jimnoneill/paper-to-field-training huggingface dataset:
High-fat diet-induced deSUMOylation of E4BP4 promotes lipid droplet biogenesis and liver steatosis in mice

&lt;p&gt;Dysregulated lipid droplet accumulation has been identified as one of the main contributors to liver steatosis during nonalcoholic fatty liver disease (NAFLD). However, the underlying molecular mechanisms for excessive lipid droplet formation in the liver remain largely unknown. In the current study, hepatic E4 promoter-binding protein 4 (E4BP4) plays a critical role in promoting lipid droplet formation and liver steatosis in a high-fat diet (HFD)-induced NAFLD mouse model. Hepatic &lt;em&gt;E4bp4&lt;/em&gt; deficiency (&lt;em&gt;E4bp4-LKO&lt;/em&gt;) protects mice from HFD-induced liver steatosis independently of obesity and insulin resistance. Our microarray study showed a markedly reduced expression of lipid droplet binding genes such as &lt;em&gt;Fsp27&lt;/em&gt; in the liver of &lt;em&gt;E4bp4-LKO&lt;/em&gt; mice. E4BP4 is both necessary and sufficient to activate &lt;em&gt;Fsp27&lt;/em&gt; expression and lipid droplet formation in primary mouse hepatocytes. Overexpression of &lt;em&gt;Fsp27&lt;/em&gt; increased lipid droplets and triglycerides in &lt;em&gt;E4bp4-LKO&lt;/em&gt; primary mouse hepatocytes and restored hepatic steatosis in HFD-fed &lt;em&gt;E4bp4-LKO&lt;/em&gt; mice. Mechanistically, E4BP4 enhances the transactivation of &lt;em&gt;Fsp27&lt;/em&gt; by CREBH in hepatocytes. Furthermore, E4BP4 is modified by SUMOylation and HFD feeding induces deSUMOylation of hepatic E4BP4. SUMOylation of five lysine residues of E4BP4 is critical for the downregulation of &lt;em&gt;Fsp27 &lt;/em&gt;and lipid droplets by the cAMP signaling in hepatocytes. Taken together, this study revealed that E4BP4 drives liver steatosis in HFD-fed mice through its regulation of lipid-droplet binding proteins. Our study also highlights the critical role of deSUMOylation of hepatic E4BP4 in promoting NAFLD. &lt;/p&gt;

Topic: Lipid metabolism and biosynthesis
Subfield: Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Warfarin Dosing in a Patient with CYP2C9∗3∗3 and

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Genetic factorsmost correlatedwithwarfarin dose requirements are variations in the genes encoding the enzymes cytochromeP450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR). Patients receiving warfarin who possess one or more genetic variations inCYP2C9 andVKORC1 are at increased risk of adverse drug events and require significant dose reductions to achieve a therapeutic international normalized ratio (INR). A 74-year-old white female with atrial fibrillation was initiated on a warfarin dose of 2mg PO daily, which resulted in multiple elevated INR measurements and three clinically significant hemorrhagic events and four vitamin K antidote treatments over a period of less than two weeks. Genetic analysis later revealed that she had the homozygous variant genotypes of CYP2C9∗3∗3 and VKORC1-1639 AA. Warfarin dosing was subsequently restarted and stabilized at 0.5mg PO daily with therapeutic INRs.This is the first case report of a white female with these genotypes stabilized onwarfarin, and it highlights the value of pharmacogenetic testing prior to the initiation of warfarin therapy to maximize efficacy and minimize the risk of adverse drug events. 1.

