Folic Acid Plus 120 Capsules by Ortho Molecular Products
To ensure the biochemical pathways that facilitate the conversion of homocysteine to less harmful molecules are supplied with the necessary co-factors and precursors. Several of these ingredients have been shown in clinical trials to reduce serum homocysteine levels. Why These Natural Ingredients? Vitamin B12 A required co-factor in the conversion of homocysteine to methionine via the folate pathway, vitamin B12 deficiency is common among vegans and the elderly. Vitamin B6 Vitamin B6 is known to be deficient in the typical American diet, particularly the elderly. Even low doses have been shown to lower homocysteine levels in elderly patientsƒ''ƒ''even among those previously supplemented with folic acid. Betaine (TMG) Betaine (trimethyl glycine, or TMG) acts as a methyl donor to homocysteineƒ''ƒ''converting it to methionine. This conversion pathway occurs in the liver and kidney and may contribute to homocysteine reduction in some individuals with very high methionine, or after ingestion of high levels of methionine. Folic Acid A required component for the conversion of homocysteine to methionine, Folic Acid supplementation reduces homocysteine levels as demonstrated in many clinical studies. Regardless of initial homocysteine levels, increased folic acid supplementation (up to 800 mcg) has been shown in research to enhance an increased homocysteine lowering effect. Those with higher initial homocysteine levels had greater lowering effects with Folic Acid. Low levels of daily Folic Acid intake have been associated with high serum homocysteine levels, especially in the elderly. Current research is showing that aggressive homocysteine management is more beneficial than previously thought.