julilili42/papers huggingface dataset:
Leptin Is Not Essential for Obesity-Associated Hypertension
2019-01-01

&lt;b&gt;&lt;i&gt;Background and Objective:&lt;/i&gt;&lt;/b&gt; Hyperleptinemia is supposed to play a causal role in the development of obesity-associated hypertension, possibly via increased sympathetic tone. Hence patients with congenital leptin deficiency should be hypotensive and their low blood pressure should increase under leptin substitution. &lt;b&gt;&lt;i&gt;Subjects and Methods:&lt;/i&gt;&lt;/b&gt; To test this assumption, we examined ambulatory blood pressure, resting heart rate, Schellong test results, cold pressor test results, heart rate variability, catecholamine metabolites, and aldosterone levels in 6 patients with congenital leptin deficiency before as well as 2–7 days and 7–14 months after the start of leptin substitution. Ambulatory blood pressure was also examined in 3 patients with biallelic disease-causing variants in the leptin receptor gene. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Contrary to our expectations, even before leptin substitution, 1 patient with biallelic leptin receptor gene variants and 4 patients with leptin deficiency had been suffering from hypertension. Short-term substitution with leptin increased blood pressure further in 3 out of 4 patients (from 127.0 ± 11.7 to 133.8 ± 10.6 mm Hg), concomitant with an increase in resting heart rate as well as in heart rate during the Schellong test in all patients (from 87.6 ± 7.7 to 99.9 ± 11.0 bpm, &lt;i&gt;p&lt;/i&gt; = 0.031, and from 102.9 ± 13.5 to 115.6 ± 11.3 bpm, &lt;i&gt;p&lt;/i&gt; = 0.031, respectively). Furthermore, the systolic blood pressure response during the cold pressor test increased in 4 out of 6 patients. Unexpectedly, catecholamine metabolites and aldosterone levels did not increase. After long-term leptin substitution and weight loss, the resting heart rate decreased in 4 out of 6 patients compared to baseline, and in all patients below the heart rate seen immediately after the start of therapy (from 99.9 ± 11.0 to 81.7 ± 5.4 bpm; &lt;i&gt;p&lt;/i&gt; = 0.031). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; These results show that obesity-associated hypertension does not depend on the presence of leptin. However, short-term leptin substitution can increase the blood pressure and heart rate in obese humans with leptin deficiency, indicating that leptin plays at least an additive role in obesity-associated hypertension. The mechanisms behind this are not clear but might include an increase in regional sympathetic tone.
Time of cold ischemia and delayed graft function in a cohort of renal transplant patients in a reference center
2019-01-01

There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009-2013. The incidence of delayed graft function was 18.4% (<i>n</i> = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12-18 hours group (OR 2.06, 95% CI 1.02-4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57-7.27). The risk of acute rejection did not increase with longer cold ischemia (<i>p</i> = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88-1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant.
The mystery of Mystriosaurus: redescribing the poorly known Early Jurassic teleosauroid thalattosuchians Mystriosaurus laurillardi and Steneosaurus brevior
2019-01-01

The genus Mystriosaurus, established by Kaup in 1834, was one of the first thalattosuchian genera to be named. The holotype, an incomplete skull from the lower Toarcian Posidonienschiefer Formation of Altdorf (Bavaria, southern Germany), is poorly known with a convoluted taxonomic history. For the past 60 years, Mystriosaurus has been considered a subjective junior synonym of Steneosaurus. However, our reassessment of the Mystriosaurus laurillardi holotype demonstrates that it is a distinct and valid taxon. Moreover, we find the holotype of “Steneosaurus” brevior, an almost complete skull from the lower Toarcian Whitby Mudstone Formation of Whitby (Yorkshire, UK), to be a subjective junior synonym of M. laurillardi. Mystriosaurus is diagnosed in having: a heavily and extensively ornamented skull; large and numerous neurovascular foramina on the premaxillae, maxillae and dentaries; anteriorly oriented external nares; and four teeth per premaxilla. Our phylogenetic analyses reveal M. laurillardi to be distantly related to Steneosaurus bollensis, supporting our contention that they are different taxa. Interestingly, our analyses hint that Mystriosaurus may be more closely related to the Chinese teleosauroid (previously known as Peipehsuchus) than any European form.
Effects of Breath-Hold Deep Diving on the Pulmonary System
2019-01-01

This short review focuses on pulmonary injury in breath-hold (BH) divers. When practicing their extreme leisure sport, they are exposed to increased pressure on pulmonary gas volumes, hypoxia, and increased partial gas pressures. Increasing ambient pressures do present a serious problem to BH deep divers, because the semi-rigid thorax prevents the deformation required by the Boyle-Mariotte law. As a result, a negative-pressure barotrauma (lung squeeze) with acute hemoptysis is not uncommon. Respiratory maneuvers such as glossopharyngeal insufflation (GI) and glossopharyngeal exsufflation (GE) are practiced to prevent lung squeeze and to permit equalizing the paranasal sinuses and the middle ear. GI not only impairs venous return, thereby provoking hypotension and even fainting, but also produces intrathoracic pressures likely to induce pulmonary barotrauma that is speculated to induce long-term injury. GE, in turn, further increases the already negative intrapulmonary pressure, thereby favoring alveolar collapse (atelectasis). Finally, hypoxia seemingly not only induces brain injury but initiates the opening of intrapulmonary shunts. These pathways are large enough to permit transpulmonary passage of venous N&lt;sub&gt;2&lt;/sub&gt; bubbles, making stroke-like phenomena in deep BH divers possible.
The influence of the FeCp(CO)2+moiety on the dynamics of the metalloid [Ge9(Si(SiMe3)3)3]−cluster in thf: synthesis and characterization by time-resolved absorption spectroscopy
2019-01-01

Photoexcitation of a newly synthesized, neutral tetrasubstituted Ge<sub>9</sub>cluster with a covalently bound transition metal substituent led to a complete ground state recovery within 150 ps indicating the strong influence of the Fe moiety.
High performance passive vibration isolation system for optical tables using six-degree-of-freedom viscous damping combined with steel springs
2019-01-01

Mechanical vibrations in buildings are ubiquitous. Such vibrations limit the performance of sensitive instruments used, for example, for high-precision manufacturing, nanofabrication, metrology, medical systems, or microscopy. For improved precision, instruments and optical tables need to be isolated from mechanical vibrations. However, common active or passive vibration isolation systems often perform poorly when low-frequency vibration isolation is required or are expensive. Furthermore, a simple solution such as suspension from common bungee cords may require high ceilings. Here we developed a vibration isolation system that uses steel springs to suspend an optical table from a common-height ceiling. The system was designed for a fundamental resonance frequency of 0.5 Hz. Resonances and vibrations were efficiently damped in all translational and rotational degrees of freedom of the optical table by spheres, which were mounted underneath the table and immersed in a highly viscous silicone oil. Our low-cost, passive system outperformed several state-of-the-art passive and active systems in particular in the frequency range between 1 and 10 Hz. We attribute this performance to a minimal coupling between the degrees of freedom and the truly three dimensional viscous damping combined with a nonlinear hydrodynamic finite-size effect. Furthermore, the system can be adapted to different loads, resonance frequencies, and dimensions. In the long term, the excellent performance of the system will allow high-precision measurements for many different instruments.
Linking regulatory focus and threat–challenge: transitions between and outcomes of four motivational states
2019-01-01

Self-regulation research has flourished for the last three decades. In social psychology and beyond, a number of motivational approaches have been developed and these have provided new insights about numerous phenomena. However, a theoretical integration of these approaches is lacking, as are empirical comparisons across theories. This article seeks to make a step towards closing this gap. We do so by suggesting a model that specifies the relation between threat and challenge – as defined by the Biopsychosocial Model of arousal regulation – on the one hand, and promotion and prevention focus – as defined by Regulatory Focus Theory – on the other hand. In addition, the literature on the relation between these four motivational states and their impact on (a) the processing of valenced information and (b) the preference for (social) contexts is reviewed. Finally, we identify avenues for further research.
Challenges of Annotating a Code-Switching Treebank
2019-01-01

This paper presents challenges and observations on creating a code-switching treebank based on ongoing annotation efforts of a Turkish-German spoken corpus following the Universal Dependencies annotation scheme.We present and discuss a number of issues that arise because of the need for consistent multilingual annotation within a single treebank, as well as the informal language which is where code-switching is observed most.Besides proposing solutions to these issues, our aim in this paper is to stimulate discussion and facilitate consistency over upcoming code-switching annotation projects.
The Notorious Difficulty of Comparing Human and Machine Perception
2019-01-01

With the rise of machines to human-level performance in complex tasks, a growing amount of work is directed towards comparing information processing in humans and machines. These works have the potential to deepen our understanding of the inner mechanisms of human perception and to improve machine learning. Drawing robust conclusions from comparison studies, however, turns out to be difficult. Here, we highlight common shortcomings that can easily lead to fragile conclusions. First, if a model does achieve high performance on a task similar to humans, its decision-making process is not necessarily human-like. Moreover, further analyses can reveal differences. Second, the performance of neural networks is sensitive to training procedures and architectural details. Thus, generalizing conclusions from specific architectures is difficult. Finally, when comparing humans and machines, equivalent experimental settings are crucial in order to identify innate differences. Addressing these shortcomings alters or refines the conclusions of studies. We show that, despite their ability to solve closed-contour tasks, our neural networks use different decision-making strategies than humans. We further show that there is no fundamental difference between same-different and spatial tasks for common feed-forward neural networks and finally, that neural networks do experience a recognition gap on minimal recognizable images. All in all, care has to be taken to not impose our human systematic bias when comparing human and machine perception.
Circulating tumor cells and their role in prostate cancer
2019-01-01

Circulating tumor cells (CTC) have become an important biomarker in patients with advanced prostate cancer. CTC count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer, a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been observed. Currently, the focus of research is shifting from CTC enumeration towards molecular characterization of CTC leading to the discovery of markers predicting treatment response. The role of androgen receptor splice variants expressed by CTC as markers of resistance to abiraterone and enzalutamide has been assessed by various studies. The identification of CTC markers predicting treatment response represents a key step to guide the selection of treatment (e.g., abiraterone/enzalutamide vs taxanes), particularly in patients with mCRPC. As an alternative to CTC, the analysis of circulating tumor DNA has been shown to enable a noninvasive disease characterization having high potential to promote precision oncology.
GD358: Three Decades of Observations for the In-depth Asteroseismology of a DBV Star
2019-01-01

We report on the analysis of 34 years of photometric observations of the pulsating helium atmosphere white dwarf GD358. The complete data set includes archival data from 1982 to 2006, and 1195.2 hr of new observations from 2007 to 2016. From this data set, we extract 15 frequencies representing g-mode pulsation modes, adding 4 modes to the 11 modes known previously. We present evidence that these 15 modes are l = 1 modes, 13 of which belong to a consecutive sequence in radial overtone k. We perform a detailed asteroseismic analysis using models that include parameterized, complex, carbon and oxygen core composition profiles to fit the periods. Recent spectroscopic analyses place GD358 near the red edge of the DBV instability strip, at 24,000 ± 500 K and a {log} {\\\\\\\\text{}}g of 7.8 ± 0.08 dex. The surface gravity translates to a mass range of 0.455─0.540 {M}ȯ . Our best-fit model has a temperature of 23,650 K and a mass of 0.5706 {M}ȯ . That is slightly more massive than what is suggested by the most recent spectroscopy. We find a pure helium layer mass of 10−5.50, consistent with the result of previous studies and the outward diffusion of helium over time.
Aortic Valve Neocuspidization with Glutaraldehyde-Treated Autologous Pericardium (Ozaki Procedure) – A Promising Surgical Technique
2019-01-01

In cases of aortic valve disease, prosthetic valves have been increasingly used for valve replacement, however, there are inherent problems with prostheses, and their quality in the so-called Third World countries is lower in comparison to new-generation models, which leads to shorter durability. Recently, transcatheter aortic valve replacement has been explored as a less invasive option for patients with high-risk surgical profile. In this scenario, aortic valve neocuspidization (AVNeo) has emerged as another option, which can be applied to a wide spectrum of aortic valve diseases. Despite the promising results, this procedure is not widely spread among cardiac surgeons yet. Spurred on by the last publications, we went on to write an overview of the current practice of state-of-the-art AVNeo and its results.
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
2019-01-01

Cysteine-type cathepsins such as cathepsin B are involved in various steps of inflammatory processes such as antigen processing and angiogenesis. Here, we uncovered the role of cysteine-type cathepsins in the effector phase of T cell-driven cutaneous delayed-type hypersensitivity reactions (DTHR) and the implication of this role on therapeutic cathepsin B-specific inhibition. <b>Methods</b>: Wild-type, cathepsin B-deficient (Ctsb<sup>-/-</sup>) and cathepsin Z-deficient (Ctsz<sup>-/-</sup>) mice were sensitized with 2,4,6-trinitrochlorobenzene (TNCB) on the abdomen and challenged with TNCB on the right ear to induce acute and chronic cutaneous DTHR. The severity of cutaneous DTHR was assessed by evaluating ear swelling responses and histopathology. We performed fluorescence microscopy on tissue from inflamed ears and lymph nodes of wild-type mice, as well as on biopsies from psoriasis patients, focusing on cathepsin B expression by T cells, B cells, macrophages, dendritic cells and NK cells. Cathepsin activity was determined noninvasively by optical imaging employing protease-activated substrate-like probes. Cathepsin expression and activity were validated <i>ex vivo</i> by covalent active site labeling of proteases and Western blotting. <b>Results</b>: Noninvasive <i>in vivo</i> optical imaging revealed strong cysteine-type cathepsin activity in inflamed ears and draining lymph nodes in acute and chronic cutaneous DTHR. In inflamed ears and draining lymph nodes, cathepsin B was expressed by neutrophils, dendritic cells, macrophages, B, T and natural killer (NK) cells. Similar expression patterns were found in psoriatic plaques of patients. The biochemical methods confirmed active cathepsin B in tissues of mice with cutaneous DTHR. Topically applied cathepsin B inhibitors significantly reduced ear swelling in acute but not chronic DTHR. Compared with wild-type mice, Ctsb<sup>-/-</sup> mice exhibited an enhanced ear swelling response during acute DTHR despite a lack of cathepsin B expression. Cathepsin Z, a protease closely related to cathepsin B, revealed compensatory expression in inflamed ears of Ctsb<sup>-/-</sup> mice, while cathepsin B expression was reciprocally elevated in Ctsz<sup>-/-</sup> mice. <b>Conclusion</b>: Cathepsin B is actively involved in the effector phase of acute cutaneous DTHR. Thus, topically applied cathepsin B inhibitors might effectively limit DTHR such as contact dermatitis or psoriasis. However, the cathepsin B and Z knockout mouse experiments suggested a complementary role for these two cysteine-type proteases.
NF-κB signaling and crosstalk during carcinogenesis
2019-01-01

Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex. TFs thus support or suppress the recruitment of the corresponding RNA polymerase. In general, TFs are classified by structure or function. The TF, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), is expressed in all cell types and tissues. NF- κ B signaling and crosstalk are involved in several steps of carcinogenesis including in sequences involving pathogenic stimulus, chronic inflammation, fibrosis, establishment of its remodeling to the precancerous niche (PCN) and transition of a normal cell to a cancer cell. Triggered by various inflammatory cytokines, NF- κ B is activated along with other TFs with subsequent stimulation of cell proliferation and inhibition of apoptosis. The involvement of NF- κ B in carcinogenesis provides an opportunity to develop anti-NF- κ B therapies. The complexity of these interactions requires that we elucidate those aspects of NF- κ B interactions that play a role in carcinogenesis, the sequence of events leading to cancer.
Analyzing Linguistic Complexity and Accuracy in Academic Language Development of German across Elementary and Secondary School
2019-01-01

We track the development of writing complexity and accuracy in German students’ early academic language development from first to eighth grade. Combining an empirically broad approach to linguistic complexity with the high-quality error annotation included in the Karlsruhe Children’s Text corpus (Lavalley et al. 2015) used, we construct models of German academic language development that successfully identify the student’s grade level. We show that classifiers for the early years rely more on accuracy development, whereas development in secondary school is better characterized by increasingly complex language in all domains: linguistic system, language use, and human sentence processing characteristics. We demonstrate the generalizability and robustness of models using such a broad complexity feature set across writing topics.
Could nonhuman great apes also have cultural evolutionary psychology?
2019-01-01

Abstract Attempted answers are given to (a) whether nonhuman great apes (apes) also have evolved imitation (answer: no); (b) whether humans can transmit imitation as a gadget to apes (answer: yes, partly); (c) whether human-to-ape transmission can kickstart subsequent and stable ape cultural evolutionary psychology (“CEP”; answer: unlikely); and (d) when CEP evolved in our lineage (answer: relatively late).
ON TORUS ACTIONS OF HIGHER COMPLEXITY
2019-01-01

We systematically produce algebraic varieties with torus action by constructing them as suitably embedded subvarieties of toric varieties. The resulting varieties admit an explicit treatment in terms of toric geometry and graded ring theory. Our approach extends existing constructions of rational varieties with torus action of complexity one and delivers all Mori dream spaces with torus action. We exhibit the example class of ‘general arrangement varieties’ and obtain classification results in the case of complexity two and Picard number at most two, extending former work in complexity one.
Qualitative Freedom - Autonomy in Cosmopolitan Responsibility
2019-01-01

In the light of growing political and religious fundamentalism, this open access book defends the idea of freedom as paramount for the attempt to find common ethical ground in the age of globality. The book sets out to examine as yet unexhausted ways to boost the resilience of the principle of liberalism. Critically reviewing the last 200 years of the philosophy of freedom, it revises the principle of liberty in order to revive it. It discusses many different aspects that fall under its three main topics: the metaphysics of freedom, quantitative freedom and qualitative freedom. Open societies worldwide have come under increasing pressure in the last decades. The belief that politics and markets fare best when guided by the principle of liberty presently faces multiple challenges such as terrorism, climate warming, inequality, populism, and financial crises. In the view of its critics, the idea of freedom no longer offers adequate guidance to meet these challenges and should be partially corrected or even entirely replaced by countervailing values. Against the reduction of freedom to the merely quantitative question as to how much liberties individuals call their own, this book draws attention to the qualitative concerns which and whose opportunities society should foster. It argues that, correctly understood, the idea of liberty commits us to defend as well as advance the freedom of each and every world citizen.