jimnoneill/paper-to-field-training huggingface dataset:
Comparison of the Performance of Two Commercial Genome-Wide Association Study Genotyping Platforms in Han Chinese Samples

Abstract Most genome-wide association studies to date have been performed in populations of European descent, but there is increasing interest in expanding these studies to other populations. The performance of genotyping chips in Asian populations is not well established. Therefore, we sought to test the performance of widely used fixed-marker, genome-wide association studies chips in the Han Chinese population. Non-HapMap Chinese samples (n = 396) were genotyped using the Illumina OmniExpress and Affymetrix 6.0 platforms, whereas a subset also were genotyped using the Immunochip. Genotyped markers from the Affymetrix 6.0 and Illumina OmniExpress were used for full genome imputation based on the HapMap 2 JPT+CHB (Japanese from Tokyo, Japan and Chinese from Beijing, China) reference panel. The concordance between markers genotypes for the three platforms was very high whether directly genotyped or genotyped and imputed single nucleotide polymorphisms (SNPs; &amp;gt;99.8% for directly genotyped and &amp;gt;99.5% for genotyped and imputed SNPs, respectively) were compared. The OmniExpress chip data enabled more SNPs to be imputed, particularly SNPs with minor allele frequency &amp;gt;5%. The OmniExpress chip achieved better coverage of HapMap SNPs than the Affymetrix 6.0 chip (73.6% vs. 65.9%, respectively, for minor allele frequency &amp;gt;5%). The Affymetrix 6.0 and Illumina OmniExpress chip have similar genotyping accuracy and provide similar accuracy of imputed SNPs. The OmniExpress chip however provides better coverage of Asian HapMap SNPs, although its coverage of HapMap SNPs is moderate.

Topic: Genetic Associations and Epidemiology
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Emotional states of mothers and behavior of the child during minor surgery].

The objectives of this descriptive correlational study were to measure the degree of fear-anxiety in mothers and in their children who were having minor surgery, and then to verify if there was a relationship between these two variables. Other variables examined were: child's age, rooming-in, premedication and child's experience with surgery. Fifty (50) mothers described their emotional states both on the day before and during the surgery. Fifty (50) children between the ages of two (2) and ten (10) years old were observed at five different times (one hour preoperatively, leaving for the OR, pre-induction, coming back to the room and one hour post-operatively). Their behaviours were noted on a new scale, the ECEO: Echelle des comportement de l'enfant opéré. This scale was developed to describe the behaviour of children experiencing fear, anxiety and pain. Results show that the mother's fear-anxiety score was significantly higher during the surgery than before it (t df.49 = 3.77, p < 0.001). Rooming-in significantly affected mothers' emotional states (F = 4.07, p < 0.05). Younger children were more affected than older ones; they also showed more distress when the mother was present (t df.49 = 5.31, p < 0.001). Rooming-in contributed significantly to the child's stress score; children whose mother roomed-in at least one night showed more distress behaviours than children whose mothers did not room-in (t df.48 = 2.03, p < 0.05). A correlation was found between the degree of mothers' fear-anxiety and the children's fear-anxiety-pain score or distress behaviours (r = .28, p < 0.05). A strong relationship was established between the total distress score of the child and his or her score when the mother was present (r = .81, p < 0.01). These results support the theory of social referencing: the child is influenced greatly by the mother's emotional state and he refers to her for the interpretation of events provoking anxiety. Therefore, nurses should inform and support mothers, especially those who are rooming-in; they should also make more use of parents in the preparation and the management of the child for surgery. The development and validation of an instrument measuring fear-anxiety-pain in younger children will facilitate evaluation of the effect of surgery or other procedures on the child, and the planning adequate interventions.

Topic: Child and Adolescent Health
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Theoretical aspects of spin-spin couplings

Chemical shifts (δ), direct (D) and indirect (J) spin-spin couplings as well as relaxation time constants are the most important parameters in nuclear magnetic resonance spectroscopy (NMR). The measurement and analysis of these parameters give detailed insight in the property of molecules. Numerous ...

Topic: Molecular spectroscopy and chirality
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Analytical Review of Reports from Pasteur Institutes on the Results of Anti-Rabies Treatment.

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal

Topic: Rabies epidemiology and control
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
The Galaxy Cluster Abell 3581 as seen by Chandra

We present results from an analysis of a Chandra observation of the cluster of galaxies Abell 3581. We discover the presence of a point-source in the central dominant galaxy which is coincident with the core of the radio source PKS 1404-267. The emission from the intracluster medium is analysed, both as seen in projection on the sky, and after correcting for projection effects, to determine the spatial distribution of gas temperature, density and metallicity. We find that the cluster, despite hosting a moderately powerful radio source, shows a temperature decline to around 0.4Tmax within the central 5 kpc. The cluster is notable for the low entropy within its core. We test and validate the xspec projct model for determining the intrinsic cluster gas properties.

Topic: Stellar, planetary, and galactic studies
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Nonequilibrium spin noise and noise of susceptibility

We analyze out-of-equilibrium fluctuations in a driven spin system and relate\nthem to the noise of spin susceptibility. In the spirit of the linear response\ntheory we further relate the noise of susceptibility to a $4$-spin correlation\nfunction in equilibrium. We show that, in contrast to the second noise (noise\nof noise), the noise of susceptibility is a direct measure of non-Gaussian\nfluctuations in the system. We develop a general framework for calculating the\nnoise of susceptibility using the Majorana representation of spin-1/2\noperators. We illustrate our approach by a simple example of non-interacting\nspins coupled to a dissipative (Ohmic) bath.\n

Topic: Quantum and electron transport phenomena
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Successful Cyclosporine Treatment in a Case of Amicrobial Pustulosis Associated with Immunological Abnormalities

Amicrobial pustulosis associated with autoimmune diseases (APAD) is a clinical entity which was described only recently and few cases are reported in the literature. This condition is characterized by recurrent acute onset with pustular lesions predominantly involving skin folds, genitals, scalp and external auditory canals of young women. The etiopathogenesis of APAD is unknown and the most effective therapeutic treatment seems to be systemic corticosteroids. We describe the case of a 16-year old female patient suffering from APAD successfully treated with cyclosporine A.

Topic: Autoimmune and Inflammatory Disorders
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Uji Efektivitas Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale L.) Sebagai Analgetik Pada Tikus Putih (Rattus norvegicus)

Pain is a defense mechanism of the body and caused by tissue damage to the body due to injury, accident or medical action. Traditionally, cashew leaves were used in curing inflammation, pain, toothache, wound healing, rheumatism as well as dysentery. This study aims to determine the effectiveness of analgetic power of cashew leaf ethanol extract (Anacardium occidentale L.) in white rats (Rattus norvegicus). The research conducted is experimental research, with chemical excitatory methods. The test animals were divided into 5 groups with each treatment of 3 mice. Group I Na CMC 1%, group II Paracetamol, group III cashew leaf ethanol extract 10%, group IV cashew leaf ethanol extract 20%, and group V cashew leaf ethanol extract 40% given orally. Pain inductors are 1% induced acetic acid intraperitonially. Observed the amount of mice geliat for 1 hour and calculated percent analgetic power. The results obtained in this study have properties as analgetics with analgetic power concentration of 10%: 82.73%, concentration of 20%: 84.89%, and concentration of 40%: 88.48%.

Topic: Medicinal Plant Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Synthesis of Ni Nanochains with Various Sizes: The Magnetic and Catalytic Properties

A series of pure Ni thin chains with particle diameters ranging from 15 to 80 nm were successfully synthesized by a wet chemical method. Magnetization measurements for the Ni chains reveal that the saturation magnetization increases and the coercivity decreases with increasing particle diameter. The magnetization reversal mechanism of both the samples with a diameter of 30 and 50 nm can be described by the model of "chain of spheres". Using the fanning mode, the calculated coercivities and the remnant ratios agree well with the experimental results. Surprisingly, the coercivity is greatly enhanced, reaching as high as 790 Oe at T = 5 K for the Ni chains with a diameter of ∼15 nm, which are composed of single-crystal particles. Meanwhile, in the degradation of pentachlorophenol (PCP) solutions with Fe0 nanoparticles as reducing agents, Ni nanochains with a diameter of ∼80 nm were added, and the results indicate that the sample could serve as a good catalyst in dechlorination systems.

Topic: Nanomaterials for catalytic reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Two Manuscripts Identified as One Parma 154 + Par. Gr. 2821

414 nificant than his application of the wife's name (... yvvo ûè «v University of MELBOURNE K. J. McKAY TWO MANUSCRIPTS IDENTIFIED AS ONE PARMA 154 + PAR. GR. 2821 In my study of the Triclinian recensions of Aeschylus and the problems connected with early Triclinian working-copies (Studies in the Scholia on Aeschyl2ts I, forthcoming) I have discussed the MS Parma, Fondo Parmense 154 which contains the Euripidean triad with a metrical commentary, and Par. gy. 2821 which contains the Aristophanic triad with a similar metrical commentary. I have pointed out that both commentaries must be regarded as the work

Topic: Classical Antiquity Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Effect of chronic kidney disease on the association between hyperuricemia and new‐onset hypertension in the general Japanese population: ISSA‐CKD study

