julilili42/papers huggingface dataset:
Biocultural evidence of precise manual activities in an Early Holocene individual of the high‐altitude Peruvian Andes
2020-11-16

Abstract Objectives Cuncaicha, a rockshelter site in the southern Peruvian Andes, has yielded archaeological evidence for human occupation at high elevation (4,480 masl) during the Terminal Pleistocene (12,500–11,200 cal BP), Early Holocene (9,500–9,000 cal BP), and later periods. One of the excavated human burials (Feature 15‐06), corresponding to a middle‐aged female dated to ~8,500 cal BP, exhibits skeletal osteoarthritic lesions previously proposed to reflect habitual loading and specialized crafting labor. Three small tools found in association with this burial are hypothesized to be associated with precise manual dexterity. Materials and methods Here, we tested this functional hypothesis through the application of a novel multivariate methodology for the three‐dimensional analysis of muscle attachment surfaces (entheses). This original approach has been recently validated on both lifelong‐documented anthropological samples as well as experimental studies in nonhuman laboratory samples. Additionally, we analyzed the three‐dimensional entheseal shape and resulting moment arms for muscle opponens pollicis . Results Results show that Cuncaicha individual 15‐06 shows a distinctive entheseal pattern associated with habitual precision grasping via thumb‐index finger coordination, which is shared exclusively with documented long‐term precision workers from recent historical collections. The separate geometric morphometric analysis revealed that the individual's opponens pollicis enthesis presents a highly projecting morphology, which was found to strongly correlate with long joint moment arms (a fundamental component of force‐producing capacity), closely resembling the form of Paleolithic hunter‐gatherers from diverse geo‐chronological contexts of Eurasia and North Africa. Discussion Overall, our findings provide the first biocultural evidence to confirm that the lifestyle of some of the earliest Andean inhabitants relied on habitual and forceful precision grasping tasks.
Starvation-Dependent Inhibition of the Hydrocarbon Degrader Marinobacter sp. TT1 by a Chemical Dispersant
2020-11-16

During marine oil spills, chemical dispersants are used routinely to disperse surface slicks, transferring the hydrocarbon constituents of oil into the aqueous phase. Nonetheless, a comprehensive understanding of how dispersants affect natural populations of hydrocarbon-degrading bacteria, particularly under environmentally relevant conditions, is lacking. We investigated the impacts of the dispersant Corexit EC9500A on the marine hydrocarbon degrader Marinobacter sp. TT1 when pre-adapted to either low n-hexadecane concentrations (starved culture) or high n-hexadecane concentrations (well-fed culture). The growth of previously starved cells was inhibited when exposed to the dispersant, as evidenced by 55% lower cell numbers and 30% lower n-hexadecane biodegradation efficiency compared to cells grown on n-hexadecane alone. Cultures that were well-fed did not exhibit dispersant-induced inhibition of growth or n-hexadecane degradation. In addition, fluorescence microscopy revealed amorphous cell aggregate structures when the starved culture was exposed to dispersants, suggesting that Corexit affected the biofilm formation behavior of starved cells. Our findings indicate that (previous) substrate limitation, resembling oligotrophic open ocean conditions, can impact the response and hydrocarbon-degrading activities of oil-degrading organisms when exposed to Corexit, and highlight the need for further work to better understand the implications of environmental stressors on oil biodegradation and microbial community dynamics.
Increased Expressions of Matrix Metalloproteinases (MMPs) in Prostate Cancer Tissues of Men with Type 2 Diabetes
2020-11-16

Type 2 diabetes (T2D) is associated with worse prognosis of prostate cancer (PCa). The molecular mechanisms behind this association are still not fully understood. The aim of this study was to identify key factors, which contribute to the more aggressive PCa phenotype in patients with concurrent T2D. Therefore, we investigated benign and PCa tissue of PCa patients with and without diabetes using real time qPCR. Compared to patients without diabetes, patients with T2D showed a decreased E-cadherin/N-cadherin (CDH1/CDH2) ratio in prostate tissue, indicating a switch of epithelial-mesenchymal transition (EMT), which is a pivotal process in carcinogenesis. In addition, the gene expression levels of matrix metalloproteinases (MMPs) and CC chemokine ligands (CCLs) were higher in prostate samples of T2D patients. Next, prostate adenocarcinoma PC3 cells were treated with increasing glucose concentrations to replicate hyperglycemia in vitro. In these cells, high glucose induced expressions of MMPs and CCLs, which showed significant positive associations with the proliferation marker proliferating cell nuclear antigen (PCNA). These results indicate that in prostate tissue of men with T2D, hyperglycemia may induce EMT, increase MMP and CCL gene expressions, which in turn activate invasion and inflammatory processes accelerating the progression of PCa.
Comparison of Two Ensemble-Kalman Filter Based Methods for Estimating Aquifer Parameters from Real 3-D Hydraulic and Tracer Tomographic Tests
2020-11-16

Pumping and tracer tests are site-investigation techniques frequently used to determine hydraulic conductivity. Tomographic test layouts, in which multiple tests with different combinations of injection and observation wells are performed, gain a better insight into spatial variability. While hydraulic tomography has repeatedly been applied in the field, tracer tomography lags behind. In a previous publication, we presented a synthetic study to investigate whether the ensemble Kalman Filter (EnKF) or the Kalman Ensemble Generator (KEG) performs better in inverting hydraulic- and tracer-tomographic data. In this work, we develop an experimental method for solute-tracer tomography using fluorescein as a conservative tracer. We performed hydraulic- and tracer-tomographic tests at the Lauswiesen site in Germany. We analyzed transient drawdown and concentration data with the EnKF and steady-state hydraulic heads and mean tracer arrival times with the KEG, obtaining more stable results with the KEG at lower computational costs. The spatial distribution of the estimated hydraulic conductivity field agreed with earlier descriptions of the aquifer at the site. This study narrows the gap between numerical studies and field applications for aquifer characterization at high resolution, showing the potential of combining ensemble-Kalman filter based methods with data collected from hydraulic and solute-tracer tomographic experiments.
INTEGRAL discovery of a high-energy tail in the microquasar Cygnus X-3
2020-11-16

Context. The X-ray spectra of X-ray binaries are dominated by emission of either soft or hard X-rays which defines their soft and hard spectral states. While the generic picture is relatively well understood, little is known about the interplay of the various media at work, or about the reasons why some sources do not follow common behavior. Cygnus X-3 is amongst the list of X-ray binaries that show quite complex behavior, with various distinct spectral states not seen in other sources. These states have been characterized in many studies. Because of its softness and intrinsic low flux above typically 50 keV, very little is known about the hard X/soft gamma-ray (100–1000 keV) emission in Cygnus X-3. Aims. Using the whole INTEGRAL data base, we aim to explore the 3–1000 keV spectra of Cygnus X-3. This allows to probe this region with the highest sensitivity ever, and search for the potential signature of a high-energy non-thermal component as sometimes seen in other sources. Methods. Our work is based on state classification carried out in previous studies with data from the Rossi X-Ray Timing Explorer. We extend this classification to the whole INTEGRAL data set in order to perform a long-term state-resolved spectral analysis. Six stacked spectra were obtained using 16 years of data from JEM-X (3–25 keV), ISGRI (25–300 keV), and SPI (20–400 keV). Results. We extract stacked images in three different energy bands, and detect the source up to 200 keV. In the hardest states, our purely phenomenological approach clearly reveals the presence of an additonnal component &gt; 50 keV in addition to the component usually interpreted as thermal Comptonization. We apply a more physical model of hybrid thermal/nonthermal corona ( EQPAIR ) to characterize this nonthermal component and compare our results with those of previous studies and analyses. Our modeling indicates a more efficient acceleration of electrons in states where major ejections are observed. We also evaluate and find a dependence of the photon index of the power law as a function of the strong orbital modulation of the source in the Flaring InterMediate state. This dependence could be due to a higher absorption when Cygnus X-3 is behind its companion. However, the uncertainties on the density column prevent us from drawing any firm conclusions.
Menatanthus mosbruggeri gen. nov. et sp. nov. – A flower with in situ pollen tetrads from the Paleocene maar lake of Menat (Puy-de-Dôme, France)
2020-11-16

Abstract The Paleocene Fossil-Lagerstätte Menat in France is well known for its wealth of outstandingly well preserved fossil insects and plants. Despite being known for more than a century, the palaeoflora, which is regarded as typical for the late Thanetian by some authors, has largely been neglected since the 1940s. New excavations and surveys yielded exceptionally well-preserved plant material, including a minute, heptamerous flower bearing in situ pollen tetrads, comparable to tetrads of the modern ericacean genus Kalmia L, in its anthers. The only known modern ericacean genus which is characterised by heptamerous flowers is Bejaria Mutis ex L., a basal relative of the tribe Phyllodoceae within Ericaceae, which also includes the genus Kalmia in a relatively basal position. However, heptamerous flowers also occur very rarely (mostly interpreted as teratologies) in a number of other modern Ericaceae, but also in various other modern angiosperm families. Due to the unique combination of a heptamerous flower with Kalmia -type pollen tetrads within the anthers, the new taxon Menatanthus mosbruggeri gen. nov. et sp. nov. is erected. The lack of morphological data from the flower itself and the fact that comparable pollen tetrads can be produced by a number of modern families, however, prevent an assignment of the new taxon to any known angiosperm family.
A Stochastic Framework to Optimize Monitoring Strategies for Delineating Groundwater Divides
2020-11-16

Surface-water divides can be delineated by analyzing digital elevation models. They might, however, significantly differ from groundwater divides because the groundwater surface does not necessarily follow the surface topography. Thus, in order to delineate a groundwater divide, hydraulic-head measurements are needed. Because installing piezometers is cost- and labor-intensive, it is vital to optimize their placement. In this work, we introduce an optimal design analysis that can identify the best spatial configuration of piezometers. The method is based on formal minimization of the expected posterior uncertainty in localizing the groundwater divide. It is based on the preposterior data impact assessor, a Bayesian framework that uses a random sample of models (here: steady-state groundwater flow models) in a fully non-linear analysis. For each realization, we compute virtual hydraulic-head measurements at all potential well installation points and delineate the groundwater divide by particle tracking. Then, for each set of virtual measurements and their possible measurement values, we assess the uncertainty of the groundwater-divide location after Bayesian updating, and finally marginalize over all possible measurement values. We test the method mimicking an aquifer in South-West Germany. Previous works in this aquifer indicated a groundwater divide that substantially differs from the surface-water divide. Our analysis shows that the uncertainty in the localization of the groundwater divide can be reduced with each additional monitoring well. In our case study, the optimal configuration of three monitoring points involves the first well being close to the topographic surface water divide, the second one on the hillslope toward the valley, and the third one in between.
Identification of Postoperative Foveal Displacement after Macular Surgery for Idiopathic Epiretinal Membrane
2020-11-16

<b>Introduction</b>: To analyze foveal displacement after macular surgery for idiopathic epiretinal membrane (iERM). <b>Methods</b>: Twenty-eight patients who underwent macular surgery for symptomatic iERM in one eye by one physician were included in this retrospective study. Spectral domain optical coherence tomography (SD-OCT) volume scans were acquired with a Spectralis OCT device (Heidelberg Spectralis). Using the follow-up view mode, the displacement of the fovea was classified and measured according to its postoperative location in the horizontal and/or vertical plane. <b>Results</b>: One day after surgery, 86% of eyes (24/28) showed foveal displacement. Vertical displacement occurred in a superior direction in 50% eyes, and in an inferior direction in 36% of the eyes. The postoperative mean foveal displacement on the vertical plane was 99 ± 82 μm (range, 0-300). Horizontal displacement occurred in a nasal direction in 21%, and temporally in 21%. The postoperative mean foveal displacement on the horizontal plane was 35 ± 45 μm (range, 0-123). One year after the macular surgery 69% of the eyes showed still a foveal dislocation. <b>Discussion</b>: Most of the eyes with iERM showed a foveal dislocation after the macular surgery. Our findings emphasize the necessity to carefully study of the OCT images in such eyes after the surgery as the manually determined postoperative foveal position may be in a different vertical or horizontal plane than the machine-generated pre- and postoperative overlay for the foveal position. Our findings may thus be helpful for surgeons to avoid misinterpretation when evaluating OCT images pre- and postoperatively.
Perceived Impact of Covid-19 Across Different Mental Disorders: A Study on Disorder-Specific Symptoms, Psychosocial Stress and Behavior
2020-11-17

