jimnoneill/paper-to-field-training huggingface dataset:
Siep STUURMAN, François Poulain de la Barre and the Invention of Modern Equality, Cambridge (Mass.), Harvard University Press, 2004, x-361 pages.

Simone de Beauvoir a beau avoir placé en épigraphe du Deuxième sexe une citation de François Poulain de la Barre (1647-1723), cet écrivain cartésien, qui est l’auteur de trois traités féministes essentiels, reste pour ainsi dire inconnu. Dans son ouvrage, François Poulain de la Barre and the Invention of Modern Equality, Siep Stuurman entend lui restituer toute son importance, non seulement dans l’histoire du féminisme et du genre, mais aussi dans celle de la critique sociale et politique. C’...

Topic: European Political History Analysis
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
RESEARCH Open Access BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

Background: Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (BC). After the oncogenic translocation, the BCR/ABL1 gene is under the transcriptional control of BCR promoter but the molecular mechanisms involved in the regulation of oncogene expression are mostly unknown. Methods: A region of 1443bp of the functional BCR promoter was studied for transcription factor binding sites through in-silico analysis and Chromatin Immunoprecipitation experiments. BCR and BCR/ABL1 expression levels were analysed in CML cell lines after over-expression or silencing of MYC transcription factor. A luciferase reporter assay was used to confirm its activity on BCR promoter. Results: In the present study we demonstrate that MYC and its partner MAX bind to the BCR promoter, leading to up-regulation of BCR and BCR/ABL1 at both transcriptional and protein levels. Accordingly, silencing of MYC expression in various BCR/ABL1 positive cell lines causes significant downregulation of BCR and BCR/ABL1, which consequently leads to decreased proliferation and induction of cell death. Conclusions: Here we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer. Since MYC is frequently over-expressed in BC, this phenomenon could play a critical role in BCR/ABL1 up-regulation and blast aggressiveness acquired during CML evolution.

Topic: Chronic Myeloid Leukemia Treatments
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Cranial nerve pathology in multiple system atrophy (MSA): Implications for the in vivo evaluation of disease (P1.271)

OBJECTIVE: To assess alpha-synuclein (AS) pathology at the entry (Redlich-Obersteiner) zone of the glossopharyngeal/vagus nerves (CNs IX/X) in MSA, Parkinson disease (PD) and Lewy body disease (LBD), as well as AS deposition in olfactory bulb and tract (OB/CN I) and the optic pathway in MSA. BACKGROUND: Patients with PD and LBD may have AS lesions in extra-CNS tissues and OB/CN I, offering potential for in vivo biopsy confirmation of disease. Involvement of cranial nerves in MSA is less well known. DESIGN/METHODS: AS-immunoreactive lesions across the entry zone of CNs IX/X were evaluated in pathologically confirmed autopsied patients, including 16 with MSA (median age 67 years) and 9 with PD or LBD (median age 82 years). OB/CN I involvement was evaluated in 6 MSA patients (median age 63 years). Glial cytoplasmic inclusions (GCIs) were assessed in the optic chiasm and tract of 18 MSA patients (median age 67 years). RESULTS: Seven of 9 PD/LBD cases (77.8[percnt]) showed AS lesions at the CN IX/X entry zone, typically as multiple strongly immunoreactive axons; this was not seen in MSA (Fisher exact p = 0.00002). In contrast, MSA patients demonstrated AS pathology in the OB/CN I as GCIs (100[percnt]), neuronal inclusions (83.3[percnt]) and LB-like inclusions and neurites (33.3[percnt]). GCIs in optic pathway were frequent in MSA (88.9[percnt]), ranging from 1-9 GCIs per 10x microscopic field, and GCI density was independent of disease duration. CONCLUSIONS: The entry zone of CNs IX/X lacks AS pathology in MSA, suggesting that extra-CNS tissues subserved by these peripheral nerves would not harbor diagnostic AS lesions on premortem biopsy. MSA patients have pathologic involvement of OB/CN I, including LB-like inclusions and neurites. Further, GCIs are present in the optic pathway of many MSA patients suggesting the possibility of AS deposition in the retinal ganglion cell layer.

Topic: Parkinson's Disease Mechanisms and Treatments
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Recreating the Research University: Cutting the Gordian Knot.

This paper consists of a speech delivered on the occasion of the 100th anniversary of the University of Rhode Island (URI) that proposes a nwa structure for the future of that institution. The paper opens by describing the questions and discussion raised in the past year by the onset of the anniversary. Also touched on is the early history of the university, a reflection on the changing nature of global relations and national economic forces, and the increased importance of knowledge of the economic picture, which suggests changes in the structure and role of universities. In the course of a discussion of the importance of educational quality the Total Management approach to institutional organization is proposed as a desirable model and the current movement at URI to adopt this program and to establish an Academy for Quality that will research and teach the various elements of quality management to and for the university community is described. A consideration of the conflict between the needs of research institutions and lack of funding culminates in a proposal to solve the conflict between research and lack of funding by reorganizing the institution into eight faculty and student research centers conceptualized broadly as teams with a mission and implementing many of the most effective practices for student

Topic: Research, Science, and Academia
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Comprehensive knockout analysis of the Rab family GTPases in epithelial cells

The Rab family of small GTPases comprises the largest number of proteins (∼60 in mammals) among the regulators of intracellular membrane trafficking, but the precise function of many Rabs and the functional redundancy and diversity of Rabs remain largely unknown. Here, we generated a comprehensive collection of knockout (KO) MDCK cells for the entire Rab family. We knocked out closely related paralogs simultaneously (Rab subfamily knockout) to circumvent functional compensation and found that Rab1A/B and Rab5A/B/C are critical for cell survival and/or growth. In addition, we demonstrated that Rab6-KO cells lack the basement membrane, likely because of the inability to secrete extracellular matrix components. Further analysis revealed the general requirement of Rab6 for secretion of soluble cargos. Transport of transmembrane cargos to the plasma membrane was also significantly delayed in Rab6-KO cells, but the phenotype was relatively mild. Our Rab-KO collection, which shares the same background, would be a valuable resource for analyzing a variety of membrane trafficking events.

Topic: Cellular transport and secretion
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Figure 2 from MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer

&lt;p&gt;MYBL2 expression and activity is enriched in human NEPC and NE-like mouse models. &lt;b&gt;A,&lt;/b&gt; Venn diagram integrating the differential gene expression (DEG) list from PBCre4:Ptenf/f (SKO) vs. PBCre4:Ptenf/f:Rb1f/f (DKO) mouse models, human NEPC vs. adenocarcinoma samples, and patient-derived xenografts of LuCaP obtained from human patients with NEPC vs. patients with adenocarcinoma shows that the three independent datasets shared 1,516 genes (left). GSEA of the 1,516 shared genes indicates that the fischer_dream_targets genes may be involved in the regulation of CRPC-AI development (right). All the pathways listed are statistically significant with &lt;i&gt;P&lt;/i&gt; &lt; 0.05. &lt;b&gt;B,&lt;/b&gt; Bar and box plot summarizing the MYBL2 expression level in human patients with prostate cancer at different stages of the disease progression. &lt;b&gt;C,&lt;/b&gt; Correlation analysis mouse and (&lt;b&gt;D&lt;/b&gt;) human samples indicate that enrichment of MYBL2 transcriptional function is highly associated with NE and ESC gene signatures in NEPC models and patient samples compared with their adenocarcinoma counterparts. WT, wild type.&lt;/p&gt;

Topic: Prostate Cancer Treatment and Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Comparative Evaluation of Ultraviolet and Visible Light Transmittance through Prescriptive Ophthalmic Minus Lenses

<h2><strong>Background: </strong>Wearing spectacles is the most common approach in correcting the refractive errors worldwide. Due to harmful effects of overexposure to solar ultraviolet radiations, the usage of multi-layer coatings in ophthalmic lenses has recently been increased. These lenses can reduce the reflections and hence increase the transmission of visible light; they can also decrease the transmission of ultraviolet rays. This study aims to compare the transmission of ultraviolet (A and B) and visible rays through coated and uncoated prescriptive ophthalmic plastic lenses.</h2> <strong>M</strong><strong>aterials and Methods: </strong>In this study, 39 minus non-photochromic multi-coated white plastic single-vision lenses; 9 similar lenses but without any coatings were assessed by spectral transmittancemeter for evaluation of the transmission of visible and ultraviolet rays. <strong>R</strong><strong>es</strong><strong>ults: </strong>The transmission of visible light was 97.9%±1.07% for coated lenses and 93.5%±0.54% for lenses without coating. Ultraviolet-A transmission was 12.15%±8.02% for coated lenses compared to 66.27%±23.92% in lenses without coating. The transmission of ultraviolet-B rays was 1.21%±0.4% and 23.0%±15.97% for lenses with and without coatings, respectively. <strong>C</strong><strong>onclusion: </strong>The transmission of visible light was significantly higher in multi-coated lenses compared to uncoated samples; whereas the transmissions of ultraviolet rays in multi-coated lenses were significantly lower than uncoated ones. Therefore, it is recommended that, except for particular cases, prescribed lenses be equipped with this multi-layer coating.

Topic: Ocular Surface and Contact Lens
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
KEBIJAKAN PENGEMBANGAN INFRASTRUKTUR TRANSPORTASI LAUT PADA DINAS PERHUBUNGAN KABUPATEN MUNA BARAT

This study aims to determine the policies carried out by the transportation agency in an effort to develop marine transportation infrastructure and the benefit that can be obtained in the development of the marine transportation infrastructure.The informant in this study consisted of ahead of the department transportation districts Muna Barat, secretary department transportation districts Muna Barat, and head of development and safety department transportation districts Muna Barat.The results of this study indicate that policy department transportation districtsMuna Barat in development infrastructure water transportation seen from three policies. First, infrastructure investment is considered good seen from the collaboration done with several parties which have to invest several ships that have been operated in several ports which exist in Muna Barat. Second, development infrastructure port assessed already enough good seen from development docks and port which exists in islands small in region districts Muna Barat. Third, expansion capacity port assessed already good seen from additions long from port people Latawe and port people Pajala and additions large at the port Tondasi. Benefit development infrastructure port covers economic growth, job creation, and development of economic national and regional. If seen from the fact that is there can be it is said that as is development port or infrastructure water transportation then very have a positive impact on economic growth, job creation, and development economic national and regional because the port is an asset regional and country very important in support smooth turnaround the wheel economic remembering Indonesia is archipelago state.

Topic: Coastal Management and Development
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
ChemInform Abstract: Contributions on the Thermal Behavior of Anhydrous Phosphates. Part 9. Synthesis and Crystal Structure of Cr6(P2O7)4. A Pyrophosphate Containing Di‐ and Trivalent Chromium.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Thermal and Kinetic Analysis
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Isolation of a Ca2+ carrier from calf heart inner mitochondrial membrane.

A protein has been isolated from calf heart inner mitochondrial membrane with the aid of an electron paramagnetic resonance (EPR) assay based on the relative binding properties of Ca2+, Mn2+, and Mg2+ to the protein. The molecular weight of this protein has been estimated to be about 3000 by urea/sodium dodecyl sulfate-gel electrophoresis and amino acid analysis. The isolated protein has been shown to have high affinity and high specificity for Ca2+ (Jeng, A. Y., Ryan T. E., and Shamoo, A. E. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 2125-2129). However, the protein was found to be contaminated with a large amount of phospholipids. There are 150 mol of phospholipids associated with each mole of the protein. The protein is delipidated using Sephadex LH-20 column chromatography. The contaminating phospholipids can be reduced to 0.1 mol of phospholipids/mol of protein. There are no detectable free fatty acids, hexosamines, or sialic acids associated with the delipidated protein. This protein is named "calciphorin," meaning calcium ionophore protein.

Topic: Mitochondrial Function and Pathology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Performatives and descriptions

The purpose of this article is to outline a schematic system for describing texts or “discourses” with respect to discourse function. In this system the concepts of performative and of descriptive discourse function take a central position. Provisional explicate for the said two concepts are introduced. A special sort of performative is identified, viz. statements; the concept of statement is to function as a pragmatic counterpart to that of description. An examination and comparison is made of the requirements which the communication context of a discourse has to fulfil in order that this latter qualify as a performative in general or as a statement. Then the question is considered how a performative and a descriptive discourse can be “justified” or shown to be adequate. Eventually the aforesaid descriptive system is introduced, and the role is examined which the explicata of performative and descriptive discourse function may play in the philosophy of science and in axiology.

Topic: Linguistics and Discourse Analysis
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Dynamics of Military Rule in Black Africa

This chapter focuses on the political pushes and pulls that will influence military regimes in sub-Saharan Africa during the latter half of the 1980s. The methodology that underlies what follows is simple. The chapter examines factors that impinge strongly upon the "typical" soldier-ruler and seem likely to persist into the future more or less as constants. The uniformed leader who has seized power in the typical sub-Saharan country will find himself at the helm of a leaky ship of state. Weak institutions, a sluggish economy, and a fractionated society characterize the domestic environment, while external forces, particularly global economic currents, exert an internal impact largely beyond the control of the government. The insecure soldier-politician will instead immediately attempt to surround himself with advisers who can be trusted, competence being a far lesser consideration than loyalty. Military capabilities are likely to sutler from the military ruler's efforts to keep potential challengers from developing power bases within the armed forces.

Topic: Global Peace and Security Dynamics
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
The Use of Fruits and Seeds by Ants in the Atlantic Forest of Southeast Brazil<sup>1</sup>

ABSTRACT Given the abundance of litter‐foraging ants and fallen fleshy diaspores on the floor of tropical forests, interactions involving them should be common and may render important consequences for the biology of the diaspores. In this study, we surveyed the interactions between ants and non‐myrmecochorous diaspores along a 5‐km transect in a lowland Atlantic rain forest of southeast Brazil. A diaspore is defined as any seed, fruit, or infructescence that constitutes the unit of dispersal of the plant. During two years of monthly samplings of naturally fallen diaspores, 886 ant– diaspore interactions involving 36 ant species and 56 different species of diaspores (range = 0.05–29.5 g) were recorded. The number of interactions was significantly and positively correlated with rainfall but not with mean temperature. The number of ant species recorded in the interactions was positively associated with both rainfall and temperature. Lipid‐rich diaspores attracted a larger ant assemblage than those with lower contents of lipids. The seasonal pattern for ant‐diaspore interactions in the Atlantic rain forest is predicted by well known seasonal patterns in ant activity and diaspore production. Other factors that also may affect the observed pattern are the massive and episodic fruiting of some plant species in which diaspores are especially attractive to ants, and a preference for lipid‐rich arillate seeds. Interactions between ants and fallen non‐myrmecochorous diaspores may be especially common in lowland rain forests in which the abundance of ants is coupled with the year‐round availability of fleshy diaspores.

Topic: Insect and Arachnid Ecology and Behavior
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Positivism and Nationalism in 19<sup>th</sup> Century France and Mexico

Abstract This article explores the relationship between positivism and nationalism in 19 th century France and Mexico, arguing that positivism cannot be understood without considering it in close relation to the rise of collectivistic and civic nationalism in each society. To elite intellectuals in both France and Mexico, positivism seemed to resolve the apparent chaos generated by the political‐conceptual revolution that nationalism had given rise to, and to provide the background to an historical narrative that served nationalist aims, by seeming to assure the ultimate triumph of the nation.

Topic: Historical Studies and Socio-cultural Analysis
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences
Supplementary Figure 3 from Expression of Leukemia-Associated Fusion Proteins Increases Sensitivity to Histone Deacetylase Inhibitor–Induced DNA Damage and Apoptosis

&lt;p&gt;PDF file - 3534K, The effects of PLZF-RARα and vorinostat on DNA damage and cell cycle regulators.&lt;/p&gt;

Topic: Histone Deacetylase Inhibitors Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Massive MIMO Channel Prediction Using Machine Learning: Power of Domain Transformation

To compensate the loss from outdated channel state information in wideband massive multiple-input multipleoutput (MIMO) systems, channel prediction can be performed by leveraging the temporal correlation of wireless channels. Machine learning (ML)-based channel predictors for massive MIMO systems were designed recently; however, the time overhead to collect a large amount of training data directly affects the latency of the system. In this paper, we propose a novel ML-based channel prediction technique, which can reduce the time overhead to collect the training data by transforming the domain of channels from subcarrier to antenna in wideband massive MIMO systems. Numerical results show that the proposed technique can not only reduce the time overhead but also give additional performance gain compared to the ML-based channel prediction techniques without the domain transformation.

Topic: Advanced MIMO Systems Optimization
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Mycorrhizal responsiveness to different phosphorus levels on yield attributes and mycorrhizal colonization of groundnut genotypes

This study examined P bioavailability, groundnut response to applied P and compared P management strategy with AM fungal treatment combinations. A field experiment was carried out at North eastern agro climatic zone of Tamil Nadu during 2018 and the experimental soil was pale brown sandy loam in texture (TypicHaplustalf). The treatments consisted of four levels of phosphorus viz., P0, P25, P50 and P75 kg/ha. The availability of P was investigated in the presence (V1) and absence (V0) of AM Fungi. Two genotypes namely VRI-2 (Vridhachalam-2) and G-5 (Gujarat-5) were selected for P growth study in the experiment. The results obtained from the study indicated that, AM inoculated plot was superior in yield potential than uninoculated plots. The treatments showed significant effect on growth and yield of groundnut varieties. The interaction effect of P levels and AM inoculation on growth and yield of groundnut genotypes were significant.

Topic: Plant nutrient uptake and metabolism
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
System Design of a Mobile Application to Support Foreigners Staying in Japan at the Time of a Disaster

Various natural disasters occur all over the world. Under such circumstances, research is being actively conducted to predict natural disasters and reduce the damage caused by disasters. In addition, the development of mobile applications for obtaining and sharing information in the event of a disaster is also active. Japan is a country where disasters such as earthquakes, typhoons, heavy rains, and floods occur almost every year, and technological development and service operations to mitigate the damage are active. In Japan, social media, especially Twitter, is used as an effective way to collect and share information at the time of a disaster. However, most of the disaster information systems are supposed to be used by Japanese people, and most of the information distributed during a disaster is in Japanese. In this paper, we consider the system design of a mobile application to support foreigners staying in Japan in the event of a disaster.

Topic: Public Relations and Crisis Communication
Subfield: Communication
Field: Social Sciences
Domain: Social Sciences