julilili42/papers huggingface dataset:
Not anxious enough: The discursive articulation of ontological security in the European Parliament
2024-11-11

Abstract This paper makes the case for a discursive understanding of ontological security and demonstrates the utility of such an approach in an analysis of European Parliament (EP) debates between 1990 and 2020. We argue that articulations of ontological (in)security operate through the (re)inscription of a set of metanarratives in what we call ‘discursive nodal points’. Building on an extensive analysis of EP debates over 30 years, we demonstrate that in contrast to the prevailing view of the European Union (EU) as an ‘anxious community’, at least on the political level, EU actors remain surprisingly confident in the European project. While they do invoke challenges to the EU, they see these as incentives to strengthen the integration project and often consider operating in crisis mode as an essential EU characteristic. In doing so, they draw on modernist metanarratives of progress, control, and power to construct an ontologically secure EU. We argue that the future ontological security of the EU will partly depend on allowing for more ambiguity in this modernist narrative without accepting a nationalist counter-narrative that undermines the idea of European integration.
Risking your Tail: Modeling Individual Differences in Risk-sensitive Exploration using Bayes Adaptive Markov Decision Processes
2024-11-11

Abstract Novelty is a double-edged sword for agents and animals alike: they might benefit from untapped resources or face unexpected costs or dangers such as predation. The conventional exploration/exploitation tradeoff is thus coloured by risk-sensitivity. A wealth of experiments has shown how animals solve this dilemma, for example using intermittent approach. However, there are large individual differences in the nature of approach, and modeling has yet to elucidate how this might be based on animals’ differing prior expectations about reward and threat, and differing degrees of risk aversion. To capture these factors, we built a Bayes adaptive Markov decision process model with three key components: an adaptive hazard function capturing potential predation, an intrinsic reward function providing the urge to explore, and a conditional value at risk (CVaR) objective, which is a contemporary measure of trait risk-sensitivity. We fit this model to a coarse-grain abstraction of the behaviour of 26 animals who freely explored a novel object in an open-field arena (Akiti et al. Neuron 110, 2022). We show that the model captures both quantitative (frequency, duration of exploratory bouts) and qualitative (stereotyped tail-behind) features of behavior, including the substantial idiosyncrasies that were observed. We find that “brave” animals, though varied in their behavior, are generally more risk neutral, and enjoy a flexible hazard prior. They begin with cautious exploration, and quickly transition to confident approach to maximize exploration for reward. On the other hand, “timid” animals, characterized by risk aversion and high and inflexible hazard priors, display self-censoring that leads to the sort of asymptotic maladaptive behavior that is often associated with psychiatric illnesses such as anxiety and depression. Explaining risk-sensitive exploration using factorized parameters of reinforcement learning models could aid in the understanding, diagnosis, and treatment of psychiatric abnormalities in humans and other animals.
Risking your Tail: Modeling Individual Differences in Risk-sensitive Exploration using Bayes Adaptive Markov Decision Processes
2024-11-11

Abstract Novelty is a double-edged sword for agents and animals alike: they might benefit from untapped resources or face unexpected costs or dangers such as predation. The conventional exploration/exploitation tradeoff is thus coloured by risk-sensitivity. A wealth of experiments has shown how animals solve this dilemma, for example using intermittent approach. However, there are large individual differences in the nature of approach, and modeling has yet to elucidate how this might be based on animals’ differing prior expectations about reward and threat, and differing degrees of risk aversion. To capture these factors, we built a Bayes adaptive Markov decision process model with three key components: an adaptive hazard function capturing potential predation, an intrinsic reward function providing the urge to explore, and a conditional value at risk (CVaR) objective, which is a contemporary measure of trait risk-sensitivity. We fit this model to a coarse-grain abstraction of the behaviour of 26 animals who freely explored a novel object in an open-field arena (Akiti et al. Neuron 110, 2022). We show that the model captures both quantitative (frequency, duration of exploratory bouts) and qualitative (with distinguished, cautious, tail-behind approach) features of behavior, including the substantial idiosyncrasies that were observed. Some animals begin with cautious exploration, and quickly transition to confident approach to maximize exploration for reward; we classify them as potentially more risk neutral, and enjoying a flexible hazard prior. By contrast, other animals only ever approach in a cautious manner and display a form of self-censoring; they are characterized by potential risk aversion and high and inflexible hazard priors. Explaining risk-sensitive exploration using factorized parameters of reinforcement learning models could aid in the understanding, diagnosis, and treatment of psychiatric abnormalities such as anxiety disorders.
A new series of corpus presentations
2024-11-11

The Journal of Language and Aging Research (JLAR) presents a new series of corpus presentations. The series is meant to feature research data suitable for analyzing the processes and manifestations of linguistic aging. Dedicated to the idea of open science, data are presented with regard to the principles of findability, availability, interoperability, and reusability (FAIR). Limitations of open access due to ethical concerns and possible other limitations are discussed. The series of corpus presentations allows for a standardized introduction of newly conceived or established datasets, promotes the exchange, on an empirical basis, of Language and Aging Research (LAR), stimulates the discussion of standards in Research Data Management (RDM), and motivates the further development and sharing of resources and techniques within the community. Faced with age-related bias in artificial intelligence and with copyright issues, settling the provenance of datasets representing older adults and guaranteeing their originality holds immense significance.
Neural correlates of sensorimotor adaptation: Thalamic contributions to learning from sensory prediction error
2024-11-12

Understanding the neural mechanism of sensorimotor adaptation is essential to reveal how the brain learns from errors, a process driven by sensory prediction errors. While the previous literature has focused on cortical and cerebellar changes, the involvement of the thalamus has received less attention. This functional magnetic resonance imaging study aims to explore the neural substrates of learning from sensory prediction errors with an additional focus on the thalamus. Thirty participants adapted their goal-directed reaches to visual feedback rotations introduced in a step-wise manner, while reporting their predicted visual consequences of their movements intermittently. We found that adaptation initially engaged the cerebellum and fronto-parietal cortical regions, which persisted as adaptation progressed. By the end of adaptation, additional regions within the fronto-parietal cortex and medial pulvinar of the thalamus were recruited. Another finding was the involvement of bilateral medial dorsal nuclei, which showed a positive correlation with the level of motor adaptation. Notably, the gradual shift in the predicted hand movement consequences was associated with activity in the cerebellum, motor cortex and thalamus (ventral lateral, medial dorsal, and medial pulvinar). Our study presents clear evidence for an involvement of the thalamus, both classical 'motor' and higher-order nuclei, in error-based motor learning.
Mevalonate kinase deficiency: an updated clinical overview and revision of the SHARE recommendations
2024-11-12

Mevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the MVK gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive review provides an updated perspective on MKD, including its aetiology, pathogenesis, diagnostic modalities, and therapeutic strategies. Based on recent research and clinical advances, our objective is to bridge the knowledge gaps in the 2015 SHARE guidelines. By describing molecular mechanisms, diagnostic dilemmas, and emerging therapies, this article should serve as a resource for clinicians and researchers, promoting a deeper understanding of MKD and guiding optimal patient care.
Hemin promotes platelet activation and plasma membrane disintegration regulated by the subtilisin‐like proprotein convertase furin
2024-11-12

Abstract Platelet activation plays a critical role in thrombosis and hemostasis. Several pathophysiological situations lead to hemolysis, resulting in the liberation of free ferric iron‐containing hemin. Hemin has been shown to activate platelets and induce thrombo‐inflammation. Classical antiplatelet therapy failed to prevent hemin‐induced platelet activation. Thus, the aim of the present study was to characterize the mechanism of hemin‐induced platelet death (ferroptosis). We evaluated the in vitro effect of hemin on platelet activation, signaling, oxylipins, and plasma membrane destruction using light transmission aggregometry, ex vivo thrombus formation, multiparametric flow cytometry, micro‐UHPLC mass spectrometry for oxylipin profiling, and scanning ion conductance microscopy (SICM). We found that hemin induces platelet cell death indicated by increased ROS levels, phosphatidyl serine (PS) exposure, and loss of mitochondrial membrane potential (ΔΨm). Further, hemin causes lipid peroxidation and generation of distinct oxylipins, which strongly affects plasma membrane integrity leading to generation of platelet‐derived microvesicles. Interestingly, hemin‐dependent platelet death (ferroptosis) is specifically regulated by the subtilisin‐like proprotein convertase furin. In summary, platelet undergo a non‐apoptotic cell death mediated by furin. Inhibition of furin may offer a therapeutic strategy to control hemin‐induced thrombosis and thrombo‐inflammation at a site of hemolysis.
Walking the Line: Young Stars on the Boundary of the Epsilon Cha and Lower Centaurus Crux Associations
2024-11-12

Abstract Gaia Data Release 3 (DR3) has provided the largest and most astrometrically precise catalog of nearby stars to date, allowing for a more complete membership census of nearby, young stellar moving groups. These loose associations of young (age &lt;100 Myr) stars within ∼100 pc are vital laboratories for the study of the early evolution of low-mass stars and planetary systems. We have exploited DR3 data to examine the boundary region between two of the youngest nearby moving groups, the ∼3–8 Myr-old ε Cha Association (ECA) and an ∼8 Myr-old subpopulation of the sprawling Lower Centaurus Crux (LCC) young star complex. Using spatiokinematic and color–magnitude criteria designed to select stars in the ECA, we identify ∼54 new young-star candidates that extend from the ECA core to the southern edge of the LCC. Included among our new candidates are six previously unidentified ultra-low-mass, mid- to late-M stars, lying near the future hydrogen-burning limit, which display significant infrared excesses. Our spatial, kinematic, and CMD analysis of these new candidates and previously established LCC and ECA members blurs the boundary between these groups and provides evidence for a wave of continuous star formation extending from north (LCC) to south (ECA). We discuss the factors which studies of nearby young moving groups must consider when constraining the ages of stars in these groups.
Differences in species composition between calcareous and siliceous herbaceous communities are primarily explained by competition in favourable climates
2024-11-12

Difference in vegetation composition between communities from calcareous and siliceous soils might be due to high competition on siliceous soils for species from calcareous origin, and high rock‐induced drought stress on calcareous soils for species from siliceous origin. We tested the hypothesis that, with increasing climate stress, competition should decrease on siliceous rock for species of calcareous origin and drought stress increase on calcareous rock for species of siliceous origin because of decreasing community biomass with increasing cold or drought stress. This question is of high interest for predicting changes in species distribution with climate change since bedrock type and climate change are both complex factors that are likely to interact with climate. We set up a transplant removal experiment in contrasting climate conditions of the south of France, warm and wet temperate, warm and dry Mediterranean, and cold temperate in the Alps and the Pyrenees. In each climate condition, three targets (two species and one population from a third species) from each origin were transplanted with and without neighbours on the two rock types and during two years with different levels of drought stress. Variation in the effects of neighbours and rock‐induced drought stress on transplant survival with and without neighbours were analysed with linear modelling at each site, separately, and with ANCOVA in the whole design. Competition was the highest on siliceous rock in the more favourable climate conditions but for species of siliceous origin. The lower competition found for species of calcareous origin was likely due to the occurrence of allelopathic effects that decreased the negative effect of neighbours as measured with the removal method. The rock‐induced drought stress was the highest on calcareous rock, in particular for species of siliceous origin. Thus, the decrease in competition intensity on siliceous rocks with increasing climate stress was more important for species from siliceous than calcareous origin. Additionally, the importance of the rock‐induced drought stress was relatively low in the most stressful climate conditions as compared to the overwhelming importance of climate drought stress over the two years of our experiment, which likely induced a collapse of the positive effect of growing on a siliceous rock.
Multidimensional gender ideologies: How do they relate to work-family arrangements of mothers with dependent children in Poland and western Germany?
2024-11-12

This study uses a multidimensional approach to identify gender ideologies and investigate their association with work-family arrangements among mothers of dependent children in Poland and western Germany. Based on data from the Generations and Gender Survey, we apply ordinal latent class analysis and identify five gender ideology classes: (1) traditional, (2) intensive parenting, (3) ambivalent, (4) moderately egalitarian, and (5) strongly egalitarian. In both countries, we find that the intensive parenting class resembles the traditional class in terms of lower maternal employment, a more gendered division of housework and childcare, and a smaller probability of using formal childcare, whereas the ambivalent respondents mostly practice work-care arrangements that are similar to the moderately egalitarian class. With respect to informal care, mothers who identify with strong egalitarianism significantly differ from the traditional class in western Germany, but they do not in Poland—thus highlighting the role of the cultural and institutional context in explaining the complex links between mothers’ gender ideologies and work-family arrangements.
XMM‐Newton Observations of the Peculiar Be X‐Ray Binary A0538‐66
2024-11-12

ABSTRACT A0538‐66 is a neutron star/Be x‐ray binary located in the Large Magellanic Cloud and, since its discovery in the 70s, it showed a peculiar behavior that makes it a unique object in the high‐mass x‐ray binaries scene: the extremely eccentric orbit (), the short spin period of the neutron star ( ms), the episodes of super‐Eddington accretion. These characteristics contribute to a remarkable bursting activity that lasts from minutes to hours and increases the flux by a factor . In 2018, A0538‐66 was observed by XMM‐Newton in a particularly active state, characterized by a forest of short bursts lasting s each. In this contribution, we present a reanalysis of these observations. The timing analysis allowed us to distinguish between the epochs of direct accretion and propeller state that do not correlate with the orbital position of the neutron star. The spectral analysis revealed that during the accretion regime, three components (a soft one, a hard one, and a ‐keV emission line) equally contribute to the overall emission, while the propeller regime is characterized by a single soft component. We discuss these findings in the context of spherical and disk accretion regimes, highlighting the similarities and differences with other x‐ray binary systems.
Abstract 4136692: Spatial Transcriptomics Identifies Novel Clinical Markers to Classify the Etiology of Rare and Aggressive Cardiac Sarcomas
2024-11-12

Background: Cardiac sarcomas, such as leiomyosarcoma (LMS), synovial sarcoma (SS), and undifferentiated pleomorphic sarcoma (UPS), lack sufficient diagnostic markers for early diagnosis and tailored therapeutic interventions. Understanding their molecular signatures with spatial-temporal resolution compared to normal heart tissue is crucial. Hypothesis: Spatial transcriptomics will reveal a comprehensive set of novel clinical markers, including changes in cellular composition, stemness, and metabolic profiles unique for each cardiac sarcoma subtypes. Aims: Identify novel molecular markers for the accurate diagnosis of cardiac sarcoma subtypes. Methods: Using 10X Visium spatial transcriptomics, we analyzed three cardiac sarcoma subtypes (LMS, SS, UPS) and compared them with normal heart tissue. Differential expression analysis identified novel target genes suitable for clinical disease stratification. Subsequently, machine learning models reveal an unbiased transcriptomic profile to distinguish normal from sarcoma tissues. Finally, immunohistochemistry analysis validated the differential marker gene expression. Results: We identify several novel clinical markers, such as IGKC, PCOLCE, NET1, TLE2, MDFI, BGN, TNNC1, and CNN3, that classify normal heart tissue from sarcoma subtypes. Machine learning models and immunostaining analysis confirm the transcriptomic signature in each sarcoma subtype. Pathway enrichment analysis show LMS enriched in antigen processing and B cell-mediated immunity, SS in protein folding and response to incorrect proteins, and UPS in axon development and Wnt signaling regulation. Trajectory Reconstruction Analysis indicate higher stemness scores in all sarcomas, with SS highest, followed by UPS and LMS. Additional cell cycling analysis show LMS cells in G2M phase, SS in G1, and UPS in S phase. SS express a high number of cancer stem markers (EZH2, BMI1, KDM5B, LGR5, HIF1A), while UPS express KDM5B and CTNNB1, and LMS show fewer stem-related marker genes (EZH2, BMI1, KDM5B, CTNNB1). Both SS and LMS express CD44. Glucose and oxidative pathways are also differentially regulated in each sarcoma subtype. Conclusion: Spatial transcriptomics uncovers distinct clinical markers, stemness characteristics, and metabolic activity profiles in cardiac sarcomas, offering insights for fast, accurate and improved diagnostics and therapeutics.
Realizability of tropical pluri‐canonical divisors
2024-11-12

Abstract Consider a pair consisting of an abstract tropical curve and an effective divisor from the linear system associated to times the canonical divisor for . In this article, we give a purely combinatorial criterion to determine if such a pair arises as the tropicalization of a pair consisting of a smooth algebraic curve over a non‐Archimedean field with algebraically closed residue field of characteristic 0 together with an effective pluri‐canonical divisor. To do so, we introduce tropical normalized covers as special instances of cyclic tropical Hurwitz covers and reduce the realizability problem for pluri‐canonical divisors to the realizability problem for normalized covers. Our main result generalizes the work of Möller–Ulirsch–Werner on realizability of tropical canonical divisors and incorporates the recent progress on compactifications of strata of ‐differentials in the work of Bainbridge–Chen–Gendron–Grushevsky–Möller.
Who Is Afraid of …? A Spell Against the Evil Eye (pBM EA10563)
2024-11-12

The fear of the evil eye is common throughout the world and found in many cultures. Interestingly, there are only a few examples known from ancient Egypt, even if sources such as the Temple Library of Edfu state that there existed rituals against the evil eye. The following article presents papyrus BM EA10563, which contains a new spell against the evil eye, before all known attestations are presented in chronological order and discussed. [Formula: see text]
Post-criticality and the pursuit of an empirical philosophy of education: epistemology, methodology, ethics
2024-11-12

Abstract This article examines the relevance of post-criticality as a research stance across various traditions in educational research. After problematizing the dominance of critical approaches centred on deconstruction and denunciation, the authors advocate instead for an empirical philosophy of education. This article sets the stage for a suite of articles, published in this issue, which explore affirmative, engaged methodologies that prioritize proximity to educational practices over detached critique. Collectively, the articles investigate how post-critical methodologies can produce richer understandings of educational realities and foster meaningful connections between theory and practice.