jimnoneill/paper-to-field-training huggingface dataset:
Konsep Life Skills dalam Pembelajaran Bahasa Arab di Madrasah

This research uses qualitative descriptive approaching method and use study case research type. The data obtained from primary and secondary data sources, which data collection techniques are observation, interview, and documentation. The results of the research stated that in the life skill education design in the Arabic Language Learning at MI NU Tamrinut Thullab Undaan Kudus are: The aspects of life skills that will be developed are integrated and will be a part of the basic competencies that must be pursued accomplished with the achievement skills derived from the substance of the subject matter of Arabic Language Learning which is outlined into Prota, Promes, SK and KD Mapping, Syllabus, and RPP form. Implementation of life skill education in Arabic Language Learning at MI NU Tamrinut Thullab Undaan Kudus; according to the physiological and psychological level of students at the MI, it is emphasized on efforts to develop generic skills such as personal skills and social skills. While the supporting factors in the Life Skill Education implementation in Arabic Language Learning at MI NU Tamrinut Thullab Undaan Lor Undaan Kudus are: (1) Madrasah Religious Program; (2) Self Development Program in Madrasah; (3) Madrasah Cultural Development Program; (4) Most students have been studied at Diniyyah / TPQ. Whereas, the obstacles factors in the life skills education implementation in Arabic Language Learning at MI NU Tamrinut Thullab Undaan Lor Undaan Kudus are: (1) The lack of funds and facilities; (2) Educators are less motivated to be creative and innovative for using and developing learning strategies.

Topic: Education and Character Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Demographic characteristics of individuals and the measurement of lifetime income

This paper argues that, in order to account for variations over the life-cycle in the level of material well-being of individuals, the income concept which ought to be used is that of household income per person with the individuals being classified by their own age and not by the age of the household head. Using data from the Socioeconomic Surveys for Thailand, the paper shows the differences in the age-income profiles corresponding to the following concepts: household income by age of head, household income per person by age of head, and household income per person by age of the individual. Life-cycle effects on the distribution of income will be quite different depending on which of these concepts is used in the analysis. The paper attempts to define lifetime income which is independent of life-cycle variations as the annual average of gross current income over the life of the individual, where household income per person is used. Where data permits we would adjust the income-by-age data to reflect the survival probabilities of individuals to different ages. The paper illustrates how different survival probabilities for different socioeconomic groups imply that the adjustment affects their lifetime incomes to different extents.

Topic: Income, Poverty, and Inequality
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
CCDC 836482: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Faculty Opinions recommendation of Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice.

Spinal cord injury usually results in permanent paralysis because of lack of regrowth of damaged neurons. Here we demonstrate that adult mice lacking EphA4 (-/-), a molecule essential for correct guidance of spinal cord axons during development, exhibit axonal regeneration and functional recovery after spinal cord hemisection. Anterograde and retrograde tracing showed that axons from multiple pathways, including corticospinal and rubrospinal tracts, crossed the lesion site. EphA4-/- mice recovered stride length, the ability to walk on and climb a grid, and the ability to grasp with the affected hindpaw within 1-3 months of injury. EphA4 expression was upregulated on astrocytes at the lesion site in wild-type mice, whereas astrocytic gliosis and the glial scar were greatly reduced in lesioned EphA4-/- spinal cords. EphA4-/- astrocytes failed to respond to the inflammatory cytokines, interferon-gamma or leukemia inhibitory factor, in vitro. Neurons grown on wild-type astrocytes extended shorter neurites than on EphA4-/- astrocytes, but longer neurites when the astrocyte EphA4 was blocked by monomeric EphrinA5-Fc. Thus, EphA4 regulates two important features of spinal cord injury, axonal inhibition, and astrocytic gliosis. PMID: 15537875

Topic: Axon Guidance and Neuronal Signaling
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Comparison of Cationic Propyl Gallate and Adenosine Diphosphate for the Meassurement of Aspirin Effectivity with Optical Aggregometry.

Abstract Background. The goal of our interest is to bring attention to standardisation of the aspirin effectiveness examination in patients profiting from (life)long antithrombotic terapy. Optical platelet aggregation tests have been most widely used. Examination with endogenous inductors of platelet aggregation - thrombin, colagen, arachidonic acid, adenosine diphosphate (ADP) has a low specificity and reproducibility. Aim. To compare a newer inductor of platelets aggregation cationic propyl gallate (CPG) with ADP for the examination of aspirin (ASA) efffectivity with optical aggregometry. Methods. We prospectively enrolled 116 consecutive patiens with a stable cardiovascular disease on ASA 100mg/day for ≥ 1 month. The controll group was formed from 62 healthy volunteers, without antithrombotic treatment. Analysis. We investigated platelet aggregation by optical aggregometry (aggregometer LASER 4x, BIOART). CPG and ADP were added as aggregating agents. The measured parameter were: CPG-slope (this parameter expresses steepness of the aggregation curve and also the speed of aggregation (%/minutes)) and ADP-max (the maximum percent change in light transmittance from baseline). Results. Definition. First, we determined the CPG-slope cut-off value for the definition of ASA-non-effective treated patient. We established it on the ground of CPG-slope values in the control group. The values from controll group followed a normal distribution (test Shapiro - Wilk). We calculated the cut-off value using the 95% - confidence interval. The CPG-slope cut-off value was 79 %/min for ASA-effective treated patient. We marked the patients as ASA-non efffective treated when the CPG-slope was ≥ 79%/min. The same way we used to define the cut-off value for ADP-max. We identified the aspirin treatment as uneffective when the value of ADP-max had been &gt; 62%. Comparison. The values of CPG-slope and ADP-max were in a close correlation in the group of patients treated with aspirin. The correlation index (r = 0,671) was highly significant. By CPG-induced optical aggregation were 33,6% ASA-non-effective treated patients. While using both inductors (CPG, ADP) were the proportion of ASA-non-effective treated patients 25%. By both tests (CPG, ADP) were equally divided 71,6% patients. ASA-non-effective treated patients were more commonly obese (46,2%) with hypertension (94,9%) and hypercholesterolemia (73,7%) and were less commonly treated with statins (30,8%) as the aspirin effective treated patients (42,%, 88,2%, 59,2% resp.42,1%). Conclusion. Meassurement of a platelet aggregation by CPG is reproducible with high sensitivity and specificity. The study has also brought attention to the importance of control the cardiovascular risk factors. Figure. Statistical parameters Figure. Statistical parameters

Topic: Antiplatelet Therapy and Cardiovascular Diseases
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Insectival antibacterial peptides antitumor activity,nude mice bearing,human cervical cancer cell line SiHa

Spodoptera frugiperda egg cell line(SF-9) were induced with LPS.The insectival antibacterial peptides were recovered by trichloroacetic acid precipitation method,and the antibacterial activity was determined using the zone inhibition assay.They generated obvious inhibition zone.In vitro,antibacterial peptides can inhibit the proliferation of human cervical cancer cell line SiHa.An in vivo analysis in nude mice with tumor xenografts was established to conduct interference treatment.Antibacterial peptides were injected intratumorally.The treatment groups showed marked difference from the control group(P0.01).Overall,these results indicated that the insectival antibacterial peptides were produced and possesses the potential to be a novel therapeutic agent for treating cervical cancer.

Topic: Insect Utilization and Effects
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Supplementary Tables 1-5 from Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression

&lt;p&gt;Supplementary tables of the revised manuscript.&lt;/p&gt;

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Action Grammars of Human Behavior – Measurement, Evolution, and Neural Representation

Abstract Human behaviors from tool-making to language are thought to rely on a uniquely evolved capacity for hierarchical action sequencing. Testing this idea will require objective, generalizable methods for measuring the structural complexity of real-world behavior. Here we present a data-driven approach for extracting action grammars from basic ethograms, exemplified with respect to the evolutionarily-relevant behavior of stone tool-making. We analyzed sequences from the experimental replication of ~2.5 Mya Oldowan vs. ~0.5 Mya Acheulean tools, finding that, while using the same “alphabet” of elementary actions, Acheulean sequences are quantifiably more complex and Oldowan grammars are a subset of Acheulean grammars. We illustrate the utility of our complexity measures by re-analyzing data from an fMRI study of stone tool-making to identify brain responses to structural complexity. Beyond specific implications regarding the co-evolution of language and technology, this exercise illustrates the general applicability of our method to investigate naturalistic human behavior and cognition.

Topic: Language and cultural evolution
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
In Vitro and in Vivo Studies on the Angiotensin-Converting Enzyme Inhibitory Activity Peptides Isolated from Broccoli Protein Hydrolysate

In the present study we purified and identified peptides from broccoli protein hydrolysates and evaluated their angiotensin-converting enzyme (ACE) inhibitory activity in vitro and hypotensive effect in vivo. Three ACE inhibitory peptides were isolated and identified as IPPAYTK, LVLPGELAK, and TFQGPPHGIQVER, and their inhibitory IC<sub>50</sub> values were 23.5, 184.0, and 3.4 μM, respectively. We then investigated the effect of gastrointestinal digestion on ACE inhibitory activity. We detected almost two times the ACE inhibitory activity of the peptide LVLPGELAK following simulated digestion than prior to digestion. LVLPGE and LAK, two novel peptides exhibiting high ACE inhibitory activity, were discovered following digestion and possessed IC<sub>50</sub> values of 13.5 and 48.0 μM, respectively. The hypotensive effect of the peptides was assessed after oral administration to spontaneous hypertensive rats (SHRs). We found that LVLPGE and LAK demonstrated a significant hypotensive effect in vivo. Protein from broccoli may thus constitute a potential antihypertensive peptide source.

Topic: Protein Hydrolysis and Bioactive Peptides
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Opportunities and combinations of chinese "Belt and Road" initiative for national economies of Southeast Asia

Initially, the Belt and Road initiative was greeted with enthusiasm in Southeast Asia, as it made possible to support projects and bring the products from Southeast Asia to international markets. However, the overwhelming number of projects in Indonesia, Malaysia, Laos, Philippines, and Thailand are experiencing significant difficulties,and none of them has been completed. China’s main volumes of investments and loans are allocated exclusively for infrastructure projects, while serious funds are not allocated for innovative industrial facilities or IT structures. Railroads and logistics facilities will be used to export Chinese goods to these countries, import raw materials to China, or deliver local industry products. The economic feasibility and quality of investments in projects in Indonesia and Malaysia are in great doubt. Laos and Myanmar are taking loans from China to develop the railway network without developing their own industry, so these regions can only be traders of Chinese goods. These countries cannot recoup the projects at all, many of them turn out to be unfinished, and therefore the debt to China is growing. The mega-project of the South China-Southeast Asia corridor was not economically sustainable. Its economic feasibility for the participating countries (except for China itself) raises many questions.

Topic: Peacebuilding and International Security
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Thyroid Function Abnormalities in Patients with Chronic Kidney Disease

The function of the thyroid gland is one of the most important in the human body as it regulates the majority of the body's physiological actions. The thyroid produces hormones (T3 and T4) that have many actions including metabolism, development, protein synthesis, and the regulation of many other important hormones. There is a lot of interaction between the kidney and thyroid gland during the disease States thyroid hormones have a major role in regulating the glomerular filtration rate through its hormonal actions in normal physiology. But these things are altered in the disease States such as chronic kidney disease. It is a well-known fact that hypothyroidism causes decreased Glomerular filtration rate whereas hyperthyroidism causes increased Glomerular filtration rate leading to renin-angiotensin-aldosterone system activation. In our study we aim to see the prevalence of low T3 syndrome in different stages of CKD which is a state of physiological benefit in preserving the proteins lost through the Kidneys in CKD patients and since CKD is progressed in hyperthyroidism state it is a protective mechanism in restoring the CKD status. Other subclinical hypothyroidism hyperthyroidism. Autoimmune hypothyroidism. Glomerulonephritis are all part of a dynamic endocrine and nephrology sequence. Thorough knowledge of these is required for optimum treatment of thyroid in CKD patients.

Topic: Birth, Development, and Health
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
A Deep Learning Approach for Chromium Detection and Characterization from Soil Hyperspectral Data

High levels of chromium (Cr) in soil pose a significant threat to both humans and the environment. Laboratory-based chemical analysis methods for Cr are time consuming and expensive; thus, there is an urgent need for a more efficient method for detecting Cr in soil. In this study, a deep neural network (DNN) approach was applied to the Land Use and Cover Area frame Survey (LUCAS) dataset to develop a hyperspectral soil Cr content prediction model with good generalizability and accuracy. The optimal DNN model was constructed by optimizing the spectral preprocessing methods and DNN hyperparameters, which achieved good predictive performance for Cr detection, with a correlation coefficient value of 0.79 on the testing set. Four important hyperspectral bands with strong Cr sensitivity (400–439, 1364–1422, 1862–1934, and 2158–2499 nm) were identified by permutation importance and local interpretable model-agnostic explanations. Soil iron oxide and clay mineral content were found to be important factors influencing soil Cr content. The findings of this study provide a feasible method for rapidly determining soil Cr content from hyperspectral data, which can be further refined and applied to large-scale Cr detection in the future.

Topic: Chromium effects and bioremediation
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.

A flat perfusion chamber was developed to study the interaction of blood platelets in flowing blood with cultured human vessel wall cells, their connective tissue matrix, and isolated connective tissue components at defined shear rate conditions. A cover slip covered with endothelial cells or extracellular matrix components was introduced into the chamber. Laser-Doppler velocimetry showed a symmetrical flow profile at flow rates between 50 and 150 ml/min (wall shear rate 300 to 1100 sec-1). Platelet deposition was estimated by using blood platelets labeled with indium-111 or by a morphometric method. Blood platelets did not adhere to endothelial cells at wall shear rates of 765 sec-1 and the endothelial cells remained attached for at least 10 min of perfusion. In preconfluent cultures of endothelial cells, blood platelets adhered to extracellular material in areas between the cells. Removal of endothelial cells by treatment with 0.5% Triton X-100 induced increased platelet adherence with a preference for certain, as yet unidentified, fibrillar structures of the extracellular matrix. Platelet adherence to equine collagen was also studied after coating the cover slips by spraying of small collagen droplets followed by air drying. Platelet adherence and the subsequent platelet aggregate formation occurred predominantly along visible collagen fibers. These studies showed that this perfusion chamber has a laminar and symmetrical flow allowing qualitative and quantitative investigation of platelet interaction with endothelial cells, their extracellular matrix, and pure connective tissue components. A variety of wall shear rates and exposure times can be applied at controlled conditions without removing cells or extracellular material.

Topic: Venous Thromboembolism Diagnosis and Management
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Anterior-enriched filopodia create appearance of asymmetric membrane microdomains in polarizing C. elegans zygotes

The association of molecules within membrane microdomains is critical for the intracellular organization of cells. During polarization of the C. elegans zygote, both polarity proteins and actomyosin regulators associate within dynamic membrane-associated foci. Recently, a novel class of asymmetric membrane-associated structures was described that appeared to be enriched in phosphatidylinositol 4,5-bisphosphate (PIP2), suggesting that PIP2 domains could constitute signaling hubs to promote cell polarization and actin nucleation. Here, we probe the nature of these domains using a variety of membrane- and actin cortex-associated probes. These data demonstrate that these domains are filopodia, which are stimulated transiently during polarity establishment and accumulate in the zygote anterior. The resulting membrane protrusions create local membrane topology that quantitatively accounts for observed local increases in the fluorescence signal of membrane-associated molecules, suggesting molecules are not selectively enriched in these domains relative to bulk membrane and that the PIP2 pool as revealed by PHPLCδ1 simply reflects plasma membrane localization. Given the ubiquity of 3D membrane structures in cells, including filopodia, microvilli and membrane folds, similar caveats are likely to apply to analysis of membrane-associated molecules in a broad range of systems.

Topic: Genetics, Aging, and Longevity in Model Organisms
Subfield: Aging
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Dehydration-driven solvent exposure of hydrophobic surfaces as a driving force in peptide folding

Recent work has shown that the nature of hydration of pure hydrophobic surfaces changes with the length scale considered: water hydrogen-bonding networks adapt to small exposed hydrophobic species, hydrating or “wetting” them at relatively high densities, whereas larger hydrophobic areas are “dewetted” [Chandler D (2005), Nature 29:640–647]. Here we determine whether this effect is also present in peptides by examining the folding of a β-hairpin (the 14-residue amyloidogenic prion protein H1 peptide), using microsecond time-scale molecular dynamics simulations. Two simulation models are compared, one explicitly including the water molecules, which may thus adapt locally to peptide configurations, and the other using a popular continuum approximation, the generalized Born/surface area implicit solvent model. The results obtained show that, in explicit solvent, peptide conformers with high solvent-accessible hydrophobic surface area indeed also have low hydration density around hydrophobic residues, whereas a concomitant higher hydration density around hydrophilic residues is observed. This dewetting effect stabilizes the fully folded β-hairpin state found experimentally. In contrast, the implicit solvent model destabilizes the fully folded hairpin, tending to cluster hydrophobic residues regardless of the size of the exposed hydrophobic surface. Furthermore, the rate of the conformational transitions in the implicit solvent simulation is almost doubled with respect to that of the explicit solvent. The results suggest that dehydration-driven solvent exposure of hydrophobic surfaces may be a significant factor determining peptide conformational equilibria.

Topic: Protein Structure and Dynamics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences