Signal Transduction, Second Edition
A reference on cellular-signalling processes,Signal Transductionsecond edition details the sources, key observations, and experiments that set the scene for recent and current scientific endeavor. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors.Signal Transductionsecond edition further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fate decisions, cell differentiation, and cell transformation. This timely revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes.