jimnoneill/paper-to-field-training huggingface dataset:
Family-friendly : homo-affinity in the French sentimental novel, 1770-1850

This dissertation investigates the central significance of desire for the self defined as different-than-the-self––of an affect I articulate as homo-affinity––within the domains of Romanticism, Romantic love, and the French Sentimental novel. As expressed in my Introduction, this project is predicated on an analysis of the erotics of sameness, the literary trace of outlaw desire, and the exploration of a queer archive of feelings in the French Sentimental novel. Chapter One pertains to François-René de Chateaubriand’s Atala/René (1801), in which I outline the Romantic topos that serves as a forerunner to the ideal of homo-affinity in the French Sentimental novel. In keeping with Chateaubriand’s autobiographical mode of fiction, the enchanteur’s reliance on reflexive metaphors yields a chiasmatic mirror through which his protagonists might envision another version of themselves and that, as such, conditions the experience of an expansive desire that encompasses passions toward incest, homosexuality, and narcissism––if not a newfound libertinage. In Chapter Two, I examine archival documents that obtain to the manuscripts of Claire de Duras’s Olivier, ou le secret (1821-1824) in order to expose the author’s careful treatment of the closet, which revolves around her creation of a linguistic polari that could furtively portray the eponymous secret and its relevance among writers and intellectuals of Restoration France. Finally––in Chapter Three––I go on to posit that Stendhal, in Armance (1828), deliberately reinscribes and multiplies the erotically charged bonds that figure between knights in pre-Revolutionary novels and chivalric lore, so as to forge a trope for the expression of homosexuality––and even that of a homosexual subject––within his satire of Romanticism. Throughout these chapters, I illustrate how the interconnectivity of these topoi (such as the chiasmatic mirror, parlor polari, and Romantic chevalerie) constitutes a coherent expression of homo-affinity that spans the formation of the French Sentimental novel. In the end, I conclude that the prevalence of a (now queer) attraction toward sameness in Sentimentalism and Romanticism intertextually colored a handful of subsequent literary movements and, ultimately, determined the emergence of homo-affinitive (and equally non-heterosexual) narratives across the evolution of the French novel in the nineteenth and twentieth centuries.

Topic: Historical and Literary Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Diagnostic decision support tool for anemias based on label-free holographic imaging

We propose a new diagnostic tool for anemias identification based on quantitative phase imaging. We introduce a panel of label-free optical markers to identify red blood cell (RBC) phenotypes, demonstrating that an optical fingerprint of RBC is related to erythrocyte disease through modeling RBC as biological lens.

Topic: Erythrocyte Function and Pathophysiology
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
A novel self-assembled lipid-polymer hybrid system for efficient yet biocompatible gene delivery

Lipid-polymer hybrid systems are gaining ever-increasing interest for the treatment of diseases arising from genetic mutations due to their facile synthetic protocols, being readily scalable, of low cytotoxicity, and crucially effecting gene transfer in a synergistic fashion. In the present study, a self-assembled hybrid gene delivery platform (EGCDNPs) comprised of a chitosan derivative EAGC [Ν-(2-ethylamino)-6- Ο-glycolchitosan] and a ‘helper lipid’ of DOPE (1,2-dioleoyl-sn-glycero-3- phosphoethanolamine) was prepared. This hybrid system is highly amenable to finetuning its molecular variables, such as molecular weight and ethylamino mole substitution, in order to achieve distinct in vitro and in vivo gene transfer properties. In total, three distinct gene delivery carriers were produced: E17GC43DNPs, E25GC45DNPs, and E28GC83DNPs. Regarding the influence of the ethylamino mole substitution of EAGC on the gene transfer behaviour of EGCDNPs, E25GC45DNPs (the higher level of ethylamino groups) achieved high gene transfection efficiency in in vitro cell lines, whereas E17GC43DNPs (the lower level of ethylamino groups) showed a very poor transfection performance. Concerning the molecular weight influence of EAGC on the gene transport performance of EGCDNPs, E28GC83DNPs (higher molecular weight) were more efficient with respect to firefly luciferase plasmid delivery to the healthy murine bladder in vivo as compared to E25GC45DNPs (lower molecular weight). Moreover, E28GC83DNPs could adhere to the murine bladder urothelium and even penetrate deeper into the regions of bladder lamina propria.

Topic: RNA Interference and Gene Delivery
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Rehearsals of Teaching and Opportunities to Learn Mathematical Knowledge for Teaching

This study addresses how rehearsals of teaching could support teachers in developing mathematical knowledge for teaching (MKT). The analysis of 30 rehearsals, from elementary methods courses in 3 teacher education programs, attends to what novice teachers and teacher educators did in rehearsal that enlisted MKT. The findings elaborate the tasks that enlisted MKT in practice and the work of the teacher educator in supporting novice teachers' learning of MKT inside the interactive work of teaching.

Topic: Mathematics Education and Teaching Techniques
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Usability matters for virtual reality simulations teaching communication

The human papillomavirus (HPV) vaccine is effective at reducing HPV-associated cancers; however, current vaccination rates in the United States are estimated at only 60%.Clinicians can positively impact caregivers' decisions to vaccinate through the use of evidence-based communication strategies.Nevertheless, current continuing medical education (CME) related to HPV vaccination primarily consists of online didactic-based trainings with limited opportunities to practice skills.Immersive virtual reality (VR) that uses a 3D-mounted headset may promote skill development by allowing deliberate practice of communication strategies in a virtual clinic environment.Immersive VR has not been previously applied to CME on HPV vaccination.Thus, we conducted usability testing of four VR simulations focused on HPV communication strategies at an urban adolescent primary care clinic.Usability testing, a critical but underutilised method, focuses on assessing how an intervention serves its intended purpose by utilising expert users to identify gaps and weaknesses. 1 | WHAT WAS TRIED?During the 20-minute VR curriculum, participants verbally counselled animated caregivers (avatars) hesitant to accept the HPV vaccine for their children.The avatar's responses to the participant's counselling were driven in real time by a facilitator (FR).For the participant to succeed (vaccine accepted), he or she had to demonstrate evidence-based communication

Topic: Mobile Health and mHealth Applications
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Metastasizing Pleomorphic Adenoma of the Salivary Gland Involving the Sternum: A Case Report

Abstract: BACKGROUND: The acinar-ductal units of the three pairs of main salivary glands (submandibular, sublingual, and parotid) and small salivary glands are encircled by myoepithelial cells, which are functionally altered epithelial cells that produce extracellular matrix. The majority of salivary gland tumors are benign; large glands account for 70% of cases, while small glands account for 25%. Salivary gland tumors make up 2 to 6.5% of all head and neck neoplasms. Tumors in the salivary glands can be cancerous at different rates—most often in the sublingual gland, less so in the submandibular gland, and least commonly in the parotid gland. Among adults, pleomorphic adenoma is the most commonly diagnosed salivary gland tumor, which is often a benign with a well-defined circumference and a modest growth rate. Despite being malignant, metastatic pleomorphic adenoma (MPA) shares identical histological features with benign pleomorphic adenoma (PA). This report details a case of pleomorphic adenoma of the salivary gland exhibiting metastasis to the sternum in an geriatric patient.

Topic: Salivary Gland Tumors Diagnosis and Treatment
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Use of Ultraviolet C (UVC) Radiation to Inactivate Infectious Hematopoietic Necrosis Virus (IHNV) and Viral Hemorrhagic Septicemia Virus (VHSV) in Fish Processing Plant Effluent

