julilili42/papers huggingface dataset:
Experimental investigation of the impact of compound‐specific dispersion and electrostatic interactions on transient transport and solute breakthrough
2017-01-13

Abstract This study investigates the effects of compound‐specific diffusion/dispersion and electrochemical migration on transient solute transport in saturated porous media. We conducted laboratory bench‐scale experiments, under advection‐dominated regimes (seepage velocity: 0.5, 5, 25 m/d), in a quasi two‐dimensional flow‐through setup using pulse injection of multiple tracers (both uncharged and ionic species). Extensive sampling and measurement of solutes' concentrations (∼1500 samples; &gt;3000 measurements) were performed at the outlet of the flow‐through setup, at high spatial and temporal resolution. The experimental results show that compound‐specific effects and charge‐induced Coulombic interactions are important not only at low velocities and/or for steady state plumes but also for transient transport under high flow velocities. Such effects can lead to a remarkably different behavior of measured breakthrough curves also at very high Péclet numbers. To quantitatively interpret the experimental results, we used four modeling approaches: classical advection‐dispersion equation (ADE), continuous time random walk (CTRW), dual‐domain mass transfer model (DDMT), and a multicomponent ionic dispersion model. The latter is based on the multicomponent formulation of coupled diffusive/dispersive fluxes and was used to describe and explain the electrostatic effects of charged species. Furthermore, we determined experimentally the temporal profiles of the flux‐related dilution index. This metric of mixing, used in connection with the traditional solute breakthrough curves, proved to be useful to correctly distinguish between plume spreading and mixing, particularly for the cases in which the sole analysis of integrated concentration breakthrough curves may lead to erroneous interpretation of plume dilution.
Crossed cerebellar diaschisis in acute ischemic stroke: Impact on morphologic and functional outcome
2017-01-13

Crossed cerebellar diaschisis (CCD) is the phenomenon of hypoperfusion and hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the related supratentorial region. Our aim was to analyze its influence on morphologic and functional outcome in acute ischemic stroke. Subjects with stroke caused by a large vessel occlusion of the anterior circulation were selected from an initial cohort of 1644 consecutive patients who underwent multiparametric CT including whole-brain CT perfusion. Two experienced readers evaluated the posterior fossa in terms of CCD absence (CCD−) or presence (CCD+). A total of 156 patients formed the study cohort with 102 patients (65.4%) categorized as CCD− and 54 (34.6%) as CCD+. In linear and logistic regression analyses, no significant association between CCD and final infarction volume (β = −0.440, p = 0.972), discharge mRS ≤ 2 (OR = 1.897, p = 0.320), or 90-day mRS ≤ 2 (OR = 0.531, p = 0.492) was detected. CCD+ patients had larger supratentorial cerebral blood flow deficits (median: 164 ml vs. 115 ml; p = 0.001) compared to CCD−patients. Regarding complications, CCD was associated with a higher rate of parenchymal hematomas (OR = 4.793, p = 0.035). In conclusion, CCD is frequently encountered in acute ischemic stroke caused by large vessel occlusion of the anterior circulation. CCD was associated with the occurrence of parenchymal hematoma in the ipsilateral cerebral infarction but did not prove to significantly influence patient outcome.
The remarkable outburst of the highly-evolved post period-minimum dwarf nova SSS J122221.7−311525
2017-01-13

We report extensive 3-yr multiwavelength observations of the WZ Sge-type dwarf nova SSS J122221.7−311525 during its unusual double superoutburst, the following decline and in quiescence. The second segment of the superoutburst had a long duration of 33 d and a very gentle decline with a rate of 0.02 mag d−1, and it displayed an extended post-outburst decline lasting at least 500 d. Simultaneously with the start of the rapid fading from the superoutburst plateau, the system showed the appearance of a strong near-infrared excess resulting in very red colours, which reached extreme values (B − I ≃ 1.4) about 20 d later. The colours then became bluer again, but it took at least 250 d to acquire a stable level. Superhumps were clearly visible in the light curve from our very first time-resolved observations until at least 420 d after the rapid fading from the superoutburst. The spectroscopic and photometric data revealed an orbital period of 109.80 min and a fractional superhump period excess ≲0.8 per cent, indicating a very low mass ratio q ≲ 0.045. With such a small mass ratio the donor mass should be below the hydrogen-burning minimum mass limit. The observed infrared flux in quiescence is indeed much lower than is expected from a cataclysmic variable with a near-main-sequence donor star. This strongly suggests a brown-dwarf-like nature for the donor and that SSS J122221.7−311525 has already evolved away from the period minimum towards longer periods, with the donor now extremely dim.
Impact of transjugular intrahepatic portosystemic shunt implantation on liver perfusion measured by volume perfusion CT
2017-01-13

Background Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) induces changes of liver perfusion. Purpose To determine the changes in arterial, portal venous, and total perfusion of the liver parenchyma induced by TIPS using the technique of volume perfusion computed tomography (VPCT) and compare results with invasively measured hepatic intravascular pressure values. Material and Methods VPCT quantification of liver perfusion was performed in 23 patients (mean age, 62.5 ± 8.8 years) with portal hypertension in the pre-TIPS and post-TIPS setting, respectively. A commercially available software package was used for post-processing, enabling separate calculation of the dual (arterial [ALP] and portal venous [PVP]) blood supply and additionally of the hepatic perfusion index (HPI) (HPI = ALP/(ALP + PVP)*100%). Invasive pressure measurements were performed during the intervention, before and after TIPS placement. Liver function tests performed before and after the procedure were compared. Results Mean decrease of pressure gradient through TIPS was 13.3 mmHg. Mean normal values for ALP, PVP, and total perfusion (ALP + PVP) before TIPS were 15.9, 37.7, and 53.5 mL/100 mL/min, respectively, mean HPI was 35.4%. After TIPS, ALP increased to a mean value of 37.7 mL/100 mL/min, PVP decreased (15.7 mL/100 mL/min, P &lt; 0.05), whereas total perfusion remained unchanged (53.4 mL/100 mL/min, P = 0.97). HPI increased (71.9%; P &lt; 0.05). No correlation between invasive pressure measurement and VPCT parameters was observed. After TIPS, liver function tests were found to worsen with a significant increase of bilirubin ( P &lt; 0.05). Conclusion Following TIPS placement, ALP and HPI increased in all patients, whereas PVP markedly decreased. Interestingly, the magnitude of decrease in portosystemic pressure gradients was not found to correlate with VPCT parameters.
Possible regular phenomena in EXO 2030+375
2017-01-13

\\n In the last 10 yr, since its last giant outburst in 2006, regular X-ray outbursts (type I) were detected every periastron passage in the Be X-ray binary EXO 2030+375. Recently, however, it was reported that the source started to show a peculiar behavior: its X-ray flux decreased significantly and type I outbursts were missed in several cases. At the same time, the spin frequency of the neutron star, which had been increasing steadily since the end of the 2006 giant outburst, reached a plateau. Very recent observations indicate that the source is now starting to spin down. These observed phenomena have a striking similarity with those which took place 21 yr ago, just before the source displayed a sudden orbital phase shift of the outburst peak (1995). This historical event occurred at the time exactly between the two giant outbursts (1985 and 2006). These phenomena suggest the system to have an underlying periodicity of 10.5 yr between orbital phase shifts and/or giant outbursts. The suggested periodicity may reflect some long-period dynamics in the circumstellar disk of the Be star, due, e.g., to the Kozai-Lidov effect. A model generating such a periodic change of the Be disk, namely Kozai-Lidov oscillations in the Be disk, is discussed. If this behavior is really periodical, another phase shift of the X-ray outburst peak is predicted to occur around 2016 December.\\n
Feasibility of low-dose digital pulsed video-fluoroscopic swallow exams (VFSE): effects on radiation dose and image quality
2017-01-13

Background Fluoroscopy is a frequently used examination in clinical routine without appropriate research evaluation latest hardware and software equipment. Purpose To evaluate the feasibility of low-dose pulsed video-fluoroscopic swallowing exams (pVFSE) to reduce dose exposure in patients with swallowing disorders compared to high-resolution radiograph examinations (hrVFSE) serving as standard of reference. Material and Methods A phantom study (Alderson-Rando Phantom, 60 thermoluminescent dosimeters [TLD]) was performed for dose measurements. Acquisition parameters were as follows: (i) pVFSE: 76.7 kV, 57 mA, 0.9 Cu mm, pulse rate/s 30; (ii) hrVFSE: 68.0 kV, 362 mA, 0.2 Cu mm, pictures 30/s. The dose area product (DAP) indicated by the detector system and the radiation dose derived from the TLD measurements were analyzed. In a patient study, image quality was assessed qualitatively (5-point Likert scale, 5 = hrVFSE; two independent readers) and quantitatively (SNR) in 35 patients who subsequently underwent contrast-enhanced pVFSE and hrVFSE. Results Phantom measurements showed a dose reduction per picture of factor 25 for pVFSE versus hrVFSE images (0.0025 mGy versus 0.062 mGy). The DAP (μGym 2 ) was 28.0 versus 810.5 (pVFSE versus hrVFSE) for an average examination time of 30 s. Direct and scattered organ doses were significantly lower for pVFSE as compared to hrVFSE ( P &lt; 0.05). Image quality was rated 3.9 ± 0.5 for pVFSE versus the hrVFSE standard; depiction of the contrast agent 4.8 ± 0.3; noise 3.6 ± 0.5 ( P &lt; 0.05); SNR calculations revealed a relative decreased of 43.9% for pVFSE as compared to hrVFSE. Conclusion Pulsed VFSE is feasible, providing diagnostic image quality at a significant dose reduction as compared to hrVFSE.
Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing—G/C Substitution Stabilizes GuideRNAs against Editing
2017-01-14

Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1, in both isoforms, p110 and p150. However, further optimization seems necessary as the current design is less efficient for ADAR1 isoforms. Furthermore, we describe hotspots at which the guideRNA itself is edited and show a way to circumvent this auto-editing without losing editing efficiency at the target. Both findings are important for the advancement of site-directed RNA editing as a tool in basic biology or as a platform for therapeutic editing.
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
2017-01-15

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a paracrine manner. However, the SASP has also been shown to favor embryonic development, wound healing, and even tumor growth, suggesting more complex physiological roles than currently understood. Here we uncover timely new functions of the SASP in promoting a proregenerative response through the induction of cell plasticity and stemness. We show that primary mouse keratinocytes transiently exposed to the SASP exhibit increased expression of stem cell markers and regenerative capacity in vivo. However, prolonged exposure to the SASP causes a subsequent cell-intrinsic senescence arrest to counter the continued regenerative stimuli. Finally, by inducing senescence in single cells in vivo in the liver, we demonstrate that this activates tissue-specific expression of stem cell markers. Together, this work uncovers a primary and beneficial role for the SASP in promoting cell plasticity and tissue regeneration and introduces the concept that transient therapeutic delivery of senescent cells could be harnessed to drive tissue regeneration.
Limiting parental feedback disrupts vocal development in marmoset monkeys
2017-01-16

Abstract Vocalizations of human infants undergo dramatic changes across the first year by becoming increasingly mature and speech-like. Human vocal development is partially dependent on learning by imitation through social feedback between infants and caregivers. Recent studies revealed similar developmental processes being influenced by parental feedback in marmoset monkeys for apparently innate vocalizations. Marmosets produce infant-specific vocalizations that disappear after the first postnatal months. However, it is yet unclear whether parental feedback is an obligate requirement for proper vocal development. Using quantitative measures to compare call parameters and vocal sequence structure we show that, in contrast to normally raised marmosets, marmosets that were separated from parents after the third postnatal month still produced infant-specific vocal behaviour at subadult stages. These findings suggest a significant role of social feedback on primate vocal development until the subadult stages and further show that marmoset monkeys are a compelling model system for early human vocal development.
Soluble urokinase receptor (suPAR) predicts microalbuminuria in patients at risk for type 2 diabetes mellitus
2017-01-16

Abstract Early identification of patients at risk of developing diabetic nephropathy is essential. Elevated serum concentrations of soluble urokinase receptor (suPAR) associate with diabetes mellitus and predict onset and loss of renal function in chronic kidney disease. We hypothesize, that suPAR may be an early risk indicator for diabetic nephropathy, preceding microalbuminuria. The relationship of baseline suPAR and incident microalbuminuria was assessed in a prospective long-term cohort of subjects at increased risk for type 2 diabetes (TULIP, n = 258). Association with albuminuria at later stages of disease was studied in a cross-sectional cohort with manifest type 2 diabetes (ICEPHA, n = 266). A higher baseline suPAR was associated with an increased risk of new-onset microalbuminuria in subjects at risk for type 2 diabetes (hazard ratio 5.3 (95% CI 1.1–25.2, p = 0.03) for the highest vs. lowest suPAR quartile). The proportion of subjects with prediabetes at the end of observation was higher in subjects with new-onset microalbuminuria. suPAR consistently correlated with albuminuria in a separate cohort with manifest type 2 diabetes. Elevated baseline suPAR concentrations independently associate with new-onset microalbuminuria in subjects at increased risk of developing type 2 diabetes. suPAR may hence allow for earlier risk stratification than microalbuminuria.
Unmet Needs in Dystonia: Genetics and Molecular Biology—How Many Dystonias?
2017-01-16

Genetic findings of the past years have provided ample evidence for a substantial etiologic heterogeneity of dystonic syndromes. While an increasing number of genes are being identified for Mendelian forms of isolated and combined dystonias using classical genetic mapping and whole-exome sequencing techniques, their precise role in the molecular pathogenesis is still largely unknown. Also, the role of genetic risk factors in the etiology of sporadic dystonias is still enigmatic. Only the systematic ascertainment and precise clinical characterization of very large cohorts with dystonia, combined with systematic genetic studies, will be able to unravel the complex network of factors that determine disease risk and phenotypic expression.
40 years of succession or mulching of abandoned grassland affect phosphorus fractions in soil
2017-01-16

Abstract Grazing and mowing commonly form part of agricultural management. Nowadays, these grassland management measures – complemented by low-cost treatments such as mulching – often aim at keeping the rural landscape open and at avoiding natural succession. The evaluation of these treatments has not yet accounted for the long-term perspective particularly important for soil phosphorus (P). In a four-decade long experiment in Southwestern Germany, the effects of mulching and natural succession on labile, moderately labile, and stable inorganic (Pi) and organic (Po) P fractions in soil of six sites (three in the Black Forest and three at the Swabian Alb) were studied. Our objectives were to test i) the effect of mulching or natural succession on P fractions in soil, and ii) whether the temporal development of P fractions in soil differs among mulching treatments and natural succession up to 40 years after abandonment of former land use. Special emphasis was paid to differences in bedrock combined with water regime. Soils developed on non-calcareous bedrock showed higher labile Po concentrations as compared to those developed on calcareous bedrock caused by reduced decomposition induced by water saturation and low quality of plant material. The normalization of P fractions to the respective site average revealed that mulching twice a year reduced concentrations of labile and moderately labile Pi, stable and total P in soil likely attributable to vertical transport of Pi. Comparing soil P fractions in 2014 to those of archived samples of 1975, succession resulted in a decrease in labile P fractions and increase in stable P fractions over time which could be explained by processes during soil development. Such processes were less pronounced in the mulching treatment indicating that decomposition of mulching material contributes to maintain P nutrition. In conclusion, mulching can be recommended as it contributes to maintaining P fractions bioavailable while at the same time promoting P limiting conditions.
The Great Trade Collapse and the Spanish Export Miracle: Firm-level Evidence from the Crisis
2017-01-16

We provide novel evidence on the micro-structure of international trade during the 2008 financial crisis and subsequent global recession by exploring a rich firm-level data set from Spain. The focus of our analysis is on changes at the extensive and intensive firm-level margins of trade, as well as on performance differences (jobs, productivity, and firm survival) across firms that differ in their export status. We find no adverse effects of the financial crisis on foreign market entry or exit, but a considerable increase in the export intensity of firms after the financial crisis. Moreover, we find that exporters were more resilient to the crisis than non-exporters. Finally, while exporters showed a significantly more favorable development of total factor productivity after 2009 than non-exporters, aggregate productivity declined substantially in a large number of industries in Spanish manufacturing. We also briefly explore two factors that might help explain the surprisingly strong export performance of Spain in the aftermath of the great trade collapse: improved aggregate competitiveness due to internal and external devaluation and a substitutive relationship between domestic and foreign sales at the firm level.
Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders
2017-01-17

Because of the high diagnostic yield of 36.8% and the possibility of identifying treatable diseases or the coexistence of several disease-causing variants, using exome sequencing as a first-line diagnostic approach in consanguineous families with neurodevelopmental disorders is recommended. Furthermore, the literature is enriched with 52 convincing candidate genes that are awaiting confirmation in independent families.
Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
2017-01-17

Significance Root hairs are unicellular extensions of the rhizodermis, providing anchorage and an increase in surface area for nutrient and water uptake. Their fast, tip-focused growth showcases root hairs as an excellent genetic model to study physiological and developmental processes on the cellular level. We uncovered a root hair phenotype that is dependent on putative Arabidopsis orthologs of the Guided Entry of Tail-anchored (TA) proteins (GET) pathway, which facilitates membrane insertion of TA proteins in yeast and mammals. We found that plants have evolved multiple paralogs of specific GET pathway components, albeit in a compartment-specific manner. In addition, we show that differential expression of pathway components causes pleiotropic growth defects, suggesting alternative pathways for TA insertion and additional functions of GET in plants.
Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age
2017-01-17

Significance One principle of human cerebral cortex is its lateralized functional architecture supporting processes such as language, precise motor control of the hands, and working memory. It has been shown that in elderly subjects such lateralized activations of dorsolateral and anterior prefrontal cortex vanish in working memory tasks, which is due to the corecruitment of corresponding regions in the other cerebral hemisphere. We show that such corecruitment of cross-hemispheric counterparts in prefrontal cortex is associated with subjectively demanding working memory tasks but not with age. This result suggests that prefrontal areas support us to maintain performance in challenging circumstances by additionally recruiting their non-specialized counterpart in the contralateral hemisphere.
Fused in Sarcoma Neuropathology in Neurodegenerative Disease
2017-01-17

Abnormal intracellular accumulation of the fused in sarcoma (FUS) protein is the characteristic pathological feature of cases of familial amyotrophic lateral sclerosis (ALS) caused by <i>FUS</i> mutations (ALS-<i>FUS</i>) and several uncommon disorders that may present with sporadic frontotemporal dementia (FTLD-FUS). Although these findings provide further support for the concept that ALS and FTD are closely related clinical syndromes with an overlapping molecular basis, important differences in the pathological features and results from experimental models indicate that ALS-<i>FUS</i> and FTLD-FUS have distinct pathogenic mechanisms.
Variation in Word Frequency Distributions: Definitions, Measures and Implications for a Corpus-Based Language Typology
2017-01-17

Word frequencies are central to linguistic studies investigating processing difficulty, learnability, age of acquisition, diachronic transmission and the relative weight given to a concept in society. However, there are few cross-linguistic studies on entire distributions of word frequencies, and even less on systematic changes within them. Here, we first define and test an exact measure for the relative difference between distributions – the Normalised Frequency Difference (NFD). We then apply this measure to parallel corpora in overall 19 languages, explaining systematic variation in the frequency distributions within the same language and across different languages. We further establish the NFD between lemmatised and un-lemmatised corpora as a frequency-based measure of inflectional productivity of a language. Finally, we argue that quantitative measures like the NFD can advance language typology beyond abstract, theory-driven expert judgments, towards more corpus-based, empirical and reproducible analyses.