The Implicit Genome
"Maintains an excitement that typically is only found in texts for a lay audience"--Elizabeth A.D. Hammock, Postdoctoral Research Fellow, Vanderbilt University"The Implicit Genomeexplains why the greatest challenge of today's genomics is to annotate the biological functions of DNA sequences. The language of genomes is written in a simple alphabet of As, Ts, Gs, and Cs, but it is so rich in idiom that biological function is difficult to infer from sequence alone. Even regions that code for proteins are problematical because of imprinting, alternative splicing, RNA editing, and other complexities. Lynn Caporale has done a great service in highlighting some of the major challenges in contemporary genomics."--Dan Hartl, Higgins Professor of Biology, Harvard University, and Member National Academy of Sciences"This timely, critical evaluation of...undeciphered genomic information is of interest both for life scientists and for all those who are fascinated by the natural driving forces of life and its evolution."--Werner Arber, Emeritus Professor of Molecular Microbiology, University of Basel, Switzerland, and Nobel Laureate in Medicine"The book, through paradigmatic experiments and analysis...points to avenues of research that could lead to a much more thorough understanding of the combinatorial wealth of surprises the genome still holds for us."--Dennis Shasha, Professor, Courant Institute of Mathematical Sciences, New York University, and editor of the Oxford Series in Systems Biology