Very Happy with the new Gel-Kayano 22's.  Like the 21's, these are very comfortably cushioned at the heel and fore foot.  The toe-box is snug and the heel counter provides great support.  I am a mid-foot runner and these allow and guide you to stay in line and I don't notice the high 12 mm toe drop, it actually feels lower that that, which is a good thing for me.  At 10.9 ounces the shoe feels light and great for my tempo runs.  I'm training for a marathon in November '15 and I'm happy these came out for me to train in and use for the race.  I've already logged 100+ miles on these Kayano 22's and so far it's been very durable.  I've also ran in the rain in them and they have pretty good traction.  I'm definitely going to buy 2 or more pairs as I love these shoes!  Everything I expected in the shoes from Asics!