jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
As I understand it, having had Hodgkins when I was younger: Lymphoma will be called out specifically because lymphoma is potentially a relatively simple mutation. Cancer needs a bunch of unusual major characteristics from cells, and the lymphatic system already has all but one of those characteristics, it makes cells that are intended to wander about the body (whereas say your skin cells or brain cells are designed to always stay in one place), it sometimes makes lots of them (to fight disease, whereas most cells are replaced only slowly over a long period), however the cells aren't supposed to refuse to self-destruct. If a mutation disables the self-destruct in a lymphatic cell line now you've for a recipe for cancer.

So if it's just one or two mutations, on the one hand it becomes more likely that you get it (and we see lots of 20-something men get Hodgkins whereas obviously very few of them get stuff like lung cancer) and on the other hand it is easier to cure, basically just kill the patient slowly, cross fingers the cancer cells die first then you save the patient.

That's a very high level idea of the plan for the chemotherapy + radiotherapy used. In medicine the goal is to find reliable ways to do this that kill the fewest patients while reliably getting rid of the cancer, and then also aiming not to make the side effects suck too badly when you cure people (e.g. my lungs are trashed so that I permanently have a mild cough, which wasn't a huge annoyance for a middle aged guy who frankly doesn't eat well enough or exercise anyway, but I can see it'd ruin your life if you were previously a world class athlete and now you'll never achieve that potential). But obviously Mother Nature could very easily randomly cure some people from a single mutation by luck.
In this snapshot of a moment, yes. But consider these things:

1. Space colonies, especially remote ones (e.g. not Moon, but Mars or Titan), are strongly motivated to be maximally independent as soon as possible. Whoever leads them must think about the possibility that the supply ships stop coming, either for some temporary disruption (pandemics on Earth, cough, cough, or even a war back home), or permanently (something has gone seriously wrong on the blue planet). And imports from Earth are expensive, because they have to be lifted out of the Earth's gravitational well. This means that the colony will try to produce everything necessary in situ for good reasons; such a colony will not be easily brought to its knees by a blockade.

2. It is easy to block a colony physically, but they will still be able to communicate back to Earth and argue their cause in front of the rest of the humanity. This will undermine the will of Earthly powers to maintain the blockade.

3. We are now in a rare situation when only one nation (the U.S.) is approaching the capability to send ships to the rest of the Solar System. It is not unlike the situation when only the Portuguese mastered the carrack and were the only ones to sail regularly from Europe to India in the late 1400s. But this situation will not last and I would guess that by 2050, at least five or six sovereign entities will have the same capability. By 2100 for sure. And their political differences will be exploited. It is unlikely that all of them would decide to start a common punitive embargo against a rebel colony.
Thank you. I have been thinking about buying a JQuery book, but I might try this one instead. It sounds promising.
I would point out that there is as much difference between your basic piece of ShovelWare and a real iPhone app as there is between a "Home Page" and a Web app.

In both cases having a deep understanding of the platform and the skills to build non-trivial stuff on top if it will be valuable after gold rush phase has passed.
Kind of like what happened to Microsoft.
Please do. I want something to point people to.
Count me in! makmanalp |at~ wpi ~dot| edu. Also, check out the HN group on airbnb.com
As meaningless as rss/vsize is on Linux, the "supervise" process from DJB's daemontools weighs in at ~ 340k/1628k on a 32-bit system.

DJB is not known for producing bloat :)

I think you'd be hard pressed to go below that number.
I had always considered the Clipper-Chip incident to hint at the tip of an iceberg.

Do you really think that was an isolated one-time event?
I have a fitbit and an Android phone. Personally, I'm in the segment of this market that would like my workout activity tracked in the background. I'm not likely to change my routine based on an app, but if I had an app that could automatically track the details of my exercises at the gym, I'd use it endlessly. Fitbit does this for running / walking, but not for individual exercises yet.
> [...] the number of books in a child's home is a much greater predictor of later literacy ability than the amount parents actually read to their kids.

Haha, YES! My decision to reverse the process of reducing the size of my giant library of dead-tree books after my first kid was born is JUSTIFIED BY SCIENCE! :-)

> That Hart & Risley book I linked to above has some data about how the cognitive benefits of asking questions depends on their grammatical structure.

I will definitely check that out, thanks.

[EDIT] Incidentally, the number-of-books-matter thing fits well with my hunch that modeling behavior is extremely important to encourage similar behavior in children, assuming the adults in those households tend to read more than the average. It strikes me as crazy to expect kids to, say, enthusiastically take violin lessons, read, and play sports when their parents never play music, never read (except to their kids, perhaps), and rarely exercise at all let alone actually play an organized sport.
Then maybe you would prefer something like micropreneur where the mantra is "start small stay small".

I myself have small food business and also hosting business. Nothing fancy that HNer would be interested in, but its a nice side income to have. I spend 2-3hours a day on this.

patio11 always said that "there's always money in small niche market". No truer words were ever spoken. Most small business are tackling niche problem anyway.
> Do not trust them for accurate results.

Ookla speedtest properly transfers data and divides to find throughput-- both with the website, the GUI app, and their CLI program. The open source speedtest-cli that uses their infrastructure is hampered by only one connection and can't seem to ever report higher than 300mbps.

Fast.com is ... a little optimistic about transients getting transfers started and sometimes reports numbers 5-10% too high.

Neither is grossly wrong by an order of magnitude. Maybe there was also wifi around and simultaneously connected, confounding the situation? Easy to end up in a situation where all your internet traffic is going over wifi (because e.g. your dhcp client replaces the default route with one going over the wifi interface), and all your local traffic goes over ethernet.
There was more content previously (but no install instructions).

The submission reminded me of: https://news.ycombinator.com/item?id=7126818

Here is an IRC log about it:

http://log.irc.tymoon.eu/freenode/lisp?around=2015-01-25T15:...
Wouldn't be surprised Putin broke up OPEC+ to cover up the decision of extending his reigning period to President for life. MBS and Putin are BFF's and this was probably MBS taking one for the team.
Seems like in times of need ventilators can be rigged to support multiple patients:

https://onlinelibrary.wiley.com/doi/pdf/10.1197/j.aem.2006.0...

https://www.youtube.com/watch?v=NER2h9STy7Q
> But what to do with such a person if you can't/won't ban them from posting?

How about ignoring details and only focus about the technicality?

Looking at that way too long thread, both sides seem to be blamed on way or another. From what I can see, HDR support missing is actually an issue. Instead of letting him know they accept the bug, they are feeding him with rhetorical questions .

Developers should not worry about this people. They should not take pride in making people happy but take it from knowing millions and millions of people will benefit from your code. No matter how much of an asshole the bug reporter is, a bug / missing feature is just that.
I'm not trying to convince you to like or even give much of a hoot about David French. I'm saying is that there's more there than you can derive by mere keyword keyword matching, you asked my why I think that. I told you why and now you're telling me you can also derive that by keyword matching and additionally, I should provide citations. I think we've sucked what limited interestingness there was in this topic dry.
This is a great (the only?) way to start. One thing I think is also really important is to be a domain expert in the field of your idea, or be ready to find co-founders who are.

Obviously domain expertise isn't totally applicable for something like having a great idea for a new spin on a social network, but where you are getting into a vertical (like healthcare) it is probably essential. Otherwise you won't know how to make a product that the professionals in that market truly want.
> But the hardware is just the first step. Boyce says the company will approach institutes with an enticing offer. "We will sell you these cheap systems, or sequence your samples ourselves, but there is a catch. After a certain time period has elapsed, you have to give us those samples for our open source database."

Awesome. Their license requires you to release your sequence data to them. It's as if by using GNU/Linux, you had to release your documents and music publicly.

Although generally I support freedom of genetic information, this has to be done at the level of the IRB and with informed consent from the people giving you the DNA. As an aside, the article grossly misstates what a biomarker is.
Interlingua gets less press than Esperanto, but I think Interlingua is a much better interlanguage -- interlingua is a latin-derived language that has some modern features and the corners squared off; people who know English or other european languages with a lot of latin influence can read Interlingua with remarkable comprehension without any training, take a look at...

http://en.wikipedia.org/wiki/Esperanto_and_Interlingua_compa...
Agree with the gist of this, but it's not just the geeks that are getting fed up with Apple. Apple's core "black t-shirt wearing design hipsters" user base are very annoyed with the Adobe/Flash situation which is causing them even more cognitive dissonance.
Spam-following people on twitter to promote your app: bad idea. I reported you as a spammer.
The reason it works is because it moves right past giving the customer the 3rd option, no meeting.

So by giving two choices that are good for you most people will pick either one, not even realize there are other options. People like 'multiple choice' and don't do well on 'open questions', this is probably related somehow.
Thanks Bill, need to drop by we-pay it's been a while.
I spent a few weeks last summer in Western Africa, mostly Burkina Faso, but did spend a week in Ghana. I understand it is the most stable in west Africa and growing the fastest but I, as a westerner coming from one of the top 10 or so poorest countries in the world(Burkina), didn't see as dramatic a difference in Ghana than I had expected. I unfortunately never made it to Accra.
How's the tech scene in South Africa? I would imagine it has its share of startups and investors, etc.
Yes, exactly. Developing a web application is basically the act of putting square pegs into round holes, over and over...
Well, just this week a purchased a HP Stream 7 Signature edition for £50 (~=$50). Microsoft is definitely in the market.
I am not sure that it does. Honestly responding with "I haven't tried that before" seems to be harder than it sounds.

I would trust a master to take the appropriate amount of time to do a research spike or to bring in the right people in and understand how to get going.
It's a demo.

Literally. Like in the demoscene sense.

And it doesn't matter that the robot couldn't possibly coordinate everything in the video on is own. The software doesn't just have to coordinate high level "go here, move like this", you also have the lower level coordination that sits between the collision avoidance and basic driving etc and the $gcode_variant driving the servos. I'm guessing that stack gets a major overhaul every time one of these videos gets made, like almost every Hollywood movie has a massive "software development" section because of all the artistic direction that needed new or changed functionality.

The original video showing Spot moonwalking had the most imperceptible of splices in it right at the end of the moonwalking bit. Several months' worth of development alongside careful use of multiple scenes in this newer video have mitigated the need for hacks like that. It's nice to see.
Your comments belong on Reddit, no HN.
Tl;dr : Apple decided to attack the Qualcomm business model and planned a 5-10 years strategy against Qualcomm. Shown by Apple Internal document in court. And later lost ( or settled ).

Apple took Qualcomm to court due to 4G/5G patents dispute. And made number of claims which were false, possibly inaccurate or lying by omission.

I initially sided with Apple, quoting Tim Cook

“Despite being just one of over a dozen companies who contributed to basic cellular standards, Qualcomm insists on charging Apple at least five times more in payments than all the other cellular patent licensors we have agreements with combined,”

Fives Times More than others Combined. That is ridiculous. We knew Qualcomm were expensive, but we never had an actual number or up to date figure. This allegation was repeated in all mainstream newspaper and website. There were at least Six other major companies ( Nokia, Samsung, Huawei, ZTE, Ericsson Intel/LG ) with broad wireless patent portfolio. That is Qualcomm = 5x where other companies = x/6. Or 30x difference if x were divided equally between all companies.

This got people furious. And I did too. Despite knowing Qualcomm have the best, this kind of multiple were unheard of.

That is until you sit down and start to run some numbers. It doesn't make any sense. You can add up the low end, high end estimate of all there other six companies patent licensing cost in their investor notes and rounding to the nearest number and it would still be an order of magnitude off the figure Apple were trying to paint.

Apple argued Qualcomm made double dipping because they were earning profits from Qualcomm Modem itself, and they are still charging for patents. As if the design of the Modem itself doesn't cost anything?

And numerous other claims.

At the end instead of going to PR battle with Apple, Qualcomm has shown immense restrain. I guess they knew they would win. And since then I have tremendous respect for their CEO, Steve Mollenkopf's professionalism.

The only person who bother to report all the fact from both side was Shara Tibken from Cnet. Who actually sit in every Apple Qualcomm trial ( There were multiple ) and tweet as well as post update. You can read about it here [1] to make up your own mind.

[1] https://www.cnet.com/news/apple-and-qualcomm-settle-heres-wh...
Beautifully done Amazon. No one will ever comparison shop. They won't price check. They will happily order whatever the button is linked to for the rest of time.

Next up, buttons for kids, to get em hooked early. A Cheerio button! :)
On the other hand, cocking up an unfamiliar phrase in a spoken language doesn't usually result in accidentally killing the listener.

I haven't yet had a computer ask for clarification when I used tar or dd in an uncommon and destructive way.
Also when he visited a driving school in Scotland and asked how they kept the natives away from alcohol long enough to team them
If you didn't need a GUI, you wouldn't need this document.
My understanding is that if you declare

some_concrete_type *p;
some_other_type x;

then, for example,

sbpush(p, x);

will result in a type error as expected, since its core expands to:

p[some_index] = x;

So this is kind of type safe. There is an assumption that

((int *) <guaranteed aligned pointer>) + 2

will still be correctly aligned for any type. That's a pretty fair assumption on modern hardware, except maybe for SIMD types.
I guess if it doesn’t belong here then it will be off the front page soon enough
LinkedIn's "endorsement" section was under fire and now this.
As was already said, any webhosting package with email will do. Here is a selection of hosters in Germany that I find have a clean website an pricing structure and therefore feel less cheap and more trustworthy to me.

Hetzner: One of the bigger provider for hosting in Germany. They have their own datacenters in Bavaria.
Manitu: Smaller, they also have their own datacenter.
schokokeks.org: Small service run by a few techies. I'm sure there are a few of this type, I just happen to know somebody who is very happy with them.
> At market value they are something like $400 million in debt

I haven't followed that closely because I don't particularly care about MtGox aside from popcorn value, but I'm not sure how you would know that from the information that's currently public. As far as we know we kind of think we know the number of bitcoins they lost, but not the amount of cash/btc assets they still have.

Or did I miss something?
What is the significance of this, e.g. can we use this approach to build arbitrary material or even living tissue? I can't help but think of this video [0], it seems there may be commonalities between what's happening in life and simple cellular automata.

[0] https://www.youtube.com/watch?v=7Q9VyHJ1l2Q
Perhaps messaging should once again be built into the telecommunication infrastructure (like SMS) and billed along with voice and data.
A sitting president ignoring election results and inciting a mob to literally attack the Federal government in an attempt to subvert the Constitution is a very pressing issue. It's hard to solve big problems with a government that ceases to abide by its own rules.
So you're against sites censoring content that's considered unpopular but you'd like the HN mods to censor a certain point you call "trolling"?
Location: Sao Paulo, Brazil
Remote: Yes

Willing to relocate: Yes (Not preferred)

Technologies:

• Front-End: ReactJs | ES6/7 | TypeScript (learning)

• Backend: .NET Core | C# | Asp.Net MVC | Web API | Java

• Data: SQL Server | NoSQL | MySQL | DynamoDB

• Cloud: AWS | Azure | S3 | SNS | SQS | Lambda | Secrets Manager

• Packages & Tools: Redux | WebPack | NPM | Git | Jira | POM | Jmeter

Email: filipe.garcia1997@gmail.com

Résumé/CV: On Request.

LinkedIn: https://www.linkedin.com/in/filipegarcias

ABOUT: Full-Stack Software Engineer in the biggest investment bank in latin america, BTG Pactual, in the credit team. I am very open to learning new technologies and techniques that are not in my current stack, and I have a great desire for an international job opportunity, that is one of my goals. I can communicate in English, Portuguese or Spanish.
The folks that are pro-private company censorship always do that. It's the only way their argument works so they have to avoid the nuance that free speech has a law and a principle.

It's constant to read opinions like that in threads like this. We used to have this argument in the 60s where private businesses argued they didn't have to serve blacks since they were a private business. Political speech/activity is protected when it comes to labor law. It's not hard to see the law updated at some figure point. Discrimination is discrimination in my book, and free speech is paramount even the most repugnant opinions.
If only Trump had you as a lawyer, your airtight evidence could’ve been brought to court.
From the linked page, it looks like this occurred hundreds of years after Christianity started, and after it was already quite well-established, so it doesn't seem accurate to say that the Christian religion was designed, even if the new testament was.
I haven't read the article yet, but I would assume they want versioning, history, checksumming and verification. All that stuff is worthwhile, it's just unfortunate npm is such a heavy dependency to achieve it.
You don't see how breaking into the Capitol Building, during a dual session, with the express intent of disrupting the ratification of election results, because the loser of said election egged them on, is a more serious situation?
How common are laptops for gamers? I always build my windows boxes but I’m a casual gamer.
We do have a basic terms page (http://stacklead.com/terms) that needs to be clearer. Our goal is to help you automate this research and improve your sales process. We will never sell or share customer data.
Great advice! I would agree with everything except maybe that “I just had to hack something together…” always is a bad thing.

Especially from the business point of view this article stresses, it can be reasonable to 80/20 your way out of certain problems and then polish it in the future.
One problem is when an event like this happened in New Zealand, other retailers didn't accept new customers at this time. I mean, would you accept new customers paying 20 cents a kWh when the market rate is 500 cents a kWh?
Anecdote:

My son's soccer team from the city decided they wanted to make a statement against racism and kneel for the national anthem before games. At one of the suburban/rural schools, they were vehemently booed and yelled at by the parents and supporters of the other team.

(And the decision to kneel was made after a game the previous season against a different rural high school where my son's team mates were racially abused during the game.)
I think you'd find some evidence for historical poverty being one factor of several in cultural practices of bed sharing. Japan would be a notable exception (plenty of co-sleeping, unremarkable poverty rate).

I also don't think it has become much less common in communities where poverty levels have fallen. Anecdotally, my SO is part of a community originally displaced from India and now settled all over the world, where members have disproportionately become very wealthy. Bed sharing is absolutely the norm in those households, much to my distress when we visit her family!
How is it different from a squat? Are people not spreading their cheeks? Your body is still aligned the same way when you rest your elbows on your thighs.
The role of the BBC Micro wasn't just about what the kids had at home. It was about providing kids access to a machine -- many kids wouldn't have had computers at home. It was also about providing a framework, lessons, course materials, TV shows, etc all centred around development on a standard system. It's what encouraged other home computers to run BASIC (for example the Locomotive Basic, which is what the Amstrad CPC ran, was heavily influenced by BBC Basic).

The BBC Micro was a massive influence to the education of IT, to the home computing industry and to 80s kids (even if sometimes indirectly).
Thank you for this opinion! I completely hear you on forced-socialization ideas. I also understand that there is a place for work and a place for fun. However, I am curious on what you have tried or seen on top performing teams around building camaraderie and coming together - especially when remote.
> Support a physical store or they will disappear.

Exactly. Even though finding the part I was looking for (a LiPo charging circuit) was a pain, it was still priced the same as if it was online, and I could get it fast. And yes, the kid that helped find a locked up RPi pico for me was extremely excited to tag the rest of my stuff.

If I want to make sure that the store is still around, it’s important to keep supporting it. That’s been my basic COVID lesson.
Haha, just got the title pun. QT and Cute.
Anytime and anywhere you have a chance to. Be spontaneous and creative. You don't need a bed to have sex in anyways.