julilili42/papers huggingface dataset:
Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation
2019-01-17

The aim of this study was to develop and validate a clinical and transplant-specific prognostic score using data from a large cohort of patients with myelodysplastic syndromes reported to the European Society for Blood and Marrow Transplantation registry. A Cox model was fitted to detect clinical and transplant-related variables prognostic of outcome. Then, cross-validation was performed to evaluate the validity and consistency of the model. Seven independent risk factors for survival were identified: age ≥50 years, matched unrelated donor, Karnofsky Performance Status <90%, very poor cytogenetics or monosomal karyotype, positive cytomegalovirus status of the recipient, blood blasts >1%, and platelet count ≤50 × 10<sup>9</sup>/L prior to transplantation. Incorporating these factors into a four-level risk score yielded hazard ratios for death, with low-risk (score of 0-1) as reference, of 2.02 (95% CI: 1.41-2.90) for the intermediate-risk group (score of 2-3), 3.49 (95% CI: 2.45-4.97) for the high-risk group (score of 4-5), and 5.90 (95% CI: 4.01-8.67) for the very high-risk group (score of >5). The score was predictive of survival, relapse-free survival, relapse, and non-relapse mortality (<i>P</i><0.001, respectively). Cross-validation yielded significant and reproducible improvement in prognostic ability with C-statistics being 0.609 (95% CI: 0.588-0.629) <i>versus</i> 0.555 for the <i>Gruppo Italiano Trapianto di Midollo Osseo</i> registry and 0.579 for the Center for Blood and Marrow Transplant Research registry. Prediction was even further augmented after applying a nomogram using age and platelets as continuous variables showing C-statistics of 0.628 (95% CI: 0.616-0.637). In conclusion, compared to existing prognostic systems, this proposed transplant-specific risk score offers improved performance with respect to post-transplant risk stratification in myelodysplastic syndromes.
Identifying corporate venture capital investors – A data-cleaning procedure
2019-01-17

The majority of research on corporate venture capital (CVC) relies on data retrieved from secondary databases. However, various databases define CVC differently. Generally, researchers rely on the definition of the used database. As a result, empirical CVC research is not readily comparable, and replicability across databases is often impossible. This article examines the scope and consistency of the most popular databases in CVC research: Eikon from Thomson Reuters and Dow Jones' VentureSource. The outcome is a replicable data-cleaning procedure based on an appropriate CVC definition. The article provides a necessary basis for the future discourse on CVC.
Factorial Structure of the Morningness-Eveningness-Stability-Scale (MESSi) and Sex and Age Invariance
2019-01-17

Assessing morningness-eveningness preferences (chronotype), an individual characteristic that is mirrored in daily mental and physiological fluctuations, is crucial given their overarching influence in a variety of domains. The current work aimed to investigate the best factor structure of an instrument recently presented to asses this characteristic: the Morningness-Eveningness-Stability-Scale improved (MESSi). For the first time, the originally proposed three-factor structure was pitched against a uni- and a two-factor solution. Another novelty was to establish that the best-fitting model would be invariant in relation to sex and age, two variables that influence chronotype. A Confirmatory Factor Analyses on the data obtained from a sample of 2096 German adults (age: 18-76; <i>M</i> = 25.5, <i>SD</i> = 7.64) revealed that the originally proposed three-factor structure of the MESSi - Morning Affect, Eveningness, and Distinctness - was the only one to achieve acceptable fit indicators. Furthermore, each scale obtained good internal consistency. In order to assess age invariance, following the literature on development and chronotype, our sample was divided into three age groups: 18-21 years, 22-31 years, and 32 years or older. Full measurement invariance of the three-factor model was found for sex and age. Regarding differences between sexes, females did not differ significantly from males in Morning Affect, but scored significantly lower on Eveningness and higher on Distinctness; this last result has been consistent across validation studies of the MESSi. With respect to age differences, the oldest group scored lower on Eveningness and Distinctness in comparison with the other two age-groups; the intermediate group (age: 22-31) scored lower on Morning Affect when compared to both the younger and older age groups. Additionally, both Eveningness and Distinctness were negatively correlated with age. This latter relation has been consistently reported in other validation studies. Our results reinforce the idea that the MESSi assesses three different components of chronotype in a reliable manner and that this instrument can be used to explore sex and age differences.
Blunted emotion‐modulated startle reflex in anorexia nervosa
2019-01-17

Abstract Objective Patients with anorexia nervosa (AN) often show difficulties in the perception, expression, and regulation of emotions and a strong avoidance of aversive feelings. According to psychobiological models, dietary restraint and accompanying weight loss may serve as a maladaptive mechanism of emotion regulation by attenuating aversive emotional states in AN, thereby contributing to the maintenance of the disorder. Method Twenty‐seven women with AN and 26 age‐matched healthy women were shown short film‐clips to elicit fear, sadness, amusement, and neutral emotional states. Eyeblink startle response was measured by electromyography in reaction to startle‐eliciting acoustic stimuli presented 12 times binaurally during each film‐clip. Results As compared to healthy controls, patients with AN showed a blunted startle response to the fear‐ but not to the sadness‐eliciting stimulus. Discussion The findings support the assumption that underweight is associated with attenuated emotional reactivity to fear‐eliciting material in AN. This is in line with the hypothesis that starvation and low body weight constitute a maladaptive mechanism of emotion regulation in AN, contributing to the maintenance of the disorder.
Heritability and Tinnitus
2019-01-17

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
Alternating Electric Fields (TTFields) Activate Cav1.2 Channels in Human Glioblastoma Cells
2019-01-18

Tumor treating fields (TTFields) represent a novel FDA-approved treatment modality for patients with newly diagnosed or recurrent glioblastoma multiforme. This therapy applies intermediate frequency alternating electric fields with low intensity to the tumor volume by the use of non-invasive transducer electrode arrays. Mechanistically, TTFields have been proposed to impair formation of the mitotic spindle apparatus and cytokinesis. In order to identify further potential molecular targets, here the effects of TTFields on Ca2+-signaling, ion channel activity in the plasma membrane, cell cycle, cell death, and clonogenic survival were tested in two human glioblastoma cell lines in vitro by fura-2 Ca2+ imaging, patch-clamp cell-attached recordings, flow cytometry and pre-plated colony formation assay. In addition, the expression of voltage-gated Ca2+ (Cav) channels was determined by real-time RT-PCR and their significance for the cellular TTFields response defined by knock-down and pharmacological blockade. As a result, TTFields stimulated in a cell line-dependent manner a Cav1.2-mediated Ca2+ entry, G1 or S phase cell cycle arrest, breakdown of the inner mitochondrial membrane potential and DNA degradation, and/or decline of clonogenic survival suggesting a tumoricidal action of TTFields. Moreover, inhibition of Cav1.2 by benidipine aggravated in one glioblastoma line the TTFields effects suggesting that Cav1.2-triggered signaling contributes to cellular TTFields stress response. In conclusion, the present study identified Cav1.2 channels as TTFields target in the plasma membrane and provides the rationale to combine TTFields therapy with Ca2+ antagonists that are already in clinical use.
Multiloop functional renormalization group for the two-dimensional Hubbard model: Loop convergence of the response functions
2019-01-18

We present a functional renormalization group (fRG) study of the two dimensional Hubbard model, performed with an algorithmic implementation which lifts some of the common approximations made in fRG calculations. In particular, in our fRG flow; (i) we take explicitly into account the momentum and the frequency dependence of the vertex functions; (ii) we include the feedback effect of the self-energy; (iii) we implement the recently introduced multiloop extension which allows us to sum up all the diagrams of the parquet approximation with their exact weight. Due to its iterative structure based on successive one-loop computations, the loop convergence of the fRG results can be obtained with an affordable numerical effort. In particular, focusing on the analysis of the physical response functions, we show that the results become independent from the chosen cutoff scheme and from the way the fRG susceptibilities are computed, i.e., either through flowing couplings to external fields, or through a “post-processing” contraction of the interaction vertex at the end of the flow. The presented substantial refinement of fRG-based computation schemes paves a promising route towards future quantitative fRG analyses of more challenging systems and/or parameter regimes.
Lizards at the Peak: Physiological Plasticity Does Not Maintain Performance in Lizards Transplanted to High Altitude
2019-01-18

Warming climates are facilitating the range expansion of many taxa to habitats that were formerly thermally inhospitable, including to higher latitudes and elevations. The potential for such colonization, however, varies widely among taxa. Because environmental factors may interact to affect colonization potential, an understanding of underlying physiological and behavioral mechanisms is necessary to predict how species will respond to potentially suitable habitats. For example, temperature and oxygen availability will interact to shape physiological and performance traits. Our model species, the wall lizard, Podarcis muralis, is a widely distributed ectotherm that continues to expand its range in Europe despite being limited by cold temperatures at high elevations and latitudes. To test the potential for organisms to expand to warming high-altitude environments, we conducted a transplant experiment to quantify the within-individual effects of high-altitude hypoxia on physiological and performance traits. Transplanted lizards maintained individual differences in physiological traits related to oxygen capacity and metabolism (hemoglobin concentration, hematocrit, and peak postexhaustion metabolic rate), as well as performance traits tied to fitness (sprint speed and running endurance). Although lizards altered blood biochemistry to increase oxygen-carrying capacity, their performance was reduced at high altitude. Furthermore, lizards at high altitude suffered a rapid loss of body condition over the 6-wk experiment, suggesting an energetic cost to hypoxia. Taken together, this demonstrates a limited potential for within-individual plasticity to facilitate colonization of novel high-altitude environments.
Formation of green rust and elemental sulfur in an analogue for oxygenated ferro-euxinic transition zones of Precambrian oceans
2019-01-18

For much of the Precambrian era, the bulk ocean was anoxic and Fe(II) rich (ferruginous), except for the first development of shallow ocean oxygenation and temporally/spatially restricted sulfide-rich waters (euxinia) along productive continental margins in the late Archean, which prevailed throughout much of the remaining Precambrian. There is little detail pertaining to transition zones between ferruginous, euxinic, and oxic seawater over the continental shelf that may have played an important role in shaping the composition of the underlying sediment. Here we present spectroscopic data on the Fe and sulfur mineralogy in the Arvadi Spring (Switzerland), a proposed analogue for such conditions. Our study reveals green rust, ferrihydrite, and lepidocrocite as the main Fe minerals. Because the reactivity of green rust differs from that of ferric hydroxides and Fe(II) sulfides, it is important to understand its role in the transfer of metals and nutrients from seawater to underlying sediments, if those sediments are to be used as chemical archives of paleo-seawater. We observed elemental sulfur (S <sup>0</sup> ) as the dominant sulfur precipitate and found indications for its role in pyrite formation, implying that S <sup>0</sup> could have had a similar role in Precambrian deposition of pyrite-poor or pyrite-rich sediments.
Dual studies in different cultural contexts: The work-study model in Germany and its applicability to China
2019-01-18

This paper, based on data collected from questionnaires distributed among German students and from interviews with university professors and contacts in cooperating companies in both Germany and China, evaluates dual studies in Germany and their applicability to China. The study finds that most students are satisfied with the theory phase and the practical phase. Practical experience and grants from companies are mentioned as important advantages of dual studies. In addition, expert interviews carried out in Germany show that students acquire both professional knowledge and occupational skills in the course of their dual studies. Interviews with Chinese experts point to the fact that the German model of dual studies could be applicable to China. Therefore, dual studies at Chinese application-oriented universities which interlink theory with practice and offer both a Bachelor’s degree and a professional qualification in 3- to 4-year programmes could be an attractive alternative for Chinese students.
Fully-automated synthesis of power management controllers from UPF
2019-01-18

We present a methodology for automatic synthesis of power management controllers for System-on-Chip designs by using an extended version of the Unified Power Format (UPF). Our methodology takes an SoC design and a UPF-based power design, and automatically generates a power management controller in Verilog/VHDL that implements the power state machine specified in UPF. It performs a priority-based scheduling for all power state machine actions, connects each power management signal to the corresponding logic wire in the UPF design and integrates the controller into the System-on-Chip using a configurable bus interface. We implemented the proposed approach as a plugin for Synopsys Design Compiler to close the gap in today's power management flows and evaluated it by a RISC-V System-on-Chip.
SIMULTime
2019-01-18

Nowadays, product lines are common practice in the embedded systems domain as they allow for substantial reductions in development costs and the time-to-market by a consequent application of design paradigms such as variability and structured reuse management. In that context, accurate and fast timing predictions are essential for an early evaluation of all relevant variants of a product line concerning target platform properties. Context-sensitive simulations provide attractive benefits for timing analysis. Nevertheless, these simulations depend strongly on a single configuration pair of compiler and hardware platform. To cope with this limitation, we present SIMULTime, a new technique for context-sensitive timing simulation based on the software intermediate representation. The assured simulation throughput significantly increases by simulating simultaneously different hardware hardware platforms and compiler configurations. Multiple accurate timing predictions are produced by running the simulator only once. Our novel approach was applied on several applications showing that SIMULTime increases the average simulation throughput by 90% when at least four configurations are analyzed in parallel.
Spectrum of GABAA receptor variants in epilepsy
2019-01-19

Purpose of review Recent publications point to an increasingly important role of variants in genes encoding GABA A receptor subunits associated with both common and rare forms of epilepsies. The aim of this review is to give an overview of the current clinical phenotypes, genetic findings and pathophysiological mechanisms related to GABA A receptor variants. Recent findings Early work showed that inherited variants in GABRG2 and GABRA1 cause relatively mild forms of monogenic epilepsies in large families. More recent studies have revealed that de novo variants in several GABA A receptor genes cause severe developmental and epileptic encephalopathies, inherited variants cause remarkably variable phenotypes within the same pedigrees ranging from asymptomatic carriers to developmental and epileptic encephalopathies, and variants in all GABA A receptor genes are enriched in common forms of epilepsy, namely rolandic epilepsy and genetic generalized epilepsy. Analyses from cellular expression systems and mouse models suggest that all variants cause a loss of GABA A receptor function resulting in GABAergic disinhibition. Summary Genetic studies have revealed a crucial role of the GABAergic system in the underlying pathogenesis of various forms of common and rare epilepsies. Our understanding of functional consequences of GABA A receptor variants provide an opportunity to develop precision-based therapeutic strategies that are hopefully free from the side-effect burden seen with currently available GABAergic drugs.
Magnetic Resonance–based Assessment of Myocardial 2-Dimensional Strain Using Feature Tracking
2019-01-19

Purpose: Myocardial strain analysis is a promising tool for the detection of subtle but relevant alterations of left ventricular function, also in asymptomatic subjects. Thus, we determined the feasibility of cardiac magnetic resonance–based 2D global strain analysis using feature tracking and its association with cardiovascular risk factors in a sample from the general population. Materials and Methods: Subjects without a history of cardiocerebrovascular disease were enrolled in a substudy of the population-based KORA (Cooperative Health Research in the Region of Augsburg) cohort. In all participants with the absence of late gadolinium enhancement, longitudinal and circumferential global strains were measured on Cine SSFP imaging (TR: 29.97 ms, TE: 1.46 ms, ST: 8 mm), using a semiautomatic segmentation algorithm (CVI42, Circle, Canada). Differences in strain values according to age, sex, body mass index, hypertension, diabetes mellitus, and hyperlipidemia were derived using linear regression analysis. Results: Among 360 subjects (mean age, 56.2±9.2 y, 57% male), the average global systolic radial strain was 40.1±8.2%, circumferential 19.9±2.7%, and longitudinal 19.8±3.2%. Male sex was associated with decreased global strain values, independent of the strain direction (all P &lt;0.001). Although many cardiovascular risk factors were correlated with strain in univariate analysis, mainly waist-to-hip ratio and HbA1c remained associated with decreased radial and circumferential strains in fully adjusted models. Similarly, higher radial and circumferential strains were observed in older subjects (β=0.14, P =0.01 and β=0.11, P =0.04, respectively). Conclusions: Strain analysis using magnetic resonance feature tracking is feasible in population-based cohort studies and shows differences with respect to age and sex as well as an independent association with markers of metabolic syndrome.
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
2019-01-19

Phosphoinositide 3-kinase β (PI3Kβ) is regulated by receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), and small GTPases such as Rac1 and Rab5. Our lab previously identified two residues (Gln<sup>596</sup> and Ile<sup>597</sup>) in the helical domain of the catalytic subunit (p110β) of PI3Kβ whose mutation disrupts binding to Rab5. To better define the Rab5-p110β interface, we performed alanine-scanning mutagenesis and analyzed Rab5 binding with an <i>in vitro</i> pulldown assay with GST-Rab5<sup>GTP</sup> Of the 35 p110β helical domain mutants assayed, 11 disrupted binding to Rab5 without affecting Rac1 binding, basal lipid kinase activity, or Gβγ-stimulated kinase activity. These mutants defined the Rab5-binding interface within p110β as consisting of two perpendicular α-helices in the helical domain that are adjacent to the initially identified Gln<sup>596</sup> and Ile<sup>597</sup> residues. Analysis of the Rab5-PI3Kβ interaction by hydrogen-deuterium exchange MS identified p110β peptides that overlap with these helices; no interactions were detected between Rab5 and other regions of p110β or p85α. Similarly, the binding of Rab5 to isolated p85α could not be detected, and mutations in the Ras-binding domain (RBD) of p110β had no effect on Rab5 binding. Whereas soluble Rab5 did not affect PI3Kβ activity <i>in vitro</i>, the interaction of these two proteins was critical for chemotaxis, invasion, and gelatin degradation by breast cancer cells. Our results define a single, discrete Rab5-binding site in the p110β helical domain, which may be useful for generating inhibitors to better define the physiological role of Rab5-PI3Kβ coupling <i>in vivo</i>.
Highly replicated sampling reveals no diurnal vertical migration but stable species-specific vertical habitats in planktonic foraminifera
2019-01-20

Diurnal vertical migration (DVM) is a widespread phenomenon in the upper ocean, but it remains unclear to what degree it also involves passively transported micro- and meso-zooplankton. These organisms are difficult to monitor by &lt;i&gt;in situ&lt;/i&gt; sensing and observations from discrete samples are often inconclusive. Prime examples of such ambiguity are planktonic foraminifera, where contradictory evidence for DVM continues to cast doubt on the stability of species vertical habitats, which introduces uncertainties in geochemical proxy interpretation. To provide a robust answer, we carried out highly replicated randomized sampling with 41 vertically resolved plankton net hauls taken within 26 hours in a confined area of 400 km&lt;sup&gt;2&lt;/sup&gt; in the tropical North Atlantic, where DVM in larger plankton occurs. Manual enumeration of planktonic foraminifera cell density consistently reveals the highest total cell concentrations in the surface mixed layer (top 50 m) and analysis of cell density in seven individual species representing different shell sizes, life strategies and presumed depth habitats reveals consistent vertical habitats not changing over the 26 hours sampling period. These observations robustly reject the existence of DVM in planktonic foraminifera in a setting where DVM occurs in other organisms.