julilili42/papers huggingface dataset:
The Nomological Net of Knowledge, Self-Reported Knowledge, and Overclaiming in Children
2022-11-28

Research on self-reported knowledge and overclaiming in children is sparse. With the current study, we aim to close this gap by developing an overclaiming questionnaire measuring self-reported knowledge and overclaiming that is tailored to children. Moreover, we examine the nomological net of self-reported knowledge and overclaiming in childhood discussing three perspectives: Overclaiming as (a) a result of deliberate self-enhancement tendencies, (b) a proxy for declarative knowledge, and (c) an indicator of creative engagement. We juxtaposed overclaiming, as indicated by claiming familiarity with non-existent terms, and self-reported knowledge with fluid and crystallized intelligence, creativity, and personality traits in a sample of 897 children attending third grade. The results of several latent variable analyses were similar to findings known from adult samples: We found no strong evidence for any of the competing perspectives on overclaiming. Just like in adults, individual differences in self-reported knowledge were strongly inflated by overclaiming, and only weakly related to declarative knowledge.
Multilayer Langmuir Film of Monodisperse Au Nanoclusters: Unusual Growth via Bilayers
2022-11-28

The assembly of nanomaterials into thin films is an important area in the nanofabrication of novel devices. The monodispersity of nanoparticles plays an essential role in the resulting quality of the assembled mono- and multilayers. Larger polydispersity leads to smaller lateral correlation lengths and smaller domains of aligned nanoparticles, thus resulting in more point and line defects. Perfectly monodisperse nanoparticles should therefore minimize the number of defects in the assembled films. Despite tremendous progress in reducing the polydispersity of nanoparticles, there has been limited research on the assembly of thin films out of perfectly monodisperse nanoclusters. Here, we show a formation of Langmuir films using perfectly monodisperse gold nanoclusters with composition Au<sub>32</sub>(<sup><i>n</i></sup>Bu<sub>3</sub>P)<sub>12</sub>Cl<sub>8</sub> exhibiting a diameter of 1.8 nm. Using both <i>in situ</i> and <i>ex situ</i> small-angle X-ray scattering, we show that the monolayer formed on a Langmuir-Blodgett trough exhibits long-range order. Moreover, after compressing the monolayer, we found that the stress accumulated prior to the monolayer collapse triggers a transition to a short-range order not previously reported. If such monolayer is compressed further, the second layer is not formed as in the case of standard nanoparticles. Instead, a growth of islands by an odd number of layers is observed, leading to a thin film with a structure consisting of two different orientations of the hexagonal lattice. Such anomalous behavior may have implications for the possibilities of thin-film formation.
The geologically oldest specimen of Pterodactylus: a new exquisitely preserved skeleton from the Upper Jurassic (Kimmeridgian) Plattenkalk deposits of Painten (Bavaria, Germany)
2022-11-28

Pterodactylus from the uppermost Jurassic of southern Germany represents one of the most iconic pterosaurs, due to its status of being the first member of the Pterosauria to have been described and named. During the early phase of pterosaur research, Pterodactylus was a wastebasket taxon containing dozens of sometimes distantly related assigned species. Decades later, a comprehensive revision of the genus significantly reduced the number of species. To date, only one species remains in the genus, Pterodactylus antiquus , although the referral of several specimens to this taxon and the taxonomic relationships of them is still debated. Thus far, the genus has been only reported from the Upper Jurassic Plattenkalk deposits of Bavaria, and all of these occurrences are Tithonian in age. Here we describe the first record of Pterodactylus from the Torleite Formation near Painten (Bavaria), which represents the first occurrence of the genus from the Kimmeridgian. The specimen is a complete, articulated and exquisitely preserved skeleton of a small-sized individual. Aside from its old geological age, it is a typical representative of the genus, greatly resembling other specimens from younger strata. Certain characters, such as the overall size, skull length, relative orbit size, and phalangeal formula indicate that the specimen from Painten represents a juvenile to young subadult individual, an ontogenetic stage rarely found among Pterodactylus specimens. The find significantly expands the temporal range of the taxon and represents one of the best-preserved specimens of the genus reported so far.
Characterization of Shear Stress Mediated Platelet Dysfunction: Data from an Ex Vivo Model for Extracorporeal Circulation and a Prospective Clinical Study
2022-11-28

Extracorporeal circulation (ECC) is frequently used in intensive care patients with impaired lung or cardiac function. Despite being a life-saving therapeutic option, ECC is associated with increased risk for both bleeding and thrombosis. The management of bleeding and thromboembolic events in ECC patients is still challenging partly due to the lack of information on the pathophysiological changes in hemostasis and platelet function during the procedure. Using a combination of an ex vivo model for shear stress and a sensitive and easy-to-use laboratory method, we analyzed platelet responsiveness during ECC. After shear stress simulation in an ex vivo closed-loop ECC model, we found a significantly decreased response of α-granules after activation with adenosine diphosphate and thrombin receptor activating peptide (TRAP-6) and CD63 expression after activation with TRAP-6. Mepacrine uptake was also significantly reduced in the ex vivo shear stress model. In the same line, platelets from patients under ECC with venovenous systems and venoarterial systems showed impaired CD62P degranulation after stimulation with ADP and TRAP-6 compared with healthy control on day 1, 6, and 10 after implantation of ECC. However, no correlation between platelet degranulation and the occurrence of bleeding or thromboembolic events was observed. The used whole blood flow cytometry with immediate fixation after drawing introduces a sensitive and easy-to-use method to determine platelet activation status and our data confirm that increased shear stress conditions under ECC can cause impaired degranulation of platelet.
Playing with temptation: Stopping abilities to chocolate are superior, but also more extensive
2022-11-28

Cue-specific inhibitory control is assumed to support balanced food intake, but previous studies with established measures showed inconsistent results. We developed a novel kinematic stop task in virtual reality (VR) and report results from trajectory recordings. The primary objective of this explorative study was to assess the interrelationships between validated measures of food-related inhibitory control and novel measures from the VR task. We hypothesized that healthy female participants show worse inhibitory control when grasping attractive virtual chocolate, compared to non-edible color-and-shape matched objects. We further aimed to quantify the construct validity of kinematic measures (e.g., reaching extent / spatial displacement, movement time after stop-signal, velocity) with established measures of inhibitory control in a keyboard-based adaptive stop-signal task (SST). In total, 79 females with varying levels of chocolate craving participated in an experimental study consisting of self-report questionnaires, subjective chocolate craving, the conventional SST and the kinematic task in VR. Results showed superior stopping ability to chocolate in both tasks. In VR, participants successfully interrupted an initiated approach trajectory but terminated slightly closer to chocolate targets. Stop-signal delay (SSD) was adapted relative to movement onset and appeared later in chocolate trials, during which participants still stopped faster, as was also confirmed by shorter stop-signal reaction time (SSRT) in the conventional task. Yet, SSRT did not correlate with stopping in VR. Moreover, SSRT was related to depressive symptoms whereas measures from VR were related to chocolate craving and subjective hunger. Thus, VR stopping can provide deeper insights into healthy weight individuals’ capacity to inhibit cue-specific approach behavior towards appetitive stimuli in simulated interactions. Furthermore, the results support a multi-faceted view of food-specific inhibitory control and behavioral impulsivity.
Lazy Queue Layouts of Posets
2022-11-28

Abstract We investigate the queue number of posets in terms of their width, that is, the maximum number of pairwise incomparable elements. A long-standing conjecture of Heath and Pemmaraju asserts that every poset of width w has queue number at most w . The conjecture has been confirmed for posets of width <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>w</mml:mi> <mml:mo>=</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> </mml:math> via so-called lazy linear extension. We extend and thoroughly analyze lazy linear extensions for posets of width <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>w</mml:mi> <mml:mo>&gt;</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> </mml:math> . Our analysis implies an upper bound of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>w</mml:mi> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:mo>+</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:math> on the queue number of width- w posets, which is tight for the strategy and yields an improvement over the previously best-known bound. Further, we provide an example of a poset that requires at least <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>w</mml:mi> <mml:mo>+</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:math> queues in every linear extension, thereby disproving the conjecture for posets of width <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>w</mml:mi> <mml:mo>&gt;</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> </mml:math> .
Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19
2022-11-28

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chemical phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 Mpro. Several compounds were discovered to inhibit the Mpro at low micromolar concentrations. It was possible to crystallize robinetin together with SARS-CoV-2 Mpro, and the X-ray structure revealed covalent interaction with the protease's catalytic Cys145 site. Selected potent molecules also exhibited antiviral properties without cytotoxicity. Some of these powerful inhibitors might be utilized as lead compounds for COVID-19 research.
Modified dipole-dipole interactions in the presence of a nanophotonic waveguide
2022-11-28

When an emitter ensemble interacts with the electromagnetic field, dipole-dipole interactions are induced between the emitters. The magnitude and shape of these interactions are fully determined by the specific form of the electromagnetic field modes. If the emitters are placed in the vicinity of a nanophotonic waveguide, such as a cylindrical nanofiber, the complex functional form of these modes makes the analytical evaluation of the dipole-dipole interaction cumbersome and numerically costly. In this work, we provide a full detailed description of how to successfully calculate these interactions, outlining a method that can be easily extended to other environments and boundary conditions. Such exact evaluation is of importance as, due to the collective character of the interactions and dissipation in this kind of systems, any small modification of the interactions may lead to dramatic changes in experimental observables, particularly as the number of emitters increases. We illustrate this by calculating the transmission signal of the light guided by a cylindrical nanofiber in the presence of a nearby chain of emitters.
A formal approach to Menger's theorem
2022-11-28

Menger's graph theorem equates the minimum size of a separating set for non-adjacent vertices a and b with the maximum number of disjoint paths between a and b. By capturing separating sets as models of an entailment relation, we take a formal approach to Menger's result. Upon showing that inconsistency is characterised by the existence of suficiently many disjoint paths, we recover Menger's theorem by way of completeness.
Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes
2022-11-29

Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. This work provides a comparative summary of common barrier membranes used in GBR, focusing on recent advances in collagen membranes and their biological mechanisms. In conclusion, the review article highlights the biological and regenerative properties of currently available barrier membranes with a particular focus on bioresorbable collagen-based materials. In addition, the advantages and disadvantages of these biomaterials are highlighted, and possible improvements for future material developments are summarized.
Cholesterol Stationary Phase in the Separation and Identification of siRNA Impurities by Two-Dimensional Liquid Chromatography-Mass Spectrometry
2022-11-29

The aim of this research was to develop a simple and efficient ion-pair reagent-free chromatographic method for the separation and qualitative determination of oligonucleotide impurities, exemplified by synthesis of raw products of the two single strands of patisiran siRNA. The stationary phases with mixed hydrophobic/hydrophilic properties (cholesterol and alkylamide) were firstly used for this purpose with reversed-phased high-performance liquid chromatography. Several different chromatographic parameters were tested for their impact on impurities separation: type, concentration, pH of salt, as well as organic solvent type in the mobile phase. The pH was the most influential factor on the separation and signal intensities in mass spectrometry detection. Finally, the optimized method included the application of cholesterol stationary phase, with mobile phase containing 20 mM ammonium formate (pH 6.5) and methanol. It allowed good separation and the identification of most impurities within 25 min. Since not all closely related impurities could be fully resolved from the main peak in this oligonucleotide impurity profiling, two-dimensional liquid chromatography was used for peak purity determination of the target oligonucleotides. The Ethylene Bridged Hybrid (BEH) Amide column in hydrophilic interaction liquid chromatography was applied in the second dimension, allowing additional separation of three closely related impurities.
Monodisperse Porous Silica/Polymer Nanocomposite Microspheres with Tunable Silica Loading, Morphology and Porosity
2022-11-29

Hybrid organic/inorganic nanocomposites combine the distinct properties of the organic polymer and the inorganic filler, resulting in overall improved system properties. Monodisperse porous hybrid beads consisting of tetraethylene pentamine functionalized poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles and silica nanoparticles (SNPs) were synthesized under Stoeber sol-gel process conditions. A wide range of hybrid organic/silica nanocomposite materials with different material properties was generated. The effects of n(H2O)/n(TEOS) and c(NH3) on the hybrid bead properties particle size, SiO2 content, median pore size, specific surface area, pore volume and size of the SNPs were studied. Quantitative models with a high robustness and predictive power were established using a statistical and systematic approach based on response surface methodology. It was shown that the material properties depend in a complex way on the process factor settings and exhibit non-linear behaviors as well as partly synergistic interactions between the process factors. Thus, the silica content, median pore size, specific surface area, pore volume and size of the SNPs are non-linearly dependent on the water-to-precursor ratio. This is attributed to the effect of the water-to-precursor ratio on the hydrolysis and condensation rates of TEOS. A possible mechanism of SNP incorporation into the porous polymer network is discussed.
Optically pumped magnetometers detect altered maximal muscle activity in neuromuscular disease
2022-11-29

Optically pumped magnetometers (OPM) are quantum sensors that enable the contactless, non-invasive measurement of biomagnetic muscle signals, i.e., magnetomyography (MMG). Due to the contactless recording, OPM-MMG might be preferable to standard electromyography (EMG) for patients with neuromuscular diseases, particularly when repetitive recordings for diagnostic and therapeutic monitoring are mandatory. OPM-MMG studies have focused on recording physiological muscle activity in healthy individuals, whereas research on neuromuscular patients with pathological altered muscle activity is non-existent. Here, we report a proof-of-principle study on the application of OPM-MMG in patients with neuromuscular diseases. Specifically, we compare the muscular activity during maximal isometric contraction of the left rectus femoris muscle in three neuromuscular patients with severe (Transthyretin Amyloidosis in combination with Pompe’s disease), mild (Charcot-Marie-Tooth disease, type 2), and without neurogenic, but myogenic, damage (Myotonia Congenita). Seven healthy young participants served as the control group. As expected, and confirmed by using simultaneous surface electromyography (sEMG), a time-series analysis revealed a dispersed interference pattern during maximal contraction with high amplitudes. Furthermore, both patients with neurogenic damage (ATTR and CMT2) showed a reduced variability of the MMG signal, quantified as the signal standard deviation of the main component of the frequency spectrum, highlighting the reduced possibility of motor unit recruitment due to the loss of motor neurons. Our results show that recording pathologically altered voluntary muscle activity with OPM-MMG is possible, paving the way for the potential use of OPM-MMG in larger studies to explore the potential benefits in clinical neurophysiology.
Bread and Plots: Conspiracy Theories and the Rhetorical Style of Political Influencer Communities on YouTube
2022-11-29

Based on the assumption that social media encourages a populist style of politics in online communities and the proposition that populism and conspiracy theories tend to co-occur, this article investigates whether this holds true for YouTube influencers, particularly on the less investigated left-wing spectrum. The article provides qualitative case studies of four different groups of political content creators on YouTube whose content makes use of or analyzes popular culture. The article concludes that a populist style plays a far less central role in left-wing communities on YouTube than on other platforms or within right-wing communities.
Does the Gamma-Ray Binary LS I + 61°303 Harbor a Magnetar?
2022-11-29

Abstract The high-mass X-ray binary LS I + 61°303 is also cataloged as a gamma-ray binary as a result of frequent outbursts at TeV photon energies. The system has released two soft-gamma flares in the past, suggesting a magnetar interpretation for the compact primary. This inference has recently gained significant traction following the discovery of transient radio pulses, detected in some orbital phases from the system, as the measured rotation and tentative spin-down rates imply a polar magnetic field strength of B p ≳ 10 14 G if the star is decelerating via magnetic dipole braking. In this paper, we scrutinize magnetic field estimates for the primary in LS I + 61°303 by analyzing the compatibility of available data with the system’s accretion dynamics, spin evolution, age limits, gamma-ray emissions, and radio pulsar activation. We find that the neutron star’s age and spin evolution are theoretically difficult to reconcile unless a strong propeller torque is in operation. This torque could be responsible for the bulk of even the maximum allowed spin-down, potentially weakening the inferred magnetic field by more than an order of magnitude.
The orbitotemporal region and the mandibular joint in the skull of shrews (Soricidae, Mammalia)
2022-11-29

Modern phylogenetics place the Soricidae (shrews) into the order Lipotyphla, which belongs to the relatively new superorder clade Laurasiatheria. Their most derived skull feature is the unusual position and shape of the jaw articulation: Whereas in all other mammals the glenoid region of the squamosum is more or less tightly attached to the otic capsule or petrosal, respectively, in the soricids it is attached to the nasal capsule. This new position of the jaw articulation becomes possible by the posterior extension of the nasal capsule and the rostral shift of the glenoid fossa. By the study of dated postnatal ontogenetic stages of Crocidura russula and Sorex araneus , we show that the glenoid part of the squamosal becomes fixed to the nasal capsule by the ossified alae orbitalis and temporalis. The ala orbitalis is displaced laterally by the expanded cupula nasi posterior; this posterior expansion is well documented by the lamina terminalis, which incorporates parts of the palatinum and alisphenoid. Both alae consist largely of ‘Zuwachsknochen’ (‘appositional bone’) and are then named orbitosphenoid and alisphenoid. By the forward move of the pars glenoidea and of the alisphenoid, the foramen lacerum medium (‘fenestra piriformis’) also expands rostrally. Functionally, the forward shift of the jaw joint helps to keep the incisal biting force high. Biomechanically the jaws can be considered as a tweezer, and the rostral position of the jaw joints makes the interorbital pillar and the shell-like walls of the facial skull a lever for the highly specialized incisal dentition.