julilili42/papers huggingface dataset:
Microwave to optical conversion with atoms on a superconducting chip
2019-07-01

Abstract We describe a scheme to coherently convert a microwave photon of a superconducting co-planar waveguide resonator to an optical photon emitted into a well-defined temporal and spatial mode. The conversion is realized by a cold atomic ensemble trapped close the surface of the superconducting atom chip, near the antinode of the microwave cavity. The microwave photon couples to a strong Rydberg transition of the atoms that are also driven by a pair of laser fields with appropriate frequencies and wavevectors for an efficient wave-mixing process. With only several thousand atoms in an ensemble of moderate density, the microwave photon can be completely converted into an optical photon emitted with high probability into the phase matched direction and, e.g. fed into a fiber waveguide. This scheme operates in a free-space configuration, without requiring strong coupling of the atoms to a resonant optical cavity.
Role of information backflow in the emergence of quantum Darwinism
2019-07-01

Quantum Darwinism attempts to explain the emergence of objective reality of the state of a quantum system in terms of redundant information about the system acquired by independent noninteracting fragments of the environment. The consideration of interacting environmental elements gives rise to a rich phenomenology, including the occurrence of non-Markovian features, whose effects on objectification in the manner of quantum Darwinism needs to be fully understood. We study a model of local interaction between a simple quantum system and a multimode environment that allows for a clear investigation of the interplay between information trapping and propagation in the environment and the emergence of quantum Darwinism. We provide strong evidence of the correlation between non-Markovianity and quantum Darwinism in such a model, thus providing strong evidence of a potential link between such fundamental phenomena.
Insight-HXMT Observations of Swift J0243.6+6124 during Its 2017–2018 Outburst
2019-07-01

Abstract The recently discovered neutron star transient Swift J0243.6+6124 has been monitored by the Hard X-ray Modulation Telescope . Based on the obtained data, we investigate the broadband spectrum of the source throughout the outburst. We estimate the broadband flux of the source and search for possible cyclotron line in the broadband spectrum. However, no evidence of line-like features is found up to 150 keV. In the absence of any cyclotron line in its energy spectrum, we estimate the magnetic field of the source based on the observed spin evolution of the neutron star by applying two accretion torque models. In both cases, we get consistent results with B ∼ 10 13 G, D ∼ 6 kpc and peak luminosity of &gt;10 39 erg s −1 , which makes the source the first Galactic ultraluminous X-ray source hosting a neutron star.
High-speed path following control of skid-steered vehicles
2019-07-01

We present a robust control scheme for skid-steered vehicles that enables high-speed path following on challenging terrains. First, a kinematic model with experimentally identified parameters is constructed to describe the terrain-dependent motion of skid-steered vehicles. Using Lyapunov theory, a nonlinear control law is defined, guaranteeing the convergence of the vehicle to the path. To allow smooth and accurate motion at higher speeds, an additional linear velocity control scheme is proposed, which takes actuator saturation, path following error, and reachable curvatures into account. The combined solution is experimentally evaluated and compared against two state-of-the-art algorithms, by using two different robots on several different terrain types, at different speeds. A Robotnik Summit XL robot is tested on three different terrain types and two different paths at speeds up to [Formula: see text] m/s. A Segway RMP 440 robot is tested on three different terrain types and two different path types at speeds up to [Formula: see text] m/s.
Smart but Evil? Student-Teachers’ Perception of Educational Researchers’ Epistemic Trustworthiness
2019-07-01

In-service and preservice teachers are increasingly required to integrate research results into their classroom practice. However, due to their limited methodological background knowledge, they often cannot evaluate scientific evidence firsthand and instead must trust the sources on which they rely. In two experimental studies, we investigated the amount of this so-called epistemic trustworthiness (dimensions expertise, integrity, and benevolence) that student-teachers ascribe to the authors of texts who present classical research findings (e.g., learning with worked-out examples) that allegedly were written by a practitioner, an expert, or a scientist. Results from the first exploratory study suggest that student-teachers view scientists as “smart but evil,” since they rate them as having substantially more expertise than practitioners, while also being less benevolent and lacking in integrity. Moreover, results from the exploratory study suggest that evaluativistic epistemic beliefs (beliefs about the nature of knowledge) predict epistemic trustworthiness. A preregistered conceptual replication study (Study 2) provided more evidence for the “smart but evil” stereotype. Further directions of research as well as implications for practice are discussed.
A Single Paradigm for Implicit and Statistical Learning
2019-07-01

Abstract Implicit learning generally refers to the acquisition of structures that, like knowledge of natural language grammar, are not available to awareness. In contrast, statistical learning has frequently been related to learning language structures that are explicitly available, such as vocabulary. In this paper, we report an experimental paradigm that enables testing of both classic implicit and statistical learning in language. The paradigm employs an artificial language comprising sentences that accompany visual scenes that they represent, thus combining artificial grammar learning with cross‐situational statistical learning of vocabulary. We show that this methodology enables a comparison between acquisition of grammar and vocabulary, and the influences on their learning. We show that both grammar and vocabulary are promoted by explicit information about the language structure, that awareness of structure affects acquisition during learning, and awareness precedes learning, but is not distinctive at the endpoint of learning. The two traditions of learning—implicit and statistical—can be conjoined in a single paradigm to explore both the phenomenological and learning consequences of statistical structural knowledge.
Molecular subtypes and response to immunotherapy in bladder cancer patients
2019-07-01

The introduction of immunotherapy for the treatment of patients with advanced urothelial carcinoma has led to a significant interest in markers predicting therapy response. As in other tumor entities, approximately 20% of patients show objective response to single drug checkpoint inhibition. The identification of these patients is of great interest in order to avoid ineffective and expensive treatment.
IRAS 23385+6053: an embedded massive cluster in the making
2019-07-01

\\nContext. This study is part of the CORE project, an IRAM/NOEMA large program consisting of observations of the millimeter continuum and molecular line emission towards 20 selected high-mass star-forming regions. The goal of the program is to search for circumstellar accretion disks, study the fragmentation process of molecular clumps, and investigate the chemical composition of the gas in these regions.\\nAims. We focus on IRAS 23385+6053, which is believed to be the least-evolved source of the CORE sample. This object is characterized by a compact molecular clump that is IR-dark shortward of 24 μm and is surrounded by a stellar cluster detected in the near-IR. Our aim is to study the structure and velocity field of the clump.\\nMethods. Observations were performed at ~1.4 mm and employed three configurations of NOEMA and additional single-dish maps, merged with the interferometric data to recover the extended emission. Our correlator setup covered a number of lines from well-known hot core tracers and a few outflow tracers. The angular (~0′′.45–0′′.9) and spectral (0.5 km s−1) resolutions were sufficient to resolve the clump in IRAS 23385+6053 and investigate the existence of large-scale motions due to rotation, infall, or expansion.\\nResults. We find that the clump splits into six distinct cores when observed at sub-arcsecond resolution. These are identified through their 1.4 mm continuum and molecular line emission. We produce maps of the velocity, line width, and rotational temperature from the methanol and methyl cyanide lines, which allow us to investigate the cores and reveal a velocity and temperature gradient in the most massive core. We also find evidence of a bipolar outflow, possibly powered by a low-mass star.\\nConclusions. We present the tentative detection of a circumstellar self-gravitating disk lying in the most massive core and powering a large-scale outflow previously known in the literature. In our scenario, the star powering the flow is responsible for most of the luminosity of IRAS 23385+6053 (~3000 L⊙). The other cores, albeit with masses below the corresponding virial masses, appear to be accreting material from their molecular surroundings and are possibly collapsing or on the verge of collapse. We conclude that we are observing a sample of star-forming cores that is bound to turn into a cluster of massive stars.\\n
Reproductive Success, Relationship Orientation, and Sexual Behavior in Heterosexuals: Relationship With Chronotype, Sleep, and Sex
2019-07-01

Following previous studies, chronotype was related to sexual attitudes and behavior. Evening people tend to be more promiscuous and follow short-term mating strategies and extra-pair matings (EPM), which might lead to a higher reproductive success. In this study, one aim was to assess reproductive success directly by asking for children, and, second, to obtain a higher sample size for the analysis of sexual behavior and chronotype than in previous studies. N = 1,843 heterosexual persons (551 men, 1,288 women, 4 without data) responded to our online survey. Five hundred fifty-nine persons were single and 1,281 in a relationship; 203 reported having children (1.9 ± 0.81). Age was positively related and age at first intercourse was negatively related to the number of children. People being later chronotypes had fewer children, and shorter sleep duration was linked with more children. Extroversion was correlated with number of children, as was the long-term relationship orientation. Sociosexual orientation and EPM were unrelated to number of children. Age at first intercourse was earlier in evening people, and unrestricted sociosexuality was higher in late chronotypes. Morning orientation correlated with long-term relationship orientation and eveningness with short-term relationship orientation. Number of sexual partners was lower in morning people. Men were more evening oriented, later chronotypes, and slept shorter. There were no differences in sociosexual behavior, but men were less restricted in attitude and desire. Men scored higher on short-term relationship orientation and women higher on long-term relationship orientation. This study confirmed previous results about chronotype and sexual behavior but provided the first evidence that morningness was related to higher reproductive success.
Abstract 1146: [18F]FPyGal: A novel ß-galactosidase specific PET tracer for in vivo imaging of tumor senescence
2019-07-01

Abstract Senescence influences treatment outcome in cancer. Therefore it is of great interest to develop a diagnostic tool to detect senescent cells in cancer patients. Here we describe the evaluation of the PET tracer FPyGal for non-invasive imaging of ß-galactosidase as a surrogate marker for senescence. In vitro, we induced senescence in HCT116 cells by doxorubicin, in a liver progenitor cell line by p53-reactivation and in two liver carcinoma cell lines by a ribosomal checkpoint inhibitor (RCI). The cells were then incubated with FPyGal and tracer uptake was determined in a gamma-counter. For in vivo testing, the described cell lines were injected s.c. in mice. The tumor bearing mice were then treated appropriately to induce senescence. PET/MR scans were performed after i.v. injection of FPyGal for assessment of tracer uptake in the tumors. Ex vivo autoradiographies and X-Gal stainings were prepared to correlate intratumoral distribution of ⇓-galactosidase activity and tracer uptake. After toxicology studies, a pilot first-in-man study was performed in a cancer patient treated with Alisertib. Compared to the respective control cells, in vitro tracer uptake was significantly increased in all four cellular models tested. The strongest increase was observed in one of the liver carcinoma cell lines with a &amp;gt;3-fold increase in senescent cells. FPyGal tracer uptake increased in control HCT116 tumors from 1.1 to 1.7%ID/cc in senescent cells in in vivo PET/MRI studies and in the HRas model from 0.9 to 1.5 %ID/cc. In one of the liver tumor models we could observe a 2-fold increase in treated mice. Ex vivo ⇓-galactosidase staining and IHC of tumor tissue confirmed induction of senescence. Autoradiography and X-Gal staining showed an intratumoral correlation of ⇓-gal activity and FPyGal uptake. The compound passed the toxicology tests. A first patient study revealed high and heterogeneous tracer uptake in a liver metastasis. FPyGal shows increased in vitro and in vivo uptake in senescent cells and tumors. No toxicity of the compound could be detected and a first-in-man study showed promising results. Clinical trials including histological cross-validation are currently being prepared. Citation Format: Marcel A. Krueger, Jonathan M. Cotton, Benyuan Zhou, Katharina Wolter, Johannes Schwenck, Anna Kuehn, Kerstin Fuchs, Andreas Maurer, Christian La Fougere, Lars Zender, Bernd J. Pichler. [18F]FPyGal: A novel ß-galactosidase specific PET tracer for in vivo imaging of tumor senescence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1146.
Editors’ Introduction: Aligning Implicit Learning and Statistical Learning: Two Approaches, One Phenomenon
2019-07-01

Abstract This editors’ introduction provides the background to the special issue. We first outline the rationale for bringing together, in a single volume, leading researchers from two distinct, yet related research strands, implicit learning and statistical learning. The aim of the special issue is to facilitate the development of a shared understanding of research questions and methodologies, to provide a platform for discussing similarities and differences between the two strands, and to encourage the formulation of joint research agendas. We then introduce the new contributions solicited for this special issue and provide our perspective on the agenda setting that results from combining these two approaches.
ShuffleNASNets: Efficient CNN models through modified Efficient Neural Architecture Search
2019-07-01

Neural network architectures found by sophistic search algorithms achieve\\nstrikingly good test performance, surpassing most human-crafted network models\\nby significant margins. Although computationally efficient, their design is\\noften very complex, impairing execution speed. Additionally, finding models\\noutside of the search space is not possible by design. While our space is still\\nlimited, we implement undiscoverable expert knowledge into the economic search\\nalgorithm Efficient Neural Architecture Search (ENAS), guided by the design\\nprinciples and architecture of ShuffleNet V2. While maintaining baseline-like\\n2.85% test error on CIFAR-10, our ShuffleNASNets are significantly less\\ncomplex, require fewer parameters, and are two times faster than the ENAS\\nbaseline in a classification task. These models also scale well to a low\\nparameter space, achieving less than 5% test error with little regularization\\nand only 236K parameters.\\n
Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
2019-07-01

Garcinol, an anti-inflammatory and anti-carcinogenic polyisoprenylated benzophenone isolated from Garcinia plants, stimulates tumor cell apoptosis and suicidal erythrocyte death, but supports the survival of hepatocytes and neurons. The present study explored whether the substance influences platelet function and/or apoptosis. To this end, we exposed murine blood platelets to garcinol (33 μM, 30 min) without and with activation by collagen-related peptide (CRP) (2–5 μg/mL) or thrombin (0.01 U/mL); flow cytometry was employed to estimate cytosolic Ca2+-activity ([Ca2+]i) from Fluo-3 fluorescence, platelet degranulation from P-selectin abundance, integrin activation from αIIbβ3 integrin abundance, caspase activity utilizing an Active Caspase-3 Staining kit, phosphatidylserine abundance from annexin-V-binding, relative platelet volume from forward scatter, and aggregation utilizing staining with CD9-APC and CD9-PE. As a result, in the absence of CRP and thrombin, the exposure of the platelets to garcinol did not significantly modify [Ca2+]i, P-selectin abundance, activated αIIbβ3 integrin, annexin-V-binding, cell volume, caspase activity, and aggregation. Exposure of platelets to CRP or thrombin was followed by a significant increase of [Ca2+]i, P-selectin abundance, αIIbβ3 integrin activity, annexin-V-binding, caspase activity, and aggregation, as well as significant cell shrinkage. All effects of CRP were strong and significant; those of thrombin were only partially and slightly blunted in the presence of garcinol. In conclusion, garcinol blunts CRP-induced platelet activity, apoptosis and aggregation.
Decade‐long X‐ray observations of HESS J0632+057
2019-07-01

Abstract We present the results of a decade of X‐ray observations of the gamma ray loud binary HESS J0632+057 and interpret the available broadband data in view of the system geometry and emission mechanisms. We have performed an analysis of all X‐ray data available to date from Swift , XMM‐Newton , Chandra , NuSTAR , and Suzaku . We refine the orbital period of the system to be days (95% c.l.), consistent with previous studies but measured with significantly better accuracy. We report on a hydrogen column density and spectral slope variation along the orbit. We argue that the observed variability can be explained within an “inclined disk” model in which the orbit of the compact object is inclined to the disk of the Be star. We show that the observed X‐ray to TeV emissions can originate from a broken cut‐off power‐law population of electrons and describe a way in which future X‐ray/TeV observations can distinguish between the proposed model and the alternative flip‐flop emission scenario of this system.
Automated Detection of Fetal Brain Signals with Principal Component Analysis
2019-07-01

Detection of fetal brain signals in fetal magnetoencephalographic recordings is - due to the low signal to noise ratio - challenging for researchers in this field. Up to now, state of the art is a manual evaluation of the signal. To make the evaluation more reproducible and less time consuming, an approach using Principal Component Analysis is introduced. Locations of the channels of most importance for the first three principal components are taken into account and their possibility of resembling brain activity evaluated. Data with auditory stimulation are taken for this analysis and trigger averaged signals from the channels selected as brain activity (manually & automatically) compared. Comparisons are done with regard to their average baseline activity, activity during a window of interest and timing and amplitude of their highest auditory event-related peak. The number of evaluable data sets showed to be lower for the automated compared to manual approach but auditory event-related peaks did not differ significantly in amplitude or timing and in both cases there was a significant activity change following the tone event. The given results and the advantage of reproducibility make this method a valid alternative.
Abstract 1146: [18F]FPyGal: A novel ß-galactosidase specific PET tracer forin vivoimaging of tumor senescence
2019-07-01

Senescence influences treatment outcome in cancer. Therefore it is of great interest to develop a diagnostic tool to detect senescent cells in cancer patients. Here we describe the evaluation of the PET tracer FPyGal for non-invasive imaging of ß-galactosidase as a surrogate marker for senescence. In vitro, we induced senescence in HCT116 cells by doxorubicin, in a liver progenitor cell line by p53-reactivation and in two liver carcinoma cell lines by a ribosomal checkpoint inhibitor (RCI). The cells were then incubated with FPyGal and tracer uptake was determined in a gamma-counter. For in vivo testing, the described cell lines were injected s.c. in mice. The tumor bearing mice were then treated appropriately to induce senescence. PET/MR scans were performed after i.v. injection of FPyGal for assessment of tracer uptake in the tumors. Ex vivo autoradiographies and X-Gal stainings were prepared to correlate intratumoral distribution of ⇓-galactosidase activity and tracer uptake. After toxicology studies, a pilot first-in-man study was performed in a cancer patient treated with Alisertib. Compared to the respective control cells, in vitro tracer uptake was significantly increased in all four cellular models tested. The strongest increase was observed in one of the liver carcinoma cell lines with a >3-fold increase in senescent cells. FPyGal tracer uptake increased in control HCT116 tumors from 1.1 to 1.7%ID/cc in senescent cells in in vivo PET/MRI studies and in the HRas model from 0.9 to 1.5 %ID/cc. In one of the liver tumor models we could observe a 2-fold increase in treated mice. Ex vivo ⇓-galactosidase staining and IHC of tumor tissue confirmed induction of senescence. Autoradiography and X-Gal staining showed an intratumoral correlation of ⇓-gal activity and FPyGal uptake. The compound passed the toxicology tests. A first patient study revealed high and heterogeneous tracer uptake in a liver metastasis. FPyGal shows increased in vitro and in vivo uptake in senescent cells and tumors. No toxicity of the compound could be detected and a first-in-man study showed promising results. Clinical trials including histological cross-validation are currently being prepared.Citation Format: Marcel A. Krueger, Jonathan M. Cotton, Benyuan Zhou, Katharina Wolter, Johannes Schwenck, Anna Kuehn, Kerstin Fuchs, Andreas Maurer, Christian La Fougere, Lars Zender, Bernd J. Pichler. [18F]FPyGal: A novel ß-galactosidase specific PET tracer for in vivo imaging of tumor senescence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1146.