jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
I don't think that's ever the case actually. It's just that the immunity conveyed by an active infection often is as good or better than what a vaccine would produce so there's no reason to apply the vaccine after an initial immune response. But just like some vaccines, after an infection you may need a booster later to maintain immunity.

Though for this specific vaccine the question is somewhat irrelevant. In this case, they are introducing an antigen that the underlying condition, MS would never cause to occur. This antigen activates regulatory cells which then supress the immune systems production of myelin targeting antibodies.

So in the case eof a normal vaccine, regardless of whether it is mRNA or not, the vaccine is conveying information to the immune system that you might also acquire through an active infection.

This vaccine however is conveying information to your immune system that no active infection would convey.

This all kind of answers my own question which would seem to be yes. As long as they can find an autoantigen that will stimulate regulatory cells which supress the problematic autoantibody producing immune cells. At least that is my read after mucking through the medical jargon.
I hope this answers your questions:

1. I want to move the money around so I don't spend it and I know I have enough to pay my bills. I don't want to see $1,000 and think "I'm going to spend that". Similarly, I don't want to see a charge come through for a bunch of bills that I don't have enough money for.

2. In Simple's app, if you overspend in an expense or goal, it takes it out of your "safe-to-spend" amount (think: your total spending money). It notifies you that you "overspent" so you can move money around in your little envelopes to fix it.

3. In Simple's case, you have one literal checking and up to two literal savings accounts. The expense/goal "envelopes" are virtual buckets in the checking account, not actual accounts with account/routing numbers. In the past, I've used many literal checking/savings accounts for this purpose.
GitHub Enterprise is pretty pricey. It's almost exclusively about being able to host internally.
I am guessing this is being said in a joking manner.
Well, seeing it from a positive perspective, I did (finally) get the password changed on some sites =)
Never been great at keeping correlation and causation separate, but maybe you should muscle up instead?

http://physbam.stanford.edu/~fedkiw/photos/bodybuilding_arms...
I see these sorts of "just do it" comments all the time on HN, but short of becoming some cold calling Glengarry Glen Ross-type, it's not at all clear to me how one goes from being an employee programmer to a one-man, bespoke software shop.
Again, emphasis on "need not necessarily". Text adventures are a subset of interactive fiction.
That was my first "wtf" reaction. Although they don't show it in the photos, the back of a mac mini isn't exactly a fun place to have to poke around all the time. Cables etc. Especially because (at least in older models) the cables tended to get loose after a year or so and could be easily knocked out. I wouldn't want to be reaching around there to pop the card in/out. It also limits the places you can mount the computer relative to where you're using it from. Seems stupid. They should've left it out. However, I guess it provides a good utility for doing occasional tech support (boot from SD etc).
So in order to have dual monitors on this new design one would have to have both a miniport to DVI and a HDMI to DVI adapter I take it?
I disagree. Its too expensive as a TV only box, and thats a market that is still very new and small. People (well everyone I know who has one) look at this as an entry level Apple desktop machine.
If we move, in or near a big city is about as clear as I can be at this stage.
Good point, though do you develop a well balanced individual that way?
I am well aware of that, I am simply forever amused the way they dig ancient skeletons out of the closet during the running.
Thank you all for your responses. Some of it feels like I'm trying to understand a foreign language, but I've got enough information to start making some calculations.

Thanks again HN.
I'm surprised Duplicity hasn't had a mention. It supports full and incremental, zipped encrypted backups (using GPG) to S3/SCP/FTP/local/etc. Under the hood it uses librsync for fast binary diffs.

Duplicity + S3 is somewhat similar to tarsnap. It's not quite as friendly - you have to put a bit more effort in - it doesn't provide easy key generation, and it doesn't support snapshots, but you have no reliance on any third party service other than S3.

If the Duplicity software disappeared off the planet you could still recover your files - it's just split gzipped encrypted files.

Oh, and you can install it on OSX using homebrew: `brew install duplicity`

http://duplicity.nongnu.org/ (unfortunately the site seems to be down for me right now - here's the cache: http://webcache.googleusercontent.com/search?q=cache:2s6jQju... )
In Germany, mail-order companies are required by law to offer 14 days money-back service. There are exceptions for among others, perishable goods and custom-made goods.

The mandatory six-month warranty for defects, however, is independent from the money-back guarantee.
> If that's not true, if apps legitimately depend on
> specific revisions of the library code (because its
> authors are not maintaining backwards compatibility),
> those library builds need different names so they can
> coexist in the filesystem and dependent apps can name
> the one they need.

Yes that's now RPM/DPKG did it so far, but it's nowhere near as flexible as proper built-in support for multiple versions. What if your app/library depends on exactly version 1.2.3 of libfoobar? What if another app/library depends on all versions >= 1.2.4 and < 1.3.0? You can easily specify that with RubyGems but it's hard to automatically support this in DPKG/RPM. It forces the DPKG/RPM packager to either impose arbitrary restrictions on what versions are packaged (and thus restricting which apps are installable) or to work around it in a stupid way by creating multiple packages, libfoobar1-2-3, libfoobar-1-2-5, libfoobar-2-0-0. If libfoobar 1.2.6 is released the packager has to manually rename libfoobar-1-2-5 to libfoobar-1-2-6 and manually rename the dependency names for packages that depended in foobar >= 1.2.4 && < 1.3.0.

This becomes messy and tiresome very quickly. Aren't computers supposed to help humans?

> Because they each have far less work to do than the growing number of spur-of-the-moment integration targets that rpm and dpkg would face. It deters them from requiring features which rpm and dpkg don't have, and which they aren't prepared to implement in a way that every sysadmin everywhere is willing to rely on. And it's they who are creating the problem.

I don't see how sysadmins would reject proper support for multiple versions. They aren't losing any control over their system or any clarity.

> How useful would it be to auto-detect random crap that's been smuggled onto one particular production box behind everyone's backs?

Very useful because if those "random crap" exist then that means the sysadmin has knowingly installed them and wants to use them for a reason. You're basically saying "no user, this is what you want but I'm not going to allow it". I can't count the number of times where the user wants to upgrade libxyz to version 2.3.5, but the OS only packages 2.3.4, so the user resorts to installing from source only to find out that RPM/DPKG dependenceis don't like that. The user usually ends up uninstalling all those RPM/DPKG packages and ends up installing those things from source as well.
Taking a break and having fun isn't a "loser thing to do", it's good for you.
#bantown definitely no longer exists.
+1, https://www.dropbox.com/forgot is a password reset link.

Besides, there is much more to cryptography and building a secured system than just using that crypto suit or another (e.g. AES256-HMAC-SHA256 etc.)
> I've been thinking of forcing myself to spend half an hour each day without stimulus, just thinking and writing on a paper notepad to get around this.

This is good. If you find a cafe with the right ambiance for you, that's a great way of doing it. Then you make that place your "thinking cafe" - I travel a lot, and that's one of the first things I look for if I'm getting stuck or distracted at my apartment or hotel. Change of environment, for whatever reason, changes my thinking quite a lot. It's trial and error to find the right sort of environment for your thinking, but very useful when you find it.
With your close historic perspective, what do you think of SIMD and CUDA?
I have been reading this since yesterday. Can you shed some light on how can you include jQuery plugins with VDOM support. Ractivejs [1] does it using decorators feature.

[1] http://stackoverflow.com/questions/23083841/ractivejs-and-jq...
"Hey Nim, 2014 called... they want their language features back."

I jest.

But seriously, D, Rust, and C++14 are about as familiar to me as Nim.
Thankfully, the USA still has a fair amount of really strong legal protection from the bill of rights (1st-10th amendments). The 5th amendment protects US citizens from being forced to reveal their encryption keys.

Forced key disclosure with sentencing for failure to disclose (like in the UK) is particularly odious. If I have a hard drive full of random data, the UK government can imprison me for up to five years just by accusing me of terrorism or child pornography possession and demanding that I turn over the key to the hard drive. They don't have to prove that I did what they're accusing me of, or that I even have a key.
What happens when mum want's to meet him/her?
It's already much more powerful than many impotent governments of tiny countries. As its power grows, the number of governments it challenges increases.
Some time in August I made a count and realized that I had twelve active side-projects. No wonder I felt like I wasn't getting anywhere. I had a hard time just cancelling any of them, so instead I decided to keep going and let the list shrink as I finished things by refusing to take on anything new for a while. Now I am down to three active projects (a piece of software, a series of clothing designs, and an electronic device). This covers a broad enough range of activities that I have something to do no matter what kind of mood I'm in.
Thanks! Check out Jason's work designing the UI here: http://shipordie.com/post/1670651184/first-iterations-the-ne... and let us know if you have any feedback. We'll be getting a bunch of solid data from real students soon as they use the interface in an upcoming school pilot.
so I have 2 that I work on daily (http://tweetsaver.com and http://floxee.com) that are not my primary business but I have probably about 10 that I rarely work on. Of those 10 there are probably 2 that I think could be big deals at some point in the future and the other 8 I probably should abandon :-)
Interesting obesity epidemic might be related to disease, specifically: https://secure.wikimedia.org/wikipedia/en/wiki/Adenovirus_se...
Isn't Intel having another go at it by acquiring Infineon?

http://www.mobilecrunch.com/2010/08/30/intel-acquires-infine...
Cool product! I would totally use this for organizing my wardrobe.
Looks delicious. Seems there's a place in SF that makes it: https://kokkari.com
Ah pipes. Thanks for the memories of a product that both came and went before it’s time. And technologically an amazing frontend web app. There is an attempt to remake pipes https://pipes.digital
Now that your <table> element has the class "sortable," what are you going to do to actually make it sortable?
One can read that as "The minimum wage isn't doing its job anymore and needs to be increased."
This looks very interesting indeed. I am currently working on a system that allows hierarchical system modeling and evaluation of so-called "observable process models". I can easily understand leveraging something like this over HTTP to reduce implementation details of model and state transfers.
So a reimplementation of celtk or hoplon?
The Book of Shaders is half vaporware, or am I missing something?
Strongly held beliefs are perfectly fine. Presenting opinions (or information derived from reading of minds or the future) as fact, is not - in my personal opinion that is, my opinion is clearly not shared by all others on HN. Perhaps the ends do justify the means.
> Sites generally supportive of India, Venezuela, Russia, the Irish minority(/majority) in north Ireland, China etc. are not OK.

I can't square that these ratings from Wikipedia:

- The Hindu: trustworthy. There is consensus that The Hindu is generally reliable and should be treated as a newspaper of record.

- Al Jazeera: trustworthy. Al Jazeera is considered a generally reliable news organization.

- The Indian Express: trusted. The Indian Express is considered generally reliable under the news organizations guideline.

- The South China Morning Post: trusted. The South China Morning Post is widely considered to be the English-language newspaper of record in Hong Kong.

- Xinhua News Agency: no consensus. Xinhua News Agency is the official state-run press agency of the People's Republic of China. There is consensus that Xinhua is generally reliable for factual reporting except in areas where the government of China may have a reason to use it for propaganda or disinformation. Xinhua is also generally reliable for the views and positions of the Chinese government and its officials. For subjects where the Chinese government may be a stakeholder, the consensus is almost unanimous that Xinhua cannot be trusted to cover them accurately and dispassionately; some editors favour outright deprecation because of its lack of editorial independence.
I had to move four pages into the comment thread to find this salient point. Once obvious infrastructure providers talk of getting involved in censorship, things get scary.
David Ricardo didn't live to see cars and two hour commutes.
Take a look at LyX.
Great to see the IPython notebook being used by languages other than Python!

I've been wanting to read The Haskell School of Music[1]. I'm hopeful this would be a useful environment for working through it.

[1] http://haskell.cs.yale.edu/euterpea/haskell-school-of-music/
On the one hand, we do seem to be headed into a pretty fragmented market. On the other hand, if you're willing to cut the cord or at least switch to a bare-bones cable subscription with just the basic channels and no HD, that leaves you with a pretty sizable budget for streaming services and content purchases compared to a typical expanded channel lineup cable subscription. Of course that may mean limited access to certain types of content--live broadcasts in particular--especially if you don't get OTA. And it makes for a rather fragmented user experience. But it will probably actually be cheaper than a standard cable subscription, at least for now.

I'm very close to doing this but then I watch very little sports or other live events.
Former Facebook corporate lawyer Spencer Gusick, now a resident of Portland, Oregon, principal of Arlenbach Legal, was named as the perpetrator of second degree sexual abuse, a felony in the state of Oregon. The allegations, together with a full transcript and digital recording of Gusick’s confession, were disclosed on Saturday, April 2 by a pseudonymous blogger. Read more at rosecheval.wordpress.com. Trigger warning: the transcript contains graphic language.
When you're best in class you can afford to be proprietary.

Clark & Parsia had a history of open source (eg. Pellet) which was the best in-memory reasoner for a long time IMO... but not a lot of luck getting sustainable business subscription revenue. This led to the switch to dual-license AGPL in 2008 and now closed-source Stardog...
> Quality and reliability weren't controlled for in USSR.

That's a very strong statement. Could you elaborate on that a bit more please?
This is a hobby interest of mine but switching alarm systems off to do a quick
bit of work has caused at least three radiological accidents in irradiation
facilities in Nesvizh, Belarus, in Soreq, Israel and in San Salvador, El
Salvador. You can find the details in IAEA reports:

The one in Nesvizh:

https://www.iaea.org/publications/4712/the-radiological-acci...

The one in San Salvador:

https://www.iaea.org/publications/3718/the-radiological-acci...

The one in Soreq:

https://www.iaea.org/publications/3798/the-radiological-acci...

In each case the facility operator entered the irradiation chamber after
switching off safety mechanisms (such as alarms or mechanisms placing the
radiation source in a safe position, inside a pit) in order to unblock the
conveyor system from packages that had become lodged in the mechanism. These
facilities usually have a conveyor system that takes packages of products like
food or medicine around a radiocative source to be sterilised. The packages seem
to have a tendency to get stuck in the conveyor mechanism's parts often at which
point proper procedure is to power everything down before someone can enter the
facility to service the mechanism. Obviously that causes severe delays to
production and obviously people simply override this procedure, that is in place
to protect them. They go into the facility, they find the source in an active
position and become irradiated.

My favourite of the bunch above is the one in Nesvizh, where the irradiation
facility was built like a miniature maze from D&D, lacking only the guardian
minotaurs with double axes (or Ogres, I guess). The radiation chamber was an
actual maze, like a square spiral of concrete. The way to the source at the
center of the maze was littered with pressure sensors that triggered alarms and
there was even a moving hatch at the entrance that exposed a pit too deep and
long to jump over. IAEA's investigation never found out how the operator managed
to cross the pit, navigate the maze and get to the center of the chamber without
triggering any alarms that would have normally stored the source to its safe
position inside a dry pit, but he sure did it, then realised suddendly that the
source was in the active position and ran back out. He died later of radiation
poisoning before having the chance to tell anyone how he managed the feat.
Partner choice and choice whether to have children are other critical considerations in cost control.
Sure, I am mostly saying that depending on their situation they might not be able to afford to make the right call that will serve their mental health. I feel the crowd in HN is very privileged and regularly are lacking this perspective so I feel the need to point it out.

Thank you for the kind words. I am severely burned out indeed and always fatigued but at least I went to the doctors and have a few examinations due. It's a start.
It's not "infantilizing," it's linguistic mutation, and it's what languages do [0], for all manner of reasons. Text lacks intonation, plain text even more so, and internet dialect tends to evolve ways to add emphasis. In this case "pupper" is inflected to suggest endearment.

https://en.m.wikipedia.org/wiki/Grimm%27s_law
> What would i do in Maven?

Typically customization of maven goals is done via profiles. You can modify the configuration of the plugins depending on which profile is active. Though I'm obviously not sure if it will solve your problem without knowing exact details.
Because one tried and the ecosystems is such a mess that there's no real logical place to start.

If you are tainted by old knowledge, then there are things that you wouldn't even imagine is required. Why to I need NPM? JQuery and Prototype didn't need a package manager. You have a ton of tools, different tools for different frameworks even.

The more I look into modern JavaScript the more confused I get.
This page [1] suggests that "non-material damages (for example distress)" are sufficient to "claim compensation from the website [...] as they have breached the data protection law by not providing adequate security".

I've gotten spam calls since the breach, sometimes in the middle of the night while trying to sleep. That's distress.

[1] https://ec.europa.eu/info/law/law-topic/data-protection/refo...
I get this error on console (Firefox 83):

Uncaught TypeError: Error resolving module specifier “skruv/html.js”. Relative module specifiers must start with “./”, “../” or “/”. index.js:3:64
What I object to is we skipped straight from exploitation to paternalism. Freedom was never an option on offer.
For what it's worth, I recently went and traded in a pile of old Macs because I was travelling with a newer Macbook Pro (16" with M1 Pro) and needed to be able to effectively replace not only my first early M1 laptop, but also the iMac Pro I'd got as a flagship machine before the M1s came out.

Between those and an intel Mac Mini and an older iMac, I got over $3000 in trade-in value. Made me feel quite foolish for not having tried that before. The oldest iMac still got me a couple hundred bucks, as would your seven year old MacBook Pro most likely. A two year old high-specced computer?

I get that the list price for any of these is still way higher than putting together a PC from parts… but again, I belatedly traded a bunch of stuff in, and got more than $3000 in gift card value from Apple doing it. That makes 'rebuying a macbook pro every two years' a whole other state of affairs. I'm kicking myself for not having tried that earlier: I'm sure I left over $1000 on the table simply by letting recent computers sit around unused rather than immediately trading them in for Apple credit.
No, it's because they are worse than what Apple is shipping.
What do you enjoy about racket?

I used it for a semester in college, and it was next to unbearable. I can appreciate it as a fun little functional programming gimmick, but nothing more than that.
Anything preventing author or anyone else from putting in Github?
I'm not sure it matters if the allergy is life threatening or not. Again, you can't question the validity or scope of someone's disability under the ADA.

You need to read the rules more carefully: they mean Uber, in as much as it is in control of the rideshare service, can't deny people on that basis. The individual drivers can and their employer must accommodate them under the ADA.

If the drivers aren't employees and are self employed then as they are a business of less than 15 employees they can refuse anyone they want for any reason.
This post doesn't seem to be made in good faith.

> Is your mind open to accepting masks weren't that effective slowing covid-19?

There is a wealth of evidence[0] [1] [2] to confirm that masks are effective at reducing the spread of covid. Ignoring evidence does not mean you have an open mind. I would even argue it means the latter.

[0] https://www.pnas.org/content/118/4/e2014564118#sec-22

[1] https://www.cdc.gov/coronavirus/2019-ncov/science/science-br...

[2] https://health.clevelandclinic.org/new-study-highlights-new-...