julilili42/papers huggingface dataset:
Recurrence analysis of extreme event like data
2020-10-31

Abstract. The identification of recurrences at various time scales in extreme event-like time series is challenging because of the rare occurrence of events which are separated by large temporal gaps. Most of the existing time series analysis techniques cannot be used to analyse extreme event-like time series in its unaltered form. The study of the system dynamics by reconstruction of the phase space using the standard delay embedding method is not directly applicable to event-like time series as it assumes a Euclidean notion of distance between states in the phase space. The edit distance method is a novel approach that uses the point-process nature of events. We propose a modification of edit distance to analyze the dynamics of extreme event-like time series by incorporating a nonlinear function which takes into account the sparse distribution of extreme events and utilizes the physical significance of their temporal pattern. We apply the modified edit distance method to event-like data generated from point process as well as flood event series constructed from discharge data of the Mississippi River in USA, and compute their recurrence plots. From the recurrence analysis, we are able to quantify the deterministic properties of extreme event-like data. We also show that there is a significant serial dependency in the flood time series by using the random shuffle surrogate method.
Insulin sensitivity predicts cognitive decline in individuals with prediabetes
2020-11-01

Introduction Epidemiological studies indicate an association between type 2 diabetes and cognitive dysfunction that appear to start already in the prediabetic state. Although cross-sectional studies have linked insulin resistance to impaired cognition, the potential predictive value of insulin resistance has not yet been sufficiently studied longitudinally without confounding by overt diabetes (and its pharmacological treatment). Research design and methods We investigated longitudinal data from participants of the ‘Tübinger Evaluation of Risk Factors for Early Detection of Neurodegeneration’ Study. Subjects underwent a neurocognitive assessment battery (CERAD Plus battery; Consortium to Establish a Registry for Alzheimer’s Disease) at baseline and followed every 2 years (median follow-up 4.0 Q1–3: 2.2–4.3 years). Subjects within a pre-diabetic glycated hemoglobin range of 5.6%–6.5% underwent 5-point 75 g oral glucose tolerance tests (OGTTs) with assessment of insulin sensitivity and insulin secretion (n=175). Subjects with newly diagnosed diabetes mellitus or with major depressivity (Beck Depression Inventory &gt;20) were excluded (n=15). Data were analyzed by mixed models using sex, age and glycemic trait as fixed effects. Subject and time since first measurement were used as random effects. Results Insulin sensitivity was positively associated with the CERAD sum score (higher is better) in a time-dependent manner (p=0.0057). This result is mainly driven by a steeper decrease in the memory domain associated with lower insulin sensitivity (p=0.029). The interaction between age and insulin sensitivity was independent of glycemia (p=0.02). There was also no association between insulin secretion and cognition. Conclusions Insulin resistance rather than sole elevation of blood glucose predicts cognitive decline, specifically in the memory domain, in persons with prediabetes. Treatments of diabetes that improve insulin sensitivity might therefore have the potential to postpone or even prevent cognitive decline in patients with diabetes.
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial
2020-11-01

Background Peptide-based vaccination is a rational option for immunotherapy of prostate cancer. In this first-in-man phase I/II study, we assessed the safety, tolerability and immunological impact of a synthetic long peptide vaccine targeting Ras homolog gene family member C (RhoC) in patients with prostate cancer. RhoC is a small GTPase overexpressed in advanced solid cancers, metastases and cancer stem cells. Methods Twenty-two patients who had previously undergone radical prostatectomy received subcutaneous injections of 0.1 mg of a single RhoC-derived 20mer peptide emulsified in Montanide ISA-51 every 2 weeks for the first six times, then five times every 4 weeks for a total treatment time of 30 weeks. The drug safety and vaccine-specific immune responses were assessed during treatment and thereafter within a 13-month follow-up period. Serum level of prostate-specific antigen was measured up to 26 months postvaccination. Results Most patients (18 of 21 evaluable) developed a strong CD4 T cell response against the vaccine, which lasted at least 10 months following the last vaccination. Three promiscuouslypresented HLA-class II epitopes were identified. Vaccine-specific CD4 T cells were polyfunctional and effector memory T cells that stably expressed PD-1 (CD279) and OX-40 (CD134), but not LAG-3 (CD223). One CD8 T cell response was detected in addition. The vaccine was well tolerated and no treatment-related adverse events of grade ≥3 were observed. Conclusion Targeting of RhoC induced a potent and long-lasting T cell immunity in the majority of the patients. The study demonstrates an excellent safety and tolerability profile. Vaccination against RhoC could potentially delay or prevent tumor recurrence and metastasis formation. Trial registration number NCT03199872 .
Dietary Intakes of Zinc, Copper, Magnesium, Calcium, Phosphorus, and Sodium by the General Adult Population Aged 20–50 Years in Shiraz, Iran: A Total Diet Study Approach
2020-11-01

In the present total diet study, the dietary intake of zinc (Zn), copper (Cu), magnesium (Mg), calcium (Ca), phosphorus (P), and sodium (Na) by healthy adults in Shiraz, Iran, was estimated from the foods as consumed. A total of 580 individual food items were collected, prepared, and pooled into 129 composite samples. The metal concentration was then evaluated using inductively coupled plasma–optical emission spectrometry. The mean intakes of Zn (12.92 mg/d), Cu (3.80 mg/d), and Mg (412.68 mg/d) exceeded the estimated average requirements (EARs), but they were well below the upper limits. A high prevalence of inadequate intake was observed for Ca (91.6%) and P (89.7%), which was mainly due to nutritionally imbalanced diets. Sodium intake for average and high consumers (97.5th percentile) was 123.6% and 237.8% of the tolerable upper intake level of 2300 mg/d, respectively, with 70% of the participants having intakes higher than this threshold value. Nutrition education, nutritional rehabilitation, Ca supplementation, food fortification, mandatory reduction of salt content in processed foods, and discretionary salt use (in home cooking or at the table) are among the possible strategies that can be adopted to combat the health problems.
Precipitation Characteristics and Moisture Source Regions on Mt. Everest in the Khumbu, Nepal
2020-11-01

Precipitation is critical to the water towers of the Hindu Kush-Himalaya-Karakoram region, exerting an important control on glacier mass balance and the water resources for 1.65 billion people. Given that hydroclimatic extremes and water stress have emerged as key hazards in the context of climate change, Nepal's Khumbu region overlaps key vulnerabilities. Here, we investigate the region's precipitation characteristics and moisture sources through analysis of data from a new high-altitude network of automatic weather stations, which allows for a more complete understanding of the climatological precipitation data that are critical information for local communities in the Khumbu region, visitors, and downstream populations. Our findings demonstrate that the northern Bay of Bengal is potentially an important moisture source during the monsoon period (June to August) and that westerly trajectories over land predominate for precipitation events during the post-monsoon, winter, and pre-monsoon seasons.
On the validity of the CNI model of moral decision-making: Reply to Baron and Goodwin (2020)
2020-11-01

Abstract The CNI model of moral decision-making is a formal model that quantifies (1) sensitivity to consequences, (2) sensitivity to moral norms, and (3) general preference for inaction versus action in responses to moral dilemmas. Based on a critique of the CNI model’s conceptual assumptions, properties of the moral dilemmas for research using the CNI model, and the robustness of findings obtained with the CNI model against changes in model specifications, Baron and Goodwin (2020) dismissed the CNI model as a valid approach to study moral dilemma judgments. Here, we respond to their critique, showing that Baron and Goodwin’s dismissal of the CNI model is based on: (1) misunderstandings of key aspects of the model; (2) a conceptually problematic conflation of behavioral effects and explanatory mental constructs; (3) arguments that are inconsistent with empirical evidence; and (4) reanalyses that supposedly show inconsistent findings resulting from changes in model specifications, although the reported reanalyses did not actually use the CNI model and proper analyses with the CNI model yield consistent findings across model specifications. Although Baron and Goodwin’s critique reveals a need for greater precision in the description of the three model parameters and for greater attention to properties of individual dilemmas, the available evidence indicates that the CNI model is a valid, robust, and empirically sound approach to gaining deeper insights into the determinants of moral dilemma judgments, overcoming major limitations of the traditional approach that pits moral norms against consequences for the greater good (e.g., trolley dilemma).
<p>Menopausal Symptoms and Associated Social and Environmental Factors in Midlife Chinese Women</p>
2020-11-01

All symptoms, except cognitive and urogenital symptoms, worsened age-dependently up to 60 years but improved beyond this age; most were also associated with menopause. For the first time in a large study population, it was observed that soy-rich diet is protective but only with daily consumption. Exercising can protect against some of the symptoms. HRT decreased all symptoms, but regular use is necessary. Women with higher education reported less symptoms, but after adjustments no other relationships were observed (ChiCTR2000035047).
Prevention of stroke in patients with chronic coronary syndromes or peripheral arterial disease
2020-11-01

Abstract Stroke is a common and devastating condition caused by atherothrombosis, thromboembolism, or haemorrhage. Patients with chronic coronary syndromes (CCS) or peripheral artery disease (PAD) are at increased risk of stroke because of shared pathophysiological mechanisms and risk-factor profiles. A range of pharmacological and non-pharmacological strategies can help to reduce stroke risk in these groups. Antithrombotic therapy reduces the risk of major adverse cardiovascular events, including ischaemic stroke, but increases the incidence of haemorrhagic stroke. Nevertheless, the net clinical benefits mean antithrombotic therapy is recommended in those with CCS or symptomatic PAD. Whilst single antiplatelet therapy is recommended as chronic treatment, dual antiplatelet therapy should be considered for those with CCS with prior myocardial infarction at high ischaemic but low bleeding risk. Similarly, dual antithrombotic therapy with aspirin and very-low-dose rivaroxaban is an alternative in CCS, as well as in symptomatic PAD. Full-dose anticoagulation should always be considered in those with CCS/PAD and atrial fibrillation. Unless ischaemic risk is particularly high, antiplatelet therapy should not generally be added to full-dose anticoagulation. Optimization of blood pressure, low-density lipoprotein levels, glycaemic control, and lifestyle characteristics may also reduce stroke risk. Overall, a multifaceted approach is essential to best prevent stroke in patients with CCS/PAD.
Adjusting working conditions and evaluating the risk of infection during the COVID-19 pandemic in different workplace settings in Germany: a study protocol for an explorative modular mixed methods approach
2020-11-01

Introduction Currently, many countries, affected by the COVID-19 pandemic, discuss how the ‘lockdown-restrictions’ could be lifted to restart the economy and public life after the first wave of the COVID-19 disease has subsided. This study protocol describes an approach designed to provide an in-depth understanding of how companies and their employees in Germany deal with their working conditions during the COVID-19 pandemic. We are also interested in how and why the risk of infection with SARS-CoV-2 could vary across different professional activities, company sites and regions with different epidemiological activity or infection control measures in Germany. We expect the results of this study to contribute to the development of working conditions protecting the health of employees during and beyond the COVID-19 pandemic. Methods and analysis An explorative multimodal mixed methods approach will be applied. Module 1 comprises a document analysis of prevailing federal and regional laws and regulations at the respective location of the participating company. Module 2 includes qualitative interviews with key actors at different companies. Module 3 is a repeated standardised employee survey designed to capture potential changes in the participants’ experiences and attitudes towards working conditions, occupational safety regulations/measures, and infection control measures during the COVID-19 pandemic. Module 4 comprises SARS-CoV-2 seroprevalence testing. This is carried out by the medical service of the participating company sites as a voluntary offer for employees. Qualitative data will be analysed through document and content analysis. The complexity of the quantitative analysis depends on the response rates of modules 3 and 4. Ethics and dissemination The approval of the study design was received in June 2020 from the responsible local ethical committee of the Medical Faculty, University of Tübingen and University Hospital Tübingen (No. 423/2020BO). The results will be presented at national and international conferences and published in peer-reviewed journals.
Update Breast Cancer 2020 Part 4 – Advanced Breast Cancer
2020-11-01

Abstract Substances with good effectiveness that intervene in specific signalling pathways have been used increasingly in recent years in the treatment of patients with advanced breast cancer, and new therapies and approaches have now been added, which actually relate to quite specific changes, such as the treatment of patients with HR+/HER2 tumours with a PIK3CA mutation. The treatment of patients with a BRCA1 or BRCA2 mutation has also been improved by the introduction of PARP inhibitors. Attempts are now being made increasingly to extend treatment indications based on molecular patterns, to identify other patients who could benefit from a treatment and to integrate the newly established treatment methods in existing therapy sequences. This review articles summarises the latest information in this connection.
Update Breast Cancer 2020 Part 3 – Early Breast Cancer
2020-11-01

Abstract The treatment of patients with early breast cancer has always been characterised by escalation by new therapies and de-escalation through identification of better treatment regimens or introduction of better tools to estimate prognosis. Efforts in some of these areas in the last few years have led to solid data. The results of the large studies of de-escalation through use of multi-gene tests are available, as are the results of some studies that investigated the new anti-HER2 substances T-DM1 and pertuzumab in the early treatment situation. Several large-scale studies examining the role of CDK4/6 inhibitors will soon be concluded so innovations can be anticipated in this area also. This review article will summarise and classify the results of the latest publications.
Sustainable district energy integrating biomass peaking with geothermal baseload heating: A case study of decarbonizing Cornell's energy system
2020-11-01

Many governments and institutions are advocating for higher renewable energy deployment to lower their carbon footprint and mitigate the effects of climate change. Cornell University instituted the “climate action plan” to achieve carbon neutrality, of which geothermal heat extracted from deep rocks (Earth source heat) is a critical component. This paper proposes coupling baseload geothermal heating with energy from waste biomass from Cornell's dairy farms to meet the campus' peak heating demand. The envisioned biomass peaking system, consisting of a hybrid anaerobic digestion/hydrothermal liquefaction/biomethanation process, produces renewable natural gas (RNG) for injection and storage into the natural gas (NG) distribution grid and uses NG withdrawals at times of peak heating demand. We show that 97% of the total annual peak heating demand (9661 MW h) can be met using continuous RNG production using manure from Cornell's 600 dairy cows, which provides 910 × 106 l of RNG/year. The overall RNG system requires 32/GJ (minimum RNG selling price) and a net present value of 47/MJ) and assuming wholesale utilities costs (NG withdrawals and electric imports). Selling RNG at the New York commercial NG price ( 70/GJ) in excess of the RNG selling price, highlighting the importance of carbon credits for financial profitability.
Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans
2020-11-01

Abstract Background Dusp8 is the first GWAS‐identified gene that is predominantly expressed in the brain and has previously been linked with the development of diabetes type 2 in humans. In this study, we unravel how Dusp8 is involved in the regulation of sucrose reward behavior. Methods Female, chow‐fed global Dusp8 WT and KO mice were tested in an observer‐independent IntelliCage setup for self‐administrative sucrose consumption and preference followed by a progressive ratio task with restricted sucrose access to monitor seeking and motivation behavior. Sixty‐three human carriers of the major C and minor T allele of DUSP8 SNP rs2334499 were tested for their perception of food cues by collecting a rating score for sweet versus savory high caloric food. Results Dusp8 KO mice showed a comparable preference for sucrose, but consumed more sucrose compared to WT mice. In a progressive ratio task, Dusp8 KO females switched to a “trial and error” strategy to find sucrose while control Dusp8 WT mice kept their previously established seeking pattern. Nonetheless, the overall motivation to consume sucrose, and the levels of dopaminergic neurons in the brain areas NAcc and VTA were comparable between genotypes. Diabetes‐risk allele carriers of DUSP8 SNP rs2334499 preferred sweet high caloric food compared to the major allele carriers, rating scores for savory food remained comparable between groups. Conclusion Our data suggest a novel role for Dusp8 in the perception of sweet high caloric food as well as in the control of sucrose consumption and foraging in mice and humans.
Combining Ion Chromatography and Total Reflection X-ray Fluorescence for Detection of Major, Minor and Trace Elements in Quartz-Hosted Fluid Inclusions
2020-11-01

The crush-leach technique is a frequently used method to determine the bulk composition of fluid inclusions trapped in a range of geological samples. We present a modified crush-leach technique combining ion chromatography (IC) and total reflection X-ray fluorescence spectroscopy (TXRF) which allows to determine a range of major, minor and trace elements out of one leachate. To date, trace element detection by means of TXRF is barely used in geosciences, although it combines the advantages of low to very low detection limits (μg/L to ng/L range), small sample amount needed (μL-range) and a fast and inexpensive analytical procedure. Previously described problems of adsorption of polyvalent cations at sample surfaces have been overcome by using acidified water as a leachate. Instead, it has been demonstrated that, for example, the syringe filter type used for IC measurements influences contamination and/or adsorption for a number of elements. The proposed method combination was evaluated for accuracy, reproducibility and system blanks and subsequently applied to quartz samples from hydrothermal vein deposits of the Schwarzwald ore district, SW Germany.
Does Self-Associating a Geometric Shape Immediately Cause Attentional Prioritization?
2020-11-01

Abstract. In many cognitive tasks, stimuli associated with one’s self elicit faster responses than stimuli associated with others. This is true for familiar self-representations (e.g., one’s own name), for new self-associated stimuli, and for combinations of both. The current research disentangles the potential of self- versus stranger-representations for familiar, new, and paired (familiar + new) stimuli to guide attention. In Study 1 ( N = 34), responses to familiar and new self- versus other representations were tested in a dot-probe task with a short stimulus-onset asynchrony (SOA; 100 ms). Study 2 ( N = 31) and Study 3 ( N = 35) use a long SOA (1,000 ms) to test whether the findings are mirrored in inhibition of return (IOR). We observe significant performance differences for targets following self- versus stranger-associated stimuli (i.e., a cuing effect or IOR depending on the SOA length), yet only when familiar representations are present. This indicates that, under conditions of attentional competition between self- and stranger-representations, familiar self-representations impact the distribution of attention while new self-representations alone do not.
Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients
2020-11-01

Abstract Background As cancer cachexia (CC) is associated with cancer progression, early identification would be beneficial. The aim of this study was to establish a workflow for automated MRI-based segmentation of visceral (VAT) and subcutaneous adipose tissue (SCAT) and lean tissue water (LTW) in a B16 melanoma animal model, monitor diseases progression and transfer the protocol to human melanoma patients for therapy assessment. Methods For in vivo monitoring of CC B16 melanoma-bearing and healthy mice underwent longitudinal three-point DIXON MRI (days 3, 12, 17 after subcutaneous tumor inoculation). In a prospective clinical study, 18 metastatic melanoma patients underwent MRI before, 2 and 12 weeks after onset of checkpoint inhibitor therapy (CIT; n = 16). We employed an in-house MATLAB script for automated whole-body segmentation for detection of VAT, SCAT and LTW. Results B16 mice exhibited a CC phenotype and developed a reduced VAT volume compared to baseline (B16 − 249.8 μl, − 25%; controls + 85.3 μl, + 10%, p = 0.003) and to healthy controls. LTW was increased in controls compared to melanoma mice. Five melanoma patients responded to CIT, 7 progressed, and 6 displayed a mixed response. Responding patients exhibited a very limited variability in VAT and SCAT in contrast to others. Interestingly, the LTW was decreased in CIT responding patients (− 3.02% ± 2.67%; p = 0.0034) but increased in patients with progressive disease (+ 1.97% ± 2.19%) and mixed response (+ 4.59% ± 3.71%). Conclusion MRI-based segmentation of fat and water contents adds essential additional information for monitoring the development of CC in mice and metastatic melanoma patients during CIT or other treatment approaches.