The recent outbreak of the coronavirus disease (Covid-19) has plunged countries across the world into crisis. Both in the general population and in specific subgroups such as infected people or health care workers, studies have reported increased symptoms of anxiety, depression and stress. However, the reactions of individuals with mental disorders to Covid-19 have largely been neglected. The present study therefore aimed to investigate the perceived impact of Covid-19 and its psychological consequences on people with mental disorders. In this online survey, participants were asked to evaluate their disorder-specific symptoms, perceived psychosocial stress and behaviors related to Covid-19 in the current situation and retrospectively before the spread of Covid-19. The study included participants with self-identified generalized anxiety disorder (GAD), panic disorder and agoraphobia (PA), illness anxiety disorder (IA), social anxiety disorder (SAD), depression (DP), obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), eating disorders (ED), schizophrenia spectrum and other psychotic disorders (SP), other non-specified mental disorder (other) as well as mentally healthy controls (HC). The results of bayesian parameter estimation suggest that the symptom severity of DP, GAD, IA and BDD has deteriorated as a reaction to Covid-19. Across all mental disorders and HC, self-reported psychosocial stress levels were higher during the outbreak of Covid-19 compared to before. A reduced frequency of social contacts and grocery shopping was found for all participants. People with self-identified mental disorders showed higher personal worries about Covid-19 and a higher fear of contagion with Covid-19 than did HC. According to our findings, Covid-19 may reinforce symptom severity and psychosocial stress in individuals with mental disorders. In times of pandemics, special support is needed to assist people with mental disorders and to prevent symptom deterioration.
Changes in sleep schedule and chronotype due to COVID-19 restrictions and home office
2020-11-17

Abstract Background and objective In this study, we researched the effects of the COVID-19 restriction measures on the sleep health of N = 681 German residents (mean age: 28.63 years, SD: 10.49 years). Methods The data were collected with an anonymous online survey composed of validated questionnaires and additional questions to quantify changed circumstances during the pandemic. Data were collected from May 18 to June 17, 2020, while governmental restrictions were imposed in Germany. We exclusively analysed participants working in home office during this time. Results Participants woke up about 1 hour later during the COVID-19 restriction phase, while going to bed at almost the same time as before. During the week, participants slept about an hour longer, while sleep at weekends did not differ significantly. Social jetlag decreased from 1:39 ± 1:00 to 0:49 ± 0:42 min in our sample. The number of children in the household was a significant factor predicting sleep timing. Participants with children living in the same household slept longer and sleep onset was later. Conclusion In terms of sleep behaviour and, consequently, sleep health, participants benefited from the transition to home office. They were able to adapt their waking and working hours better to their biological rhythm, which reduced social jetlag.
Psychosis‐Like Behavior and Hyperdopaminergic Dysregulation in Human α‐Synuclein BAC Transgenic Rats
2020-11-17

Abstract Background Parkinson's disease psychosis is a prevalent yet underreported and understudied nonmotor manifestation of Parkinson's disease and, arguably, the most debilitating. It is unknown if α‐synuclein plays a role in psychosis, and if so, this endophenotype may be crucial for elucidating the neurodegenerative process. Objectives We sought to dissect the underlying neurobiology of novelty‐induced hyperactivity, reminiscent of psychosis‐like behavior, in human α‐synuclein BAC rats. Results Herein, we demonstrate a prodromal psychosis‐like phenotype, including late‐onset sensorimotor gating disruption, striatal hyperdopaminergic signaling, and persistent novelty‐induced hyperactivity (up to 18 months), albeit reduced baseline locomotor activity, that is augmented by d‐amphetamine and reversed by classical and atypical antipsychotics. MicroRNA‐mediated α‐synuclein downregulation in the ventral midbrain rescues the hyperactive phenotype and restores striatal dopamine levels. This phenotype is accompanied by an abundance of age‐, brain region– and gene dose–dependent aberrant α‐synuclein, including hyperphosphorylation, C‐terminal truncation, aggregation pathology, and mild nigral neurodegeneration (27%). Conclusions Our findings demonstrate a potential role of α‐synuclein in Parkinson's disease psychosis and provide evidence of region‐specific perturbations prior to neurodegeneration phenoconversion. The reported phenotype coincides with the latest clinical findings that suggest a premotor hyperdopaminergic state may occur, while at the same time, premotor psychotic symptoms are increasingly being recognized. © 2020 International Parkinson and Movement Disorder Society
Trout and Human Plasma Protein Binding of Selected Pharmaceuticals Informs the Fish Plasma Model
2020-11-17

Abstract Concerns are increasing that pharmaceuticals released into the environment pose a risk to nontarget organism such as fish. The fish plasma model is a read-across approach that uses human therapeutic blood plasma concentrations for estimating likely effects in fish. However, the fish plasma model neglects differences in plasma protein binding between fish and humans. Because binding data for fish plasma are scarce, the binding of 12 active pharmaceutical ingredients (APIs; acidic, basic, and neutral) to rainbow trout (Oncorhynchus mykiss) and human plasma was measured using solid-phase microextraction (SPME). The plasma/water distribution ratios (D plasma/w) of neutral and basic APIs were similar for trout and human plasma, differing by no more than a factor of 2.7 for a given API. For the acidic APIs, the D plasma/w values of trout plasma were much lower than for human plasma, by up to a factor of 71 for naproxen. The lower affinity of the acidic APIs to trout plasma compared with human plasma suggests that the bioavailability of these APIs is higher in trout. Read-across approaches like the fish plasma model should account for differences in plasma protein binding to avoid over- or underestimation of effects in fish. For the acidic APIs, the effect ratio of the fish plasma model would increase by a factor of 5 to 60 if the unbound plasma concentrations were used to calculate the effect ratio. Environ Toxicol Chem 2022;41:559–568. © 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Abstract Neutral and basic pharmaceuticals showed similar binding to trout and human blood plasma. Acidic pharmaceuticals (e.g., naproxen) bind to trout plasma with a lower affinity, suggesting a higher bioavailability of these pharmaceuticals in trout than in human plasma.
Theoretical and Methodological Considerations for Research on Eating Disorders and Gender
2020-11-17

Gender is a relevant factor in the etiology of eating disorders (ED) as evidenced by gender-specific components of disordered eating and by the high risk of ED among transgender individuals, in addition to other factors. However, research on connections between ED and gender identity are limited. Researchers who produce explanatory models, content themselves with faulting the sociocultural ideal of slimness for women, but they fail to grasp the connection between culture, gender and the body and they fall short of integrating this perspective into existing psychological knowledge about ED. Psychological research informed by feminist theory has begun to bridge this gap, but this growing area of research needs to be further developed and should include an understanding of ED in persons with all gender identities. This article expands the discussion of gender and ED, by grounding ED in an understanding of gender itself and by discussing methodological implications of this understanding.
ABA-Dependent Salt Stress Tolerance Attenuates Botrytis Immunity in Arabidopsis
2020-11-17

Plants have evolved adaptive measures to cope with abiotic and biotic challenges simultaneously. Combinatorial stress responses require environmental signal integration and response prioritization to balance stress adaptation and growth. We have investigated the impact of salt, an important environmental factor in arid regions, on the <i>Arabidopsis</i> innate immune response. Activation of a classical salt stress response resulted in increased susceptibility to infection with hemibiotrophic <i>Pseudomonas syringae</i> or necrotrophic <i>Alternaria brassicicola</i>, and <i>Botrytis cinerea</i>, respectively. Surprisingly, pattern-triggered immunity (PTI)-associated responses were largely unaffected upon salt pre-treatment. However, we further observed a strong increase in phytohormone levels. Particularly, abscisic acid (ABA) levels were already elevated before pathogen infection, and application of exogenous ABA substituted for salt-watering in increasing <i>Arabidopsis</i> susceptibility toward <i>B. cinerea</i> infection. We propose a regulatory role of ABA in attenuating <i>Botrytis</i> immunity in this plant under salt stress conditions.