jimnoneill/paper-to-field-training huggingface dataset:
Custom House Visual Study of Gorontalo City

this study aims at discussing the meaning of the motive and the form of the Dulohupa traditional house.The method used in this study was qualitative-descriptive approach as a process of collecting a number of actual data and to get a detailed description of the symbols in the Dulohupa traditional house.The results of this study show that the meaning of the symbol in the Dulohupa traditional house is in the form of a roof made of planks, a staircase consisting of two pieces, the front part is on the part of the door, the wooden pillars and the number of stairs.The roof of the Dulohupa traditional house is shaped like a saddle, which is a two-story triangle roof depicting the population of Gorontalo.The upper roof illustrates the Gorontalo people's belief in the Almighty God, while the lower roof describes the trust of the Gorontalo people in customs and culture.This study concludes that the Dulohupa traditional house has many meanings and symbols that need to be preserved, by knowing the meaning and motives that exist, it is expected that the Gorontalo people respect customs more.

Topic: Architectural and Urban Studies
Subfield: Conservation
Field: Arts and Humanities
Domain: Social Sciences
A polymorphism within a conserved β<sub>1</sub>-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure

Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the β 1 -adrenergic receptor (β 1 AR), a β-blocker target, as candidate pharmacogenomic loci. Transfected cells, genotyped human nonfailing and failing ventricles, and a clinical trial were used to ascertain phenotype and mechanism. In nonfailing and failing isolated ventricles, β 1 -Arg-389 had respective 2.8 ± 0.3- and 4.3 ± 2.1-fold greater agonist-promoted contractility vs. β 1 -Gly-389, defining enhanced physiologic coupling under relevant conditions of endogenous expression and HF. The β-blocker bucindolol was an inverse agonist in failing Arg, but not Gly, ventricles, without partial agonist activity at either receptor; carvedilol was a genotype-independent neutral antagonist. In transfected cells, bucindolol antagonized agonist-stimulated cAMP, with a greater absolute decrease observed for Arg-389 (435 ± 80 vs. 115 ± 23 fmol per well). Potential pathophysiologic correlates were assessed in a placebo-controlled trial of bucindolol in 1,040 HF patients. No outcome was associated with genotype in the placebo group, indicating little impact on the natural course of HF. However, the Arg-389 homozygotes treated with bucindolol had an age-, sex-, and race-adjusted 38% reduction in mortality ( P = 0.03) and 34% reduction in mortality or hospitalization ( P = 0.004) vs. placebo. In contrast, Gly-389 carriers had no clinical response to bucindolol compared with placebo. Those with Arg-389 and high baseline norepinephrine levels trended toward improved survival, but no advantage with this allele and exaggerated sympatholysis was identified. We conclude that β 1 AR-389 variation alters signaling in multiple models and affects the β-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome.

Topic: Receptor Mechanisms and Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CCDC 132754: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
LHD nbpwr_tot_temporal #114380.1 (analyzed)

Sum of NBI port-through powers tangentially injected beam (NBI#1, NBI#2, NBI#3) and perpendicularly injected beam (NBI#4, NBI#5).

Topic: Advanced Fluorescence Microscopy Techniques
Subfield: Biophysics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Sustained by First Nations: European newcomers' use of Indigenous plant foods in temperate North America

Indigenous Peoples of North America have collectively used approximately 1800 different native species of plants, algae, lichens and fungi as food. When European explorers, traders and settlers arrived on the continent, these native foods, often identified and offered by Indigenous hosts, gave them sustenance and in some cases saved them from starvation. Over the years, some of these species – particularly various types of berries, such as blueberries and cranberries (&lt;em&gt;Vaccinium &lt;/em&gt;spp.), wild raspberries and blackberries (&lt;em&gt;Rubus &lt;/em&gt;spp.), and wild strawberries (&lt;em&gt;Fragaria &lt;/em&gt;spp.), and various types of nuts (&lt;em&gt;Corylus &lt;/em&gt;spp., &lt;em&gt;Carya &lt;/em&gt;spp., &lt;em&gt;Juglans &lt;/em&gt;spp., &lt;em&gt;Pinus &lt;/em&gt;spp.), along with wild-rice (&lt;em&gt;Zizania &lt;/em&gt;spp.) and maple syrup (from &lt;em&gt;Acer saccharum&lt;/em&gt;) – became more widely adopted and remain in use to the present day. Some of these and some other species were used in plant breeding programs, as germplasm for hybridization programs, or to strengthen a crop's resistance to disease. At the same time, many nutritious Indigenous foods fell out of use among Indigenous Peoples themselves, and along with their lessened use came a loss of associated knowledge and cultural identity. Today, for a variety of reasons, from improving people's health and regaining their cultural heritage, to enhancing dietary diversity and enjoyment of diverse foods, some of the species that have dwindled in their use have been “rediscovered” by Indigenous and non-Indigenous Peoples, and indications are that their benefits to humanity will continue into the future.

Topic: Indigenous Studies and Ecology
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Peer Relations as a Function of Physical Attractiveness: The Eye of the Beholder or Behavioral Reality?

LANGLOIS, JUDITH H., and DOWNS, A. CHRIS. Peer Relations as a Function of Physical Attractiveness: The Eye of the Beholder or Behavioral Reality? CHILD DEVELOPMENT, 1979, 50, 409-418. The relation between physical attractiveness and behavior was examined by assessing whether behavioral differences exist between attractive and unattractive children. 64 3and 5-year-old boys and girls were selected as subjects on the basis of physical attractiveness. Same age and sex, attractive, unattractive, and mixed-attractiveness dyads were formed and were observed in a seminaturalistic play setting. A categorical observation system was used to record affiliative, aggressive, activity-, and object-directed play behaviors. A developmental pattern was found for aggression: no differences based on attractiveness were evident in 3-year-olds, but 5-year-old unattractive children aggressed against peers more often than did attractive children. Unattractive children were generally more active than attractive children. Few differences in affiliative behaviors were found between attractive and unattractive children.

Topic: Evolutionary Psychology and Human Behavior
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Innateness, evolution, and genetics of language.

Our goal in this article is to review a debate over the evolution of language and to suggest some keys to its resolution. We begin with a review of some of the theoretical and empirical evidence for the innateness of language that has caused renewed interest in the evolution of language. In a second section we review some prominent theories of the evolution of language, focusing on the controversy over whether language could have been adapted for some purpose. We argue that for evolutionary studies of language to advance, theorists must make more persuasive arguments for the purpose of language, and, furthermore, linguists must continue to develop a detailed theory of syntax. Finally, we suggest ways that behavioral and population genetics could help to inform studies of the evolution of language.

Topic: Language and cultural evolution
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Comparative study between cytological and histopathological analysis results of hemithyroidectomy in treatment of solitary thyroid nodule

Aim:The aim of this study was to compare the outcome results of cytological examination by fine-needle aspiration cytology to histopathological examination by hemithyroidectomy in patients with solitary thyroid nodule.Patients and methods:We prospectively reviewed 30 consecutive patients had primary hemithyroidectomy for management of solitary thyroid nodule, carried out over a year (from January 2017 to January 2018) at Assiut University Hospital Surgical Department.Results:There were 24 women and six men with a mean age 34.67 years (range, 19–70 years). Preoperative findings of fine-needle aspiration cytology of these were: 17 (56.7%) patients had colloid nodule, 10 (33.3%) follicular neoplasm, and three3 (10%) hyperplastic nodule. Biopsied lesions were found to be malignant on pathological evaluation in two (6.6%) patients with follicular neoplasm, hemithyroidectomy was adequate definitive treatment in 28 of 30 (93.3%) patients.Conclusion:In a review of the experience at Assiut University Hospital Surgical Department, hemithyroidectomy was the optimal initial and definitive surgical approach for most patients with benign and indeterminate cytology and had undergone thyroid surgery for suspicion of cancer.

Topic: Thyroid Cancer Diagnosis and Treatment
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
The Hopf ring for P (n)

We show that E(P (n) ), the E-homology of the Ω-spectrum for P (n), is an E free Hopf ring for E a complex oriented theory with In sent to 0. This covers the cases P (q)(P (n) ) and K(q)(P (n) ), q n. The generators of the Hopf ring are those necessary for the stable result. The motivation for this paper is to show that P (n) satis es all of the conditions for the machinery of unstable cohomology operations set up in [BJW95]. This can then be used to produce splittings analogous to those for BP done in [Wil75].

Topic: Bioactive Natural Diterpenoids Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Differential expression of DPYSL2 in cancer of the vulva.

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of dihydropyrimidinase-like 2, encoded by DPYSL2, in cancer of the vulva. DPYSL2 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Study of Anterior Cervical Discectomy With or Without Fusion

Objectives : To retrospectively study and compare the clinical outcome of the patients undergoing anterior cervical discectomy (ACD), anterior cervical discectomy with fusion (ACDF), or anterior cervical discectomy with fusion and instrumentation (ACDFI) for cervical spondylosis. Methods : A retrospective analysis of 80 patients with cervical spondylosis who had undergone anterior cervical discectomy with or without fusion according to our preoperative assessment, were undertaken. Clinical outcome and associated complications in each group were analyzed to determine the need and efficacy of each procedure in these patients. Results : ACD and ACDF group had almost similar results in terms of hospital stay, mean time for improvement and patient satisfaction. ACDFI group had more prolonged hospital stay, took longer time to recover and to return to maximum normal status because of their poorer preoperative neurological status. Conclusions : Fusion is not routinely required, but it is indicated in patients with multisegmental disease, instability, loss of cervical lordosis, hard disc and osteophytic bars. Keys to achieve desirable clinical results are proper patient selection and adequate surgical decompression. No single gold standard procedure exists for the treatment of patients with cervical spondylosis and the treatment strategies need to be tailored to match the specific changes present in a given patient.

Topic: Cervical and Thoracic Myelopathy
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Rurality as a predictor of perinatal mental health and well‐being in an Australian cohort

Abstract Objective Perinatal emotional well‐being is more than the presence or absence of depressive and anxiety disorders; it encompasses a wide range of factors that contribute to emotional well‐being. This study compares perinatal well‐being between women living in metropolitan and rural regions. Design Prospective, longitudinal cohort. Participants/setting Eight hundred and six women from Victoria and Western Australia recruited before 20 weeks of pregnancy and followed up to 12 months postpartum. Main outcome measures Rurality was assessed using the Modified Monash Model (MM Model) with 578 in metropolitan cities MM1, 185 in regional and large rural towns MM2‐MM3 and 43 in rural to remote MM4‐MM7. The Structured Clinical Interview for DSM‐IV (SCID‐IV) was administered at recruitment to assess depression, and symptoms of depression and anxiety were measured using the Edinburgh Post‐natal Depression Scale and the State and Trait Anxiety Scale, respectively. Other measures included stressful events, diet, exercise, partner support, parenting and sleep. Results The prevalence of depressive disorders did not differ across rurality. There was also no difference in breastfeeding cessation, exercise, sleep or partner support. Women living in rural communities and who also had depression reported significantly higher parenting stress than metropolitan women and lower access to parenting activities. Conclusions Our study suggests while many of the challenges of the perinatal period were shared between women in all areas, there were important differences in parenting stress and access to activities. Furthermore, these findings suggest that guidelines and interventions designed for perinatal mental health should consider rurality.

Topic: Maternal Mental Health During Pregnancy and Postpartum
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Characterization of the Substrate Specificity and Mechanism of Protein Arginine Methyltransferase 1

Protein arginine methyltransferases (PRMTs) posttranslationally modify protein arginine residues. Type I PRMTs catalyze the formation of monomethylarginine (MMA) and asymmetric dimethylarginine (ADMA) via methyl group transfer from S-adenosyl methionine onto protein arginine residues. Type II PRMTs generate MMA and symmetric dimethylarginine. PRMT-methylation affects many biological processes. Although PRMTs are vital to normal development and function, PRMT-methylation is also linked to cardiovascular disease, stroke, multiple sclerosis, and cancer. Thus far, nine human PRMT isoforms have been identified with orthologues present in yeast, plants, and fish. PRMT1 predominates, performing an estimated 85% of all protein arginine methylation in vivo. Yet, the substrate specificity and catalytic mechanism of PRMT1 remain poorly understood. Most PRMT1 substrates are methylated within repeating `RGG' and glycine-arginine rich motifs. However, PRMT1 also methylates a single arginine on histone-H4 that is not embedded in a glycine-arginine motif, indicating that PRMT1 protein substrates are not limited to proteins with `RGG' sequences. In order to determine if PRMT1 displays broader substrate selectivity, I first developed a continuous spectrophotometric assay to measure AdoMet-dependent methyltransferase activity. Using this assay and a focused peptide library based on a sequence derived from the in vivo PRMT1 substrate fibrillarin, we observed that PRMT1 demonstrates amino acid sequence selectivity in peptide and protein substrates. PRMT1 methylated eleven substrate motifs that went beyond the `RGG' and glycine-arginine rich paradigm, suggesting that the methyl arginine proteome may be larger and more diverse than previously thought. PRMT1 methylates multiple arginine residues within the same protein to form protein-associated MMA and ADMA. Interestingly, ADMA is the dominant biological product formed and is a predictor of mortality and cardiovascular disease. To understand why PRMT1 preferentially forms ADMA in vivo, we began to 1) probe the mechanism of ADMA formation and 2) examine the catalytic role of certain active site residues and their involvement in ADMA formation. We found that PRMT1 dissociatively methylated several peptide substrates and preferred to methylate mono-methylated substrates over their non-methylated counterparts. Methylation of a multiple arginine-containing substrate was systematic (not random), a phenomenon that may be important biologically. All in all, our data help explain how PRMT1 generates ADMA in vivo.

Topic: Cancer-related gene regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Bone Screw Manufacturing for Bone Reconstruction: An Application in Veterinary Orthopedics

Currently, there are few studies on lyophilized bovine bone as a biomaterial for the manufacture of bone reconstruction implants [4] [8] [9] and these are usually focused on their manufacture, sterilization or mechanical comparison with other materials. The implants manufactured in this biomaterial have a main advantage over implants made of other materials, osteoinduction and osteoconduction, which cause the complete regeneration of the implant, eliminating the need for a second surgery to remove them. The main objective of this research article was to design and implement a guide for the manufacturing of HA2.7 screw implants; this manufacturing line includes the steps of material preparation, machining, cleaning, packaging and sterilization. In order to verify each of these stages, cytotoxicity tests, analysis of implant textures, chemical analysis, dimensional analysis, reproducibility and repetitiveness analysis of the process, and surface roughness analysis were used until the implantation of the screw as a fixation of fasciae latae implants. The surgery is based on an extraarticular repair of the anterior cruciate ligament rupture in a dog, where the behaviour of the screw was observed as its osseointegration in time until the patient recovered.

Topic: Orthopaedic implants and arthroplasty
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Cover Crops: Potential and Prospects in Conservation Agriculture

This chapter provides a comprehensive overview of practices and paybacks using cover crops necessary for augmenting the productivity, profitability and feasibility of conservation agriculture (CA) systems. Cover crops have the potential to produce long term tangible benefits by breaking up compacted layers in the soil, reducing the need for overly-aggressive mechanical tillage resulting in better traffic conditions. Cover cropping may impact soil microbial functionality responsible for important soil ecosystem services. Living mulches are cover crops that co-exist with the cash crop during the growing season and continue its growth even after the cash crop's harvest. Companion cropping can be a good weed suppressing technique but research helps in determining how suitable it may be in specific circumstances. Intercropping involves growing of two or more crops simultaneously in alternate rows having proper row arrangement, whereas in mixed cropping row arrangements are not maintained and different crop seeds are broadcasted randomly.

Topic: Agronomic Practices and Intercropping Systems
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Supplementary Materials and Methods from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks

&lt;p&gt;Description of Supplemental Materials and Methods&lt;/p&gt;

Topic: Molecular Biology Techniques and Applications
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
<p><strong>A new species of <em>Amboroppia </em>(Acari, Oribatida, Oppiidae) from the Peruvian Andes, with remarks on generic diagnosis</strong></p>

A new species of the neotropical genus Amboroppia (Oribatida, Oppiidae), A. andensis sp. nov. is described, based on adults collected from upper soil and leaf litter in primary mountain forest in the Andes, Central Peru. Additions to the generic diagnosis of Amboroppia are presented.

Topic: Study of Mite Species
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
MINIREVIEW—50th ANNIVERSARY SPECIAL ISSUE Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation s

The metabotropic glutamate (mGlu) receptors are a group of eight family C G protein–coupled receptors that are expressed throughout the central nervous system (CNS) and periphery. Within the CNS the different subtypes are found in neurons, both pre- and/or postsynaptically, where theymediatemodulatory roles and in glial cells. The mGlu receptor family provides attractive targets for numerous psychiatric and neurologic disorders, with the majority of discovery programs focused on targeting allosteric sites, with allosteric ligands now available for all mGlu receptor subtypes. However, the development of allosteric ligands remains challenging. Biased modulation, probe dependence, and molec-ular switches all contribute to the complex molecular pharmacol-ogy exhibited by mGlu receptor allosteric ligands. In recent years we have made significant progress in our understanding of this molecular complexity coupled with an increased understanding of the structural basis of mGlu allosteric modulation.

Topic: Neuroscience and Neuropharmacology Research
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Biodistribution of OVA antigen in vivo after injection of different formulation of adjuvants.

&lt;p&gt;C57BL/6J mice were administered Alexa647-labeled OVA (10 μg) or the indicated adjuvant formulations via the tail base. For combination, Alexa647-OVA (10 μg), DOTAP (100 μg), D35 (10 μg), and Alhydrogel (40 μg) in the Glu/PBS buffer were used. The fluorescence intensity of Alexa647 was measured every 1–2 days. (a) Representative image of Alexa647-labeled OVA detection using the VISQUE&lt;sup&gt;®&lt;/sup&gt; InVivo imager. The arrow indicates the signal at the injection site, and the arrowhead indicates the signal observed in the draining lymph node. DOTAP containing formulations were examined; (b)(d) None(Glu/PBS buffer only), OVA, OVA+Alhydrogel, OVA+D35. DOTAP containing formulations were examined; (c)(e) OVA+Alhydrogel+DOTAP+D35, OVA+DOTAP+D35, OVA+alhydrogel+DOTAP, OVA+DOTAP, OVA, None. The fluorescent intensities at the injection site (b)(c) and inguinal lymph node (d)(e) were measured using the VISQUE&lt;sup&gt;®&lt;/sup&gt; InVivo imager.&lt;/p&gt;

Topic: Advances in Cucurbitaceae Research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences