julilili42/papers huggingface dataset:
The Dynamic and Theatrical Worlds of the ‘Midan’
2016-01-01

‘All the world’s a stage ...’ tells us the Bard of Avon. Goffman’s application of Shakespeare’s age-old metaphor to our everyday practices helps us understand the complexity of social interaction. His dramaturgical sociology allows us to engage better with the frames of repeated behaviors that we ‘perform’ in social contexts. However, emphasizing the theatricality of action and interaction, especially for problems at the macro-level like acts of revolution, is crucial to make sense of the form of spectacle that results in popular demonstrations, sit-ins etc., in which everyone contributes as actors/spectators to imagine and/or negotiate a different way of being or governance. This paper aims to study the active dynamics of turning an everyday locale such as Midan al-Tahrir into a liminal space in which staged performances on political and artistic levels take place in an attempt to shed light on the inseparability of the political and the aesthetic, the event and the performance. The Egyptian revolution of 2011 highlights the public’s awareness of the symbolic and performative importance of occupying a space, and the creative power that both nurtures and feeds on this liminal experience. In this very example, the Arabic word midan is helpful because of its dynamic connotations as opposed to the static English ‘square’, as this paper examines the experience of Tahrir as a ‘Midan’ where the real, the ritualistic and the playful actively coexist.
Methyl Iodide Exposure Presenting as Severe Chemical Burn Injury with Neurological Complications and Prolonged Respiratory Insufficiency
2016-01-01

Methyl iodide (iodomethane) is a monohalomethane that is mainly used as an intermediate in the manufacturing of different pharmaceuticals and pesticides. Until now, only 13 cases of methyl iodide poisoning have been described in the literature. The authors present the first case of severe chemical burn injury due to methyl iodide exposure in a 36-year-old Caucasian man who suffered superficial to partial-thickness burn injuries over 75% of his BSA and developed neurological malfunctions and prolonged respiratory insufficiency. Human poisoning with methyl iodide is very rare. In addition to the already described neurological symptoms and respiratory insufficiency, severe chemical burn injury can cause a life-threatening medical emergency.
A Methodology for Deriving Conceptual Data Models from Systems Engineering Artefacts
2016-01-01

This paper presents a novel methodology for deriving Conceptual Data Models in the scope of Model-based Systems Engineering. Based on an assessment of currently employed methodologies, substantial limitations of the state of the art are identified. Consequently, a new methodology, overcoming present shortcomings, is elaborated, containing detailed and prescriptive guidelines for deriving conceptual data models used for representing engineering data in a multi-disciplinary design process. For highlighting the applicability and benefits of the approach, the derivation of a semantically strong conceptual data model in the context of Model-based Space Systems Engineering is presented as a case study.
Abstract B057: Optimizing the high throughput in vitro priming of tumor specific T cells
2016-01-01

Abstract Peptide-based vaccines are a promising strategy for immunotherapy against cancer. Our group has characterized large numbers of HLA ligands from tumor cells; among them many that might be used for in vivo induction of tumor-specific immune responses. For the development of peptide-based immunotherapies such peptides should be able to induce in vivo tumor-directed immune responses, especially by CD8+ T cells that have a key role in inducing death of tumor cells. The aim of our work is to establish a fast and efficient workflow for immunogenicity testing of tumor-extracted HLA ligands. T cells usually depend on professional antigen presenting cells such as autologous dendritic cells (DCs) for specific induction and expansion. Since the generation of dendritic cells is expensive and time consuming with varying quality and amount of differentiated DCs, we established an artificial system to replace cell-based in vitro priming of T cells, streptavidin-coated artificial antigen presenting cells loaded with defined amounts of recombinant HLA molecules and costimulatory antibodies such as anti-CD28. Using the standard protocol, CD8+ T cells are stimulated three times with artificial antigen presenting cells in weekly intervals in the presence of IL-2 and IL-12. Peptide-specific CD8+ T cells are identified by tetramer staining. Our group started to vary different parameters of this protocol to increase the frequency and number of antigen specific T cells. Alternate costimulatory antibodies and cytokines proved successful to reach that goal. Employing artificial APCs for in vitro priming of tumor-reactive T cells will foster immunogenicity analysis of novel peptides for immunotherapy. Citation Format: Lea Prokop, Stefanie Souczek, Janet Peper, Hans-Georg Rammensee, Stefan Stevanović. Optimizing the high throughput in vitro priming of tumor specific T cells. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B057.
Abstract B104: Characterization and specificity analysis of tumor infiltrating lymphocytes in ovarian carcinoma
2016-01-01

Abstract Introduction: The great majority of patients suffering from ovarian cancer (OvCa) relapse after initial therapy, making OvCa the most lethal gynecological malignancy. The immunogenic nature of OvCa is highlighted by frequent infiltration with immune cells, which represent an independent prognostic factor in OvCa patients and argues in favor for the development of immunotherapies, including peptide-based cancer vaccines. The phenotype of OvCa infiltrating T cells as well as their specificity and expression of inhibitory receptors is so far unknown. This information is however critically important for the design of novel immunotherapies including the application of checkpoint inhibitor therapy. Materials and Methods: Tumor infiltrating lymphocytes (TILs) were isolated from fresh tumor tissue of OvCa patients obtained during tumor debulking surgery. The phenotype and expression of inhibitory molecules LAG3, CTLA4, PD1 and TIM3 was assessed by flow cytometry. Peptide specificity of infiltrating T cells was analyzed by screening for reactivity against naturally presented HLA ligands employing IFNγ ELISPOT and flow cytometry. These natural presented HLA ligands have been originally identified by mass spectrometry in an extensive HLA ligandome analysis of OvCa samples. Results: TILs from each analyzed OvCa sample demonstrated expression of at least one of the investigated inhibitory receptors. While LAG3 and PD1 were most prominent during this analysis, CTLA4 expression was only weak or absent. Furthermore, high amounts of effector memory, but few naive or central memory T cells were present. Notably, OvCa infiltrating CD4+ T cells and CD8+ T cells shared a similar expression pattern of inhibitory surface markers within each single patient. We further obtained first results in peptide-specificity of OvCa-derived T cells by screening them for reactivity against naturally presented HLA ligands identified on OvCa samples. Conclusion: In summary, we provide first insight into the expression of various inhibitory receptors on OvCa infiltrating T cells and their peptide specificities. Citation Format: Janet Kerstin Peper, Kevin Röhle, Heiko Schuster, Philipp Wagner, Hans-Georg Rammensee, Stefan Stevanovic. Characterization and specificity analysis of tumor infiltrating lymphocytes in ovarian carcinoma. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B104.
Abstract A115: Cancer vaccine development for hepatocellular carcinoma – HEPAVAC
2016-01-01

Abstract The HEPAVAC Consortium aims to develop a highly innovative, novel cancer vaccine approach for hepatocellular carcinoma (HCC). The international project consortium consists of 9 European Partners from academia and the biotech industry with complementary and substantial expertise in developing immunotherapeutic strategies to treat cancer. The project has started in September 2013 and is supported by the European Commission's 7th Framework Program (www.hepavac.eu). HCC/normal adjacent tissue matched samples have been collected for HLA immunopeptidome analysis. 17 HCC samples from HLA-A*02+ patients and 15 samples from HLA-A*24+ patients have been analysed by mass spectrometry (LC-MS/MS). RNA-expression profiles have been established for 12 HCC samples. HLA-presentation/expression of peptides and mRNA on primary HCC samples are compared to n&amp;gt;140 normal tissue samples from relevant organs (including heart, brain, lung, kidney, liver, nerve, skin etc.) from Immatics' database. A total of 9051 HLA-A*02-restricted different tumor-associated peptides (TUMAPs) have been identified from HLA-A*02+ samples, while a total of 3286 different HLA-A*24-restricted TUMAPs have been identified from HLA-A*24+ samples. Of these, 33 HLA-A*02+ TUMAPS and 33 HLA-A*24+ TUMAPs are currently in the process of validation, including peptide synthesis, immunogenicity testing and pharmaceutical evaluation. Most promising TUMAP candidates show selective expression only in HCC samples and no expression in normal tissues. In parallel, more than 6600 HLA-DR TUMAPs have been identified in Hep3B cells transfected with CIITA as well as an average of 1500 HLA-DR TUMAPs have been identified in HCC samples. Additional HLA-DR TUMAPs derived by distinct CIITA-transfected cell lines with different HLA-DR haplotypes are under scrutiny. The discovery phase of the HEPAVAC project is proceeding according to the proposed timelines. HCC-specific epitopes to be included in the vaccine cocktail will be selected in the coming weeks for GMP production. In parallel, preclinical studies assessing the formulation and combination of the immunological RNA-based adjuvant (RNAdjuvant®) with peptide cocktails are underway. Citation Format: Luigi Buonaguro, Sarah Kutscher, Roberto Accolla, Yuk T. Ma, Regina Heidenreich, Francesco Izzo, Alfred Koenigsrainer, Markus Loeffler, Phillip Mueller, Andrea Mayer, Hans-Georg Rammensee, Bruno Sangro, Sven Francque, Danila Valmori, Toni Weinschenk, Harpreet Singh-Jasuja. Cancer vaccine development for hepatocellular carcinoma – HEPAVAC. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr A115.
Morphometric Optic Nerve Head Analysis in Glaucoma Patients: A Comparison between the Simultaneous Nonmydriatic Stereoscopic Fundus Camera (Kowa Nonmyd WX3D) and the Heidelberg Scanning Laser Ophthalmoscope (HRT III)
2016-01-01

Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucoma were analyzed regarding their vertical cup-to-disc-ratio (CDR). Vertical CDR, disc area, cup volume, rim volume, and maximum cup depth were assessed with both devices by one examiner. Mean bias and limits of agreement (95% CI) were obtained using scatter plots and Bland-Altman analysis. Results. Overall vertical CDR comparison between HRT III and Kowa nonmyd WX3D measurements showed a mean difference (limits of agreement) of −0.06 (−0.36 to 0.24). For the CDR &lt; 0.5 group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">24</mml:mn></mml:math>) mean difference in vertical CDR was −0.14 (−0.34 to 0.06) and for the CDR ≥ 0.5 group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">16</mml:mn></mml:math>) 0.06 (−0.21 to 0.34). Conclusion. This study showed a good agreement between Kowa nonmyd WX3D and HRT III with regard to widely used optic nerve head parameters in patients with glaucomatous optic neuropathy. However, data from Kowa nonmyd WX3D exhibited the tendency to measure larger CDR values than HRT III in the group with CDR &lt; 0.5 group and lower CDR values in the group with CDR ≥ 0.5.
Title to be determined
2016-01-01

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Lensch, "Title to be determined," in Imaging and Applied Optics 2016, (Optica Publishing Group, 2016), paper ITh3D.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Harmony Society in Württemberg, Pennsylvania and Indiana
2016-01-01

Ehmer provides a new European and American history of the Harmony Society, the radical German Pietist association led by George Rapp, which relocated from Württemberg to western Pennsylvania and Indiana in the early nineteenth century. Ehmer places Harmonist theology within the context of Württemberg Pietism, showing how Rapp developed his own distinctive interpretation of an apocalyptic timetable familiar to Pietists. Ehmer argues that the Harmony Society's trans-Atlantic emigration and adoption of communal property may only be understood in light of their millennial beliefs, though communal practices at Harmony, New Harmony and Economy, also represented the transporting of some inherited forms of communal behaviour from the German village to the American frontier.
Interlude III: On Interpretation
2016-01-01

The essays in Part III of this volume indicate to what extent critical theory draws on resources from beyond the realm of literary and cultural theory in the narrower sense, such as ecological thinking (Zapf), ethics (Attridge, Domsch, and Middeke), or complexity science (Walsh). While doing so, all contributions insisted on the particular cultural productivity of literature, which in turn inspires theoretical reflections. All contributions in Part III thus provide good examples for the 'dispositional, as well as institutional, anchorage' (Brubaker 216) of literary and cultural theory highlighted at the end of Interlude II. The medium for this particular cultural productivity of literature is, of course, the text, just as it is, albeit with different rules, the medium for the particular cultural productivity of literary and cultural theory itself. If there is a unique selling point for the expertise accumulated in the disciplines of literary and cultural studies, it should be just this: that there is a long and very sophisticated tradition of reflection on the role of texts in modern culture in terms of the features that can be described under the rubrics of philological comparison, rhetoric, form, or structure, in terms of the shapes and functions that texts can assume in different media environments (writing, print, electronic media), and in terms of the reading protocols that may be desirable (hermeneutics, hermeneutics of suspicion, deconstruction, analysis, ...). The essays in Part IV illuminate various aspects of this centrality. After introductory reflections on 'The Fate of Texts under Changing Theory' (Grabes), the remaining contributions address the potential residing in the isomorphism of literature and theory (Alworth), the role of the mediality and materiality of texts for reading processes (Reinfandt), and the long-standing relation between form and textuality (Chaudhuri).
Confessional Belonging and National Identity: A Case Study of Serbia, Croatia, and Germany
2016-01-01

It is difficult to comprehend that at the dawn of the twenty-first century wars are still being fought over religious, or confessional, identity and yet, despite economical, technological, and cultural progress, as well as the advancements achieved through ecumenical and interreligious dialogue, the trouble generated by religious conflicts has actually increased and is still a significant concern.1 In this chapter, I wish to examine the relationship between the confessional and national identity by analyzing the conditions surrounding one particular conflict: the war fought in Croatia from 1991 until 1995. Since the aim of this chapter is to present a theological perspective on elements of this particular war, no general explanation of other religiously fueled, violent conflicts in the world can be offered.
Introduction: The Place of Theory Today
2016-01-01

Taking stock of the 'history and current condition of theory' for teaching purposes in 2011, Richard Bradford diagnosed 'the ongoing, curious—though apparently not atrophied—condition of After Theory' for the disciplines of literary and cultural studies (Bradford 1–2). While there is certainly a lot of theoretical thinking being done, there seems to be no unifying paradigm which could serve as a platform for dialogue between the various theoretical interests that can be identified, such as, for example, the renewed interest in the phenomenological side of reading processes that figures the (reading of a) text as an event (see Attridge; Felski 2008; Wiemann), the increased acknowledgement of the foundational importance of media history for all cultural (and that includes theoretical) practices and formations (see, for example, Siskin and Warner), the impact of cognitive approaches on a variety of fields in the humanities (see Zunshine), the turn towards notions of a cultural ecology in the larger context of complexity thinking (chaos theory, systems theory, self-organization, posthumanism; see, for example, Morton; Wolfe), or the longing for 'new sociologies of literature' (Felski and English) and other hotspots of theoretical debate identified by the journal New Literary History under Rita Felski's editorship.
Kant’s Philosophy of Projection: The Camera Obscura of the Inaugural Dissertation
2016-01-01

In his 1770 Inaugural Dissertation, Kant explores the mechanisms of projection involved in logical judgments. He discovers three types: (1) the projection of the subjective onto the objective, (2) the projection of the intelligible onto the sensitive, and (3) the projection of predicates onto a grammatical subject. In 1781, in the Critique of Pure Reason, he points out three possible errors in logical judgments: (1) the projection from the subject onto the object (Amphiboly), (2) the projection back from the subject onto the subject (Paralogism), and (3) the projection from the predicate onto the subject or the object (Antinomy). Kant thereby anticipates a critique of German Idealism and contemporary metaphysics—which are all conceivable as variants of projections in logical judgments.
Collective nonlinear effects in metal oligomers using matched cylindrical vector beams
2016-01-01

We prepare metal oligomers whose structure is matched to the local polarization of focused cylindrical vector beams. Significant collective second-harmonic signals prove the potential of such beams in engineering nonlinear effects on the nanoscale.
Crizotinib Induced Rapid Remissions of Lung Adenocarcinoma
2016-01-01

We present an imaging case of rapid pulmonary remission in a 50year-old smoking woman.Our patient was a strong smoker (30 pack years), she has a pulmonary adenocarcinoma in right middle lobe with multiple pulmonary metastases.
Limited Time from the Diabetes Patients' Perspective: Need for Conversation with the Eye Specialist
2016-01-01

&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; Facing the lack of time, busy retina consultants should be aware of how the patients would prefer that time is spent and whether they wish the specialist to talk more at the expense of other medical activities. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; 810 persons with diabetes were asked to divide the time of 10 min between examination, consultation and treatment when envisioning a real-life scenario of diabetic retinopathy (NCT02311504). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; With the increasing duration of diabetes, patients wanted significantly more time for diagnostics (p = 0.028), while age was found to be associated with less time for treatment (p = 0.009). Female subjects tended to prefer only little more time for talking (p = 0.051) in comparison with males, who slightly favored therapy (p = 0.025). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The large majority recognized the need for diagnostics in their allocation of time. If individual patients are confronted with the health care perspective of time constraints, this might improve the understanding of prioritization.
The interference effects of multi-channel pion-pion scattering contributions to the final states of Ψ- and γ-meson family decays
2016-01-01

It is shown that the basic shape of dipion mass distributions in the two-pion\\ntransitions of both charmonia and bottomonia states are explained by an unified\\nmechanism based on the contribution of the , and\\n coupled channels including their interference.\\n
Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels
2016-01-01

Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions.Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol(1-100 ?M),BaCl2 (1 mM),a antagonist of inwardly rectifying pota?ssium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.