julilili42/papers huggingface dataset:
Translating resilience research to political practice – The case of the German Resilience Strategy
2024-08-03

There is a gap between research in disaster resilience and the implementation of resilience via political strategies. This paper uses three frameworks from resilience research to analyse the 2022 German Resilience Strategy as a case study. It answers two questions: Does the German Resilience Strategy reflect resilience understandings from research and what are its strengths and shortcomings? Are such resilience frameworks useful for analysing political documents and what are their strengths and shortcomings? The resilience frameworks are Bruneau et al.'s 4Rs of resilience, Hollnagel's four cornerstones of resilience, and Thoma et al.'s resilience cycle. The paper uses qualitative content analysis to interpret the 345 recommendations for measures of the Strategy. The results show that the Strategy lives up to a holistic definition of resilience. It implicitly also embraces a complexity-informed understanding of resilience, but risks losing sight on adaptive capacity due to its broadness. The Strategy focuses on natural hazards, although it officially follows the all-hazard approach. There is a lack of recommendations on individual and societal disaster recovery. The three resilience frameworks are applicable for analysing political strategies. The 4Rs of resilience framework has a blind spot with respect to unknown disruptions. The four cornerstones of resilience framework bases on an innovative resilience conception and could be useful for disaster studies if it was more thoroughly translated to the latter's specifics. The resilience cycle framework is limited due to its cyclical approach, and it entails prevention, which is not part of resilience.
Evaluation of a medical student-delivered smoking prevention program utilizing a face-aging mobile app for secondary schools in Germany: The Education Against Tobacco cluster-randomized controlled trial
2024-08-03

While a trend towards beneficial effects of the intervention regarding smoking prevalence as well as intention to start smoking among baseline non-smokers was observed, our smoking prevention trial demonstrated no significant effect of the intervention.
Tailoring Co‐Free LiNi0.5Mn1.5O4 Material for High‐Voltage Lithium‐Ion Batteries: Particle Design & Grain Boundary Engineering
2024-08-04

Abstract Cobalt‐free LiNi 0.5 Mn 1.5 O 4 (LNMO) is a promising cathode material for high‐energy and power‐density lithium‐ion batteries (LIBs). However, its commercial adoption is hindered by rapid capacity degradation due to the unstable LNMO/electrolyte interface caused by LNMO's high operating voltage. Structural degradation from Jahn–Teller distortion and metal‐ion dissolution also contributes to poor cycling stability. Additionally, producing industrial‐grade LNMO with high tap density, low surface area and reduced metal‐ion dissolution is challenging. This study addresses these challenges through a rational material design approach, synthesizing LNMO with large spherical secondary particles (&gt;14.0 μm) and high tap density (&gt;2.0 g cm −3 ). The primary particles (1.5–6.0 μm) exhibit a truncated‐octahedral shaped morphology that predominantly exposes (111) surface facets, with fewer (100) surfaces, stabilizing the LNMO/electrolyte interface, reducing metal dissolution, and enhancing lithium‐ion kinetics. Silicon infusion into grain boundaries further improves structural integrity by forming a silicon‐rich phase. The tailored LNMO demonstrates exceptional rate capability, cycling stability, and improved interfacial kinetics, significantly advancing the potential for cobalt‐free LNMO in high‐voltage LIBs. This work highlights the importance of tailored cathode material design for achieving the performance and stability required for emerging high‐voltage LIBs applications.
Teaming Up with an AI: Exploring Human–AI Collaboration in a Writing Scenario with ChatGPT
2024-08-05

Recent advancements in artificial intelligence (AI) technologies, particularly in generative pre-trained transformer large language models, have significantly enhanced the capabilities of text-generative AI tools—a development that opens new avenues for human–AI collaboration across various domains. However, the dynamics of human interaction with AI-based chatbots, such as ChatGPT, remain largely unexplored. We observed and analyzed how people interact with ChatGPT in a collaborative writing setting to address this research gap. A total of 135 participants took part in this exploratory lab study, which consisted of engaging with ChatGPT to compose a text discussing the prohibition of alcohol in public in relation to a given statement on risky alcohol consumption. During the writing task, all screen activity was logged. In addition to the writing task, further insights on user behavior and experience were gained by applying questionnaires and conducting an additional short interview with a randomly selected subset of 18 participants. Our results reveal high satisfaction with ChatGPT regarding quality aspects, mainly cognitive rather than affect-based trust in ChatGPT’s responses, and higher ratings on perceived competence than on warmth. Compared to other types of prompts, mostly content-related prompts for data, facts, and information were sent to ChatGPT. Mixed-method analysis showed that affinity for technology integration and current use of ChatGPT were positively associated with the frequency of complete text requests. Moreover, prompts for complete texts were associated with more copy–paste behavior. These first insights into co-writing with ChatGPT can inform future research on how successful human–AI collaborative writing can be designed.
Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants
2024-08-05

Importance The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified. Objective To examine the efficacy of Bifidobacterium longum subsp infantis , Bifidobacterium animalis subsp lactis (BB-12), and Lactobacillus acidophilus (La-5) probiotics to prevent colonization with multidrug-resistant organisms or highly epidemic bacteria (MDRO+) and to shape the microbiome of preterm infants toward the eubiotic state of healthy full-term infants. Design, Setting, and Participants The multicenter, double-blinded, placebo-controlled, group sequential, phase 3 Priming Immunity at the Beginning of Life (PRIMAL) randomized clinical trial, conducted from April 2018 to June 2020, included infants with gestational age of 28 to 32 weeks at 18 German neonatal units. Data analyses were conducted from March 2020 to August 2023. Intervention A total of 28 days of multistrain probiotics diluted in human milk/formula starting within the first 72 hours of life. Main Outcomes and Measures Colonization with MDRO+ at day 30 of life (primary end point), late-onset sepsis and severe gastrointestinal complication (safety end points), and gut dysbiosis, ie, deviations from the microbiome of healthy, term infants (eubiosis score) based on 16-subunit ribosomal RNA and metagenomic sequencing. Results Among the 643 infants randomized until the stop of recruitment based on interim results, 618 (median [IQR] gestational age, 31.0 [29.7-32.1] weeks; 333 male [53.9%]; mean [SD] birth weight, 1502 [369] g) had follow-up at day 30. The interim analysis with all available data from 219 infants revealed MDRO+ colonization in 43 of 115 infants (37.4%) in the probiotics group and in 39 of 104 infants (37.5%) in the control group (adjusted risk ratio, 0.99; 95% CI, 0.54-1.81; P = .97). Safety outcomes were similar in both groups, ie, late-onset sepsis (probiotics group: 8 of 316 infants [2.5%]; control group: 12 of 322 infants [3.7%]) and severe gastrointestinal complications (probiotics group: 6 of 316 infants [1.9%]; control group: 7 of 322 infants [2.2%]). The probiotics group had higher eubiosis scores than the control group at the genus level (254 vs 258 infants; median scores, 0.47 vs 0.41; odds ratio [OR], 1.07; 95% CI, 1.02-1.13) and species level (96 vs 83 infants; median scores, 0.87 vs 0.59; OR, 1.28; 95% CI, 1.19-1.38). Environmental uptake of the B infantis probiotic strain in the control group was common (41 of 84 [49%]), which was highly variable across sites and particularly occurred in infants with a sibling who was treated with probiotics. Conclusions and Relevance Multistrain probiotics did not reduce the incidence of MDRO+ colonization at day 30 of life in preterm infants but modulated their microbiome toward eubiosis. Trial Registration German Clinical Trials Register: DRKS00013197
Phylogenetic nomenclature of Notosuchia (Crocodylomorpha; Crocodyliformes)
2024-08-05

Notosuchia is a large and diverse clade of Mesozoic crocodyliforms that thrived in continental environments especially during the Cretaceous of Gondwana. This clade has been the focus of several phylogenetic studies that led to the consensus of two main topological arrangements, mostly differing in the position of the clade Sebecidae: the sebecosuchian and sebecian hypotheses. In this manuscript we review the main phylogenetic definitions of several clades of notosuchians in the context of these hypotheses. As a result, besides the clade names previously established under the ICPN/Phylocode (including registration in RegNum) by Ruiz et al. (2021) (Notosuchia, Xenodontosuchia, Sphagesauria, Sphagesauridae) and Darlim et al. (2021a) (Baurusuchia, Baurusuchidae, Baurusuchinae, Pissarrachampsinae), eleven clade names have been registered and are defined in this contribution. Ten of these represent converted clade names (Uruguaysuchidae, Mahajangasuchidae, Peirosauridae, Itasuchidae, Ziphosuchia, Sphagesaurinae, Caipirasuchinae, Sebecia, Sebecosuchia, and Sebecia), while one represents a new clade name (Peirosauria). Furthermore, the definition of Xenodontosuchia is emended (unrestricted emendation) so that the name can be used in the context of a wider array of topologies.
An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification
2024-08-05

Abstract RNA base editing relies on the introduction of adenosine-to-inosine changes into target RNAs in a highly programmable manner in order to repair disease-causing mutations. Here, we propose that RNA base editing could be broadly applied to perturb protein function by removal of regulatory phosphorylation and acetylation sites. We demonstrate the feasibility on more than 70 sites in various signaling proteins and identify key determinants for high editing efficiency and potent down-stream effects. For the JAK/STAT pathway, we demonstrate both, negative and positive regulation. To achieve high editing efficiency over a broad codon scope, we applied an improved version of the SNAP-ADAR tool. The transient nature of RNA base editing enables the comparably fast (hours to days), dose-dependent (thus partial) and reversible manipulation of regulatory sites, which is a key advantage over DNA (base) editing approaches. In summary, PTM interference might become a valuable field of application of RNA base editing.
Comparative analysis of FDA approvals by top 20 pharma companies (2014–2023)
2024-08-05

This article addresses the research and development (R&D) productivity challenge of the pharmaceutical industry, focusing on United States Food and Drug Administration (FDA)-related new drug approvals of the top 20 pharmaceutical companies (2014-2023). We evaluated the degree of innovation in new drugs to determine the innovativeness of these leading companies. A key finding of our analysis is the decline in the number of new drugs approved by the FDA for these leading companies over the investigated time period. This trend suggests that some of the leading companies are losing ground in R&D innovation, raising concerns about their ability to sustain competitive advantage, ensure long-term market success, and maintain viable business models.
Slack K+ channels confer protection against myocardial ischaemia/reperfusion injury
2024-08-05

Abstract Aims Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellular Na+ concentration ([Na+]i) reaches pathophysiological levels. Elevated [Na+]i is a major determinant of the ischaemia and reperfusion (I/R)-induced myocardial injury; thus, we hypothesized that Slack plays a role under these conditions. Methods and results K+ currents in cardiomyocytes (CMs) obtained from wildtype but not from global Slack knockout mice were sensitive to electrical inactivation of voltage-sensitive Na+ channels. Live-cell imaging demonstrated that K+ fluxes across the sarcolemma rely on Slack, while the depolarized resting membrane potential in Slack-deficient CMs led to excessive cytosolic Ca2+ accumulation and finally to hypoxia/reoxygenation-induced cell death. Cardiac damage in an in vivo model of I/R was exacerbated in global and CM-specific conditional Slack mutants and largely insensitive to mechanical conditioning manoeuvres. Finally, the protection conferred by mitochondrial ATP-sensitive K+ (mitoKATP) channels required functional Slack in CMs. Conclusion Collectively, our study provides evidence for Slack's crucial involvement in the ion homeostasis of no or low O2-stressed CMs. Thereby, Slack activity opposes the I/R-induced fatal Ca2+-uptake to CMs supporting the cardioprotective signaling attributed to mitoKATP function.
Disparity of turbinal bones in placental mammals
2024-08-05

Abstract Turbinals are key bony elements of the mammalian nasal cavity, involved in heat and moisture conservation as well as olfaction. While turbinals are well known in some groups, their diversity is poorly understood at the scale of placental mammals, which span 21 orders. Here, we investigated the turbinal bones and associated lamellae for one representative of each extant order of placental mammals. We segmented and isolated each independent turbinal and lamella and found an important diversity of variation in the number of turbinals, as well as their size, and shape. We found that the turbinal count varies widely, from zero in the La Plata dolphin, ( Pontoporia blainvillei ) to about 110 in the African bush elephant ( Loxodonta africana ). Multiple turbinal losses and additional gains took place along the phylogeny of placental mammals. Some changes are clearly attributed to ecological adaptation, while others are probably related to phylogenetic inertia. In addition, this work highlights the problem of turbinal nomenclature in some placental orders with numerous and highly complex turbinals, for which homologies are extremely difficult to resolve. Therefore, this work underscores the importance of developmental studies to better clarify turbinal homology and nomenclature and provides a standardized comparative framework for further research.
Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer
2024-08-05

Objective/Background: Various anastomotic and reconstruction techniques are used for minimally invasive total (miTG) and distal gastrectomy (miDG). Their effects on postoperative morbidity have not been extensively studied. Methods: MiTG and miDG patients were selected from 9356 oncological gastrectomies performed in 2017–2021 in 43 centers. Endpoints included anastomotic leakage (AL) rate and postoperative morbidity tested by multivariable analysis. Results: Three major anastomotic techniques [circular stapled (CS); linear stapled (LS); and hand sewn (HS)], and 3 major bowel reconstruction types [Roux (RX); Billroth I (BI); Billroth II (BII)] were identified in miTG (n=878) and miDG (n=3334). Postoperative complications, including AL (5.2% vs 1.1%), overall (28.7% vs 16.3%), and major morbidity (15.7% vs 8.2%), as well as 90-day mortality (1.6% vs 0.5%) were higher after miTG compared with miDG. After miTG, the AL rate was higher after CS (4.3%) and HS (7.9%) compared with LS (3.4%). Similarly, major complications (LS: 9.7%, CS: 16.2%, and HS: 12.7%) were lowest after LS. Multivariate analysis confirmed anastomotic technique as a predictive factor for AL, overall, and major complications. In miDG, AL rate (BI: 1.4%, BII 0.8%, and RX 1.2%), overall (BI: 14.5%, BII: 15.0%, and RX: 18.7%), and major morbidity (BI: 7.9%, BII: 9.1%, and RX: 7.2%), and mortality (BI: 0%, BII: 0.1%, and RY: 1.1%%) were not affected by bowel reconstruction. Conclusions: In oncologically suitable situations, miDG should be preferred to miTG, as postoperative morbidity is significantly lower. LS should be a preferred anastomotic technique for miTG in Western Centers. Conversely, bowel reconstruction in DG may be chosen according to the surgeon’s preference.
Mechanical Implications of Cellular Viscoelasticity, Cortex Polarity, Superelasticity, and Cell-Cell Junctions in Curved Tissues
2024-08-05

ABSTRACT Investigations of the response of curved epithelia derived from MDCK-II cells to external deformation involved indentation-relaxation experiments using colloidal probe microscopy. Notably, hemicysts exhibited lower tissue tension, greater compliance, and increased fluidity compared to cysts. The primary response to deformation turned out to be the in-plane expansion of the basal cortex/membrane of cells. Additionally, drug treatments applied to curved tissue, along with deformation of tailored mutants (such as E-cadherin knockout), revealed that tissue compliance over short time scales is influenced by an interplay of viscoelastic properties in individual cells, their apical-basal polarity, superelasticity of the shell, and excess interfacial area. Meanwhile, tissue resilience predominantly depends on the integrity of cell-cell contacts.
Nonequilibrium Transition between Dissipative Time Crystals
2024-08-06

We show a dissipative phase transition in a driven nonlinear quantum oscillator in which a discrete time-translation symmetry is spontaneously broken in two different ways. The corresponding regimes display either discrete or incommensurate time-crystal order, which we analyze numerically and analytically beyond the classical limit, addressing observable dynamics, phenomenology in different (laboratory and rotating) frames, Liouvillian spectral features, and quantum fluctuations. Via an effective semiclassical description, we show that phase diffusion dominates in the incommensurate time crystal (or continuous time crystal in the rotating frame), which manifests as a band of eigenmodes with a lifetime growing linearly with the mean-field excitation number. Instead, in the discrete time-crystal phase, the leading fluctuation process corresponds to quantum activation with a single mode that has an exponentially growing lifetime. Interestingly, the transition between these two regimes manifests itself already in the quantum regime as a spectral singularity, namely, as an exceptional point mediating between phase diffusion and quantum activation. Finally, we discuss this transition between different time-crystal orders in the context of synchronization phenomena. Published by the American Physical Society 2024
Cardiac cycle modulates social pain
2024-08-06

Social pain is a painful feeling evoked by social rejection, exclusion, or the loss of other important people. Previous research suggests that physical pain is reduced by increased signals from baroreceptors that monitor blood pressure. This pre-registered study investigated whether social pain is attenuated by increased baroafferent signals, as observed in physical pain. Given that baroafferent signals increase during cardiac systole and decrease during diastole, we hypothesized that feelings of pain induced by social rejection would be lower when exclusion events are presented at the cardiac systole than when they are presented at the diastole. Participants completed the cyberball task, a computerized ball-tossing game involving two other players. In the rejection condition, the ball was rarely thrown to the participant, while the other players kept tossing it to each other. Throws between other players were defined as exclusion events and were presented either at the cardiac systole (a systole condition) or at the diastole (a diastole condition). We found that exclusion events evoked significantly less social pain in the systole condition than in the diastole condition. Furthermore, the effects of cardiac cycle were more pronounced in participants with higher heart rate variability than those with lower heart rate variability. Our results suggest that cardiac afferent signals contribute not only to physical pain but also to social pain.
Spatial Prediction of Organic Matter Quality in German Agricultural Topsoils
2024-08-06

Soil organic matter (SOM) and the ratio of soil organic carbon to total nitrogen (C/N ratio) are fundamental to the ecosystem services provided by soils. Therefore, understanding the spatial distribution and relationships between the SOM components mineral-associated organic matter (MAOM), particulate organic matter (POM), and C/N ratio is crucial. Three ensemble machine learning models were trained to obtain spatial predictions of the C/N ratio, MAOM, and POM in German agricultural topsoil (0–10 cm). Parameter optimization and model evaluation were performed using nested cross-validation. Additionally, a modification to the regressor chain was applied to capture and interpret the interactions among the C/N ratio, MAOM, and POM. The ensemble models yielded mean absolute percent errors (MAPEs) of 8.2% for the C/N ratio, 14.8% for MAOM, and 28.6% for POM. Soil type, pedo-climatic region, hydrological unit, and soilscapes were found to explain 75% of the variance in MAOM and POM, and 50% in the C/N ratio. The modified regressor chain indicated a nonlinear relationship between the C/N ratio and SOM due to the different decomposition rates of SOM as a result of variety in its nutrient quality. These spatial predictions enhance the understanding of soil properties’ distribution in Germany.
Multilateral tax treaty revision to combat tax avoidance: on the merits and limits of BEPS’s multilateral instrument
2024-08-06

Summary Since 2015, more than 140 countries have cooperated in the OECD’s ‘Base Erosion and Profit Shifting’ (BEPS) project to combat multinational tax avoidance. Several of the key actions, most importantly measures against tax treaty shopping, require changes to double taxation treaties. The OECD designed a special instrument – the ‘multilateral instrument’ (MLI) – to allow for a swift implementation of BEPS-related tax treaty changes. In this paper, we show that MLI take-up is incomplete, and we present (partly surprising) correlates of the take-up decision and develop a simple theoretical model to rationalize the observed take-up behaviour. A key insight is that conduit countries, which are the beneficiaries of tax treaty shopping, can benefit from anti-treaty shopping laws as firms have incentives to scale-up real activity in conduit nations in order to be exempted from the new anti-treaty shopping rules. Empirical findings are consistent with these considerations: MLI adoption rates of conduit countries are high. Treaty shopping has, to date, not significantly dropped. And there is indeed indication that firms have scaled up their real economic activity in conduit nations. Overall, our findings reject that treaty shopping has been ‘killed’ as envisaged by the OECD.