jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
>Hydroxycholorquine is interesting [1] both as an anti-inflammatory and immune modulator. The Azithromycin probably does nothing against nCoV-2 but may well help control secondary infection.

I had no clarity as to why azithromycin had improved the outcomes in that study to 100% of those treated with it, when HCQ didn't. That's very interesting.

Maybe you could clarify something else for me. Is there any information about whether these two drugs together could function as a prophylactic, or is this something patients have to be administered at the beginning of symptoms, or is this something that can be done late in the course of the disease?
I played brass instruments for about 8 years in school; even playing the tuba didn't really help me with breath control.

I was lazy and apathetic, so the fault was mine, but it's just worth noting that while it may be helpful it's not sufficient.
Reminds me a kickstarter project I backed years ago called ScanBox. I still pull it out from time to time to scan documents when traveling, and have used it once or twice for a live document scanner, though the sides of the box make it difficult to get your hand into.

These days our team either uses the built-in whiteboard functionality in Zoom, or jump into a Google Drawing or Slides document for the live collaboration.

Sometimes I'll also use Zoom's AirPlay functionality to share my iPad screen and use an app like Notability to share. Though that's only one-way and not collabarative.
I haven't used it personally but I've heard good things: https://www.getlektor.com

Generates static files while also providing an interface for edits.
I prefer not to add an extra step for newbies devs contributing to my open source projects. So if someone makes a PR and it's not well formatted, not a big deal.

For work, sure agree.
Officially, yes. Unofficially, there was Gus (65816, if you want to be pedantic, though Gus necessarily ran Apple II software as well).

https://en.wikipedia.org/wiki/Apple_IIGS#Gus
You should take a vitamin D supplement all the time. There is no way you can get enough from diet or the sun. It is the steroid for the immune system. I would recommend the following 3 vitamins to strengthen the Immune system.

D,C and Zinc. D is a fat soluble vitamin which means take it with some fat (in a meal or with a fish oil supplement).
I'm told it's like quitting smoking. If you still find ways around the hurdles you put up for yourself, you're never gonna quit.
Maybe correct. Ideally I'd like them to make me an offer based on what they think I am worth, considering market rates etc.

However if they insist on me revealing my salary, I am going to assume its so they have try and gauge how much it would take to make me jump to them, which is (in my mind) on the same ethical level as my exaggerating my existing salary to try and negotiate a better deal.
This experiement was featured in the documentary Dogs Decoded, here:
http://vimeo.com/19472436#at=1870

The whole documentary is worth watching, but the fox domenstication part is especially interesting.
>Unfortunately, and I hope this is not your experience, the way I understand the state of affairs in gaming in general is that if it's not as gorgeous as Mass Effect or as addictive as Candy Crush you're not likely to see many people caring.

This is only true for games on mobile platforms. The Skinner box horseshit you find in the App Store and on Google Play, will not translate into success on PC or console, because people who play games on PC or console actually want good games and are willing to pay for them.

Basically, don't make games for mobile, is my takeaway. Or, at least, don't target that platform exclusively or even primarily.
Why query open extraction data when there are billions of triples available via the semantic web?

Movie queries: http://www.snee.com/bobdc.blog/2008/11/sparql-at-the-movies....
Geographical queries: http://geosparql.appspot.com/
Misc queries: http://sparql.me/queries.php
Once someone has been exposed and recovered, they should have the antibody concentration required to be become a donor themselves.

The required number of cells we’re taking about is high enough that you’re not transfusing A->B and then recovering A from B’s plasma and going on to give A->C.

But while B is infected they will make their own antibodies and after they recover they could then be a donor as in B->C.

As TFA mentions, China doesn’t even bother testing the level of antibodies, they just collect the plasma from anyone recovered. 90 tons to Italy... is a lot of plasma.

At least for IVIG the plasma is pooled from a large number of donors for each transfusion ultimately given to a patient. So it’s more a question of the average antibody load than needing to gauge each individual donor’s levels.

> Each IVIG preparation is made from the pooled plasma of 3,000-10,000 blood donors, which is then purified to contain more than 90% antibodies. [1]

I think we need to start collecting plasma from recovered positive cases today. I get that for a trial you do want to have a measured baseline of antibodies. But we can start stockpiling and pooling COVID antibody plasma even without the antibody testing.

[1] - https://www.rheumaderm-society.org/ivig/
Yeah, no kidding. I started thinking, "What makes you so fucking cool and unique to deserve all of this? Have you seen what people in India have to put up with to get a tech job? Why do you consider yourself better than them?"
Did that take you 30 seconds?
These are fantastic, what a great find! I can just imagine these on the wall of Flynn's office at Encom in 'Tron' ...
Elixir, on the other hand, is still a bit bloody on the edges (and the MVC-ish frameworks for it are very much bleeding edge), but because it's built on the same foundations as Erlang, it ends up getting a lot of its benefits (and a lot of the existing ecosystem), which puts it uniquely in-between "boring" and "shiny".
I think the type of office space needs to meet the group's work. If solitary quiet work is required, you need either lots of quiet spots or a liberal telecommuting policy. If you need lots of communication, open is fine.

I'm surprised that open works there, but Zuckerberg is a developer and has hired most of the senior team. They must have data that it works for them.
The key component is the hub/switch chip.
The four POWER7 chips in a compute node are
connected to a hub/switch chip, which serves
as an interconnect gateway as well as a
switch that routes traffic between other hub
chips. The system therefore requires no
external network switches or routers,
providing considerable savings in switching
components, cabling, and power.

Sounds a bit like the design SiCortex had for their machines (before cashflow interruption killed them).
Some people are downvoting anything related to standing up for our rights -- http://news.ycombinator.com/item?id=1898362
A vague mental checklist I've been accumulating:

* Why didn't I stick with my last idea?

* Could I make that idea simpler?

* Could I reuse that idea elsewhere?

* Why am I not motivated to work on this idea (any more)?

* Could I change it around so that I am?

* What are people looking for?

* What are people NOT looking for?

* What ideas are already floating out there, that haven't been popularized, but could be done better?

* What ideas are getting too much hype and attention, so that I can filter them out?

And more recently:

* Is my idea trivial enough not to scare me?

Because it often happens that I'll end up with ideas that take serious ambition(learning, funding, research, what-have-you) to reach any kind of "viable product" - minimal or not. They involve too many sexy technical challenges, or difficult dealmaking, or time-consuming/expensive content creation. That in itself is a warning sign that I need to take what I'm doing, slice up the ideas again, and reassemble them at smaller scope, because if I try to get too ambitious too quickly, the risks go way up.

The worst part is that the more skilled you are at any one thing, the more comfortable you are with overscoping that thing and going well beyond what is necessary to ship, to the detriment of everything else. It's a good reason to get some form of collaboration going, since it will average out your perceptions and automatically bring them "closer to the market."

(And, ironically, collaborations online have an incestuous undercurrent: talent will hide within their preferred watering hole and wish and whinge about what they could do, when they need to venture elsewhere to find the diversity of skills and ideas to achieve something bigger.)
Who here is developing products relying on Twitter for their primary data stream today?

They had the world by the tail.
I agree, the technology is there to do this (use client certificates for site login) exists today - StartSSL is one place that does this.

The problem is essentially that moving your certificate store around is not a task that Joe User can accomplish, because the UI sucks. (Oh, and I also agree that this problem also exists for browser-based password stores).

Build a better interface, and it might just work. For example, I should be able to roll up to a new browser, login to some "home site" (whether run by Apple, Google, Firefox or whoever) and use my single username/password to download a client certificate, that then authorises me to login to my accounts on Twitter, Facebook and so on. Ideally, I could request a time-limited temporary certificate, so that it becomes useless after I've gone.
I see this theme over and over again for businesses and organizations as well. One of my favorites, Good to Great talks about "Stop Doing" lists. Jack Welch pushed GE to end the businesses at which it couldn't be number 1 or 2.

In smaller organizations, it is worthwhile to occasionally take stock and realize the extraordinary number of things that you're doing that you have no idea why you do them. Most of those have no value.
It's nearly in the job description of every software engineer to create things that ease people's workloads or replace their jobs entirely. I bet Stallman's projects, and the free software movement itself, are responsible for the non-existence of numerous jobs.

Also: basic income, or whatever it is that will make sense when there aren't enough jobs to go around, won't be preemptive.
Idk man, I know several vegetarians who would serve "Chicken Salad" without thinking to mention it's actually seitan (or whatever)

Not maliciously, of course, but long-term vegetarians get used to saying "chicken," "beef," etc. for fake meats.
Modern taxis fail every one of these "tests", so the fact that RMS wouldn't use Uber but would continue to use taxis at all is merely RMS riding a hatred bandwagon in an effort to stay relevant.

Fortunately for us, he hasn't said anything remotely new, so we can continue to think of him as the 20th century man he is.
FB seems to have a too-good ability to swindle entrepreneurs into believing they will keep their independence. Oculus suffered the same fate.
People might be a lot more sympathetic to factual criticism of left wing political violence if mainstream Republican politicians didn't frequently lie about it, up to and including politicians today who are claiming that Antifa was responsible for the attack on the US Capitol.

When so many loud (and often elected) voices say Antifa or BLM have "burned cities down" or other such outright fabrications, it's hard to take the genuine criticism seriously.
This idea of massive voter fraud isn't something that had entered the conversation until it was used as an imaginary defense for someone who has been unable to accept any loss or defeat or even apologize for any mistake he has made. (He also used it when he won, of course. But it is a unique construction that has been manifested into being by him.)

This is a man who, in what any normal person, could admit was a mistake when tweeting about a hurricane having effects in Alabama. Instead he doubled down, tripled down, forced federal employees to make statements that he was right. He even drew sharpie on a map to extend the prediction cone because it didn't show what he said.

There is a clear pattern of behavior here.

Additionally, those who are alleging massive voter fraud in public did not make those statements in court, because it would have actual consequences. Every state certified their results, including those with republican leadership.

So you either have to buy in to extraordinary claims of all kinds of (in many cases provably false) of voter fraud and a massive apparatus (Deep State) working against Donald Trump or accept the much more obvious and plain result.

If you listen to the call with Georgia, when the Secretary of State pointed out that they had investigated several of the claims, Trump's response was that the investigators were either incompetent or actively working against him.

It goes beyond the pale.
I would assume they‘ll appeal and go to Supreme Court then the ruling would apply everywhere in the UK. But even then GCHQ is in England wouldn’t their actions fall under English law?
If you check the "completed listing" box, most of the ones that sell seem to be doll clothing or other collectables. Half of the human clothing listings that sold are skiing "bunny suits" https://www.ebay.com/sch/i.html?_from=R40&_nkw=bunny+suit&_s...
I agree arXiv and Sci-Hub are useful. In the case of arXiv it does indeed cost money to run but not much as they are taking in PDFs and storing them without review, copy editing or curation. And that is fine. But arXiv has not replaced journals still. Getting work disseminated has not been an issue since the dawn of the internet. And that is not expensive either.

The service Elsevier provides albeit at a high margin and predatory business tactics is more than just archiving and displaying a PDF. And Sci-Hub is stealing the extra value they provide by curation, and peer review facilitation. We might agree with it since they aren't a nice company but the costs of copy editing, curating and reviewing those papers is not being done by Sci-Hub they are just doing the cheapest part of the process by being a repository for paywalled papers. They aren't being more efficient publishers by getting the value add part for free. Someone has to pay for that part. And if Sci-Hub just hosted non pirated work that was not reviewed or copy-edited it would be just as laudable as arXiv.
Are you asking, at what percentage DO the tolerant actually flip to become the intolerant? This is a good question, though probably impossible to answer with any precision.

I fear that it happens a lot more frequently than most people are willing to admit.
Here's some data analysis that addresses your general concerns, by digging in to the data. https://fivethirtyeight.com/features/why-statistics-dont-cap...
> "If you're based outside of US & Canada, but work remote for US or Canada office of a company, feel free to sign up."

This was the case I was curious about. Thanks for the clarification.
phys.org is often just regurgitation of press from original sources, typically university press sites.

Here's a better source URL:

http://www.jacobsschool.ucsd.edu/news/news_releases/release....
This seems cool.

How portable is the actual filter code? It seems to use Accelerate framework.
By far not the most illegal project.
They were, but then they hit funding issues in spring 2020 and appear to be scaling back their US expansion.

https://techcrunch.com/2020/04/09/monzo-to-shutter-las-vegas...
I guess it depends on what YC is trying to do. You have to remember a lot of investors shy away from biotech due to the huge capital investments that need to be made for new drugs or devices.

What I've noticed with the latest YC biotech start-ups is they tend to be much more focused on ideas that don't require a huge amount of capital (diagnostic platforms, biofuels, etc).
Do you have the code on GitHub (or elsewhere)? I'd love to read it.
> I will not speculate on your real intentions here, but i will let you know that everything you have done looks like you have ulterior motives. The post you made, while wordy, utterly fails as an excuse or even apology, the last of which you are due for.

This is hyperbole, unnecessarily accusatory, and counterproductive. Nothing above made it look like Ryan/Slack had ulterior motives. You disagree with how they interpreted things.
ES6 admittedly borrowed a lot from Python. I just wish Guido had been successful getting Python supported as a first class language in Chrome; that might have actually given us a choice in the browser. Even then, I find it hard to imagine that ALL other browsers would have followed suit.
There's a RadioLab episode where they explore this type of self-discipline (among other things). When a woman wanted to finally quit smoking, she told her friend that if she ever smoked again, the friend should take $5,000 out of her bank account and give it to the KKK. She couldn't bear the thought of her money supporting that group, and she never smoked again.

Edit: Here's the episode http://www.radiolab.org/2011/mar/08/ It's really quite good, like most RadioLabs.
I agree, in addition javascript is not easy to develop in. Yes, it's fun and fast for little projects. But do I want to stake my future upon a huge javascript codebase? I'd rather not. Navigating through javascript code is beyond cryptic at times.
How is the "walled garden" anti-competitive. It doesn't stop anyone from writing applications for android, WebOS, etc. Apple is selling a hardware experience. We have a choice, use IOS devices with the walled garden experience, or use an alternative like Android or WebOS devices. Furthermore, "honor" has nothing to do with the ability to write apps for a platform without paying a fee. This is not similar to Microsoft's anti-competitive practices in the past.
Except there's evidence that the soluble fiber in fruit helps moderate the fructose absorption in your gut (this is completely separate from the GI index, which is about how it affects your blood sugar levels). Unfortunately a lot of studies only look at macronutrients in isolation and ignore the (for example, vitamin C help calcium absorption).
Glad you liked it. Yeah, my R is a little rusty but hopefully you got the general idea of gathering stats and then tracking them to see if you can improve them.
KashFlow, London - Front-end developer

http://www.kashflow.com/blog/front-end-developer-vacancy/

At KashFlow we are not shy of taking the road less travelled. Right now we are redefining how SaaS products get delivered by building a first-of-its-kind application.

Bucking the common trend to build multiple native apps, which we feel is the antithesis of SaaS development, we are building a responsive single page web application. We don’t know of any other large scale apps (certainly none in this sector) that are targeting so many devices with a single codebase. But we are not about sticking with the pack.

That’s where you come in. We’re looking for the Indiana Jones of web development, a front-end dev who can navigate through the multi-platform/device/browser jungle that is the modern web.

You’ll be joining a team of passionate web geeks in our London office working for a profitable, fast growing startup. We’re not dependant on rounds of VC funding to stay afloat and your work will quickly find it’s way into the hands of thousands of existing users.

What you will bring to the team is technical expertise building interactive UIs and a wealth of experience making web applications work across different devices and browsers. Bonus points if you’ve got experience working in a client side application architecture as well.

You are obsessed about details. You do a sneaky victory dance whenever you knock 7ms off render time. You do more than just make things work. You come up with ingenious and elegant solutions, and you understand the quirks that make browsers behave differently. Although design isn’t necessarily your thing, you still work tirelessly to achieve pixel perfection.

You’re someone who stays up-to-date with what’s happening at the leading edge of web development. You easily formulate your own ideas and are able to make clear arguments for your opinions.

Core Skills

* JavaScript

* HTML/CSS

* RWD

* Code profiling, perf and optimisation

* Tooling (e.g. Chrome DevTools, the Command Line)

* Best practises (be prepared to write them)

Bonus points!

* Client side application frameworks, i.e. Backbone.js (hint: we use Backbone.js)

* Scrum/Agile

* Version control

* SASS

* REST (API, not sleeping at your desk)

Type: Permanent

Hours: Mon-Fri, 9:00-17:30

Salary: DOE

Benefits: Private medical insurance, 21 days paid holiday

You need to be ambitious and able to turn a list of problems into a list of solutions. We’re a fun loving office so a good sense of humour is expected, not to mention all four of the attributes listed at http://www.kashflow.com/blog/i-p-e-a-the-four-attributes-you....

If you think this is you, then send me an email (daniel kashflow com) with your CV, a link to your GitHub profile, salary expectations and a covering letter explaining why you want the role, as well as what you bring to the table.

Please note: NO AGENCIES.
Speed and user experience!

Fullscreen Webkit animations are normally jerky and slow. Trying to do any form of complex graphics (canvas bitmap data for example) is a no hoper.

Overall phonegap applications (at least the ones I have seen) are just not as polished as native ones.
So the Right has found another medium with which to elicit irrational emotional excitement like oh-so-many reality TV shows from its inbred voterbase... news?
> If Google voice were so innovative and amazing it would be something I wish I could get.

It is. When I posted my comment, Google voice was the main example I was thinking of (but certainly not the only one). The fact that you don't know about it is part of the problem. It'd easily be on the top of the app store lists if it was available. It just goes to show that because of Apple you don't even know what you're missing.

Your VLC example doesn't make any sense. You can watch whatever illegal movies (and illegal music) on your iPhone all you want using the built in software. You'll never get VLC, not because of anything illegal, but because "it duplicates functionality already existing in the phone". That's it.
Hope some European ex customers sue FB based on GDPR.
It's a lot easier to point at a fact everyone knows (Moxie took government money) than it is to find an exploitable bug in Signal.

This article is waste of time.
Someone ate their Wheaties.
At least one reactor had to be shut down as well, because the cooling tower froze.

Winterizing is the answer, no matter the power source.
Correct, government did not force Parler to shut down.

> If the crypto was effectively unbreakable, it would not be recommended by big companies like FB, Google, etc...

This claim falls apart given that Google started encrypting traffic on private links after learning of us gov snooping on their traffic. Also, why would Google care about breaking signal traffic at all?