Effects of Neurexan® on brain responses to deviant stimuli during an auditory oddball task
2017-01-01

Event Abstract Back to Event Effects of Neurexan® on brain responses to deviant stimuli during an auditory oddball task Lena Danyeli1, 2, 3*, Sarah Alizadeh3, Galina Surova2, Hamidreza Jamalabadi3, Myron Schultz4 and Martin Walter2, 3 1 Otto-von-Guericke University Magdeburg, Department of Psychiatry and Psychotherapy, Germany 2 Clinical Affective Neuroimaging Laboratory, Germany 3 Eberhard Karls University Tübingen, Department for Psychiatry and Psychotherapy, Germany 4 Biologische Heilmittel Heel GmbH, Germany Introduction: Neurexan®, a medicinal product sold over the counter (OTC), is composed of four plant and mineral ingredients; passionflower, oats, coffee and zinc valerianate. Neurexan® has been investigated in patients with symptoms related to acute stress, nervousness/restlessness, and insomnia. The previous research suggested an attenuated neuroendocrine stress response in healthy volunteers induced by Neurexan® (Doering et al. 2016). This study further explores the effects of Neurexan® on cognitive performance and attention. It is generally recognized that stress is associated with cognitive impairments. Expecting that Neurexan® reduces the stress level, we hypothesized that the subjects in the placebo group would be more susceptible to distraction compared to treatment group. Material and Methods: In a randomized, placebo-controlled, double-blind, two-period crossover trial, brain responses of 39 healthy, moderate stressed males were measured during an unattended auditory oddball paradigm via 64-channel electroencephalogram (EEG) after intake of Neurexan® and placebo. The paradigm consisted of 80% standard tones and two types of deviant tones (10% frequency deviant; 10% duration deviant), presented in a pseudo-randomized order. The standard tone was composed of eight equally loud sinusoidal tones (fundamental frequency 330 Hz and seven harmonic partials) and had a duration of 100 ms. The deviants were either 40 ms shorter (duration deviant) or 1.25 semitones higher (frequency deviant). Results: Here we present the results about the effect of Neurexan treatment on both mismatch negativity (MMN) and latency of the peaks when assessing EEG responses (ERPs) to deviant tones (frequency and duration deviant) compared to placebo. Discussion: Our findings suggest that Neurexan® also leads to subtle primary processing changes additionally to its postulated top down effects. References Doering, B. K.; Wegner, A.; Hadamitzky, M.; Engler, H.; Rief, W.; Schedlowski, M. (2016): Effects of Neurexan® in an experimental acute stress setting—An explorative double-blind study in healthy volunteers. In: Life sciences 146, S. 139–147. Keywords: Neurexan, auditory odd-ball task, Brain responses, EEG, Stress level Conference: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future, London, United Kingdom, 6 Jul - 7 Jul, 2017. Presentation Type: Poster Topic: Pharmacological / Somatic treatments Citation: Danyeli L, Alizadeh S, Surova G, Jamalabadi H, Schultz M and Walter M (2019). Effects of Neurexan® on brain responses to deviant stimuli during an auditory oddball task. Front. Psychiatry. Conference Abstract: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future. doi: 10.3389/conf.fpsyt.2017.48.00008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 May 2017; Published Online: 25 Jan 2019. * Correspondence: Miss. Lena Danyeli, Otto-von-Guericke University Magdeburg, Department of Psychiatry and Psychotherapy, Magdeburg, Germany, lena.danyeli@gmx.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lena Danyeli Sarah Alizadeh Galina Surova Hamidreza Jamalabadi Myron Schultz Martin Walter Google Lena Danyeli Sarah Alizadeh Galina Surova Hamidreza Jamalabadi Myron Schultz Martin Walter Google Scholar Lena Danyeli Sarah Alizadeh Galina Surova Hamidreza Jamalabadi Myron Schultz Martin Walter PubMed Lena Danyeli Sarah Alizadeh Galina Surova Hamidreza Jamalabadi Myron Schultz Martin Walter Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.