jkeisling/hacker-news-corpus-2007-2022 huggingface dataset:
> I don't have the time to fully deconstruct this paper,

That's why you did not understand it.

> but after a skim I'm left with the question, "so how does
> a single protein achieve non-linear response?"

If you read the paper carefully (also the Supporting Information), you would see the origin of non-linearity. Transcription factors (TFs) bind to the operator and unbind from it. We make an assumption that this process of binding/unbinding is the fastest of all processes in the system. That is why we can describe it in a continuous way (so we do not consider TF single molecules, but their concentration, which is a continuous variable). Under such conditions, the transcription rate is a non-linear function of the the TF concentration. This is explained in the Supporting Information of the paper for the general case of n binding sites. Here I explain it in a more verbose way for the case of 2 binding sites: http://th.if.uj.edu.pl/~ochab/h.pdf

This non-linear function acts as a noise filter: If the TF concentrations across a cell population are not same, but given by a statistical distribution (one may call it "noise"), then the output distribution of transcription rates will be transformed in a counter-intuitive way. For example, a unimodal input distribution (of TFs) can be converted into a bimodal output distribution (of target proteins).

So far, no one have found an analytical method of prediction, when the output distribution of proteins in a typical open-loop gene regulatory system will be bimodal. Even in the case of cooperative TF binding. Moreover, no one expected that bimodality can be found also in the case of non-cooperative TF binding. Which is kind of surprising, because the idea itself is simple. We did this. What is especially nice in our work is that the conditions for bimodality can be found without complicated calculations, only using a simple geometric construction that involves quantities that can be experimentally measured.

> This paper seems to provide a mathematical model without
> giving a good explanation for how it would be achieved in
> nature.

This is certainly not true. Please see the references, especially Friedman et al. PRL, Cai et al. Nature, Nevozhay et al. PNAS, Dublanche et al. Mol Syst Biol, and Taniguchi et al. Science.

Best regards,
Anna Ochab-Marcinek
The rub is always: association with the group is association with the worst of that group.

Their worst right now is much worse than expected, I would be ashamed to be associated.
> Irrelevant

They allowed the group to build and grow then once they moved off they killed the sub?
Do you work for them? The way data brokers work, from what I understand, is that it's a 2 way agreement. You only get the data if you give data.
I think it's impossible to say. The fact that the capitol got stormed the same day as the democrats won control means it's impossible to disaggregate. It might be a cynical move by Facebook but is it also a cynical move by Betsy Devos? What difference did democrat control make to her?
>Musk’s whole empire would have been in jeopardy

He says this himself in the SolarCity lawsuit deposition, I believe.
Unclear to me why this type response is repeated twice here, I think the point was more the DOJ and FBI have been sitting on their hands while things escalate to this recent level
Quite literally? Biden had ~81mm votes, Trump had ~74mm votes - and the US has a population of ~330 million.

Edit to add: Downvoting facts?
> Goes to show that the notion of "nation" has fuzzy borders.

Or that these aren't nations but empires pretending to be nations.
> Please cite me tweets/descriptions of where he incited anything.

It's not gonna happen, because it didn't happen. I've asked everyone I know to cite the same thing, and no one has been able to. Of course, that won't stop the narrative, because truth has become irrelevant.

EDIT: I find it amusing that even the people that have responded to you so far, still haven't actually cited anything yet.
I don't understand this thought process. Java and Kotlin apps run just fine on Fuchsia (or so I have heard). Fuchsia is only relevant for lower layers of the stack. Notably device drivers.
I hear Happy New Year more than Happy Holidays
That’s a great point – clearly the demographic you’re sending to will influence the results.

The experiment was, however, about as controlled for general USA populous as we were able to do - big box retailer, drives most customer acquisition via SEM / SEO so these type of results should be duplicatable if your customers find you through search engines.
One of my developer refused to get a bigger screen (19' at the moment). Should I force him to upgrade ? :)
This project will only be funded if at least $25,000 is pledged by Wednesday Dec 29, 6:19am EST

At only $815 so far, they have a long way to go in half a day
I came to the same conclusion that I wanted to try out Pylons a few weeks ago right around the same time the repoze.bfg + Pylons merger was announced and just decided to jump into Pyramid. Recently I've been really impressed with the flexibility the platform offers allowing me to use all the libraries I had planned on and to make design decisions that I'm comfortable with. Initially there was quite a big learning curve as I was unfamiliar with using paste, what traversal was and if I should use it, best method to configure my app, etc... Initially this was my only real criticism, the level of indecision this flexibility instills in a noob, but since then the devs have been actively working on the docs to make them more beginner friendly and I've gotten some really great help in the irc channel. I'd say it's definitely worth taking a look if you were interested in Pylons.
I especially liked the "Have An Uncanny Ability To Say No".

Will keep a tag to this set and revisit it at least yearly. It's a good reminder of how to keep growing - and in the right direction.

Had at least one "should have said no" in the prior year. 6000 eur to visual planning from which we ended up using the logo only. Should have said no. :&
Imagine if Google had spent the last 4 years refining Google Answers instead of boxing it up.
da bears?
It's remind me the times when I was playing with Macromedia Flash MX
It's important to note that this is a rather controversial paper. For one, the authors aren't actually neolithic experts, they're (presumably otherwise excellent) engineers. They also don't get the dating right and fail to cite a wide range of literature relating the iconography at Gobekli Tepe to a wide variety of sites in the region like Jerf el Ahmar and Tell al-'Abr where it appears in more pedestrian contexts. Moreover, their argument relies on the extremely controversial and as-yet unsettled Younger Dryas Impact hypothesis. After assuming this (fine), they leap straight into assuming they understand both what the original authors were intending (completely unsubstantiated) and that these intentions were shared by disparate cultures across multiple continents and tens of thousands of years (mostly covered in a followup paper). This was egregious enough that many of the archaeologists working on Gobekli Tepe wrote a group paper [1] pointing out some of the methodological issues and problems with how their conclusions failed to follow from them.

As a disclaimer, I'm a big proponent of outsiders contributing to unrelated fields and do so myself as an archaeologist in tech. The way to do it is not by ignoring prior work done in the field, but instead by engaging with it constructively. These authors haven't really done that and it shows in the quality of this paper.

[1] http://doi.org/10.5281/zenodo.581724
Couldn't he gamble with them? Put one or two chips down at a time, keep the winnings as "clean" chips and gamble with the dirty ones until they're all gone?
It's most likely not the constellation itself, but the other mechanism:

https://en.wikipedia.org/wiki/EURion_constellation#Other_ban...

In particular, have a look at this:

http://www.cl.cam.ac.uk/~sjm217/projects/currency/
My recollection is probably a bit off, but IIRC, the FBI knowingly and repeatedly lied to the FISA court ("material misstatements") in order to obtain secret search warrants to spy on the Tump campaign based on opposition research which was directly funded by the Clinton campaign, who had hired a former MI6 spook to find or make up dirt who also happened to be working for the bureau and was secretly leaking everything to the press! There were basically no consequences for anyone involved, including the FBI. I wouldn't believe that story line in a movie.

The FBI continually goads citizens into being terrorists or on occasion, convinces them to kidnap a governor, then arrests them and claims victory! We could look a little further back in time to the aftermath of 9/11, and the role the CIA played in the invasions of Afghanistan and Iraq, or the even the FBI doing its best to destroy the civil rights movement.
Do you mean the pdf file?

The e-book version is based on html, so there are no multiple columns, and the text is flowable, searchable, resizable, etc.
I find it a bit nuts that people don't get it.

Where I live - in Sydney, Australia - it's generally understood that contractors/freelancers make more money than typical working stiffs. I think I would always be able to make more money as a freelancer. I would still be doing so, if I hadn't found a great job at a great company.

What puzzles me, though, is the purpose of this blog post. Surely anyone reading it already knows the score. :-)
I would suggest keeping a daily diary of what you eat, your energy level, your mood, how much you slept and your sleep quality (insomnia, hypersomnia), and any other symptoms or potential causes you'd like to track. A Google spreadsheet would probably work well. If you are disciplined and track good data, if after a year you haven't figured anything out yet, you've got a boatload of data to analyze and may be able to unlock the mystery yourself.
On a Windows/Hospital related note, I heard this antecdote in a class, any confirmation if true or source? Seems very plausible and likely.

During an operation, one of the OR monitoring devices went down because it was running on Windows and was neglected for some period of time, causing Windows to do an automatic reboot for a "Critical Windows Update."

Of course, seeing a necessary piece of OR equipment go down due to a Windows setting didn't make anyone happy, so the response was to remove automatic update from all of the Windows boxes in the Hospital. Not just mission critical ones, all of them: Secratary's machies, Nurse's machines, IT machines, etc. Fast forwood some months/years, no manual updates were done either, and with automatic ones turned off, a virus came across through a worker's computer and wiped out everything.

True or not, I still think it is a good story for how not to handle security issues.
In my use of the EVO battery life didn't seem that bad. A bit worse than the Nexus, but not a nightmare. I did run into the photo issue: got SD card errors when trying to save that would require rebooting the phone. Seems like a possible bug that a software upgrade could address.

Aside from these issues, the EVO's display makes it hard to go back to an N1. The display is gorgeous and the extra screen real estate makes typing via the soft keyboard significantly easier. Photos taken by the EVO are impressive as well: much better than the N1 or any smartphone I've ever seen.
Your PNG compressor is garbage.

PNG, 339 bytes: http://i.imgur.com/68vR8.png

Also don't forget that the path string will be gzipped (to around 220 bytes).
Yes, this is true, the dynamic language communities have compensated for the lack of a type system with explicit type checks (or type constraints) and lots of testing. But it's still nice to have a real type system (and I don't mean C or C++ or Java; those languages also have no type system). When I compile a Haskell project successfully, I have a reasonable belief that it's going to run to completion and at least produce some sort of result. The same is not true of Perl, even with lots of tests, my programs almost always die in the middle (during development) where a runtime type check or assertion fails.

The reality of programming is that all functions and variables have types. If you add 42 to "hello world", you get garbage. In dynamically typed languages, you keep the types in your mind -- you know that the variable you are adding 42 is a number. In statically typed languages, you tell the compiler. The second way lets the computer do some of the work for you (ensuring that if you use the variable like a string, your program won't compile), the first way requires you to do everything. If you aren't careful, you get the wrong answer or a runtime error.

I think dynamic typing was a nice way for the programming language community to realize that C's type system sucked, but it isn't the ultimate answer, it's just a stopgap. It's also good that people realized they needed to test their code automatically; but that works even better with statically-typed languages.

Anyway, I am not going to give up Perl anytime soon, but I secretly wish it wasn't dynamically-typed.
Yeah, I should have thought this through. I knew you kept them cool, and with a bit of thinking it should have been clear that you don't turn a superconducting coil off, since nothing's powering it... ;-)
It's a developer oriented site. Why would a non-developer care that it's down? The main outlets want the attention of the majority - so we don't get alerts when HN, Github, etc go down or get attacked but we do when Facebook drops for 15 minutes
...because others then can find out how many visitors your site gets? Or perhaps nastier things, like guessing id's?
I've been trying to asses the look of the sites I go to lately (mostly clean and simple ones). I like what you've done. Clean with just a touch of depth. I haven't consumed the content yet, but it looks tasty. I'm looking forward to trying the beta.
Judging by the upvotes, the comment was misread. The point was that it is trivial to extend the generalization to avoid verbose references and type names.
#51: Bookmark nixCraft, articles.slicehost.com & the Linode Library.
They're not fighting over Java, they're fighting over the JVM.
Java isn't worth fighting over.
That progress bar may not be tied to actual events, but it does give you a reasonably accurate view of the time remaining until the login window will appear-- probably more accurate than if the programmer guesses how much each startup phase is worth and the bar ends up moving erratically.
Well, the hebrew word: Torah, means "instruction" (תּוֹרָה).
So I guess that means if you forget the instruction,
you are certainly missing the mark.

http://en.wikipedia.org/wiki/Torah
>50% keeping a porn collection

I can only imaging what a teenager is able to amass these days with TB hard drives and what others might think when they go through it. From a security perspective if [they] suspect that [you] have a porn collection would it be prudent to keep a small and neutral porn collection somewhere easily found on their system? With the percentage being so high they (parents) might keep looking until they find something.
Considering he is suing many small companies, who prefer to settle rather than pay for a lawsuit, it's not clear he is doing a net service. A serial litigator has an economy of scale in terms of lawsuits. All but the largest companies can afford to keep lawyers on staff or to hire them regularly.

So as much as I'd like to applaud people who fight spam, I think this guy just found a legal niche to mess with small and legitimate companies. It's like the crippled person going around suing shops for lack of legal amenities (ramps, ramp angles, parking, toilets).
interesting, hadn't heard of it before. Apparently it was primarily for printing purposes

https://stackoverflow.com/questions/3380538/what-is-a-vertic...
And that's why I play Nethack on a public server, instead of locally. Removes these temptations.
fuck.. you have an agenda, i get it. i am not attacking you. i pay for films and art and music and other real stuff. i made a simple observation about the power dynamics of media sales. the fact that content producers are not noticing they are being fucked sideways by the distribution companies, killing their art to maintain their profits, while the ground is being pulled out from under them by the public. the market is collapsing and they are attacking their customers.

"This is a bit rich"
but it is still not what i am saying. its amoral, not moral/immoral!

"The need to and the costs of production.."
but that is the thing, if there is no market for it then you can't do shit. if the market is not willing to pay for the costs of production, you push the cost of production down, find another way to push costs up, or you just starve. this is not me telling you this. this is just how it is for everyone.

"In economics there is supply and demand.."
fair enough, i see we are saying the same thing here. tbh i just read your sentence as gibberish to impress how much you knew about economics. i understand the meaning if not the terminology, no need to be an arse.

"Well, now you know how I feel.."
to be fair, i knew how you felt. i was just trying to disabuse you of the notion that there is anything fair about work and pay. it is power pure and simple. that is, in fact, why some people get the 10x income, and some do the 1x work.

"In what sense do you consider yourself a producer?"
i am sorry, but i cannot help but read that as being a bit fucking condescending. so finding it difficult, but giving you the benefit of doubt, perhaps you are asking if i am a big p Producer? no. i am a designer. 1 x work for slightly less than 1x pay.. as it happens.
It’s increasingly almost the same, aside from very DOM/*ML rendering contexts, and getting more similar as time goes on. Which is good for portability but JS (ECMAScript/TC-39) is huge in itself, and the various compatible things in the JS runtime ecosystem (browsers/Node/Deno) is also huge. Node was historically more limited here but given how much the language itself is expanding they have to choose compat.
The takeaway here seems to be that black inventors in the northern United States, where there was ostensibly less racism, earned patents at nearly the same rate as every other race. Black inventors in the south, where the racism was extreme and overt, earned patents at about half that rate.

As people have pointed out on hn in the past, patents had a different purpose in the Golden Age than they do now. Corporations essentially outsourced their R&D to private inventors and then did their technology improvements by purchasing patents. This meant that black inventors had to deal with the extra risk of having their patents stolen by any of the white lawyers and professionals who were involved in the process. Getting compensated for developing ideas and prototypes was really running a gauntlet.

Quick story about one of my personal heroes, Granville Woods: He invented a multiplex telegraph that allowed two way communication from moving trains. Someone who worked for Thomas Edison filed for the patent before Woods could, but Woods ended up being able to use notes and witnesses to prove that he was first to invent. Edison later appealed the patent office ruling, but ultimately lost. He was impressed enough with Granny that he offered him a significant job at the Edison Company (Woods declined). Woods lived in the north, in Ohio. If he had been born in the south he might have ended up with nothing at all.
Parent said no commas or braces. He didn't say "all you have are record separators".

E.g.: a list:

- foo
- bar
- buz and other things besides

list of dicts:

persons:
- name: John Smith
age: 54
occupation: Obergruppenführer
- name: Frank Frink
age: 32
occupation: craftsman

(Those are already valid YAML iirc)
> it's been done before without funding, it can be done again.

What has been done, specifically? Do not compare the effort of IceWeasel (and the many mozilla-less forks of Firefox that came at that time: basically just keep a folder with different set of resources and some automated build with a few different variables) with the work of keeping a fork with code that needs be "frozen in time, except for backported CVE fixes". Not only it's a different type of job (the first can be mostly automated, the second requires an ongoing process and effort from highly specialized professionals) it was also required for legal reasons, so it was at best a hurdle and no actual benefit.

> I believe that the community would be better off if this existed.

Yet, you are not willing to contribute anything to make this happen. You'd be willing to reap the benefits from it, but not to actually put in any effort. Show some willingness to put skin in the game, otherwise all your "beliefs" are nothing but hot air.
Just woke up, saw this title, rubbed my eyes to make sure I wasn't seeing things—and then realized what type of cardinal this was!
> So maybe we should buy a few more tanks/ships/bombs than we need so that we don’t forget

Ironically most modern weapons programs do the exact opposite.

Costs increase.

So they cut orders.

Which just makes the per unit costs increase even more.

So they cut orders again.

Repeat until program fails.
...a jobs and pork program first and foremost, like...

...everything in USA military.

Have we won a war in your parents' lifetimes? Have any of our many military misadventures accomplished any of the goals cited as justification? Has anyone in the Pentagon ever been fired for spending too much money? Does the Pentagon even have any idea what it spends on what?

(The answer to all these questions is "no".)
So what do they use the money for if not actual software engineering? I have a feeling if people start digging they'll uncover a situation similar to Wikipedia.
That may be the case, but I think the "bugs" in humanity are biased towards not using nuclear weapons. I think that's a good thing.

For example it's very possible that a "Should I launch the nukes?" algorithm would've come up with a different answer than Stanislav Petrov did[1]. There's a similar story about US missileers disregarding a glitch in their own command and control system on Okinawa but the authenticity is suspect.

[1]: https://en.m.wikipedia.org/wiki/1983_Soviet_nuclear_false_al...
More anecdata - I did 500 startups in 2016 and used GCP credits, and did not have any problems getting them applied in a timely fashion. To be fair I was already a paying customer at that point (had a small VM or two running) but I did not get a sales up-sell or multi-week delay.
Storing fresh ingredients for all of those items takes a lot of space; a typical restaurant can't do it. Diners and do it by using canned ingredients from sysco.
And it was a lengthy discussion, with a More link at the bottom to get to the second page.
You should treat college homework and studying as a constrained optimization problem. Decide up front how many hours you're going to put in per weak and then figure out how to maximize your GPA within that limit. In the remaining time you can do whatever you want.
> What I said was that introverts are capable of overcoming their tendencies

I think the person above was pointing out that by saying that introverts need to "overcome" their tendencies, you are effectively saying that introverts have an issue that needs to be overcome.