julilili42/papers huggingface dataset:
Compensatory Conscientiousness Redux
2016-08-02

The present study attempted to closely replicate Roberts, Smith, Jackson, and Edmonds (2009) who found, in part, a compensatory effect such that individuals with spouses higher in conscientiousness reported higher self-rated health and fewer physical limitations in the Health and Retirement Study. Using similarly structured data from the National Social Life, Health, and Aging Project ( N = 953), the current study found results largely consistent with the original study such that partner conscientiousness predicted both self-rated health and physical limitations, and husbands’ conscientiousness and neuroticism interacted when predicting wives’ self-rated health. A discussion of the usefulness of statistical significance versus effect size in replication follows.
Exercise therapy in patients with hip osteoarthritis: Effect on hip muscle strength and safety aspects of exercise—results of a randomized controlled trial
2016-08-03

The Tübingen exercise therapy approach has shown to have a significant positive effect on HMS. Its implementation has shown to be feasible and safe according to the percentage of exercise participation and the absence of sustainable adverse events.
DETECTION OF FORBIDDEN LINE COMPONENTS OF LITHIUM-LIKE CARBON IN STELLAR SPECTRA
2016-08-03

ABSTRACT We report the first identification of forbidden line components from an element heavier than helium in the spectrum of astrophysical plasmas. So far, these components were identified only in laboratory plasmas and not in astrophysical objects. Forbidden components are well known for neutral helium lines in hot stars, particularly in helium-rich post-AGB stars and white dwarfs. We discovered that two hitherto unidentified lines in the ultraviolet spectra of hot hydrogen-deficient (pre-) white dwarfs can be identified as forbidden line components of triply ionized carbon (C iv ). The forbidden components (3p–4f and 3d–4d) appear in the blue and red wings of the strong, Stark broadened 3p–4d and 3d–4f lines at 1108 Å and 1169 Å, respectively. They are visible over a wide effective temperature range (60,000–200,000 K) in helium-rich (DO) white dwarfs and PG 1159 stars that have strongly oversolar carbon abundances.
SEFE = C-Planarity?
2016-08-03

In this article, we deepen the understanding of the connection between two long-standing graph drawing open problems, Simultaneous Embedding with Fixed Edges (SEFE-2) and Clustered Planarity (C-Planarity). Given two planar graphs on the same set of vertices, the SEFE-2 problem asks to find planar drawings of the two graphs such that each vertex lies on the same point and each common edge is represented by the same curve in both drawings. Given a planar graph together with a recursive clustering of its vertices, the C-Planarity problem asks to find a planar drawing of the graph and a representation of each cluster as a simple region enclosing all and only the vertices of the cluster such that no unnecessary intersection involving clusters and edges is created. In a recent article at GD'12, Marcus Schaefer presented a reduction from C-Planarity to SEFE-2. We prove that a reduction exists also in the opposite direction, if we restrict to instances of SEFE-2 in which the graph induced by the common edges is connected. We pose as an intriguing open question whether the two problems are polynomial-time equivalent.
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans
2016-08-04

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly accumulated that insulin action in the brain produces multiple behavioral and metabolic effects, influencing eating behavior, peripheral metabolism, and cognition. Disturbances in brain insulin action can be observed in obesity and type 2 diabetes (T2D), as well as in aging and dementia. Decreases in insulin sensitivity of central nervous pathways, i.e., brain insulin resistance, may therefore constitute a joint pathological feature of metabolic and cognitive dysfunctions. Modern neuroimaging methods have provided new means of probing brain insulin action, revealing the influence of insulin on both global and regional brain function. In this review, we highlight recent findings on brain insulin action in humans and its impact on metabolism and cognition. Furthermore, we elaborate on the most prominent factors associated with brain insulin resistance, i.e., obesity, T2D, genes, maternal metabolism, normal aging, inflammation, and dementia, and on their roles regarding causes and consequences of brain insulin resistance. We also describe the beneficial effects of enhanced brain insulin signaling on human eating behavior and cognition and discuss potential applications in the treatment of metabolic and cognitive disorders.
High Frequency and Diversity of Antimicrobial Activities Produced by Nasal Staphylococcus Strains against Bacterial Competitors
2016-08-04

The human nasal microbiota is highly variable and dynamic often enclosing major pathogens such as Staphylococcus aureus. The potential roles of bacteriocins or other mechanisms allowing certain bacterial clones to prevail in this nutrient-poor habitat have hardly been studied. Of 89 nasal Staphylococcus isolates, unexpectedly, the vast majority (84%) was found to produce antimicrobial substances in particular under habitat-specific stress conditions, such as iron limitation or exposure to hydrogen peroxide. Activity spectra were generally narrow but highly variable with activities against certain nasal members of the Actinobacteria, Proteobacteria, Firmicutes, or several groups of bacteria. Staphylococcus species and many other Firmicutes were insusceptible to most of the compounds. A representative bacteriocin was identified as a nukacin-related peptide whose inactivation reduced the capacity of the producer Staphylococcus epidermidis IVK45 to limit growth of other nasal bacteria. Of note, the bacteriocin genes were found on mobile genetic elements exhibiting signs of extensive horizontal gene transfer and rearrangements. Thus, continuously evolving bacteriocins appear to govern bacterial competition in the human nose and specific bacteriocins may become important agents for eradication of notorious opportunistic pathogens from human microbiota.
Genomic validation of the differential preservation of population history in modern human cranial anatomy
2016-08-04

Abstract Objectives In modern humans, the significant correlation between neutral genetic loci and cranial anatomy suggests that the cranium preserves a population history signature. However, there is disagreement on whether certain parts of the cranium preserve this signature to a greater degree than other parts. It is also unclear how different quantitative measures of phenotype affect the association of genetic variation and anatomy. Here, we revisit these matters by testing the correlation of genetic distances and various phenotypic distances for ten modern human populations. Materials and Methods Geometric morphometric shape data from the crania of adult individuals ( n = 224) are used to calculate phenotypic P ST , Procrustes, and Mahalanobis distances. We calculate their correlation to neutral genetic distances, F ST , derived from single nucleotide polymorphisms (SNPs). We subset the cranial data into landmark configurations that include the neurocranium, the face, and the temporal bone in order to evaluate whether these cranial regions are differentially correlated to neutral genetic variation. Results Our results show that P ST , Mahalanobis, and Procrustes distances are correlated with F ST distances to varying degrees. They indicate that overall cranial shape is significantly correlated with neutral genetic variation. Of the component parts examined, P ST distances for both the temporal bone and the face have a stronger association with F ST distances than the neurocranium. When controlling for population divergence time, only the whole cranium and the temporal bone have a statistically significant association with F ST distances. Discussion Our results confirm that the cranium, as a whole, and the temporal bone can be used to reconstruct modern human population history.
Power‐ and polarization dependence of two photon luminescence of single CdSe nanowires with tightly focused cylindrical vector beams of ultrashort laser pulses
2016-08-04

Abstract We investigate two‐photon luminescence (TPL) of single CdSe nanowires (NWs) excited by tightly focused cylindrical vector beams of 150 fs pulses, achieving an optical resolution better than λ/4. Comparing the TPL images recorded by scanning the nanowires through the focal fields created either by a radially or an azimuthally polarized vector beam we observe a distinct anisotropic excitation efficiency which depends on the orientation of the electric field component with respect to the nanowire. The excitation anisotropy of the linear photoluminescence (PL) and TPL can directly be derived from the respective image patterns. Our results show that the highest TPL signal from a single NW is detected when the electric excitation field is parallel to the long axis of the NW, i.e. about one order of magnitude stronger than that excited along the short axis. We attribute the TPL to an emission mechanism based on the recombination of free carriers, which exhibits a fourth order excitation power dependence in low power regime and a second order power dependence in high power regime. image
Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
2016-08-04

Abstract Hepatocellular carcinoma (HCC) represents the second leading cause of cancer-related deaths and is reported to be resistant to chemotherapy caused by tumor-initiating cells. These tumor-initiating cells express stem cell markers. An accumulation of tumor-initiating cells can be found in 2% to 50% of all HCC and is correlated with a poor prognosis. Mechanisms that mediate chemoresistance include drug export, increased metabolism, and quiescence. Importantly, the mechanisms that regulate quiescence in tumor-initiating cells have not been analyzed in detail so far. In this research we have developed a single cell tracking method to follow up the fate of tumor-initiating cells during chemotherapy. Thereby, we were able to demonstrate that mCXCL1 exerts cellular state-specific effects regulating the resistance to chemotherapeutics. mCXCL1 is the mouse homolog of the human IL8, a chemokine that correlates with poor prognosis in HCC patients. We found that mCXCL1 blocks differentiation of premalignant cells and activates quiescence in tumor-initiating cells. This process depends on the activation of the mTORC1 kinase. Blocking of the mTORC1 kinase induces differentiation of tumor-initiating cells and allows their subsequent depletion using the chemotherapeutic drug doxorubicin. Our work deciphers the mCXCL1–mTORC1 pathway as crucial in liver cancer stem cell maintenance and highlights it as a novel target in combination with conventional chemotherapy. Cancer Res; 76(18); 5550–61. ©2016 AACR.
Characterization of the spontaneous light emission of the PMTs used in the Double Chooz experiment
2016-08-04

During the commissioning of the first of the two detectors of the Double Chooz experiment, an unexpected and dominant background caused by the emission of light inside the optical volume has been observed. A specific study of the ensemble of phenomena called Light Noise has been carried out in-situ, and in an external laboratory, in order to characterize the signals and to identify the possible processes underlying the effect. Some mechanisms of instrumental noise originating from the PMTs were identified and it has been found that the leading one arises from the light emission localized on the photomultiplier base and produced by the combined effect of heat and high voltage across the transparent epoxy resin covering the electric components. The correlation of the rate and the amplitude of the signal with the temperature has been observed. For the first detector in operation the induced background has been mitigated using online and offline analysis selections based on timing and light pattern of the signals, while a modification of the photomultiplier assembly has been implemented for the second detector in order to blacken the PMT bases.
Characterization of Vibrio cholerae Strains Isolated from the Nigerian Cholera Outbreak in 2010
2016-08-04

ABSTRACT We examined clinical samples from Nigerian patients with acute watery diarrhea for Vibrio cholerae during the 2010 cholera outbreak. A total of 109 suspected isolates were characterized, but only 57 V. cholerae strains could be confirmed using multiplex real-time PCR as well as rpoB sequencing and typed as V. cholerae O:1 Ogawa biotype El Tor. This finding highlighted the need for accurate diagnosis of cholera in epidemic countries to implement life-saving interventions.
Planet Formation Imager (PFI): science vision and key requirements
2016-08-04

The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to about 100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the "Hill Sphere" of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs.
Personalized Medicine Approaches in Parkinson’s Disease: The Genetic Perspective
2016-08-04

Recent discoveries with respect to the genetic and molecular basis of Parkinson’s disease have led to an increasing recognition of the etiologic heterogeneity of the disorder. As in other complex diseases, it is hoped that this knowledge will allow the identification of novel therapeutic targets that will eventually lead to a more efficient treatment, based on the patient’s individual genetic predispositions.
Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: a targeted proteomics approach
2016-08-05

The hepatokine FGF-21 exerts secretome-modulating effects in human perivascular (pre)adipocytes establishing a new liver-PVAT-blood vessel axis that possibly contributes to vascular inflammation and atherosclerosis.
Electronically Excited States of Borylenes
2016-08-05

