jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
tl;dr per this Nature article, there's different type of antibody responses, intramuscular vaccines are better at inducing the flavor of antibody that works in the lower respiratory tract (which is excellent at attenuating disease severity) but not the kind that works in the upper respiratory tract. Also afaict, sars 2.0 reproduces in the upper respiratory tract, and it's this type of reproduction that allows for disease spread.

i'm not a virologist nor an immunologist but this is my understanding of the situation.

https://www.nature.com/articles/s41586-020-2798-3

> it is important to note that natural infection induces both mucosal antibody responses (secretory immunoglobulin A (IgA)) and systemic antibody responses (IgG). The upper respiratory tract is thought to be mainly protected by secretory IgA, whereas the lower respiratory tract is thought to be mainly protected by IgG27,28,29. Vaccines that are administered intramuscularly or intradermally induce mainly IgG, and no secretory IgA30. It is therefore possible that most vaccines currently in development induce disease-preventing or disease-attenuating immunity, but not necessarily sterilizing immunity (Fig. 2).

> The lower human respiratory tract is thought to be mostly protected by IgG (IgG1 is most prevalent), the main type of antibody in serum, which is transported into the lung. The upper respiratory tract is thought to be mostly protected by secretory IgA1 (sIgA1). a, Natural infection with respiratory viruses induces both a systemic immune response, dominated by IgG1, as well as a mucosal immune response in the upper respiratory tract that is dominated by sIgA1. This process can lead to sterilizing immunity for many respiratory viruses. b, Intramuscular or intradermal vaccination leads in many cases to a strong induction of serum IgG but not to an induction of mucosal IgA. Although some IgG can also be found on the mucosal surfaces of the upper respiratory tract, the lack of sIgA often leaves an individual vulnerable to infection of the upper respiratory tract. c, Intranasal vaccination can efficiently induce mucosal antibody responses, thereby potentially providing sterilizing immunity in the upper respiratory tract. However, systemic immune responses are often lower after this type of vaccination. Currently, all SARS-CoV-2 vaccine candidates in clinical development are administered intramuscularly, and very few of the more than 180 vaccine candidates in development are designed to induce mucosal immunity. Although mucosal immunity might not be required to protect from severe or even symptomatic disease, it could be required to achieve optimal protection from infection and onward transmission of SARS-CoV-2.
But this wasn't a rally. This was literally them storming the halls of Congress to take back their country from what they believe are corrupt communist deep state agents. Why do they believe that? Because their leader Trump has been amplifying this type of conspiratorial misinformation on Twitter for the past 4 years
Deplatforming just encourages people to seek out alternative platforms to use that have conservative moderations instead.

Right wing going forward will not be going away. In fact, it will grow and the staunchness will become more hardline.
Thanks for these insights! I always knew that the underlying tech was fairly old, but I didn't realize development began in 2001.

I've been looking at the SDK thread in the iRacing forums and its definitely interesting to see how its structured.
While I agree that the woke corps certainly promote and endorse these groups, I still have a small amount of faith in the US legal system to seek justice. Meaning if Twitter failed to maintain their legal obligation to enforce, they'd be open to litigation.
It's interesting that your demand for proof requires a politician to have "pressured"/"threatened" Apple or Google, whereas to believe in Trump's culpability for what the insurrectionists did you will settle for him merely insinuating violence.
> we could react as fast as the different viral strains mutate

The number of mutations is proportional to the number of people currently infected. The faster the virus spreads the more variants will be created. The fact that the N501 variant spreads faster seems to imply that the rate of mutations is already in the process of accelerating.

It may make more sense to use evolutionary modeling and analysis of existing SARS-type viruses to create antigens robust to all expected mutations. Here’s one such bit of research:
https://www.biorxiv.org/content/10.1101/2020.11.17.387092v2
I think this is very relevant: I would personally avoid applying for a position in a company with a very problematic product.
(my bias as a C# dev will show here)
Most likely a professional association, with a test you have to take to call yourself a software engineer demonstrating basic competency in a couple of paradigms, and a rudimentary knowledge of patterns and practices.

It's 2015, there's no reason that anyone should be writing Big Object Oriented Code, without practicing dependency injection, basic mocking and testing, and other modern development principles. And yet, here we are, with millions to billions of lines of terrible new code written every year.
your code sounds like an excellent way for a programmer of CrapplyLang to learn perl ;)
It doesn't matter. They way they word the contract, it looks as if they could claim your firstborn as company property.
Sadly, only governments can break monopolies.
Isn't this just going to drive all the tracking serverside?

Hash up the tracking data in the app, send it back to the app's servers, send it to whoever you like? Same is happening with browsers and 3rd party cookies.
"The most compelling use case for making x86-64-linux-gnu as tiny as possible, with the availability of full emulation, is that it enables normal simple native programs to run everywhere including web browsers by default....I think we need compatibility glue that just runs programs, ignores the systems, and treats x86_64-linux-gnu as a canonical software encoding."

:)

Just a smiley, no other words!
https://9to5mac.com/2020/11/15/apple-explains-addresses-mac-...
Because no one else does this?

I have worked on creation of custom boot menu entries and this is basically a huge pain in existing technologies, like grub2. If you have multiple OS, every one of them must know, even a little bit, about every other one. This means that innovation in the early boot section is much harder than it needs to be, unless you want to take over entire computer.

It would be great if someone else had come up with the bootloader with “drop-in files” mechanisms, and pushed it to every major distro, but that did not happen in the last 30 years, so it is unlikely to happen anytime soon.

And yeah, I wish Poettering would make few new repos instead of pushing all under “systemd” umbrella... but it’s not a big deal, given he is finaly solving this major annoyance.
Engine code is very often a small, small part of what makes games "buggy". Bugs come in all sorts of shapes and sizes, but a majority of the bugginess of games that I've seen stems not from code, but from the large matrix of combinatorics that game developers can create for themselves in their designs.

Simple, contrived example: if I create an open-world game with open-world design, I can complete quests in any order. Maybe I can start doing a quest, and then decide to stop doing it halfway through, or maybe I can switch quests halfway through.

The test case matrix for this is now: every quest x every other quest. If some quest spawns a timer that will do something in 3 minutes, and something else forgets to stop it when I switch quests, that's a bug. Maybe the timer spawns some NPC, and it should stop when I switch quests. Or maybe the timer will reset some world state, and should fire immediately once I switch quests. But maybe not always -- if I complete the quest but the game internally 'switches quests' to the next one in the cycle, I don't want to despawn the NPC.

Is this code? Not really engine code, it's more like data, or scripting? It's not really the code that's reusable between games, and between engines; it's custom-built for the game's flow itself. That's where, in my experience, a good majority of "AAA bugginess" happens.
It's already like myspace. Facebook is giving me super trashy friend suggestions of random foreign women with slightly suggestive pictures, and aside from my demographic I can't think of anything I've personally done on or off the internet which would make them good friend suggestions.
Following a group of streamers at the same time is ideal for this. Currently you need to use 3rd party services.
> government systematically robbed IP from competitors

You do realize that's exactly how the US became an industrial power right?

The difference being that most companies were happy to provide access to their technology in exchange of reaping higher profits from penny on the dollar Chinese labor and expedited logistics

But ofc, you never hear that, or the fact that we are talking of a different country with different laws, the US is not entitled to enforce its laws in other nations after all
The scratches don't seem to match between the scans, so it seems that it is indeed his scanner glass that is scratched.
Just a word of advice, if you suffer from tendon pain and took flouroquinolone antibiotics within last 12 months. Never, take those again.

I have been dealing with widespread tendon issues for the past 7 years due to that medication. The black box warning reflects the issues somewhat. These should be last resort antibiotics but are given out in the US for suspected UTIs.
The problem is the imbalance between the mobility of capital and the mobility of labor. If it were as easy for Joe Iowa to move some place with a lower cost of living to compete for labor as it is for Joe CEO to setup manufacturing there then I'd be all for Globalization.
If you move that slider even just a few months to March 2020 you capture a doubling of the stock price, 1.5 years seems incredibly arbitrary as a cutoff point
It's worth pointing out that the author of that New York Times article, Mike Soraghan, has in his Twitter bio "Frac(k)ing is my life" and that he links to the same articles you linked to.

https://twitter.com/MikeSoraghan
Xbox in positives I guess... but I don't agree on the whole game division...
the "Games for windows" system is just horrible -
I tried, but didnt work in Chrome. Not that i want it to. Safari is the only browser on my mac and works almost fine.
caught myself at it while reading your comment, always good to know you're not alone
C'est la vie

Once you're suspect, you're suspect. If you've got the benefit of the doubt, you've got the benefit of the doubt.

Overall, that's probably more good then bad. We'd like to think we can be objective, but we probably can't. These crutches are there for a reason.
Isn't the Pandora overall more interesting? The screen is so much bigger...
Using vendor prefixes does not equal to being non-standard, from the CSS3 Working Draft[1]:

> there are situations (experiments, implementations of W3C drafts that have not yet reached Candidate Recommendation, intra-nets, debugging, etc.) where it is convenient to add some nonstandard identifiers to a CSS style sheet.

Most extension Apple used in the demo page are part of CSS3 Working Draft, including CSS transform[2].

[1]: http://www.w3.org/TR/css3-syntax/#vendor-specific

[2]: http://www.w3.org/TR/css3-3d-transforms/
how do you get around the Business Name / Trademark rules?
I am an anarcho-capitalist (Ron Paul's type of libertarian) and I think this kind of portfolio is crazy. Even in a total depression you can still do really well selling food, drinks, support software, ...
This is pretty much par for the course for hardcore libertarians. I have a good friend who is a staunch Paul supporter, invests with Peter Schiff and tries to convince me on a daily basis that the stock market and American capitalism is at death's door (I'm bullish on the stock market and heavily invested in it on the long side). This is common wisdom among the group- buy and hold gold because tomorrow the dollar is going to be worthless.
Wow, another article about identifying with a text editor. It's almost completely devoid of useful information, at that.

Flagged.

I'd like to see an article on using vi's ex mode to its fullest potential - there's a lot of power there, and many people seem completely unaware it exists.
Amazing job. This is exactly what I'd like to do in a couple years. I will definitely use this as my inspiration / guide.
Mmm. The CPU is the whole brain, and WoW is the totality of human behavior; so a more correct analogy would be: "I disabled the arithmetic co-processor and look, this character behaves erratically -- while the rest of the game seems unaffected".
I've never tried the original APL, but J and q are great interactive calculators, due to their terseness and overall structure.

For example, if I want to convert a 4-item vector to fractions of the total, I can write:

x <- c(1, 3, 2, 5); x/sum(x)
x=np.array([1, 3, 2, 5]); x/np.sum(x)
{x%sum x} 1 3 2 5
(%+/) 1 3 2 5

in R, python, q, and J respectively. In q and J, I don't have to type the commas, and many of the parentheses and brackets go away.

I know it seems like a trivial thing. It certainly is for code, i.e. stuff that you're saving in a file and intending to use later. But for an interactive calculator, it's important.

Clearly, if you're not doing very mathy work, things like this don't come up. But in its domain, it's very nice.

(Edit: TCL is similar in this regard: it doesn't require as many commas and parenthesis as other languages, making it a very good, well, tool command language.)
This question comes up periodically, check the archives.

Mainly, I'd suggest working through the puzzles at http://projecteuler.net/ . Once you solve them, especially if you don't feel like your solution is good enough, read through the forums and translate interesting approaches to your language.
Has anyone gotten one without showing up on this site?
http://addicted-gamer.com/cr48-tracker/

If so, I can stop compulsively checking it :)
The obvious counterpoint to that is that there is no give and take in the preparation of a filet.

The success of a development project, or software implementation depends just as much on involvement from the customer as it does for the developer or provider.

In the enterprise, this means setting up a project consisting of stakeholders from which you can gather information, get integration assistance, etc. In the single-project bespoke software or web development arena, it's even more important that the customer is able to provide good feedback, offer and direct according to their vision, etc.

Back to the steak analogy, what would be the remediation for the customer yelling "More salt! More salt!" and then refusing to pay when the final product is too salty?
There's a solution in Smalltalk that I'm wondering why no one's brought to Ruby. In applications where this pattern is useful, there's a class, Null, with the singleton null (in contrast to UndefinedObject and its singleton nil). nil raises an exception, but null simply eats all messages sent to it, much like the maybe monad you listed.

This makes it really easy to mix and match the two paradigms in your code: in places where it's okay for the object to just eat messages, you return null. In places where no value is a real error, you return nil. Either value can be converted to the other with a one-line statement, and to existing code, null looks like nil when queried (i.e., isNil returns true, ifNil: and ifNotNil: and friends behave as if null were nil, etc.).

Seems as if writing a similar tool for Ruby would be trivial.
This, along with automatically using an external monitor when one is plugged in, is the reason that I switched to the Mac for laptops.

As others are saying, it sounds like the suspend/resume feature works well now. I can add that at least on my multi-monitor desktop Ubuntu 10.10 will reliably automatically adjust when I plug in or unplug one of my monitors. I found this out accidentally and it was really a pleasant surprise.

Of course, as always with Linux, both these features probably depend on how well your hardware is supported.
Might I recommend the Color Computer for BASIC programming as an example of a highly useful and powerful version that's still being used today to create new games for the system, as well as a simple programmatic access to the peripheral interfaces.
I'm hoping it will get there eventually. The backup mechanism on Android has improved a fair bit from what it was at the start. It used to be that you had to have the backup file in the correct magic path before starting Signal for the first time. Now at least there is a dialog and you can pick the file whenever.

The usability issues for non-tech people have been getting less and less in the past years which is keeping my hopes up.
I wonder if Pence and the cabinet have already done so, in secret? Apparently it was Pence, not Trump, who ordered in the National Guard [1], and there doesn't seem to be any requirement in 25/4 that Pence and the cabinet inform anyone but the President pro tempore and Speaker that they have done as much.

[1] https://www.cnn.com/2021/01/06/politics/pence-national-guard...
Taxes to pay for government services are more like protection money than donations IMHO. If I were to stop paying, some angry people with guns would eventually come to my door to take me away.
I can confirm this. No one in my circles ever paid and the banner never went away.
Two years is a long time to stay in one job. Two years is an eternity for a team's headcount not to grow. It's virtually certain that you'll be a mentor to several new hires in that time. You'll also have a long head start on understanding the codebase and tools relative to many others who will be working with them. If you're not some kind of leader at that point, something's wrong.

Unless you found one of those rare teams that stays together for the long haul, but the experience with such a special phenomenon should make it more than worth your while.

If L4s are not getting opportunity to lead, they are on a sinking ship anyway and the smart ones are LeetCoding.

(Obviously this all reflects the crazy economic moment of the last 10 years in Silicon Valley, but so does the level system you're critiquing).
Reminds me of this seatbelt advert (warning: graphic) https://youtu.be/mKHY69AFstE
We is him, you is the people on the Capitol grounds. The rest of the message sets the context that this is clearly aimed at the protestors. I don't know what's preventing you from seeing this.
Yeah, the only reason it grew was because they invited a bunch of celebrities.

I listen to these rooms and these people hosting seem like they have experience in hosting live talk shows. Makes me suspicious.
if riots are the language of the unheard, maybe it's a bad idea to artificially make large portions of the american electorate unheard.
If busting the windows out of a Walgreens goes beyond a protest, so does busting the windows out of the US capitol.
It's attractive to ignore it because "reality has a well-known liberal bias". Politics are not created equal. Conservatives are observably less educated than liberals: look at the demographics.

That said, any bias (including corporate influence) is worse than an agnostic information reporting machine (which C-SPAN or the BBC approach best).
The point is that "just HTML+CSS" is not the recipe for performance. You get into the same nuance as any other technology: how you use HTML+CSS is the recipe for performance. In fact, his image in this blog post doesn't have `width` and `height` set, so had it been higher up on the page and part of the "Largest Contentful Paint", not sure we'd have a 100 here.

This is where frameworks can be really helpful, and I wouldn't dismiss them. It gets quite tedious to keep up with the new attributes, cross-browser and cross-platform differences, image optimization CDNs and so on :)
Truveris | NYC, US OR FULLY REMOTE (US) | Fulltime | www.truveris.com Truveris develops software that works to improve market access & affordability for prescription drugs. We are hiring for a number of roles in data & engineering including: software engineers (various levels of experience), Data Engineers, QA engineers, DevOps engineers and data scientists
Tech stack: Python (flask), AWS, Linux, Postgresql, FastAPI, React.js, spark...

Please apply on our website (https://jobs.lever.co/truveris) or email Kaitlin directly at kobrien@truveris.com
We'll be building a proximity chat system soon!
Thank you very much. So we are talking about doubling (or halving, depending what side you are looking from) the access times.
>My solution was to dump Apple laptops entirely (which I know a lot of people won't want to do)

I think several will trade their M1 laptops due to the memory, architecture limitations creeping up after long-term usage and realizing they're compromising their previous workflow's productivity benefits. The excellent performance (CPU/power) and surprisingly well built Rossetta 2 has overshadowed potential limitations with memory and IO in the reviews.

Lightning fast opening of apps is great, but it's not much use to people like me who don't close their apps at all! I keep at least 3 browsers(for different projects) with several dozen tabs(with hibernation), Note taking apps, IDE and a VM with a browser open in it. So what's important to me here is the memory, at least 32GB is bare minimum.
On 8.1.x?
According to http://www.globalrichlist.com/wealth you qualify as a global 1 percenter if your net wealth is >= $770,000. That makes you the 45,045,226th richest person on earth.
I disagree. Companies are at fault here. It's apple's job to test common use cases, such as sending emails through common 3rd party services. And it is googles job to send the files its users wish to send.
> Women outnumber men as graduates, in medicine, in law. What is the difference between those fields and IT?

I'm not sure about the UK but law and medicine in the US used affirmative action to address sexism in the profession.

There were class action lawsuits that required law firms, law schools, medical schools, and hospitals to accept women doctors and lawyers. After sexism was recognized as a problem law schools used affirmative action to admit gender-balanced classes and law firms hired equal numbers of men and women.

STEM subjects didn't have these interventions so it's unsurprising that sexism is more of an issue than in other fields.
Were you deliberately trying to link to the middle of your article? I think the '#62e3' at the end of the URL causes this.
Ah i see! Makes much more sense now :)
This is a good read about trademarks in a FOSS context: https://fossmarks.org/

But, yes, you can trademark open source software even if you aren't charging for it. (IANAL)
The Earth does not belong to us, rather we belong to the Earth. The Earth is more important than we are, we should put the Earth's needs ahead of our own needs. We must stand up for the rights of the Earth, or else human rights will be impossible to maintain.

Ecosocialism has never been tried, and it is now long past time. Stalin and Mao certainly didn't even try. And even if human communities are vivisected, so what? The Earth is more important.

The Earth is very much my religion and I stand by Her.
I'm fairly sure (not an economist or insider etc) that the generic / own brand products actually have the highest profit margins for the shop, because there's not a big external brand like Unilever that wants their share of things.
You need the right policies in place to direct resources accordingly; Freedom Dividend/UBI, Democracy Dollars, Journalist Dollars, Ranked Choice Voting or similar, etc.
"So many kids in my area have their days booked solid"

Sounds like a wealthy thing, not a Western thing.
I think it's genius. I'm glad scumbags like this is exist. They make our systems more robust.
Unless you're a psychologist:

https://en.wikipedia.org/wiki/Psychology#WEIRD_bias