SO bummed!! My last 4 pairs of running sneakers were all Asics - 2 pairs of the GT 1000's and 2 pairs of the GT 2000's, all of which I wore straight into the ground. They were terrific for an overpronator who walks like a damn pigeon (i.e. me!). This time, I wanted to try something new and read lots of amazing reviews about the Kayano 21s, including a mention that they made the toe box bigger from the last model. I fell in love with the turquoise/pink/white color scheme so I snagged a pair... although they are amazingly comfortable from the get-go and look superb, the toe box is in no way, shape or form 'bigger'. I was a size 8 in the GT 1000s & 2000s - with the Kayano 21s, the left shoe fits perfect, but my right big toe keeps hitting the front of the sneaker. NOT comfortable! Though they are not causing any real pain, I could not stop focusing on my right toe hitting the front of the sneaker. A size 8.5 will be too big for my left foot, so I guess I am going back to the GT 2000s :( Same situation happened when I tried to buy a pair of the Gel Nimbus sneakers back in the spring, so be forewarned!!