julilili42/papers huggingface dataset:
Surface Free Energy of a Hard-Disk Fluid at Curved Hard Walls: Theory and Simulation
2020-06-26

In this work, we examine the surface thermodynamics of a hard-disk fluid at curved hard walls using Monte Carlo (MC) simulation and a generalized scaled particle theory (gSPT). The curved walls are modeled as hard disks of varying radii, <i>R</i>. The surface free energy, γ, and excess surface volume, <i>v</i><sub>ex</sub>, for this system are calculated as functions of both the fluid packing fraction and the wall radius. The simulation results are used to test, for this system, the assumptions of morphometric thermodynamics (MT), which predicts that both γ and <i>v</i><sub>ex</sub> are linear functions of the surface curvature, 1/<i>R</i>, for a two-dimensional system. In addition, we compare the simulation results to the gSPT developed in this work, as well as with virial expansions derived from the known virial coefficients of the binary hard-sphere fluid. At low to intermediate packing fractions, the non-MT terms (terms of higher order than 1/<i>R</i> in a expansion of γ and <i>v</i><sub>ex</sub>) of γ are zero within the simulation error; however, at the highest densities, deviations from MT become significant, similar to what was seen in our earlier simulation work on the three-dimensional hard-sphere/hard-wall system. In addition, the new gSPT gives improved results for both γ and <i>v</i><sub>ex</sub> over standard scaled particle theory (SPT) but underestimates the deviations from MT at high density.
Role of Multiparametric Magnetic Resonance Imaging in Predicting Pathologic Outcomes in Prostate Cancer
2020-06-26

Multiparametric magnetic resonance imaging (mpMRI) and the introduction of standardized protocols for its interpretation have had a significant impact on the field of prostate cancer (PC). Multiple randomized controlled trials have shown that the sensitivity for detection of clinically significant PC is increased when mpMRI results are the basis for indication of a prostate biopsy. The added value with regards to sensitivity has been strongest for patients with persistent suspicion for PC after a prior negative biopsy. Although enhanced sensitivity of mpMRI is convincing, studies that have compared mpMRI with prostatectomy specimens prepared by whole-mount section analysis have shown a significant number of lesions that were not detected by mpMRI. In this context, the importance of an additional systematic biopsy (SB) is still being debated. While SB in combination with targeted biopsies leads to an increased detection rate, most of the tumors detected by SB only are considered clinically insignificant. Currently, multiple risk calculation tools are being developed that include not only clinical parameters but mpMRI results in addition to clinical parameters in order to improve risk stratification for PC, such as the Partin tables. In summary, mpMRI of the prostate has become a standard procedure recommended by multiple important guidelines for the diagnostic work-up of patients with suspicion of PC.
The quandary of diagnosing mathematical difficulties in a generally low performing population
2020-06-26

Brazilian students’ mathematical achievement was repeatedly observed to fall below average levels ofmathematical attainment in international comparison studies such as PISA. In this article, we argue thatthis general low level of mathematical attainment interferes with the diagnosis of developmentaldyscalculia when the psychometric criterion is used: establishing of an arbitrary cut-off (e.g., performance&amp;lt; percentile 10) may lead to misleading diagnoses. Therefore, the present study set off to evaluate theperformance of Brazilian school children on basic arithmetic operations. Seven hundred and six childrenfrom 3rd to 5th grades completed a calculation task assessing arithmetic fluency in addition, subtraction,and multiplication. In line with PISA results, children presented difficulties in all arithmetic operationsinvestigated. Children performed better in addition than subtraction and multiplication, and 3rd and 4thgraders were outperformed by 5th graders in all three operations. However, even after five years offormal schooling, less than half of 5th graders performed perfectly on simple addition, subtraction, andmultiplication problems. Therefore, these data substantiate the argument that the sole use of apsychometric criterion might not be sensible to diagnose dyscalculia in the context of a generally lowperforming population, such as Brazilian primary school children. When the majority of children failthe task, it is hard to distinguish atypical from typical numerical development. As such, other diagnosticapproaches, such as Response to Intervention, might be more suitable in such a context.
Outcomes with Ventricular Assist Device Therapy for Advanced Heart Failure in North Macedonia: First Annual Report
2020-06-26

Introduction: Mechanical circulatory support by a continuous-flow ventricular assist device (VAD) improves survival and quality of life in selected patients with advanced heart failure. Developing countries have been struggling to construct a contemporary and effective health care system to manage advanced heart failure. This observation represents the first annual report on clinical outcomes with VAD for patients with advanced heart failure in the Republic of North Macedonia. Methods: Data from all patients with VAD implantations between November 2018 and December 2019 were collected. The etiology of the heart failure was dilated cardiomyopathy in 4 patients (57%), ischemic cardiomyopathy in 2 (28%), and hypertrophic cardiomyopathy in 1 (14%). The primary outcome was survival; secondary outcomes included adverse events defined according to the Interagency Registry for Mechanically Assisted Circulatory Support. Results: A total of 7 patients (85% males, median age 56 years) received a VAD; 5 of them received left VAD, and the remaining 2 received biventricular VAD. There were no deaths. Observed morbidity during a mean follow-up of 216 days included 3 bleeding events in 1 patient, 2 patients with superficial driveline infection, and 1 minor stroke and a pump thrombosis, which were treated with VAD exchange. Significant improvement in quality of life, as assessed by the Kansas City Cardiomyopathy Questionnaire and the Functional Independence MeasureTM instrument, was seen with all patients. Conclusions: Our results demonstrate a successful initiation of the VAD program in the Republic of North Macedonia. Proper training of a dedicated HF team supports the reproducibility of this treatment in developing countries.
Altering identities. Possibilities of understanding identity in phenomenological pedagogy
2020-06-26

&#x0D; &#x0D; &#x0D; In one way or another, the other plays an important role in educational settings. Over the last few decades, the recourse to philosophical phenomenology has proved to be helpful for the discussion of this topic. Coming from this thematic direction, this article focuses on the other in its constitutive function for the construction of identity. Both within the phenomenologist Bernhard Waldenfels’ theory of responsivity as well as in the pedagogue Wilfried Lippitz’ theory of alterity, the other is a structural part of the self. It will be shown that within these theories the possible dangers of an encounter with the other cannot be addressed in an adequate way. However, this is especially important in educational contexts. Therefore, with regard to the philosophies of Jean‐Paul Sartre and Simone de Beauvoir, I would like to present two additional phenomenological approaches from which the pedagogical discussion can benefit. Both Sartre and Beauvoir put great focus on possible obstacles regarding the en‐ counter with the other. Whereas Sartre identifies negativity as an essential part of human existence, Beauvoir enriches these thoughts with an ethical component. Against the background of these philosophies, the other comes into view as a possible source of both objectification and empowerment. Lastly, the article shows that an implementation of these considerations in teacher training can lead to a deeper understanding of the constitution of identity and the inherent possibilities of any interaction with the other.&#x0D; &#x0D; &#x0D;
Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms
2020-06-26

Abstract Background: Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic sites. Due to often slow growth rates and (in most cases) endocrine non-functionality, NETs are often detected only in a progressed metastatic situation, where therapy options are still severely limited. So far, immunotherapies and especially immunovirotherapies are not established as novel treatment modalities for NETs. Methods: In this immunovirotherapy study, pancreatic NET (BON-1, QGP-1), lung NET (H727, UMC-11), as well as neuroendocrine carcinoma (NEC) cell lines (HROC-57, NEC-DUE1) were employed. The well characterized genetically engineered vaccinia virus GLV-1h68, which has already been investigated in various clinical trials, was chosen as virotherapeutical treatment modality. Results: Profound oncolytic efficiencies were found for NET/NEC tumor cells. Besides, NET/NEC tumor cell bound expression of GLV-1h68-encoded marker genes was observed also. Furthermore, a highly efficient production of viral progenies was detected by sequential virus quantifications. Moreover, the mTOR inhibitor everolimus, licensed for treatment of metastatic NETs, was not found to interfere with GLV-1h68 replication, making a combinatorial treatment of both feasible. Conclusions: In summary, the oncolytic vaccinia virus GLV-1h68 was found to exhibit promising antitumoral activities, replication capacities and a potential for future combinatorial approaches in cell lines originating from neuroendocrine neoplasms. Based on these preliminary findings, virotherapeutic effects now have to be further evaluated in animal models for treatment of Neuroendocrine neoplasms (NENs).
A Probabilistic Assessment of Soil Erosion Susceptibility in a Head Catchment of the Jemma Basin, Ethiopian Highlands
2020-06-27

Soil erosion represents one of the most important global issues with serious effects on agriculture and water quality, especially in developing countries, such as Ethiopia, where rapid population growth and climatic changes affect widely mountainous areas. The Meskay catchment is a head catchment of the Jemma Basin draining into the Blue Nile (Central Ethiopia) and is characterized by high relief energy. Thus, it is exposed to high degradation dynamics, especially in the lower parts of the catchment. In this study, we aim at the geomorphological assessment of soil erosion susceptibilities. First, a geomorphological map was generated based on remote sensing observations. In particular, we mapped three categories of landforms related to (i) sheet erosion, (ii) gully erosion, and (iii) badlands using a high-resolution digital elevation model (DEM). The map was validated by a detailed field survey. Subsequently, we used the three categories as dependent variables in a probabilistic modelling approach to derive the spatial distribution of the specific process susceptibilities. In this study we applied the maximum entropy model (MaxEnt). The independent variables were derived from a set of spatial attributes describing the lithology, terrain, and land cover based on remote sensing data and DEMs. As a result, we produced three separate susceptibility maps for sheet and gully erosion as well as badlands. The resulting susceptibility maps showed good to excellent prediction performance. Moreover, to explore the mutual overlap of the three susceptibility maps, we generated a combined map as a color composite where each color represents one component of water erosion. The latter map yields useful information for land-use managers and planning purposes.
New insight into the origin of the GeV flare in the binary system PSR B1259-63/LS 2883 from the 2017 periastron passage
2020-06-27

ABSTRACT PSR B1259-63 is a gamma-ray binary system hosting a radio pulsar orbiting around an O9.5Ve star, LS 2883, with a period of ∼3.4 yr. The interaction of the pulsar wind with the LS 2883 outflow leads to unpulsed broad-band emission in the radio, X-rays, GeV, and TeV domains. While the radio, X-ray, and TeV light curves show rather similar behaviour, the GeV light curve appears very different with a huge outburst about a month after a periastron. The energy release during this outburst seems to significantly exceed the spin-down luminosity of the pulsar and both the GeV light curve and the energy release vary from one orbit to the next. In this paper, we present for the first time the results of optical observations of the system in 2017, and also reanalyse the available X-ray and GeV data. We present a new model in which the GeV data are explained as a combination of the bremsstrahlung and inverse Compton emission from the unshocked and weakly shocked electrons of the pulsar wind. The X-ray and TeV emission is produced by synchrotron and inverse Compton emission of energetic electrons accelerated on a strong shock arising due to stellar/pulsar winds collision. The brightness of the GeV flare is explained in our model as a beaming effect of the energy released in a cone oriented, during the time of the flare, in the direction of the observer.
Fracturing and Porosity Channeling in Fluid Overpressure Zones in the Shallow Earth’s Crust
2020-06-27

At the time of energy transition, it is important to be able to predict the effects of fluid overpressures in different geological scenarios as these can lead to the development of hydrofractures and dilating high-porosity zones. In order to develop an understanding of the complexity of the resulting effective stress fields, fracture and failure patterns, and potential fluid drainage, we study the process with a dynamic hydromechanical numerical model. The model simulates the evolution of fluid pressure buildup, fracturing, and the dynamic interaction between solid and fluid. Three different scenarios are explored: fluid pressure buildup in a sedimentary basin, in a vertical zone, and in a horizontal layer that may be partly offset by a fault. Our results show that the geometry of the area where fluid pressure is successively increased has a first-order control on the developing pattern of porosity changes, on fracturing, and on the absolute fluid pressures that sustained without failure. If the fluid overpressure develops in the whole model, the effective differential and mean stress approach zero and the vertical and horizontal effective principal stresses flip in orientation. The resulting fractures develop under high lithostatic fluid overpressure and are aligned semihorizontally, and consequently, a hydraulic breccia forms. If the area of high fluid pressure buildup is confined in a vertical zone, the effective mean stress decreases while the differential stress remains almost constant and failure takes place in extensional and shear modes at a much lower fluid overpressure. A horizontal fluid pressurized layer that is offset shows a complex system of effective stress evolution with the layer fracturing initially at the location of the offset followed by hydraulic breccia development within the layer. All simulations show a phase transition in the porosity where an initially random porosity reduces its symmetry and forms a static porosity wave with an internal dilating zone and the presence of dynamic porosity channels within this zone. Our results show that patterns of fractures, hence fluid release, that form due to high fluid overpressures can only be successfully predicted if the geometry of the geological system is known, including the fluid overpressure source and the position of seals and faults that offset source layers and seals.
Spontaneous (minimal) ritual in non-human great apes?
2020-06-28

The potential for rituals in non-human great apes (apes) is an understudied topic. We derive a minimal definition of ritual and then examine the currently available evidence for it in untrained and non-enculturated apes. First, we examine whether such apes show evidence for the two main components of our minimal definition of ritual: symbolism and copying. Second, we examine if there are actual cases already identifiable today that may fit all aspects of our minimal definition of ritual—or whether there are at least cases that fit some aspects (proto-ritual). We find that apes are not likely to spontaneously practise minimal ritual, but we claim that the highest expected likelihood of occurrence is in the results-copying domain. Yet, we did not find actual cases of minimal ritual in apes—including those involving environmental results. We did, however, find some cases that may match at least part of our minimal ritual definition—which we termed proto-ritual. At least two out of three potential cases of such proto-rituals that we identified (rain dance, object-in-ear and surplus nest-making procedures) do revolve around results. Overall, apes do not show much, or very clear, evidence for even minimal ritual, but may sometimes show proto-ritual. However, dedicated ape ritual studies are currently lacking, and future work may identify ape ritual (or clearer cases of proto-ritual). We discuss the implications of our preliminary finding for inferences of ritual in the last common ancestor of humans and apes. This article is part of the theme issue ‘Ritual renaissance: new insights into the most human of behaviours’.
Fast 3D imaging of giant unilamellar vesicles using reflected light-sheet microscopy with single molecule sensitivity
2020-06-28

Abstract Observation of highly dynamic processes inside living cells at the single molecule level is key for a quantitative understanding of biological systems. However, imaging of single molecules in living cells usually is limited by the spatial and temporal resolution, photobleaching and the signal-to-background ratio. To overcome these limitations, light-sheet microscopes with thin selective plane illumination have recently been developed. For example, a reflected light-sheet design combines the illumination by a thin light-sheet with a high numerical aperture objective for single-molecule detection. Here, we developed a reflected light-sheet microscope with active optics for fast, high contrast, two-color acquisition of z -stacks. We demonstrate fast volume scanning by imaging a two-color giant unilamellar vesicle (GUV) hemisphere. In addition, the high signal-to-noise ratio enabled the imaging and tracking of single lipids in the cap of a GUV. In the long term, the enhanced reflected scanning light sheet microscope enables fast 3D scanning of artificial membrane systems and cells with single-molecule sensitivity and thereby will provide quantitative and molecular insight into the operation of cells.
Absence of Severe Acute Respiratory Syndrome-Coronavirus-2 RNA in Human Corneal Tissues
2020-06-29

Purpose: To examine corneal tissue for severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) positivity regarding implications for tissue procurement, processing, corneal transplantation, and ocular surgery on healthy patients. We performed quantitative reverse transcription-polymerase chain reaction qRT-PCR-testing for SARS-CoV-2 RNA on corneal stroma and endothelium, bulbar conjunctiva, conjunctival fluid swabs, anterior chamber fluid, and corneal epithelium of coronavirus disease 2019 (COVID-19) postmortem donors. Methods: Included in this study were 10 bulbi of 5 COVID-19 patients who died because of respiratory insufficiency. Informed consent and institutional review board approval was obtained before this study (241/2020BO2). SARS-CoV-2 was detected by using a pharyngeal swab and bronchoalveolar lavage. Tissue procurement and tissue preparation were performed with personal protective equipment (PPE) and the necessary protective measures. qRT-PCR-testing was performed for each of the abovementioned tissues and intraocular fluids. Results: The qRT-PCRs yielded no viral RNA in the following ocular tissues and intraocular fluid: corneal stroma and endothelium, bulbar-limbal conjunctiva, conjunctival fluid swabs, anterior chamber fluid, and corneal epithelium. Conclusions: In this study, no SARS-CoV-2-RNA was detected in conjunctiva, anterior chamber fluid, and corneal tissues (endothelium, stroma, and epithelium) of COVID-19 donors. This implicates that the risk for SARS-CoV-2 infection using corneal or conjunctival tissue is very low. However, further studies on a higher number of COVID-19 patients are necessary to confirm these results. This might be of high importance for donor tissue procurement, processing, and corneal transplantation.
Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
2020-06-29

Acyldepsipeptide (ADEP) antibiotics effectively kill multidrug-resistant Gram-positive pathogens, including vancomycin-resistant enterococcus, penicillin-resistant Streptococcus pneumoniae (PRSP), and methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity of ADEP depends on a new mechanism of action, i.e., the deregulation of bacterial protease ClpP that leads to bacterial self-digestion. Our data allow new insights into the mode of ADEP action by providing a molecular explanation for the distinct bacterial phenotypes observed at low versus high ADEP concentrations. In addition, we show that ClpP alone, in the absence of any unfoldase or energy-consuming system, and only activated by the small molecule antibiotic ADEP, leads to the unfolding of the cell division protein FtsZ.
Biochar as electron donor for reduction of N2O by Paracoccus denitrificans
2020-06-29

ABSTRACT Biochar (BC) has been shown to influence microbial denitrification and mitigate soil N2O emissions. However, it is unclear if BC is able to directly stimulate the microbial reduction of N2O to N2. We hypothesized that the ability of BC to lower N2O emissions could be related not only to its ability to store electrons, but to donate them to bacteria that enzymatically reduce N2O. Therefore, we carried out anoxic incubations with Paracoccus denitrificans, known amounts of N2O, and nine contrasting BCs, in the absence of any other electron donor or acceptor. We found a strong and direct correlation between the extent and rates of N2O reduction with BC's EDC/EEC (electron donating capacity/electron exchange capacity). Apart from the redox capacity, other BC properties were found to regulate the BC's ability to increase N2O reduction by P. denitrificans. For this specific BC series, we found that a high H/C and ash content, low surface area and poor lignin feedstocks favored N2O reduction. This provides valuable information for producing tailored BCs with the potential to assist and promote the reduction of N2O in the pursuit of reducing this greenhouse gas emissions.