\n\t\t\t\t\tWe determined the stability of infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) suspended in either fish processing plant effluent blood water (EBW) or culture media and examined the effectiveness of UVC radiation to inactivate IHNV and VHSV suspended in both solutions. Without exposure to UVC, IHNV and VHSV were maintained in 4&amp;deg;C blood water for up to 48 hours without significant reduction in virus titer. However when exposed to UVC radiation using a low pressure mercury vapour lamp collimated beam, IHNV and VHSV were inactivated, and the efficacy of UVC radiation was dependent upon the solution and virus type being treated. A 3-log reduction for VHSV and IHNV in culture media was achieved at 3.28 and 3.84 mJ cm-2, respectively. The UV dose needed for a 3-log reduction of VHSV in EBW was 3.82 mJ cm-2. However, exposure of IHNV in EBW to the maximum UVC dose tested (4.0 mJ cm-2) only led to a 2.26-log-reduction. Factors such as particle size, and possible association of viruses with suspended EBW particulate, were not investigated in this study, but may have contributed to the difference in UVC effectiveness. Future work should emphasize improved filtration methods prior to UV treatment of processing plant EBW at an industrial scale.&lt;br /&gt;\n\t\t\t\t

Topic: Aquaculture disease management and microbiota
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Reliability and validity of the Danish version of the Calgary Depression Scale for Schizophrenia

Depressive symptoms within the range of schizophrenic syndromes constitute a major diagnostic and therapeutic problem. Earlier research has indicated that available depression scales are not adequate when examining mood disturbances in patients with schizophrenia. We have made an attempt to estimate the reliability and validity of the Danish version of the Calgary Depression Scale for Schizophrenia. The external validity has been analysed in relation to the Major Depression Inventory (MDI). The internal validity has been analysed by using Loevinger's coefficient of homogeneity as the primary statistic. For the inter-observer reliability the intra-class coefficients have been calculated. It was shown that a subscale of the Calgary scale has sufficient reliability and validity.

Topic: Mental Health Research Topics
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Dynamic Tools for Outsourcing IT Firms in the Context of Innovation

To carry out this study, both the qualitative and quantitative methodologies have been used to collect the evidences and analyzed in light of comments, discussions and feedbacks recorded during surveys and interviews. Results of this case-study indicates, that the factors like positive attitude for innovation, investment towards R&D and willingness to adopt profit and risk sharing approach for business found prominent. However, lack of concern regarding IPRs and scientific publications has also been found in the firms. Statistics also reveal the absence of linear relationship among different variables however, association between some of the factors (i.e. IT outsourcing for innovation, Innovation is important for progress & survival and Investment in Research and Development) found significant. Keywords: Information Technology, Business Process Outsourcing, Information Technology Outsourcing, Human Resource Development, Innovation

Topic: Outsourcing and Supply Chain Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Primary Cardiac Valve Tumors

To assess the prevalence, characteristics, and outcome of surgical treatment of primary cardiac valve tumors in a single center, we reviewed our experience in 6 women and 1 man, aged 49 to 76 years (mean, 64.7 years) who presented between 1999 and 2006. In one patient, the diagnosis of cardiac valve tumor was made incidentally on transesophageal echocardiography during aortocoronary bypass surgery. The others had clinical symptoms: angina or myocardial infarction in 3, congestive heart failure in 2, dyspnea and cerebrovascular ischemia in 1 patient each. Four of the 7 tumors were benign, and 3 were malignant. All patients survived the operation and recovered uneventfully. Midterm follow-up was available in all patients. Two patients with malignant tumors were considered unsuitable for adjuvant therapy by the oncologist; both died during follow-up from local tumor recurrence. All 5 survivors were categorized at the last follow-up as functional class I, with normal exercise tolerance. Excellent early and midterm surgical results can be obtained in patients with benign cardiac valve tumors, but the prognosis for those with a malignant tumor is poor.

Topic: Cardiac tumors and thrombi
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Comparison of the SUMO1 and ubiquitin conjugation pathways during the inhibition of proteasome activity with evidence of SUMO1 recycling

