jimnoneill/paper-to-field-training huggingface dataset:
RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress

The Rho family of GTPases regulates many aspects of cellular behavior through alterations to the actin cytoskeleton [1-6]. The majority of the Rho family proteins function as molecular switches cycling between the active, GTP-bound, and the inactive, GDP-bound, conformations [1-6]. Unlike typical Rho family proteins, the Rnd subfamily members, including Rnd1, Rnd2, RhoE/Rnd3, and RhoH, are GTPase deficient, and thus expected to be constitutively active [7-10]. Here, we identify an unexpected role for RhoE/Rnd3 in the regulation of the p53-mediated stress response. We show that RhoE is a transcriptional p53 target gene, and that genotoxic stress triggers actin depolymerization, resulting in actin-stress fiber disassembly through p53-dependent RhoE induction. Silencing of RhoE induction in response to genotoxic stress maintains stress fiber formation and strikingly increases apoptosis, implying an antagonistic role for RhoE in p53-dependent apoptosis. We found that RhoE inhibits ROCK I (Rho associated kinase I) activity during genotoxic stress thereby suppressing apoptosis. We demonstrate that the p53-mediated induction of RhoE in response to DNA damage favors cell survival partly through inhibition of ROCK I-mediated apoptosis. Thus, RhoE is anticipated to function by regulating ROCK I signaling to control the balance between cell survival and cell death in response to genotoxic stress.

Topic: Cancer-related Molecular Pathways
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The validity of perceived physical fitness in adult men and women

This study investigated the perception of personal physical fitness in adult men and women by comparing a Perceived Physical Fitness Index (PPFI) with a composite index of measured fitness. Subjects were 106 volunteer adults 36-55 years of age. They completed the PPFI (a 7-point Likert-type scale) and were then assessed for body composition, cardiorespiratory endurance, muscular strength and endurance, and flexibility. A composite fitness score was compared with their PPFI score. Perceived fitness was significantly different than actual fitness (F (1,100) = 31.3, {dollar}p <{dollar} 0.001) and there was a significant gender difference (F (1,100) = 13.56, {dollar}p <{dollar} 0.001). However, a significant interaction (F (1,100) = 21.88, {dollar}p <{dollar} 0.0001) indicated that the difference between perceived and actual fitness was not consistent for males and females. Further analysis revealed that females were able to estimate their fitness level more accurately than males. The results indicate that perceived fitness is a valid indicator of actual fitness for women but not for men.

Topic: Physical Activity and Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
A new type of PLZT light valve for an image projector

A novel type of PLZT light valve fabricated by a green sheet process has been developed, and a prototype image projector incorporating this light valve was investigated. A PLZT matrix with internal electrodes was fabricated by a tape casting technique, and the feasibility of high definition was verified. The light valve exhibits no crosstalk-related problems, is easy to fabricate, and has a high-response speed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Electrowetting and Microfluidic Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Value recovery with customer dissatisfaction: A study of restaurant services in Pakistan

The present study was carried out to investigate the relationship between value recovery and customer satisfaction in restaurant settings of Pakistan through three justice components, ie distributive, interactional, and procedural justice. Primary data was gathered through a five-point likert scale questionnaire from 200 customers of different casual dining restaurants located in Rawalpindi and Islamabad, Pakistan. Correlation and regression analysis was carried out to check the effect of value recovery on customer satisfaction. Study findings suggest that value recovery through its three dimensions, namely, procedural, interactional and distributive justice significantly and positively effect customer satisfaction in the restaurant setting. Implications for casual dining restaurant managers are to provide training to restaurant serving staff with regard to customer dealing, customer complain handling, and the ways in which service failure could be avoided. Furthermore, restaurant serving staff should be given adequate remunerations for increasing their work motivation.

Topic: Customer Service Quality and Loyalty
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Issues in teaching and learning accounting among students who use English as a second language

Although accounting is perceived as a numerical discipline, previous research has produced useful insights suggesting that non-proficiency in English language affects accounting education among some Asian students. However, there is a gap in the literature in terms of understanding how exactly accounting lecturers encounter this problem in the classroom. Without a narration of the experiences of accounting lecturers, who are the frontliners in the accounting education process, understanding the issues involved and policy responses would be limited. The present study responds to this challenge by conducting interviews with lecturers who have many years’ experience in teaching accounting among Asian students in Malaysian Universities. Interview data were analyzed using thematic analysis which uncovered three themes and how they affect accounting education. First, these students have limited vocabulary and find it difficult to understand explanations of basic accounting concepts. Second, lack of confidence arises from limited vocabulary and limits students’ productive interactions with their teachers – active learning is thus severely hampered. Third, students shy away from theoretical aspects of accounting and only memorize formulas and steps which they regurgitate during examinations. Implications of these findings and policy recommendations are discussed at the end of the paper.

Topic: Accounting Education and Careers
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Future Developments in Forage Harvesting Machinery and Processing

&lt;div class="htmlview paragraph"&gt;Forage harvesting, processing and handling equipment research is currently underway which will improve commodity quality, produce “value -added” products from forages, reduce energy and labor requirements of the equipment and improve forage marketability. Technologies are described which could increase forage quality and value by removing it from the field sooner after it is mowed to minimize the risk of weather damage. Mechanisms and management strategies for reducing the labor and energy required for field processing and for improving the marketability of forages are also described.&lt;/div&gt;

Topic: Ruminant Nutrition and Digestive Physiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Study for how to reduce highway noise levels using TNM

Median barriers are widely used on roadways in the US. The purpose of this paper was to evaluate a median barrier performance in reducing traffic noise using the Traffic Noise Model version 2.5. For this study, median barriers were modeled on three different roadway configurations at grade, depressed, and elevated. The analysis results indicated that the range of insertion loss for a median barrier at grade was less than 1.5 dBA with a barrier height of 2.5 ft to 10 ft. The range of insertion loss for a median barrier on a depressed roadway (5 ft, 10 ft, and 20 ft below grade) was 0 dBA to 2.8 dBA with a barrier height of 2.5 ft to 4.5 ft and insertion loss increased up to 4.3 dBA with a taller barrier height of 6 ft to 10 ft. On an elevated roadway (5 ft, 10 ft, and 20 ft above grade), the range of insertion loss for a median barrier was 0 dBA to 1.7dBA with a barrier height of 2.5 ft to 10 ft. Given the results of this research, it is reasonable to conclude that a standard median barrier would not provide a significant level of noise reduction.

Topic: Transportation Safety and Impact Analysis
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
CCDC 239858: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Multidisciplinary projects for Engineering, Business Administration and Design programs: Construction and mapping of common skills through an analysis instrument

In Brazil the Engineering, Business Administration and Design courses have, each one of them, a list of own competences, or skills, that are established on the curricular guidelines by Ministry of Education, to be developed by students along the course. This is not a closed list, and specific competences attending specifics courses demands can be included, in order to training students with innovative and current profile. The engineering courses guidelines point out that students need to be trained with active learning strategies putting them as protagonists of their training and, besides this, courses need to make use of projects to develop the soft skills desirable in this training. To achieve an integrative approach, an institution created a new curriculum in which the students of these three courses interact in multidisciplinary projects. This approach has with bases the innovation tripod supporting the collaboration of the students of these three courses, aiming training them to a global scenario that claims professional’s broad vision. Each multidisciplinary project is developed in an academic semester and the students need to enrol in two projects per semester. In this context emerged the need of a convergent list of competences that translate the competences of these three courses, without lose the essence of each one. This paper presents the process of building this unique list of competences, for training professionals with an updated and innovative profile. From this, a survey was carried out to gather information on the competences developed in these projects. The research method was the documental analysis for the creation of the list of competences. To survey the competences that are offered in the projects, a questionnaire sent to the instructors was used. The list of competences allowed the creation of an activity plan, in which they declare the competences that will be developed by students, ensuring the management of the learning process.

Topic: Engineering Education and Curriculum Development
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
Practice makes perfect: reflections on a primary care treatment-to-target study

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.Practice makes perfect.. Reflections on a primary care treatment-to-target study

Topic: Primary Care and Health Outcomes
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Graph Coloring Heuristics for Optical Networks Planning

This work focuses on the study of wavelength assignment algorithms based on Graph Coloring techniques. We analyze the performance of the Greedy heuristic, a well-known Graph Coloring heuristic, as well as the Degree of Saturation (DSATUR) and the Recursive Largest First (RLF) heuristics, for planning optical networks. These last two heuristics, to the best of our knowledge, have not yet been applied in the context of optical networks. Extensive simulations have been performed, using real network topologies under a static traffic scenario and we have concluded that the DSATUR and RLF heuristics can outperform the Greedy heuristic in network scenarios where there are several network clusters interconnected by only one or two links. In these cases, the RLF and DSATUR heuristics can provide less 9 and 5 wavelengths, respectively, than the Greedy heuristic, in networks with 34 nodes.

Topic: Advanced Optical Network Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Distributed Algorithms in Membrane Systems

Membrane systems or P systems are distributed and parallel computing models, inspired by the interconnected structure and function of living cells. This thesis investigates the adequacy of synchronous membrane systems for modelling a set of fundamental distributed algorithms. This thesis provides a coherent approach to specify and analyse a certain class of problems related to distributed algorithms. This thesis presents a set of P algorithms (i.e. algorithms that are implemented using membrane systems) that are comparable (i.e. not necessarily better, but not much worse) to the corresponding distributed algorithms, expressed as high-level pseudocodes, with respect to time complexity and program-size complexity. This thesis introduces a new membrane system model. This new model incorporates features that allow for the reduction of inherent non-determinism (such as allowing for a total order priority on rule sets), allowing a better control of the rule execution strategy of the considered distributed algorithms, which are complex and require clear and well defined threads of execution. This thesis proves that this new model is Turing complete and universal. This thesis presents several broadcast- and echo-based P algorithms, as modular building blocks, for building more complex algorithms. These broadcast- and echobased P algorithms have time complexity of e+k and 2e+k, respectively, where e is the eccentricity of a source and k is an integer constant. Next, this thesis presents two solutions to the _ring squad synchronization problem (FSSP). The first FSSP solution synchronizes digraph-structured P systems in 3e+11 steps, where e is the eccentricity of the general. The second FSSP solution synchronizes tree-structured P systems in h+2r +5 steps, where h and r are the height and radius of the tree, respectively. Finally, this thesis presents solutions to two fundamental problems in graph theory: the edge- and node-disjoint paths problems. For a given membrane system with n cells and m links, these solutions find sets of edge- and node-disjoint paths of maximum cardinality in O(mn) steps. These solutions are the first P algorithms for solving the edge- and node-disjoint paths problems in membrane systems.

Topic: DNA and Biological Computing
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Abstract Obese pregnant women in late pregnancy are more susceptible to uterine smooth muscle dysfunction, but the underlying mechanisms remain elusive. Here, elevated levels of fatty acid binding protein 4 (FABP4) in the myometrium of obese pregnant women at term, high‐fat diet (HFD)‐induced obese mice, and palmitic acid‐treated uterine smooth muscle cells (USMCs), are demonstrated. FABP4 plays a critical role in transporting fatty acids from the extracellular to the intracellular compartment. Mechanistically, obesity promotes excessive fatty acid uptake, leading to aberrant lipid accumulation and reduced ATP production in USMCs. These abnormalities stem from weakened coupling of mitochondria‐associated membranes, which are essential for calcium, lipids, and metabolites exchange. Furthermore, adenoviral injection to elevate FABP4 levels in normal‐diet mice mimicks the effects observed in HFD mice. Collectively, these findings highlight FABP4 as a key driver of myometrial dysfunction in obesity and a potential therapeutic target for improving labor outcomes in obese pregnancies.

Topic: Peroxisome Proliferator-Activated Receptors
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Improved Association Rule Mining with Positive and Negative Integration

Association rule mining is used to find association relationships among large data sets. Mining frequent patterns is an important aspect in association rule mining. Finding frequent itemsets in databases is crucial in data mining for purpose of extracting association rules. Many algorithms were developed to find those frequent itemsets. Mining frequent patterns in transaction databases, time-series databases, and many other kinds of databases has been studied popularly in data mining research. Most of the previous studies adopt an Apriori-like candidate set generation-and-test approach. However, candidate set generation is still costly, especially when there exist a large number of patterns and/or long patterns. The FP-growth algorithm is currently one of the fastest approaches to frequent item set mining. In this paper, we proposed to compress the frequent pattern set mined from a transaction database to a compact set. The compact set is useful in application where the longest pattern is usually used.

Topic: Data Mining Algorithms and Applications
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Attitudes towards blood donation among students in different health sciences disciplines in Saudi Arabia.

The objective of this research undertaking was to examine the attitudes of King Khalid University undergraduates enrolled in various health disciplines regarding blood donation. Undergraduates of health disciplines participated in this study. The survey questions were administered through Google Forms, and the data was imported into GraphPad Prism for visualization and analytical purposes. A greater proportion of participants were male, with males accounting for 63.2% of the sample, while females accounted for 36.8%. The findings given in this research illustrate a wide range of attitudes regarding the practice of blood donation. A notable percentage of the participants had a favorable predisposition towards engaging in voluntary blood donation. Nevertheless, a significant degree of variability was observed among individuals with regards to their attitudes toward several variables, including fear, motivation, and their preferred location for making donations. The participants expressed negative attitudes against the practice of importing blood and the recognition of personal accountability in engaging in blood donation for the sake of society. One potential solution to address the unfavorable attitudes among students towards blood donation is the implementation of educational programs focused on blood donation and its associated benefits. Additionally, incorporating motivational strategies could further enhance the effectiveness of these initiatives. As a result, this could have a positive impact on students and those in their immediate vicinity.

Topic: Blood donation and transfusion practices
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Uniqueness of enhancements for derived and geometric categories

Abstract We prove that the derived categories of abelian categories have unique enhancements—all of them, the unbounded, bounded, bounded above and bounded below derived categories. The unseparated and left completed derived categories of a Grothendieck abelian category are also shown to have unique enhancements. Finally, we show that the derived category of complexes with quasi-coherent cohomology and the category of perfect complexes have unique enhancements for quasi-compact and quasi-separated schemes.

Topic: Algebraic structures and combinatorial models
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Data from Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles

&lt;div&gt;Abstract&lt;p&gt;Barasertib (AZD1152), a highly potent and selective aurora kinase B inhibitor, gave promising clinical activity in elderly acute myeloid leukemia (AML) patients. However, clinical utility was limited by the requirement for a 7-day infusion. Here we assessed the potential of a nanoparticle formulation of the selective Aurora kinase B inhibitor AZD2811 (formerly known as AZD1152-hQPA) in preclinical models of AML. When administered to HL-60 tumor xenografts at a single dose between 25 and 98.7 mg/kg, AZD2811 nanoparticle treatment delivered profound inhibition of tumor growth, exceeding the activity of AZD1152. The improved antitumor activity was associated with increased phospho-histone H3 inhibition, polyploidy, and tumor cell apoptosis. Moreover, AZD2811 nanoparticles increased antitumor activity when combined with cytosine arabinoside. By modifying dose of AZD2811 nanoparticle, therapeutic benefit in a range of preclinical models was further optimized. At high-dose, antitumor activity was seen in a range of models including the MOLM-13 disseminated model. At these higher doses, a transient reduction in bone marrow cellularity was observed demonstrating the potential for the formulation to target residual disease in the bone marrow, a key consideration when treating AML. Collectively, these data establish that AZD2811 nanoparticles have activity in preclinical models of AML. Targeting Aurora B kinase with AZD2811 nanoparticles is a novel approach to deliver a cell-cycle inhibitor in AML, and have potential to improve on the clinical activity seen with cell-cycle agents in this disease. &lt;i&gt;Mol Cancer Ther; 16(6); 1031–40. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: Microtubule and mitosis dynamics
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Neoliberalismo y educación

The aim of this article is to analyze Neoliberalism as an ideology that is part of globalization and its relationship with present educaction –the new neoliberal school-, in which the student –homo sapiens- become a “homo videns”, as a result of the licentiousness caused by Neoliberalism.

Topic: Employment, Labor, and Gender Studies
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences