julilili42/papers huggingface dataset:
European Guidelines (S1) on the use of high‐dose intravenous immunoglobulin in dermatology
2016-12-30

Summary Background and objectives Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high‐dose intravenous immunoglobulin (IVIg) is a well‐established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence‐based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future. Because first‐line use is limited by the high costs of IVIg, the first clinical guidelines on the use of IVIg in dermatological conditions were established in 2008 and renewed in 2011. Methods The European guidelines presented here were prepared by a panel of experts nominated by the EDF and EADV. The guidelines were developed to update the indications for treatment currently considered effective and to summarize the evidence for the use of IVIg in dermatological autoimmune diseases and TEN. Results and conclusion The current guidelines represent consensual expert opinions and definitions on the use of IVIg reflecting current published evidence and are intended to serve as a decision‐making tool for the use of IVIg in dermatological diseases.
"Faces of Evil in Modern Fantasy"
2016-12-30

Fantasy literature has enjoyed a vast increase in cultural prominence in the last quarter-century. What was once considered a marginal genre of scant literary merit is now enormously popular, enjoying huge sales and steadily increasing critical respectability. This change is partly due to the fashion in the early years of this century for cinematic adaptations of fantasy novels. Film “franchises” such as The Lord of the Rings and Harry Potter sold tens of millions of tickets apiece and prompted sympathetic reappraisals of their source material among both popular and academic audiences. Though this trend seemed to have run its course by about 2010, the television show Game of Thrones (2011-present) appears to have taken it to a new level. After six seasons the show continues to break ratings records and seems likely to be remembered as part of the zeitgeist of this decade. This success has naturally prompted renewed interest in George R.R. Martin’s A Song of Ice and Fire, the series of novels on which the show is based. Recent editions of Martin’s books have become runaway bestsellers and the forthcoming installments will no doubt do the same. Martin has also become a success with the critics, who praise the complexity of his characters and the moral depth of his work. Long-time readers and scholars of fantasy obviously welcome this.
From macro to micro: universal properties of neutron stars
2016-12-30

A recent discovery has pointed out that the moment of inertia, the tidal Love number and the spin- induced quadrupole moment of a neutron star, are linked together by semi-analytic relations which are almost insensitive to the star equations of state. These I-Love-Q relations open the opportunity to combine gravitational and electromagnetic observations and to devise new strategies, which will provide a better insight on the neutron star structure and the nature of gravity in the strong field regime. In this paper we review the main features of these universal relations, studying four scenarios in which they have been analysed to extend their domain of validity. We focus first on compact binaries close to the coalescence. Then, we investigate how strong magnetic fields, fast rotation, and hot equations of state affect the I-Love-Q universality
Collectives, object mass nouns and individual count nouns
2016-12-31

Mass superordinates such as clothing, clothes and furniture form a distinct and peculiar class of nouns in languages with an obligatory singular/plural distinction. These nouns often have pluralia-tantum variants as well as count equivalents – both within one linguistic system as well as cross-linguistically. This study is a follow-up of my earlier analysis of Romance superordinates ( Mihatsch, 2006 ). The data are taken from English, German, French and Spanish in order to demonstrate the striking cross-linguistic pattern. The highly variable Spanish ropa(s) ‘clothing/clothes’ is analysed in greater detail. I argue that in most cases the apparently unsystematic synchronic variants arise from partly unidirectional diachronic changes, namely a lexicalisation process leading from collective nouns to object mass nouns, often followed by the appearance of plural forms, which oscillate between a lexical and an inflectional plural.
»Vulnerable Families«: Reflections on a Difficult Category
2016-12-31

The term “vulnerable families” refers to familial living situations that are considered problematic, with a particular need for socially responsible, professionally provided support. This means of categorising families is extremely ambivalent, indicating not only a need for society to support forms of family life and family achievements, but also a particular need to protect children growing up within the family. It also has implications for an understanding of interventions geared to the riskiness of family living situations and their standardisation, an understanding that risks losing sight of families’ variety and individual peculiarities. Families in need of support have a fundamental right for their individuality and parenthood to be recognised. A detailed case analysis of a social worker who is working with a family in which a child’s wellbeing is at risk shows how transferring standardising ideas about the family can damage that basic right. The article thus calls for the category of vulnerability to be applied to families with reflection on the specific case and on implicit normative leanings.
How to Stop Cognitive Processes is as Important as How to Start Them. Commentary on Dipoppa et al.
2016-12-31

We are used to dealing with concepts which provide explanations for how cognitive processes are initiated. But we hardly ever spend time on trying to explain how such processes are turned off again and, thus, do not compromise subsequent processes.
A White Paper on keV sterile neutrino Dark Matter
2017-01-01

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved—cosmology, astrophysics, nuclear, and particle physics—in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.
CoNLL 2017 Shared Task: Multilingual Parsing from Raw Text to Universal Dependencies
2017-01-01

The Conference on Computational Natural Language Learning (CoNLL) features a shared task, in which participants train and test their learning systems on the same data sets. In 2017, one of two tasks was devoted to learning dependency parsers for a large number of languages, in a real world setting without any gold-standard annotation on input. All test sets followed a unified annotation scheme, namely that of Universal Dependencies. In this paper, we define the task and evaluation methodology, describe data preparation, report and analyze the main results, and provide a brief categorization of the different approaches of the participating systems.
The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
2017-01-01

We report the observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ~0.1 count /(FWHM·t·yr) in the region of the signal. The current generation &lt;sup&gt;76&lt;/sup&gt;Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale &lt;sup&gt;76&lt;/sup&gt;Ge experiment. Lastly, the collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 10&lt;sup&gt;28&lt;/sup&gt; years, using existing resources as appropriate to expedite physics results.
Ready for Take-Over? A New Driver Assistance System for an Automated Classification of Driver Take-Over Readiness
2017-01-01

Recent studies analyzing driver behavior report that various factors may influence a driver's take-over readiness when resuming control after an automated driving section. However, there has been little effort made to transfer and integrate these findings into an automated system which classifies the driver's take-over readiness and derives the expected take-over quality. This study now introduces a new advanced driver assistance system to classify the driver's takeover readiness in conditionally automated driving scenarios. The proposed system works preemptively, i.e., the driver is warned in advance if a low take-over readiness is to be expected. The classification of the take-over readiness is based on three information sources: (i) the complexity of the traffic situation, (ii) the current secondary task of the driver, and (iii) the gazes at the road. An evaluation based on a driving simulator study with 81 subjects showed that the proposed system can detect the take-over readiness with an accuracy of 79%. Moreover, the impact of the character of the take-over intervention on the classification result is investigated. Finally, a proof of concept of the novel driver assistance system is provided showing that more than half of the drivers with a low take-over readiness would be warned preemptively with only a 13% false alarm rate.
The Zipfian Paradigm Cell Filling Problem
2017-01-01

This chapter proposes that the stable coexistence of regular and irregular patterns can be understood in terms of a trade-off between the opposing communicative pressures imposed by predictability and discriminability. On this view, irregularity is not ‘defective’ or ‘anomalous’. Instead, irregular formations exhibit an enhanced discriminability that brings them into maximal conformance with precepts like the ‘one form-one meaning principle’, while allowing them to act as attractors within a larger system. Conversely, regularity is neither ‘optimal’ nor ‘normative’. Regular patterns serve to facilitate predictability within a system. In order for regular items to perform this function, it must be possible to assign partially attested paradigms that exhaust the variation in the system. We suggest that a correlation between lexical neighbourhoods and patterns of co-filled cells bootstraps this analogical process.
Multicenter stability of resting state fMRI in the detection of Alzheimer's disease and amnestic MCI
2017-01-01

Multicenter rs-fMRI analysis needs to employ strict quality measures, including visual inspection of all the data, to avoid seriously confounded group effects. While pending further confirmation in biomarker stratified samples, these findings suggest that multicenter acquisition limits the use of rs-fMRI in AD and MCI diagnosis.
Spatially composition-modulated two-dimensional WS2xSe2(1−x)nanosheets
2017-01-01

Controllable synthesis of two-dimensional (2D) transition-metal dichalcogenides (TMDs) with tunable bandgaps is vital for their applications in nanophotonics, due to its efficient modulation of the physical and chemical properties of these atomic layered nanostructures. Here we report for the first time, the controllable synthesis of spatially composition-modulated WS<sub>2x</sub>Se<sub>2(1-x)</sub> nanosheets and WS<sub>2</sub>-WS<sub>2x</sub>Se<sub>2(1-x)</sub> lateral heterostructures by a developed one-step chemical vapor deposition (CVD) approach, as well as the understanding of their growth mechanism. During the growth, the composition was optically tuned along the plane of the atomic layered nanosheets through the precise control of evaporation sources. Microstructure characterization confirms the chemical identity of the composition modulated nanosheets, with S and Se contents gradually converting from the center to the edge. Local photoluminescence (PL) and Raman studies further demonstrate the position-dependent optical properties of the as-grown nanosheets, with the PL peak and Raman modes shifting in a wide range along the whole plane of the nanostructures, which are consistent with their tunable compositions and bandgaps. This demonstration of composition-modulated nanostructures provides a beneficial approach for the preparation of 2D semiconductor heterostructures and may open up a wide range of applications in nanoelectronics and optoelectronics.
Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo
2017-01-01

Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy or bone marrow transplant patients caused by the ubiquitous environmental fungus <i>Aspergillus fumigatus</i>. Current diagnostic tests for the disease lack sensitivity as well as specificity, and culture of the fungus from invasive lung biopsy, considered the gold standard for IPA detection, is slow and often not possible in critically ill patients. In a previous study, we reported the development of a novel non-invasive procedure for IPA diagnosis based on antibody-guided positron emission tomography and magnetic resonance imaging (immunoPET/MRI) using a [<sup>64</sup>Cu]DOTA-labeled mouse monoclonal antibody (mAb), mJF5, specific to <i>Aspergillus</i>. To enable translation of the tracer to the clinical setting, we report here the development of a humanised version of the antibody (hJF5), and pre-clinical imaging of lung infection using a [<sup>64</sup>Cu]NODAGA-hJF5 tracer. The humanised antibody tracer shows a significant increase in <i>in vivo</i> biodistribution in <i>A. fumigatus</i> infected lungs compared to its radiolabeled murine counterpart [<sup>64</sup>Cu]NODAGA-mJF5. Using reverse genetics of the pathogen, we show that the antibody binds to the antigenic determinant β1,5-galactofuranose (Gal<i>f</i>) present in a diagnostic mannoprotein antigen released by the pathogen during invasive growth in the lung. The absence of the epitope Gal<i>f</i> in mammalian carbohydrates, coupled with the enhanced imaging capabilities of the hJF5 antibody, means that the [<sup>64</sup>Cu]NODAGA-hJF5 tracer developed here represents an ideal candidate for the diagnosis of IPA and translation to the clinical setting.
Eryptosis - the Neglected Cause of Anemia in End Stage Renal Disease
2017-01-01

End stage renal disease (ESRD) invariably leads to anemia which has been mainly attributed to compromised release of erythropoietin from the defective kidneys with subsequent impairment of erythropoiesis. However, erythropoietin replacement only partially reverses anemia pointing to the involvement of additional mechanisms. As shown more recently, anemia of ESRD is indeed in large part a result of accelerated erythrocyte loss due to suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the cell surface. Phosphatidylserine exposing erythrocytes are bound to and engulfed by macrophages and are thus rapidly cleared from circulating blood. If the loss of erythrocytes cannot be fully compensated by enhanced erythropoiesis, stimulation of eryptosis leads to anemia. Eryptotic erythrocytes may further adhere to the vascular wall and thus impair microcirculation. Stimulators of eryptosis include complement, hyperosmotic shock, energy depletion, oxidative stress, and a wide variety of xenobiotics. Signaling involved in the stimulation of eryptosis includes increase of cytosolic Ca&lt;sup&gt;2+&lt;/sup&gt; activity, ceramide, caspases, calpain, p38 kinase, protein kinase C, Janus-activated kinase 3, casein kinase 1α, and cyclin-dependent kinase 4. Eryptosis is inhibited by AMP-activated kinase, p21-activated kinase 2, cGMP-dependent protein kinase, mitogen- and stress-activated kinase MSK1/2, and some illdefined tyrosine kinases. In ESRD eryptosis is stimulated at least in part by a plasma component, as it is triggered by exposure of erythrocytes from healthy individuals to plasma from ESRD patients. Several eryptosis-stimulating uremic toxins have been identified, such as vanadate, acrolein, methylglyoxal, indoxyl sulfate, indole-3-acetic acid and phosphate. Attempts to fully reverse anemia in ESRD with excessive stimulation of erythropoiesis enhances the number of circulating suicidal erythrocytes and bears the risk of interference with micocirculation, At least in theory, anemia in ESRD could preferably be treated with replacement of erythropoietin and additional inhibition of eryptosis thus avoiding eryptosis-induced impairment of microcirculation. A variety of eryptosis inhibitors have been identified, their efficacy in ESRD remains, however, to be shown.
Protease-Activated Receptor PAR-4: An Inducible Switch between Thrombosis and Vascular Inflammation?
2017-01-01

Abstract Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncontrolled PAR activation, however, can prevent timely resolution of inflammation, enhance thrombogenic endothelial function and drive adverse remodelling. The specific role of PAR-4 in thromboinflammatory vascular disease has been largely underestimated, given the relatively limited expression of PAR-4 in non-platelet cells under healthy conditions. However, unlike PAR-1, PAR-4 expression adapts dynamically to numerous stimuli associated with thromboinflammation, including thrombin, angiotensin II, sphingosine-1-phosphate (S1P), high glucose and redox stress, suggesting expression is switched on ‘at need’. Prostacyclin negatively regulates PAR-4 expression at the post-transcriptional level, which may serve to fine-tune thrombin responses and limit these to the injury site. PAR-4 elicits inflammatory, mitogenic and proliferative actions not only in response to thrombin but also to numerous other inflammatory proteases, and can cross-talk with other receptor systems such as S1P and adenosine receptors. Accordingly, PAR-4 has emerged as a candidate player in vessel disease and cardiac post-infarction remodelling. Currently, PAR-4 is a particularly promising target for safer anti-thrombotic therapies. Recent studies with the PAR-4 antagonist BMS-986120 lend support to the concept that selective antagonism of PAR-4 may offer both an effective and safe anti-thrombotic therapy in the acute thrombotic setting as well as an anti-inflammatory strategy to prevent long-term progressive atherosclerotic disease in high-risk cardiovascular patients.
Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers
2017-01-01

Background/Aims: Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT) has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms. Methods: We performed cell proliferation and migration assays, FACS- and Western blot analyses, RT-PCR, and Affymetrix gene expression analyses on human keratinocytes and fibroblasts, and a tube formation assay on human microvascular endothelial cells to assess the impact of shock waves in vitro. In vivo, chronic therapy-refractory leg ulcers were treated with ESWT, and wound healing was assessed. Results: Upon ESWT, we observed morphological changes and increased cell migration of keratinocytes. Cell-cycle regulatory genes were upregulated, and proliferation induced in fibroblasts. This was accompanied by secretion of pro-inflammatory cytokines from keratinocytes, which are known to drive wound healing, and a pro-angiogenic activity of endothelial cells. These observations were transferred “from bench to bedside”, and 60 consecutive patients with 75 CLUs with different pathophysiologies (e.g. venous, mixed arterial-venous, arterial) were treated with ESWT. In this setting, 41% of ESWT-treated CLUs showed complete healing, 16% significant improvement, 35% improvement, and 8% of the ulcers did not respond to ESWT. The induction of healing was independent of patient age, duration or size of the ulcer, and the underlying pathophysiology. Conclusions: The efficacy of ESWT needs to be confirmed in controlled trials to implement ESWT as an adjunct to standard therapy or as a stand-alone treatment. Our results suggest that EWST may advance the treatment of chronic, therapy-refractory ulcers.