jimnoneill/paper-to-field-training huggingface dataset:
Structure investigation of amphiphilic cyclopeptides in isotropic and anisotropic environments—a model study simulating peptide–membrane interactions

It has been proposed that the membrane allows a much more efficient binding of certain small or medium-sized amphiphilic messenger molecules to their receptor, not only by accumulation of the drug, but also by induction of orientations and conformations that are much more favorable for receptor docking than structures adopted in isotropic phases. A series of eight amphiphilic cyclic peptides containing lipophilic (L-α-aminodecanoic acid=Ada, L-α-aminohexadecanoic acid=Ahd, Nhdg=N-hexadecylglycine) and hydrophilic (Lys, Asp) amino acids were synthesized and examined by means of NMR spectroscopy and molecular dynamics (MD) simulations in isotropic (CDCl3) and membrane-mimicking anisotropic (SDS/H2O) solvents to study the influence of the environment on their individual conformations. NMR data of cyclo(-Gly1-D-Asp2-Ahd3-Ahd4-Asp5-Gly6-) (C4), cyclo(-Lys1-D-Pro2-Lys3-Ada4-Pro5-Ada6-) (C5) and cyclo(-Lys1-Pro2-Lys3-Ada4-D-Pro5-Ada6-) (C6) clearly indicate that those compounds are too rigid to perform a conformational change upon transition from an isotropic to an anisotropic environment. On the other hand, the experimental data of cyclo(-Gly1-Asp2-Ahd3-Ahd4-Asp5-Gly6-) (C1), cyclo(-Asp1-Ala2-Nhdg3-Ala4-D-Asp5-) (C7), and cyclo(-D-Asp1-Ala2-Nhdg3-Ala4-Asp5-) (C8) suggest highly flexible unstructured molecules in both environments. However, for cyclo(-Asp1-Asp2-Gly3-Ahd4-Ahd5-Gly6-) (C2) we observed a structure inducing effect of a membrane-like environment. The compound populates three different conformations in SDS/H2O, whereas in CDCl3 no preferred conformation can be detected. cyclo(-D-Asp1-Asp2-Gly3-Ahd4-Ahd5-Gly6-) (C3) clearly exhibits two different conformations with a shifted β,β-turn motif in CDCl3 and SDS/H2O solutions. The conformational change could be reproduced in a restraint-free MD simulation using the biphasic membrane mimetic CCl4/H2O. Our results give clear evidence that membrane interactions may not only lead to structure inductions, but can also induce major conformational changes in compounds already exhibiting a defined structure in isotropic solution. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.

Topic: Chemical Synthesis and Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Corporate image, customer satisfaction and loyalty among customers in air conditioner industry: Basis for customer relationship management model

Based on the field of air conditioner industry, this study mainly determined the various dimensions of corporate image, customer satisfaction and customer loyalty of Chinese air conditioner enterprises, and defined the customer relationship management system driven by corporate image for Chinese air conditioning companies.Through empirical research, descriptive statistics and inferential analysis were carried out on the questionnaire data of 567 respondents from the survey by SPSS version 28, and the status quo of the evaluation of the dimensions of corporate image, customer satisfaction and customer loyalty of Chinese air conditioner companies was revealed, the relationships among corporate image, customer satisfaction and customer loyalty were obtained.Specifically, this study showed that respondents agreed on the evaluation indicators related to the corporate image, customer satisfaction and customer loyalty of the air conditioning enterprises involved, and the important role of natural image, service image, product image, corporate behavior and other factors in shaping corporate image.The study also revealed the importance of customer satisfaction and customer loyalty to enterprises to obtain market competitiveness.Meanwhile, through the correlations among corporate image, customer satisfaction and customer loyalty tested in this study, it was concluded that corporate image has a positive and significant relationship with customer satisfaction and customer loyalty, meaning the better corporate image is, the higher customer satisfaction and customer loyalty will be.The empirical research results also showed that there is a strong positive and significant correlation between customer satisfaction and customer loyalty, which means the higher the customer satisfaction, the higher the customer loyalty.This paper also created a customer relationship management model of Chinese air conditioner enterprises, indicating that a good customer relationship management model should be composed of corporate image, customer satisfaction and customer loyalty.Finally, based on this study, the researcher provided relevant suggestions which have certain empirical reference significance for air conditional industry.

Topic: Customer Service Quality and Loyalty
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Hematopoietic stem cell transplantation activity in Mexico during the COVID19 pandemic: on the way to recovery

To analyze the number of HSCTs performed in 2019 vs. 2020 and report the status of transplant centers (TCs) during and a year after the COVID-19 pandemic.We performed a comprehensive cross-sectional nationwide study including active TCs interrogating HSCT activity from 2019 through September 2021. An electronic survey was sent to TCs and consisted of items regarding the number and characteristics of procedures performed and were compared yearly. Changes to their institutions' transplant policies and practices during the COVID19 pandemic were also documented. Fifty centers were invited to participate, 33 responded.Most TCs were part of the public health system (63.7%). Almost half are in the country's capital, Mexico City (45.5%). Most centers performed <10 procedures per year. The number of HSCTs decreased from 835 in 2019-505 in 2020 (p < .001), representing a 40% reduction in transplant activity. The monthly transplant rate in 2021 increased to 58.3, compared to 42 in 2020 and close to 69.5 in 2019 (p < .001). All types of HSCTs decreased excluding haploidentical transplants. All institutions treated patients with COVID19, and over two-thirds experienced some form of hospital reconversion. Transplant activity stopped completely in 23 TCs (70%) during the pandemic with a median closure duration of 9.9 months (range, 1-21). In 2021, 9.1% of TCs remained closed, all of them in the public setting.The limited transplant activity in Mexico decreased significantly during the pandemic but is recovering and nearly in pre-pandemic levels.

Topic: Hematopoietic Stem Cell Transplantation
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Compositional Characterization of Glassy Volcanic Material From VNIR and MIR Spectra Using Partial Least Squares Regression Models

This is supporting data for the paper titled "Compositional Characterization of Glassy Volcanic Material From VNIR and MIR Spectra Using Partial Least Squares Regression Models" by Leight et al. (submitted to JGR-P 11/23). Table S1 lists each spectrum used to train PLS models, its source, and which training datasets the spectrum was included in. Zip files contain the MIR and VNIR PLS model files. Model files are .asc, and can be run using the code at Ytsma, (2022), https://doi.org/10.5281/zenodo.7347345.

Topic: Geochemistry and Geologic Mapping
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Thermo-oxidative stability of waterborne polyurethanes with catalysts of different selectivity evaluated by non-isothermal thermogravimetry

Thermogravimetry was used for the evaluation of the thermo-oxidative stability of waterborne polyurethanes (wbPUR) containing catalysts of different selectivity. From Arrhenius plots, activation energies of between 50 and 120 kJ mol-1 for wbPUR were determined, depending on the temperature interval, selectivity of the catalyst and degree of degradation. Waterborne polyurethanes without catalyst showed lower thermal stability than waterborne polyurethanes with catalysts of different selectivity. Non-isothermal thermogravimetry indicated the presence of different degradation processes and enabled the kinetics parameters at higher degrees of degradation to be evaluated. .

Topic: Polymer composites and self-healing
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Analysis of the Long Needs of Container Dock in the Port of Sorong, Indonesia

The limited facilities and infrastructure, as well as the natural geographical conditions that do not supportat the Port, will likely reduce the performance of the Port so thatthe services provided are not optimal. This study examines how to improve loading and unloading services, especially the need for container loading and unloading equipment needed to support container loading and unloading activities at this time and predictions for the next five years, besides also calculating how wide the stacking yard needed to accommodate the number of containers container coming in Sorong Port in the next five years. This type of research is quantitative with data analysis techniques that are linear regression and calculation of the length of the container dock. From the research results obtained (1) Fulfillment of loading and unloading equipment needs include: a) Quay container crane 1 unit (capacity 20-25 boxes/hour), b) Rubber tired 1 unit (capacity 18-23 boxes/hour), c) Head unit and chassis 4 units, d) Forklift 2 units (capacity of 4 tons and capacity of 2 tons); (2) Construction of a wharf specifically for containerships with a length of 226 meters; (3) Rearrangement of space utilization in the area of the stacking field and the process of flow in and out of containers

Topic: Maritime Ports and Logistics
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Development of acetabulum after closed reduction in developmental hip dysplasia.

The radiographic study of acetabulum development after closed reduction of 87 congenitally dislocated hips in 64 patients who were treated between 1980 and 1990 was conducted retrospectively. An average patient's age at the moment of closed hip reduction was 16 months (range between 6 to 24 months). On the average, patients were 16 months old (range between 6 to 24 months) at the moment of closed hip reduction. Development of bony acetabulum was followed for 8 years by measuring the AC angle. According to the age at the moment of closed reduction patients were sorted into three groups, the first group from 6 months to 12 months old (39 hips), the second group from 12 to 24 months old (28 hips) and the third group from 24 to 36 months old (20 hips). At the beginning of the treatment mean values of the AC angle in the first group were 37.2 degrees +/- 3.31 degrees; in the second group 39.7 degrees +/- 3.2 degrees; and in the third group 43.8 degrees +/- 2.7 degrees. The final values of the AC angle in the first group were 14.7 degrees +/- 3.21 degrees, in the second group 21 degrees +/- 3.02 degrees; and in the third group 24 degrees +/- 3.76 degrees. Normally and mildly dysplastic hips were achieved in 80.5% treated hips, while in 19.5% treated hips medium and serious dysplasia retarded. The acetabulum development in dysplastic hip after retained stable concentric reduction was the same as in the normal hip. The operative reconstruction of acetabulum should not be done before the third year of life.

Topic: Hip disorders and treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Impact of Distributed Energy Resources on Frequency Regulation of the Bulk Power System

The growing penetration of distributed energy resources (DERs) has increased the complexity of the power system due to their intermittent characteristics and lower inertial response, such as photovoltaic (PV) systems and wind turbines. This restructuring of the power system has a considerable effect on the transient response of the system resulting in inter-area oscillations, less synchronized coupling and power swings. Furthermore, the concept of being distributed itself and generating electricity from multiple locations in the power system makes the transient impact of DERs even worse by raising issues such as reverse power flows. This paper studies some impacts of the changing nature of power system which are limiting the large scale integration of DERs. In addition, a solution to increase the inertial response of the system is addressed by adding virtual inertia to the inverter based DERs in the power system. The proposed control results in increasing the stability margin and tracking the rated frequency of the system. The injected synchronized active power to the system will prevent the protection relays from tripping by improving the rate of change of frequency. The proposed system operation is implemented on a sample power grid comprising of generation, transmission and distribution and results are verified experimentally through the Opal-RT real-time simulation system.

Topic: Microgrid Control and Optimization
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
OBoW: Online Bag-of-Visual-Words Generation for Self-Supervised Learning

Learning image representations without human supervision is an important and active research field. Several recent approaches have successfully leveraged the idea of making such a representation invariant under different types of perturbations, especially via contrastive-based instance discrimination training. Although effective visual representations should indeed exhibit such invariances, there are other important characteristics, such as encoding contextual reasoning skills, for which alternative reconstruction-based approaches might be better suited.With this in mind, we propose a teacher-student scheme to learn representations by training a convolutional net to reconstruct a bag-of-visual-words (BoW) representation of an image, given as input a perturbed version of that same image. Our strategy performs an online training of both the teacher network (whose role is to generate the BoW targets) and the student network (whose role is to learn representations), along with an online update of the visual-words vocabulary (used for the BoW targets). This idea effectively enables fully online BoW-guided unsupervised learning. Extensive experiments demonstrate the interest of our BoWbased strategy, which surpasses previous state-of-the-art methods (including contrastive-based ones) in several applications. For instance, in downstream tasks such Pascal object detection, Pascal classification and Places205 classification, our method improves over all prior unsupervised approaches, thus establishing new state-of-the-art results that are also significantly better even than those of supervised pre-training. We provide the implementation code at https://github.com/valeoai/obow.

Topic: Multimodal Machine Learning Applications
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
PhUSE De-Identification Working Group: Providing De-Identification Standards to CDISC Data Models

In this era of Data Transparency and sharing data with researchers, companies are defining their processes and deidentification guidance in order to comply with data privacy regulations. In particular, it is possible for researchers to request access to data across sponsors and both the difference of data models and de-identification techniques may make the analyses cumbersome and error-prone. While the CDISC data models are now adopted in the industry, PhUSE launched in July 2014 a dedicated Working Group to define de-identification standards for CDISC data models starting with SDTM. Participants from Pharmaceuticals, CROs, Software Vendors, CDISC specialists, Data Privacy specialists and Academia have joined forces to define a set of rules against SDTM to provide the industry with a consistent approach to data deidentification and increase consistency across anonymized datasets. Each domains and variables holding potentially Personally Identifying Information (PII) have been rated in terms of impact on data privacy. Based on that rating the variables are allocated standard rules of de-identification, the rationale and the impact on data utility is documented., allocated rules to apply and their rationale and impact on data utility. This presentation will elaborate on the Working Group main findings, the current deliverables and the perspective to take this first initiative to the next stage.

Topic: Data Quality and Management
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
For What May the Aesthete Hope?

In this chapter, we argue that a distinct concept of “aesthetic hope” emerges from the way Kierkegaard’s Aesthete treats hope [Haab] and its relationship to recollection [Erindring] in “The Unhappiest One” and “Rotation of Crops.” We first show that aesthetic hope is distinct from the two other kinds of hope discussed by Kierkegaard: temporal hope and eternal hope. We then consider the suggestion that aesthetic hope is also an expression of despair – an inverse hope against hope, which seeks to avoid disappointment by hoping for things that are in some sense certain. The aesthete’s recommendation that we hope in such a way illuminates Kierkegaard’s view of the “dialectic” of temporal hope and eternal hope. Finally, we explore the treatment of hope in Either/Or as essentially involving a controlled, attentional element that anticipates some contemporary trends in the philosophy of hope.

