Claim: The 46th largest population in the United States is New Orleans.

New Orleans -LRB- -LSB- nuː_ˈɔːrlᵻnz , _ - ˈɔːrli.ənz , _ - ɔːrˈliːnz -RSB- , or -LSB- ˈnɔːrlᵻnz -RSB- La Nouvelle-Orléans -LSB- la nuvɛlɔʁleɑ̃ -RSB- -RRB- is a major United States port and the largest city and metropolitan area in the state of Louisiana . The population of the city was 343,829 as of the 2010 U.S. Census . The New Orleans metropolitan area -LRB- New Orleans -- Metairie -- Kenner Metropolitan Statistical Area -RRB- had a population of 1,167,764 in 2010 and was the 46th largest in the United States . The New Orleans -- Metairie -- Bogalusa Combined Statistical Area , a larger trading area , had a 2010 population of 1,452,502 .   It is well known for its distinct French and Spanish Creole architecture , as well as its cross-cultural and multilingual heritage . New Orleans is also famous for its cuisine , music -LRB- particularly as the birthplace of jazz -RRB- , and its annual celebrations and festivals , most notably Mardi Gras , dating to French colonial times . The city is often referred to as the `` most unique '' in the United States .   New Orleans is located in southeastern Louisiana , straddling the Mississippi River . The city and Orleans Parish -LRB- paroisse d'Orléans -RRB- are coterminous . The city and parish are bounded by the parishes of St. Tammany to the north , St. Bernard to the east , Plaquemines to the south , and Jefferson to the south and west . Lake Pontchartrain , part of which is included in the city limits , lies to the north and Lake Borgne lies to the east .   Before Hurricane Katrina , Orleans Parish was the most populous parish in Louisiana . As of 2015 , it ranks third in population , trailing neighboring Jefferson Parish , and East Baton Rouge Parish .