jimnoneill/paper-to-field-training huggingface dataset:
A Model for Servant Leadership, Self-Efficacy and Mentorship

Mentoring plays an important role in the personal and professional development process. As such, it is critical to assess those aspects which may increase mentoring effectiveness. Using qualitative research and a review of the literature, we examine the purpose behind mentoring and the operation of servant leadership and some of its traits. In addition, we propose a model for servant leadership, self-efficacy and mentorship. The model suggests that the exercising of servant leadership traits may positively impact mentor and mentee self-efficacy. This, in turn, may improve the effectiveness of the mentoring relationship, facilitate the transformation process in both the mentor and mentee, and result in the personal and professional development of the mentor and in particular, the mentee.

Topic: Mentoring and Academic Development
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Abstract 4320: A novel digitally directed tissue microdissection platform integrates digital pathology with molecular analysis: Case study in metastatic colorectal cancer

Abstract Artificial intelligence (AI) based digital pathology has been getting rapid adoption over the last 2 to 3 years These AI based digital pathology models can analyze samples at high resolution and scale Retaining that resolution at scale through molecular analysis is key to the discovery of novel biomarkers We have developed a technology that can integrate AI-supported digital pathology (DP) algorithms to identify informative tissue regions for selective microdissection to improve molecular analysis of FFPE material The system is capable of extracting DNA, RNA or proteins with cellular (10 micron) resolution from FFPE tissue sections. The samples are ready for use in off-the-shelf molecular analysis workflows (qPCR, Next Gen Sequencing, etc) The system decreases the tumor cellularity requirements for clinical analysis by extracting only the area enriched for informative biomarkers To demonstrate the capability of the system we used an AI based digital pathology model that was developed to identify multiple cellular phenotypes from a H&amp;E stained colorectal cancer FFPE tissue sections We used the digital pathology output to guide the microdissection of RNA from tumor buds, carcinoma, immature stroma and inflammatory stroma in a paired designed RNA seq experiment The data showed that the system is capable of enriching the tumor-bud tissue content from&amp;lt;1% in the tissue to ~50% purity in the crude lysate Bioinformatic analysis of the RNAseq signatures showed that the tumor buds had a distinct RNAseq signature relative to the other three cell types and that the gene expression pattern was consistent with EMT pathways. The methodology is scalable, robust, and simpler than current microdissection techniques. This technology can be used to develop novel tests by integrating with AI algorithms, targeting tissue enriched for predictive biomarkers, and enabling low tumor cellularity samples to be analyzed with high precision. Citation Format: John H. Butler, Bidhan Chaudhuri, Katie Konigsfeld, Rish Pai. A novel digitally directed tissue microdissection platform integrates digital pathology with molecular analysis: Case study in metastatic colorectal cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4320.

Topic: Molecular Biology Techniques and Applications
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Mackenzie Inuit Whale Bone Industry: Raw Material, Tool Manufacture, Scheduling, and Trade

The bones of bowhead whales (Balaena mysticetus) were used by Mackenzie Inuit groups in producing a number of items essential to transportation and procurement. However, the whale bone industry, and its relationship to Mackenzie Inuit economic and social systems, is poorly understood. A recently excavated archaeological assemblage from McKinley Bay, Northwest Territories, provides a record of intensive Nuvugarmiut whale bone tool manufacture, which can be used to reconstruct a reduction sequence. Bowhead bone reduction at McKinley Bay focused on ribs, which were transversely worked into large sections. Cortical blanks were isolated from central rib sections, but proximal and distal rib sections were treated directly as blanks and preforms for the production of large durable tools, such as harpoon heads, adze sockets, mattock blades, and picks. The intensive whale bone reduction at McKinley Bay was part of a broader gearing-up strategy focused on the manufacture and repair of sleds and harpoons needed for the late winter migration and spring seal hunt. More generally, because the whale bone industry was intimately related to the bowhead hunt and its proceeds, it may provide fundamental insights about key aspects of coastal whaling societies, such as social organization, redistribution, and inter-territorial trade.

Topic: Indigenous Studies and Ecology
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Bad Girls Go Everywhere, but not Together: Gender Homophily and Co-mobility after Organizational Failure

Employees’ mobility affects positively individual and firm outcomes. Mirroring these findings, co-mobility research, analyzing group transitions, finds positive links between the comobility<br/>and performance. Latest population study of co-mobility found that 10-11% of all transitions involve more than one individual. Although co-mobility is an important phenomenon, its antecedents are still unknown. This study addresses this gap in the co-mobility literature by studying the effects of various dimensions of homophily between co-mobile employees as antecedents of co-mobility. Our research context is a natural experiment of an exogenous and unexpected organizational collapse. By analyzing 34.040 moves, we find support for our claims on positive effects of national homophily on co-mobility. We also find strong evidence that genderbased homophily affects co-mobility differently for men and women. For men, a genderhomophilic dyad has a higher likelihood of co-mobility. Such trend is negative for women. We provide some evidence that while dyads composed of males are less at risk of demotion and more likely to be promoted in their new employment, female dyads are vulnerable and more prone to demotion. These include female dyads containing a senior manager. We contribute to the co-mobility literature and extend the literature on the effects of<br/>homophily on ties.

Topic: Work-Family Balance Challenges
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
An Examination of the Motivations of Sporting Event Volunteers at Clemson University

In 2006, The Corporation for National and Community Service partnered with the Bureau of Labor Statistics to add a volunteer section to the Current Population Survey (CPS) that is sent out to 60,000 households each year. That year it was reported that 61.2 million people volunteered their time, effort, and labor through or for an organization. An additional 5.3 million people did volunteer work informally through helping their communities. Organizations across the world, specifically sports organizations, rely heavily on volunteers for success. Volunteers at the 2004 Summer Olympics (45,000), based off the assumption of working a full 8 hour for 16 days and the federal minimum wage before 2007 of $5.15, saved the Olympics an estimated $29,664,000 in American currency. The challenging issue for these organizations is maintaining volunteers year after year. \t\t\t At Clemson University, the athletic department has a volunteer group that assists with running Olympic sports. Known as CAVA (Clemson Athletic Volunteer Ambassadors), this group is responsible for ushering, greeting, and ticket taking. As compensation for their assistance, the athletic department gives CAVA members a free meal voucher at the event they work, official Clemson merchandise, and invites them to recognition banquets throughout the year. Ensuring that these volunteers continue to work with the program is important to the fiscal health of the overall athletic department. \t\t\t The Sport Volunteer Survey (SVS), which focuses on five factors of volunteerism, was distributed to CAVA members. Two of the five factors reported overall mean scores above 3.0 of a 5 point scale of importance. Those factors were the purposive and external factors. The three factors with scores lower than 3.0 were the egoistic, leisure, and material factors. An independent t-test identified the mean score of one factor, leisure, to be significantly different by gender.

Topic: Nonprofit Sector and Volunteering
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Shortness of breath in a 27-year-old man

department editor Matt Goldstein is director of the Health and Wellness Center, Health Enhancement and Cardiovascular Services, Good Samaritan Hospital, Baltimore, Maryland, and teaches in the Doctor of Health Science Program at Nova Southeastern University. He has indicated no relationships to disclose relating to the content of this article.

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Evaluative Analysis of Citrulline Supplementation Among Athletic Populations

The fundamental purpose of this article is to chronicle the endogenous mechanisms which drive the conversion of citrulline into nitric oxide and examinethe efficacy and applicability of citrulline supplementation among healthy and compromised populations. Citrulline, anantecedent of the conditionally essential amino acidarginine, has grown increasingly popular among athletic populations and bodybuildersin recent years for its ostensiblepossession of ergogenic andanabolic capacities. The purported benefits of citrulline supplementation and associated clinical applications will beintroduced and subsequently examined through an unbiased review of existing scientific literature.

Topic: Muscle metabolism and nutrition
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study)

OBJECTIVE The expression of vascular endothelial growth factor (VEGF) is elevated in diabetic macular edema (DME). Ranibizumab binds to and inhibits multiple VEGF variants. We investigated the safety and efficacy of ranibizumab in DME involving the foveal center. RESEARCH DESIGN AND METHODS This was a 12-month, multicenter, sham-controlled, double-masked study with eyes (age &amp;gt;18 years, type 1 or 2 diabetes, central retinal thickness [CRT] ≥300 μm, and best corrected visual acuity [BCVA] of 73–39 ETDRS letters [Early Treatment Diabetic Retinopathy Study]) randomly assigned to intravitreal ranibizumab (0.3 or 0.5 mg; n = 51 each) or sham (n = 49). The treatment schedule comprised three monthly injections, after which treatment could be stopped/reinitiated with an opportunity for rescue laser photocoagulation (protocol-defined criteria). After month 1, dose-doubling was permitted (protocol-defined criteria, injection volume increased from 0.05 to 0.1 ml and remained at 0.1 ml thereafter). Efficacy (BCVA and CRT) and safety were compared between pooled ranibizumab and sham arms using the full analysis set (n = 151, patients receiving ≥1 injection). RESULTS At month 12, mean ± SD BCVA improved from baseline by 10.3 ± 9.1 letters with ranibizumab and declined by 1.4 ± 14.2 letters with sham (P &amp;lt; 0.0001). Mean CRT reduction was 194.2 ± 135.1 μm with ranibizumab and 48.4 ± 153.4 μm with sham (P &amp;lt; 0.0001). Gain of ≥10 letters BCVA from baseline occurred in 60.8% of ranibizumab and 18.4% of sham eyes (P &amp;lt; 0.0001). Safety data were consistent with previous studies of intravitreal ranibizumab. CONCLUSIONS Ranibizumab is effective in improving BCVA and is well tolerated in DME. Future clinical trials are required to confirm its long-term efficacy and safety.

Topic: Retinal Diseases and Treatments
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
The Design and Use of Oligonucleotides

Chemically synthesized oligonucleotides are powerful tools in the molecular biologist's repertoire. This chapter describes the design of oligonucleotides and their applications, with particular reference to their use in the isolation and characterization of recombinant DNA clones. Examples of their use are taken either from the literature or from work carried out in our laboratory. Two specific areas are covered: the design of oligonucleotides, based on peptide sequence derived from a purified protein, for use in the isolation of clones from recombinant DNA libraries, and the design of consensus oligonucleotide probes, corresponding to conserved sequences in multigene families, for use in the isolation and characterization of such related genes. We do not cover the use of oligonucleotides for the localization of mRNA transcripts by in situ hybridization or for the analysis of mRNA steady-state levels by Northern blot analysis since this has been described elsewhere (,). A detailed discussion of all of the factors involved in the formation and melting of oligonucleotide/target DNA duplexes is beyond the scope of this treatise; for this, readers are referred to the work of Lathe (). However, formulae for the calculation of melting temperatures and the application of the base analog inosine are described in the Notes.

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Incorporating Fiction and Fantasy Into Family Therapy

Incorporating fiction and fantasy into a client's clinical reality is a helpful tool in accomplishing the task of rewriting problematic stories. Several methods for incorporating existing fiction are available, including the employment of client-identified characters, plots, role models, or inspirational figures. Such characters can be used to represent the client and members of his or her family in their shared systemic struggles and successes. Client-generated fiction and fantasy writing can also be useful in deconstructing and reconstructing meaning. The literature with regard to the incorporation of fiction and fantasy into therapy, cultural considerations, and examples of clinical composites are presented.

