jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
Yes. Synthetic antibodies are a thing, but they are very expensive and very hard to produce (from what I inderstand).

Using animals when possible (for example horses, for the production of snake venom antidotes) seems more efficient in cost, volume and time.

Take for instance this crisis. They just need the plasma of immune individuals to give temporary immunity to sick or at risk individuals. It doesn’t scale but it works.

Some good basic reads:

Antigens - https://en.m.wikipedia.org/wiki/Antigen

Humoral Inmunity -https://en.m.wikipedia.org/wiki/Humoral_immunity

Synthetic antibodies -https://en.m.wikipedia.org/wiki/Synthetic_antibody

Antibodies memetic - https://en.m.wikipedia.org/wiki/Antibody_mimetic
Wow. It's not? That's crazy... it's all custom?
Quantifying the difference between a language and a dialect is always going to be a problem. English dialects differ, but most English speakers also know well a standard variety of American or Commonwealth stock (which are mutually intelligible).

Distangling the Chinese languages is another huge problem, since the government of China sees them as all dialects of a single language, but any real comparison of phonology, syntax, or lexicon shows them to be quite distinct indeed.

My understanding is the syntax of Hindi and Urdu are very similar, but the lexicon is quite distinct. Since each has either a relatively more a Persianized or Sanskritized vocabulary.
I was fortunate enough to see him perform twice in Boston. Once at Symphony Hall with Di Meola and McLaughlin, and once at the Orpheum with the dancers and everything. He was to his instrument what Tesla was to electricity. He made it come alive in a way that no one else could imagine.

I can't count the hours I've listened to his records while coding. It seems to induce a unique state of inspired concentration unlike anything else.

https://www.youtube.com/watch?v=_fl8RBIr_WY

Goodbye Paco.
Well compiling it from sources is not THAT hard.

git clone git://github.com/mono/mono.git
cd mono
./autogen.sh
make
sudo make install
http://nexmo.com has pretty decent coverage
I think I have a fairly good understanding of self (I don't meditate.) I'm INFP and fairly introverted and inward-looking. I don't generally feel lonely, but small attention-span is definitely a problem I face (with the symptoms being the same as OP's).
si != nyc ;)

Jokes aside, I'm in a Crown Heights 1br for < $,1200
It's not necessarily a huge burden, but if someone wants to run 10K URLs through this thing on a daily basis we'd need to have a chat. As of today it's not ready to scale that big.

Of course, if someone did want to run that many through I'm sure we could talk about volume pricing, given sufficient lead time to scale the app.
Yeah, you have to make a leap that's not explained in the puzzle. An intermediate machine or some other method has to be used to keep the secret a secret, yet the answer can be "public".
Could somebody explain to me this community's fervent objection to advertising? It seems so out of sync with (y)our usual socially liberal / libertarian capitalist standpoint.
I have a Nissan Leaf so yes, there is no fake engine sound, only a sound in front at low speed to warn pedestrians.

Not only I would not want a fake engine sound but I would be willing to pay more to have my car sound proof, with insulation or something, it would be quieter, colder in the summer and warmer in the winter.
Yes, came back here to correct my comment. They're using the requestFileSystem. http://caniuse.com/#feat=filesystem
I'm suspicious of libraries who showcase their size as a reason to go with them.

Its the motion of the ocean in the library that matters.
>Olivetti tried to get into computers, and even had a good-looking IBM PC clone. The nice design didn't help.

The M24 [1] worked well too. It had a good display, particularly with the black and white monitor. An OEM Logitech mouse could be plugged into the keyboard.

[1] https://en.wikipedia.org/wiki/Olivetti_M24
Well, physics education definitely spoils Gravity somewhat. They tried to do bunch of stuff in realistic manner and crossed into "uncanny valley" of movie realism. During the movie I was "why medical doctor is servicing Hubble?", "no, you are not going to see it coming", "no, don't remove helmet when there is fire in the cabin!"

And, more importantly, "all three of them on the same orbit sequentially if they can go from one to another?". Basically movie implies that. Of course the question is how they got Hubble on the same orbit, since they where servicing it, by theoretically it could have been repositioned during previous missions.
The subtext of BADA55 is that even curves that are seeded from mathematical constants or from other first-principals rationales still provide a malicious curve generator with leeway to pick from many potential curves, and to steer victims to the weakest of them.
At no point was enhancing the US’ end-to-end ability to manufacture modern semiconductors at scale a Republican issue - the closest it got was “China is bad” and a few poorly placed sanctions. This action attacks the problem from opposite side.
Thing is, in the ‘olden days’, the only thing you could do with a home computer was tinker - the job of a computer was to be a computer but little else. And the number of people interested in doing that was small.

Today, the job of a computer is everything. Computers are in everything and do everything. They are our interface to the world. Their value is what they enable - writing, tax returns, video consumption, gaming and everything else, not the fact they’re a ‘computer’.

For those of us who want a computer to tinker with, we’ve never had it so good. There’s so many more options than there’s ever been for hackable tech. Just because most people don’t want to do that doesn’t mean they’re wrong, it just means they have different priorities.

I love the fact I don’t have to muck about with my iPhone to get it to work just as much as I love mucking about with my raspberry pi to get it to work.
What is the point of DigitalOcean, Linode etc, when one can use the more reliable big cloud providers GCP/AWS/Azure.

I don't think DO's offerings are strong enough to compete with the big players long term, especially in production.

Seems like an exit for a later acquisition by a bigger company, like Slack with Salesforce.
Housing cooperatives are very common in cities and are an attempt at breaking this cycle; you don't own your home, but a share in the apartment block. Because it is not operated for profit, the rent is so low that you can afford to accumulate and invest your capital in other ways (such as creating a business).
Do we have the public reporting to know how many bitcoin are currently owned (or maybe owed is a better verb)?

That is, can we add up all of the Bitcoin listed in the customer ledgers of all of the exchanges, or is that information (the total, not the individual entries) not available to auditors?
To be clear, ADA doesn't have a smart contract platform yet. I believe that's part of the update that is coming in a couple of days. They've been building towards that for several years and have done a lot of great work in the space.

Tezos is quite a bit ahead of ADA in that particular respect as they have smart contracts already.

I don't believe ETH2 will ever show up, but who knows.

Full disclosure, I've got holdings in both ADA and XTZ.
It was too early for that at the time, unfortunately. p-code was an attempt at making it machine independent (but maybe a serialisation / s-expression would have done better), but the performance loss was too great for it to get wide traction.

Interestingly, one of Wirth's PhD students, Michael Franz, wrote his dissertation on Semantic Dictionary Encoding, a method that was reminiscent of lempel-ziv encoding an intermediate representation in a way that let the de-compressor / code-generator re-use templated generated code. Unfortunately at that point Java was underway (Franz thesis was published in '94) and Franz moved on to work on various code generation and verification for Java [I think, I haven't followed his newer work that closely]

But it doesn't end there. One of Franz' PhD students at UC Irvine was Andreas Gal, who did his thesis on tracing just-in-time compilation and went on to do TraceMonkey, and became CTO of Mozilla.

[I still think there's interesting stuff to be done with Franz' SDE work; I've periodically looked at it ever since I read it first time in '94, but have never had the time to devote to it, and keep hoping someone else will revisit it]
Oh, that reminds me of the old days at universit. When someone forgot to log out we'd do something. Like writing a script to find a random picture and set that as X background, and running that in the background in .profile.

I wonder how simple it is to disable "simple mode" if any fun-loving visitors have enabled it?
DinglePharb? Are you fucking kidding me? Anyone who believes that a company named DINGLEPHARB is successful deserves to be conned. Further proof that a fool and his money are easily separated.
That's 4 cores running at 2Ghz each. I agree that the 8Ghz notation is quite confusing.
Anecdotally and simply observed over the years, individuals seem to be very defensive about what they choose to spend their money on, but how defensive they are decreases as their income increases. Houses. Colleges. Cars. Big-ticket electronic items.

I'm curious, does anyone have any interesting material or studies that have looked into this phenomenon?
"And doing "something useful" while commuting... Well ain't there a sure sign for disaster?"

Podcasts and Audiobooks. You can learn new things, keep on on recent events, or, even better, just enjoy the time with a good book. You can do this while driving even, without problems.

The only downside is you tend to not mind the traffic during the commute.
Yea, it's true - not an apple to apples comparison, but still: Ruby for the 'duino!
Not sure how easy it is to do.

But surely, as the "webapp" you can also revoke a users subscription.

I have been thinking about "recurring payment" with an agreed, "we the webapp" will cancel your paid access if you have been absent of the site "x days" or more likely 2 months.
The banned uber-powerful picture frame iPhoneOS app is in this space. Forgot the name.
Another "defense in depth" step would be to move your router off of 192.168.1.1. I recall seeing some browse-to-evil-webpage based attacks a while ago, and if the evil webpage can't guess your router IP (and it's not like it has access to your TCP settings in general) that can't work.

Obviously, just like moving SSH off of 22, this isn't a real defense, but it'll make it that much harder.
I can't believe people aren't tearing this asshole to threads. Between all the bullshit in his article, what he's really saying is this: let's pay less for health insurance by transferring more costs to the individual. I suppose you might support this if you're so deluded as to think lots of people are going to the doctors office because they're bored and have nothing better to do than have time consuming, often humiliating, uncomfortable to painful procedures and tests performed on them on a schedule that's extremely inconvenient. OTOH, those of us whose heads aren't firmly buried up our assholes think that people mostly try hard not to go to the doctor or hospital because the experience sucks, and so the way this Dave asshole is trying to save money is by discouraging you from getting health care you need by making it cost more.

ps -- people who don't straightforwardly acknowledge that health insurance isn't insurance, it's group cost pooling, are idiots who should be ignored in the health care debate. It's not insurance and shouldn't be because we can tell that in certain cases people will cost a lot of money to treat. Insurance would leave them out in the cold. Societies with integrity or conscience treat people anyway. Compare to insurance -- if you build a house in a flood zone on the florida cost, you should probably be told hell no -- no company will sell you insurance. If all the women in your family get breast cancer, we should still give you health insurance for when you get breast cancer.
>- Are you servicing a specific region
Southern California.

>- Who are your primary customers going to be? You say mechanics, but are they the only customers possible?

Mechanics, other people who will buy from me to distribute.

>- Does it have to be something with "Auto Supplies" in it? Think of successful sites whose names don't have anything in common with the actual purpose of the site (Google, Yahoo, Zillow...)

Not at all, any recommendations are helpful and highly appreciated. That's just what I was thinking..

>Maybe use your own name to cater to the customer segment that goes for the ol' folksy crap

I don't have a cool name that people with associate with. :(
The whole point of the page and the plugin is the annoying dancing raptor head.
Taking someones idea for a business and plagiarism are very different things
The UK is not a single jurisdiction. Scotland has a separate legal system from England and Wales, based on different principles; while most legislation has run in parallel since the Act of Union, English libel law doesn't apply in Scotland -- instead we have a defamation law:

"Under English law ... In the case of libel (the recorded statement), the victim can win damages even if he has not suffered financial loss as a result of the statement ... In a Scottish action, it is necessary to show that some harm has been caused" (Source: http://www.out-law.com/page-5624 -- my emphasis).

This is good news for me personally because my blog sits on a colo box in Scotland. (And when was the last time you heard of a libel tourist suing someone in a Scottish court? Riiight ...)
> we take whatever measures we have to to get rid of it for the greater good of society

Justifying around the "greater good" is so obviously fraught and subjective.

And since the workers in tech are overwhelmingly liberal, they will undoubtedly bias policies of mass communication platforms to disallow opposition.

Oddly enough people so concerned with minority representation will steam-roll minorities when they make blind "greater good" majoritarianism the norm.

And nowadays the definition of "harm" has been trivialized so far that really practically anything is a target.
Yes, the problem is this; I’m not interested in what someone who is dumb enough to storm the Capitol building has to say. And they aren’t interested in having a debate on the facts either, so what are we going to discuss? I don’t get how we can come together and make this better...
I'm not going to argue about which other demonstrations have "burned down cities", nor about whether everyone is OK with violent protests.

But yes, there is a large and qualitative difference between a riot with property damage and attempting a full on coup d'etat. The latter is a crime against the very heart of society.

To be clear, if the Trump supporters had stood outside Capitol and protested, even violently, it would not have been such a momentuous thing. Crossing the Rubicon indeed.
The left wing is really spurring on the new US civil war that they seem to want so much. I hope they don't succeed.
I don't think intent matters as much as you think, because the government millitary complex can force you to give that info in the first place and then use it for very bad purposes, like china and USA has repeatedly. Gathering such info while being aware of such realities and very wealthy is pretty bad too.
Why is everyone writing as if John L. Lewis were about to bring American industry to a halt? I've heard numbers for the Google union members around 300, which might amount to a decent bargaining unit for the faculty of a community college, for Alphabet not so much. Sometimes the proverbial "cloud no larger than a man's hand" signals a change of the climate; more often it breaks up and disappears.
They’re being de-platformed for the same reason the Marriott kicks a homeless person out of the lobby or Amtrak kicks a loud person out of the quiet car: most of the platform’s users don’t want them there.
Is it my phone or Apple's phone?

Shouldn't Apple also install an undelete-able web proxy on my iMac so that I can't access 'dangerous' websites?
It’s pretty simple, really.

“I hate Bob” is fine.

“Bob should die” isn’t.

Some tweets don’t need to exist because it might lead Bob to be killed, especially when said by someone with a cult-like following.
> the reverse engineered version of GTA III and Vice City

Ohhh. Thank you for telling me about this. I just found a mirror and successfully built it for macOS. Runs so much better than the wine version. But I guess I'll never finish that RC helicopter mission anyway lol
Well but that's a bit like saying that since there are technically races in GTA it's also the most successful racing game. It will also be the most successful flying game and the most successful sailing simulator....etc etc.

I don't know, even though there is shooting in GTA I don't think I'd call it a shooter.
This sounds like a good problem to solve.
Give me your address, and if someone asks, and you are ok with, i can verify you live in said (country/county/city) but not tell the exact location.

Obviously, there is a problem of trust in the first place to solve, but i fee like this sort of data escrow could be useful to a lot of people.
What bearing does this thought experiment have on our reality, where Nazi race science is completely false and discredited?
If I remember correctly it is a restriction of JVM. That's why Scala also needs a special annotation for TCO.
That may be true but it doesn’t change the story. A user was ripped off by an app hosted by Apple. They then visited a location owned and operated by Apple which claims to give support. And then didn’t receive support.

It’s not on the user to know the internal management of the company
They're effectively giving them a price below the going market rate though, and they can choose to raise that price any time. It would be more messed up for the govt to step in and insist they need to continue selling at their arbitrary MSRP well below the resale value, though I suppose anything is possible.
> Token-ring networks could have ruled the world.

Unlikely. People forget that a star topology (Token Ring with MAU--the MAU was ferociously expensive) was expensive in that day and age--both in terms of technology (lots more VLSI) and infrastructure (everything was mostly wired up with RJ-11/shitty wiring for voice and nobody had RJ45/Cat5).

Ethernet installations evolved from coax to hubs to switches as the price came down.

Yes, eventually star topology won, but it got there in steps--and Token Ring couldn't do that.
Manara's Polish-American co-founder catching up late here to say I never tried that ice cream, but I do recommend eating knafeh in the West Bank and fattet hummus in Gaza! The food in in West Bank vs Gaza is quite different... I think Gaza is particularly good... but unfortunately it's almost impossible to get there unless you're a humanitarian worker or a journalist.

NOTE: if you work in tech and want to mentor in Palestine, check out Gaza Sky Geeks and Code for Palestine. They organize on-site travel for select volunteers (full transparency: I'm involved with both organizations)
Since you passed the bar at repl.it too, after your google internship you could get back in touch with repl.it and tell them you are now more experienced and still want an internship, they might just add you for the next summer.

I have to add, your story is heartwarming and I hope other people who aren't so fortunate will be able to learn and get more opportunity and achieve like you have.
Most the weak players leave for Texas and Seattle. Anyone who loves being in Silicon Valley won’t leave here. The weather is better than both places and the political climate is better.
so ... anyone have a floating-point library for sed(1)?

(this is a serious question. compare:
http://sed.sourceforge.net/grabbag/tutorials/lookup_tables.t...
and
https://en.wikipedia.org/wiki/IBM_1620#Transferred_to_San_Jo... )
Microsoft had all day interviews back in the 90s. It’s more efficient for both parties and has been for decades.
Ah I see. My main issue is say you get to 10m then they have to invest 10m but what if you don’t need the money? Or is it more about their skin in the game?

What if you only do 500k but strategically you could do with 10m because of a pivot? But now you’ve given away the equity so it’s harder to raise?
Or the eight-year-old "can't import certificates into mobile Firefox" which makes the browser unusuable in several contexts:

https://bugzilla.mozilla.org/show_bug.cgi?id=868370
Yeah, Amazon is a massive target for hackers, but hasn’t had any particularly bad breaches that I can remember. I’m sure their security/privacy is far from perfect, but it seems to be pretty effective.

FWIW I’ve never worked for Amazon, but I have quite a few friends and former coworkers at AWS. We’ve had discussions about security and privacy, and the general sense I got from them is that Amazon has more of a focus on security and privacy than any tech company they’ve previously worked for.
Intolerant against red states and/or Republicans?
Maybe they didn't know about the ideal gas law. It seems like very few other people do. Maybe they did know about the ideal gas law and took advantage of it. In any case, they followed all the rules "to the letter", at least if you believe they did what they said they did. Most people say that when you follow all the rules, you are not "cheating".
An inexpensive wrapbootstrap theme is the way to go, I think.
Only 26 words down is this link: http://www.nytimes.com/2014/09/16/sports/for-longsword-a-com...
Armor (tanks) and other forms of mechanized infantry contributed more to the end of trench warfare than airplanes.
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You are absolutely correct. However, at that point it becomes an ethics issue. If these are financially motivated search results without disclosure then it becomes a whole different ball of wax. If they are deliberately screwing up their relevancy algorithm in the name of a bottom line then people need to know that.