Adrenaline
The most complete and detailed book ever written on Adrenaline. Hoffman  presents a fascinating account of the history-from the earliest days of  its discovery to its most recent clinical and therapeutic developments.  (Edmond H. Fischer, Winner Of The 1992 Nobel Prize In Physiology Or  Medicine)Adrenaline has long captured the attention of all flavors of physicians, biologists, and storytellers. Now, happily,Brian Hoffmanhas captured the complete 'biography of adrenaline' in substantial detail. The story and science are delivered with just enough--but not too much--technical detail, and numerous vignettes make it a very human read. (Alfred G. Gilman, Winner Of The 1994 Nobel Prize In Physiology Or Medicine)Hoffmanhas done a beautiful job of integrating the story of scientific discovery with commercial application, demonstrating the ways in which this is truly a circular process with both discovery and application happening in both industry and academia, rather than the way it is often viewed as a simple matter of companies 'scaling up' discoveries in university laboratories. (Carla C. Keirns, M.D., Ph.D., Stony Brook University, Author Of measured Breath: A Short History Of Asthma)Hoffmanhas written a study of adrenaline for nonscientists...It will be of definite interest to students of biology, chemistry, and the health sciences, or anyone interested in the history of medicine and medical research. (Rachel Owens Library Journal (starred review) 2013-03-15)[Hoffman's] 'biography of adrenaline' is medical history at its best, revealing the blend of genius, guts, and luck that transformed a hunch into a breakthrough--from 19th-century physician Thomas Addison's insights into the function of the adrenal glands to the beginnings of endocrinology (and the surprising use of hundreds of sheep thyroids to cure a human patient), the heartbreaking Nobel Prize snub of a canny Japanese scientist and biotechnology pioneer, and the myriad other drugs developed after the discovery of adrenaline. Hoffman notes that there's still much to know about the relationship between the body and brain when it comes to triggering emotions, but in the meantime, this thoughtful and exuberant exploration will satisfy both professional and lay readers. (Publishers Weekly (starred review) 2013-01-28)The first hormone ever discovered, adrenaline is associated with terror,  stress and excitement and is behind animals' fight-or-flight response.Hoffman,  a professor of medicine at Harvard Medical School, explores the  cultural significance of adrenaline and its history. The stories include  those of a murderous nurse who used the untraceable hormone to induce  fatal heart attacks in her patients, industrial chemists' race to purify  adrenaline for drug use and the myth of the chemical's power to raise  the dead. (Marissa FessendenScientific American2013-04-01)AsHoffmanbeautifully demonstrates, adrenaline is part of a  whole host of fundamental physiological processes besides fight or  flight. It influences our emotions and is part of the cycle of sugar  metabolism and our daily circadian rhythms. (William BynumWall Street Journal2013-04-26)[An] illuminating study of science history. (Hannah HolmesWilson Quarterly2013-04-01)