Topic: Pharmacogenetics and Drug Metabolism
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
African American couples : socio-cultural factors impacting marriage trends, reflections on marriageability, and a systematic review of culturally grounded couple and marriage relationship intervention

Racial and ethnic minority couples experience unique relationship discord factors; yet, marriage and couple approaches have not intentionally targeted racial/ethnic minorities, especially African American couples who are disproportionately impacted by relationship dissolution. Research shows African American couples persevere through marital discord by relying on protective factors unique to their culture; these factors are a strong sense of community, supportive family, kinship, and ideals focused around spirituality and culture. Although this is true, few studies have systematically analyzed the extent to which current relationship intervention programs integrate cultural components unique to African Americans to effectively reduce relationship discord for African American couples. This dissertation forms a comprehensive body of literature by examining the socio-cultural factors impacting African American relationships, exploring African American women’s reflections about marriageability, and evaluating the cultural components of interventions to reduce African American relationship discord. The first article utilizes a historical-ecological perspective to review the scholarly discourse on marriage and relationship trends among African American couples, and delineates socio-cultural factors which collectively have contributed to declining marriageability rates for African American couples over the past 12 decades. The second article is a phenomenological study of young, African American female students’ blogs about the current marriage/relationship trends. The women expressed frustration about the low marriageability rates and suggested culturally relevant marriage and relationship interventions as instrumental to fostering healthy African American marriages. The third article presents a systematic review of African American couples relationship education (CRE) and marriage relationship education (MRE) programs incorporating Africentric theory or cultural factors as a theoretical underpinnings. Seven studies of four curriculum-based interventions used with African American couples demonstrated that inclusion of Africentric or culturally grounded components contribute to the effectiveness of CRE/MRE programs with African American couples by promoting culturally- relevant healthy relationship skills. Further, the impact of socio-cultural-historical factors on African American relationships was an integral component to the effectiveness of the CRE/MRE programs. This dissertation contributes to a virtually untouched research area by delineating the decades-long socio-cultural-historical factors impacting African American marriages, uncovering the insights of African American women, and systematically examining how Africentric and other culturally-grounded components foster effective couples interventions for African American couples.

Topic: Family Dynamics and Relationships
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
Int. J. Human-Computer Studies n M

fo ine ent ts b phones can help bridge the gap between internet and mobile services, and expand the number of potential blog readers. Since mobile phone customers to use their mobile phones to track blog limited number of documents and to deliver them to all 1.1. Comparison of personal computer and mobile phone features associated with blog reading ARTICLE IN PRESSThe large majority of web content is aimed at PC surfers rather than mobile phone users, and most blog document 1071-5819/ $- see front matter &amp;amp; 2010 Elsevier Ltd. All rights reserved. doi:10.1016/j.ijhcs.2010.03.005 Corresponding author.

Topic: Lepidoptera: Biology and Taxonomy
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Unconventional correlated insulator in CrOCl-interfaced Bernal bilayer graphene

Gap opening in a wide-enough doping range, whilst keeping high conductance outside this gapped state, has remained a grand challenge in graphene since decades. Here, we show a unique heterostructure of Bernal-stacked bilayer graphene (BLG) atop few-layered CrOCl, which enables a surface state in CrOCl under vertical electric fields, and it promotes electron-electron(e-e) interactions in BLG via Coulomb long ranged coupling. Consequently, at the charge neutral, a crossover from single particle insulating behavior to an unconventional correlated insulator is seen, below a critical temperature. The over1 GΩ insulating ground state exists in a widely accessible gate range, and can be switched into a metallic state with an on/off ratio up to 10<sup>7</sup>, by applying an in-plane electric field, heating, or by gating. A logic inverter using such correlated insulator is demonstrated, despite that it works still at low temperature. Our findings of the correlated insulating phase in CrOCl/BLG heterosystem paves the way for future engineering of exotic quantum electronic states in the paradigm of interfacial charge coupling.

Topic: Graphene research and applications
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Radiation quality of cosmic ray nuclei studied with Geant4-based simulations

In future missions in deep space a space craft will be exposed to a non-negligible flux of high charge and energy (HZE) particles present in the galactic cosmic rays (GCR). One of the major concerns of manned missions is the impact on humans of complex radiation fields which result from the interactions of HZE particles with the spacecraft materials. The radiation quality of several ions representing GCR is investigated by calculating microdosimetry spectra. A Geant4-based Monte Carlo model for Heavy Ion Therapy (MCHIT) is used to simulate microdosimetry data for HZE particles in extended media where fragmentation reactions play a certain role. Our model is able to reproduce measured microdosimetry spectra for H, He, Li, C and Si in the energy range of 150-490 MeV/u. The effect of nuclear fragmentation on the relative biological effectiveness (RBE) of He, Li and C is estimated and found to be below 10%.

Topic: Radiation Therapy and Dosimetry
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Dualities and loops on squashed $S^3$

We consider $\mathcal{N}=4$ supersymmetric gauge theories on the squashed three-sphere with six preserved supercharges. We first discuss how Wilson and vortex loops preserve up to four of the supercharges and we find squashing independence for the expectation values of these $\frac{2}{3}$-BPS loops. We then show how the additional supersymmetries facilitate the analytic matching of partition functions and loop operator expectation values to those in the mirror dual theory, allowing one to lift all the results that were previously established on the round sphere to the squashed sphere. Additionally, on the squashed sphere with four preserved supercharges, we numerically evaluate the partition functions of ABJM and its dual super-Yang-Mills at low ranks of the gauge group. We find matching values of their partition functions, prompting us to conjecture the general equality on the squashed sphere. From the numerics we also observe the squashing dependence of the Lee-Yang zeros and of the non-perturbative corrections to the all order large $N$ expression for the ABJM partition function.

Topic: Black Holes and Theoretical Physics
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Off- pump coronary artery bypass grafting in cerebral infarction patients

【Objective】To study the safety of off- pump coronary artery bypass grarting (OPCAB) in patientswith cerebral infarction. 【Methods】From Feb. 2000 to May 2004, nine patients with chronic cerebral infarctionunderwent OPCAB. Postoperative cerebral complications were analyses and all patients were checked by CT scanpostoperatively. 【Resurts】Postoperative course was uneventful in all patients. There were no any symptoms includ-ing headache, vomit, hemipegia, alogia, hemiopia on postoperative. CT scan on the fourth postoperatively day showedthat the chronic in farction areas were not increased and no new infarction was found. 【Conclusions】OPCAB is asafe and effective method for patients with chronic carebral infarction.

Topic: Cardiac and Coronary Surgery Techniques
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Examining quality of care for individuals treated for mental health using the HEDIS mental health quality measures

<b>Objective:</b> This descriptive study examined the quality of care received by individuals with serious mental illness observed in clinical care using established Healthcare Effectiveness Data and Information Set (HEDIS) measures for individuals with serious mental illness.<b>Methods:</b> Administrative claims (Medicaid, Medicare, and commercial) from a national health and well-being company were used to identify adults with schizophrenia or bipolar disorder. Performance rates for five HEDIS mental health quality measures were computed. Sub-group analyses examined each HEDIS measure by those who were medication adherent vs non-adherent, and by typical vs atypical antipsychotics.<b>Results:</b> Eighty-nine percent of the Medicaid population received a diabetes screening (vs 79% for national benchmark Medicaid rates), 81% (vs 69%) received monitoring for diabetes, 88% (vs 79%) received monitoring for cardiovascular disease, 63% (vs 60%) were adherent with antipsychotic medication, and 34% (vs 61%) had a follow-up visit with a mental health practitioner within 30 days of a discharge. The rates for individuals with Medicare coverage were similar or marginally higher than those reported for those with Medicaid coverage, while rates for the commercially insured population were lower than the other groups.<b>Conclusions:</b> Most (>65%) individuals with serious mental illness received the recommended screening and monitoring for diabetes and cardiovascular disease. Barriers to and reasons for lack of follow-up should be investigated to guide future interventions to improve follow-up after hospitalization for individuals with serious mental illness.

Topic: Schizophrenia research and treatment
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Design and Testing of a Crawler-Type Orchard Air-Assisted Electrostatic Sprayer

To address the challenges of low mobility and difficulty in depositing pesticide droplets on the backside of fruit tree leaves, this study proposes a method combining a crawler-type chassis with an electrostatic spraying system to design a crawler-type air-assisted electrostatic orchard sprayer. The developed crawler-type chassis meets the operational environmental requirements of the sprayer, with both operating speed and mobility achieving the design goals. Test results show that the designed air-assisted electrostatic nozzle can achieve a charge-to-mass ratio of 1.0 mC/kg at the outlet. The droplet coverage on the front side of leaves with electrostatic spraying is slightly lower than that of non-electrostatic spraying, but the coverage on the backside is higher. This research provides a reference for the design and application of air-assisted electrostatic sprayers.

Topic: Plant Surface Properties and Treatments
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Screening and diagnosis of gestational diabetes mellitus: critical appraisal of the new International Association of Diabetes in Pregnancy Study Group recommendations on a national level. Diabetes Care 2012;35:1894–1896

Kalter-Leibovici O, Freedman LS, Olmer L, Liebermann N, Heymann A, Tal O, Lerner-Geva L, Melamed N, Hod M. Screening and …

Topic: Gestational Diabetes Research and Management
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Characteristic magnetizations of paleomagnetic samples from ODP Leg 103

Lower Cretaceous and Tithonian sediments were sampled for magnetostratigraphy at six holes (Holes 638B, 638C, 639A, 639D, 640A, and 641C). Magnetic polarity chrons were assigned to polarity zones using biostratigraphic constraints.In Holes 638B and 638C, polarity Chrons M3 and perhaps Ml are present in the upper part, M4 and M5 are apparently absent, M6 through M9 are poorly represented, M10 and M10N are apparently absent, and Ml 1 and M12 are tentatively assigned to the lower part. Strata in Holes 638B and 638C dip toward the south.In Hole 639A, polarity Chron M13 is well documented and M12A may be present. In Hole 639D, polarity Chrons M19 through M21 may be present, but the data is poor. Hole 640A had inadequate recovery to identify polarity chrons. In Hole 641C, polarity Chron MO is well documented and occurs significantly above the nannofossil marker of the Barremian/Aptian boundary; comparison to Italian magnetostratigraphy implies that this nannofossil datum is timetransgressive.

Topic: Geomagnetism and Paleomagnetism Studies
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Unrecognized intrauterine toxoplasmosis despite screening].

A female small for date infant (BW 1500 g) was delivered after uncomplicated pregnancy in the 36th week of gestation. On routine screening for toxoplasmosis a negative SFT had been obtained in the 13th week of gestation. The second examination in the 32nd week was positive (SFT 1:16384). The mother was then put on specific chemotherapy (sulfametoxydiazine and pyrimethamine). The infant, however, had severe- and characteristic lesions (cerebral calcifications, chorioretinitis) not responding to therapy. Morphology of the lesions and serology led to the conclusion that the infant was infected between the 17th and the 24th week of gestation and that the disease remained undetected until the 32nd week, when treatment came already too late. This indicates that in case of a negative test further serological examinations should be carried out at closer intervals to establish the diagnosis in due time.

Topic: Toxoplasma gondii Research Studies
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
A Comparison of the Effectiveness of Reciprocating System with Continuous Rotary Systems in Non-Surgical Endodontic Retreatment : An in Vitro Study

Background: Optimal root canal retreatment was required safe and efficient removal of filling material from root canal. The aim of this in vitro study was to compare the efficacy of reciprocating and continuous motion of four retreatment systems in removal of root canal filling material. Materials and Methods: Forty distal roots of the mandibular first molars teeth were used in this study, these roots were embedded in cold clear acrylic,roots were instrumented using crown down technique and rotary ProTaper systemize Sx to size F2 ,instrumentation were done with copiousirrigation of 2.5% sodium hypochlorite and 17% buffered solution of EDTA was used as final irrigant followed by distilledwater, roots were obturated with AH26 sealer and Protaper gutta-percha point F2 and medium fine accessory gutta-percha using lateral condensation technique,roots were left for 7 days with 100% humidity at 37ºC in an incubator. Roots were randomly divided into four groups according to technique used for removing the root filling material (ten teeth for each group): group I: reciprocating technique and Wave One system, group II: continuous technique and ProTaper retreatment system, group III: continuous technique and R-Endo system, group IV: continuous technique and D–RaCere treatment system. All the roots were radiographed before and after removal of gutta-percha from both bucco-lingual and mesiodistal directions using custom made platform and digital radiograph system RVG to havea digitized images. The total surface area of all root canals was measured before removal ofthe gutta-percha and the area of the remaining gutta-percha filling in the canals after retreatment procedure from both directions. These measurements were analyzed with Adobe Photoshop CS6 software, the percentage of removed gutta-percha calculated. Results: Statistical analysis was performed and the result showed group Ihad the highest mean values in removal of root canal filling material in both bucco-lingual and mesiodistal direction of dental radiograph and there were significant difference between group I and most of the other groups ,there were non significant difference between group II,group III and group IV. Conclusion: This study was showed all the used retreatment systems did notcompletely remove the root canal filling material. The reciprocating technique was most effective method for removing gutta-percha and sealer than continuous rotary technique. Key words: Retreatment, reciprocating motion, root canal filling, rotary instrument.

Topic: Endodontics and Root Canal Treatments
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Solvent Effect on the Product Distributions in the Photocycloaddition of Electron-rich Olefins to 1,2-Naphthoquinone

Abstract Irradiation of 1,2-naphthoquinone in the presence of electron rich olefins such as 2-methoxypropene, ethyl vinyl ether, or 2,3-dihydrofuran, afforded two isomers of cycloadducts, i.e., dihydrodioxins and dihydrofuran derivatives. The distributions of these two products strongly depended on the solvent polarities. In the reaction in benzene, dihydrodioxins were almost exclusively obtained, whereas in acetonitrile or methanol dihydrofuran derivatives were exclusively produced in high yields.

Topic: Oxidative Organic Chemistry Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Impact of Aging on Risk of Hypoglycemia in Patients with Type 1 Diabetes

Background: As T1D patients routinely reach older age, more information is needed to understand the impact of aging on the risk of hypoglycemia and its interaction with other age-related issues. Methods: We evaluated 2 groups of patients with T1D: older (age &amp;gt;65 years) and younger (age 18-35 years). All patients were subjected to either blinded CGM for 2 weeks or assessment of personal CGM. A hypoglycemia fear survey (HFS II), and a Clarke hypoglycemia unawareness survey were completed. Patients were also assessed for cognitive function by the Montreal Cognitive Assessment (MoCA). Glycemic control was measured by A1C. Results: We evaluated 56 patients with T1D; 23 in the older and 33 in the younger group. The average age was 70 vs. 28 years; diabetes duration 36 vs. 14 years; A1C 8.0% vs. 7.9%, respectively. Clinically significant hypoglycemia (glucose ?54 mg/dL for &amp;gt; 15 mins/episode) occurred equally in 91% of older (mean 28 minutes/day) and 88% of younger (mean 23 mins/day) patients. Older patients reported hypoglycemia unawareness more (39% vs. 30%), with similar scores on HSF II (34 vs. 33). However, 61% of older patients had cognitive impairment (MoCA score &amp;lt;26) compared to 12% in younger adults. There was a higher comorbidity burden in older patients (average number of comorbidities 4 vs. 1), with a higher number of daily medications (10 vs. 4). Conclusion: The risk of hypoglycemia is similar in older and younger patients with T1D. However, higher incidence of comorbidities including cognitive dysfunction and polypharmacy may increase the risk of poor outcomes due to hypoglycemia. Disclosure M. Munshi: Consultant; Self; Sanofi. C. Slyne: None. A. Atakov-Castillo: None. J. Greenberg: None. T. Greaves: None. S.P. Carl: None. E. Toschi: None.

Topic: Diabetes Management and Research
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences