julilili42/papers huggingface dataset:
The corona of a fully convective star with a near-polar flare
2023-09-13

&amp;lt;p&amp;gt;Raw XMM-Newton EPIC data, data reduction scripts for XMM-SAS, and reduced images and spectra extracted with XSPEC. The observations include the X-ray emission of TIC 277539431, a rapidly rotating M7 dwarf star that produced a polar flare in 2021, observed by the Transiting Exoplanet Survey Satellite (see &amp;lt;a href="https://ui.adsabs.harvard.edu/abs/2021MNRAS.507.1723I"&amp;gt;Ilin et al. 2021&amp;lt;/a&amp;gt;).&amp;lt;br&amp;gt;\\n&amp;lt;br&amp;gt;\\nPublications based on this data set will be linked as they appear.&amp;lt;/p&amp;gt;
The corona of a fully convective star with a near-polar flare
2023-09-13

Raw XMM-Newton EPIC data, data reduction scripts for XMM-SAS, and reduced images and spectra extracted with XSPEC. The observations include the X-ray emission of TIC 277539431, a rapidly rotating M7 dwarf star that produced a polar flare in 2021, observed by the Transiting Exoplanet Survey Satellite (see Ilin et al. 2021). Publications based on this data set will be linked as they appear.
Long-Term Survivors after Failure of Chimeric Antigen Receptor T Cell Therapy for Large B Cell Lymphoma: A Role for Allogeneic Hematopoietic Cell Transplantation? A German Lymphoma Alliance and German Registry for Stem Cell Transplantation Analysis
2023-09-14

The outcome of patients with large B cell lymphoma (LBCL) who relapse or progress after CD19-directed chimeric antigen receptor T cell therapy (CAR-T) administered as salvage therapy beyond the second treatment line is poor. However, a minority of patients become long-term survivors despite CAR-T failure. The German Lymphoma Alliance (GLA) has proposed a hierarchical management algorithm for CAR-T failure in LBCL, aimed at allogeneic hematopoietic cell transplantation (alloHCT) as definite therapy in eligible patients. The purpose of this study was to investigate characteristics, relapse patterns, and management strategies in long-term survivors after CAR-T failure, with a particular focus on the feasibility and outcome of alloHCT. This was a retrospective analysis of all evaluable patients with a relapse/progression event (REL) observed in a previously reported GLA sample between November 2018 and May 2021. REL occurred in 214 of 356 patients (60%) who underwent CAR-T for LBCL in the previous GLA study. An evaluable dataset was available for 143 of these 214 patients (67%). Twenty-six of 143 patients (18%) survived 12 months or longer from REL, 109 (76%) died within the first year after REL, and 8 (6%) were alive but had not reached the 12-month landmark. Long-term survivors had more favorable pre-CAR-T features, had a longer interval between CAR-T and REL, and had more often received a tumor biopsy after CAR-T failure, whereas the choice of the first salvage regimen had no impact. AlloHCT was feasible in 40 of 53 patients (75%) intended and resulted in a 12-month post-transplantation overall survival of 36% in those patients who underwent transplantation with sensitive or untreated REL. AlloHCT after CAR-T failure in LBCL is feasible and may be an important contributor to long-term survival, although selection bias must be taken into account. Thus, alloHCT should be considered as a reasonable treatment option for eligible patients in this setting. However, because the overall outlook after CAR-T failure remains poor, novel effective therapeutic approaches are needed, either to allow long-term disease control per se or to improve the preconditions for successful alloHCT.
Resting state EEG as biomarker of cognitive training and physical activity’s joint effect in Parkinson’s patients with mild cognitive impairment
2023-09-14

Abstract Background Cognitive decline is a major factor for the deterioration of the quality of life in patients suffering from Parkinson’s disease (PD). Recently, it was reported that cognitive training (CT) in PD patients with mild cognitive impairment (PD-MCI) led to an increase of physical activity (PA) accompanied by improved executive function (EF). Moreover, PA has been shown to alter positively brain function and cognitive abilities in PD. Both observations suggest an interaction between CT and PA. Objectives A previous multicenter (MC) study was slightly significant when considering independent effects of interventions (CT and PA) on EF. Here, we use MC constituent single center data that showed no effect of interventions on EF. Thus, this exploratory study considers pooling data from both interventions to gain insight into a recently reported interaction between CT and PA and provide a proof of principle for the usefulness of resting state EEG as a neurophysiological biomarker of joint intervention’s effect on EF and attention in PD-MCI. Methods Pre- and post-intervention resting state EEG and neuropsychological scores (EF and attention) were obtained from 19 PD-MCI patients (10 (CT) and 9 (PA)). We focused our EEG analysis on frontal cortical areas due to their relevance on cognitive function. Results We found a significant joint effect of interventions on EF and a trend on attention, as well as trends for the negative correlation between attention and theta power (pre), the positive correlation between EF and alpha power (post) and a significant negative relationship between attention and theta power over time (post-pre). Conclusions Our results support the role of theta and alpha power at frontal areas as a biomarker for the therapeutic joint effect of interventions.
Beliefs about emotions predict psychological stress related to somatic symptoms
2023-09-14

Abstract Background Previous research has shown that the more people believe their emotions are controllable and useful (BECU), the less they generally report psychological distress. Psychological distress, in turn, impacts health outcomes, and is among the most frequently reported complaints in psychotherapeutic and psychosomatic practice. Objective We aimed to examine how BECU predicts psychological distress related to somatic symptoms in a prospective sample from the general population and to replicate this association in two cross‐sectional samples of psychosomatic patients. Methods We applied a panel design with an interval of 2 weeks between T1 and T2 in general‐population panel‐participants ( N = 310), assessing BECU and psychological distress related to somatic symptoms via validated self‐report measures. Moreover, we cross‐sectionally replicated the relationship between BECU and psychological distress in a clinical sample of psychosomatic outpatients diagnosed with somatoform disorders ( n = 101) or without somatoform disorders ( n = 628). Results BECU predicted over and above the lagged criterion panel‐participants' psychological distress related to somatic symptoms, β = −.18, p &lt; .001. BECU was also cross‐sectionally related to psychological distress in our clinical replication‐sample of psychosomatic outpatients diagnosed with somatoform disorders, r S (87) = −.33, p = .002 and in those without, r S (557) = ‐.21, p &lt; .001. Conclusions BECU as a malleable way of thinking about emotions predicted psychological distress related to somatic symptoms in general‐population panel‐participants and correlated with the same in two clinical replication samples. BECU thus becomes a promising treatment target in psychotherapeutic approaches.
A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans
2023-09-14

During aging, proteostasis capacity declines and distinct proteins become unstable and can accumulate as protein aggregates inside and outside of cells. Both in disease and during aging, proteins selectively aggregate in certain tissues and not others. Yet, tissue-specific regulation of cytoplasmic protein aggregation remains poorly understood. Surprisingly, we found that the inhibition of 3 core protein quality control systems, namely chaperones, the proteasome, and macroautophagy, leads to lower levels of age-dependent protein aggregation in Caenorhabditis elegans pharyngeal muscles, but higher levels in body-wall muscles. We describe a novel safety mechanism that selectively targets newly synthesized proteins to suppress their aggregation and associated proteotoxicity. The safety mechanism relies on macroautophagy-independent lysosomal degradation and involves several previously uncharacterized components of the intracellular pathogen response (IPR). We propose that this protective mechanism engages an anti-aggregation machinery targeting aggregating proteins for lysosomal degradation.
A Likelihood Ratio Approach for Utilizing Case-Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2
2023-09-14

A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analysis of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC) and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity—findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared with classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and preformatted Excel calculators for implementation of the method for rare variants in BRCA1, BRCA2, and other high-risk genes with known penetrance.
Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection
2023-09-14

Plant viruses represent a risk to agricultural production and as only a few treatments exist, it is urgent to identify resistance mechanisms and factors. In plant immunity, plasma membrane (PM)-localized proteins play an essential role in sensing the extracellular threat presented by bacteria, fungi, or herbivores. Viruses are intracellular pathogens and as such the role of the plant PM in detection and resistance against viruses is often overlooked. We investigated the role of the partially PM-bound Calcium-dependent protein kinase 3 (CPK3) in viral infection and we discovered that it displayed a specific ability to hamper viral propagation over CPK isoforms that are involved in immune response to extracellular pathogens. More and more evidence supports that the lateral organization of PM proteins and lipids underlies signal transduction in plants. We showed here that CPK3 diffusion in the PM is reduced upon activation as well as upon viral infection and that such immobilization depended on its substrate, Remorin (REM1.2), a scaffold protein. Furthermore, we discovered that the viral infection induced a CPK3-dependent increase of REM1.2 PM diffusion. Such interdependence was also observable regarding viral propagation. This study unveils a complex relationship between a kinase and its substrate that contrasts with the commonly described co-stabilisation upon activation while it proposes a PM-based mechanism involved in decreased sensitivity to viral infection in plants.
Testing different function fitting methods for mobile eye-tracker calibration
2023-09-14

During calibration, an eye-tracker fits a mapping function from features to a target gaze point. While there is research on which mapping function to use, little is known about how to best estimate the function's parameters. We investigate how different fitting methods impact accuracy under different noise factors, such as mobile eye-tracker imprecision or detection errors in feature extraction during calibration. For this purpose, a simulation of binocular gaze was developed for a) different calibration patterns and b) different noise characteristics. We found the commonly used polynomial regression via least-squares-error fit often lacks to find good mapping functions when compared to ridge regression. Especially as data becomes noisier, outlier-tolerant fitting methods are of importance. We demonstrate a reduction in mean MSE of 20% by simply using ridge over polynomial fit in a mobile eye-tracking experiment.
Interdependence of a kinase and its cognate substrate plasma membrane nanoscale dynamics underlies Arabidopsis response to viral infection
2023-09-14

Abstract Plant viruses represent a risk to agricultural production and as only few treatments exist, it is urgent to identify resistance mechanisms and factors. In plant immunity, plasma membrane (PM)-localized proteins are playing an essential role in sensing the extracellular threat presented by bacteria, fungi or herbivores. Viruses being intracellular pathogens, the role of the plant PM in detection and resistance against viruses is often overlooked. We investigated the role of the partially PM-bound Calcium-dependent protein kinase 3 (CPK3) in viral infection and we discovered that it displayed a specific ability to hamper viral propagation over CPK isoforms that are involved in immune response to extracellular pathogens. More and more evidence support that the lateral organization of PM proteins and lipids underlies signal transduction in plants. We showed here that CPK3 diffusion in the PM is reduced upon activation as well as upon viral infection and that such immobilization depended on its substrate, Remorin (REM1.2), a scaffold protein. Furthermore, we discovered that the viral infection induced a CPK3-dependent increase of REM1.2 PM diffusion. Such interdependence was also observable regarding viral propagation. This study unveils a complex relationship between a kinase and its substrate that contrasts with the commonly described co-stabilisation upon activation while it proposes a PM-based mechanism involved in decreased sensitivity to viral infection in plants.
First Millennium Urbanism in Central Asia: Typology and Evolution of Dzhety-asar Settlements
2023-09-14

Abstract Despite its apparent size and length of its existence, the Dzhety-asar culture of Kazakhstan remains one of the great unknowns of Central Asian archaeology, comprising, as it did, several dozen now-ruined settlements with an almost thousand-year long occupational history. First settled around the 1st century BC and gradually abandoned in the second half of the 1st millennium AD , the Dzhety-asar towns and manors were located to the east of the Aral Sea within the Syr Darya delta, and may have functioned as a core element in Central Asia’s medieval trade networks. Despite past research efforts by the Khorezmian Archaeological Ethnographic Expedition (KhAEE), the cultural and political history of the Dzhety-asar people remains largely unclear, with as yet no consensus on the political structure or their ethnic, linguistic and religious make-up. The present paper does not presume to answer these questions at this stage, as it is the result of two fieldwork seasons documenting and surveying Dzhety-asar settlements. It is, instead, intended to lay out the preliminary findings, presenting a revised typology of sites, and suggest initial hypotheses regarding the structure and possible evolution of the culture.
ChatGPT in education: global reactions to AI innovations
2023-09-15

Abstract The release and rapid diffusion of ChatGPT have caught the attention of educators worldwide. Some educators are enthusiastic about its potential to support learning. Others are concerned about how it might circumvent learning opportunities or contribute to misinformation. To better understand reactions about ChatGPT concerning education, we analyzed Twitter data (16,830,997 tweets from 5,541,457 users). Based on topic modeling and sentiment analysis, we provide an overview of global perceptions and reactions to ChatGPT regarding education. ChatGPT triggered a massive response on Twitter, with education being the most tweeted content topic. Topics ranged from specific (e.g., cheating) to broad (e.g., opportunities), which were discussed with mixed sentiment. We traced that authority decisions may influence public opinions. We discussed that the average reaction on Twitter (e.g., using ChatGPT to cheat in exams) differs from discussions in which education and teaching–learning researchers are likely to be more interested (e.g., ChatGPT as an intelligent learning partner). This study provides insights into people's reactions when new groundbreaking technology is released and implications for scientific and policy communication in rapidly changing circumstances.
Individual differences in information demand have a low dimensional structure predicted by some curiosity traits
2023-09-15

To understand human learning and progress, it is crucial to understand curiosity. But how consistent is curiosity’s conception and assessment across scientific research disciplines? We present the results of a large collaborative project assessing the correspondence between curiosity measures in personality psychology and cognitive science. 820 participants completed 15 personality trait measures and 9 cognitive tasks that tested multiple aspects of information demand. We show that shared variance across the cognitive tasks was captured by a dimension reflecting directed (uncertainty-driven) versus random (stochasticity-driven) exploration and individual differences along this axis were significantly and consistently predicted by personality traits. However, the personality metrics that best predicted information demand were not the central curiosity traits of openness to experience, deprivation sensitivity, and joyous exploration, but instead included more peripheral curiosity traits (need for cognition, thrill seeking, and stress tolerance) and measures not traditionally associated with curiosity (extraversion and behavioral inhibition). The results suggest that the umbrella term “curiosity” reflects a constellation of cognitive and emotional processes, only some of which are shared between personality measures and cognitive tasks. The results reflect the distinct methods that are used in these fields, indicating a need for caution in comparing results across fields and for future interdisciplinary collaborations to strengthen our emerging understanding of curiosity.
Enriching a randomized controlled treatment trial for anorexia nervosa by lived experience—Chances and effects of a lived experience council in the SUSTAIN study
2023-09-15

Abstract Background The development and advancement of treatment and care options is one priority in the field of eating disorders. The inclusion of persons with lived experience with eating disorders into clinical research could enrich and accelerate this endeavor, as they can add different perspectives on the disease and its treatment. Although lived experience perspectives are increasingly part of eating disorder research, they have not been widely or structurally implemented into clinical trials and there is limited information on the practice of participatory research, its framework and consequences. Aims The present work outlines the participatory collaboration with a lived experience council in the randomized controlled treatment trial SUSTAIN. Materials &amp; Methods The manuscript is a participatory publication co‐written by individuals with lived experience with anorexia nervosa and eating disorder researchers. Results We report on motivations for this approach, our collaboration principles, structures and shared experience of working together in the trial, the potential burdens and benefits related to participation for people with lived experience. Discussion We outline future directions and perspectives to integrate a participatory framework into clinical eating disorder research. Conclusion The involvement of people with experiential knowledge is complex, but possible in clinical research on ED and bears huge potential for the development of more effective care. Public Significance Incorporating perspectives of people with lived experience into a participatory framework of mental health research bears huge potential on a societal level. This includes more relevant research topics and designs, more tailored and effective interventions, and facilitated implementation, as well as dissemination, higher credibility, destigmatization of mental illness, and patient empowerment. Participatory clinical research, however, needs structural anchorage within science and society.
Spotting ethylene in forest soils—What influences the occurrence of the phytohormone?
2023-09-15

Abstract Due to the rapid microbial degradation, ethylene (ethene; C 2 H 4 ) detection in most soils is difficult. The knowledge about factors favoring the occurrence of C 2 H 4 is mainly based on laboratory experiments which are not necessarily representative for real field conditions in forest soils. We report results from a total of 24 measuring plots in southwest Germany and more than 50,000 gas samples, including long-term forest monitoring sites and other study sites involving liming, artificial soil compaction, and temporary waterlogging. Many of the patterns and influencing factors identified in the laboratory were confirmed. In well-aerated forest soils, C 2 H 4 was detected in 1.3% of the gas samples. C 2 H 4 detection was higher at oxygen (O 2 ) concentrations below 10% in the soil. The effect was positively correlated with bulk density in compacted soils and CO 2 , CH 4 , and N 2 O concentrations—factors that indicate reduced microbial activity and thus also facilitate the detection of C 2 H 4 . It could be detected 3.5 times more often in spruce than in beech stands, indicating that plant species plays a role and was not found to follow any distinct spatial or temporal pattern with the exception of seemingly random spatio-temporal clusters of root-born C 2 H 4 near large roots of spruce trees. The long observation period and large dataset of this field study allowed valuable insights into C 2 H 4 occurrence in forest soils under natural conditions supporting the theory that the plant hormone C 2 H 4 is produced as a warning for anaerobic soil areas that are limiting root growth.
Information intervention on long-term earnings prospects and the gender gap in major choice
2023-09-15

Abstract This study investigates whether an intervention that provided high school seniors with information on costs and economic returns to tertiary education and on the long-term earnings prospects of college graduates from different study fields enhances the probability that male and female students opt for financially more rewarding study fields and for business-related or STEM fields with a lower share of women. It extends our understanding on the potentials of information interventions for reducing gender segregation in tertiary education. We draw on a field experiment in one German federal state, Berlin, which included a randomized information intervention, and analyse longitudinal data from 1,036 students in schools with a high share of less privileged students. Our results show that a short and low-cost information intervention on costs and returns to college education, including returns in different fields of study, can substantially reduce women’s enrolment in care/social subjects, increase their enrolment in other, non-technical fields while also increasing men’s enrolment in technical fields with above-average earnings. The overall effects appear limited in challenging the gender-typicality of enrolment choices, as students tend to choose more profitable majors while avoiding gender-atypical fields.