To investigate potential interplay between the SUMO1 (small ubiquitin-related modifier-1) and ubiquitin pathways of post-translational protein modification, we examined aspects of their localization and conjugation status during proteasome inhibition. Our results indicate that these pathways converge upon the discrete sub-nuclear domains known as PML (promyelocytic leukaemia protein) NBs (nuclear bodies). Proteasome inhibition generated an increased number of PML bodies, without any obvious increase in size. Using a cell line that constitutively expresses an epitope-tagged version of SUMO1, which was incorporated into high-molecular-mass conjugates, we observed SUMO1 accumulating in clusters around a subset of the NBs. Nuclear ubiquitin was initially observed in numerous speckles and foci, which bore no relationship to PML NBs in the absence of proteasome inhibition. However, during proteasome inhibition, total ubiquitin-conjugated species increased in the cell, as judged by Western blotting. Concomitantly the number of nuclear ubiquitin clusters decreased, and were almost quantitatively associated with the PML NBs, co-localizing with the SUMO-conjugated pool. Proteasome inhibition depleted the pool of free SUMO1 in the cell. Reversal of proteasome inhibition in the presence or absence of protein synthesis demonstrated that free SUMO1 was regenerated from the conjugated pool. The results indicate that a significant fraction of the free SUMO1 pool could be accounted for by recycling from the conjugated pool and indeed it may be that, as for ubiquitin, SUMO1 needs to be removed from conjugated species prior to processing by the proteasome. Taken together with other recent reports on the proteasome and PML NBs, these results suggest that the PML NBs may play an important role in integrating these pathways.

Topic: Ubiquitin and proteasome pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
QEML (Quantum Enhanced Machine Learning): Using Quantum Computing to Enhance ML Classifiers and Feature Spaces

Machine learning and quantum computing are two technologies that are causing a paradigm shift in the performance and behavior of certain algorithms, achieving previously unattainable results. Machine learning (kernel classification) has become ubiquitous as the forefront method for pattern recognition and has been shown to have numerous societal applications. While not yet fault-tolerant, Quantum computing is an entirely new method of computation due to its exploitation of quantum phenomena such as superposition and entanglement. While current machine learning classifiers like the Support Vector Machine are seeing gradual improvements in performance, there are still severe limitations on the efficiency and scalability of such algorithms due to a limited feature space which makes the kernel functions computationally expensive to estimate. By integrating quantum circuits into traditional ML, we may solve this problem through the use of quantum feature space, a technique that improves existing Machine Learning algorithms through the use of parallelization and the reduction of the storage space from exponential to linear. This research expands on this concept of the Hilbert space and applies it for classical machine learning by implementing the quantum-enhanced version of the K nearest neighbors algorithm. This paper first understands the mathematical intuition for the implementation of quantum feature space and successfully simulates quantum properties and algorithms like Fidelity and Grover's Algorithm via the Qiskit python library and the IBM Quantum Experience platform. The primary experiment of this research is to build a noisy variational quantum circuit KNN (QKNN) which mimics the classification methods of a traditional KNN classifier. The QKNN utilizes the distance metric of Hamming Distance and is able to outperform the existing KNN on a 10-dimensional Breast Cancer dataset.

Topic: Quantum Computing Algorithms and Architecture
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Barriers and facilitators for community pharmacists’ participation in pharmacy practice research: a survey

Abstract Objectives The aim of this study was to explore pharmacists’ barriers and facilitators regarding participation in pharmacy practice research. Methods We conducted an online cross-sectional survey in 1974 community pharmacies in the Netherlands. Key findings A total of 252 pharmacists completed the questionnaire. The majority agreed that participation in research should be part of daily practice. Efficient time investment and a clear benefit for general professional knowledge, patient care and pharmacy organisation were the most important facilitating factors. Conclusions To encourage pharmacists’ participation, researchers should offer clear instructions, possibilities for flexible time management, simple patient inclusion, task delegation and no additional contacts with healthcare professionals due to the research.

