Claim: The Dodecanese are a group of islands.

The Dodecanese -LRB- -LSB- doʊdɪkəˈniːz -RSB- Δωδεκάνησα , Dodekánisa , -LSB- ðoðeˈkanisa -RSB- , literally `` twelve islands '' -RRB- are a group of 15 larger plus 150 smaller Greek islands in the southeastern Aegean Sea , off the coast of Asia Minor -LRB- Turkey -RRB- , of which 26 are inhabited . Τhis island group generally defines the eastern limit of the Sea of Crete . They belong to the wider Southern Sporades island group .   The most historically important and well-known is Rhodes , which has been the area 's dominant island since Antiquity . Of the others , Kos and Patmos are historically the more important ; the remaining eleven are Agathonisi , Astypalaia , Kalymnos , Karpathos , Kasos , Leipsoi , Leros , Nisyros , Symi , Tilos , and Kastellorizo . Other islands in the chain include Alimia , Arkoi , Chalki , Farmakonisi , Gyali , Kinaros , Levitha , Marathos , Nimos , Pserimos , Saria , Strongyli , Syrna and Telendos .