Topic: Counseling, Therapy, and Family Dynamics
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
PUS7‐dependent pseudouridylation of <i>ALKBH3</i> mRNA inhibits gastric cancer progression

Abstract Background RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions. Despite its significance, the role of mRNA pseudouridylation in cancer remains poorly understood. This study investigates the impact of pseudouridine synthase 7 (PUS7)‐mediated pseudouridylation of Alpha‐ketoglutarate‐dependent Dioxygenase alkB Homolog 3 ( ALKBH3 ) mRNA in gastric cancer. Methods Immunohistochemistry and Western blotting were used to assess PUS7 protein levels in human gastric cancer tissues. The relationship between PUS7 and gastric cancer progression was examined using 3D colony formation assays and subcutaneous xenograft models. Real‐time quantitative PCR (RT‐qPCR), Western blotting, and polysome profiling assays were conducted to investigate how PUS7 regulates ALKBH3. A locus‐specific pseudouridine (Ψ) detection assay was used to identify Ψ sites on ALKBH3 mRNA. Results Our findings indicate a significant reduction of PUS7 in gastric cancer tissues compared to adjacent non‐tumour tissues. Functional analyses reveal that PUS7 inhibits gastric cancer cell proliferation and tumour growth via its catalytic activity. Additionally, PUS7 enhances the translation efficiency of ALKBH3 mRNA by modifying the U696 site with pseudouridine, thereby attenuating tumour growth. Importantly, ALKBH3 functions as a tumour suppressor in gastric cancer, with its expression closely correlated with PUS7 levels in tumour tissues. Conclusions PUS7‐dependent pseudouridylation of ALKBH3 mRNA enhances its translation, thereby suppressing gastric cancer progression. These findings highlight the potential significance of mRNA pseudouridylation in cancer biology and suggest a therapeutic target for gastric cancer. Highlights PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis. The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Kolaborasi Pemerintah Dan Pelaku Usaha Sulawesi Tengah Untuk Mengembangkan Komoditas Rumput Laut

Central Sulawesi, one of the largest seaweed-producing provinces in Indonesia after South Sulawesi, but only uses seven per cent of its potential cultivation land. Despite its large production, the quality of Central Sulawesi seaweed is low due to a lack of coordination between the government and seaweed entrepreneurs, both in cultivation, post-harvest management, distribution, and marketing. To overcome this problem, development efforts are needed through the cooperation of local governments and business actors. This qualitative research aims to analyse the development of seaweed production quality and yield in Central Sulawesi with a focus on such cooperation. Recommended measures include improving production quality in Morowali and Banggai Laut districts, providing storage and transport, establishing processing industries, and zoning cultivation.

Topic: Fisheries and Aquaculture Studies
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Diskursus Gerakan Salamullah Lia Eden

Indonesia has been overcrowded by spiritual movements which provide a quest for spiritual satisfaction. Among all spiritual movement in Indonesia, Salamullah was a few leads by a woman. Lia Eden, her original name is Lia Aminuddin, took a significant role in the new spiritual movement in Indonesia. Interestingly, in patriarchal culture as in Indonesia, Lia Eden has successfully gained followers from both sexes. The question then arises, what kind of pedagogical method she used to gain followers? How Salamullah treat followers from different sexes? Are there any differences? This paper is aim to answer those questions based on spirituality, pedagogy, and Salamullah as a counter-public movement. The narration of Salamullah movement will be started from its history which then continued by the pedagogical approach used by Salamullah, and the next narration will examine the position of Salamullah as a counter-public movement.&#x0D; [Telah sejak lama gerakan spiritual meramaikan kontestasi agama di Negara Indonesia. masifnya gerakan spiritual di Indonesia tidak terlepas dari upaya untuk memenuhi kepuasan secara spiritual. Menariknya, dari sekian banyak gerakan spiritual yang berkembang di Indonesia, terdapat Salamullah yang dipimpin oleh seorang perempuan. Lia Aminuddin, atau yang lebih dikenal dengan Lia Eden memiliki peran yang sangat signifikan dalam gerakan spiritual di Indonesia sebagai salah satu pendobrak sistem keagamaan yang telah lama dikuasai oleh kekuasaan patriarki. Terlebih lagi, Lia Eden dapat menarik pengikut dari kedua gender, laki-laki maupun perempuan. Pertanyaan yang muncul kemudian adalah narasi apa yang ia gunakan untuk menarik para pengikut? Bagaimana Salamullah memperlakukan pengikut dari gender yang berbeda? Apakah mereka diperlakukan dengan sama? Makalah ini mencoba menjawabnya melalui tema spiritualitas, narasi, dan gerakan Salamullah sebagai suatu counter-public. Penjelasan akan diawali dengan sejarah singkat Salamullah yang dilanjutkan dengan penjabaran narasi yang digunakan oleh Lia Eden, serta diakhiri dengan analisis gerakan Salamullah sebagai suatu counter-public.]

Topic: Islamic Studies and Radicalism
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Characterization of Lactose Esters for Their Antimicrobial and Emulsification Properties

Sucrose esters have an established use in food industry as emulsifiers. Two novel lactose esters (lactose monodecanoate and lactose monomyristate) were synthesized and studied for their antimicrobial and emulsification properties. Lactose is a byproduct in cheese production and is an inexpensive carbohydrate source. The antimicrobial activity of lactose monodecanoate (LMD) and lactose monomyristate (LMM) was tested against the growth of seven different bacteria. Both esters, when dissolved in dimethoxy sulfoxide (DMSO), proved bactericidal against Bacillus cereus, Mycobacteria KMS and Streptococcus suis. LMM/DMSO was bactericidal against B. cereus at concentrations between 1 and 3 mg/ml. LMM/DMSO was bactericidal against M. KMS and S. suis at concentrations between 3 and 5 mg/ml. LMD/DMSO was bactericidal against B. cereus and S. suis at concentrations between 1 and 3 mg/ml and against M. KMS at concentrations between 0.1 and 1 mg/ml. LMM/DMSO and LMD/DMSO were not effective in inhibiting the growth of Listeria monocyotgenes and Enterococcus faecalis. The antimicrobial effects of LMD on the growth of Listeria monocytogenes and Enterococcus faecalis were found to be solvent dependent. LMD, when dissolved in 30% ethanol, was able to inhibit the growth of L. monocytogenes at concentration between 1 and 3 mg/ml and E. faecalis at concentration between 3 and 5 mg/ml. The growth of Streptococcus mutans and Escherichia coli O157:H7 remained unaltered in the presence of LMD/ETOH, LMD/DMSO and LMM/DMSO up to 5 mg/ml. LMM was also analyzed for its emulsification properties. The destabilization rates and droplet size of the emulsion were determined for five consecutive days. At a concentration of 0.5%, LMM produced 20% oil in water emulsion with destabilization rate of 1.1 mm/day, which can be considered a stable emulsion. The droplet size of the emulsion was also within the range of 0-10 μm. Lower droplet size range signifies the effective work of the LMM as an emulsifier. Also the droplet size of the emulsion was found to be consistent over five days, which is indicative of a stable emulsion.

Topic: Probiotics and Fermented Foods
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Role of annealing time on junction depth for high dose phosphorus implants

Twenty-two wafers were implanted with 5/spl times/10/sup 15/ P cm/sup -2/ at 50 keV, one set of 11 with a beam current of 5.0 mA. The remaining 11 with a beam current of 0.5 mA. Wafers of each set were annealed at 800/spl deg/C for 1, 2, 4, 8, 16, 30, 60, 120, and 240 secs. All wafers were evaluated by secondary ion mass spectrometry, transmission electron microscopy, sheet resistivity, thermal wave analysis and tapered groove profilometry. Transient enhanced diffusion was completed during the first 4 to 8 seconds. Loop dislocations were detected after 1 second of anneal, suggesting that transient enhanced diffusion was restricted by the absorption of the free interstitials by the growing loop dislocations.

Topic: Integrated Circuits and Semiconductor Failure Analysis
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences