jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
Neoplastic TKs are not on/off switches; they are always on. Once you inhibit effectively, they are always off, like you said. But you still have a copy of the normal TK, so most likely things could be perfectly normal if you identified a highly specific TK inhibitor. The current -inibs just aren't specific enough yet, so they have serious side effects.

I argue that antibiotics get to the heart of an infection, not that they only kill the bacteria you want to kill. Is it possible to create a drug or engineer a phage to do wo? Yes, sure. But the cost tradeoff is not worth it, on balance. Very few people develop any side effects from most antibiotic treatment, much less weeks of GI discomfort. It definitely happens, but you outlined the treatment for it -and eating yogurt is much cheaper than paying for a theoretical, patented, new superantibiotic that causes mo GI problems.
If there is any advice to live by as a parent, it is that 90 per cent of being a parent is showing up.

At that point, you've probably overcome the biggest hurdle.

Take it from someone whose parents didn't.
Not to state that the exception proves the rule, but my company actually makes use of two racks of IVR servers on a daily basis and we love them. Speeds up the inbound call process ten fold from 2009.
What I find irritating is that a neuroscientist would be so easily drawn into mysterious, magical thinking about what was going on in her head.

Of course, I suppose I might see things differently if a blood clot turned half of my brain off for a while.
"k" and "bucks" are rarely used together, so I think kiba means dollars. While the amounts might be small to you, be careful of putting it down - everyone has to start somewhere, and better to be excited to be making anything at all than depressed that it's not much.
Chrome and Safari have a REPL console - you can type JavaScript and get immediate feedback.

Great idea for a library that builds on what modern browsers can do to provide an environment that is similar to the old micros (I started programming on a Apple II).
It has happened in Wuhan. Mortality was 0.7% outside the quarantine zone and 5.8% inside.
just "torn" not "torn apart" -- which is quite a violent thing!

"torn" in this context means to be not decided between a couple of opinions or decisions.
Also, out of the movies/games you particularly enjoy, softly ‘leaning’ into the parts that you find easy to indulge in (I do this in the form of repeating a certain creative/qualia segment of the media in a loop and letting it continuously ‘affect’ me) can be an interesting psychological exercise.
What is the false positive rates of this, if 10k people are tested everyday, can we expect 100 false positive everyday?
Yeah referencing/re-enacting movies is such a great way to transfer implicit knowledge
If only Apple ported HyperKit over and let us run a fully sandboxed, virtualized ARM userland... iSH is great, but not enough.
"Immortality within our grasp"?

The world is fundamentally evil. 160 million dead via war in the 20th century alone.

Optimism in this matter is incredibly naive.
GitHub has a similar "living" style guide that is open source: http://primercss.io/
I do not see the value of local social.

An island somewhere has re-affirmed my beliefs not shattered them.

9gag and reddit and etc I think have anonymous posting covered pretty okay without introducing a new "login" concept.
The page looks beautiful, but the animation is janky on my FF36
NLU. It relates to extracting intelligence from human language. Most of which comes in the form of text.
Something that doesn't get said enough is that Google had a habit at the time of buying RAM chips that had failed manufacturer QA, stuck them on DIMMs themselves, and revalidated those DIMMs. They were really leaning into the whole "embrace failures if they're going to happen anyway and you can get cheaper servers out of it". So those numbers need to be taken with a grain of salt.
What limits did Trump admin put on them? They bullied them into up weighting Conservative content and down weighting Liberal content but I doubt that changes.

https://www.motherjones.com/media/2020/10/facebook-mother-jo...
So you understand every state uses similar dirty tools of power. Where do you start changing that? There is no upside for any big state to unilaterally respect and build international law / UN while others take advantage. It is a mere toothless idea now, these states don't have much incentive to follow it.
It’s an interesting theory; on the other hand people domesticated birds of prey to assist with hunting as well (falconry).
I miss hangouts SMS integration. It was super easy toggle SMS/Hangouts as the method of sending and clearly displayed grey if it was going to be SMS.
We made this Google Sheets plugin to calculate your basic SaaS metrics: New MRR, Expansion, Contraction, Churn, MRR, LTV, ARPU.

Maybe it will be useful to someone who uses Sheets to track their company financials but still would like to calculate the metrics.

Disclaimer: it does send data to our API (we don't store it but still...)
https://www.youtube.com/watch?v=G8lblosRKsQ ;)
How do Twitter know the difference between a russian that doesn't like NATO and a state founded undercover PR consultant? Banning accounts on the combo of nationality and polical beliefs is shady.
When I read about the experiences of nurses I am reminded how easy my tech job is in comparison. Yet I get more pay, more respect, more flexibility, and less stress.

For the attention to detail required by oncology nurses. I bet they would make excellent programers and make a lot more money. If I ever end up in their care, I hope I remember to be filled with enormous gratitude that they could have chosen an easier path, yet instead chose to care for me: a stranger.
Служу Советскому Союзу
The best part is transactional ddl statements. You can do your database migration in a transaction, if something fails the transaction is rolled back compared to an invalid state with mysql.
Because fuck ethics, right?
I always find these kinds of thought processes interesting "day trading always leads to losses". As with poker, anything which is predictable can lead to meta strategy which can be gamed: this is why GTO players can be outplayed by player-focused players, at least on occasion.

But occasion matters! Life isn't a nice continuous stream, it's lumpy. Circumstantial performance makes a difference - and that's why Greece could win the Euros despite probably not being a good football team.

Day trading is probably quite a hard discipline to follow, but that doesn't mean that everyone who does it is destined to fail.

Anecdotally 50% of marriages end in divorce but that apparently doesn't stop most people getting married...
My two college-age siblings plus both parents are all on a Verizon "family" plan with something like 1000 minutes. It's absurdly stress-inducing, with fights and fingers pointed etc if the minutes start to run out.
11 minute abs.
I couldn't find that line in the article?
Connect is a misguided effort IMHO, but as the creator of JSGI/Jack (http://jackjs.org/) I'm of course biased.

JSGI is a lot more elegant. It's more of a functional style (apps are just functions, middleware are functions that return another app, a function), asynchronous support is handled via promises. Connect is very much tied to the Node stream APIs, and ends up being more convoluted and difficult to understand, IMO.

Here's an analysis of Connect vs. JSGI by Kris Zyp: http://www.sitepen.com/blog/2010/06/11/jsgi-vs-connect-for-n...
Yes, as I was designing this, I thought, okay, 300 updates becomes ~100, fine. But what happens when I'm on even on more networks, and ~1,000 updates becomes ~300? Would then I need another layer on top of that to further reduce the deluge?

Maybe a "pin" and "unpin" feature that would pin these people to the top could work.
"For example, I like the concept of ranking a page higher based on how other sites link to it (ie Google's Pagerank), and would enjoy conceptualizing further improvements, but I would find it extremely boring to translate that solution into code."

As far as I've gathered, there are two steps to learning a foreign language. One step is when you think in your own language and translate everything over. The next step is when you think in the language. Enjoyable coding comes only when you think in terms of the programming language. But that only happens once you run into problem domains where you have substantial thoughts, and once you use languages that allow for those kinds of thoughts. Or, once you're used to one type of language and one way of thinking about things, learning to speak another is enjoyable as well. (Imperative vs. functional programming, etc.)
Well, it might be confusing, yes, but the Flock browser might not be happy about you using the name (especially considering the similarity between the browser and your project).
> It's hard for me to imagine anyone getting harassed over this
You seem to have some bugs with the copying of champions and/or the identical reproduction of walks at the very short simulation length. Without having adjusted simulation parameters I no longer have my highest scoring walker saved as a champion.
I've spoken to a few professional arrangers, and I always ask "How many times did you have to listen to that to write it down?"

"Just once."

Genius indeed. Or 10,00 hours. Or both.
Perhaps the frequency caps could be expressed in ads per batch and ads per time unit.
Implemented via several dozen geographically distributed 1U servers with 10 or 100GbE network interfaces, and anycast DNS. You could do it pretty much the same as anycast DNS recursive resolvers, but all sharing the same hostname, IP and TLS keys.
“The document mentions sworn statements regarding mail-in ballots and actions that could lead to election fraud, and that the case asks to be investigated.”

Investigation is not a remedy given by courts.

Investigation is what litigants do to develop facts to bring to court.
Is there any published technical evidence to look at which actually implicates JetBrains? CVE or a POC? Publication of the poisoned build of the CI software? Indicators of compromise?
Many of the US's problems have been subdivided along political lines such that no solution can be brought forward as both sides benefit from the lack of a solution.

3-4 decades of utter gridlock has left the country with both a power vacuum and many aggrieved parties looking for a break from the status quo.
"This summer, shortly after scores of camo-wearing, heavily armed federal agents descended on Portland, Ore., to attack protesters, Charles Fried, Ronald Reagan’s solicitor general, pondered the implications of what he was seeing on the streets. What he saw scared him; he remembered the use of paramilitaries by fascist leaders in 1930s Europe, where he was born, and he feared he was now witnessing a slide into paramilitarism in the United States. (His family fled the Nazi occupation of Czechoslovakia.)"
You're potentially risking your life but certainly trading your reputation and taking on stress for not a particularly worthy amount of money.

Plus then you're on the government's radar and they think you're money-motivated, not patriotism-motivated. Everyone involved in any cases brought with your help will think poorly of you. This might turn into cases brought against you. You will never get a government job. Your identity will probably be exposed as an informant at some point -- usually through public court records.

If you actually are patriotism-motivated, go join the agency. There is no upside to informing on people.
There's artistry in mechanical engineering, electronics, etc., too.

Take a close look at various bridge designs, and you'll see the artistry.
What are you counting as 1.x, Pre-Constitution?
There’s a Singularity driver for Nomad

https://www.nomadproject.io/docs/drivers/external/singularit...

Nomad is pretty darn easy to run and scales far. I help run about 20 clusters in day job from 100 to 1800 nodes, we’re going to push one of them to over 8500 nodes here soon too.

We don’t use the Singularity driver but we wrote two of our own and they work well and are easy to maintain.
There are two parties in every gambling transaction.

What about the responsibility of the house to detect ordinary people gambling way over their means?
Thank you Gawker for bringing password security issue back into limelight.
My caffeine intake is basically nil, but I still often feel drowsy when I wake up, especially from an alarm. It's usually when I haven't sleept enough, but sometimes if I've been sleeping roughly enough, waking up from my alarm leaves me very drowsy.

Sleep is very complicated. Just because dumping caffeine fixed your drowsiness doesn't mean it'll fix everyone's.
I'm in the same boat, mate. I'm a Junior majoring in Computer Science and Engineering. Lately, I've been getting more and more frustrated at my complete lack of time that I can devote to doing what I actually care about: starting up TextMate and programming.

I've thought about a few options and to be honest, I still don't know what I plan on doing. But it's cathartic for me to think like this.

The way I see it I have a few options. Note that all require some sort of sacrifice:

1. School requires a lot of time because that's the time that's required to achieve high grades. It's not easy to get an A in a course and that often comes with doing a lot of work and assignments. Yet, it's still possible for you to learn what you actually needed to learn from the course while not doing every little tedious exercise. That frees up time.

Example: Last quarter, I had this really awful EE class. I understood the basics of the course, as evidenced by my midterm/final grades (both were 91%, some 20% above class average), yet I didn't bother to do most of the homework. That was 20% of my grade and I got a C+ rather than an A because of it. That's the sacrifice...but on the flip-side, I got a solid headstart on a personal project that I'm really excited to work on.

Second example: There's a little story out there about Zuckerburg when he was creating Facebook. He allegedly had stopped going to class or focusing on his school-work when Facebook started taking off.

2. Consider doing a major besides EE/CS if you already know how to program. That frees up your time and you could easily get work done on your startup on the side with an English or Economics degree.

3. Admit that you can't focus on a startup and get great grades at the same time. Tough-it-out for a few years and start thinking about startups once you graduate. Do things like have a life and having fun now.

4. Consider starting something with a few co-founders to alleviate some of the required invested time.

5. Think small. Don't think of a huge time-consuming idea. You don't have time for that AND getting good grades.

I'd love to talk more. Email's in my profile if you're interested.
I'm wondering the same thing. I have a dual major (Computer Science and Chemistry) and save the holidays I don't have any time to give a startup. :( I have way too many ideas that I want to eventually implement though, all saved in Google Docs for later. :)
Go Java! I'm kind of shocked he uses Eclipse instead of IntelliJ though.
Thank you! This looks fantastic, and I am very glad you shared this.
It works with newer generation iPod Touches or iPad, so if you really wanted one, you could always buy one of these devices to use it with.
I started working for a start-up sophomore year as just a EE. I decided after doing so much hacking / coding that I would like a more rigorous CS training as well.
I love apache
Same, I did find a good collection of Hubble telescope pictures the other day and set them up as a screensaver though.
It's like use iron for any work just because it's most widely available element on the Earth.
I agree, imho there isn't any decalarative and powerful way to build UIs as AutoLayout.
> But they might want to optimize for "people in their league," especially if the fear of rejection is in them like the guy in OP.

I think folks should try not to worry about that too much: http://imgur.com/gallery/eo5oq
The issue is not the money - it's the ability to integrate.

M&A and cooltech is by far the easiest part. Making use of the tech, the talent, operational integration, re-writes vs. integration, product alignment, etc. it's very hard on every level.

What do you do with the VP of a 50 person company, now they are managers in a little team, the software might be discarded, or just a few ideas used from it etc. etc..
Music, movies, books, newspapers - I can get all of these painlessly on the iDevice without the Apple tax. The only lockin I have with the iphone/ipad, is iTunes. That's an aggravating piece of software, sure, but it doesn't really lock me into paying apple anything.

PS- When i say newspapers, I mean news delivered digitally. Not issues, so to speak.
I don't particularly care for the institution of marriage, although I will say that I think weddings are tons of fun, and the only issue I have with the decline in marriages is that I don't get to go to very many of them.
Yes, I will. I've been holding off until I got the type inference to be less hacky, but that's not really necessary for it to be useful.
This 10 000 hour rule (or let's see with this 1k h rule) is liberating: you do not have to be a genius to start. Again that does not mean you will be a genius but no genius got to be one without 10000 hours. Herbert Simon talked about the 10 years rule.
As an outsider looking in, meaning I don't drink caffeine, this guide seems like something only an addict would create.
It's the same for most cities and even towns, I'd imagine, eg. Sheffield (baffling one-way system to visitors), Birmingham (one way streets, central road by New Street actually leads to an underground car park if you're not a bus), Coventry (roads that go nowhere in the city centre, bus lanes that appear and then disappear after only a few hundred metres, cut across roundabouts etc). Try Redditch with its unnavigable ring road system - how do you actually get to the Vue cinema in the central shopping centre, even with a GPS???
Even towns with a grid layout (eg. Leamington) have no right or left turns across the grid so you have to follow a certain route around the town.

I think it's just symptomatic of hundreds of years of town growth.
I disable v6 on any linux install unless I specifically plan on using it. The fact that it can easily be accessible over lan and over the internet due to how good the auto addressing and link local addresses work is a concern.
This is precisely the way a market for lemons works. Scumbags like you thinking it's ok to prey on the less knowledgeable human beings we live with.
I know my v6 prefix by heart actually, but almost never get to use it.
What, like Sylvester Stallone? Why would he do such a thing?
I'd say that the underlying phenomenon is classic xenophobia. These are just specific cases of it, where the "foreign/different/alien" thing is someone's sexual or gender preference, or even opinion on the validity of those things. (EG it's possible for a homosexual to be anti-homosexuality: their tribal affiliation's homophobia is stronger than their personal sexual orientation. Then you get headlines about a "Wide Stance".)
I don't think there are an infinite number of positions. The Planck length [1] essentially defines the smallest unit of length. Similarly, Planck time [2] does the same for time.

[1] https://en.wikipedia.org/wiki/Planck_length

[2] https://en.wikipedia.org/wiki/Planck_time
We routinely make known scams illegal despite fact that the "fault" lies in the individual being scammed. Not saying Uber is a scam, but "victims should know better" isn't a valid defense of it.
True, but all we have left of this particular artist is the negatives; manipulating them is changing it from their art to the art of the person doing the manipulation.

Not a bad thing in and of itself, but it represents a loss, in my opinion.
This is a great comment - while many people are complaining about Apple adding too many features and introducing bugs, you are asking for more features.

This is exactly the dilemma Apple faces and is the reason that simplistic answers like 'stop releasing every year' are unhelpful.

The real interesting question is - is there a way for Apple to both maintain the pace of development and improve quality simultaneously.

That seems to be a challenge worthy of the most valuable company in the world.
Very cool, love the variety of demos. :)
GPU acceleration isn't going to be practical until >WebGL2, when we get access to compute shaders.

You can technically do compute now by expressing your data as textures and performing rendering passes over it, but trying to do anything non-trivial that way will quickly lead to madness.
Those cuts are typically referred to as "rebates", and yes, they're standard operating procedure.

There's an interesting history behind how this practice got started, that's a good lesson in how multi-party markets work. Back in the good old days, touring acts typically got a modest percentage of gross ticket sales for a given concert, leaving enough for the promoter and venue to cover costs and make a profit.

At some point (the 80s, maybe?), artist percentages started creeping up closer to 100% (in one ridiculous example, Jimmy Buffet got "105% of gross ticket receipts"), so venues and promoters had to make money on something other than tickets.

Since "ticketing fees" weren't calculated into the gross ticket receipts of which a percentage were due to the artist, they were a green field for exploitation and creative deal-making, like the "promoter rebates" referenced above.

In many cases (almost all venues above a certain size), venues sign exclusive ticketing company contracts that come with up-front bonuses or advances on fee rebates, which make ticketing companies kind of like cash machines (or payday loan vendors?) for venues.

The general public perception of "ticketmaster is evil" is, as with most things when you look beneath the surface, much more complicated than it appears.

Scalping itself is a related but different issue that ticketing companies and venues could certainly limit or end if they had the will, but the system works just fine for them, so there's really not much incentive to change.

[sources: various anecdotes from music industry veterans who will likely deny a lot of the above if pressed ;-]
Having worked as researcher/dev in both private office and open space setup, I am absolutely convinced that private offices are way more productive than open office setup for researchers and developers. Most, if not all, of my colleagues feel the same. In fact, I don't think I will ever accept an offer from a mature company (not startup) which houses its developers in open space.
Would you really want all the information the NSA collects to be shared freely between agencies?
1. Even Apple borrows money for buybacks rather than spending their giant cash hoard. The reason is taxes. Companies have a lot of cash generated overseas, and if they brought that cash back into the US in order to buy back stock, they would have to pay US corporate income tax on it, at a rate of something like 35%. From that perspective, a 2% fee to the bankers is a steal.

2. As far as I know, most corporate bonds don't have a floating interest rate, so those companies have the option of paying off the bonds at maturity and then just not borrowing more if interest rates have risen. They don't have to continue the buybacks under that scenario, because investors don't expect buybacks to be consistent from year to year -- another advantage over dividends.

3. Pouring money into R&D instead of returning money to shareholders only makes sense if the company can get a better rate of return than shareholders can get somewhere else. For a large, mature company that may well not be true. In that case, they should stick to what they do well, send the profits back to the shareholders, and let them invest it into some growing company which can make better use of the money.