jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
> It is a racemic compound with two stereoisomers, the (S)-(–)-isomer being five times as pharmacologically active as the (R)-(+)-isomer.[14]

I can't wait until 2041 when this is phased out and we get "esviloxazine" for $300+/month.
Not entirely so. See the counter at bottom left: “US Debt Held by Foreigners”. About 25% of the total. This is debt that can “come home” — as happened in the 70s:

https://en.wikipedia.org/wiki/Eurodollar
"Harry Potter and the methods of rationality" - affly known as HPMOR - https://www.hpmor.com/
For anyone curious about the proposed mechanism of action, care of the Wikipedia page https://en.wikipedia.org/wiki/Viloxazine

> Viloxazine, like imipramine, inhibited norepinephrine reuptake in the hearts of rats and mice; unlike imipramine, it did not block reuptake of norepinephrine in either the medullae or the hypothalami of rats. As for serotonin, while its reuptake inhibition was comparable to that of desipramine (i.e., very weak), viloxazine did potentiate serotonin-mediated brain functions in a manner similar to amitriptyline and imipramine, which are relatively potent inhibitors of serotonin reuptake.[11] Unlike any of the other drugs tested, it did not exhibit any anticholinergic effects.[11]

> More recent research has found that the mechanism of action of viloxazine may be more complex than previously assumed.[12] It appears to act as a potent antagonist of 5-HT2B receptors and as a potent agonist of 5-HT2C receptors.[12] These actions may be involved in its effectiveness for ADHD.[12]

> It has also been found to up-regulate GABAB receptors in the frontal cortex of rats.[13]

As always, a drug's effects cannot be interpreted simply by looking at binding affinities. It's important to focus on the actually human clinical trials. The binding affinities are interesting in the context of neuroscience and drug research, but less so for treatment decisions.
There we go, I opened this thread with two things in mind that immediately struck me - tab completion and pressing up for previous command and those two are the top comments!
The ADA doesn't require passengers to state that they have a service animal. Additionally, having that would likely open up Uber to additional liability for discrimination cases of people turning down rides (or marking that they have a dog allergy when they don't) and causing the rate or availability to be different for someone who has a situation that is covered by the ADA.
I had no issues quitting for a year and then explaining later that I was in a sabbatical period. Last time (3 years ago), I got a job offer 1.5x better than the one I quit for traveling. You only lose leverage if you need a job fast.
I find that talk really painful. I do not recommend it. It is mean spirited, full of misleading characterizations, and - I think - it misses the core point of functional programming. Gary Verhaegen's comment "this was a waste of time" addresses the many problems effectively. Brian Craft's "ugh" addresses others. Either of those comments are more worthwhile than the video itself.
The reason why the account managers change this way is because of so called territory or account realignment. These are sales terms but ultimately it means don't sit on one client for too long. Salesforce does this every single year, last week I received an email from 6th or 7th account manager since I started using them. The story is always the same: they get in touch,try to understand your business,ask questions,and see if they can spot something that previous guy missed. I hate it. However, this seems to be working on their end,as the sales keep growing...go figure.
The current way that (all?) farming works in India is that farmers take their produce to some (government run?) wholesaler and they get at least some government-mandated minimum price for their produce. Somehow this makes its way into the rest of the local and global economy. The new proposal is advertised as economic liberalisation of this system and involves scrapping the minimum price guarantee.

It is advertised as allowing more efficiency in the market and giving farmers the option to sell their produce to more discerning buyers at higher prices. Others worry that farmers will be worse off and won’t get such good prices, or may be exposed to more price risk (obviously it is unreasonable to tell these smallholders to sell futures and buy insurance against low yields). They suggest allowing farmers to choose who they sell to but still giving the option of getting a minimum price, but this would be terrible for whoever guarantees the min price due to adverse selection. The law’s proponents claim that this opposition is merely fear of any change.

I think there is also a general mistrust of the government and an expectation of corruption and that a big law might be secretly designed to benefit the lawmakers who implement it.
You don't stay ahead by spending way over yours means.

it is a key reason the Soviet union collapsed. They were trying match US spending in many sectors and capitalism can outspend communist economies any day.

Diverting spending from say infrastructure to miltary does not help a country in the long term.
Public transportation didn't succeed as much as it should have probably because a significant amount of people hate it.

Schedules, dirty environments, people uncomfortably close to each other during traffic hours, static dropoff locations.

We might get there with Uber-like carpods if autonomous driving ever succeeds.
I use coinbase as it was the easiest and least sketchy way to buy a couple of years ago. I feel though that a lot of the big gains for a particular coin are made before coinbase authorizes that coin for trade on their platform. Can anyone provide some insight/ ELI5 as to why the coin selection is curated vs a free for all?
Good for them. But am I the only one who finds it slightly ironic that the brainchild of distributed ledger tech and crypto currency capitalism is now filing for IPO in what is the hallmark of old capitalism (regulated markets)?
AMD was almost sinking till a few years ago, so throwing the little money they had in expensive pipe dreams like this would have been their end.

Best they stuck to their strengths like Ryzen CPUs and Radeon GPUs and turned the ship around.
This is a tale told by S.N. Goenka in the Vipassana meditation discourses. The whole story:

----

"Once a young professor had made a long journey by sailing. He got an excellent degree, but he had no real experience.

Also, there was an elderly, illiterate sailor on the same ship he was sailing in. Every day, the sailor will come to the professor and listen to his lecture on different subjects. The old sailor was intrigued by the young professor’s talk.

One day the sailor was about to leave after listening to the professor’s talk, then the professor said, “You old man, have you studied geology?” The old man responded, “No sir, I’ve never been to school or college, and I’ve never studied anything. What’s the geology?”.

The young professor answered, “In Geology we study about the earth. Elderly man, if you haven’t learned geology, you’ve wasted a quarter of your life.”

“If such an intelligent individual suggests so, it will be accurate that I’ve lost a quarter of my existence”, the old man thinks and leaves.

The next day after listening to the professor’s speech the sailor was about to leave, the young professor asked, “Reply me you old sailor, have you studied meteorology?”. The old man responded, “No sir, What’s the meteorology?”

The professor responded, “Meteorology is the science related to the wind; the study of the wind. Poor guy, you’ve wasted half of your career.”

“As this qualified young guy claims that I’ve wasted half of my life and has to be true”, the old man says to himself and leaves.

Again the next day, as the sailor was preparing to leave after listening to the professor’s speech, the professor inquired, “Tell me, old sailor, did you study oceanography?” The old man responded, “I already told you I have never been to school or college and studied nothing. What’s oceanography?”.

The young professor answered, “In Oceanography, we study about the ocean. Poor old man, you’ve wasted half of your career.”

“Half my life had to have been lost as this deeply educated young man says,” said the old man to himself and left.

Then the next day, the old sailor comes rushing to the young professor and calls out, “Professor Sir, have you learned swimology?”. “Swimology, what’s that?” the professor asked surprisingly.

I was questioning, “Can you swim, Sir?”. “No, I don’t know how to swim. Yet why is that?” the professor questions again.

“You young man, sir, can’t swim. The ship has hit a wide rock and is sinking. Those who can swim can swim to the nearby shore, but those who can’t swim may drown. I’m so sad, you’ve lost your whole life.”

----

Source: https://enlighteningsummary.com/swimology-story-of-learning-...
Depending on how the defer implementation looks like the same could be achieved with block-level defer by having the defer's "owner" (e.g. some object with RAII semantics) in the outer scope.
From Wikipedia:

"Terrorism is commonly defined as violent acts (or the threat of violent acts) intended to create fear (terror), perpetrated for a religious, political, or ideological goal, and which deliberately target or disregard the safety of non-combatants (e.g., neutral military personnel or civilians)."

This guy is a mass murdered, not a terrorist (in the usual sense of the word).
> maybe they have a segmentation strategy there

That's what I'm afraid of. I'd very much like to not have to pay 6k+ for a Mac Pro because ... I don't need one. But if they continue crippling the Mini I just might have to.
Maybe my comment was not clear, I do not specifically test the app and all its functionalities. I use the app myself on a daily basis anyway, which acts like a sort-of continuous integration testing program. I use the new version myself for a few days before publishing it, or provide it to some chosen beta testers that use the product anyway.
>>If the government will not act then a talent drain might be the next best thing.

Is it? While the NSA conducts unconstitutional mass surveillance and has played a huge role in eroding privacy, it also performs a lot of legitimate duties. I personally don't want the country's primary intelligence agency to be populated with a bunch of mediocre people.
Can anyone point to a good reference explaining what your rights are and what to do if questioned and/or detained by the TSA?
TSA does more than just airports

"With little fanfare, the agency best known for airport screenings has vastly expanded its reach to sporting events, music festivals, rodeos, highway weigh stations and train terminals."

http://www.nytimes.com/2013/08/06/us/tsa-expands-duties-beyo...
I work at Radius (http://radius.com/) and we've hired a few different bootcamp graduates from HackBright and HackReactor that we're very happy with. We've also turned down quite a few in the interview process though.

Also, my girlfriend teaches at Zipfian Academy (http://www.zipfianacademy.com/), a data science bootcamp, and so far they legitimately have a 100% placement rate. I'm sure they won't keep that up forever, but they do a great job preparing their students. Theirs is a little different, however, as they expect some prior programming and a fair amount of math, so it's fairly difficult to get into.
From your link:

> [...] at least in time for ITUNES to begin selling eMasters the earlier of a general release date, provided by COMPANY, or when any other distributor is permitted to begin selling, or making commercially available, COMPANY Content in any format.

It appears that her Bandcamp is hosted at her own domain, at http://music.zoekeating.com. Does that count as her distributing it herself, or as someone else distributing it? Except for the tiny footer saying "Bandcamp", it looks like self-distribution. In my relatively uninformed opinion, that seems like it means section 3a doesn't apply.
https://github.com/containernetworking/plugins/blob/master/p...
Is this a joke? I was searched by the TSA the last time I took Amtrak. They just plopped down a table in the middle of Penn Station and went to town.
Wow.

I downloaded the app, bought the Spanish -> English pack, and tried it with some simple phrases in a big TextEdit window on my monitor. It flickered a bit, but I expected that from a monitor. It got them right.

Big deal, common phrases are easy -- I could just buy a phrasebook. Then I tried a random phrase from the Spanish version of "Dive into Python":

Una función, como cualquier otra cosa en Python, es un objeto.

It flickered like before from the monitor, but it was easy to read the translation:

A function, as any other thing in Python, is a object.

Perfect? No. Usable? Absolutely.

As soon as a French -> English pack is released I'll buy it, even if it's $100.

This is the kind of thing that would make it possible for me to move to Montreal. I love that city, but don't know French. I could learn, but it would take time and I'd be lost like a baby gazelle on the Serengeti while I learned.

This app could ease the process of moving to an entirely different country. That's amazing.

Hello, future, it's nice to see you.
I wonder if Libya will take back the domain name if we save pr0n links.
Have you guy's explored at all how difficult mandarin translations will be? If it is possible this would be a huge market for you.
Ah, the 'no true terrorist' fallacy. Joking aside, there are many more idiots like Breivik, so there is a risk of future attacks.

But they're unlikely because the Norwegians kept their heads cool, didn't turn him into a martyr but showed him for what he is, a deranged sociopath.
I'm not sure about the internals of set(f), but the logically equivalent

s = set()
for x in f: s.add(x)

Does not read everything into memory - by using iterators, it only reads one line at a time.
It took me a second to grok that this is really mostly just an OSS Android app with some associated DNS servers you can optionally use with it. It's not in F-Droid yet (which I personally consider to be a hard requirement for this class of software) because it includes proprietary bits, but here's the link to the F-Droid issue for those who want to keep an eye on it:

https://gitlab.com/fdroid/rfp/-/issues/1552

In the meantime, there's DNS 66, which includes some similar features (minus the app firewall)

https://f-droid.org/en/packages/org.jak_linux.dns66/
Gates has dedicated his post-microsoft life to issues like climate change.

Would a 4 year undergraduate degree really make him more authoritive.
Yep we do! We started building custom but just went into app orchard
Speak for yourself. I make my $$$ selling saas tools to people who make tools for people who invest in tools for ad peddlers.
Nice memories, I keep trying to find Delphi soul in Java and .NET.
Hi HN.

Well, I wanted to make a 3D model and 3D print it, but I just didn't want to use OpenSCAD. So I ended up making a whole new 3D modeling library based on signed distance functions. I'm pretty happy with how it turned out so far, so I thought I would write a nice README and share it here.

It's certainly complete enough that you could try it out and make your own 3D models - let me know if you make anything interesting!
Relevant education or not he can afford to hire an army of scientists to solve problems for him. Thankfully he seems to care about fixing world problems and that's what he does. His announcements are based on the research and investigations carried out by his foundation which employs experts, they are not results of his own work.
Django without a doubt. It will handle ORM, frontend, backend, etc. It does the entire stack end to end and has built in migrations too, unlike Node. Please don't fall into the JS trap, it sucks. You can easily use django rest framework to redo the frontend with something like React later on without massive backend changes.
AFAIK you will need widevine support
I think people are responding to language like “wannabe-stasi deplatform mob” and “de-platforming witch hunt” more than the actual facts or websites involved.

That language is not neutral, so the response isn’t surprising.
I even do vertical farming in Minecraft.
> Does the Google Ads team use Dart on the server-side?

This, alas, falls under the "nothing to publicly announce" umbrella.

> The Dart blog post was unclear about the future of the Dart VM.

The VM team is still moving full speed ahead. In some ways, their job is easier now because they don't have to worry about the (considerable) complexity of integrating the VM into a very large application that already has another language VM, GC, very large set of API bindings (the DOM), etc.
In Portland protestors have clubbed police on the head with bats (and famously a wrench), tried to set the courthouse on fire, and tried to set the mayor's occupied apartment building on fire.

Attempted murder, and arson of occupied structures. Far worse than the capitol riot.

Also, who the violence was directed at. In DC most of the rioters were unarmed and fought with police. In Portland and LA many protestors were armed and fought passing citizens, attacked drivers, etc. Police don't "deserve" to be hit, but they sign up knowing that the job can get rough. Random old ladies protesting the vandalism of their building shouldn't be hit but the justice mobs feel free to hurt anyone.
I'm sure its a cool project.

But its not showing things directly, is it? Its interpreting a frequency and converting that to an image. Is it really that different to a music visualiser?
TBH, the jobs I held in the late 90's and early 2000's where I was a COBOL programmer were honestly some of the most challenging jobs I've had. There were large systems that nobody understood and hadn't touched. I was really surprised to find banks relying on systems that hadn't been touched in 10 years.

But let me ask. Would anyone hire me having 6 years COBOL experience from late 90's to early 2000's?
To move up, you often have to move out.

I'd cut my losses and move onto a different company, especially after your comment:

> although I could probably get 50% more without much effort at other places.

Unless you're perfectly happy with your job and your pay (it doesn't sound like you are) I'd start looking. If you can find more intellectually stimulating work elsewhere at better pay, that seems like a win-win.
The text of the LGPL relies on the text of the GPL.
> A British trial called Recovery has provided important information about older drugs, finding that hydroxychloroquine did not help hospitalized covid-19 patients, while the steroid dexamethasone could be a lifesaver. But the United States has lagged behind in conducting such trials because of the fragmentation of the health-care system and the lack of financial incentive for pharmaceutical companies to continue to do research on old, cheap drugs.

Good to know that financial incentives are the primary determinant around which trials are getting funded. Puts a different spin on things when people say repurposed drugs shouldn't be used because "there isn't enough evidence they help."
"The whole point of vaccination campaigns is to get the whole population vaccinated to eradicate the breeding ground of the disease."

That's not entirely true either. You seem to have a habit of telling half-truths to further your own belief. You don't need the entire population to be vaccinated. Many vaccines do rely on herd immunity, but that number isn't 100%. Many fall around 85%, give or take 10%. There are also vaccines given to only very specific people - rabies for animal handlers, post exposure vaccination for rabies, smallpox for the military, etc. Many vaccines aren't able to eradicate illnesses because they are endemic in other hosts of the environment (rabies, lyme, etc).

"Guess, why we managed only to eradicate the first, and what stops us from doing so with the others."

It's specific to each one. Again, many of these illnesses have endemic sources other than people. It's an extremely complicated topic, yet you seem to be some self-proclaimed expert operating with a 5th grade understanding.

"More time can benefit the virus to try more different mutations."

Sure, pathogens mutate. There are going to be new pathogens in the future too. At this point covid is now endemic throughout the world. It isn't going anywhere, even if we vaccinate everyone. I might add that vaccinating everyone isn't even possible due to age and medical condition guidelines.

"I don't think you are speaking for the benefit of the researchers here."

Just an unsubstantiated claim now? Even the researchers have stated that there is still a lot to learn and more studies will take place over the years. If people find out that one of the vaccines shows a correlation with a rare blood disorder (as is currently developing), don't you think people should be informed about that so they can choose which vaccine to get?
It's about solving every problem in due time.

Starting with an easily scalable infrastructure, if the need for a scalable infrastructure is either unproven or distant, is not the best use current resources. It's more cost-effective and beneficial to use an out-of-the-box tool like Heroku and spend our time building the product that people will actually be paying for.

There might come a time where the hosting costs on Heroku are getting frighteningly high, but even then it's something that might not be high priority. If the profit impact of building and maintain a K8 infrastructure is less than the profit impact of building a new feature and securing more users, then by all means, let's continue paying Heroku and focus on what makes the business more sustainable.

The time to convert from a simple setup like Heroku to a scalable system like K8 is when that change has the biggest net impact on the company's operation.
No that's jobboardjobjobboard, because it's a jobboard for a jobboard job on this site.

jobboardjobboardjobboard is a jobboard for jobs at sites not just limited to this jobboard, but all aggregation jobboard sites.
Alright so, I like these websites, because they are great. But a lot of people take their existence as a reason to shit on modern website development and say asinine shit like "all these websites are slow because they use react/vue/angular/whatever" so I registered modernfuckingwebsite.com to show that using modern build systems, modern tools, and all the hotness you can produce a fast, lightweight website that is just as "great" as these, completely negating their whole view of modern tools.

But I haven't had the time to put into it.
We live in the era of CSS3, embeddable web fonts, & the text-shadow property, yet this is what represents IE 9’s support for web typography: http://jsdo.it/event/svggirl/img/movie/img_loading_01_en.png

If you’re going to resort to raster graphics at least do a better job hanging that apostrophe in the word “it’s”.
If you are using only the open source edition of VirtualBox, kvm can do a reasonable job. I run Windows 7 on it in headless mode with VNC - primarily I need it for the presentations, everything else I do from Linux.

My perception was that it is a bit lighter than VirtualBox, and it worked very well so far for me. VBox had a couple of glitches when I was using it before.
The RSIZ for an instance of `node' running on OS X 10.6 after banging at the keyboard for a while, but doing nothing of note, is about 12M. The RSHRD is about 4M.

The numbers are nearly identical for a small-but-not-trivial Node.js-based web server I wrote that accepts requests and talks talks with Redis.
I know you're being sarcastic, but this is actually a good idea for a gamification app. And people are starting to already do this
I get the header/footer and a "log in with Facebook" button--you might want to add some boiler plate description too. :)
You are right! Others noted that mistake as well.