julilili42/papers huggingface dataset:
Change by (almost) all means: The role of conspiracy mentality in predicting support for social change among the political left and right
2023-09-23

Abstract Right‐wing movements across the globe call for system‐changing actions. This development contradicts the typically assumed resistance to change among the political right. Many of these movements use conspiracist rhetoric and, thus, we reasoned that conspiracy mentality might be associated with the striving for system change—especially on the political right. In four cross‐sectional studies in Germany (one nationally quota‐balanced, one preregistered; total N = 1539) we found that high conspiracy mentality was related to support for social change among the right and to support for reactionary social change among the left. Support for change among those high in conspiracy mentality was diminished when elected representatives (vs the population) were thought to drive social change. These results suggest that both right wingers and left wingers high in conspiracy mentality support change in ways that are seemingly incompatible with their political orientation.
Targeting GD2 after allogeneic SCT: effector cell composition defines the optimal use of ch14.18 and the bispecific antibody construct NG-CU (GD2-CD3)
2023-09-24

Abstract We investigated whether T cell-recruiting bispecific anti-CD3/GD2 antibody NG-CU might be an alternative to therapeutic anti-GD2 monoclonal antibody (mAb) ch14.18, mediating complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) through natural killer (NK) cells for immunotherapy in high-risk/relapsed neuroblastoma after autologous/allogeneic stem cell transplantation (auto/alloSCT). Different antibody concentrations and effector-to-target ratios ( E:T ) were evaluated using xCELLigence RTCA system, peripheral blood mononuclear cells (PBMCs) (healthy donors and patients after alloSCT), and neuroblastoma cell lines (LS/LAN-1). Mean specific lysis of LS cells utilizing PBMCs from healthy donors and ch14.18 (1 μg/ml) was 40/66/75% after 12/24/48 h compared to 66/93/100% in the presence of NG-CU (100 ng/ml). NG-CU showed enhanced cytotoxicity compared to ch14.18, even at lower concentrations and E : T ratios, and completely eradicated LS cells after 72 h. To decipher the influence of effector cell subsets on lysis, different ratios of T and NK cells were tested. At a ratio of 1:1, ch14.18 was more effective than NG-CU. Using patient PBMCs taken at different time points posttransplant, significant lysis with both constructs was detectable depending on percentages and total numbers of T and NK cells; in the early posttransplant phase, NK cells were predominant and ch14.18 was superior, whereas later on, T cells represented the majority of immune cells and NG-CU was more effective. Our study highlights the importance of analyzing effector cell subsets in patients before initiating antibody-based therapy. Consequently, we propose an adjusted administration of both antibody constructs, considering the state of posttransplant immune recovery, to optimize anti-tumor activity.
Prognostic Role of KRAS G12C Mutation in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
2023-09-25

KRAS G12C mutation (mKRAS G12C) is the most frequent KRAS point mutation in non-small cell lung cancer (NSCLC) and has been proven to be a predictive biomarker for direct KRAS G12C inhibitors in advanced solid cancers. We sought to determine the prognostic significance of mKRAS G12C in patients with NSCLC using the meta-analytic approach. A protocol is registered at the International Prospective Register for systematic reviews (CRD42022345868). PubMed, EMBASE, The Cochrane Library, and Clinicaltrials.gov.in were searched for prospective or retrospective studies reporting survival data for tumors with mKRAS G12C compared with either other KRAS mutations or wild-type KRAS (KRAS-WT). The hazard ratios (HRs) for overall survival (OS) or Disease-free survival (DFS) of tumors were pooled according to fixed or random-effects models. Sixteen studies enrolling 10,153 participants were included in the final analysis. mKRAS G12C tumors had poor OS [HR, 1.42; 95% CI, 1.10–1.84, p = 0.007] but similar DFS [HR 2.36, 95% CI 0.64–8.16] compared to KRAS-WT tumors. Compared to other KRAS mutations, mKRAS G12C tumors had poor DFS [HR, 1.49; 95% CI, 1.07–2.09, p &lt; 0.0001] but similar OS [HR, 1.03; 95% CI, 0.84–1.26]. Compared to other KRAS mutations, high PD-L1 expression (&gt;50%) [OR 1.37 95% CI 1.11–1.70, p = 0.004] was associated with mKRAS G12C tumors. mKRAS G12C is a promising prognostic factor for patients with NSCLC, negatively impacting survival. Prevailing significant heterogeneity and selection bias might reduce the validity of these findings. Concomitant high PD-L1 expression in these tumors opens doors for exciting therapeutic potential.
Antibiotic prophylaxis and surgical site infections in orthognathic surgery – a retrospective analysis
2023-09-25