Topic: Kierkegaardian Philosophy and Influence
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Plastid Phylogenomic Analyses Reveal the Taxonomic Position of Peucedanum franchetii

Peucedanum franchetii is a famous folk medicinal plant in China. However, the taxonomy of the P. franchetii has not been sufficiently resolved. Due to similar morphological features between P. franchetii and Ligusticopsis members, the World Flora Online (WFO) Plant List suggested that this species transformed into the genus Ligusticopsis and merged with Ligusticopsis likiangensis. However, both species are obviously diverse in leaf shape, bracts, and bracteoles. To check the taxonomic position of P. franchetii, we newly sequenced and assembled the plastome of P. franchetii and compared it with nine other plastomes of the genus Ligusticopsis. Ten plastomes were highly conserved and similar in gene order, codon bias, RNA editing sites, IR borders, and SSRs. Nevertheless, 10 mutation hotspot regions (infA, rps8, matK, ndhF, rps15, psbA-trnH, rps2-rpoC2, psbA-trnK, ycf2-trnL, and ccsA-ndhD) were still detected. In addition, both phylogenetic analyses based on plastome data and ITS sequences robustly supported that P. franchetii was not clustered with members of Peucedanum but nested in Ligusticopsis. P. franchetii was sister to L. likiangensis in the ITS topology but clustered with L. capillacea in the plastome tree. These findings implied that P. franchetii should be transferred to genus Ligusticopsis and not merged with L. likiangensis, but as an independent species, which was further verified by morphological evidences. Therefore, transferring P. franchetii under the genus Ligusticopsis as an independent species was reasonable, and a new combination was presented.

Topic: Plant and Fungal Species Descriptions
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
IMPROVING HEALTH LITERACY AMONGST SCHOOL AGE CHILDREN IN GRANVILLE AND VANCE COUNTIES BY ADDRESSING GRADE LEVEL PROFICIENCY AND DISPROPORTIONATE DISCIPLINARY ACTIONS.

Health literacy, the ability to obtain, understand, and apply health information, is a critical social determinant of health with lasting impact. For school-age children, especially in underserved communities, it influences lifelong health through behavior, care access, and disease prevention. Third grade reading proficiency is a strong predictor of future health literacy; without it, children face challenges understanding medical instructions, communicating with providers, and making informed health decisions. Low health literacy is linked to poor chronic disease management, low preventive care use, and higher rates of emergency visits and preventable hospitalizations. In North Carolina&rsquo;s Granville and Vance Counties, low reading scores, high suspension rates, and racial disparities in education threaten long-term health equity. Suspensions, particularly of Black students, disrupt learning and are tied to Adverse Childhood Experiences (ACEs), which increases the risk for chronic illness and mental health conditions. Poverty and limited access to healthcare further compound these challenges. Schools in both counties have introduced literacy and wellness initiatives, along with reforms like Positive Behavioral Interventions and Supports (PBIS) and restorative justice. However, more culturally responsive, trauma-informed strategies are needed. This paper advocates for integrated, community-driven interventions that prioritize health literacy as both a public health and educational goal. This is essential for advancing equity and improving outcomes in these rural communities.<br /><br /><strong>Keywords: </strong>Health, literacy, proficiency, suspensions. &nbsp; &nbsp;

Topic: Health Literacy and Information Accessibility
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Interactions in improvised music: people at play

Interactions in improvised music: people at play This project began as an open exploration of musical interactions in a trio in which I have played bass for many years. We gave three concerts for the project and I explored our interactions by talking with the pianist/bandleader and drummer after each concert. They described a broad range of interactions and explored a number of different conceptions of what entails a musical interaction. The musicians were keen to talk about the factors that motivate them to perform together, mainly the desire to play. Play, for them, is its own reward. They aim to collaborate in the moment of performance to create something fresh, rather than display their instrumental technique or present music that has been preconceived. An appreciation of this motivation is needed to understand their interactions in concert. Audience members were also interviewed after every performance. They each experienced the concerts differently, in a way that reflects their preoccupations and interests as much as it reflects the concert event. The research thus provides a view of individuals and their differences that contrasts with the body of music research focused on common experiences within particular musical cultures and the acquisition of the skills required to participate in those cultures. This practice-led research project was allowed to develop and find focus gradually in cycles of performances, interviews and analysis of interview transcripts, concurrent with an ongoing exploration of texts about doing research. Various interactions – during the performances and interviews, between the researcher and the interview transcripts and between the researcher and research texts – contributed to the project’s development. These interactions can be thought of as play between foreknowledge and the unknown. Accordingly, play as described by the musicians and as defined in hermeneutics, was actively pursued as a way of developing an appropriate methodology for the project.

Topic: Diverse Music Education Insights
Subfield: Music
Field: Arts and Humanities
Domain: Social Sciences