julilili42/papers huggingface dataset:
Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-kappa B in the induction of cell death in dendritic cells and macrophages
2008-01-17

Yersinia outer protein P (YopP) induces cell death in macrophages and dendritic cells (DC). In DC this YopP-dependent cell death coincides with the inhibition of nuclear factor-kappa B (NF- κ B) activation. However, as shown by measurement of propidium iodide uptake via disrupted cellular membranes, the preincubation of DC with several NF- κ B inhibitors prior to infection with Yersinia did not restore the death-inducing capacity of a YopP-deficient Yersinia mutant. These results suggest that in contrast to macrophages, in DC the YopP-dependent inhibition of NF- κ B activation is not causative for the induction of cell death. Instead, in DC, the inhibition of mitogen-activated protein kinases (MAPKs), in particular, p38 and c-Jun N-terminal kinase, prior to infection with a YopP-deficient Yersinia mutant substituted the death-inducing capacity of the Yersinia wild-type strain, indicating that the YopP-dependent inhibition of MAPKs mediates Yersinia -induced DC death. The differences between DC and macrophages in the mechanisms of cell death induction by YopP presented herein might be crucial for the function of these antigen-presenting cells.
Behavioural response to interference competition in a sessile suspension feeder
2008-01-17

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 353:131-135 (2008) - DOI: https://doi.org/10.3354/meps07204 Behavioural response to interference competition in a sessile suspension feeder Antonius Gagern*, Timo Schürg, Nico K. Michiels, Gregor Schulte, Dennis Sprenger, Nils Anthes Animal Evolutionary Ecology, Zoological Institute, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany *Email: antonius.gagern@gmail.com ABSTRACT: The sessile suspension-feeding worm-snail Dendropoma maxima Sowerby, 1825 (Vermetidae) secretes a mucous web to capture planktonic prey. In dense groups, the feeding webs of neighbouring snails frequently overlap and stick together. This may create direct food competition between neighbours because the earlier retracting snail may get more than its fair share of the prey. While field observations indicate that web overlap may generate retarded growth, we experimentally studied whether web overlap also triggers a phenotypic response in feeding behaviour. In our experiment we consecutively placed focal snails in a place by themselves (solitary) or close to a neighbouring snail such that webs overlapped, starting with either of the 2 conditions in half of the experimental individuals to exclude sequence effects. We found that focals retracted their feeding web significantly earlier when close to a neighbour than when solitary. Our experiments thus confirm a phenotypic response through early web retraction in D. maxima, indicating that direct interference competition affects worm-snail behaviour. KEY WORDS: Phenotypic plasticity · Food competition · Suspension feeding · Prisoners Dilemma Full text in pdf format PreviousNextCite this article as: Gagern A, Schürg T, Michiels NK, Schulte G, Sprenger D, Anthes N (2008) Behavioural response to interference competition in a sessile suspension feeder. Mar Ecol Prog Ser 353:131-135. https://doi.org/10.3354/meps07204 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 353. Online publication date: January 17, 2008 Print ISSN: 0171-8630; Online ISSN: 1616-1599 Copyright © 2008 Inter-Research.
Up‐regulation of hypertonicity‐activated myo‐inositol transporter SMIT1 by the cell volume‐sensitive protein kinase SGK1
2008-01-18

Mechanisms of regulatory cell volume increase following cell shrinkage include accumulation of organic osmolytes such as betaine, taurine, sorbitol, glycerophosphorylcholine (GPC) and myo‐inositol. Myo‐inositol is taken up by the sodium‐myo‐inositol‐transporter SMIT1 (SLC5A3) expressed in a wide variety of cell types. Hypertonicity induces the transcription of the SMIT1 gene upon binding of the transcription factor tonicity enhancer binding protein (TonEBP) to tonicity responsive enhancers (TonE) in the SMIT1 promoter region. However, little is known about post‐translational regulation of the carrier protein. In this study we show that SMIT1 is modulated by the serum‐ and glucocorticoid‐inducible kinase SGK1, a protein genomically up‐regulated by hypertonicity. As demonstrated by two‐electrode voltage‐clamp in the Xenopus oocyte expression system, SMIT1‐mediated myo‐inositol‐induced currents are up‐regulated by coexpression of wild type SGK1 and constitutively active S422D SGK1 but not by inactive K127N SGK1. The increase in SMIT1 activity is due to an elevated cell surface expression of the carrier while its kinetic properties remain unaffected. According to the decay of SMIT1 activity in the presence of brefeldin A, SGK1 stabilizes the SMIT1 protein in the plasma membrane. The SGK isoforms SGK2, SGK3 and the closely related protein kinase B (PKB) are similarly capable of activating SMIT1 activity. SMIT1‐mediated currents are decreased by coexpression of the ubiquitin‐ligase Nedd4‐2, an effect counteracted by additional coexpression of SGK1. In conclusion, the present observations disclose SGK isoforms and protein kinase B as novel regulators of SMIT1 activity.
Electronic Nose:  Current Status and Future Trends
2008-01-19

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Nose: Current Status and Future TrendsFrank Röck, Nicolae Barsan, and Udo WeimarView Author Information Institute of Physical and Theoretical Chemistry, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany Cite this: Chem. Rev. 2008, 108, 2, 705–725Publication Date (Web):January 19, 2008Publication History Received23 August 2007Published online19 January 2008Published inissue 1 February 2008https://pubs.acs.org/doi/10.1021/cr068121qhttps://doi.org/10.1021/cr068121qresearch-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views27646Altmetric-Citations1134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Atmospheric chemistry,Chromatography,Gases,Ions,Sensors Get e-Alerts
Late desaturation due to collateral veins 10 years after total cavopulmonary shunt in left atrial isomerism: surgical closure
2008-01-19

The development of systemic collateral veins after palliative surgery in children with univentricular circulation is a common complication, however, manifestation as late as 10 years postoperatively is rare. Massive systemic to hepatic venous collaterals developed in a 14-year-old girl with univentricular heart, situs inversus atriovisceralis and hemiazygos continuity to the left-sided superior vena cava, 10 years after Kawashima operation. The resulting azygoportal shunt had led to a progressive systemic desaturation and reduction in ventricular function. Interventional occlusion was supposed to be risky for renal failure due to potential closure of the renal vein so that surgical closure was performed. The saturation persistently increased from 65% to more than 85% postoperatively.
Cryogenic vitrification and 3D serial sectioning using high resolution cryo‐FIB SEM technology for brine‐filled grain boundaries in halite: first results
2008-01-20

Abstract The structure of brine films in grain boundaries of halite has been the subject of much controversy over the past 20 years; although a number of innovative methods have been developed to study these structures, much is still unknown and fundamental information is missing. In this study, we investigated different methods of plunge‐freezing to vitrify the brine fill of grain boundaries for natural salt polycrystal. This was followed by a preliminary study of the 3D morphology of a vitrified grain boundary in a natural rock salt sample with a focused ion beam (FIB) excavation system. We have shown that brine‐filled grain boundaries in rock salt can be efficiently well frozen when dimensions are less than about 1 mm. Coupled with an ion beam tool, cryo‐SEM allows 3D observation of the well‐frozen grain boundaries in large volumes and high resolution. Initial results of brine‐filled natural halite grain boundaries show non‐faceted crystal–brine interfaces and unexpectedly low dihedral angles at room temperature and pressure.
Reduced-Intensity Conditioning followed by Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Myelodysplastic Syndrome and Myeloproliferative Disorders
2008-01-21

Allogeneic hematopoietic cell transplantation (HCT) is the only curative strategy for patients with myelodysplastic syndrome (MDS) and myeloproliferative disorders (MPD). We report the results of 148 patients (median age = 59 years old) with de novo MDS (n = 40), acute myelogenous leukemia (AML) after antecedent MDS/MPD (n = 49), treatment-related MDS (t-MDS) (n = 25), MPD (n = 27), and chronic myelomonocytic leukemia (CMML) (n = 7) who underwent allogeneic HCT using a conditioning regimen of low-dose total body irradiation (TBI) alone (200 cGy) on day 0 (n = 5) or with the addition of fludarabine (Flu) 30 mg/m(2)/day on days -4 to -2 (n = 143). Postgrafting immunosuppression consisted of cyclosporine and mycophenolate mofetil (MMF). Seventy-five patients (51%) received an allograft from a matched related donor (MRD), and 73 patients (49%) were recipients of unrelated donor (URD) grafts. There was no significant difference in the incidence of acute (gr II-IV) and chronic extensive graft-versus-host disease (aGVHD, cGVHD) between the recipients of related and unrelated donor grafts. By day +28, 75% of patients demonstrated mixed T cell chimerism. Graft rejection was seen in 15% of patients. With a median follow-up of 47 (range: 6-89) months, the 3-year relapse-free survival (RFS) and overall survival (OS) are both 27% for all patients, with a relapse incidence of 41%. The 3-year RFS for the patients with de novo MDS, AML after antecedent MDS/MPD, t-MDS, MPD, and CMML were 22%, 20%, 29%, 37%, and 43%, respectively, and the 3-year OS was 20%, 23%, 27%, 43%, and 43%, respectively. The 3-year nonrelapse mortality (NRM) was 32%. Factors associated with a lower risk of relapse were the development of extensive cGVHD and having a low risk or intermediate-1 risk International Prognostic Score for the de novo MDS patients. Nonmyeloablative HCT confers remissions in patients who otherwise were not eligible for conventional HCT but for whom relapse is the leading cause of treatment failure.
Cryo‐section immunolabelling of difficult to preserve specimens: advantages of cryofixation, freeze‐substitution and rehydration
2008-01-21

Background information . Electron microscopic immunolabelling of ultrathin thawed cryo‐sections, according to the method of Tokuyasu, is widely used as a very sensitive high‐resolution localization technique. Its main advantages are that antigens remain in a hydrated environment prior to immunolabelling, and that antigen accessibility is improved compared with resin section labelling. However, the quality of structural appearance and antigenicity depends highly on the limitations of the initial conventional chemical fixation step, such as slow diffusion and selective reaction/cross‐linking of fixative molecules. Results and conclusions . Cryofixation, instead of conventional chemical fixation, followed by freeze‐substitution/chemical fixation, rehydration and further processing for Tokuyasu cryo‐sectioning leads to an improved preservation of both ultrastructure and antigenicity. This is especially true for tissues which are difficult to preserve by conventional chemical fixation at ambient temperatures, such as plant material, Drosophila embryos or nematode tissue. In particular labile and highly dynamic structures (for example, microtubules and Golgi apparatus) are remarkably better preserved. These improvements are also valid for light microscopic applications.
Ketamine aggravates symptoms of acute stress disorder in a naturalistic sample of accident victims
2008-01-22

The glutamatergic N-methyl-D-aspartate receptor antagonist ketamine produces transient dissociative states and alters cognitive functioning in healthy humans, thus resembling the core symptoms of acute and chronic post-traumatic stress disorder (PTSD). First evidence exists that the common use of the analgesic and sedative properties of ketamine during emergency care correlates with sustained symptoms of PTSD in accident victims. The aim of the present study was to examine whether ketamine administration after moderate accidental trauma modulates dissociation and other symptoms of acute stress disorder (ASD) in the direct aftermath of the event. Accident victims were screened within the third day after admission to hospital for symptoms of ASD (Peritraumatic Dissociative Experiences Questionnaire, ASD Scale) and prior stressful life events (Traumatic Life Events Questionnaire). Subjects had received a single or fractionated dose of either racemic ketamine (n = 13), opioids (n = 24) or non-opioid analgesics (n = 13) during initial emergency treatment. There were no significant differences between medication groups in demographic and clinical characteristics such as injury severity or prior traumatization. With respect to ASD symptomatology three days post-event there were significant associations between ketamine analgosedation and increased symptoms of dissociation, reexperiencing, hyperarousal and avoidance relative to the comparison groups.Growing evidence exists that ketamine might modulate or aggravate early post-traumatic stress reactions when given in the acute trauma phase, which in turn might contribute to long-lasting symptomatology.
Antithrombotic therapy after bioprosthetic aortic valve replacement: ACTION Registry survey results☆
2008-01-22

This study demonstrates that, despite guidelines published by several professional societies, medical practice for the prevention of thrombotic events early after bioprosthetic AVR varies widely among cardiac surgical centers.
A universal constraint between charge and rotation rate for degenerate black holes surrounded by matter
2008-01-22

We consider stationary, axially and equatorially symmetric systems consisting of a central rotating and charged degenerate black hole and surrounding physically realistic matter. We show that always holds, where is the black hole's intrinsic angular momentum per unit mass, its electric charge and the well known black hole mass parameter introduced by Christodoulou and Ruffini.
Effect of Surface Andreev Bound States on the Bean-Livingston Barrier ind-Wave Superconductors
2008-01-22

We study the influence of surface Andreev bound states in d-wave superconductors on the Bean-Livingston surface barrier for entry of a vortex line into a strongly type-II superconductor. Starting from Eilenberger theory, we derive a generalization of London theory to incorporate the anomalous surface currents arising from the Andreev bound states. This allows us to find an analytical expression for the modification of the Bean-Livingston barrier in terms of a single parameter describing the influence of the Andreev bound states. We find that the field of first vortex entry is significantly enhanced. Also, the depinning field for vortices near the surface is renormalized. Both effects are temperature dependent and depend on the orientation of the surface relative to the d-wave gap.
Intracellular cytokine patterns in Behçet's disease in comparison to ankylosing spondylitis--influence of treatment with interferon-alpha2a.
2008-01-22

In BD and AS, CD3+ and CD4+ T-cells producing IL 2 are reduced. This may hint at a similarity in the pathogenesis of these HLA-class I-associated disorders. IFN-alpha2a induces restoration of IL 2-production in patients with BD which is likely to be one mechanism of action of IFN-alpha2a.
Interference of an array of atom lasers
2008-01-22

We report on the observation of interference of a series of atom lasers. A\\ncomb-like array of coherent atomic beams is generated by outcoupling atoms from\\ndistinct Bose-Einstein condensates confined in the independent sites of a\\nmesoscopic optical lattice. The observed interference signal arises from the\\nspatial beating of the overlapped atom laser beams, which is sampled over a\\nvertical region corresponding to 2 ms of free fall time. The average relative\\nde Broglie frequency of the atom lasers was measured.\\n
Faculty Opinions recommendation of The ischemic optic neuropathy decompression trial.
2008-01-22

No abstract available PMID: 17998521 Funding information This work was supported by: NEI NIH HHS, United States Grant ID: P30-EY06360 NEI NIH HHS, United States Grant ID: EY09626 NEI NIH HHS, United States Grant ID: EY09608 NEI NIH HHS, United States Grant ID: EY09599 NEI NIH HHS, United States Grant ID: EY09598 NEI NIH HHS, United States Grant ID: EY09584 NEI NIH HHS, United States Grant ID: EY09582 NEI NIH HHS, United States Grant ID: EY09579 NEI NIH HHS, United States Grant ID: EY09578 NEI NIH HHS, United States Grant ID: EY09576 NEI NIH HHS, United States Grant ID: EY09575 NEI NIH HHS, United States Grant ID: EY09572 NEI NIH HHS, United States Grant ID: EY09571 NEI NIH HHS, United States Grant ID: EY09570 NEI NIH HHS, United States Grant ID: EY09569 NEI NIH HHS, United States Grant ID: EY09568 NEI NIH HHS, United States Grant ID: EY09567 NEI NIH HHS, United States Grant ID: EY09566 NEI NIH HHS, United States Grant ID: EY09565 NEI NIH HHS, United States Grant ID: EY09557 NEI NIH HHS, United States Grant ID: EY09556 NEI NIH HHS, United States Grant ID: EY09555 NEI NIH HHS, United States Grant ID: EY09554 NEI NIH HHS, United States Grant ID: EY09553 NEI NIH HHS, United States Grant ID: EY09552 NEI NIH HHS, United States Grant ID: EY09551 NEI NIH HHS, United States Grant ID: EY09550 NEI NIH HHS, United States Grant ID: EY09545 More Less keyboard_arrow_down
Hand Movement Direction Decoded from MEG and EEG
2008-01-23

Brain activity can be used as a control signal for brain–machine interfaces (BMIs). A powerful and widely acknowledged BMI approach, so far only applied in invasive recording techniques, uses neuronal signals related to limb movements for equivalent, multidimensional control of an external effector. Here, we investigated whether this approach is also applicable for noninvasive recording techniques. To this end, we recorded whole-head MEG during center-out movements with the hand and found significant power modulation of MEG activity between rest and movement in three frequency bands: an increase for ≤7 Hz (low-frequency band) and 62–87 Hz (high-γ band) and a decrease for 10–30 Hz (β band) during movement. Movement directions could be inferred on a single-trial basis from the low-pass filtered MEG activity as well as from power modulations in the low-frequency band, but not from the β and high-γ bands. Using sensors above the motor area, we obtained a surprisingly high decoding accuracy of 67% on average across subjects. Decoding accuracy started to rise significantly above chance level before movement onset. Based on simultaneous MEG and EEG recordings, we show that the inference of movement direction works equally well for both recording techniques. In summary, our results show that neuronal activity associated with different movements of the same effector can be distinguished by means of noninvasive recordings and might, thus, be used to drive a noninvasive BMI.
4-(4-Fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one
2008-01-23

The crystal structure of the title compound, C(15)H(11)FN(2)O(3), was determined as part of a study on the biological activity of isoxazolone derivatives as p38 mitogen-activated protein kinase (MAPK) inhibitors. The dihedral angles between rings are isoxazole/benzene = 55.0 (3)°, isoxazole/pyridine = 33.8 (2)° and benzene/pyridine = 58.1 (2)°.
Multiplexed Immunoassays for Protein Profiling in Human Body Fluids
2008-01-23

This chapter describes the development and use of suspension antibody microarrays for protein profiling in several human body fluids. In suspension microarrays, which allow the simultaneous analysis of a variety of analytes within a single experiment, capture antibodies are coupled onto color-coded microspheres. Applications are described, with emphasis on analyses of proteins present in different types of body fluids, like serum or plasma, tears, cerebrospinal, pleural, and synovial fluids, and cell culture supernatants. The chapter is divided into the generation of suspension microarrays, sample preparation, processing, and validation of analytical performance.
Magnetic resonance guidance for radiofrequency ablation of liver tumors
2008-01-24

Abstract Image‐guided thermal ablation of liver tumors is a minimally invasive treatment option. Techniques used for thermal ablation are radiofrequency (RF) ablation, laser interstitial thermotherapy (LITT), microwave (MW) ablation, high‐intensity focused ultrasound (HIFU), and cryoablation. Among these techniques RF ablation attained widespread consideration. Image guidance should ensure a precise ablation therapy leading to a complete coagulation of tumor tissue without injury to critical structures. Therefore, the modality of image guidance has an important impact on the safety and efficacy of percutaneous RF ablation. The current literature regarding percutaneous RF ablation mainly describes the use of computed tomography (CT) and ultrasonography (US) guidance. In addition, interventional MR systems offer the possibility to utilize the advantages of MR imaging such as excellent soft‐tissue contrast, multiplanar and interactive capabilities, and sensitivity to thermal effects during the entire RF ablation procedure. Monitoring of thermally induced coagulation by MR imaging is supportive to control the ablation procedure. MR imaging can be advantageously used to guide overlapping ablation if necessary as well as to define the endpoint of RF ablation after complete coverage of the target tissue is verified. Furthermore, monitoring of thermal effects is essential in order to prevent unintended thermal damage from critical structures surrounding the target region. Therefore, MR‐guided RF ablation offers the possibility for a safe and effective therapy option in the treatment of primary and secondary hepatic malignancies. The article summarizes the role of MR guidance for RF ablation of liver tumors. J. Magn. Reson. Imaging 2008;27:421–433. © 2008 Wiley‐Liss, Inc.
The Role of Positron Emission Tomography in the Evaluation of Residual Masses After Chemotherapy for Advanced Stage Seminoma
2008-01-24

Our data indicate that FDG-positron emission tomography is capable of excluding viable disease in residual masses, even those exceeding 3 cm. Therefore, it may be considered an additional tool to improve patient counseling. However, the decision to perform surgical resection of the residual mass should not be based exclusively on a positive positron emission tomography image since false-positive results appear to be common.