julilili42/papers huggingface dataset:
Domain-specific prior knowledge and learning: A meta-analysis
2021-07-23

It is often hypothesized that prior knowledge strongly predicts learning performance. It can affect learning positively mediated through some processes and negatively mediated through others. We examined the relation between prior knowledge and learning in a meta-analysis of 8776 effect sizes. The stability of individual differences, that is, the correlation between pretest and posttest knowledge, was high (rP+ = .534). The predictive power of prior knowledge for learning, i.e., the correlation between pretest knowledge and normalized knowledge gains, was low (rNG+ = −.059), almost normally distributed, and had a large 95% prediction interval [–.688, .621]. This strong variability falsifies general statements such as “knowledge is power” as well as “the effect of prior knowledge is negligible.” It calls for systematic research on the conditions under which prior knowledge has positive, negative, or negligible effects on learning. This requires more experiments on the processes mediating the effects of prior knowledge and thresholds for useful levels of prior knowledge.
Strongly Red-Emissive Molecular Ruby [Cr(bpmp)2]3+ Surpasses [Ru(bpy)3]2+
2021-07-23

Gaining chemical control over the thermodynamics and kinetics of photoexcited states is paramount to an efficient and sustainable utilization of photoactive transition metal complexes in a plethora of technologies. In contrast to energies of charge transfer states described by spatially separated orbitals, the energies of spin-flip states cannot straightforwardly be predicted as Pauli repulsion and the nephelauxetic effect play key roles. Guided by multireference quantum chemical calculations, we report a novel highly luminescent spin-flip emitter with a quantum chemically predicted blue-shifted luminescence. The spin-flip emission band of the chromium complex [Cr(bpmp)2]3+ (bpmp = 2,6-bis(2-pyridylmethyl)pyridine) shifted to higher energy from ca. 780 nm observed for known highly emissive chromium(III) complexes to 709 nm. The photoluminescence quantum yields climb to 20%, and very long excited state lifetimes in the millisecond range are achieved at room temperature in acidic D2O solution. Partial ligand deuteration increases the quantum yield to 25%. The high excited state energy of [Cr(bpmp)2]3+ and its facile reduction to [Cr(bpmp)2]2+ result in a high excited state redox potential. The ligand’s methylene bridge acts as a Brønsted acid quenching the luminescence at high pH. Combined with a pH-insensitive chromium(III) emitter, ratiometric optical pH sensing is achieved with single wavelength excitation. The photophysical and ground state properties (quantum yield, lifetime, redox potential, and acid/base) of this spin-flip complex incorporating an earth-abundant metal surpass those of the classical precious metal [Ru(α-diimine)3]2+ charge transfer complexes, which are commonly employed in optical sensing and photo(redox) catalysis, underlining the bright future of these molecular ruby analogues.
Accuracy Evaluation of Additively and Subtractively Fabricated Palatal Plate Orthodontic Appliances for Newborns and Infants–An In Vitro Study
2021-07-23

Different approaches for digital workflows have already been presented for their use in palatal plates for newborns and infants. However, there is no evidence on the accuracy of CAD/CAM manufactured orthodontic appliances for this kind of application. This study evaluates trueness and precision provided by different CAM technologies and materials for these appliances. Samples of a standard palatal stimulation plate were manufactured using stereolithography (SLA), direct light processing (DLP) and subtractive manufacturing (SM). The effect of material (for SM) and layer thickness (for DLP) were also investigated. Specimens were digitized with a laboratory scanner (D2000, 3Shape) and analyzed with a 3D inspection software (Geomagic Control X, 3D systems). For quantitative analysis, differences between 3D datasets were measured using root mean square (RMS) error values for trueness and precision. For qualitative analysis, color maps were generated to detect locations of deviations within each sample. SM showed higher trueness and precision than AM technologies. Reducing layer thickness in DLP did not significantly increase accuracy, but prolonged manufacturing time. All materials and technologies met the clinically acceptable range and are appropriate for their use. DLP with 100 μm layer thickness showed the highest efficiency, obtaining high trueness and precision within the lowest manufacturing time.
Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
2021-07-23

Regular physical activity is an effective strategy to prevent and ameliorate aging-associated diseases. In particular, training increases muscle performance and improves whole-body metabolism. Since exercise affects the whole organism, it has countless health benefits. The systemic effects of exercise can, in part, be explained by communication between the contracting skeletal muscle and other organs and cell types. While small proteins and peptides known as myokines are the most prominent candidates to mediate this tissue cross-talk, recent investigations have paid increasing attention to metabolites. The purpose of this review is to highlight the potential role of tricarboxylic acid (TCA) metabolites as humoral mediators of exercise adaptation processes. We focus on TCA metabolites that are released from human skeletal muscle in response to exercise and provide an overview of their potential auto-, para- or endocrine health-promoting effects.
Exploiting lipotoxicity for the treatment of liver cancer
2021-07-23

Summary Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
Extreme fractionation of selenium isotopes and possible deep biospheric origin of platinum nuggets from Minas Gerais, Brazil
2021-07-23

Abstract Platinum-rich nuggets offer an opportunity for understanding how precious metals accumulate. We analyzed the selenium (Se) isotopic composition of Se-rich (102–103 μg g−1) platinum-palladium (Pt-Pd) nuggets from a recent placer deposit in Minas Gerais, Brazil, for which a biogenic origin has been inferred. We obtained Se isotopic values with a relatively narrow range (δ82/76SeNIST3149 = −17.4 to −15.4 ± 0.2, two standard deviations [2 SD]). The Pt-Os age of the nuggets is 181 ± 6 Ma (2 SD). The data indicate that the nuggets did not form in the recent placer deposit, but by replacement of hydrothermal vein minerals at ~70 °C and at least 800 m below the surface. The high abundance and extreme isotopic composition of Se as well as the presence of other biophilic elements like iodine, organic carbon, and nitrogen within the nugget matrix are consistent with a microbial origin. Although abiogenic reduction of Se oxyanions cannot be ruled out, the nuggets plausibly record Se-supported microbial activity in the deep biosphere.
Parental relationship quality and children's behavioural problems: Childcare quality as a protective factor?
2021-07-23

Objective: This study investigates how changes in parental relationship quality relate to children's socio-emotional development during early childhood and whether high-quality early childcare arrangements may act as a protective factor in children’s environments. Background: We draw on family systems theory and the bioecological model of human development to conceptualise how different social environments may interact in their influences on children's socio-emotional development during early childhood and across the transition to primary school. Method: Based on a pooled sample of 636 US-American children who took part in the longitudinal NICHD Study of Early Childcare and Youth Development (SECCYD), we applied fixed-effects panel models to three time points between age 3 and first grade. Results: Whereas changes in parental relationships quality were not significant in predicting children's socio-emotional development from age 3 to 4.5 years, our results showed that a reduction in parental relationship quality was moderately associated with an increase in behaviour problems of children across the transition to first grade. We did not find any evidence of mitigating effects of the child-specific process quality of the ECEC arrangement, neither for informal nor formal care settings. Conclusion: The results suggest that initiatives designed to improve a couple’'s relationship quality might also be an effective way to further their children’s socio-emotional development.
Quality of Life Following Urgent LVAD Implantation for ECMO Therapy in Cardiogenic Shock: A Long-Term Follow-Up
2021-07-24

Background and Objectives: Over the past decade, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has developed into a mainstream treatment for refractory cardiogenic shock (CS) to maximal conservative management. Successful weaning of VA-ECMO may not be possible, and bridging with further mechanical circulatory support (MCS), such as urgent implantation of a left ventricular assist device (LVAD), may represent the only means to sustain the patient haemodynamically. In the recovery phase, many survivors are not suitably prepared physically or psychologically for the novel issues encountered during daily life with an LVAD. Materials and Methods: A retrospective analysis of our institutional database between 2012 and 2019 was performed to identify patients treated with VA-ECMO for CS who underwent urgent LVAD implantation whilst on MCS. Post-cardiotomy cases were excluded. QoL was assessed prospectively during a routine follow-up visit using the EuroQol-5 dimensions-5 level (EQ-5D-5L) and the Patient Health Questionnaire (PHQ-9) surveys. Results: Among 126 in-hospital survivors of VA-ECMO therapy due to cardiogenic shock without prior cardiac surgery, 31 (24.6%) urgent LVAD recipients were identified. In 11 (36.7%) cases, cardiopulmonary resuscitation (CPR) was performed (median 10, range 1–60 min) before initiation of VA-ECMO, and in 5 (16.7%) cases, MCS was established under CPR. Mean age at LVAD implantation was 51.7 (+/−14) years and surgery was performed after a mean 12.1 (+/−8) days of VA-ECMO support. During follow-up of 46.9 (+/−25.5) months, there were 10 deaths after 20.4 (+/−12.1) months of LVAD support. Analysis of QoL questionnaires returned a mean EQ-5D-5L score of 66% (+/−21) of societal valuation for Germany and a mean PHQ-9 score of 5.7 (+/−5) corresponding to mild depression severity. When compared with 49 elective LVAD recipients without prior VA-ECMO therapy, there was no significant difference in QoL results. Conclusions: Patients requiring urgent LVAD implantation under VA-ECMO support due to CS are associated with comparable quality of life without a significant difference from elective LVAD recipients. Close follow-up is required to oversee patient rehabilitation after successful initial treatment.
Systematic Evaluation of Geometry‐Driven Lateral River‐Groundwater Exchange in Floodplains
2021-07-24

Abstract The widening and narrowing of river‐valley aquifers can cause valley‐scale lateral hyporheic exchange even if the river is straight and its slope is uniform. For the aforementioned system, we derive a semi‐analytical solution describing steady‐state groundwater flow for a simplified two‐dimensional geometry of the aquifer and uniform lateral influx from hillslopes. We use this solution to evaluate the geometry‐driven lateral hyporheic exchange flux between the aquifer and the river. By systematically varying the model parameters, we decipher how this flux and the area of the exchange zone depend on geometric (e.g., minimum and maximum domain width) and hydrogeological parameters (e.g., hydraulic conductivity, ambient hydraulic gradient and lateral influxes). The results suggest pronounced hyporheic flow for cases with distinct widening behavior and small cross‐sectional widths at the floodplain inlet and outlet. Furthermore, we analyze the travel‐time distribution of water flowing through the exchange zone, which approximately follows a beta distribution. We express our findings in terms of simple proxy‐equations that can be used to easily estimate the exchange flux, the area of the exchange zone, and the associated travel‐time distribution for a given geographic/landscape setting.
The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection
2021-07-24

ABSTRACT Human Nogo-66 receptor 1 (NgR1) is a receptor for mammalian orthoreoviruses (reoviruses), but the mechanism of virus-receptor engagement is unknown. NgR1 binds a variety of structurally dissimilar ligands in the adult central nervous system (CNS) to inhibit axon outgrowth. Disruption of ligand binding to NgR1 and subsequent signaling can improve neuron regrowth, making NgR1 an important therapeutic target for diverse conditions such as spinal crush injuries and Alzheimer disease. To elucidate how NgR1 mediates cell binding and entry of reovirus, we defined the affinity of interaction between virus and receptor, determined the structure of the virus-receptor complex, and identified residues in the receptor required for virus binding and infection. These studies revealed that NgR1 sequences in a central concave region of the molecule establish a bridge between two copies of the viral capsid protein, σ3. This unusual binding interface produces high-avidity interactions between virus and receptor and likely primes early entry steps. NgR1 sequences engaged by reovirus also are required for NgR1 binding to ligands expressed by neurons and oligodendrocytes. These studies redefine models of reovirus cell-attachment and highlight the evolution of viruses to engage multiple receptors using distinct capsid components.
Trait-trait relationships and tradeoffs vary with genome size in prokaryotes
2021-07-24

Abstract We report genomic traits that have been associated with the life history of prokaryotes and highlight conflicting findings concerning earlier observed trait correlations and tradeoffs. In order to address possible explanations for these contradictions we examined trait-trait variations of 11 genomic traits from ~ 18,000 sequenced genomes. The studied trait-trait variations suggested: (i) the predominance of two resistance and resilience-related orthogonal axes and (ii) at least in free living species with large effective population sizes whose evolution is little affected by genetic drift an overlap between a resilience axis and an axis of resource usage efficiency. These findings imply that resistance associated traits of prokaryotes are globally decoupled from resilience related traits and in the case of free-living communities also from resource use efficiencies associated traits. However, further inspection of pairwise scatterplots showed that resistance and resilience traits tended to be positively related for genomes up to roughly five million base pairs and negatively for larger genomes. This in turn may preclude a globally consistent assignment of prokaryote genomic traits to the competitor - stress-tolerator - ruderal (CSR) schema that sorts species depending on their location along disturbance and productivity gradients into three ecological strategies and may serve as an explanation for conflicting findings from earlier studies. All reviewed genomic traits featured significant phylogenetic signals and we propose that our trait table can be applied to extrapolate genomic traits from taxonomic marker genes. This will enable to empirically evaluate the assembly of these genomic traits in prokaryotic communities from different habitats and under different productivity and disturbance scenarios as predicted via the resistance-resilience framework formulated here.
The origins of goals in the German Bundesliga
2021-07-25

We propose to analyse the origin of goals in professional football (soccer) in a purely data-driven approach. Based on positional and event data of 3,457 goals from two seasons German Bundesliga and 2nd Bundesliga (2018/20,219 and 2019/2020), we devise a rich set of 37 features that can be extracted automatically and propose a hierarchical clustering approach to identify group structures. The results consist of 50 interpretable clusters revealing insights into scoring patterns. The hierarchical clustering found 8 alone standing clusters (penalties, direct free kicks, kick and rush, one-two's, assisted by header, assisted by throw-in) and nine categories (e.g., corners) combining more granular patterns (e.g., five subcategories of corner-goals). We provide a thorough discussion of the clustering and show its relevance for practical applications in opponent analysis, player scouting and for long-term investigations. All stages of this work have been supported by professional analysts from clubs and federation.
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
2021-07-26

While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process may be controlled by cellular receptors of α-synuclein fibrils, one of which was proposed to be the LAG3 immune checkpoint molecule. Here, we analysed the expression pattern of LAG3 in human and mouse brains. Using a variety of methods and model systems, we found no evidence for LAG3 expression by neurons. While we confirmed that LAG3 interacts with α-synuclein fibrils, the specificity of this interaction appears limited. Moreover, overexpression of LAG3 in cultured human neural cells did not cause any worsening of α-synuclein pathology ex vivo. The overall survival of A53T α-synuclein transgenic mice was unaffected by LAG3 depletion, and the seeded induction of α-synuclein lesions in hippocampal slice cultures was unaffected by LAG3 knockout. These data suggest that the proposed role of LAG3 in the spreading of α-synucleinopathies is not universally valid.
Vertical Zoning in Hydrothermal U-Ag-Bi-Co-Ni-As Systems: A Case Study from the Annaberg-Buchholz District, Erzgebirge (Germany)
2021-07-26

Abstract The Annaberg-Buchholz district is a classic occurrence of hydrothermal five-element (U-Ag-Bi-Co-Ni-As) veins in the Erzgebirge (Germany) with an historic production of ~8,700 metric tons (t) Co ore, 496 t U ore, and 26.9 t Ag. Multiple mineralization stages are recognized in polyphase veins hosted by Proterozoic paragneiss. Fluorite-barite-Pb-Zn mineralization occurs across the entire vertical profile of the district, whereas U and five-element stages are restricted to the upper 400 m below surface, coinciding with a graphite-rich gneiss lithology. Here, we present field and petrographic observations, electron probe microanalysis and fluid inclusion data, as well as thermodynamic calculations to characterize five-element and fluorite-barite-Pb-Zn associations, and to constrain the origin of the vertical zoning in the Annaberg-Buchholz district. Microthermometric analyses of fluid inclusions related to the fluorite-barite-Pb-Zn stage yield homogenization temperatures between 78° and 140°C and salinities between 21.9 and 27.7 equiv wt % (NaCl-CaCl2). A correlation of fluid inclusion Na/ (Na + Ca) ratios with salinity suggests fluid mixing as a likely precipitation mechanism and relates ore formation tentatively to regional tectonics of the Mesozoic opening of the Atlantic. Thermodynamic calculations indicate that U is more sensitive to reduction than As, predicting that arsenide minerals are precipitated more distally relative to uraninite upon reduction along the fluid-flow path. This implies that the observed vertical zoning is not a primary feature but is the result of hydrothermal remobilization. The observations made in the Annaberg-Buchholz district have general importance to the understanding of U-rich five-element mineralization and may be relevant for exploration targeting in unconformity-related U deposits.
Constraining the Konoplya-Rezzolla-Zhidenko deformation parameters: Limits from supermassive black hole x-ray data
2021-07-26

X-ray reflection spectroscopy is a powerful technique for probing the nature of gravity around black holes in the so-called strong field regime. One of the most popular of such probes is to look at theory-agnostic deviations away from the Kerr solution, which is the only astrophysically relevant black hole solution within classical general relativity, in order to verify whether astrophysical black holes are described by the Kerr metric. We have recently extended our X-ray reflection spectroscopy framework to a class of very general axisymmetric non-Kerr black holes proposed by Konoplya, Rezzolla & Zhidenko (Phys. Rev. D93, 064015, 2016). Here, we analyze XMM-Newton and NuSTAR observations of the supermassive black hole in the Seyfert 1 galaxy MCG-06-30-15 with six different deviation parameters of this extended model. We recover the Kerr solution in all cases, but some deformation parameters are poorly constrained. We discuss the implications of this verification and future possibilities.
A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options
2021-07-26

Abstract Objectives Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of only six months without therapy, which requires a better understanding of PM biology and new treatment strategies. Methods We established and characterized a human ex vivo peritoneal model to investigate the mechanisms of peritoneal seeding and possible treatment options. For this, CRC cell lines and patient-derived tumor organoids were cultured together with human peritoneum to investigate the invasion of malignant cells and the effects of local chemotherapy. Results Fresh human peritoneum was cultured for up to three weeks in a stainless steel ring system, allowing for survival of all peritoneal structures. Peritoneal cell survival was documented by light microscopy and immunohistochemical staining. Further, immunohistological characterization of the tissue revealed CD3-positive T-lymphocytes and vimentin-positive fibroblasts within the peritoneum. In addition, extracellular matrix components (collagens, matrix metalloproteinases) were localized within the tissue. Coculture with CRC cell lines and patient-derived CRC organoids revealed that cancer cells grew on the peritoneum and migrated into the tissue. Coculture with CRC cells confirmed that hyperthermal treatment at 41 °C for 90 min significantly enhanced the intracellular entry of doxorubicin. Moreover, treatment with mitomycin C under hyperthermic conditions significantly reduced the amount of cancer cells within the peritoneum. Conclusions This human ex vivo peritoneal model provides a stringent and clinically relevant platform for the investigation of PM and for further elucidation of possible treatment options.
Efficacy and safety of Zi Gui Nv Zhen® capsules used in TCM for fertility preservation in patients with diminished ovarian reserve
2021-07-26

In women with DOR who wish to conceive, three months' application of ZGNZC can improve ovarian function and oocyte quality by adjusting the neuroendocrine system, can improve endometrial properties and proliferation, necessary for a healthy pregnancy, and increased the clinical pregnancy rate in our prospective randomized observational study.