julilili42/papers huggingface dataset:
Conscientiousness and externalizing psychopathology: Overlap, developmental patterns, and etiology of two related constructs–Corrigendum
2010-06-24

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ChemInform Abstract: Synthesis and Properties of Tetracyanamidosilicates ARE[Si(CN2)4].
2010-06-24

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
2010-06-25

Let There Be Light Retinitis pigmentosa, a disease that can result from a wide variety of genetic defects, causes degeneration of photoreceptor cells in the retina and leads to blindness. In the course of the disease, it is generally the rod photoreceptor cells that degenerate first. Cone photoreceptor cells may persist, but in a damaged and nonfunctional state. Busskamp et al. (p. 413 , published online 24 June; see the cover; see the Perspective by Cepko ) have now applied a gene therapy approach to mouse models of retinitis pigmentosa. Inducing expression of a bacterial light-activated ion pump, halorho dopsin, in the damaged cone cells improved visual responses in the diseased mouse retinas. Thus, it may be possible to rescue cone photoreceptors therapeutically, even after they have already been damaged.
Radiative decays of double heavy baryons in a relativistic constituent three-quark model including hyperfine mixing effects
2010-06-25

We study flavor-conserving radiative decays of double heavy baryons using a\\nmanifestly Lorentz covariant constituent three-quark model. Decay rates are\\ncalculated and compared to each other in the full theory, keeping masses\\nfinite, and also in the heavy quark limit. We discuss in some detail hyperfine\\nmixing effects.\\n
Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry
2010-06-25

For small datasets (a few hundred proteins) it is possible to solve the problem to optimality with moderate computational effort using commercial or free solvers. Larger datasets, like full proteomes require the use of heuristics.
Inside Cover: Synthesis and Biological Testing of N‐Aminoimidazole‐Based p38α MAP Kinase Inhibitors (ChemMedChem 7/2010)
2010-06-25

The inside cover picture shows an N-aminoimidazole-based p38α MAP kinase inhibitor (11 f in the manuscript) docked in the target binding site (PDB ID: 3HL7). A novel synthetic route to tetrasubstituted N-aminoimidazoles was established. Acyl substitution of these N-aminoimidazoles yielded low nanomolar inhibitors (e.g., 11 f, IC50 = 58 nM). For more details, see the Full Paper by S. A. Laufer et al. on p. 1134 ff.
Supporting participation in organizational information exchange: psychological recommendations
2010-06-26

Purpose The aim of this article is to show how members of an organization can be encouraged to participate actively in information exchange and in the creation of an organizational knowledge base. Design/methodology/approach This article addresses this issue by providing recommendations from motivational and social psychology. Findings The article provides recommendations concerning people's need for self‐determination, for social relations, regarding their reputation, and their need for favorable self‐presentation. Originality/value The recommendations from motivational and social psychology are supposed help organizations to support participation in organizational information exchange.
Coping with amyotrophic lateral sclerosis: an integrative view
2010-06-28

The focus on medical issues in treatment of ALS is not sufficient. A palliative approach to ALS must equally imply advice with regards to adequate coping strategies, provide the adequate amount of disease- and support-related information at any one time, and encourage patients to seek social support. Sufficient medication and psychotherapy has to be provided for those patients who show depressive symptoms or disorder.
Cold atoms near superconductors: atomic spin coherence beyond the Johnson noise limit
2010-06-28

We report on the measurement of atomic spin coherence near the surface of a\\nsuperconducting niobium wire. As compared to normal conducting metal surfaces,\\nthe atomic spin coherence is maintained for time periods beyond the Johnson\\nnoise limit. The result provides experimental evidence that magnetic near field\\nnoise near the superconductor is strongly suppressed. Such long atomic spin\\ncoherence times near superconductors open the way towards the development of\\ncoherently coupled cold atom / solid state hybrid quantum systems with\\npotential applications in quantum information processing and precision force\\nsensing.\\n
Discovery of VHEγ-rays from the BL Lacertae object PKS 0548–322
2010-06-28

Aims. PKS 0548-322 (z=0.069) is a "high-frequency-peaked'' BL Lac object and a candidate very high energy (VHE, E &gt;100 GeV) -ray emitter, due to its high X-ray and radio flux. Observations at the VHE band provide insights into the origin of very energetic particles present in this source and the radiation processes at work.&#13;\\nMethods. We report observations made between October 2004 and January 2008 with the HESS array, a four imaging atmospheric-Cherenkov telescopes. Contemporaneous UV and X-ray observations with the Swift satellite in November 2006 are also reported.&#13;\\nResults. PKS 0548-322 is detected for the first time in the VHE band with HESS We measure an excess of 216 -rays corresponding to a significance of 5.6 standard deviations. The photon spectrum of the source is described by a power-law, with a photon index of . The integral flux above 200 GeV is 1.3% of the flux of the Crab Nebula, and is consistent with being constant in time. Contemporaneous Swift/XRT observations reveal an X-ray flux between 2 and 10 keV of , an intermediate intensity state with respect to previous observations. The spectral energy distribution can be reproduced using a simple one-zone synchrotron self Compton model, with parameters similar those observed for other sources of this type
Closed formulas for ground band energies of nuclei with various symmetries
2010-06-28

A time-dependent variational principle is used to dequantize a second-order quadrupole boson Hamiltonian. The classical equations for the generalized coordinate and the constraint for the angular momentum are quantized and then analytically solved. A generalized Holmberg–Lipas formula for energies is obtained. A similar J(J + 1) dependence is provided by the coherent state model in the large deformation regime, by using an expansion in powers of 1/x for energies, with x denoting a deformation parameter squared. A simple compact expression is also possible for the near-vibrational regime. These three expressions have been used for 44 nuclei covering regions characterized by different dynamic symmetries or in other words belonging to all the known nuclear phases. Nuclei satisfying the specific symmetries of the critical point in the phase transitions O(6) → SU(3), SU(5) → SU(3) have also been considered. The agreement between the results and the corresponding experimental data is very good. This is reflected in very small root mean square values of deviations.
Single-atom detection on a chip: from realization to application
2010-06-28

In this paper, we describe the preparation and detection of ultracold atoms on a microchip with single-atom sensitivity. The detection scheme is based on multi-photon ionization of atoms and the subsequent guiding of the generated ions by ion optics to a channel electron multiplier. We resolve single atoms with a detection efficiency above 60%. The detector is suitable for real-time observations of static and dynamic processes in ultracold quantum gases. Although the ionization is destructive, sampling a small subset of the atomic distribution is sufficient for the determination of the desired information. We take full high-resolution spectra of ultracold atoms by ionizing only 5% of the atoms. Using an additional microwave near 6.8 GHz, the detection scheme becomes energy, position and state selective. This can be used for in situ determination of the energy distribution and temperature of atom clouds inside the trap and applied for future correlation measurements.
A Free–Wilson‐like Approach to Analyze QSAR Models Based on Graph Decomposition Kernels
2010-06-28

Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development
2010-06-29

We show that DCC and netrin-1 are ubiquitously expressed in the human foetal brain; however, both exhibit a distinct spatio-temporal expression pattern. Together with the data from animal experiments, our findings might indicate also an important role for DCC and netrin-1 in human foetal CNS development.
Synthesis of the Guaianolide Ring System via Cycloaddition of a Bicyclic Carbonyl Ylide with Allyl Propiolate
2010-06-29

A cyclic carbonyl ylide with a trans-annulated cyclopentane ring was generated by a Rh(2)(OAc)(4)-catalyzed reaction from a diazoketone precursor and trapped with allyl propiolate. The 1,3-dipolar cycloaddition led to the stereoselective formation of an oxygen-bridged polycycle. Via Curtius degradation, the cycloadduct was transformed to the ring skeleton typical of the sesquiterpene family of guaianolides.
The use of a digital dance mat for training kindergarten children in a magnitude comparison task
2010-06-29

Previous studies demonstrated that basic numerical skills reliably predict children's future mathematical performance. The spatial representation of numerical magnitude, represented in the form of a mental number line, seems to be of particular importance. Our training program for kindergarten children used a digital dance mat as input device that required children to move their whole body to respond in a magnitude comparison task. By employing such a spatial embodied training method, in a parallel randomized cross-over design, our study with 19 kindergarten children revealed a significant interaction between training condition and repeated exposure to items, implying that children improved more strongly in the dance mat than in the control condition. These results suggest that the use of digital media to train embodied spatial numerical skills may be more effective in basic numerical tasks such as magnitude comparison. We suggest that the involvement of embodied spatial codes, shared by the representation addressed by the task at hand, aids acquisition of task-relevant basic numerical skills.
Social software and knowledge building: supporting co-evolution of individual and collective knowledge
2010-06-29

This paper presents a framework model that defines learning and knowledge building as a co-evolution of cognitive and social systems. This model brings together Scardamalia and Bereiter's theory of knowledge building and Nonaka's knowledge creation theory. We demonstrate how learning and knowledge building may occur when people interact with each other, using shared digital artifacts such as tag clouds (that result from social-tagging activities) or wikis. For both technologies, we provide illustrating data from two pilot studies. As an example, we refer to the learning processes that take place while searching for information in tag clouds. In addition, we illustrate processes of knowledge building by referring to users working on a wiki. In conclusion, the differences and similarities between these technologies are assessed, regarding their potential for knowledge building.
Fully coupled hydrogeophysical inversion of synthetic salt tracer experiments
2010-06-30

We present a method for the determination of hydraulic conductivity from monitoring of salt tracer tests by electrical resistivity tomography (ERT). To ensure that the underlying principles of flow, transport, and geoelectrics are obeyed in the inversion, we perform a fully coupled hydrogeophysical analysis using temporal moments of electrical potential perturbations. In the predictive mode, we use moment‐generating equations with corresponding adjoint equations for the evaluation of sensitivities. For inversion, we apply the quasi‐linear geostatistical inversion approach. The method is tested in a synthetic case study mimicking a laboratory‐scale quasi two‐dimensional sandbox, in which 48 electrodes and 8 piezometers are used. The hydraulic conductivity field is estimated from the mean arrival times of electrical potential perturbations and hydraulic heads. The estimated hydraulic conductivity field reproduces most features with, however, a loss of variability. Even though only the temporal moments of the electrical signals are used for inversion, the transient behavior is satisfactorily recovered. Also, the spatial patterns of concentration arrival times in the true and estimated cases are in good agreement, so that the propagation of the tracer plume can be followed fairly accurately. We test the effects of large measurement errors and erroneous prior information on the performance of the inversion. While prior statistical parameters are of minor importance in detecting the major pattern of hydraulic conductivity, a large measurement error could have an important impact on the solution. Also, the choice of electrode configurations appears to be important. In particular, strictly surface‐based geoelectrical surveys do not seem to be very suitable for identifying spatial patterns of hydraulic conductivity by ERT monitoring of salt tracer tests within aquifers.
New approach toward a direct evaluation of the multichannel multienergySmatrix without solving the scattering equations
2010-06-30

A novel method which allows us to find observables at many energies simultaneously in a multichannel scattering problem using just a single diagonalization of the total Hamiltonian matrix in some basis is developed. The approach is based on the multichannel generalization of ideas due to Lifshits and Birman-Krein on the tight relationship between a spectral shift function and a single-channel matrix in the combination with discretization of the continuum. As a clear illustration for the efficiency of the suggested method, the differential cross sections of neutron scattering off heavy nuclei in the case of a complex nonlocal interaction potential as well as energy dependence of partial phase shifts and mixing parameters for the two-nucleon scattering with tensor force are calculated.
PITPNM3 is an uncommon cause of cone and cone-rod dystrophies
2010-06-30

The first mutation in PITPNM3, a human homologue of the Drosophila retinal degeneration (rdgB not not) gene was reported in two large Swedish families with autosomal dominant cone dystrophy. To establish the global impact that PITPNM3 has on retinal degenerations we screened 163 patients from Denmark, Germany, the UK, and USA. Four sequence variants, two missence mutations and two intronic changes were identified in the screen. Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.
Application of a novel and low cost technique to construct paraffin tissue microarrays out of paraffinised needle biopsy specimens from patients with breast cancer
2010-06-30

Background Paraffin tissue microarrays (TMAs) are a well accepted tool in pathology for high throughput molecular profiling, quality control and clinicopathological trials. No reports on TMAs constructed from paraffinised needle biopsy specimens (PNBSs) derived from patients with breast cancer can be found in the literature. PNBSs are sometimes the only source for tumour characterisation important for treatment. Aim To develop a novel and low cost technique to construct TMAs from PNBSs (PNBSs–TMAs) in order to close this gap in TMA technology. Methods Using a skin biopsy punch, tumour-bearing parts of 84 PNBSs were punched out of the donor blocks, freed from the surrounding paraffin by melting and manually transferred into the preformed holes in the recipient block. After filling the holes, the PNBSs–TMA was fixed to a double sided adhesive tape and completely melted. Quality assessment of this new technique was performed comparing the HER2 status (synonym: cerbB2) of the PNBSs–TMA with the results of the original PNBSs and a TMA harbouring the tumour in corresponding resection and mastectomy specimens (RM–TMA). Results A 187-hole PNBSs–TMA with 84 PNBSs was successfully constructed. About 1% of the included PNBSs displayed signs of rolling and folding or of floating off the slide during the staining procedure. The results of immunohistochemistry, fluorescence in situ hybridisation and automated brightfield double in situ hybridisation showed high quality standard of the PNBSs–TMA, suitable for precise tumour profiling. Conclusions PNBSs–TMAs are suitable for clinicopathological trials, especially those in which PNBSs are the only tumour source.
Partielle Diﬀerentialgleichungen
2010-06-30

The workshop dealt with partial differential equations in geometry and technical applications. The main topics were the combination of nonlinear partial differential equations and geometric problems, regularity of free boundaries, conformal invariance and the Willmore functional.
Stata Tip 87: Interpretation of Interactions in Nonlinear Models
2010-07-01

When estimating a non-linear model such as [R] logit or [R] poisson, we often have two options when it comes to interpreting the regression coefficients: compute some form of marginal effect; or exponentiate the coefficients, which will give us an odds ratio or incidence-rate ratio. The marginal effect is an approximation of how much the dependent variable is expected to increase or decrease for a unit change in an explanatory variable: that is, the effect is presented on an additive scale. The exponentiated coefficients give the ratio by which the dependent variable changes for a unit change in an explanatory variable: that is, the effect is presented on a multiplicative scale. An extensive overview is given by Long and Freese (2006). Sometimes we are also interested in how the effect of one variable changes when another variable changes, namely, the interaction effect. As there is more than one way in which we can define an effect in a non-linear model, there must also be more than one way in which we can define an interaction effect. This tip deals with how to interpret these interaction effects when we want to present effects as odds ratios or incidence-rate ratios. This can be an attractive alternative to interpreting interactions effects in terms of marginal effects.
Isolation and Characterization of Bacteria from the Gut ofBombyx morithat Degrade Cellulose, Xylan, Pectin and Starch and Their Impact on Digestion
2010-07-01

Bombyx mori L. (Lepidoptera: Bombycidae) have been domesticated and widely used for silk production. It feeds on mulberry leaves. Mulberry leaves are mainly composed of pectin, xylan, cellulose and starch. Some of the digestive enzymes that degrade these carbohydrates might be produced by gut bacteria. Eleven isolates were obtained from the digestive tract of B. mori, including the Gram positive Bacillus circulans and Gram negative Proteus vulgaris, Klebsiella pneumoniae, Escherichia coli, Citrobacter freundii, Serratia liquefaciens, Enterobacter sp., Pseudomonas fluorescens, P. aeruginosa, Aeromonas sp., and Erwinia sp.. Three of these isolates, P. vulgaris, K. pneumoniae, C. freundii, were cellulolytic and xylanolytic, P. fluorescens and Erwinia sp., were pectinolytic and K. pneumoniae degraded starch. Aeromonas sp. was able to utilize the CMcellulose and xylan. S. liquefaciens was able to utilize three polysaccharides including CMcellulose, xylan and pectin. B. circulans was able to utilize all four polysaccharides with different efficacy. The gut of B. mori has an alkaline pH and all of the isolated bacterial strains were found to grow and degrade polysaccharides at alkaline pH. The number of cellulolytic bacteria increases with each instar.
Fast and Scalable CPU/GPU Collision Detection for Rigid and Deformable Surfaces
2010-07-01

Abstract We present a new hybrid CPU/GPU collision detection technique for rigid and deformable objects based on spatial subdivision. Our approach efficiently exploits the massive computational capabilities of modern CPUs and GPUs commonly found in off‐the‐shelf computer systems. The algorithm is specifically tailored to be highly scalable on both the CPU and the GPU sides. We can compute discrete and continuous external and self‐collisions of non‐penetrating rigid and deformable objects consisting of many tens of thousands of triangles in a few milliseconds on a modern PC. Our approach is orders of magnitude faster than earlier CPU‐based approaches and up to twice as fast as the most recent GPU‐based techniques.
Percutaneous pulmonary valve replacement: autologous tissue-engineered valved stents
2010-07-01

Good functioning and morphological characteristics were observed after percutaneous tissue-engineered valved stent implantation with autologous cells. This implantation of autologous tissue-engineered valved stents will become a valid future option in adolescents.
A Prospective Randomized Study of Minimally Invasive Total Knee Arthroplasty Compared with Conventional Surgery
2010-07-01

On the basis of the numbers, no significant advantage to minimally invasive total knee arthroplasty over a conventional technique was observed. Greater sample sizes and a longer follow-up period are required to fully determine the long-term safety and efficacy of this minimally invasive surgical technique.
Does the Cognitive Dispute of Psychotic Symptoms do Harm to the Therapeutic Alliance?
2010-07-01

We examined whether the cognitive dispute of psychotic symptoms has a negative impact on the course of the therapeutic alliance. Sixty-seven patients with persistent psychotic symptoms received either cognitive behavioral therapy (CBT) or supportive therapy. Questionnaire-based alliance ratings were repeatedly obtained throughout the course of therapy. Patient and therapist alliance ratings were examined separately. Data analyses comprised repeated measurement analyses of variance and cluster analytic procedures. Neither patient nor therapist alliance ratings showed a differential course throughout the treatments. This was despite the implementation of disputing strategies in later stages of CBT. Irrespective of the treatment condition a cluster with a positive alliance rating and a cluster with a poorer rating were found for therapist and patient ratings, respectively. Baseline symptoms and insight differentiated between the types of clusters. In conclusion, CBT-specific interventions that challenge psychotic symptoms do not necessarily negatively influence the course of the alliance.