Abstract Background This study was conducted to determine surgical site infection (SSI) rates and potential risk factors as well as to evaluate antibiotic prophylaxis in orthognathic surgery. Methods This retrospective observational study included patients who received orthognathic surgery. SSIs and their management were assessed for up to one year post-operatively. The applied antibiotic regime and other possible influencing factors (smoking, age, site of infection, drainage, duration of surgery, displacement distances, craniofacial malformations) were assessed. Results In total 291 patient met the inclusion criteria (56.7% female). The mean age at surgery was 25.5 ± 8.5 years. Fifty-four patients (18.6%) were diagnosed with a craniofacial malformation. Relevant previous surgeries were documented in about one quarter of included patients ( n = 75). Ninety-two percent of patients ( n = 267) received intraoperative single-dose antibiotic prophylaxis. Surgical site infections occurred in 12.4% ( n = 36) of patients. There was a significant association between postoperative infections and type of surgery ( P = .037) as well as type of drainage ( P = .002). Statistical analyses also revealed a higher prevalence of smokers ( P = .036) and previous surgically assisted rapid palatal expansion (SARPE) ( P = .018) in the infection group. Furthermore, no significant relationships were observed between postoperative infections and various co-factors (i.e. antibiotic regime, age at surgery, gender, associated craniofacial malformations, surgery duration, displacement distances, mandibular setback vs. advancement). Conclusion Low rates of SSIs occurred following an intraoperative single-dose antibiotic regime. None of the SSIs had a significant effect on the final surgical outcome. Present data do not warrant escalation of the antibiotic regimen. Postoperative smoking and capillary drainage should be avoided.
Multimodal Therapy with Consolidating Haploidentical Stem Cell Transplantation and Dinutuximab Beta for Patients with High-Risk Neuroblastoma and Central Nervous System Relapse
2023-09-25

Despite highly intensive multimodality treatment regimens, the prognosis of patients with high-risk neuroblastoma (HRNB) and central nervous system (CNS) relapse remains poor. We retrospectively reviewed data from 13 patients with HRNB and CNS relapse who received multimodal therapy with consolidating haploidentical stem cell transplantation (haplo-SCT) followed by dinutuximab beta ± subcutaneous interleukin-2 (scIL-2). Following individual relapse treatment, patients aged 1−21 years underwent haplo-SCT with T/B-cell-depleted grafts followed by dinutuximab beta 20 mg/m2/day × 5 days for 5–6 cycles. If a response was demonstrated after cycle 5 or 6, patients received up to nine treatment cycles. After haplo-SCT, eight patients had a complete response, four had a partial response, and one had a stable disease. All 13 patients received ≥3 cycles of immunotherapy. At the end of the follow-up, 9/13 patients (66.7%) demonstrated complete response. As of July 2023, all nine patients remain disease-free, with a median follow-up time of 5.1 years since relapse. Estimated 5-year event-free and overall survival rates were 55.5% and 65.27%, respectively. Dinutuximab beta ± scIL-2 following haplo-SCT is a promising treatment option with a generally well-tolerated safety profile for patients with HRNB and CNS relapse.
Last three seconds: Packed message delivered by tides in binary neutron star mergers
2023-09-25

It is known that the leading-order tidal effects in gravitational waveforms can be quantified by tidal deformability, while higher order terms, e.g., harmonic overtones of Love number and dynamical tides, have not been well investigated yet. The concept of a ``form factor,'' which is different from but resembles the effective tidal deformability, for the tidal interactions between neutron stars in coalescing binaries is illustrated here. The form factor effectively incorporates the contribution of dynamical tides. The dependence of tidal form factor on tidal deformability, spins, and inclination angles is modeled and expressed in a closed form.
Framing and decoupling in global markets: a theoretical framework for the analysis of multiple markets
2023-09-25

ABSTRACTGlobal markets are making the issue of multiple markets especially evident. In light of this, the present paper proposes a theoretical framework for the study of multiple markets based on combining Michel Callon’s concept of framing with Harrison White’s concept of decoupling. Following a review of the literature on global markets in economic sociology and social studies of markets, the proposed theoretical framework is discussed in detail. The focus is on the processes of creating complex calculative frames, which help reduce uncertainties in the operational environment as well as sociocultural contexts. Through these processes, it is possible to analyse how actors form alliances and maintain global markets. The case of the global market for World Music is presented to illustrate the advantages of this theoretical framework.KEYWORDS: Global marketsmultiple marketscalculative framesdecoupling AcknowledgementsI would like to thank the editors and the anonymous reviewers for their valuable and insightful comments on an earlier draft, and Carla Hammes-Welch for editing the paper. All opinions, omissions, and errors remain my own.Disclosure statementNo potential conflict of interest was reported by the author(s).Notes1 It is important to stress that the calculation of the trade-off between contingency, ambage, and ambiguity is an analytical approach to understand the process of boundary-making in markets. It does not imply that the actors are consciously trading off between these factors in their actions to define, extinguish, and redefine market boundaries.Additional informationNotes on contributorsGlaucia Peres da SilvaGlaucia Peres da Silva is sociologist, specialized in globalization and cross-border processes. Her PhD in economic sociology focused on the formation of global markets, analyzing the case of the world music market. At the University of Tübingen, she is responsible for the development of the Global Awareness Education with focus on the Humanities and Social Sciences. The focus of her work is the inter- and transdisciplinary teaching on globalization, international networking and development of transfer projects.
Yttrium Complexes with Group 13 Heterobenzene‐Type Ligands
2023-09-25

Abstract The yttrium gallabenzene complex [(1‐Me‐3,5‐ t Bu 2 −C 5 H 3 Ga)( μ ‐Me)Y(2,4‐dtbp)] is accessible from Y(GaMe 4 ) 3 and K(2,4‐dtbp) via a tandem salt metathesis/methane elimination (2,4‐dtbp=2,4‐di‐ tert ‐butyl‐pentadienyl). The pentadienyl ligand in [(1‐Me‐3,5‐ t Bu 2 −C 5 H 3 E)( μ ‐Me)Y(2,4‐dtbp)] (E=Al, Ga) is easily displaced by salt metathesis with KC 5 Me 5 and KTp Me,Me (Tp Me,Me =tris(pyrazolyl‐Me 2 ‐3,5)borato) affording [(1‐Me‐3,5‐ t Bu 2 −C 5 H 3 E)( μ ‐Me)Y(Tp Me,Me )] and [(1‐Me‐3,5‐ t Bu 2 −C 5 H 3 E)( μ ‐Me)Y(C 5 Me 5 )]. The yttrium center in [(1‐Me‐3,5‐ t Bu 2 −C 5 H 3 E)( μ ‐Me)Y(2,4‐dtbp)] readily forms adducts with neutral Lewis bases like 4‐DMAP (4‐dimethylaminopyridine), PMe 3 , DMPE (1,2‐bis(dimethylphosphino)ethane), and DME (1,2‐dimethoxyethane). In stark contrast, addition of TMEDA ( N , N , N’ , N’ ‐tetramethylethylenediamine) results in methyl/pentadienyl exchange between aluminum and yttrium resulting in [(1‐(2,4‐dtbp)‐1‐Me‐3,5‐ t Bu 2 −C 5 H 3 Al)Y(Me)(tmeda)]. The bonding features of the newly synthesized complexes are analyzed by single‐crystal X‐ray diffraction (SCXRD) and heteronuclear ( 89 Y, 31 P) NMR spectroscopy.
Bulk-to-boundary propagators with arbitrary total angular momentum J in soft-wall AdS/QCD
2023-09-25

We derive the equations of motion for the bulk-to-boundary propagators of the anti-de Sitter (AdS) boson and fermion fields with arbitrary total angular momentum in a soft-wall AdS/QCD model and solve it analytically. It provides the opportunity to study transition form factors induced by these bulk-to-boundary propagators, both for on-shell and off-shell hadrons. This is a continuation of our study of hadron form factors induced by the bulk-to-boundary propagator with total angular momentum (e.g., electromagnetic form factors of mesons, nucleons, and nucleon resonances).
BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
2023-09-25

Abstract BRI1-ASSOCIATED KINASE 1 (BAK1/SERK3) and its closest homolog BAK1-LIKE 1 (BKK1/SERK4) are leucine-rich repeat receptor kinases (LRR-RKs) belonging to the SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK) family. They act as co-receptors of various other LRR-RKs and participate in multiple signaling events by complexing and transphosphorylating ligand-binding receptors. Initially identified as the brassinosteroid receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1) co-receptor, BAK1 also functions in plant immunity by interacting with pattern recognition receptors. Mutations in BAK1 and BKK1 cause severely stunted growth and cell death, characterized as autoimmune cell death. Several factors play a role in this type of cell death, including RKs and components of effector-triggered immunity (ETI) signaling pathways, glycosylation factors, ER quality control components, nuclear trafficking components, ion channels, and Nod-like receptors (NLRs). The Shan lab has recently discovered a novel RK BAK-TO-LIFE 2 (BTL2) that interacts with BAK1 and triggers cell death in the absence of BAK1 and BKK1. This RK compensates for the loss of BAK1-mediated pattern-triggered immunity (PTI) by activating phytocytokine-mediated immune and cell death responses.
Myasthenia gravis as initial presentation of a pancreatic neuroendocrine tumor: A case report
2023-09-25

Myasthenia gravis (MG) is a heterogeneous autoimmune disease, which is characterized by a postsynaptic neuromuscular transmission defect, with antibodies directly targeting the acetylcholine receptor (AChR) or other structural proteins of the neuromuscular junction. The majority of MG cases are associated with thymic pathologies, including thymoma, thyroiditis, autoimmune diseases or malignant hematologic neoplasia. The present study reported a rare case of AChR-positive and late-onset ocular MG, which rapidly progressed to a generalized myasthenic syndrome as an initial presentation of a pancreatic neuroendocrine neoplasia (pNEN). Following complete surgical resection of the pNEN, the myasthenic syndrome was improved and the anti-AChR antibody titers were reduced. It has been reported that MG is a paraneoplastic syndrome in thymic neoplasms and less common in hematologic malignancies. However, currently, only few cases of MG as initial presentation of a solid tumor, and more particular of a neuroendocrine neoplasm, have been reported in the literature. In conclusion, surveillance for extrathymic solid malignancies in newly diagnosed patients with MG could promote the early diagnosis of associated tumor diseases.
Data set for "Photoelectrochemical Schlenk cell functionalization of multi-junction water-splitting photoelectrodes"
2023-09-25

The data set is organised along the figures of the publication. The '.ers' and '.ert' files are reflection anisotropy spectra and and transients, respectively, in the native format of Laytec's EpiRAS. The '.xy' files are XPS data in the export format of SpecsLab Prodigy. The electrochemistry data is in the '.txt' file format "Zahner Online Display data file version: 2" exported from the Zahner ZenniumPro potentiostat. Currents are absolute currents, For sample areas see the additional file description.
Halide Complexes of 5,6‐Dicyano‐2,1,3‐Benzoselenadiazole with 1 : 4 Stoichiometry: Cooperativity between Chalcogen and Hydrogen Bonding
2023-09-26

Abstract The [M 4 −Hal] − (M=the title compound; Hal=Cl, Br, and I) complexes were isolated in the form of salts of [Et 4 N] + cation and characterized by XRD, NMR, UV‐Vis, DFT, QTAIM, EDD, and EDA. Their stoichiometry is caused by a cooperative interplay of σ‐hole‐driven chalcogen ( ChB ) and hydrogen ( HB ) bondings. In the crystal, [M 4 −Hal] − are connected by the π‐hole‐driven ChB ; overall, each [Hal] − is six‐coordinated. In the ChB , the electrostatic interaction dominates over orbital and dispersion interactions. In UV‐Vis spectra of the M+[Hal] − solutions, ChB ‐typical and [Hal] − ‐dependent charge‐transfer bands are present; they reflect orbital interactions and allow identification of the individual [Hal] − . However, the structural situation in the solutions is not entirely clear. Particularly, the UV‐Vis spectra of the solutions are different from the solid‐state spectra of the [Et 4 N] + [M 4 −Hal] − ; very tentatively, species in the solutions are assigned [M−Hal] − . It is supposed that the formation of the [M 4 −Hal] − proceeds during the crystallization of the [Et 4 N] + [M 4 −Hal] − . Overall, M can be considered as a chromogenic receptor and prototype sensor of [Hal] − . The findings are also useful for crystal engineering and supramolecular chemistry.
Classifying Industrial Sectors from German Textual Data with a Domain Adapted Transformer
2023-09-26

For economics and sociological research, lists of industries and their branches are widely used in research to categorize data and get an overview on different types of industries. However, many different taxonomies and ordering schema exist, due to different research focus but also due to different national scenarios and interests. In this paper, we will focus without loss of generality on regional data from Germany. Manual annotation of textual data is time-consuming and tedious, naturally giving rise to our initial research question, also highly inspired by questions from computational social sciences: How can we automatically categorize textual data, e.g. job advertisements or business Profiles, by industrial sectors We will present an approach towards classification using a pre-trained domain-adapted Transformer model. We find that domain-adapted models generalize better and outperform state of the art non domain-adapted Transformer models on Out-Of-Distribution data. Additionally, we open source two novel data-sets mapping textual data to WZ2008 sections and divisions, enabling further research.
Tracing past extreme floods on an alluvial fan using geophysical surveying
2023-09-26

Summary Sedimentary units in alluvial fans may record gradual transport and deposition during multiple floods or sediment‐laden flows or, conversely, during few catastrophic events. While outcrops are a valuable source of direct information to constrain past geomorphic and hydrologic processes, such exposures are scarce, especially along aggrading rivers or those that have been subject to recent catastrophic sedimentation. In this context, near‐surface geophysical techniques can constrain the dimensions, internal architecture, composition, and petrophysical properties of different sedimentary units. We consider the Grimmbach alluvial fan in the cuesta landscape of southwestern Germany, which was heavily impacted by sediment and wood loads during a flash flood in 2016; published radiocarbon dates indicate that at least three floods similar to the one in 2016 may have occurred since the 17th century. To test whether and to which detail near‐surface geophysics might reveal the sedimentary legacy of these floods, we survey the Grimmbach alluvial fan using detailed topographic data and geophysical imaging based on electromagnetic induction, electrical resistivity tomography (ERT), and ground‐penetrating radar. Our geophysical results indicate former channel courses and two coarse bar deposits up to 3 m below the surface, which are comparable with the more extensive bar deposits of the 2016 flood. From the ERT models, we interpret coarse, up to 5 m thick, gravel lag overlying bedrock at a maximum depth of 10 m. Our geophysical results also highlight patches of finer materials derived from gradual sedimentation and soil development. Overall, our results show that the Grimmbach alluvial fan may have formed and reshaped during catastrophic flows, which likely caused channel avulsions. Our findings point to the need to reconsider flash flood and debris‐flow hazards in similar headwaters and fans of this seemingly quiescent cuesta landscape in southern Germany.
PFΔScreen – An open-source tool for automated PFAS feature prioritization in non-target HRMS data
2023-09-26

Per- and polyfluoroalkyl substances (PFAS) are a huge group of anthropogenic chemicals with unique properties that are used in countless products and applications. Due to the high stability of their C–F bonds, PFAS or their transformation products (TPs) are persistent in the environment, leading to ubiquitous detection in various samples worldwide. Since PFAS are industrial chemicals, the availability of authentic PFAS reference standards is limited, making non-target screening (NTS) approaches based on high-resolution mass spectrometry (HRMS) necessary for a more comprehensive characterization. NTS usually is a time-consuming process, since only a small fraction of the detected chemicals can be identified. Therefore, efficient prioritization of relevant HRMS signals is one of the most crucial steps. We developed PFΔScreen, a Python-based open-source tool with a simple graphical user interface (GUI) to perform efficient feature prioritization by several PFAS specific techniques such as the highly promising MD/C-m/C approach, Kendrick mass defect analysis, diagnostic fragments (MS2), fragment mass differences (MS2) and suspect screening. Feature detection from vendor-independent MS raw data (mzML, data-dependent acquisition) is performed via pyOpenMS (or custom feature lists) with subsequent calculations for prioritization and identification of PFAS in both HPLC- and GC-HRMS data. The PFΔScreen workflow is presented on four PFAS-contaminated agricultural soil samples from south-western Germany. Over 15 classes of PFAS (more than 80 single compounds with several isomers) could be identified, including four novel classes, potentially TPs of the precursors fluorotelomer mercapto alkyl phosphates (FTMAPs). PFΔScreen can be used within the Python environment and is easily automatically installable and executable on Windows. Its source code is freely available on GitHub (https://github.com/JonZwe/PFAScreen).