julilili42/papers huggingface dataset:
The strength of soil-plant interactions under forest is related to a Critical Soil Depth
2019-06-14

Abstract Soil properties and terrain attributes are of great interest to explain and model plant productivity and community assembly (hereafter P&amp;CA). Many studies only sample surface soils, and may therefore miss important variation of deeper soil levels. We aimed to identify a critical soil depth in which the relationships between soil properties and P&amp;CA were strongest due to an ideal interplay among soil properties and terrain attributes. On 27 plots in a subtropical Chinese forest varying in tree and herb layer species richness and tree productivity, 29 soil properties in six depth columns and four terrain attributes were analyzed. Soil properties varied with soil depth as did their interrelationships. Non-linearity of soil properties led to critical soil depths in which different P&amp;CA characteristics were explained best (using coefficients of determination). The strongest relationship of soil properties and terrain attributes to most of P&amp;CA characteristics (adj. R 2 ~ 0.7) was encountered using a soil column of 0–16 cm. Thus, depending on the biological signal one is interested in, soil depth sampling has to be adapted. Considering P&amp;CA in subtropical broad-leaved secondary forests, we recommend sampling one bulk sample of a column from 0 cm down to a critical soil depth of 16 cm.
Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells
2019-06-14

It is well established that smoking has detrimental effects on bone integrity and is a preventable risk factor for metabolic bone disorders. Following orthopedic surgeries, smokers frequently show delayed fracture healing associated with many complications, which results in prolonged hospital stays. One crucial factor responsible for fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) at early stages, a mechanism mediated by transforming growth factor β (TGF-β). Although it is known that smokers frequently have decreased TGF-β levels, little is known about the actual signaling occurring in these patients. We investigated the effect of cigarette smoke on TGF-β signaling in MSCs to evaluate which step in the pathway is affected by cigarette smoke extract (CSE). Single-cell-derived human mesenchymal stem cell line (SCP-1 cells) were treated with CSE concentrations associated with smoking up to 20 cigarettes a day. TGF-β signaling was analyzed using an adenovirus-based reporter assay system. Primary cilia structure and downstream TGF-β signaling modulators (Smad2, Smad3, and Smad4) were analyzed by Western blot and immunofluorescence staining. CSE exposure significantly reduced TGF-β signaling. Intriguingly, we observed that protein levels of phospho-Smad2/3 (active forms) as well as nuclear translocation of the phospho-Smad3/4 complex decreased after CSE exposure, phenomena that affected signal propagation. CSE exposure reduced the activation of TGF-β modulators under constitutive activation of TGF-β receptor type I (ALK5), evidencing that CSE affects signaling downstream of the ALK5 receptor but not the binding of the cytokine to the receptor itself. CSE-mediated TGF-β signaling impaired MSC migration, proliferation, and differentiation and ultimately affected endochondral ossification. Thus, we conclude that CSE-mediated disruption of TGF-β signaling in MSCs is partially responsible for delayed fracture healing in smokers.
Nucleophilic Isomerization of Epoxides by Pincer‐Rhodium Catalysts: Activity Increase and Mechanistic Insights
2019-06-14

Abstract Herein, we present the efficient isomerization of epoxides into methyl ketones with a novel pincer‐rhodium complex under very mild conditions. The catalyst system has an excellent functional group tolerance and a wide array of epoxides was tested. The corresponding methyl ketones were obtained in very high yields with excellent chemo‐ and regioselectivity. In addition, we investigated mechanistic details like the isomerization of the catalyst, and we obtained evidence that the catalytic cycle follows a β‐hydride elimination‐reductive elimination pathway after the nucleophilic ring opening of the epoxide.
Pelagic Amphipods in the Eastern Fram Strait With Continuing Presence of Themisto compressa Based on Sediment Trap Time Series
2019-06-14

Pelagic amphipods represent a large fraction of organisms entering sediment traps as so-called “swimmers.” These swimmers were sampled with sediment traps (∼200– 300 m water depth) with two mooring arrays deployed at two different positions in the Long-Term Ecological Research observatory HAUSGARTEN in the northeastern Fram Strait. This sampling allowed us to investigate amphipod year-round abundances and inter-annual trends from 2000 onward. In this study, newly analyzed data from a 3-years period (August 2011–June 2014) are presented, extending this long-term investigation. In our results, the species Themisto abyssorum, T. libellula, and T. compressa dominated the swimmer biomass, corroborating previous studies. The observed increase of amphipod abundances persisted in all three species, additionally implying that Themisto compressa maintained its population off Svalbard, which appeared for the first time here after a warm anomaly in 2004–2007. This study provides evidence for changes in amphipod community patterns that can mainly be attributed to growing abundances of T. compressa. Similarly, another hyperiid, Lanceola clausii, also increased in abundance over the investigated period. For T. libellula, almost no juvenile individuals were recorded in the sampling period 2013/14, even though juveniles of this species were common in earlier records. The three more years of observations clearly suggest that recently documented environmental shifts persist in the eastern Fram Strait. They also highlight the merit of using sediment trap time series to obtain year-round data sets needed to &#13;\\nreveal processes and range shift dynamics in the pelagic system on a long-term basis.
Repetition Suppression for Noisy and Intact Faces in the Occipito-Temporal Cortex
2019-06-14

Repetition suppression (RS), the relative lower neural response magnitude to repeated as compared to non-repeated stimuli, is often explained within the predictive coding framework. According to this theory, precise predictions (priors) together with less precise sensory evidences lead to decisions that are determined largely by the predictions and the other way around. In other words, the prediction error, namely the magnitude of RS, should depend on the precision of predictions and sensory inputs. In the current study, we aimed at testing this idea by manipulating the clarity and thereby the precision of the incoming sensory data by adding noise to the images. This resulted in an fMRI adaptation design with repeated or alternating trials showing clear or noisy face stimuli. Our results show a noise effect on the activity in the fusiform face area (FFA), namely less activation for noisy than for clear trials, which supports previous findings. No such effects could be found in OFA or LO. Data also showed reliable RS in the FFA (bilateral) and unilaterally in OFA (right) and LO (left). Interestingly, the noise added to the stimuli did not affect the magnitude of RS in any of the tested cortical areas. This suggests that the clarity of the sensory input is not crucial in determining the magnitude of RS.
The Path to Type-II Superconductivity
2019-06-14

Following the discovery of superconductivity by Heike Kamerlingh Onnes in 1911, research concentrated on the electric conductivity of the materials investigated. Then, it was Max von Laue who in the early 1930s turned his attention to the magnetic properties of superconductors, such as their demagnetizing effects in a weak magnetic field. As a consultant at the Physikalisch-Technische Reichsanstalt in Berlin, von Laue was in close contact with Walther Meissner at the Reichsanstalt. In 1933, Meisner together with Robert Ochsenfeld discovered the perfect diamagnetism of superconductors (Meissner–Ochsenfeld effect). This was a turning point, indicating that superconductivity represents a thermodynamic equilibrium state and leading to the London theory and the Ginzburg–Landau theory. In the early 1950s in Moscow, Nikolay Zavaritzkii carried out experiments on superconducting thin films. In the theoretical analysis of his experiments, he collaborated with Alexei A. Abrikosov and for the first time they considered the possibility that the coherence length ξ can be smaller than the magnetic penetration depth λ m . They called these materials the “second group”. Subsequently, Abrikosov discovered the famous Abrikosov vortex lattice and the superconducting mixed state. The important new field of type-II superconductivity was born.
A School-Based Screening Tool for Adolescents With Low Motor Coordination Abilities
2019-06-14

This study sought to select the most relevant test items from the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOTMP-2) and from a selection of health-related fitness tests for identifying school teenagers with poor motor coordination. The 241 participants in this study (144 boys, 97 girls aged 13–14 years old) were tested on the short form of the BOTMP-2 and on the following additional fitness tests: (a) seated medicine ball test, (b) broad jump, (c) handgrip strength, (d) alternate hand ball wall toss, (e) 10 × 5-meter agility shuttle run, and (f) Chester step test. We performed a factor analysis of participant scores on these various tasks and BOTMP-2 test items to reduce them to the least number of meaningful and useful items. Four factors explained 45% of the data variance: gross motor skills and power (including broad jump, hand ball toss, shuttle run, and sit-ups tests); fine motor skills (including copying star, following the maze and paper folding); core strength and balance (including push-ups, hopping, and balance beam); and general body strength (including medicine ball throw and handgrip). We conclude that an efficient school-based battery of test items to screen 13-14 year old adolescents for fitness and coordination should assess these four factors and might especially rely upon the broad jump, copying a star shape, hopping handgrip strength, aerobic fitness, and wall ball toss.
Miocene basement exhumation in the Central Alps recordedby detrital garnet geochemistry in foreland basin deposits
2019-06-14

Abstract. The Neogene evolution of the European Alps was characterized by the exhumation of crystalline basement, the so-called external crystalline massifs. Their exhumation presumably controlled the evolution of relief, distribution of drainage networks and generation of sediment in the Central Alps. However, due to the absence of suitable proxies, the timing of their surficial exposure, and thus the initiation of sediment supply from these areas, are poorly constrained. The northern alpine foreland basin preserves the Oligocene to Miocene sedimentary record of tectonic and climatic adjustments in the hinterland. This contribution analyses the provenance of 25 to 14 My-old alluvial fan deposits by means of detrital garnet chemistry. Unusually grossular- and spessartine-rich garnets are found to be unique proxies for identifying detritus from the external crystalline massifs. In the foreland basin, these garnets are abundant in 14 My-old deposits, thus providing a minimum age for the surficial exposure of the crystalline basement.
Sharp one-sided curvature estimates for fully nonlinear curvature flows and applications to ancient solutions
2019-06-14

Abstract We prove several sharp one-sided pinching estimates for immersed and embedded hypersurfaces evolving by various fully nonlinear, one-homogeneous curvature flows by the method of Stampacchia iteration. These include sharp estimates for the largest principal curvature and the inscribed curvature (“cylindrical estimates”) for flows by concave speeds and a sharp estimate for the exscribed curvature for flows by convex speeds. Making use of a recent idea of Huisken and Sinestrari, we then obtain corresponding estimates for ancient solutions. In particular, this leads to various characterisations of the shrinking sphere amongst ancient solutions of these flows.
Unravelling the thermal evolution of the Neruokpuk Formation in the British Mountains, North Yukon, Canada: Tectonic and orogenic implications
2019-06-14

ABSTRACT Defining temporal and spatial distribution of shortening is critical to reconstruct past plate motions and to examine mechanical coupling processes at convergent plate boundaries. Understanding the collisional evolution of the British Mountains and Beaufort-MacKenzie basin in the northern Alaska–Yukon region is key for the geodynamics of the Arctic region. With the aim to resolve the exhumation history of this region, we present the first zircon fission-track and (U-Th)/He analyses on apatite and zircon from the Neruokpuk Formation (ca. 720–485 Ma), which forms the orogenic basement of the British Mountains. Zircon fission-track ages show partial resetting, indicating the Proterozoic basement did not reside at temperatures above 240 °C. Thermal modeling of zircon and apatite (U-Th)/He data indicates that our samples reached this maximum temperature at ca. 100 Ma. The onset of the Brookian collision is indicated by exhumation from ca. 80 Ma. A total exhumation of 7–8.5 km since the Late Cretaceous is inferred. Apatite (U-Th)/He ages of ca. 50 Ma show that exhumation was less than 2.5 km since the early Eocene. We infer from a comparison with the temporal evolution of exhumation from adjacent orogenic domains that shortening progressively shifted northward from the British Mountains to the Barn Mountains and offshore in the Beaufort Sea during the Paleocene. Along-strike variations in the architecture of the rifted margin of Arctic Alaska is suggested to have exerted a strong control on the structural styles and observed exhumation patterns.
Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease
2019-06-15

Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models of Huntington disease (HD). However, the invasive nature of surgical procedure and its potential to trigger the host immune response may limit its clinical use. Hence, we sought to evaluate the non-invasive intranasal administration (INA) of MSC delivery as an effective alternative route in HD. GFP-expressing MSCs derived from bone marrow were intranasally administered to 4-week-old R6/2 HD transgenic mice. MSCs were detected in the olfactory bulb, midbrain and striatum five days post-delivery. Compared to phosphate-buffered saline (PBS)-treated littermates, MSC-treated R6/2 mice showed an increased survival rate and attenuated circadian activity disruption assessed by locomotor activity. MSCs increased the protein expression of DARPP-32 and tyrosine hydroxylase (TH) and downregulated gene expression of inflammatory modulators in the brain 7.5 weeks after INA. While vehicle treated R6/2 mice displayed decreased Iba1 expression and altered microglial morphology in comparison to the wild type littermates, MSCs restored both, Iba1 level and the thickness of microglial processes in the striatum of R6/2 mice. Our results demonstrate significantly ameliorated phenotypes of R6/2 mice after MSCs administration via INA, suggesting this method as an effective delivering route of cells to the brain for HD therapy.
Neurovascular anatomy of the protostegid turtle Rhinochelys pulchriceps and comparisons of membranous and endosseous labyrinth shape in an extant turtle
2019-06-15

Abstract Chelonioid turtles are the only surviving group of reptiles that secondarily evolved marine lifestyles during the Mesozoic Early chelonioid evolution is documented by fossils of their stem group, such as protostegids, which yield insights into the evolution of marine adaptation. Neuroanatomical features are commonly used to infer palaeoecology owing to the functional adaptation of the senses of an organism to its environment. We investigated the neuroanatomy and carotid circulation of the early Late Cretaceous protostegid Rhinochelys pulchriceps based on micro-computed tomography data. We show that the trigeminal foramen of turtles is not homologous to that of other reptiles. The endosseous labyrinth of R. pulchriceps has thick semicircular canals and a high aspect ratio. Comparisons among turtles and other reptiles show that the endosseous labyrinth aspect ratio is not a reliable predictor of the degree of aquatic adaptation, contradicting previous hypotheses. We provide the first models of neuroanatomical soft tissues of an extant turtle. Turtle brain morphology is not reflected by the brain cavity, and the endosseous labyrinth provides an incomplete reflection of membranous semicircular duct morphology. Membranous labyrinth geometry is conserved across gnathostomes, which allows approximate reconstruction of the total membranous labyrinth morphology from the endosseous labyrinth despite their poor reflection of duct morphology.
Women directors, firm performance, and firm risk: A causal perspective
2019-06-16

Norway was the first of ten countries to legislate gender quotas for boards of publicly traded firms. There is considerable debate and mixed evidence concerning the implications of female board representation. In this paper, we explain the main sources of biases in the existing literature on the effects of women directors on firm performance and review methods to account for these biases. We address the endogeneity problem by using a difference-in-differences approach to study the effects of women directors on firm performance with specific consideration of the common trend assumption, and we explicitly distinguish between accounting-based (i.e., operating income divided by assets, return on assets) and market-based (i.e., market-to-book ratio and Tobin's Q) performance measures in the Norwegian setting. The control group are firms from Finland, Sweden, and Denmark. We further extend the analysis of causal effects of women directors to firm risk. Our results imply a negative effect of mandated female representation on firm performance and on firm risk.
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
2019-06-16

About 1% of all newborns are affected by congenital heart disease (CHD). Recent findings identify aberrantly functioning cilia as a possible source for CHD. Faulty cilia also prevent the development of proper left-right asymmetry and cause heterotaxy, the incorrect placement of visceral organs. Intriguingly, signaling cascades such as mTor that influence mitochondrial biogenesis also affect ciliogenesis, and can cause heterotaxy-like phenotypes in zebrafish. Here, we identify levels of mitochondrial function as a determinant for ciliogenesis and a cause for heterotaxy. We detected reduced mitochondrial DNA content in biopsies of heterotaxy patients. Manipulation of mitochondrial function revealed a reciprocal influence on ciliogenesis and affected cilia-dependent processes in zebrafish, human fibroblasts and Tetrahymena thermophila. Exome analysis of heterotaxy patients revealed an increased burden of rare damaging variants in mitochondria-associated genes as compared to 1000 Genome controls. Knockdown of such candidate genes caused cilia elongation and ciliopathy-like phenotypes in zebrafish, which could not be rescued by RNA encoding damaging rare variants identified in heterotaxy patients. Our findings suggest that ciliogenesis is coupled to the abundance and function of mitochondria. Our data further reveal disturbed mitochondrial function as an underlying cause for heterotaxy-linked CHD and provide a mechanism for unexplained phenotypes of mitochondrial disease.
The CARMENES search for exoplanets around M dwarfs
2019-06-17

Context. Teegarden’s Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0 V), the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES. Aims. As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden’s Star and analysed them for planetary signals. Methods. We find periodic variability in the radial velocities of Teegarden’s Star. We also studied photometric measurements to rule out stellar brightness variations mimicking planetary signals. Results. We find evidence for two planet candidates, each with 1.1 M ⊕ minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. No evidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotation and old age. Conclusions. The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cool dwarf for which the masses have been determined using radial velocities.
Contribution of Microaerophilic Iron(II)-Oxidizers to Iron(III) Mineral Formation
2019-06-17

Neutrophilic microbial aerobic oxidation of ferrous iron (Fe(II)) is restricted to pH-circumneutral environments characterized by low oxygen where microaerophilic Fe(II)-oxidizing microorganisms successfully compete with abiotic Fe(II) oxidation. However, accumulation of ferric (bio)minerals increases competition by stimulating abiotic surface-catalyzed heterogeneous Fe(II) oxidation. Here, we present an experimental approach that allows quantification of microbial and abiotic contribution to Fe(II) oxidation in the presence or initial absence of ferric (bio)minerals. We found that at 20 μM O<sub>2</sub> and the initial absence of Fe(III) minerals, an iron(II)-oxidizing enrichment culture (99.6% similarity to <i>Sideroxydans</i> spp.) contributed 40% to the overall Fe(II) oxidation within approximately 26 h and oxidized up to 3.6 × 10<sup>-15</sup> mol Fe(II) cell<sup>-1</sup> h<sup>-1</sup>. Optimum O<sub>2</sub> concentrations at which enzymatic Fe(II) oxidation can compete with abiotic Fe(II) oxidation ranged from 5 to 20 μM. Lower O<sub>2</sub> levels limited biotic Fe(II) oxidation, while at higher O<sub>2</sub> levels abiotic Fe(II) oxidation dominated. The presence of ferric (bio)minerals induced surface-catalytic heterogeneous abiotic Fe(II) oxidation and reduced the microbial contribution to Fe(II) oxidation from 40% to 10% at 10 μM O<sub>2</sub>. The obtained results will help to better assess the impact of microaerophilic Fe(II) oxidation on the biogeochemical iron cycle in a variety of environmental natural and anthropogenic settings.