Claim: Resident Evil's protagonist is portrayed by Milla Jovovich.

Alice is a fictional character in the Resident Evil film series , which is loosely based on the video game series of the same name . Though she is not a character in the game series , she does eventually interact with a number of characters from the games , including Jill Valentine , Claire Redfield , Carlos Olivera , Chris Redfield , Leon S. Kennedy , Barry Burton , Ada Wong , Albert Wesker and Nemesis . Alice , portrayed by Milla Jovovich , plays the principal role in each film , the storylines all somewhat revolving around her and the struggle with the Umbrella Corporation . Apart from the films , she appears in the film 's novelizations where her background is explained , with the surname `` Abernathy '' attached , and in the newspaper promotion of the second film , where `` Janus Prospero '' is used as her real name . However , in the sixth and final film her real name was revealed to be Alicia Marcus .