julilili42/papers huggingface dataset:
Non-invasive-physical-plasma treatment of low- and high-grade cervical intraepithelial neoplasia: a non-invasive and anaesthesia-independent treatment procedure evaluated in a prospective, monocentric clinical trial
2020-10-01

Introduction Cervical intraepithelial neoplasia (CIN) are serious precursors for cervical cancer (CC) and show the highest incidence in young females. Current treatment procedures (ST) are very invasive, however, only the minority of CIN will progress into CC. Thus, over-treatment is a severe problem for affected women, health specialists and health-economy. Here, non-invasive-physical-plasma (NIPP) was evaluated as a non-invasive, painless and ambulatory treatment alternative for low- and high grade CIN lesions.
Financing Costs of State-owned Enterprises: Evidence from EU Firm Level Data
2020-10-01

How are investment decisions affected by whether companies are private or (partly) state-owned (SOE)? In a recent and extensive EU firm-level dataset, including non-listed firms, we apply an endogenous selection model to compare capital costs for SOEs and private firms similar in financial characteristics. As a first result, we found that SOEs had lower capital costs compared to private firms. Secondly, we examined how firm profitability as a proxy of a firm’s default risk affected capital costs. We found that capital costs of private firms, but not of SOEs, were negatively affected by profitability. We argue that state guarantees are an insufficient explanation for this later finding as in the EU these state guarantees reduce, but do not eliminate the risk of default for SOEs. We speculate that financing costs might be affected by other differences between private firms and SOEs that affect lender’s and investor’s preferences.
Conducting High-Spin (S = 1) Organic Diradical with Robust Stability
2020-10-01

Triplet ground-state organic molecules are of interest with respect to several emerging technologies but usually show limited stability, especially, as thin films. We report an organic diradical, based entirely on two Blatter radicals, that possesses triplet ground state (2J/k ≈ 220 K, EST ≈ 0.4 kcal mol-1 ) and robust stability, with onset of decomposition above 264 C (TGA). Polycrystalline diradical is a good electrical conductor with conductivity comparable to the out-of-plane conductivity in highly oriented pyrolytic graphite (HOPG). The diradical is evaporated under ultra-high vacuum to form thin films, which are stable on air for at least 18 and 48 h, as demonstrated by X-ray photoelectron and electron paramagnetic resonance (EPR) spectroscopies, respectively.
Patella height assessment in total knee Arthroplasty: Simple adaptation of the Caton-Deschamps index might be sufficient
2020-10-01

Multiple patella height indices exist. For application in Arthroplasty detection of not only true patella infera but also pseudo patella infera seems to be important. A modification to the original Caton-Deschamps Index could maintain its principles and detect pseudo patella infera in knee Arthroplasty.
Stationary solution for distortion-products in two-dimensional cochlear model with inhomogeneities
2020-10-01

Vetešník and Gummer [J. Acoust. Soc. Am. 131, 3914–3934 (2012)] obtained a stationary solution for distortion products (DPs) in a two-dimensionalcochlear model in which the impedance of the basilar membrane varied smoothly along its length. Their solution was used to study the dependence of the nonlinear-distortion source of distortion-product otoacoustic emission (DPOAE) on stimulus level [Vencovský et al., J. Acoust. Soc. Am. 145, 2909–2931 (2019); Vencovský et al., J. Acoust. Soc. Am. 146, EL92–EL98 (2019)]. Here, the solution is extended to “impedance irregularities” in the mechanics of the cochlea causing the generation of the coherent-reflection source of DPOAEs near the DP characteristic place. The coherent-reflection source of DPOAEs can be relatively pronounced in normal-hearing humans and the interference between the nonlinear-distortion and coherent-reflection components complicates the use of DPOAEs in routine clinical screening of the auditory periphery. The solution for the model with mechanical perturbation can be used to study the relationship between nonlinear-distortion and coherent-reflection components of DPOAEs.
Paul Silas Peterson: „Zurück zur Individualität!“ Die Rezeption moderner Religionsphilosophie im Hochland in der Weimarer Zeit
2020-10-01

Abstract The monthly magazine Hochland was probably the most influential Catholic cultural periodical in Germany in the Weimar Period. According to Georg Cardinal von Kopp’s assessment in 1911, it was “unfortunately the most read periodical in all of the educated circles of Germany, Austria and German Switzerland”. Moving beyond the simple rejection of modern culture in Germany, the journal tried to follow a new program of mediatory engagement, although it did continue to hold to traditional positions in many regards. In this article the reception of modern, Enlightenment-affirmative philosophy of religion in the journal is introduced with reference to reviews and essays from the later 1910s to the early 1930s. The journal’s treatment of a few critical subject areas is given close interpretive analysis, including the journal’s treatment of Gertrud Simmel’s Über das Religiöse , individually conceptualized forms of personalist moral theory, and the general shift to phenomenological discourses and the individual in the philosophy of religion. The fundamental rejections of these ideas and these schools of thought in reviews and essays, which are also found in the journal at this time (as in most all German language Catholic cultural journals of the period), are not addressed in this article. The article thus sheds light on an often-forgotten and relatively small minority phenomenon in German Catholic intellectual circles of the Weimar Period, namely the positive embrace of Enlightenment-oriented modern thought. By promoting these ideas at this time, this group made themselves highly vulnerable to disciplinary measures by the Catholic Church. (The journal was put on the Index in 1911.)
Conducting High-Spin (S = 1) Organic Diradical with Robust Stability
2020-10-01

Triplet ground-state organic molecules are of interest with respect to several emerging technologies but usually show limited stability, especially, as thin films. We report an organic diradical, based entirely on two Blatter radicals, that possesses triplet ground state (2J/k ≈ 220 K, EST ≈ 0.4 kcal mol-1 ) and robust stability, with onset of decomposition above 264 C (TGA). Polycrystalline diradical is a good electrical conductor with conductivity comparable to the out-of-plane conductivity in highly oriented pyrolytic graphite (HOPG). The diradical is evaporated under ultra-high vacuum to form thin films, which are stable on air for at least 18 and 48 h, as demonstrated by X-ray photoelectron and electron paramagnetic resonance (EPR) spectroscopies, respectively. &lt;br&gt;
Call for Review Papers: Tissue Engineering, Part B
2020-10-01

As we continue to navigate the disruption of the COVID-19 outbreak, Tissue Engineering, Part B: Reviews (IF 6.512) would like to personally invite all researchers in the field to submit their review papers for prompt and thorough consideration in the journal.Many researchers are currently experiencing multiple changes in their academic routines as presented by the COVID-19 pandemic.This is why the Editors-in-Chief of Tissue Engineering, Part B: Reviews would like to issue an open call for review articles to be given thorough, expedited review and consideration in the journal.Reviews of exceptional merit will receive an additional benefit of a global press release announcement highlighting their research to the global Tissue Engineering audience around the world, and
New taxa of the water mite family Limnocharidae (Actinotrichida: Eylaoidea) parasitising tropical water bugs of the genus Rhagovelia Mayr, 1865 (Hemiptera: Veliidae) reveal unsuspected diversity of larval morphologies
2020-10-01

© 2020 Informa UK Limited, trading as Taylor &amp; Francis Group. The larval stage of Neolimnochares johnstoni Smith and Cook, 2005 is first described in detail, and the larva of a similar undescribed species, Neolimnochares sp. B, see Table 1, is recorded from Peru. Larvae attributed to Limnochares (Cyclothrix) australica Lundblad, 1941a by Martin and Smit (2002) are considered to belong to Neolimnochares Lundblad, 1941c. Neolimnocharinae subfam. n. is proposed and discussed. For larvae assigned to this subfamily, parasitic on veliid water bugs (Rhagovelia Mayr, 1865) and with extraordinary morphological modifications, new taxa are proposed: Veliacola gen. n., (V. mirificus sp. n., Madagascar); Archaeveliacola gen. n. (A. papuanus sp. n., Indonesia, A. smiti sp. n., Australia); Armaveliacola gen. n. (A. rhagoveliae sp. n., Madagascar, A. major sp. n., Madagascar, A. minor sp. n., Cameroon, Kenya); Isoveliacola gen. n. (I. costaricensis sp. n., Costa Rica, I. borneoensis sp. n., Indonesia). Additional records are: Veliacola sp. (Dominican Republic), Archaeveliacola sp. (Bolivia), and Isoveliacola sp. (Belize). Neolimnochares (Paracyclothrix) Lundblad, 1967 is synonymised with Limnochares (Cyclothrix) Wolcott, 1905, resulting in Limnochares (Cyclothrix) hyaliniseta (Lundblad, 1969) comb. n., and L. (C.) longimaxillaris (Lundblad, 1969) comb. n. (both Myanmar). LSID: http://www.zoobank.org/urn:lsid:zoobank.org:pub:275E6D4B-98E7-4A26-B7C7-DABCCF73A9EA.
Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor–Positive Breast Cancer Patients
2020-10-02

Abstract Purpose: Patients with estrogen receptor– and/or progesterone receptor–positive, early breast cancer benefit from hormonal treatment, yet high global death burdens due to high prevalence and long-term recurrence risk call for biomarkers to guide additional treatment approaches. Experimental Design: From a prospective, observational study of postmenopausal early breast cancer patients treated with tamoxifen or aromatase inhibitors, gene expression analyses of 612 tumors was performed using the NanoString Breast Cancer 360 panel to interrogate 23 breast cancer pathways. Candidate signatures associated with disease subtype and event-free survival (EFS) were obtained by cluster analysis, Cox modeling, and conditional inference trees, and were independently tested in 613 patients from BreastMark. Tumor-infiltrating lymphocytes (TIL) were assessed on tissue sections, and mutational burden was assessed in 36 tumors by whole-exome sequencing. Results: PAM50-derived classification distinguished lower-risk (Luminal A) from higher-risk subtypes (Luminal B, P = 0.04; HER2, P = 0.006; Basal, P = 0.008). In higher-risk patients, shorter EFS was associated with low androgen receptor [HR = 3.61; 95% confidence interval (CI), 1.72–7.56; P = 0.001] or high BRCAness signature expression (HR = 3.58; 95% CI, 1.19–10.7; P = 0.023). BRCAness was independently confirmed as a predictor of shorter EFS (HR = 2.64; 95% CI, 1.31–5.34; P = 0.007). About 13%–15% of patients, enriched for high-grade, higher-risk subtypes (P ≤ 0.0001), had strong expression of the Tumor Inflammation Signature (TIS) suggestive of an inhibited antitumor immune response. TIS scores were strongly associated with TIL numbers (P &amp;lt; 1e-30) but not with tumor mutation status. Conclusions: BRCA-related DNA repair deficiency and suppressed tumor immune responses may be clinically relevant predictors of endocrine therapy complementing treatment options in subgroups of hormone-sensitive early breast cancer.
Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion
2020-10-02

Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT), the benefits of this dosage form could be utilized. Without any further measures, the probiotic bacteria will be eliminated too fast from the intended site of action, the oral mucosa. The use of mucoadhesive granules, composed of mucoadhesive polymer and probiotics, is a promising strategy to prolong the contact time between lactobacilli and oral mucosa without delaying disintegration. Three common mucoadhesive polymers, anionic Carbopol 971P NF, nonionic Metolose 65SH50 and cationic chitosan were included into tablets either by direct compression (DC) or after granulation with the probiotics. Disintegration, mucoadhesion of the tablets, and storage stability of the probiotics were characterized. By incorporating a sufficient amount of polymer superior probiotic mucoadhesion could be achieved. All formulations based on granulated probiotics and mucoadhesive polymer fulfilled the Food and Drug Administration (FDA) acceptance level for disintegration of orodispersible tablets. These formulations exhibited excellent storage stability under refrigerated conditions over 30 months. Interestingly, ODTs including Carbopol 971P NF still proved superior mucoadhesion after long-term storage, whereas the mucoadhesive effect of Metolose 65SH50 and chitosan declined markedly. The results of this study suggest that Carbopol 971P NF was the most appropriate polymer for a probiotic mucoadhesive ODT.
Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short Stature
2020-10-02

Assessment and management of children with growth failure has improved greatly over recent years. However, there remains a strong potential for further improvements by using novel digital techniques. A panel of experts discussed developments in digitalization of a number of important tools used by pediatric endocrinologists at the third 360° European Meeting on Growth and Endocrine Disorders, funded by Merck KGaA, Germany, and this review is based on those discussions. It was reported that electronic monitoring and new algorithms have been devised that are providing more sensitive referral for short stature. In addition, computer programs have improved ways in which diagnoses are coded for use by various groups including healthcare providers and government health systems. Innovative cranial imaging techniques have been devised that are considered safer than using gadolinium contrast agents and are also more sensitive and accurate. Deep-learning neural networks are changing the way that bone age and bone health are assessed, which are more objective than standard methodologies. Models for prediction of growth response to growth hormone (GH) treatment are being improved by applying novel artificial intelligence methods that can identify non-linear and linear factors that relate to response, providing more accurate predictions. Determination and interpretation of insulin-like growth factor-1 (IGF-1) levels are becoming more standardized and consistent, for evaluation across different patient groups, and computer-learning models indicate that baseline IGF-1 standard deviation score is among the most important indicators of GH therapy response. While physicians involved in child growth and treatment of disorders resulting in growth failure need to be aware of, and keep abreast of, these latest developments, treatment decisions and management should continue to be based on clinical decisions. New digital technologies and advancements in the field should be aimed at improving clinical decisions, making greater standardization of assessment and facilitating patient-centered approaches.
Understanding public sentiment about educational reforms: The Next Generation Science Standards on Twitter
2020-10-02

System-wide reform efforts in education in the United States are intrinsically challenging, and broad public support is likely to be a core component of their success. This study addresses the absence of any information on the degree of public support for the Next Generation Science Standards, a national science education reform effort. To do so, this study builds upon past research using social media data to estimate public sentiment for educational reforms with particular statistical (mixed effects models) and a number of data science (e.g., machine learning to detect user’s role as teachers) method. Using all posts on Twitter about the NGSS (N = 565,283), we found that the public sentiment towards the NGSS is overwhelmingly positive, with 11 negative posts for every 100 positive posts. Sentiment—especially teachers’—became more positive over time. These findings provide an indication that the NGSS may have some success as a system-wide reform.
Synthesis, Crystal Structure, and Luminescence of Metal Iodide Cluster Compounds (nBu4N)2[M6I8(NCO)6] with M = Mo, W
2020-10-02

Molybdenum and tungsten iodide clusters with the [M 6 I 8 ] cluster core show versatile photophysical properties that strongly depend on the nature of six apical ligands ( L ) in [M 6 I 8 L 6 ] 2– . In course of our syntheses we report a new efficient preparation of Cs 2 [Mo 6 I 14 ] as precursor. Target compounds ( n Bu 4 N) 2 [ M 6 I 8 (NCO) 6 ] with M = Mo, W with cyanate ligands were synthesized and structurally characterized to study their photophysical properties. ( n Bu 4 N) 2 [ M 6 I 8 (NCO) 6 ] compounds appear as deep red (Mo) and light yellow (W) crystal powders showing strong phosphorescence. Compared to other cluster compounds of this type there is no significant concentration quenching obtained by the presence of molecular oxygen.
Abstract neural choice signals during action-linked decisions
2020-10-02

Abstract Humans can make abstract choices independent of motor actions. However, in laboratory tasks, choices are typically reported with an associated action. Consequentially, knowledge about the neural representation of abstract choices is sparse, and choices are often thought to evolve as motor intentions. Here, we show that in the human brain, perceptual choices are represented in an abstract, motor-independent manner, even when they are directly linked to an action. We measured MEG signals while participants made choices with known or unknown motor response mapping. Using multivariate decoding, we quantified stimulus, perceptual choice and motor response information with distinct cortical distributions. Choice representations were invariant to whether the response mapping was known during stimulus presentation, and they occupied distinct representational spaces from both stimulus and motor signals. Furthermore, their strength predicted decision confidence and accuracy, as expected from an internal decision variable. Our results uncover abstract neural choice signals that generalize to action-linked decisions, suggesting a general role of an abstract choice stage in human decision-making.
Meningothelial meningioma of the oculomotor nerve: A case report and review of the literature
2020-10-02

Background: The origin of meningioma tumors is known as the meningothelial or arachnoid cap cells. The arachnoid granulations or villi are concentrated along with the dural venous sinuses in the cerebral convexity, parasagittally, and sphenoid wing regions. The majority of meningiomas are found in these locations with dural attachment. Infrequently, meningiomas develop without dural attachment but in dural adjacent. There are numerous reports of patients with cranial nerve involvement as a result of the compressive effect of the sinus cavernous or adjacent structures meningioma tumor on the cranial nerve. Case Description: In this study, we reviewed all reports of patients with third nerve involvement as a result of meningioma tumors in addition to the introduction of a new case. We present a 47-year-old woman presented with headache, diplopia, and ptosis. A gadolinium-enhanced mass on anterolateral of the left cerebral peduncle with no dural attachment was suggesting for Schwannoma at preoperative imaging. An adhesive 10 × 5 × 4 mm meningothelial meningioma arising from the oculomotor nerve was resected. Conclusion: The findings of this review suggest that there may be other mechanisms as the origin of meningiomas tumors. It is crucial to take into account origination mechanisms of meningioma using ectopic meningiomas due to the increasing prevalence of meningioma.
State-Dependent Gain Modulation of Spinal Motor Output
2020-10-02

Afferent somatosensory information plays a crucial role in modulating efferent motor output. A better understanding of this sensorimotor interplay may inform the design of neurorehabilitation interfaces. Current neurotechnological approaches that address motor restoration after trauma or stroke combine motor imagery (MI) and contingent somatosensory feedback, e.g., via peripheral stimulation, to induce corticospinal reorganization. These interventions may, however, change the motor output already at the spinal level dependent on alterations of the afferent input. Neuromuscular electrical stimulation (NMES) was combined with measurements of wrist deflection using a kinematic glove during either MI or rest. We investigated 360 NMES bursts to the right forearm of 12 healthy subjects at two frequencies (30 and 100 Hz) in random order. For each frequency, stimulation was assessed at nine intensities. Measuring the induced wrist deflection across different intensities allowed us to estimate the input-output curve (IOC) of the spinal motor output. MI decreased the slope of the IOC independent of the stimulation frequency. NMES with 100 Hz vs. 30 Hz decreased the threshold of the IOC. Human-machine interfaces for neurorehabilitation that combine MI and NMES need to consider bidirectional communication and may utilize the gain modulation of spinal circuitries by applying low-intensity, high-frequency stimulation.
Sustainable data analysis with Snakemake
2020-10-02

&amp;lt;p&amp;gt;Data analysis often entails a multitude of heterogeneous steps, from the application of various command line tools to the usage of scripting languages like R or Python for the generation of plots and tables. It is widely recognized that data analyses should ideally be conducted in a reproducible way. Reproducibility enables technical validation and regeneration of results on the original or even new data. However, reproducibility alone is by no means sufficient to deliver an analysis that is of lasting impact (i.e. sustainable) for the field, or even just one research group. We postulate that it is equally important to ensure adaptability and transparency.&amp;lt;br&amp;gt;\\nThe former describes the ability to modify the analysis to answer extended or slightly different research questions. The latter describes the ability to understand the analysis in order to judge whether it is not only technically, but methodologically valid.&amp;lt;/p&amp;gt;\\n\\n&amp;lt;p&amp;gt;Here, we analyze the properties needed for a data analysis to become reproducible, adaptable, and transparent, and show how the popular workflow management system Snakemake can be used to fulfill all these needs.&amp;lt;/p&amp;gt;