Borylenes, RB, are elusive reactive intermediates. Still not much is known about their excited states from spectroscopic experiments, and existing knowledge is limited to diatomic borylenes only. The electronic structure and geometry of borylenes with diverse substituents on boron (where R = H, F, Cl, CH3, CF3, tBu, NH2, Ph, and SiMe3) were studied by means of computational chemistry. For this purpose, geometries of borylenes in their lowest singlet and triplet states were optimized at the B3LYP/def2-TZVP level of theory. Additionally, the influence of substitution on the energies of frontier molecular orbitals, HOMO-LUMO energy gaps, singlet-triplet energy splittings, and excitation energies was investigated. Two lowest vertical singlet-singlet excitations were computed using EOM-CCSD and TD-DFT (using hybrid B3LYP, and long-range separated CAM-B3LYP and ωB97X functionals) in combination with the aug-cc-pVTZ basis set. The electronic transitions involve excitations from nonbonding sp boron orbital (HOMO) mainly to empty p(B) orbitals and partially to the orbitals of the substituent, and are of n → π* type. The results can facilitate prospective identification of borylenes, e.g., in UV-vis matrix isolation or time-resolved spectroscopy experiments.
Yttrium Siloxide Complexes Bearing Terminal Methyl Ligands: Molecular Models for Ln−CH3 Terminated Silica Surfaces
2016-08-05

Abstract Surface organometallic chemistry (SOMC) on silica materials is a prominent approach for the generation of highly active heterogenized polymerization catalysts. Despite advanced methods of characterization, the elucidation of the catalytically active surface species remains a challenging task. Alkylated rare‐earth metal siloxide complexes can be regarded as molecular models of respective covalently bonded alkylated surface species, primarily used for 1,3‐diene polymerization. Here, we performed both salt metathesis reactions of [Y(MMe 4 ) 3 ] (M = Al, Ga) with [K{OSi(O t Bu) 3 }] and alkylation reactions of [Y{OSi(O t Bu) 3 } 3 ] 2 with AlMe 3 . The obtained complexes [Y(CH 3 )[(AlMe 2 ){OSi(O t Bu) 3 } 2 ](AlMe 4 )] 2 , [Y(CH 3 )[(AlMe 2 ){OSi(O t Bu) 3 } 2 ]‐{OSi(O t Bu) 3 }], [Y{OSi(O t Bu) 3 } 3 (μ‐Me)Y(μ‐Me) 2 Y{OSi(O t Bu) 3 } 2 (AlMe 4 )], and [Y(CH 3 )(GaMe 4 ){OSi(O t Bu) 3 }] 2 represent rare examples of organoyttrium species with terminal methyl groups. The formation and purity of the mixed methyl/siloxy yttrium complexes could be enhanced by treating [Y(MMe 4 ) 3 ] with [K(MMe 2 ){OSi(O t Bu) 3 } 2 ] n (M=Al: n =2; M=Ga: n =∞). Complexes [K(MMe 2 ){OSi(O t Bu) 3 } 2 ] n were obtained by addition of [K{OSi(O t Bu) 3 }] to [Me 2 M{OSi(O t Bu) 3 }] 2 . Deeper insight into the fluxional behavior of the mixed methyl/siloxy yttrium complexes in solution was gained by 1 H and 13 C NMR spectroscopic studies at variable temperature and 1 H– 89 Y HSQC NMR spectroscopy.
Prevalence and distribution pattern of nodal metastases in advanced ovarian cancer
2016-08-05

The objective of this study was to examine the relevance of pelvic and para-aortic lymph node involvement and the tumour characteristics affecting nodal metastases and survival in primary advanced ovarian cancer. A total of 130 consecutive patients were retrospectively investigated. All the patients received stage-related surgery with pelvic and para-aortic lymphadenectomy. The median follow-up was 53.5 months. The clinicopathological parameters and distribution pattern of nodal metastases were evaluated. Lymph node metastases were detectable in 74.62% of the cases. Overall, both pelvic and para-aortic nodes were affected in 35.9% of the patients, whereas 13.3% had metastases only in the pelvic and 13.3% only in the para-aortic lymph nodes. Histological grade 1/2 and 3, serous and endometrioid histology were independent predictors of nodal metastasis. Serous and endometrioid cancers have shown a predilection for metastasis to the pelvic lymph nodes alone, both to the pelvic and the para-aortic nodes, or the para-aortic nodes alone. Overall survival was significantly positively affected by serous histology with positive nodes (P=0.043). It is crucial to investigate the risk factors and metastatic patterns of such patients in a multicenter analysis to evaluate individual subgroups. Prospective studies are required to investigate the prognostic effect of lymphadenectomy in advanced ovarian cancer and its association with histology and distribution pattern of nodal metastasis.
Smartphone addiction proneness in relation to sleep and morningness–eveningness in German adolescents
2016-08-06

Background Mobile phones are an important part of adolescents’ life. In this study, the relationships among smartphone addiction, age, gender, and chronotype of German adolescents were examined. Materials and methods Two studies focused on two different measures of smartphone addiction. The Smartphone Addiction Proneness Scale ( SAPS ) was applied to 342 younger adolescents (13.39 ± 1.77; 176 boys, 165 girls, and 1 not indicated) in Study 1 and the Smartphone Addiction Scale was applied to 208 older adolescents (17.07 ± 4.28; 146 girls and 62 boys) in Study 2, both samples in southwest Germany. In addition, a demographic questionnaire and the Composite Scale of Morningness ( CSM ) and sleep measures were implemented. Results The most remarkable result of this study was that morningness–eveningness (as measured by CSM scores) is an important predictor for smartphone addiction; even stronger than sleep duration. Evening oriented adolescents scored higher on both smartphone addiction scales. In addition, gender is an important predictor for smartphone addiction and girls are more prone to become addicted. In addition, while sleep duration on weekdays negatively predicted SAPS, age, sleep duration on weekends, and midpoint of sleep on weekdays and weekends did not predicted smartphone addiction in both scales. The analysis of covariance revealed statistically significant effects of the covariates gender and age in both studies, as well as the main effect of chronotype. According to the t -test results, girls had higher scores than boys in smartphone addiction. Conclusion Evening types and girls are more prone to become smartphone addicted.
The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling
2016-08-06

ABSTRACT The spatial regulation of cellular Rho signaling by GAP proteins is still poorly understood. By performing mass spectrometry, we here identify the polarity protein Scribble as a scaffold for the RhoGAP protein DLC3 (also known as StarD8) at cell–cell adhesions. This mutually dependent interaction is mediated by the PDZ domains of Scribble and a PDZ ligand (PDZL) motif in DLC3. Both Scribble depletion and PDZL deletion abrogated DLC3 junctional localization. Using a RhoA biosensor and a targeted GAP domain, we demonstrate that DLC3 activity locally regulates RhoA–ROCK signaling at and Scribble localization to adherens junctions, and is required for their functional integrity. In a 3D model of cyst development, we furthermore show that DLC3 depletion impairs polarized morphogenesis, phenocopying the effects observed upon Scribble knockdown. We thus propose a new function for Scribble in Rho regulation that entails positioning of DLC3 GAP activity at cell junctions in polarized epithelial cells.
Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene
2016-08-06

Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor PDX1 leads to pancreatic agenesis, whereas certain heterozygous point mutations are associated with Maturity-Onset Diabetes of the Young 4 (MODY4) and Type 2 Diabetes Mellitus (T2DM). To understand the pathomechanism of MODY4 and T2DM, we have generated iPSCs from a woman with a P33T heterozygous mutation in the transactivation domain of PDX1. The resulting PDX1 P33T iPSCs generated by episomal reprogramming are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Taken together, this iPSC line will be useful to study diabetes pathomechanisms.