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
P08.15: The role of uterine artery pulsatility index for prediction of outcome in pregnancies complicated by pre‐eclampsia

Objectives: To assess the correlation between mean artery pulsatility index (UtA PI), measured at diagnosis of pre-eclampsia (PE), gestational age (GA) at delivery, and birth weight (BW) percentile. To assess the predictive value of mean UtA PI for the development of adverse pregnancy outcome (APO).\nMethods: Cohort study on 100 consecutive singleton pregnancies complicated with PE referred to our Department (2010–2011). Mean UtA PI values obtained at the time of diagnosis of PE were analysed. Clinical and perinatal outcomes were reviewed. APO was defined as one of the following: Apgar score &lt; 7 at five minutes; pH &lt; 7.20; birth weight &lt; 5th percentile (SGA), stillbirth or neonatal death. Receiver-operating characteristics (ROC) curve calculated to determine the predictive ability for subsequent development of APO. Results: Median maternal age was 32 years (IQR 27–37 yrs), maternal BMI 21.9 kg/mq (IQR19.9–26.6 kg/mq), GA at diagnosis was 31 w (IQR 29+3–32+1), GA at delivery was 34+1 w (IQR 32+2–36+2 w), BW was 1629 g (IQR 1380–2050), BW percentile was 2.6th (0.5th – 8.9th ), pH was 7.27 (IQR 7.23 – 7.29). Fifty-six pregnancies developed APO. One case of stillbirth and four cases of neonatal death were observed. SGA occurred in 56/100 neonates. Mean ± SD UtA PI at diagnosis of PE was 1.40 ± 0.28 in women that developed APO and 1.10 ± 0.41 in women that did not develop APO (P = 0.02). There was a significant negative correlation between mean UtA PI and GA at delivery (r = −0.533, P = 0.002), and between mean UtA PI and BW percentile (r = −0.466, P = 0.007). The prediction of the subsequent development of APO, expressed as the area under ROC curve, was 61.6 (95% CI 0.44–0.79) for UtA PI at diagnosis of PE.\nConclusions: Our data confirm that mean UtA PI, assessed at diagnosis of PE, represent a good independent predictor for GA at delivery and BW percentile. However the predictive value for the subsequent development of APO does not seem to be clinically relevant.

Topic: Pregnancy and preeclampsia studies
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Obtaining and Characterizing the Industrially Important Thermostable α-Amylases from &lt;em&gt;B. amyloliquefaciens&lt;/em&gt; and &lt;em&gt;B. subtilis&lt;/em&gt;, Which Are Extracellularly Expressed by Bacillus Cells and Capable of Generating Different End Products after Starch Hydrolysis

The production of recombinant enzymes, mainly used for obtaining pure and functional target molecules, holds significant importance in modern biotechnology. This study aimed to produce recombinant α-amylases (Amy3500 and Amy1974), derived from B. amyloliquefaciens MDC1974 and B. subtilis MDC3500 respectively, using the pBE-S shuttle vector, and to characterize them. Both α-amylase genes were molecularly cloned into the E. coli/B. subtilis pBE-S shuttle vector, both with (Amy1974sig and Amy3500sig) and without their own signal peptides (Amy1974 and Amy3500), along with a signal peptide originating from the plasmid, and tested in flask fermentations. For recombinant Amy3500, the amylase variants resulted in similar levels of volumetric activity (700-750 U/mL). In contrast, the expression of Amy1974 nearly doubled compared to Amy1974sig with double signal peptides, reaching 2000 U/mL. The SDS-PAGE estimated the molecular weight of Amy1974 α-amylase to be 54.6 kDa, which was in accordance with the theoretical molecular mass calculations. However, the estimated molecular weight of Amy3500 amylase was significantly reduced when exiting the producer cells. Ca2+ had no significant activating effect on the activities of Amy1974 amylase and Amy3500 amylase, likely due to its tight binding to the protein scaffold. Both enzymes exhibited broad activity peaks between 45-70°C, with a maximum at 65°C. The Amy1974 and Amy3500 α-amylases demonstrated broad pH optima and pH-dependent thermostability, with optimum pH values at 6.5 and 5.8, and thermal stability peaks at pH 7.6 and 5.9, respectively. Both α-amylases displayed high relative activity against various starches, including corn amylopectin and potato amylose, while showing comparatively lower activity towards cyclodextrins. The Amy1974 amylase converts starch to dextrins of varying lengths, whereas Amy3500 almost entirely converts starch into glucose.

Topic: Enzyme Production and Characterization
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences