New Haven's economy originally was based in manufacturing, but the postwar period brought rapid industrial decline; the entire Northeast was affected, and medium-sized cities with large working-class populations, like New Haven, were hit particularly hard. Simultaneously, the growth and expansion of Yale University further affected the economic shift. Today, over half (56%) of the city's economy is now made up of services, in particular education and health care; Yale is the city's largest employer, followed by Yale – New Haven Hospital. Other large employers include St. Raphael Hospital, Smilow Cancer Hospital, Southern Connecticut State University, Assa Abloy Manufacturing, the Knights of Columbus headquarters, Higher One, Alexion Pharmaceuticals, Covidien and United Illuminating. Yale and Yale-New Haven are also among the largest employers in the state, and provide more $100,000+-salaried positions than any other employer in Connecticut.[citation needed]