julilili42/papers huggingface dataset:
The Santa Filomena meteorite shower: Trajectory, classification, and opaque phases as indicators of metamorphic conditions
2023-04-12

Abstract On August 19, 2020, at 13:18—UTC, a meteor event ended as a meteorite shower in Santa Filomena, a city in the Pernambuco State, northeast Brazil. The heliocentric orbital parameters resulting from images by cameras of the weather broadcasting system were semimajor axis a = 2.1 ± 0.1 au, eccentricity e = 0.55 ± 0.03, and inclination i = 0.15 o ± 0.05. The data identified the body as an Apollo object, an Earth‐crossing object with a pericenter interior to the Earth's orbit. The chemical, mineralogical, and petrological evaluations, as well as the physical analysis, followed several traditional techniques. The meteorite was identified as a H5‐6 S4 W0 ordinary chondrite genomict breccia. The large amount of metal in the meteorite made a metallographic evaluation based on the opaque phases possible. The monocrystalline kamacite crystals suggest a higher petrological type and the distorted Neumann lines imply at least two different shock events. The absence of the plessite phase shows that the meteorite did not reach the highest shock levels S5 and S6. The well‐defined polycrystalline taenite is indicative of petrologic types 4 and 5 due to the conserved internal tetrataenite rim at the boundaries. The presence of polycrystalline taenites and the characteristics of the Agrell Effect suggest that the Santa Filomena meteorite did not reheat above 700°C. The absence of martensite confirms reheating temperatures &lt;800°C and a slow cooling rate. The Ni contents and sizes of the zoned taenite particles indicate a slow cooling rate ranging from 1 to 10 K Myr −1 .
Fairness as adequacy: a sociotechnical view on model evaluation in machine learning
2023-04-12

Abstract This paper develops an account of model evaluation—with an emphasis on fairness concerns—that takes the social situatedness of ML models as its starting point. Such a view entails that ML models are not deemed isolated entities, but rather tools, used for specific purposes and potentially impacting their social environment in manifold ways. This shift of perspective opens up a new problem space and facilitates rethinking criteria for model evaluation. By drawing on the adequacy-for-purpose view in philosophy of science, epistemic norms and desiderata for an adequate deployment of ML models along the dimensions of Social Objectives, Measurement, Social Dynamics, and interaction are then identified. The account thus developed also highlights why any auditing of ML models that ought to assist in consequential decision-making cannot be limited to an assessment of statistical properties, but needs to incorporate a variety of methods from the social sciences instead. Moreover, while the process of model evaluation might be deemed as a mere technical exercise, it is in fact riddled by epistemic and morally normative considerations.
Muscular Fatigue and Quadriceps-to-Hamstring Ratio in Alpine Skiing in Women over 40 Years
2023-04-12

(1) Background: In alpine skiing, senior athletes and especially women have a high risk of knee injury. This may also be related to muscular fatigue (MF) of the knee-stabilizing thigh muscles. This study investigates both the evolution of muscle activity (MA) and of MF of the thighs throughout an entire skiing day. (2) Methods: n = 38 female recreational skiers over 40 years of age performed four specific skiing tasks (plough turns, V-steps uphill, turns with short, and middle radii) at specific times, while freely skiing the rest of the day. Surface EMG of the thigh muscle groups (quadriceps and hamstrings) was measured using special wearables (EMG pants). Apart from standard muscle activity parameters, the EMG data were also processed in the frequency domain to calculate the mean frequency and its shift over the day as a metric of muscle fatigue. (3) Results: The EMG pants showed reliable signal quality over the entire day, with BMI not impacting this. MF increased during skiing before and for both muscle groups significantly (p &lt; 0.006) during lunch. MF, however, was not reflected in the quadriceps–hamstrings ratio. The plough manoeuvre seems to require significantly (p &lt; 0.003) more muscle dynamics than the three other tasks. (4) Conclusion: MF may be quantified over an entire skiing day and thus fatigue information could be given to the skier. This is of major importance for skiers at the beginner level dominantly performing plough turns. Crucial for all skiers: There is no regenerative effect of a 45-min lunch break.
Variation and development of the turtle chondrocranium, with a description of the common musk turtle (Sternotherus odoratus, Kinosternidae, Cryptodira, Testudines)
2023-04-12

Abstract Based on histological cross‐sections, the chondrocranium of the common musk turtle ( Sternotherus odoratus ) was reconstructed, described, and compared with other turtles. It differs from that of other turtle chondrocrania by possessing elongated, slightly dorsally orientated nasal capsules with three dorsolateral foramina, which might be homologous to the foramen epiphaniale, and by having an enlarged crista parotica. Additionally, the posterior part of the palatoquadrate is more elongated and more slender than in other turtles, while its ascending process is connected to the otic capsule by appositional bone. The proportions of the chondrocranium were also compared with those of “mature” chondrocrania of other turtle species in a Principal Component Analysis (PCA). Other than expected, the S. odoratus chondrocranium is not similar in proportions to those of chelydrids, the closest related species in the sample. The results indicate to differences in the proportions among larger turtle clades (e.g., Durocryptodira, Pleurodira, and Trionychia). S. odoratus is an exception to this pattern since it shows elongated nasal capsules similar to the trionychid Pelodiscus sinensis . A second PCA comparing the chondrocranial proportions of multiple developmental “stages” mostly shows differences between trionychids and all other turtles. S. odoratus is again similar to trionychids along PC1, but its proportions are the most similar along PC2 and PC3 to older “stages” of americhelydians, including the chelydrid Chelydra serpentina , which is related to chondrocranium height and quadrate width. We discuss potential ecological correlations of our findings mirrored in late embryonic stages.
Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment
2023-04-12

Abstract Despite tremendous progress in deciphering breast cancer at the genomic level, the pronounced heterogeneity remains a major obstacle to the advancement of novel and more effective treatment approaches. Frequent treatment failure and the development of treatment resistance highlight the need for patient-derived tumor models that reflect the individual tumors of breast cancer patients and allow a comprehensive analyses and parallel functional validation of individualized and therapeutically targetable vulnerabilities in protein signal transduction pathways. Here, we introduce the generation and application of breast cancer patient-derived 3D microtumors (BC-PDMs). Residual fresh tumor tissue specimens were collected from n = 102 patients diagnosed with breast cancer and subjected to BC-PDMs isolation. BC-PDMs retained histopathological characteristics, and extracellular matrix (ECM) components together with key protein signaling pathway signatures of the corresponding primary tumor tissue. Accordingly, BC-PDMs reflect the intertumoral heterogeneity of breast cancer and its key signal transduction properties. DigWest®-based protein expression profiling of identified treatment responder and non-responder BC-PDMs enabled the identification of potential resistance and sensitivity markers of individual drug treatments, including markers previously associated with treatment response and yet undescribed proteins. The combination of individualized drug testing with comprehensive protein profiling analyses of BC-PDMs may provide a valuable complement for personalized treatment stratification and response prediction for breast cancer.
The revolution that still isn't: The origins of behavioral complexity in Homo sapiens
2023-04-13

The behavioral origins of Homo sapiens can be traced back to the first material culture produced by our species in Africa, the Middle Stone Age (MSA). Beyond this broad consensus, the origins, patterns, and causes of behavioral complexity in modern humans remain debated. Here, we consider whether recent findings continue to support popular scenarios of: (1) a modern human 'package,' (2) a gradual and 'pan-African' emergence of behavioral complexity, and (3) a direct connection to changes in the human brain. Our geographically structured review shows that decades of scientific research have continuously failed to find a discrete threshold for a complete 'modernity package' and that the concept is theoretically obsolete. Instead of a continent-wide, gradual accumulation of complex material culture, the record exhibits a predominantly asynchronous presence and duration of many innovations across different regions of Africa. The emerging pattern of behavioral complexity from the MSA conforms to an intricate mosaic characterized by spatially discrete, temporally variable, and historically contingent trajectories. This archaeological record bears no direct relation to a simplistic shift in the human brain but rather reflects similar cognitive capacities that are variably manifested. The interaction of multiple causal factors constitutes the most parsimonious explanation driving the variable expression of complex behaviors, with demographic processes such as population structure, size, and connectivity playing a key role. While much emphasis has been given to innovation and variability in the MSA record, long periods of stasis and a lack of cumulative developments argue further against a strictly gradualistic nature in the record. Instead, we are confronted with humanity's deep, variegated roots in Africa, and a dynamic metapopulation that took many millennia to reach the critical mass capable of producing the ratchet effect commonly used to define contemporary human culture. Finally, we note a weakening link between 'modern' human biology and behavior from around 300 ka ago.
Stabilization of mineral-associated organic carbon in Pleistocene permafrost
2023-04-13

Abstract Ice-rich Pleistocene-age permafrost is particularly vulnerable to rapid thaw, which may quickly expose a large pool of sedimentary organic matter (OM) to microbial degradation and lead to emissions of climate-sensitive greenhouse gases. Protective physico-chemical mechanisms may, however, restrict microbial accessibility and reduce OM decomposition; mechanisms that may be influenced by changing environmental conditions during sediment deposition. Here we study different OM fractions in Siberian permafrost deposited during colder and warmer periods of the past 55,000 years. Among known stabilization mechanisms, the occlusion of OM in aggregates is of minor importance, while 33-74% of the organic carbon is associated with small, &lt;6.3 μm mineral particles. Preservation of carbon in mineral-associated OM is enhanced by reactive iron minerals particularly during cold and dry climate, reflected by low microbial CO 2 production in incubation experiments. Warmer and wetter conditions reduce OM stabilization, shown by more decomposed mineral-associated OM and up to 30% higher CO 2 production. This shows that considering the stability and bioavailability of Pleistocene-age permafrost carbon is important for predicting future climate-carbon feedback.
Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form
2023-04-13

Abstract Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown. Here, we show that plasticity of nematode mouth forms is determined by histone 4 lysine 5 and 12 acetylation (H4K5/12ac). Acetylation in early larval stages provides a permissive chromatin state, which is susceptible to induction during the critical window of environmental sensitivity. As development proceeds deacetylation shuts off switch gene expression to end the critical period. Inhibiting deacetylase enzymes leads to fixation of prior developmental trajectories, demonstrating that histone modifications in juveniles can carry environmental information to adults. Finally, we provide evidence that this regulation was derived from an ancient mechanism of licensing developmental speed. Altogether, our results show that H4K5/12ac enables epigenetic regulation of developmental plasticity that can be stored and erased by acetylation and deacetylation, respectively.
Multitask Learning for Activity Detection in Neovascular Age-Related Macular Degeneration
2023-04-13

By improving nAMD activity detection performance and transparency of automated decisions, multitask DNNs can support the translation of machine learning research into clinical decision support systems for nAMD activity detection.
Data sharing upon request and statistical consistency errors in psychology: A replication of Wicherts, Bakker and Molenaar (2011)
2023-04-13

Sharing research data allows the scientific community to verify and build upon published work. However, data sharing is not common practice yet. The reasons for not sharing data are myriad: Some are practical, others are more fear-related. One particular fear is that a reanalysis may expose errors. For this explanation, it would be interesting to know whether authors that do not share data genuinely made more errors than authors who do share data. (Wicherts, Bakker and Molenaar 2011) examined errors that can be discovered based on the published manuscript only, because it is impossible to reanalyze unavailable data. They found a higher prevalence of such errors in papers for which the data were not shared. However, (Nuijten et al. 2017) did not find support for this finding in three large studies. To shed more light on this relation, we conducted a replication of the study by (Wicherts et al. 2011). Our study consisted of two parts. In the first part, we reproduced the analyses from (Wicherts et al. 2011) to verify the results, and we carried out several alternative analytical approaches to evaluate the robustness of the results against other analytical decisions. In the second part, we used a unique and larger data set that originated from (Vanpaemel et al. 2015) on data sharing upon request for reanalysis, to replicate the findings in (Wicherts et al. 2011). We applied statcheck for the detection of consistency errors in all included papers and manually corrected false positives. Finally, we again assessed the robustness of the replication results against other analytical decisions. Everything taken together, we found no robust empirical evidence for the claim that not sharing research data for reanalysis is associated with consistency errors.
Clinical Significance of Diffusion Tensor Imaging in Metachromatic Leukodystrophy
2023-04-13

