Claim: True Blood's setting is Louisiana.

True Blood is an American dark fantasy horror  television series produced and created by Alan Ball and based on The Southern Vampire Mysteries series of novels by Charlaine Harris .   The series revolves around Sookie Stackhouse -LRB- Anna Paquin -RRB- , a telepathic waitress living in the rural town of Bon Temps , Louisiana , two years after the invention of a synthetic blood that has allowed vampires to `` come out of the coffin '' and allow their presence to be known to mankind . Now they are struggling for equal rights and assimilation , while anti-vampire organizations begin to gain power . Sookie 's world is turned upside down when she falls in love with 173-year-old vampire Bill Compton -LRB- Stephen Moyer -RRB- and for the first time must navigate the trials , tribulations and terrors of intimacy and relationships .   The show was broadcast on the premium cable network HBO , in the United States , and was produced by HBO in association with Ball 's production company , Your Face Goes Here Entertainment . The series premiered on September 7 , 2008 and concluded on August 24 , 2014 , comprising seven seasons and 80 episodes . The first five seasons received highly positive reviews , and both nominations and wins for several awards , including a Golden Globe and an Emmy .