The lovable trio of super-heroines from the hit Cartoon Network series returns in their second Game Boy Advance adventure. This time around, their teacher, Ms. Keane, sends the Powerpuff Girls on a playful scavenger hunt. Too bad the evil Him has other plans in store for the super-powered group. The girls must work individually and as a team if they want to complete the scavenger hunt of ten Townsville locations unscathed. Each girl has her own unique mission to undertake while attempting to complete her checklist of hidden items.