Abstract Background Metachromatic leukodystrophy (MLD) is a lysosomal enzyme deficiency disorder leading to progressive demyelination and, consecutively, to cognitive and motor decline. Brain magnetic resonance imaging (MRI) can detect affected white matter as T2 hyperintense areas but cannot quantify the gradual microstructural process of demyelination more accurately. Our study aimed to investigate the value of routine MR diffusion tensor imaging in assessing disease progression. Methods MR diffusion parameters (apparent diffusion coefficient [ADC] and fractional anisotropy [FA]) were in the frontal white matter, central region (CR), and posterior limb of the internal capsule in 111 MR datasets from a natural history study of 83 patients (age: 0.5–39.9 years; 35 late-infantile, 45 juvenile, 3 adult, with clinical diffusion sequences of different scanner manufacturers) as well as 120 controls. Results were correlated with clinical parameters reflecting motor and cognitive function. Results ADC values increase and FA values decrease depending on disease stage/severity. They show region-specific correlations with clinical parameters of motor and cognitive symptoms, respectively. Higher ADC levels in CR at diagnosis predicted a disease course with more rapid motor deterioration in juvenile MLD patients. In highly organized tissues such as the corticospinal tract, in particular, diffusion MR parameters were highly sensitive to MLD-associated changes and did not correlate with the visual quantification of T2 hyperintensities. Conclusion Our results show that diffusion MRI can deliver valuable, robust, clinically meaningful, and easily obtainable/accessible/available parameters in the assessment of prognosis and progression of MLD. Therefore, it provides additional quantifiable information to established methods such as T2 hyperintensity.
Bioelectrical impedance analysis in the BaSAlt cohort-study: the phase angle as an additional parameter for sarcopenia quantification among German nursing home residents?
2023-04-13

Abstract Purpose Sarcopenia is characterized by the loss of muscle mass, strength, and physical functioning. The bioelectrical impedance analysis (BIA) is a simplify method for the measurement of muscle quantity and quality. But there is a lack of evidence in the interpretation of the muscle quality parameter phase angle (PhA), which was recommended by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). We hypothesize that the PhA shows differences between sarcopenia categorized groups and can be used as an additional parameter for sarcopenia quantification among residents of nursing homes (NH). Methods Based on EWGSOP2 specifications, 78 residents from five German NH was categorized into sarcopenia groups. Group comparisons with Kruskal–Wallis tests, Dunn–Bonferroni post-hoc-Tests, and correlations with Spearman coefficients were conducted with the muscle quality parameter PhA. Results Significant group differences by Kruskal–Wallis test for PhA was detected ( H = 8.150, p = 0.017). The Dunn–Bonferroni post-hoc-Test showed significant results by group comparison for “confirmed/ severe sarcopenia” (4.1° [3.1–5.0]) with “no sarcopenia” (4.6° [3.7–11.2]; p =0 .049) and “probable sarcopenia” (4.7° [3.4–13.5]; p = 0.016), respectively. Conclusions There is a limitation for differentiation in preliminary stage of sarcopenia among multimorbid NH residents by PhA. Moreover, further research for specific cut-off-values and the individual sarcopenia progression monitoring by PhA are needed. Trial registration No. AZ A2.5.4-096_aa (Date of approval: July 2019).
Organic matter influence on ooid formation: New insights into classic examples (Great Salt Lake, USA; Triassic Germanic Basin, Germany)
2023-04-13

Abstract Ooids are particles composed of a tangential or radial cortex growing around a nucleus. They are common in carbonate deposits of almost any geological age and provide insights into environmental conditions. However, abiotic or biotic factors influencing their formation remain unclear. This study aims to advance our understanding of ooid formation with a multi- analytical approach (e.g., FE-SEM, Raman spectroscopy, μ-XRF) to classic examples from Great Salt Lake (GSL; USA) and the Lower Triassic Germanic Basin (GB; Germany). Both deposits represent hypersaline shallow-water environments where ooids are closely associated with microbial mats. GSL ooids are dominantly 0.2–1 mm in size, ellipsoidal to subspherical in shape, composed of aragonite, and contain organic matter (OM). GB ooids are mainly ≤4 mm in size, spherical to subspherical in shape, composed of calcite, and currently contain little OM. Despite the differences, both ooids have the same cortex structures, likely reflecting similar formation processes. Some GSL ooids formed around detrital grains while others exhibit micritic particles in their nuclei. In GB ooids, detrital nuclei are rare, despite the abundance of siliciclastic particles of various sizes in the host rocks. GB deposits also include “compound ooids”, i.e., adjacent ooids that coalesced with each other during growth, suggesting static in-situ development, which is supported by the lack of detrital grains as nuclei. GB ooids also grew into laminated microbial crusts with identical microstructures, further indicating a static formation. Such microbial crusts typically form through mineral precipitation associated with OM (e.g., extracellular polymeric substances), suggesting a similar formation pathway for ooids. The inferred key-role of OM is further supported by features in radial ooids from the GSL, which commonly exhibit, from their nuclei towards their surface, increasing OM contents and decreasing calcification.
Thermally Ultra-Robust S = ½ Tetrazolinyl Radicals: Synthesis, Electronic Structure, Magnetism, and Nanoneedle Assemblies on Silicon Surface.
2023-04-13

Open-shell organic molecules, including S = 1⁄2 radicals, may provide enhanced properties for several emerging technologies, however, relatively few synthesized to date possess robust thermal stability and processability. We report synthesis of S = 1⁄2 biphenylene-fused tetrazolinyl radicals 1 and 2. Both radicals possess near-perfect planar structures based on their X-ray structures and DFT computations. Radical 1 possesses an outstanding thermal stability as indicated by the onset of decomposition at 269 °C, based on thermogravimetric analysis (TGA) data. Both radicals possess very low oxidation potentials &lt; 0 V (vs. SCE) and their electrochemical energy gaps, Ecell 0.9 eV, are rather low. Magnetic properties of polycrystalline 1 are characterized by SQUID magnetometry revealing a one-dimensional S = 1⁄2 antiferromagnetic Heisenberg chain with exchange coupling constant J’/k –22.0 K. Radical 1 in toluene glass possesses a long electron spin coherence time, Tm ≈ 7 μs in the 40 – 80 K temperature range, a property advantageous for potential applications as a molecular spin qubit. Radical 1 is evaporated under ultrahigh vacuum (UHV) forming assemblies of intact radicals on a silicon substrate, as confirmed by high-resolution X-ray photoelectron spectroscopy (XPS). Scanning electron microscope (SEM) images indicate that the radical molecules form nanoneedles on the substrate. The nanoneedles are stable for at least 64 hours under air as monitored by using X-ray photoelectron spectroscopy. EPR studies of the thicker assemblies, prepared by UHV evaporation, indicate radical decay according to first-order kinetics with a long half-life of 50 +/-4 days at ambient conditions.
Halophilic nematodes live in America’s Dead Sea
2023-04-13

Abstract Extremophiles can reveal the origins of life on Earth and the possibility of life elsewhere. Most identified extremophiles are single-cell microbes, leaving gaps in our knowledge concerning the origins and habitable limits of multicellular organisms. Here, we report the recovery of roundworms (Phylum Nematoda) from the Great Salt Lake (GSL), UT, a hypersaline lake referred to as “America’s Dead Sea”. Nematodes were found primarily in microbialites, benthic organosedimentary structures once abundant on early Earth. 16S sequencing of individual nematodes revealed a diverse bacterial community distinct from its surrounding habitat. Phylogenetic divergence compared to Owens Lake, another terminal lake in the Great Basin, suggests that GSL nematodes represent multiple previously undescribed species. These findings update our understanding of halophile ecosystems and the habitable limit of animals. One-Sentence Summary We report the discovery of novel halophilic nematodes in microbialites of the Great Salt Lake, UT.