Abstract We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population. We included 7895 participants aged ≥30 years from the ISSA‐CKD study, a population‐based retrospective cohort study that used annual health check‐up data of residents from Iki Island, Japan. After the exclusion of 1881 with l &lt; 1‐year follow‐up, 2812 with hypertension at baseline, and 165 with missing information on SUA, a total of 3037 participants were enrolled in this analysis. Participants were divided into four groups according to the quartiles of SUA level at baseline, and multivariable‐adjusted hazard ratios for new‐onset hypertension were calculated. Stratified analyses were performed for each subgroup (defined by sex, age, alcohol intake, and CKD) to assess the interaction effects. During a mean follow‐up period of 4.4 years, 943 participants developed hypertension. The first quartile group was set as the reference group, and the multivariable‐adjusted hazard ratios (95% confidence interval) for new‐onset hypertension were 1.11 (0.90–1.36) in the second quartile, 1.25 (1.02–1.54) in the third quartile, and 1.35 (1.07–1.70) in the fourth quartile compared with those in the reference group ( p = .007 for trend). The stratified analyses showed that the association between SUA and hypertension was significantly stronger in participants with CKD than in those without CKD ( p = .035 for interaction). SUA level is an independent risk factor for new‐onset hypertension. This tendency was significantly stronger in participants with CKD.

Topic: Gout, Hyperuricemia, Uric Acid
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Rhodium(<scp>i</scp>) complexes with carborane-substituted <i>P</i>,<i>N</i> ligands: investigations of electronic structure and dynamic behaviour

Two distorted square-planar Rh<sup>I</sup> complexes (<bold>1</bold> and <bold>2</bold>) were obtained from [{RhCl(η<sup>4</sup>-cod)}<sub>2</sub>] and the respective <italic>P</italic>,<italic>N</italic> ligands.

Topic: Boron Compounds in Chemistry
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Positive Feedback II: How Dust Coagulation inside Vortices Can Form Planetesimals at Low Metallicity

The origin of planetesimals ($\sim$100 km planet building blocks) has confounded astronomers for decades, as numerous growth barriers appear to impede their formation. In a recent paper we proposed a novel interaction where the streaming instability (SI) and dust coagulation work in tandem, with each one changing the environment in a way that benefits the other. This mechanism proved effective at forming planetesimals in the fragmentation-limited inner disk, but much less effective in the drift-limited outer disk, concluding that dust traps may be key to forming planets at wide orbital separations. Here we explore a different hypothesis: That vortices host a feedback loop in which a vortex traps dust, boosting dust coagulation, which in turn boosts vortex trapping. We combine an analytic model of vortex trapping with an analytic model of fragmentation limited grain growth that accounts for how dust concentration dampens gas turbulence. We find a powerful synergy between vortex trapping and dust growth. For $α\le 10^{-3}$ and solar-like metallicity this feedback loop consistently takes the grain size and dust density into the planetesimal formation region of the streaming instability (SI). Only in the regime of strong turbulence ($α\ge 3\times 10^{-3}$) does the system often converge to a steady state below the SI criterion. The combination of vortex trapping with dust coagulation is an even more powerful mechanism than the one involving the SI. It is effective at lower metallicity and across the whole disk -- anywhere that vortices form.

Topic: Astrophysics and Star Formation Studies
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
INFLUENCE OF THERMAL PROCESSING ON THE NUTRITIONAL COMPOSITION, AMINO ACID PROFILE AND SENSORIAL CHARACTERISTICS OF BISCUITS PRODUCED FROM WHEAT-DEFATTED MELON SEED FLOUR BLENDS

The study was conducted to investigate the influence of thermal processing on the nutritional composition, amino acid profile and sensorial characteristic of biscuits produced from wheat flour-defatted melon flour blends from toasted and raw melon seeds.The melon seeds was toasted at 160 0 C for 20mins and the other portion left untreated.The treated and untreated melon seed was defatted using n-Hexane and grinded into flour.The flour from the defatted roasted and raw melon seed flour was incorporated with wheat flour at 4 percentage ratio (100:0, 95:5, 90:10, 80:20, 70:30) respectively.Nine (9) samples of biscuit was formulated with other ingredients to produce biscuits according to the standard method and subjected to statistical evaluation in complete randomized design using statistical Product for Social Services version 21.The means were separated using Duncan Multiple test range at (p<0.05).The inclusion of the defatted melon flour from the untreated (raw) and toasted melon significantly increased (p<0.05) the moisture (1.78-3.87%), protein (13.47 to 21.05 %), ash (2.04 to 2.72 %), fat (9.34-12.73%)and reduced (74.92-56.86%) carbohydrate content of the biscuits.The amino acid profile of the biscuits showed significant (p<0.05)difference.The amino acid values varied significantly (p<0.05) and showed increase with increase in the substitution of the defatted melon flour.The amino acid ranged from leucine (7.48 to 9.18 g/100 g), lysine (4.78-9.18g/100g), Histidine (1.89-2.38 g/100g), Arginine (3.12-5.02g/100g) and 10.48-12.80g/100g in glutamic acid respectively.The physical analysis showed significant (p < 0.05) difference among the biscuit samples.The study showed that substitution of wheat flour with defatted raw and toasted defatted melon flour at a ratio of 95:5 and 90:10 yielded the most acceptable biscuits in all the sensory attributes assessed.This implies that biscuits produced from this composite blend contain sufficient amounts of protein, fat, fiber and carbohydrate.Hence, they can serve as relief for malnutrition.

