a TR. Depending on the definition, 23.9–37.2% [n = 58/67/43] of CD patients and 45.0–61.4% [n = 90/105/77] of UC patients had TH at week 12. CD patients with TH were more likely to reach clinical remission at week 12 (odds ratio [OR] 3.33 [1.09–10.2]; p = 0.044) and a favourable sonographic outcome (OR 5.59 [1.97–15.8]; p = 0.001) at week 52 compared with patients without TH. Conclusions IUS response and TH in a relevant proportion of patients suggests that IUS is a useful method to assess transmural inflammatory activity in daily clinical practice. TR and TH are predictive for the sonographic outcome at week 52.
Robust cognitive load detection from wrist-band sensors
2021-06-29

In recent years, the detection of cognitive load has received a lot of attention. Understanding the circumstances in which cognitive load occurs and reliably predicting such occurrences, offers the potential for considerable advances in the field of Human-Computer Interaction (HCI). Numerous HCI applications, ranging from medical and health-related solutions to (smart) automotive environments, would directly benefit from the reliable detection of cognitive load. However, this task still remains highly challenging. We present a machine learning (ML) approach based on ensemble learning for robust cognitive load classification. The features used by the proposed solution are generated from the interpretation of physiological measurements (e.g., heart rate, r-r interval, skin temperature, and skin response) from a wearable device. Hence, our approach consists of two steps: (1) transforming the original data into discriminative features and (2) training an ensemble model to accurately and robustly predict cognitive load. The empirical results confirm that our method has a superior performance compared to various state-of-the-art baselines on the original and transformed data. Moreover, in the open-data CogLoad@UbiComp 2020 Competition, the proposed approach achieved the best results among 17 competing approaches and outperformed all participating competitors by a considerable margin.
Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria
2021-06-29

As the global effort to eradicate hepatitis B continues, immune escape mutations (IEMs) and drug resistance mutations (DRMs) affecting its diagnosis, treatment, and prevention are compromising this goal. However, knowledge about the prevalence and circulation of these mutations in Nigeria is scarce. Serum samples (n = 199) from apparently healthy prospective blood donors, pregnant women, and individuals presenting with fever in southwestern Nigeria were analyzed for the presence of IEMs and DRMs by means of nested PCR in the HBV S (HBs) and HBV polymerase (Pol) genes, followed by phylogenetic and mutational analyses. In total, 25.1% (n = 50/199) of samples were positive for HBV, as measured by PCR. In 41 samples (20.6%), both fragments could be amplified, whereas the HBs gene and the Pol gene fragment alone were detected in 0.5% (n = 1/199) and 4% (n = 8/199) of samples, respectively. Sequences were successfully obtained for all 42 HBs gene fragments but for only 31/49 Pol gene fragments (totaling 73 sequences from 44 individuals). All sequences were identified as HBV genotype E. IEMs were present in 18.2% (n = 8/44) of the sequences of HBV-positive individuals with available sequences. IEM Q129H was detected in eight out of the 44 (18.2%) HBV isolates sequenced in this study; however, no DRMs were observed. This study confirms the circulation of HBV IEMs and reports the presence of Q129H IEM for the first time in Nigeria. Intensified research on the dynamics of IEM is necessary in order to enhance the elimination of HBV.
Exposure to 16 Hz Pulsed Electromagnetic Fields Protect the Structural Integrity of Primary Cilia and Associated TGF-β Signaling in Osteoprogenitor Cells Harmed by Cigarette Smoke
2021-06-29

Cigarette smoking (CS) is one of the main factors related to avoidable diseases and death across the world. Cigarette smoke consists of numerous toxic compounds that contribute to the development of osteoporosis and fracture nonunion. Exposure to pulsed electromagnetic fields (PEMF) was proven to be a safe and effective therapy to support bone fracture healing. The aims of this study were to investigate if extremely low frequency (ELF-) PEMFs may be beneficial to treat CS-related bone disease, and which effect the duration of the exposure has. In this study, immortalized human mesenchymal stem cells (SCP-1 cells) impaired by 5% cigarette smoke extract (CSE) were exposed to ELF-PEMFs (16 Hz) with daily exposure ranging from 7 min to 90 min. Cell viability, adhesion, and spreading were evaluated by Sulforhodamine B, Calcein-AM staining, and Phalloidin-TRITC/Hoechst 33342 staining. A migration assay kit was used to determine cell migration. Changes in TGF-β signaling were evaluated with an adenoviral Smad2/3 reporter assay, RT-PCR, and Western blot. The structure and distribution of primary cilia were analyzed with immunofluorescent staining. Our data indicate that 30 min daily exposure to a specific ELF-PEMF most effectively promoted cell viability, enhanced cell adhesion and spreading, accelerated migration, and protected TGF-β signaling from CSE-induced harm. In summary, the current results provide evidence that ELF-PEMF can be used to support early bone healing in patients who smoke.
eROSITA detection of flares from the Be/X-ray binary A0538-66
2021-06-29

In 2018, XMM-Newton observed the awakening in X-rays of the Be/X-ray binary (Be/XRB) A0538-66. It showed bright and fast flares close to periastron with properties that had never been observed in other Be/XRBs before. We report the results from the observations of A0538-66 collected during the first all-sky survey of eROSITA, an X-ray telescope (0.2-10 keV) on board the Spektrum-Roentgen-Gamma satellite. eROSITA caught two flares within one orbital cycle at orbital phases φ = 0.29 and φ = 0.93 (where φ = 0 corresponds to periastron), with peak luminosities of ~2-4 × 10 36 erg s -1 (0.2-10 keV) and durations of 42 ≤ Δ t fl ≤ 5.7 × 10 4 s. The flare observed at φ ≈ 0.29 shows that the neutron star can accrete considerably far from periastron, although it is expected to be outside of the circumstellar disk, thus providing important new information about the plasma environment surrounding the binary system. We also report the results from the photometric monitoring of A0538-66 carried out with the REM, OGLE, and MACHO telescopes from January 1993 until March 2020. We found that the two sharp peaks that characterize the orbital modulation in the optical occur asymmetrically in the orbit, relative to the position of the donor star.
Restoration of ecosystem functions: Seed production in restored and ancient grasslands
2021-06-29

Abstract Questions Evaluating seed production as a community function in species‐rich temperate grasslands, we asked: (a) do ancient and restored grasslands differ in the composition of seed‐producing species; (b) do seed‐producing species of ancient and restored grasslands differ in their functional traits and habitat origin of their species; and (c) how does seed production change during the season considering management and is seed production different for the whole community and for the subset of species occurring in both types of grasslands? Location White Carpathian Mountains (Czech Republic). Methods We assessed the species composition of flowering and fruiting species and collected propagule samples from three ancient and three restored grasslands. From the measured parameters, we estimated seed production for particular fruiting species. We combined these reproductive parameters with data on plant traits and plant status. Results Flowering species in restored grasslands produced three times higher seed numbers and three times lower seed mass than flowering species in ancient grasslands. At ancient sites, most seeds belonged to meadow specialist species; at restored sites, seeds of ruderal and generalist species prevailed. Prior to mowing, in both grassland types the seed‐producing species were characterised by a high capability of clonal reproduction, high leaf dry matter content, and wind pollination. After mowing, seed‐producing species were insect‐pollinated species at ancient sites. This reflects the dominance of grasses before mowing and of forbs after mowing. Conclusions Higher seed number, lower seed mass and lower reliance on pollinators in restored grasslands indicate a different ecosystem functionality related to these parameters, in comparison with ancient grasslands. Specifically, seeds act as source for generative regeneration of resident species while resources for pollinators and seed herbivores are reduced. This maintains a differentiation of restored and ancient grasslands not only in terms of species composition but also in their effect on other trophic levels.
Vortex Transport Entropy in cuprate superconductors and Boltzmann Constant
2021-06-29

The vortex transport entropy in the mixed state of the cuprate superconductors YBa Cu O and Bi Sr CaCu O at the maximum Nernst or Ettingshausen signal below is discussed. The vortex transport entropy per CuO double layer in the cuprate epitaxial films is found to be close to the Boltzmann constant.
Unrecognized introduction of SARS‐CoV‐2 variants of concern to Central Africa: Import and local transmission of B.1.1.7 in Gabon in the very early stage of the variant spread to the African continent
2021-06-29

Abstract The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variant of concern with higher infectivity has already resulted in the enormous increase in infection cases worldwide. We report an unrecognized introduction of the variant B.1.1.7 in Gabon in December 2020, which was the initial phase of the variant introduction to Africa. The B.1.1.7 variant was also detected in a hospitalized patient in January 2021, indicating a rapid spread of the variant in Gabon since its first detection. Phylogenetic analysis revealed that the detected B.1.1.7 variants originated from the distinct regions, strongly suggesting that the B.1.1.7 variant had been repeatedly introduced to Gabon since December 2020. These results provide insights on the unrecognized risks of infections with variants of concern, and show the necessity to conduct continuous genomic monitoring for immediate alert and control of novel SARS‐CoV‐2 variant infections.
Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset
2021-06-30

Comparing the impact of the COVID-19 pandemic between countries or across time is difficult because the reported numbers of cases and deaths can be strongly affected by testing capacity and reporting policy. Excess mortality, defined as the increase in all-cause mortality relative to the expected mortality, is widely considered as a more objective indicator of the COVID-19 death toll. However, there has been no global, frequently updated repository of the all-cause mortality data across countries. To fill this gap, we have collected weekly, monthly, or quarterly all-cause mortality data from 103 countries and territories, openly available as the regularly updated World Mortality Dataset. We used this dataset to compute the excess mortality in each country during the COVID-19 pandemic. We found that in several worst-affected countries (Peru, Ecuador, Bolivia, Mexico) the excess mortality was above 50% of the expected annual mortality (Peru, Ecuador, Bolivia, Mexico) or above 400 excess deaths per 100,000 population (Peru, Bulgaria, North Macedonia, Serbia). At the same time, in several other countries (e.g. Australia and New Zealand) mortality during the pandemic was below the usual level, presumably due to social distancing measures decreasing the non-COVID infectious mortality. Furthermore, we found that while many countries have been reporting the COVID-19 deaths very accurately, some countries have been substantially underreporting their COVID-19 deaths (e.g. Nicaragua, Russia, Uzbekistan), by up to two orders of magnitude (Tajikistan). Our results highlight the importance of open and rapid all-cause mortality reporting for pandemic monitoring.
Isomer Selective Comprehensive Lipidomics Analysis of Phosphoinositides in Biological Samples by Liquid Chromatography with Data Independent Acquisition Tandem Mass Spectrometry
2021-06-30

Phosphoinositides (PIPx) play central roles in membrane dynamics and signal transduction of key functions like cellular growth, proliferation, differentiation, migration, and adhesion. They are highly regulated through a network of distinct phosphatidylinositol phosphates consisting of seven groups and three regioisomers in two groups (PIP and PIP2), which arise from phosphorylation at 3', 4', and 5' positions of the inositol ring. Numerous studies have revealed the importance of both fatty acyl chains, degree of phosphorylation, and phosphorylation positions under physiological and pathological states. However, a comprehensive analytical method that allows differentiation of all regioisomeric forms with different acyl side chains and degrees of phosphorylation is still lacking. Here, we present an integrated comprehensive workflow of PIPx analysis utilizing a chiral polysaccharide stationary phase coupled with electrospray ionization high-resolution mass spectrometry with a data independent acquisition technique using the SWATH technology. Correspondingly, a targeted data mining strategy in the untargeted comprehensively acquired MS and MS/MS data was developed. This powerful highly selective method gives a full picture of PIPx profiles in biological samples. Herein, we present for the first time the full PIPx profiles of NIST SRM1950 plasma, <i>Pichia pastoris</i> lipid extract, and HeLa cell extract, including profile changes upon treatment with potential PI3K inhibitor wortmannin. We also illustrate using this inhibitor that measurements of the PIPx profile averaged over the distinct regioisomers by analytical procedures, which cannot differentiate between the individual PIPx isomers, can easily lead to biased conclusions.
Academic Self-Regulation, Chronotype and Personality in University Students During the Remote Learning Phase due to COVID-19
2021-06-30

During the COVID-19 shutdown phase in Germany, universities stopped presence teaching and students had to turn to digital instruction. To examine their capability to cope with the changed learning situation, we assessed how basic psychological need satisfaction and frustration, motivational regulation, vitality, and self-efficacy of 228 German biology-teaching students (75% female) relate to their chronotype and personality (Big Five). Specifically, we were interested in possible effects of chronotype and personality dimensions on variables related to successful remote learning. Since the pandemic and remote learning will accompany teaching and learning at university in 2021, predictors of successful remote learning need to be identified to support student learning optimally in digital learning environments. In our study, morning-oriented, conscientious, and open students with low neuroticism seem to better cope with the shutdown environment due to vitality, self-efficacy, and partly their self-determined motivation. Moreover, our findings implicate students might need different support depending on their chronotype and personality during the digital learning phase.
Increased Entropic Brain Dynamics during DeepDream-Induced Altered Perceptual Phenomenology
2021-06-30

In recent years, the use of psychedelic drugs to study brain dynamics has flourished due to the unique opportunity they offer to investigate the neural mechanisms of conscious perception. Unfortunately, there are many difficulties to conduct experiments on pharmacologically-induced hallucinations, especially regarding ethical and legal issues. In addition, it is difficult to isolate the neural effects of psychedelic states from other physiological effects elicited by the drug ingestion. Here, we used the DeepDream algorithm to create visual stimuli that mimic the perception of hallucinatory states. Participants were first exposed to a regular video, followed by its modified version, while recording electroencephalography (EEG). Results showed that the frontal region’s activity was characterized by a higher entropy and lower complexity during the modified video, with respect to the regular one, at different time scales. Moreover, we found an increased undirected connectivity and a greater level of entropy in functional connectivity networks elicited by the modified video. These findings suggest that DeepDream and psychedelic drugs induced similar altered brain patterns and demonstrate the potential of adopting this method to study altered perceptual phenomenology in neuroimaging research.