julilili42/papers huggingface dataset:
Reporting and interpreting non-significant results in animal cognition research
2023-03-09

How statistically non-significant results are reported and interpreted following null hypothesis significance testing is often criticized. This issue is important for animal cognition research because studies in the field are often underpowered to detect theoretically meaningful effect sizes, i.e. , often produce non-significant p -values even when the null hypothesis is incorrect. Thus, we manually extracted and classified how researchers report and interpret non-significant p -values and examined the p -value distribution of these non-significant results across published articles in animal cognition and related fields. We found a large amount of heterogeneity in how researchers report statistically non-significant p -values in the result sections of articles, and how they interpret them in the titles and abstracts. Reporting of the non-significant results as “No Effect” was common in the titles (84%), abstracts (64%), and results sections (41%) of papers, whereas reporting of the results as “Non-Significant” was less common in the titles (0%) and abstracts (26%), but was present in the results (52%). Discussions of effect sizes were rare (&lt;5% of articles). A p -value distribution analysis was consistent with research being performed with low power of statistical tests to detect effect sizes of interest. These findings suggest that researchers in animal cognition should pay close attention to the evidence used to support claims of absence of effects in the literature, and—in their own work—report statistically non-significant results clearly and formally correct, as well as use more formal methods of assessing evidence against theoretical predictions.
Curricular representation of neurogastroenterology: A survey among medical students in Germany
2023-03-09

Abstract Background Neurogastroenterological disorders (NGDs) are highly prevalent and substantially impact patients' quality of life. Effective treatment of NGDs depends on the competence and training of medical caregivers. Students' perceived competence in neurogastroenterology and its place in medical school curricula are assessed in this study. Methods A multi‐center digital survey among medical students was conducted at five universities. Self‐ratings of competence regarding basic mechanisms, diagnosis, and treatment of six chronic medical conditions were assessed. These included irritable bowel syndrome (IBS), gastroesophageal reflux disease, and achalasia. Ulcerative colitis, hypertension, and migraine were included as references. Key Results Of 231 participants, 38% remembered that neurogastroenterology was covered in their curriculum. Highest competence ratings were stated for hypertension and the lowest for IBS. These findings were identical for all institutions irrespective of their curricular model and demographic parameters. Students who remembered neurogastroenterology as a part of their curriculum reported higher competence ratings. According to 72% of students, NGDs should be highlighted more prominently in the curriculum. Conclusions &amp; Inferences Despite its epidemiological relevance, neurogastroenterology is only weakly represented in medical curricula. Students report low levels of subjective competence in handling NGDs. In general, assessing the learners' perspective on an empirical basis may enrichen the process of national standardization of medical school curricula.
The role of the body in electronic sport: a scoping review
2023-03-09

Abstract The popularity of competitive computer and videogaming, also known as electronic sport (esport), has been rising rapidly during the past decades. Because of many parallels with traditional sports, like competitiveness, skill requirements, degree of professionalization, or the way it is portrayed in the media, esport has been adopted as part of the sport canon in many countries. Still, critics argue that playing computer games lacks the physicality commonly seen in traditional sports. A significant part of the competition is mediated through digital platforms and the spotlight shifts from the players’ appearance and actions to their digital avatars. This paper takes on this issue by exploring existing evidence about the role of the body in esport via a scoping review approach. According to the findings of 47 studies, the body’s role in esport is akin to that in traditional sport, including specific motoric requirements or biometric responses. Beyond that, the body can be seen as a link between the digital and physical worlds. Players embody digital avatars in the form of esport-specific movements, transfer of norms and ideals, and identification with the in-game characters. Future research can use this review as a basis for scientific approaches to individual phenomena regarding corporeality in esport and inter-corporeality.
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation
2023-03-09

Abstract Hit generation is a crucial step in drug discovery that will determine the speed and chance of success of identifying drug candidates. Many strategies are now available to identify chemical starting points, or hits, and each biological target warrants a tailored approach. In this set of best practices, we detail the essential approaches for target centric hit generation and the opportunities and challenges they come with. We then provide guidance on how to validate hits to ensure medicinal chemistry is only performed on compounds and scaffolds that engage the target of interest and have the desired mode of action. Finally, we discuss the design of integrated hit generation strategies that combine several approaches to maximize the chance of identifying high quality starting points to ensure a successful drug discovery campaign.
Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia
2023-03-09

Abstract Background Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition ( Myosteatosis ). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral myosteatosis with lumbar disc degeneration in individuals with impaired glucose metabolism and normoglycaemic controls. Methods In total, 304 individuals (mean age: 56.3 ± 9.1 years, 53.6% male sex, mean body mass index [BMI]: 27.6 ± 4.7 kg/m 2 ) from a population‐based cohort study who underwent 3‐Tesla whole‐body chemical‐shift‐encoded (six echo times) and T2‐weighted single‐shot‐fast‐spin‐echo MRI were included. Lumbar disc degeneration was assessed at motion segments L1 to L5, categorized according to the Pfirrmann score and defined as Pfirrmann grade &gt; 2 and/or disc bulging/herniation on at least one segment. Fat content of the autochthonous back muscles and the quadratus lumborum muscle was quantified as proton density fat fraction (PDFF muscle ). Logistic regression models adjusted for age, sex, BMI and regular physical activity were calculated to evaluate the association between PDFF muscle and outcome IVDD. Results The overall prevalence of IVDD was 79.6%. There was no significant difference in the prevalence or severity distribution of IVDD between participants with or without impaired glucose metabolism (77.7% vs. 80.7%, P = 0.63 and P = 0.71, respectively). PDFF muscle was significantly and positively associated with an increased risk for the presence of IVDD in participants with impaired glycaemia when adjusted for age, sex and BMI (PDFF autochthonous back muscles : odds ratio [OR] 2.16, 95% confidence interval [CI] [1.09, 4.3], P = 0.03; PDFF quadratus lumborum : OR 2.01, 95% CI [1.04, 3.85], P = 0.04). After further adjustment for regular physical activity, the results attenuated, albeit approaching statistical significance (PDFF autochthonous back muscles : OR 1.97, 95% CI [0.97, 3.99], P = 0.06; PDFF quadratus lumborum : OR 1.86, 95% CI [0.92, 3.76], P = 0.09). No significant associations were shown in healthy controls (PDFF autochthonous back muscles : OR 0.62, 95% CI [0.34, 1.14], P = 0.13; PDFF quadratus lumborum : OR 1.06, 95% CI [0.6, 1.89], P = 0.83). Conclusions Paravertebral myosteatosis is positively associated with intervertebral disc disease in individuals with impaired glucose metabolism, independent of age, sex and BMI. Regular physical activity may confound these associations. Longitudinal studies will help to better understand the pathophysiological role of skeletal muscle in those with concomitant disturbed glucose haemostasis and intervertebral disc disease, as well as possible underlying causal relationships.
Multiperspective Teaching of Unknown Objects via Shared-gaze-based Multimodal Human-Robot Interaction
2023-03-09

For successful deployment of robots in multifaceted situations, an understanding of the robot for its environment is indispensable. With advancing performance of state-of-the-art object detectors, the capability of robots to detect objects within their interaction domain is also enhancing. However, it binds the robot to a few trained classes and prevents it from adapting to unfamiliar surroundings beyond predefined scenarios. In such scenarios, humans could assist robots amidst the overwhelming number of interaction entities and impart the requisite expertise by acting as teachers. We propose a novel pipeline that effectively harnesses human gaze and augmented reality in a human-robot collaboration context to teach a robot novel objects in its surrounding environment. By intertwining gaze (to guide the robot's attention to an object of interest) with augmented reality (to convey the respective class information) we enable the robot to quickly acquire a significant amount of automatically labeled training data on its own. Training in a transfer learning fashion, we demonstrate the robot's capability to detect recently learned objects and evaluate the influence of different machine learning models and learning procedures as well as the amount of training data involved. Our multimodal approach proves to be an efficient and natural way to teach the robot novel objects based on a few instances and allows it to detect classes for which no training dataset is available. In addition, we make our dataset publicly available to the research community, which consists of RGB and depth data, intrinsic and extrinsic camera parameters, along with regions of interest.
Differential Expression and Clinical Relevance of C-X-C Motif Chemokine Receptor 4 (CXCR4) in Renal Cell Carcinomas, Benign Renal Tumors, and Metastases
2023-03-09

C-X-C Motif Chemokine Receptor 4 (CXCR4) is part of the human chemokine system and involved in progression and metastasis in renal cell carcinoma (RCC). However, the role of CXCR4 protein expression in RCC remains controversial. In particular, data regarding the subcellular distribution of CXCR4 in RCC and RCC metastasis as well as CXCR4 expression in renal tumors of variant histology are limited. The aim of the present study was the evaluation of the differential CXCR4 expression in RCC primary tumor and metastatic tissue as well as in variant renal histologies. In addition, the prognostic capacity of CXCR4 expression in organ-confined clear cell RCC (ccRCC) was evaluated. Three independent renal tumor cohorts (primary ccRCC cohort n1 = 64; cohort of various histological entities n2 = 146; metastatic RCC tissue cohort n3 = 92) were evaluated using tissue microarrays (TMA). After immunohistochemical staining for CXCR4, nuclear and cytoplasmic expression patterns were evaluated. CXCR4 expression was correlated with validated pathologic prognosticators, clinical data, and overall and cancer-specific survival. Positive cytoplasmic staining was observed in 98% of the benign and 38.9% of the malignant samples. Nuclear staining was positive for 94.1% of the benign samples and 83% of the malignant samples. The median cytoplasmic expression score was found to be higher in benign tissue than in ccRCC (130.00 vs. 0.00); median nuclear expression score analysis indicated the opposite (56.0 vs. 71.0). Within malignant subtypes, the highest expression score was seen in papillary renal cell carcinomas (cytoplasmic: 117.50, nuclear: 41.50). Within benign renal tumors, high cytoplasmic and nuclear CXCR4 expression scores were seen for oncocytomas (cytoplasmic: 100.00, nuclear: 31.00). Expression scores in RCC metastasis ranked between benign renal tissue and ccRCC in cytoplasmic and nuclear expression. Cytoplasmic CXCR4 expression was identified as a prognostic factor for OS and CSS (p = 0.042; p = 0.019). Multivariate analysis including clinicopathological parameters did not reveal an independent prognostic character of CXCR4 expression. CXCR4 expression differs significantly within benign lesions and renal neoplasms. Cytoplasmic and nuclear expression of CXCR4 could be detected across all RCC subtypes. The prognostic value of CXCR4 in ccRCC was confirmed in univariate analysis.
Cardiorespiratory polysomnography recordings of neonates with Robin sequence
2023-03-09

The dataset consists of 19 whole night recordings of neonates that were obtained using cardiorespiratory polysomnography. The recordings were performed at the Department of Neonatology at Tübingen University Hospital between May 2020 and April 2021. Each recording (.edf file) is accompanied by an annotation file (.txt file) that contains time timestamps for physiological events of interest (Apneas, Hypopneas, Hypoxias, Movement).
Cardiorespiratory polysomnography recordings of neonates with Robin sequence
2023-03-09

The dataset consists of 19 whole night recordings of neonates that were obtained using cardiorespiratory polysomnography.\\n\\n\\nThe recordings were performed at the Department of Neonatology at T&amp;uuml;bingen University Hospital between May 2020 and April 2021.\\n\\n\\nEach recording (.edf file) is accompanied by an annotation file (.txt file) that contains time timestamps for physiological events of interest (Apneas, Hypopneas, Hypoxias, Movement).
Artificial Intelligence Solutions for Health 4.0: Overcoming Challenges and Surveying Applications
2023-03-10

In recent years, the term Health 4.0 has appeared in health services and is related to the concept of Industry 4.0. The term Health 4.0 focuses on replacing traditional care in hospitals and medical clinics with home health services that are based on artificial intelligence techniques through the use of telemedicine applications that allow the monitoring of patients in a virtual environment. This term is utilized to represent digital change in the healthcare sector. Governments aim to develop the level of medical care in hospitals and clinics to ensure the provision of healthcare benefits at low costs and increase patient satisfaction. It has become vital for hospitals to grow their environment into digital environments in their services through the use of a set of computer programs based on artificial intelligence. Artificial intelligence techniques in Health 4.0 provide a set of procedures that benefit patients and healthcare workers, including early diagnosis, make inquiries into treatment, data analysis, reports on the patient's condition, and others. The primary purpose of this article is to determine the significance of Health 4.0 and AI techniques in healthcare by mentioning the most important benefits and weaknesses of using AI techniques in healthcare.
Testing erosional and kinematic drivers of exhumation in the central Himalaya
2023-03-10

This study investigates the influence of fault geometry, kinematics, and displacement on the exhumation history of the central Himalaya using geologic mapping constraints, a new interpreted cross-section, and a suite of 176 thermochronometer ages through the Marsyangdi valley in central Nepal. Guided by the cross-section, we integrate a forward model of fold-thrust belt evolution with a 2D thermokinematic model. Model-predicted and measured thermochronometer ages were compared to evaluate the sensitivity of thermochronometer ages to the geometry and location of structures, and their rates of deformation. Results indicate 84% of the measured data can be reproduced with a largely in-sequence system of faulting where displacement occurs on the Main Central thrust (MCT) from 23-16 Ma, the Ramgarh-Munsiari thrust (RMT) from 16-7.5 Ma, the Trishuli thrust (TT) from 7.5-6 Ma and the Main Boundary thrust (MBT) from 6-3 Ma. Our cross-section solution shows the development of a duplex that initiates at 4 Ma with the TT and MBT as the roof thrust. The duplex is translated over the Main Himalayan thrust (MHT) ramp, concurrent with forward propagation of faulting in the synorogenic Siwaliks from 3 Ma to present. Notably, the 2-0.5 Ma apatite fission-track ages between the MCT and Tethyan strata 45 km north of the MCT are not reproduced by the wide range of in-sequence deformation scenarios we explored. Instead, these data are consistent with simulations that include significant displacement on two out-of-sequence (OOS) faults in the last ∼1 Ma: 10 km of OOS faulting near the MCT followed by 5 km of displacement on a fault 15 km south of the MCT. Modeled OOS thrusting both builds significant topography in the hinterland and flexurally suppresses topography in the foreland. Consequently, our preferred kinematic solution has ∼10 km of final fault motion in the Siwaliks to rebuild topography at the MBT and the active MFT from ∼0.5 Ma to the present. Modeled exhumation rates are highly variable through time, and are highest during translation of rocks over high (∼10 km) ramps and during significant changes in architecture, such as duplex formation and OOS faulting. Notably high exhumation rates include 10.5 mm/yr during the first 4 Myr of MCT motion, 4-6 mm/yr at ∼7 Ma, due to the translation over an ∼10 km high TT ramp, and 7-12 mm/yr from 4 Ma to present driven by the development of the duplex and its translation over the MHT ramp, followed by OOS thrusting. The high (7-12 mm/yr) exhumation rates documented here from 4 Ma, correlate with a time of distinct climate change, including strengthening of the monsoon, and northern hemisphere glaciation, lending support to potential climate-tectonic feedbacks.
Work expectations, their fulfillment, and exhaustion among radiologists of all career levels: what can be learned from the example of Germany
2023-03-10

Abstract Objectives To evaluate work expectations of radiologists at different career levels, their fulfillment, prevalence of exhaustion, and exhaustion-associated factors. Methods A standardized digital questionnaire was distributed internationally to radiologists of all career levels in the hospital and in ambulatory care via radiological societies and sent manually to 4500 radiologists of the largest German hospitals between December 2020 and April 2021. Statistics were based on age- and gender-adjusted regression analyses of respondents working in Germany (510 out of 594 total respondents). Results The most frequent expectations were “joy at work” (97%) and a “good working atmosphere” (97%), which were considered fulfilled by at least 78%. The expectation of a “structured residency within the regular time interval” (79%) was more frequently judged fulfilled by senior physicians (83%, odds ratio (OR) 4.31 [95% confidence interval (95% CI) 1.95–9.52]), chief physicians (85%, 6.81 [95% CI 1.91–24.29]), and radiologists outside the hospital (88%, 7.59 [95% CI 2.40–24.03]) than by residents (68%). Exhaustion was most common among residents (physical exhaustion: 38%; emotional exhaustion: 36%), in-hospital specialists (29%; 38%), and senior physicians (30%; 29%). In contrast to paid extra hours, unpaid extra hours were associated with physical exhaustion (5–10 extra hours: OR 2.54 [95% CI 1.54–4.19]). Fewer opportunities to shape the work environment were related to a higher probability of physical (2.03 [95% CI 1.32–3.13]) and emotional (2.15 [95% CI 1.39–3.33]) exhaustion. Conclusions While most radiologists enjoy their work, residents wish for more training structure. Ensuring payment of extra hours and employee empowerment may help preventing burnout in high-risk groups. Key Points • Most important work expectations of radiologists who work in Germany are “joy at work,” a “good working atmosphere,” “support for further qualification,” and a “structured residency within the regular time interval,” with the latter containing potential for improvement according to residents. • Physical and emotional exhaustion are common at all career levels except for chief physicians and for radiologists who work outside the hospital in ambulatory care. • Exhaustion as a major burnout criterion is associated with unpaid extra hours and reduced opportunities to shape the work environment.
Electron-Beam Source with a Superconducting Niobium Tip
2023-03-10

Electron-beam sources are foundational in high-resolution electron microscopy and spectroscopy, but applications have been limited due to their relatively large energy spread. The authors fabricate a monocrystalline niobium nanotip electron field emitter and characterize it in superconducting and normal-conducting regimes. This bright, stable, coherent electron beam source features an exceptionally narrow energy spread. The authors also study the role of xenon adsorption and two-electron correlations. This work may improve aberration-corrected microscopy and electron energy-loss spectroscopy and enable high-resolution vibrational spectroscopy or quantum electron microscopy.
Statin Treatment Is Associated with Alterations in the Platelet Lipidome
2023-03-10

Background Platelets are key players in the pathophysiology of coronary artery disease (CAD) and platelet hyperreactivity leads to increased risk of developing adverse cardiovascular events. Further, significant changes in the platelet lipidome occur in patients with acute coronary syndrome (ACS) and critically regulated lipids lead to platelet hyperresponsiveness. Statin treatment is crucial in the treatment and prevention of patients with CAD by remodeling lipid metabolism. Objective In this study, we investigate the platelet lipidome of CAD patients by untargeted lipidomics, highlighting significant changes between statin-treated and naïve patients. Methods We characterized the platelet lipidome in a CAD cohort (n = 105) by an untargeted lipidomics approach using liquid chromatography coupled to mass spectrometry. Results Among the annotated lipids, 41 lipids were significantly upregulated in statin-treated patients, whereas 6 lipids were downregulated compared to naïve patients. The most prominent upregulated lipids in statin-treated patients belong to the class of triglycerides, cholesteryl esters, palmitic acid, and oxidized phospholipids, whereas mainly glycerophospholipids were downregulated compared to untreated patients. A more pronounced effect of statin treatment on the platelet lipidome was observed in ACS patients. We further highlight a dose-dependent influence on the platelet lipidome. Conclusion Our results reveal that the platelet lipidome is altered in CAD patients with statin treatment and upregulated lipids embody mainly characteristic triglycerides, whereas downregulated lipids mostly compromise glycerophospholipids, which may play a role in the pathophysiology of CAD. Results of this study may contribute to the understanding of statin treatment softening the lipid phenotype.