jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
I think it's an open question. After this treatment, the patient's red blood cells will be producing a new protein that they have never produced before. This protein only differs from the previous one by one amino acid, so the question becomes how sensitive the immune system is to such a change. Given that the immune system has some difficulty recognizing cancer cells with multiple protein-coding mutations in them, I think it's likely that a single amino acid change will fly under the radar and not require any immune suppression, at least for the vast majority of recipients of this treatment.
Will you buy my coins back at a fair price?

What value do you provide? at least when I buy vbucks from Epic I know I'm getting fortnite skins with it.

Why should we run a node free of charge when you extract all the profits of our efforts?

When I see statements like "there's no economic incentive."

I read "I want all the profits, and screw everyone else".

If you genuinely wanted a decentralized network, then you would provide fair compensation for the added value the node provides against attacks on the network.
Look at these directions for using Popcorn Time with a Roku:

https://rokuguru.com/popcorn-time-on-roku/#/?playlistId=0&vi...

Compare it to the onboarding process for Netflix or Disney+ on Roku. I know, that for the median Hacker News user, this rises to the level of "nuisance," not a serious impediment. The median Hacker News user is not a very good model for the median consumer.
Unlike other similar (and often suspicious) websites:

- you do not enter your phone number (or email). You just search yourself (or your close ones) by name, the same way you would Google or Facebook yourself or your friends.

- even if that shouldn't be the only trust signal, we (the folks at NextDNS) work around security and privacy every day for the benefits of the users. And while we are still a startup, we are used by many, including experts in the security industry.
Regardless of whether it's social media or not, HN is a huge digital waste of time. Try to think of more than 10 posts that really improved your life over the years. Now realize that you probably look at more than 50 HN posts a day. I would spend much less time on HN, but it's an addiction, like most things digital.
I must agree with the parent commenter: HN is social media.

Oh, maybe it's not exactly like facebook or Twitter, but it ticks so many other boxes.

I could list many, and argue about them (arguing: another staple of social media), but the most important to me is that HN is effectively a procrastination tool, and it's associated with that mental "fix" of instant gratification.

It's different from facebook in that HN is more heavily moderated and more focused, but other than that, it triggers the same kind of (bad) habits, at least in my case.
Does anyone know why this is implemented?

As a...
– registered user
I want to...
– check the ‘remember me’ checkbox
So that...
– I am merely placated by the placebo effect
>Also feels like people adopt tools and cobble shit together from google/SO, what happened to RTFM.

Sometimes it's easier to google because TFM is written by people who are intricately familiar with the tool and forget what it's like to be unfamiliar with it.

Look at git for example; the docs are atrocious. Here's the first line under DESCRIPTION for "man git-push":

>Updates remote refs using local refs, while sending objects necessary to complete the given refs.

Not a single bit of explanation as to what the fuck a "ref" is, much less the difference between remote and local refs. If you didn't have someone to explain it to you, this man page would be 100% useless.
If you're curious about classical Iranian music, I highly recommend looking up Kayhon Kalhor. He is an extremely talented Kurdish musician (mainly playing the kamancheh, which is a sort of proto-violin) who often collaborates with Yo-Yo Ma. I particularly like Ascending Bird, in collaboration with the Brooklyn Rider. His duet performance of Morghe Sahar with Yo-Yo Ma is amazing too.

Hayedeh, Mohammad Shajarian and, more recently, his son Homayoun Shajarian are also amazing singers. Chera Rafti is very popular introduction to Homayoun.
Please don't do the language flamewar thing here.

We detached this subthread from https://news.ycombinator.com/item?id=10871532 and marked it off-topic.
As a casual reader of the NSA/GCHQ/Snowden threads on HM I have mentally check-marked nearly every comment of yours within this thread as a different form of documented tactic of subversion used by forum plants.

You sling personal insults, you point out trivial errors and falsehoods in statements by others which have nothing to do with the given point, you attempt to diminish reputations, and whatever other tactics available at the particular avenue in order to derail the original point/argument, while pushing pro US government talking points and stereotypical 'save-the-children' rhetoric.

I don't know who you are, but I have recently begun ignoring your posts, attempting to derive wisdom only from the replies directed towards your usually greyed/dead comments, but I hope that people who read my reply to you will take the chance to read your past comments and attempt to pick up on any potential biases before considering your opinion on things.

And even if I am completely wrong about your stake in this game, the hostility that you inject into these discussions is uncalled for, and adds nothing but scorn and hurt feelings, quelling the debate and discussion of the topics at hand; what I believe is your very objective.
And let you use them in the immediate window. No more hacks to figure out what element of a list/array is blowing up your code!
You're not convinced that it's bad for the government to deliberately overpay for projects in order to funnel money into the pockets of its political donors?
Brainfuck is faster than C. You should use it for all new code where performance is critical.
> watching paid professionals playing sports via a long chain of technological and market devices.

Again you bring technology into it, when spectator sports have existed long before the first Colosseum.

> Pornography is easily among the worst offenders.

How? Why?
I don't know what the parent means however isn't it true that some cities in the US stopped prosecuting some crimes deemed "petty" such as theft, "hard drugs" dealing, …

Which would make crime statistics lower than they really are.
It's from 2017, but this is still relevant: https://www.londonreconnections.com/2017/understanding-uber-...
That is basically just a snarky way of restating the premise of the monopoly on violence[0].

And we do want to be like that, in theory, because violence cannot be avoided entirely in human interactions, and because violence as a regulated market is more humane than violence as a free market, and because that violence in the former case is mostly abstracted into the bureaucracy. For many people in a modern society the closest they'll ever come to seeing the "violence inherent to the system" is maybe a speeding ticket or misdemeanor jail time.

[0]https://en.wikipedia.org/wiki/Monopoly_on_violence
By the time it is implemented things have already gone horribly wrong.
What is 'the rest of the world' supposed to do? It's not like they don't have access to internet or condoms (even free), not in 2019. It's a (collective) choice.
See [1]. It's about Niger (same largest ethnic group - Hausa[2]), which is also experiencing a population explosion, but the principle appears to be the same:

>“I just pray to God to bless those three babies I have,” she says. The local health centre in her village of Darey Maliki offered her free contraception, which they get partly from the NGO Pathfinder, but Hamani declined. “Maybe [my in-laws] would tell my husband to marry another woman to have more babies,” she says. “If they want me to have another pregnancy, I can do it just for them to feel happy.”

Perhaps that culture changes in the future generations, but for now Subsaharan Africa is on track for 2B+ in 2050, and nothing short of starvation or violence can change that.

[1] https://www.theguardian.com/global-development-professionals...

[2] https://en.wikipedia.org/wiki/Hausa_people
Some very serious work was put in writing this book. I admit I never fully read it from beginning to end, but from the parts I did read I think it is very well written.

My general advice for beginners who want to get into reverse engineering is to read less books, and try to actually reverse engineer small and self contained programs. Reverse engineering has been my job for many years now, but it still very difficult for me to consume a long text talking about a reverse engineering project without touching the code on my own.

If you are interested in a hands-on experience, I recently made a self learning kit for learning reverse engineering for beginners. It is called ReversingHero. (https://www.reversinghero.com). It is one binary file made of 15 levels of increasing difficulty, teaching reverse engineering. It works in Linux environment, on the x64 series, and can also be completed using WSL (Windows subsystem for linux).

ReversingHero also contains an accompanying (paid) video solutions. The video solutions contain 12+ hours of step by step solutions to all the levels.
Outside government and government contractors, being a part of a cost center is not the path to a happy life.
I see. Yeah SZ definitely a more vibrant city. But am stuck in GZ for a while. It's alright. Will figure out something. I'm connecting with people in the contemporary art scene here. They are pretty nice.
The same one I mentioned before: getting other people to use it benefits them, as other people will help maintain it because they also have a stakehold in its success. It's a huge project to maintain.
A bit cheaper off DX:
http://www.dx.com/p/meegopad-t01-quad-core-android-4-4-windo...
No it isn't, at least not when the article was written, and I can't see why that would have changed in the past 30 years. The article discusses how it's basically impossible to sell a diamond for anything near "market value" (as far as that term makes sense in the context of a global near-monopoly) and how a lot of places won't pay cash for diamonds at all.
I'm pretty certain that it's been included, in pretty much the same form, since 10.0.
I respect the chops of those creating these things but I just don't feel like I'd want to use them daily. Perhaps I'm already locked in to a legacy mindset by my mid 20s!
I think you mean disingenuous.
Their incentive is to make it look cool, wow an audience, and bring more grant money to the MIT Media Lab. Contrast this with a company that puts the pieces together and ships a useful product - like the iPad UI...

I always thought crazy concept cars were a waste of time and resources for car companies. If they instead focused on massive in-house iteration (like Apple's 10-3-1 prototyping process), better cars would be brought to market.
If you are a business, you have an accountant. If you have an accountant, use a tool that the accountant can handle. They all know Quickbooks. Use the PC version or the Online version. The Mac version is shit and my business is all-Mac so I would use it if I could. You will have payroll. QB Payroll is painless and relatively cheap. I'm a tax lawyer and I won't touch doing payroll tax stuff. Too nitpicky.

Kashflow in the UK is good. Xero is another to look at. But only if your accountant is using them.

Do. Not. Be. Your. Own. Accountant.

Also, if you have any outside Investors they will want clean financials. QB operated by an acccountant. If you hope to bring in Investors later and you have shit financial records -- or just amateur hour financial records -- the natural thought in Mr. Wallet's brain is "They can't handle their own money, why should I give them mine?"

All comments above learned the hard way, via pain. :-)

I have no particular love for Intuit. QB is the Windows of small accounting systems. The Mac version is the despised bastard offspring despised and ignored by it's mother. But until you're bigger or until a plausible alternative arrives, use it.

I think the break-point will be at a couple of million of revenue. Above that and growing? Migrate to an industrial-strength package with dedicates bookkeeping people in house.
I know the screenshots in the store are lopsided, and yes we have an Android app already (http://linkup.com/android). We're working on a HTML5-enhanced version for the site, but until then I hope people find this useful.

There are 2 other iPad-exclusive job apps, and I'm hoping ours is the best - but figured that there is no community more brutally honest than my fellow HNers:)

(Also, if you don't have iTunes installed, you can view it at http://linkup.com/ipad or at http://itunes.apple.com/us/app/job-search-xl/id372602126?mt=...)
There are tons of tech companies that are north of that Redwood Shores complex, virtually all the programmers I know work north of there actually.
I think the mocking is not the mundane and boring source, rather the logic of "I drive fast, and I have a cat so it must be toxo."

That's unsound logic, no matter how mundane or extraordinary the housecat is, because habitual fast driving happens for any number of reasons of which toxoplasma gondii is possibly one.
Strange, pressing the 'Escape'-key on that webpage sends me to https://timothy-stack.squarespace.com/config
Good points @chrisa. I hope you keep inspiring other devs, friend
A program is easier to use. You do not need to link to it, just run it! Do you have trouble running programs?
So in Ireland we have a split system. The public system, it's not an issue; the state pays. If you have private health insurance and go to a private hospital, they'll... check with your insurance that it's covered beforehand. Which just seems like common sense, really; do they not do that in the US?

I suppose emergency medicine is done in US private hospitals, which to a large extent doesn't happen here; private hospitals would typically do elective stuff. But presumably that doesn't apply in the case in the article, so why on earth wasn't the hospital required to check first?
One of the voice actors is John de Lancie!

https://soundcloud.com/user-860705643/q-pandemic-rant-no-mus...
Same in the Netherlands, School WA group, Class WA group (for both children), Sport WA groups (for both children), Children's birthdays WA groups, Family WA groups, Neighborhood WA groups (oh yes, we see this in many streets: [0])

[0]: https://duckduckgo.com/?q=whatsapp+buurtpreventie&t=ffsb&iax...
> But the fact that it only costs 9 cents a GB is amazing.

9cents in India would be equivalent to 1.91 USD after taking into account Purchasing Power Parity (OECD 2019). Therefore, you are in effect saying 1.91 USD per GB is amazing. You can not compare values without including purchasing power disparities.
I didn't feel like writing 99.9999% chance at the time, so I rounded up to 100%.

It's not insurable in the sense that at some point, the losses are so large and so frequent, that the insurer needs to collect premiums from almost everyone in order to cover the costs. At that point, the premiums start to resemble a tax. I actually do consider the premiums a tax for the following reasons:

1) there is a mandate to purchase health insurance (although now neutered in most states due to removal of federal tax penalty)

2) the maximum premium is set to 3x the lowest premium (means young people subsidize old people)

3) premiums can only vary based on age and tobacco use

4) there is an annual in network out of pocket maximum

Another example of an uninsurable risk is insuring homes on the Florida and other Gulf states coastline for flooding. No private insurer would touch this market since the losses are so high, so the government created the National Flood Insurance Program, which is the federal taxpayers taking on the liability for flood damage for those homes.
The creation/redemption process is intended for market makers known as Authorized Participants (APs) to arbitrage differences in the ETF price and the underlying price. While, yes, you can sell bitcoins to the trust in exchange for shares of the ETF, you would then need to sell those ETF shares in the market. So in other words, you would only have liquidity if there were demand for the ETF. It's possible that there will be more demand for the ETF than for bitcoins simply because ETFs are more accessible.
I think there's definitely a trend in institutions to integrating these fields. Princeton has an Integrated Science program [1] which includes highly quantitative study of biology.

And genomics in general has forced the combination of biology, stats, and math. Classical genetics and evolution departments are often seeded with lots of appreciation for mathematics, as well.

However, pure molecular biology doesn't often have that much to say to non-applied math, and vice versa.

http://www.princeton.edu/integratedscience/
1. Join the challenge
2. Get any module assigned
3. Check the gaps in it's test coverage using https://metacpan.org/pod/Devel::Cover
4. MOAR TESTS
5. Profit!
Black Mirror is brilliant! I can also recommend Utopia.
If the SEC approves it, this would be great news for bitcoin.
Assuming the ETF is sufficiently liquid, it would allow:

- easy shorting of bitcoins which facilitate price discovery

- lower transaction costs. The cheapest and most liquid exchanges still charge .2% per transaction + spread. Most (all?) of them charge you for getting cash in our out of their platform. Buying shares of an ETF would cost just spread + transaction cost charged by your broker which should be much lower (.0035 per share on Interactive Brokers for example)

- easy hedging of a real bitcoin position. Let's say you hold a large fluctuating position in bitcoin that would like to hedge in USD. You could continuously convert all your BTC to USD or go long/short the ETF which is much cheaper.
Not all basketball talents play at the NBA. And there are musicians after Mozart and the Beatles. Look at people you can admire, and make even tiny steps by their standards. You can be 10% Bill Gates (example, pick your own), or 1%, or 0.01% or 0.0001%. But you are both on the same track. The important thing is to push your limits to something you believe is worthy and that you can give a unique contribution that pushes that something an inch forward. Good luck.
Side rant: Github devs, if you're listening, please give us REST API. Not everyone knows GraphQL or has the motivation to do so. The industry standard is REST for public facing APIs, including companies such as Stripe (widely considered to be the gold standard for public API design and documentation). You can use GraphQL internally.
Mars is very cold, things like the battery can't handle these temperatures. It's been thoroughly analysed, here is a quote from the white paper [0]:

"""H. Thermal System

The helicopter must survive the cold of the night on Mars where temperatures can drop to -100 C or lower. The most critical component is the battery which is kept above -15 C through the night as it powers Kapton film heaters attached to the battery cells. The avionics boards in the ECM surround the battery and are also kept at an elevated temperature by virtue of their proximity to the warm battery assembly. Insulation around the avionics boards is provided by a carbon-dioxide gap of 3 cm width. Additional insulation can be provided by replacing the carbon-dioxide gas with an Aerogel formulation. The outermost fuselage thermal coating is from Sheldahl with Solar absorptivity α = 0.8 and infra-red (IR) emissivity = 0.1.

In addition to thermal losses through the gas gap (or aerogel), additional losses occur due to conduction in the mast as well as through the copper wiring that penetrate the ECM from the mast. To minimize the latter, the wire gauges are selected to be of the thinnest gauges that can still support the current draw during operations without overheating. Prior to flight, under the control of the FPGA, the thermal system powers on heaters in the motor control boards that have been exposed to the ambient temperatures. The internal battery temperature is brought up to 5 C to allow hi-power energy extraction from the cells. During operation the ECM and battery warm up as a result of avionics operations and battery self-heating. However, the thermal inertia of the elements is such that for the short flights of the helicopter, there is no overheating."""

[0] "Mars Helicopter Technology Demonstrator" https://rotorcraft.arc.nasa.gov/Publications/files/Balaram_A...

EDIT: some detail on the battery capacity from section G:

"A de-rated end-of-life battery capacity of 35.75 Wh is available for use. Of this capacity, 10.73 Wh (30%) is kept as reserve, night-time survival energy usage is estimated at 21 Wh for typical operation in the northern latitudes in the spring season, and approximately 10 Wh is available for flight. Assuming that 20% of the power is at the peak load of 510 W and 80% is at a continuous load of 360 W, approximately 90 sec of flight is possible. These energy projections represent conservative worst-case end-of-mission battery performance at 0 C initial temperature. More moderate power loads will extend the flight time."
I genuinely do not understand how deflation could ever be a concern in the US when the fed can always fire up the printing machines.
I haven't used it myself, but based on their blog, Dolt looks like a nicer way to share tables of data in a git-like way, since you get both branches and merges and SQL support.

https://www.dolthub.com/
I just started using git annex, which is an extension for large files.

https://git-annex.branchable.com/

I like it a lot so far, and I think it could be used for "cloud" stuff, not just backups.

I'd like to see Debian/Docker/PyPI/npm repositories in git annex, etc.

It has lazy checkouts which fits that use case. By default you just sync the metadata with 'git annex sync', and then you can get content with 'git annex get FILE', or git annex sync --content.

Can anyone see a reason why not? Those kinds of repositories all seem to have weird custom protocols. I'd rather just sync the metadata and do the query/package resolution locally. It might be a bigger that way, but you only have fully sync it once, and the rest are incremental.
Isn't taking levothyroxine without doctor prescription dangerous ? I mean this is a drug, not a Vitamin tablet.
Very cool. I looked into this myself a couple years ago and the fact that the transaction data was in PDFs and that across years and representatives the format of the PDFs was all over the place, I gave up. Great to see someone else took it more seriously than I did and put the work in
This is the model we use with self hosted Domestica (https://about.domestica.app). You own the premium version, indefinitely, up to the version your subscription expires on.
Well if you frat boys will stop calling black people n*ggers, then we'll stop calling you frat boys.
I've had troubles with the web interface and with pushing/pulling on and off since Friday
Following your point of view, code-academy's approach is equally shitty. The airbnb "website" is not just a front-end with some HTMl/CSS and 4 png images that you've put together and will give you an airbnb clone.

There's a heavy backend, multiple servers to setup, manage and monitor. Then there are databases, SSLs configurations, privacy concerns, http requests that need to be routed, emails that need quick replies, fault-tolerance strategies, CDNs, authentication schemes, payment gateways, rating systems, backup schemes...

Did Code Academy teach how to handle all of the above or are you referring to a front page that I could fetch and regenerate in 20 seconds using curl?
I bet if you limited the range to households with college-age children, the median would be much higher. Those are peak earnings years for most people.
If this is China doing this, it makes me so upset the US has spent years and billions of dollars building up their economy instead of countries like Mexico.

Our relationship with them is almost as bad as our middle-eastern oil addiction.