jimnoneill/paper-to-field-training huggingface dataset:
Symptom Burden’s Associated Factors among Hemodialysis Patients

Many patients with chronic kidney disease undergoing hemodialysis (CKD-HD) had a high symptom burden, which can worsen their health conditions and quality of life. The known factors associated to symptom burden were age, gender, hemodialysis (HD) session duration, post dialysis recovery time, hemoglobin level, nutrition status, physical activity, depression level and social support. The aim of this study was to analyze the most dominant factor associated to symptom burden among CKD-HD patients. Using a cross-sectional design, a convenience sample of eighty-five respondents were recruited from HD unit at Adventist Bandung Hospital, who underwent HD &gt; 3 months, HD frequency 2-3 times a week, aged ≥ 18 years, able to communicate and speak Indonesian. Data were retrieved via seven self-reported questionnaires and health records, and the symptom burden was assessed using the validated Indonesian version of the CKD-Symptom Burden Index. The data was analysed with Spearman correlation test, Chi square test, and multivariate logistic regression. Based on quartile category, most of the respondents (50.6%) had a high symptom burden (33.56±12.23). The factors significantly associated to symptom burden were age (p=0.015), post-dialysis recovery time (p=0.007) and depression level (p=0.000). In the final model, duration of HD session (OR=5.27, 95% CI 1.50-18.49) and depression level (OR=8.84, 95% CI 2.57-30.36) were the factors associated to high symptom burden. Depression level was the most dominant factor associated to high symptom burden. CKD-HD patients with depression are more at risk of experiencing a high symptom burden. Thus, symptom management may consider to modify depression level factor by screening for depression, providing assistance and nursing interventions, or developing depression-related interventions to reduce symptom burden in CKD-HD patients.

Topic: Dialysis and Renal Disease Management
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Terbium Luminescence from Complexes of Angiotensin II, Small Peptides, and Amino Acids

Lanthanide ions have been successfully used as luminescent probes in several biological systems. The terbium (Tb) luminescence is greatly enhanced in Tb(III)-protein systems by non-radiative energy transfer from aromatic chromophores to bound Tb3+ ions. In this study, the luminescent properties of terbium have been used to monitor the metal-peptide interactions of angiotensin II, a linear octopeptide hormone (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). The terbium luminescence was enhanced when the metal-complex was excited at either 259 nm or 280 nm (Phe and Tyr absorption bands, respectively). The results from a series of experiments with amino acids and small peptides show that the terbium luminescence from the Tb-Ang II complex is about the same as observed for a Tb-Phe complex when excited at 259 nm, but only 34% of the value of a Tb-Tyr complex excited at 280 nm. These results confirm the structural model of angiotensin II and show that the low enhancement of the terbium luminescence in peptide and amino acid complexes is due to weak binding and not poor energy transfer.

Topic: Protein Hydrolysis and Bioactive Peptides
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Sodium Hypochlorite Accidentally Extruded Beyond the Apical Foramen

Sodium hypochlorite (NaOCl) is routinely used as an endodontic irrigant to clean and disinfect the root canal system. Although it is generally believed safety, the tissue toxicity of NaOCl cannot be ignored. This report describes two cases of accidental extrusion of sodium hypochlorite solution into the periradicular tissues during root canal instrumentation. The literatures were reviewed to explore possible etiologies and possible complications. Diagnostic criteria for sodium hypochlorite accidents and strategies to mitigate the risk are also suggested.

Topic: Endodontics and Root Canal Treatments
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Long non‐coding <scp>RNA MALAT</scp>1 mediates hypoxia‐induced pro‐survival autophagy of endometrial stromal cells in endometriosis

Abstract Endometriosis is a common gynecological disease characterized by diminished apoptosis, sustained ectopic survival of dysfunctional endometrial cells. Hypoxia has been implicated as a crucial microenvironmental factor that contributes to endometriosis. It has been reported that long non‐coding RNA MALAT 1 (lnc RNA ‐ MALAT 1) highly expressed in endometriosis and up‐regulated by hypoxia. Hypoxia may also induce autophagy, which might act as cell protective mechanism. However, the relationship between lnc RNA ‐ MALAT 1 and autophagy under hypoxia conditions in endometriosis remains unknown. In the present study, we found that both lnc RNA ‐ MALAT 1 and autophagy level were up‐regulated in ectopic endometrium from patients with endometriosis, and its expression level correlates positively with that of hypoxia‐inducible factor‐1α ( HIF ‐1α). In cultured human endometrial stromal cells, both lnc RNA ‐ MALAT 1 and autophagy were induced by hypoxia in a time‐dependent manner and lnc RNA ‐ MALAT 1 up‐regulation was dependent on HIF ‐1α signalling. Our analyses also show that knockdown of lnc RNA ‐ MALAT 1 suppressed hypoxia induced autophagy. Furthermore, inhibiting autophagy with specific inhibitor 3‐Methyladenine (3‐ MA ) and Beclin1 si RNA enhanced apoptosis of human endometrial stromal cells under hypoxia condition. Collectively, our findings identify that lnc RNA ‐ MALAT 1 mediates hypoxia‐induced pro‐survival autophagy of endometrial stromal cells in endometriosis.

Topic: Endometriosis Research and Treatment
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Chromatin Morphology in Human Germinal Vesicle Oocytes and Their Competence to Mature in Stimulated Cycles

The search for simple morphological predictors of oocyte quality is an important task for assisted reproduction technologies (ARTs). One such predictor may be the morphology of the oocyte nucleus, called the germinal vesicle (GV), including the level of chromatin aggregation around the atypical nucleolus (ANu)—a peculiar nuclear organelle, formerly referred to as the nucleolus-like body. A prospective cohort study allowed distinguishing three classes of GV oocytes among 135 oocytes retrieved from 64 patients: with a non-surrounded ANu and rare chromatin blocks in the nucleoplasm (Class A), with a complete peri-ANu heterochromatic rim assembling all chromatin (Class C), and intermediate variants (Class B). Comparison of the chromatin state and the ability of oocytes to complete meiosis allowed us to conclude that Class B and C oocytes are more capable of resuming meiosis in vitro and completing the first meiotic division, while Class A oocytes can resume maturation but often stop their development either at metaphase I (MI arrest) or before the onset of GV breakdown (GVBD arrest). In addition, oocytes with a low chromatin condensation demonstrated a high level of aneuploidy during the resumption of meiosis. Considering that the degree of chromatin condensation/compaction can be determined in vivo under a light microscope, this characteristic of the GV can be considered a promising criterion for selecting the best-quality GV oocytes in IVM rescue programs.

Topic: Reproductive Biology and Fertility
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Study on Interaction between ctDNA and Ionic Surfactants by Resonance Rayleigh Scattering Method

The interaction between ctDNA and ionic surfactant were studied by Resonance Rayleigh Scattering (RRS).The re- sults indicated that cationic surfactant accumulate on the face of ctDNA by static or hydrophobic action,leading to the enhancement of ctDNA's RRS;anionic surfactant could cooperate with the interaction of acridine orange(AO) and ctDNA,leading to the enhancement of AO-ctDNA's RRS.

Topic: DNA and Nucleic Acid Chemistry
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A brief overview and an experimental evaluation of data confidentiality measures on the cloud

Due to the many advantages offered by the cloud computing paradigm, it is fast becoming an enabling technology for many organizations, and even individual users. Flexibility and availability are two of the most important features that promote the wide spread adoption of this technology. In cloud-based data storage scenarios, where the data is controlled by a third party (i.e. the cloud service provider), the data owner usually does not have full control of its data at all stages. Consequently, this poses a prime security threat, and a major challenge is the development of a secure protocol for data storage, sharing, and retrieval. In recent years, a number of research works have targeted this problem. In this paper, we discuss some of the major approaches for secure data sharing in the cloud computing environment. The goal is to provide a concise survey of existing solutions, discuss their benefits, and point out any shortcomings for future research. Specifically, we focus on the use of encryption schemes, and provide a comparative study of the major schemes, through implementation of some representative frameworks.

Topic: Cryptography and Data Security
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
507 Molecular Dynamics Simulation of Near-Threshold Fatigue Crack Propagation Behavior Using Linear-Elastic and HRR Singular Stress Fields

A molecular dynamics simulation of near-threshold fatigue crack propagation was conducted. To take the effect of plasticity around the region of analysis into account, the HRR displacement was given on the boundary of region. It was found that crack propagated more easily, when the HRR field was given than when the linear-elastic field was given. The retarding effect of grain boundary was also demonstrated.

Topic: Fatigue and fracture mechanics
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Consistency of circulating fluidized bed experimental data

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConsistency of circulating fluidized bed experimental dataS. Ouyang and O. E. PotterCite this: Ind. Eng. Chem. Res. 1993, 32, 6, 1041–1045Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ie00018a008https://doi.org/10.1021/ie00018a008research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Granular flow and fluidized beds
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
The class of 2-dimensional neat reducts is not elementary

$SC$, $CA$, $QA$ and $QEA$ stand for the classes of Pinter's substitution algebras, Tarski's cylindric algebras, Halmos' quasipolyadic algebras and Halmos' quasipolyadic algebras with equality, respectively. Generalizing a result of Andréka and Németi on

Topic: Algebraic structures and combinatorial models
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
A Schur Method for Computing Coprime Factorizations with Inner Denominators and Applications in Model Reduction

The paper presents a numerically reliable algorithm for computing minimal order rational coprime factorizations with inner denominators of transfer-function matrices. The proposed algorithm constructs the inner denominator sequentially asd a product of first or second order elementary inner factors by using an efficient Schur form updating technique. The algorithm is generally applicable regardless the state-space representation of the given transfer-function matrix is minimal or not, or is stabilizable/detectable or not. The resulting factorization is in a particular form which is well suited to be further employed in coprime factors model reductions or for computing 2-norms of unstable transfer-function matrices.

Topic: Model Reduction and Neural Networks
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences
ChemInform Abstract: A Novel Fluoride Ion Mediated Olefination of Electron‐Deficient Aryl Ketones by Alkanesulfonyl Halides.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Sulfur-Based Synthesis Techniques
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Commentary Cruising along Microtubule Highways: How Membranes Move through the Secretory Pathway

influence secretion has long intrigued cell biologists. Significant insight has come from studies showing that MTs serve as highways along which transport intermediates travel between the ER and Golgi (9, 10, 21, 28, 32), making it tempting to conclude that MTs are essential for secretion. While the literature contains many additional reports supporting that view (for example 7, 31), it is also oddly replete with reports that secretion is unimpaired in cells depleted of MTs (for example 12, 18, 39, 41). Thus, although MTs are used for some steps in secretion, they may not always be required. To understand fully the role of MTs in secretion, it is therefore necessary to look beyond the question of whether secretion can occur when MTs are absent, but focus instead on how biosynthetic products are

Topic: Cellular transport and secretion
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Клінічний перебіг гострого міокардиту у хворих зі збереженою фракцією викиду лівого шлуночка

The aim – to investigate the dynamic changes of the structural and functional state of the heart and the persistence of cardiac rhythm disorders in patients with acute myocarditis with preserved left ventricular ejection fraction (LV EF) during 6 months of follow-up.Materials and methods. 54 patients with acute myocarditis and preserved LV EF (&gt; 40 %) of the left ventricle (LV) were screened. The examination was performed twice: in the first month from the debut of myocarditis and in 6 months of follow-up. Results and discussion. According to data obtained by CMR, in the 1st month from the disease onset, the early contrast on T1-weighted images and/or the high intensity of the signal on T2 images were detected in all patients, with their percentage being 66.6 % and 62.9 % respectively, and late enhancement was observed in 14.8 % of cases. After 6 months of observation, edema and myocardial hyperemia were detected only in 7.4 and 9.2 % of cases, and fibrotic changes were in 37.0 % of patients, while 59.2 % of patients had no pathological changes on CMR at all. The average number of affected by inflammatory changes LV segments in the 1st month was 2.33±0.23, and after 6 months it decreased to 1.43±0.17 segments (р&lt;0.01). The value of LV EF increased from 47.3±2.3 % in the 1st month to 56.2±2.5 % after 6 months (р&lt;0.05) of follow-up, and detection of non-sustained ventricular tachycardia (NSVT) episodes decreased from 20.4 % cases in the 1st month to 7.4 % of cases after 6 months. According to the results of the correlation analysis, a strong direct correlation was established between the number of LV segments involved in the inflammatory process in the 1st month from the myocarditis onset (r=0.81, р&lt;0.01) as also after 6 months (r=0.72; р&lt;0.01) and the presence of NSVT episodes, that was also confirmed by determining the exact Fisher criterion (p=0.019), statistically reliable correlations of the same direction were also established between the presence of NSVT episodes and fibrotic changes on cardiac MRI.Conclusions. For patients with acute myocarditis with a preserved LV EF, the absence of severe violations of the LV contractile function is characterized by a small amount of inflammatory lesions of myocardium. Clinically significant cardiac rhythm disorders, in particular episodes of non-sustained ventricular tachycardia, can be observed in these patients in the absence of significant violations of the structural and functional heart state and are associated with a greater number of LV segments affected by inflammatory and fibrotic changes.

Topic: Viral Infections and Immunology Research
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Cram Sessions: 01 Collective Effort exhibition, The Baltimore Museum of Art, March 3-28, 2004

Collective Effort is the first of a three-part series of exhibitions titled Cram Sessions and organized by BMA curator, Chris Gilbert. Cram Sessions used local emerging artists to engage in a dialog of social, political, and economic subjects.

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

Antimicrobial resistance is a dramatic global threat; however, the slow progress of new antibiotic development has impeded the identification of viable alternative strategies. Natural antioxidant-based antibacterial approaches may provide potent therapeutic abilities to effectively block resistance microbes’ pathways. While essential oils (EOs) have been reported as antimicrobial agents, its application is still limited ascribed to its low solubility and stability characters; additionally, the related biomolecular mechanisms are not fully understood. Hence, the study aimed to develop a nano-gel natural preparation with multiple molecular mechanisms that could combat bacterial resistance in an acne vulgaris model. A nano-emulgel of thyme/clove EOs (NEG8) was designed, standardized, and its antimicrobial activity was screened in vitro and in vivo against genetically identified skin bacterial clinical isolates (Pseudomonas stutzeri, Enterococcus faecium and Bacillus thuringiensis). As per our findings, NEG8 exhibited bacteriostatic and potent biofilm inhibition activities. An in vivo model was also established using the commercially available therapeutic, adapalene in contra genetically identified microorganism. Improvement in rat behavior was reported for the first time and NEG8 abated the dermal contents/protein expression of IGF-1, TGF-β/collagen, Wnt/β-catenin, JAK2/STAT-3, NE, 5-HT, and the inflammatory markers; p(Ser536) NF-κBp65, TLR-2, and IL-6. Moreover, the level of dopamine, protective anti-inflammatory cytokine, IL-10 and PPAR-γ protein were enhanced, also the skin histological structures were improved. Thus, NEG8 could be a future potential topical clinical alternate to synthetic agents, with dual merit mechanism as bacteriostatic antibiotic action and non-antibiotic microbial pathway inhibitor.

Topic: Dermatology and Skin Diseases
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
International Order in Non-Nuclear World

Basing on the analysis of nuclear weapons’ functions in the contemporary international system, the author asks the question: whether there a demand for these features will persist, and if yes, who and how will perform these features? That is the main task that occurs when an attempt is made to analyze the peculiarities of international order in a post-apocalyptic world.

Topic: Nuclear Issues and Defense
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
An acetonic extract of Nicotiana tabacum leafs against pseudococcinide insects as pests on coffee shrubs in horticulture

Insects of the pseudococcinean subfamily are pests of numerous useful and ornamental plants. In the greenhouse of an educational and scientific horticulture holding, young 20cm-sized Coffea arabica shrubs were parasitized with mealybugs belonging to the genus Planococcus. The infestation was easily detectable by white, cottonwool-like colonies at the bottom of the leafs and the shoot, additionally the plants looked viscid round the colonies caused by secretions of the mealybugs, what in turn often favoured secondary infestations by mould. The infestation symptomatics were documented photographically.

Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
A case of maxillary gingival metastasis from lung cancer, the first symptom of which occurred in an oral cavity

今回われわれは,上顎歯肉に初発症状を認めた肺原発上顎歯肉転移癌を経験したためその治療経過の概要に文献的考察を加えて報告する。患者は80歳男性,初診時右側上顎歯肉に,直径18mm弾性軟の腫瘤を認めた。生検の結果,大細胞癌と診断された。歯肉原発の可能性が低く,全身精査を実施したところ,左側上肺野,胃,脳に腫瘍性病変を認め,肺原発多発転移癌の診断を得た。上顎歯肉転移癌は生検後急速に増大したため,S-1を併用した同時化学放射線療法を実施し,照射量合計38.4Gyで終了した。これらの放射線治療によって上顎歯肉転移癌の縮小を認めた。治療後,脳梗塞を発症し死の転帰となったが,死の直前まで腫瘍の増大もなく,経口摂取の継続が可能であった。根治治療の適応がない肺原発歯肉転移癌に対する,姑息的同時化学放射線療法は,患者のQOL維持に有効な治療法の1つであると思われた。

Topic: Cancer Diagnosis and Treatment
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Review on DNA Cryptography

Cryptography is the science that secures data and communication over the network by applying mathematics and logic to design strong encryption methods. In the modern era of e-business and e-commerce the protection of confidentiality, integrity and availability (CIA triad) of stored information as well as of transmitted data is very crucial. Deoxyribonucleic acid (DNA) is a genetic molecule consisting of two linked strands that wind around each other to form a double helical structure. The backbone of each strand is made of alternating deoxyribose sugar and phosphate groups. To each sugar one of four bases are attached i.e., adenine (A), cytosine (C), guanine (G) and thymine (T). DNA molecules, having the capacity to store, process and transmit information, inspires the idea of DNA cryptography. It is the rapid emerging unconventional techniques which combines the chemical characteristics of biological DNA sequences with classical cryptography to ensure non-vulnerable transmission of data. This innovative method is based on the notion of DNA computing. The methodologies of DNA cryptography are not coded mathematically; thus, it could be too secure to be cracked easily.

Topic: DNA and Biological Computing
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences