julilili42/papers huggingface dataset:
Religious Transformations in the Middle Ages: Towards a New Archaeological Agenda
2017-07-03

L'articolo esplora dal punto di vista archeologico le varie tracce materiali lasciate dalle forme cultuali proprie del Medioevo, colte nei loro aspetti di trasformazioni religiose. L'analisi riguarda contesti pagani, cristiani, islamici ed ebrei, visti attraverso una prospettiva di lungo termine. I concetti base sono quelli di ibridità, resilienza, tempi e traiettorie. Un'attenzione particolare è data al modo in cui credenze, pratiche e identità religiose vennero rinegoziate dai popoli del Medioevo nel corso della vita quotidiana.
Peripheral Design of Progressive Addition Lenses and the Lag of Accommodation in Myopes
2017-07-03

Insufficient accommodative response is assumed to result in myopia progression. We have investigated if the accommodative lag in myopes is different between a single vision lens (SVL) and the progressive addition lens PAL 2, clinically trialled for its ability to reduce progression of myopia, and if there exist differences in accommodative lag between PAL 2 and other PALs with the same addition power (+1.50 D).The influence of spherical SVL and four different designs of PALs that differ in the near zone width (PAL 1) or that have different signs and magnitude of horizontal gradients of mean power adjacent to their near vision zones (PAL 3 and PAL 4) on the accommodative response was investigated for different near viewing distances (40, 33, and 25 cm) in 31 subjects, aged 18 to 25 years.The SVL correction resulted in insufficient accommodative response for the near object viewing distances tested. PAL 2 did significantly reduce accommodative lag for all near object distances tested. The PAL design with a more negative horizontal mean power gradient (PAL 4) provided a lower lag of accommodation when compared with PAL 2 at the shortest object distance of 25 cm (P = 0.03) and was able to reduce the lag of accommodation to a level below the depth of focus for the higher near working distances tested.Designs of PAL with more negative horizontal mean power gradients are the most effective in lowering the lag of accommodation in myopes. This could make them good test candidates for myopia control applications.
Migrant background, culture and ethnicity: sociological terms without explanatory value?!
2017-07-03

In the case of the person who is a stranger to the country, the city, the race, etc., however, this non-common element is once more nothing individual, but merely the strangeness of origin, which i...
Fiber-Reinforced Plastics with Locally Adapted Stiffness for Bio-Inspired Hingeless, Deployable Architectural Systems
2017-07-03

This paper presents results of the investigation of two biological role models, the shield bug ( Graphosoma italicum ) and the carnivorous Waterwheel plant ( Aldrovanda vesiculosa ). The aim was to identify biological construction and movement principles as inspiration for technical, deployable systems. The subsequent processes of abstraction and simulation of the movement and the design principles are summarized, followed by results on the mechanical investigations on various combinations of fibers and matrices with regard to taking advantage of the anisotropy of fiber-reinforced plastics (FRPs). With the results gained, it was possible to implement defined flexible bending zones in stiff composite components using one composite material, and thereby to mimic the biological role models. First small-scale demonstrators for adaptive façade shading systems – Flectofold and Flexagon – are proving the functionality.
Significant differentiation in the apolipoprotein(a)/lipoprotein(a) trait between chimpanzees from Western and Central Africa
2017-07-03

Elevated Lipoprotein(a) (Lp(a)) plasma concentrations are a risk factor for cardiovascular disease in humans, largely controlled by the LPA gene encoding apolipoprotein(a) (apo(a)). Lp(a) is composed of low‐density lipoprotein (LDL) and apo(a) and restricted to Catarrhini . A variable number of kringle IV (KIV) domains in LPA lead to a size polymorphism of apo(a) that is inversely correlated with Lp(a) concentrations. Smaller apo(a) isoforms and higher Lp(a) levels in central chimpanzees ( Pan troglodytes troglodytes [PTT]) compared to humans from Europe had been reported. We studied apo(a) isoforms and Lp(a) concentrations in 75 western ( Pan troglodytes verus [PTV]) and 112 central chimpanzees, and 12 bonobos ( Pan paniscus [PPA]), all wild born and living in sanctuaries in Sierra Leone, Republic of the Congo, and DR Congo, respectively, and 116 humans from Gabon. Lp(a) levels were severalfold higher in western than in central chimpanzees (181.0 ± 6.7 mg/dl vs. 56.5 ± 4.3 mg/dl), whereas bonobos showed intermediate levels (134.8 ± 33.4 mg/dl). Apo(a) isoform sizes differed significantly between subspecies (means 20.9 ± 2.2, 22.9 ± 4.4, and 23.8 ± 3.8 KIV repeats in PTV, PTT, and PPA, respectively). However, far higher isoform‐associated Lp(a) concentrations for all isoform sizes in western chimpanzees offered the main explanation for the higher overall Lp(a) levels in this subspecies. Human Lp(a) concentrations (mean 47.9 ± 2.8 mg/dl) were similar to those in central chimpanzees despite larger isoforms (mean 27.1 ± 4.9 KIV). Lp(a) and LDL, apoB‐100, and total cholesterol levels only correlated in PTV. This remarkable differentiation between chimpanzees from different African habitats and the trait's similarity in humans and chimpanzees from Central Africa poses the question of a possible impact of an environmental factor that has shaped the genetic architecture of LPA . Overall, studies on the cholesterol‐containing particles of Lp(a) and LDL in chimpanzees should consider differentiation between subspecies.
Form and Instability: Eastern Europe, Literature, Postimperial Difference
2017-07-03

Anita Starosta’s analyses are original and refreshing; however, as a more general overview, her Form and Instability requires a few words of commentary.The book consists of two parts: the first is ...
Motor expertise facilitates the precision of state extrapolation in perception
2017-07-03

Abstract Predicting the behavior of objects in the environment is an important requirement to overcome latencies in the sensorimotor system and realize precise actions in rapid situations. Internal forward models that were acquired during motor training might not only be used for efficiently controlling fast motor behavior but also to facilitate extrapolation performance in purely perceptual tasks. In this study, we investigated whether preceding virtual cart-pole balancing training facilitates the ability to extrapolate the pole motion. We compared a group of 10 subjects, proficient in performing the cart-pole balancing task, to 10 naïve subjects. Our results demonstrate that preceding motor training increases the precision of pole movement extrapolation, although extrapolation is not trained explicitly. Additionally, we modelled subjects’ behaviors and show that the difference in extrapolation performance can be explained by individual differences in the accuracy of internal forward models. When subjects are provided with feedback about the true pole movement in a second phase, both groups improve rapidly. The results indicate that the perceptual capability to extrapolate the state of the cart-pole system accurately is implicitly trained during motor learning. We discuss these results in the context of shared representations and action-perception transfer.
Language in International Business: A Review and Agenda for Future Research
2017-07-04

A fast growing number of studies demonstrates that language diversity influences almost all management decisions in modern multinational corporations. Whereas no doubt remains about the practical importance of language, the empirical investigation and theoretical conceptualization of its complex and multifaceted effects still presents a substantial challenge. To summarize and evaluate the current state of the literature in a coherent picture informing future research, we systematically review 264 articles on language in international business.&#13;\\n&#13;\\nWe scrutinize the geographic distributions of data, evaluate the field’s achievements to date in terms of theories and methodologies, and summarize core findings by individual, group, firm, and country levels of analysis. For each of these dimensions, we then put forward a future research agenda. We encourage scholars to transcend disciplinary boundaries and to draw on, integrate, and test a variety of theories from disciplines such as psychology, linguistics, and neuroscience to gain a more profound understanding of language in international business. We advocate more multi-level studies and cross-national research collaborations and suggest greater attention to potential new data sources and means of analysis.
Evaluation of the accuracy of nine electronic apex locators by using Micro‐CT
2017-07-04

Abstract Aim To determine the accuracy of locating the apical constriction using apex locators. Methodology Extracted teeth were micro‐ CT scanned preoperatively to localize the apical constriction. Electronic length measurements of 91 root canals were made using nine electronic apex locators ( EAL ) connected to a mounting model. Distances from the major foramen were recorded at each scale bar of the EAL s, and a file was fixed in the canal at a position indicated by each EAL to be the apical constriction. A second micro‐ CT scan was conducted, and distances from the file tip to constriction and major foramen were calculated for each EAL . The accuracy of EAL s was determined with a tolerance of 0.1, 0.25, 0.5 and 1 mm, and the 95% confidence interval was used to compare the EAL s. A rank analysis was performed in which measurements beyond the major foramen were considered as inaccurate. Results Regardless of the type of teeth, there was no significant difference in the accuracy of determining the apical constriction and major foramen between the nine EAL s within a tolerance of ±0.5 mm and 1 mm, but there was a significant difference for the tolerances of ±0.1 and 0.25 mm. The highest ranks close to the constriction (98% and 94%) and to the major foramen (86% and 73%) were observed in Dentaport ZX and Elements Diagnostic Unit, respectively. Overestimation of working length beyond the major foramen was observed in all EAL s (5% to 71%) when the scale for the major foramen, as recommended by the manufacturers, was used. However, when the scale for the constriction was used, only 3% of the measurements were beyond the major foramen. Conclusion Electronic apex locators were able to determine the apical constriction. Using EAL s to determine the major foramen led to overestimation of the working length. Therefore, it may be recommended to use the EAL scale of the constriction.
Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities
2017-07-04

Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malaria transmission. P. falciparum at delivery was assessed by microscopy, quantitative PCR (qPCR) and placental histology in 946 HIV-uninfected and 768 HIV-infected pregnant women from Benin, Gabon, Kenya and Mozambique. Resistance was defined by the proportion of submicroscopic infections and the levels of anti-parasite antibodies quantified by Luminex, and tolerance by the relationship of pregnancy outcomes with parasite densities at delivery. P. falciparum prevalence by qPCR in peripheral and/or placental blood of HIV-uninfected Mozambican, Gabonese and Beninese women at delivery was 6% (21/340), 11% (28/257) and 41% (143/349), respectively. The proportion of peripheral submicroscopic infections was higher in Benin (83%) than in Mozambique (60%) and Gabon (55%; P = 0.033). Past or chronic placental P. falciparum infection was associated with an increased risk of preterm birth in Mozambican newborns (OR = 7.05, 95% CI 1.79 to 27.82). Microscopic infections were associated with reductions in haemoglobin levels at delivery among Mozambican women (-1.17 g/dL, 95% CI -2.09 to -0.24) as well as with larger drops in haemoglobin levels from recruitment to delivery in Mozambican (-1.66 g/dL, 95% CI -2.68 to -0.64) and Gabonese (-0.91 g/dL, 95% CI -1.79 to -0.02) women. Doubling qPCR-peripheral parasite densities in Mozambican women were associated with decreases in haemoglobin levels at delivery (-0.16 g/dL, 95% CI -0.29 to -0.02) and increases in the drop of haemoglobin levels (-0.29 g/dL, 95% CI -0.44 to -0.14). Beninese women had higher anti-parasite IgGs than Mozambican women (P &lt; 0.001). No difference was found in the proportion of submicroscopic infections nor in the adverse impact of P. falciparum infections in HIV-infected women from Kenya (P. falciparum prevalence by qPCR: 9%, 32/351) and Mozambique (4%, 15/417). The lowest levels of resistance and tolerance in pregnant women from areas of low malaria transmission were accompanied by the largest adverse impact of P. falciparum infections. Exposure-dependent mechanisms developed by pregnant women to resist the infection and minimise pathology can reduce malaria-related adverse outcomes. Distinguishing both types of defences is important to understand how reductions in transmission can affect malaria disease.
Cantonese Tone Perception for Children Who Use a Hearing Aid and a Cochlear Implant in Opposite Ears
2017-07-04

Objectives: The ability to recognize tones is vital for speech perception in tonal languages. Cantonese has six tones, which are differentiated almost exclusively by pitch cues (tones 1 to 6). The differences in pitch contours among the tones are subtle, making Cantonese a challenging language for cochlear implant users. The addition of a hearing aid has been shown to improve speech perception in nontonal languages and in Mandarin Chinese. This study (1) investigates the Cantonese tone perception ability of children who use a cochlear implant and a hearing aid in opposite ears; (2) evaluates the effect of varying pitch height and pitch contour cues on Cantonese tone perception for these children; and (3) compares the Cantonese tone perception ability for using a hearing aid and a cochlear implant together versus an implant alone. Design: Eight native Cantonese speaking children using a cochlear implant and a hearing aid in opposite ears were assessed for tone perception and word identification. The tone perception test involved discriminating and ranking tone pairs from natural and artificially manipulated Cantonese tones with various pitch heights and/or pitch contours. The word identification test involved identifying Cantonese words in a four-alternative forced-choice task. All tests were performed in two device conditions: (1) cochlear implant and hearing aid together and (2) implant alone. Results: Seven of the 8 subjects performed significantly above chance in both tests using the cochlear implant alone. Results showed that both pitch height and/or pitch direction were important perceptual cues for implant users. Perception for some tones was improved by increasing the pitch height differences between the tones. The ability to discriminate and rank the tone 2/tone 5 contrast and the tone 4/tone 6 contrast was poor, as the tones in these contrasts are similar in pitch contours and onset frequencies. No significant improvement was observed after artificially increasing the pitch offset differences between the tones in the tone 2/tone 5 and the tone 4/tone 6 contrasts. Tone perception results were significantly better with the addition of the hearing aid in the nonimplanted ear compared with using the implant alone; however, word identification results were not significantly different between using the implant alone and using both the hearing aid and the implant together. None of the subjects performed worse in tone perception or in word identification when the hearing aid was added. Conclusions: Reduced ability to perceive pitch contour cues, even when artificially exaggerated, may explain some of the difficulties in Cantonese word recognition for implant users. The addition of a contralateral hearing aid could be beneficial for Cantonese tone perception for some individuals with a unilateral implant. The results encouraged Cantonese speakers to trial a hearing aid in the nonimplanted ear when using a cochlear implant.
Quantifying the added value of convection-permitting climate simulations in complex terrain: a systematic evaluation of WRF over the Himalayas
2017-07-05

Abstract. Mesoscale dynamical refinements of global climate models or atmospheric reanalysis have shown their potential to resolve intricate atmospheric processes, their land surface interactions, and subsequently, realistic distribution of climatic fields in complex terrains. Given that such potential is yet to be explored within the central Himalayan region of Nepal, we investigate the skill of the Weather Research and Forecasting (WRF) model with different spatial resolutions in reproducing the spatial, seasonal, and diurnal characteristics of the near-surface air temperature and precipitation as well as the spatial shifts in the diurnal monsoonal precipitation peak over the Khumbu (Everest), Rolwaling, and adjacent southern areas. Therefore, the ERA-Interim (0.75°) reanalysis has been dynamically refined to 25, 5, and 1 km (D1, D2, and D3) for one complete hydrological year (October 2014–September 2015), using the one-way nested WRF model run with mild nudging and parameterized convection for the outer but explicitly resolved convection for the inner domains. Our results suggest that D3 realistically reproduces the monsoonal precipitation, as compared to its underestimation by D1 but overestimation by D2. All three resolutions, however, overestimate precipitation from the westerly disturbances, owing to simulating anomalously higher intensity of few intermittent events. Temperatures are generally reproduced well by all resolutions; however, winter and pre-monsoon seasons feature a high cold bias for high elevations while lower elevations show a simultaneous warm bias. Unlike higher resolutions, D1 fails to realistically reproduce the regional-scale nocturnal monsoonal peak precipitation observed in the Himalayan foothills and its diurnal shift towards high elevations, whereas D2 resolves these characteristics but exhibits a limited skill in reproducing such a peak on the river valley scale due to the limited representation of the narrow valleys at 5 km resolution. Nonetheless, featuring a substantial skill over D1 and D2, D3 simulates almost realistic shapes of the seasonal and diurnal precipitation and the peak timings even on valley scales. These findings clearly suggest an added value of the convective-scale resolutions in realistically resolving the topoclimates over the central Himalayas, which in turn allows simulating their interactions with the synoptic-scale weather systems prevailing over high Asia.
Nerve ultrasound as follow‐up tool in treated multifocal motor neuropathy
2017-07-05

Background and purpose High‐resolution ultrasound is a valuable tool in supporting the diagnosis of multifocal motor neuropathy ( MMN ) but longitudinal data under therapy are lacking. Methods The change in peripheral nerve ultrasound pattern in patients with MMN was assessed over time. Patients with MMN received a thorough initial examination and follow‐up over a period of 6–12 months using high‐resolution ultrasound of the cervical roots and the nerves of the arms and legs, nerve conduction studies, Medical Research Council Sum Score ( MRCSS ) and Rotterdam Inflammatory Neuropathy Cause and Treatment Group (INCAT ) score to evaluate changes under treatment. The Ultrasound Pattern Sum Score ( UPSS ) was used as standardized peripheral nerve ultrasound protocol. Results Seventeen patients with MMN received initial examinations of whom 12 were successfully followed up. All patients with MMN showed at least localized but often multifocal peripheral nerve enlargement. An enlarged overall cross‐sectional area as well as enlarged single fascicles (&gt;3 mm2) in clinically and electrophysiologically affected (&gt;90%) and unaffected (&gt;70%) nerves were found. The UPSS did not correlate with clinical disability at both visits. However, the change in clinical disability (evaluated as difference in MRCSS ) and the change in UPSS correlated significantly inversely ( P = 0.004). Conclusions High‐resolution sonography of peripheral nerves revealed multifocal nerve enlargement in MMN . Distinct enlargement patterns may support the diagnosis. Ultrasound findings did not correlate well with clinical severity or electrophysiological findings at initial presentation. As changes in UPSS correlated significantly with the clinical course in terms of muscle strength ( MRCSS ), sonographic assessment may represent a useful tool for therapeutic monitoring.
Gene family information facilitates variant interpretation and identification of disease-associated genes
2017-07-05

Abstract Differentiating risk-conferring from benign missense variants, and therefore optimal calculation of gene-variant burden, represent a major challenge in particular for rare and genetic heterogeneous disorders. While orthologous gene conservation is commonly employed in variant annotation, approximately 80% of known disease-associated genes are paralogs and belong to gene families. It has not been thoroughly investigated how gene family information can be utilized for disease gene discovery and variant interpretation. We developed a paralog conservation score to empirically evaluate whether paralog conserved or nonconserved sites of in-human paralogs are important for protein function. Using this score, we demonstrate that disease-associated missense variants are significantly enriched at paralog conserved sites across all disease groups and disease inheritance models tested. Next, we assessed whether gene family information could assist in discovering novel disease-associated genes. We subsequently developed a gene family de novo enrichment framework that identified 43 exome-wide enriched gene families including 98 de novo variant carrying genes in more than 10k neurodevelopmental disorder patients. 33 gene family enriched genes represent novel candidate genes which are brain expressed and variant constrained in neurodevelopmental disorders.
Isotropic-nematic transition for hard rods on a three-dimensional cubic lattice
2017-07-05

Using grand-canonical Monte Carlo (GCMC) simulations, we investigate the isotropic-nematic phase transition for hard rods of size L×1×1 on a three-dimensional cubic lattice. We observe such a transition for L≥6. For L=6, the nematic state has a negative order parameter, reflecting the co-occurrence of two dominating orientations. For L≥7, the nematic state has a positive order parameter, corresponding to the dominance of one orientation. We investigate rod lengths up to L=25 and find evidence for a very weakly first-order isotropic-nematic transition, while we cannot completely rule out a second-order transition. It was not possible to detect a density jump at the transition, despite using large systems containing several 10^{5} particles. The probability density distributions P(Q) from the GCMC simulations near the transition are very broad, pointing to strong fluctuations. Our results complement earlier results on the demixing (pseudonematic) transition for an equivalent system in two dimensions, which is presumably of Ising type and occurs for L≥7. We compare our results to lattice fundamental measure theory (FMT) and find that FMT strongly overestimates nematic order and consequently predicts a strong first-order transition. The rod packing fraction of the nematic coexisting states, however, agree reasonably well between FMT and GCMC.