Topic: Phytase and its Applications
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Genetics of Tourette syndrome and related disorders

This chapter focuses on alcohol dependence (alcoholism), because the diagnosis is more reliable and because most of the genetic data focus on dependence. The earliest genetic association studies in alcoholism were candidate gene studies targeting coding variations in the genes that metabolize alcohol. Certain variations in alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH) genes have very strong effects on the risk for alcoholism. Variations in other genes appear to have a much smaller effect on risk. Linkage studies and their follow-up, along with candidate gene studies and genome-wide association studies (GWAS), are beginning to fill the gaps. Initial findings must be confirmed in independent studies, and much work remains to elucidate the mechanisms involved. The future will involve studies of epigenetic factors, copy number variants, and gene expression, as well as tests for rare variants of large effect in specific families.

Topic: Obsessive-Compulsive Spectrum Disorders
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Critical success factors for safety management on road construction projects in Ghana: - A case study of Sefwi Asanwineso – Akontommra – Boodi road

A thesis submitted to the Department of Construction Technology and Management College of Art and Built Environment in partial fulfillment of the requirements for the Degree of Master of Science. November, 2018

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
HUBUNGAN KEYAKINAN DIRI DAN AKTIVITAS PERAWATAN MANDIRI PASIEN HIPERTENSI DI WILAYAH KERJA PUSKESMAS PAHANDUT KOTA PALANGKA RAYA

Hypertension is one of the most common causes of morbidity and mortality in worldwide. Hypertension is also called a "silent killer" because people with hypertension often do not show symptoms. People who suffer from hypertension are usually unaware of his condition. The understanding of the patient and the ability of self care behavior of hypertensive patients is also very low. Non-compliance with this self care behavior can adversely affect the health of people with hypertension. The objective of this research is known the association of self efficacy and self care activity of hypertension patients in the working area of ​​Puskesmas Pahandut Palangka Raya City. Methods this research is used descriptive correlational research design with cross sectional study approach. Sampling technique in this research is using nonprobability sampling technique that is concecutive sampling with 50 respondents. Data collection was done for 2 months by measuring self efficacy level and self care activity using questionnaire. The statistical test used is Chi Square test. The results showed that most of the respondents had good efficacy level of 70%. Most of the respondents sufficient level of self care activity is 58. Pearson Chi Square correlation test results self efficacy and self care activities showed that there is a negative and insignificant relationship between self efficacy and self care activities of hypertensive patients. The conclusion of this research is there is no significant relationship between self efficacy with self care activity of hypertension patient. Further research with randomized controlled clinical trial design and a large number of samples should be undertaken to develop nursing interventions with behavioral approaches in order to improve self efficacy and self care behavior so as to reduce hypertension complications and improve the quality of life of hypertensive patients.;Keywords: self efficacy, self care activity, hypertension

Topic: Public Health and Nutrition
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
HOSTS AND CHAMPIONS: TAKING THE COMMONWEALTH GAMES SCOTLAND ARCHIVE ON TOUR

The University of Stirling holds the Commonwealth Games Scotland Archive, a large collection of material recording the story of Scotland’s participation in the Commonwealth Games. Hosts and Champions: Scotland in the Commonwealth Games is a touring exhibition celebrating over 80 years of participation and achievement by Scotland in the Commonwealth Games from its origin as the British Empire Games held in Hamilton, Canada in 1930, through to Glasgow 2014. Drawn from the Commonwealth Games Scotland Archive the exhibition displays a selection of photographs, designs, clothing, papers and artefacts which evoke a rich story of Scotland’s involvement in the Games, including as hosts in 1970, 1986 and 2014. This article traces the development of the touring exhibition, from the arrival of the Commonwealth Games Scotland Archive at the university, through an initial pop-up exhibition in Glasgow during the 2014 Games and on to the current touring programme supported by Legacy 2014.

Topic: Sport and Mega-Event Impacts
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences