jimnoneill/paper-to-field-training huggingface dataset:
57 InDel markers for spotted longbarbel catfish, Hemibagrus guttatus developed by whole genome resequencing

<title>Abstract</title> Spotted longbarbel catfish,<italic> Hemibagrus guttatus</italic> (Lacepède, 1803), is benthic freshwater fish, mainly distributed in southern China, Laos, Thai, and Viet Nam. The wild population of <italic>H. guttatus</italic> is continuously decreasing, making it essential to protect this valuable fish resources. Understanding the genetic diversity and population structure of <italic>H. guttatus</italic> is critical to its protection. In the study, we therefore developed 57 InDel markers for <italic>H. guttatus</italic> by whole genome resequencing. The observed heterozygosity and expected heterozygosity ranged from 0.3333 to 0.5833 and 0.2778 to 0.5000, respectively. The value of polymorphism information content was between 0.2692 and 0.3750. One locus significantly deviated from the Hardy-Weinberg equilibrium (<italic>p</italic>&lt;0.05). These InDel markers are of great value for genetic diversity and conservation of <italic>H. guttatus</italic>.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Light Stimulates a Transducin-Independent Increase of Cytoplasmic Ca<sup>2+</sup>and Suppression of Current in Cones from the Zebrafish Mutant<i>nof</i>

Transducins couple visual pigments to cGMP hydrolysis, the only recognized phototransduction pathway in vertebrate photoreceptors. Here we describe a zebrafish mutant, no optokinetic response f(w21) (nof), with a nonsense mutation in the gene encoding the alpha subunit of cone transducin. Retinal morphology and levels of phototransduction enzymes are normal in nof retinas, but cone transducin is undetectable. Dark current in nof cones is also normal, but it is insensitive to moderate intensity light. The nof cones do respond, however, to bright light. These responses are produced by a light-stimulated, but transducin-independent, release of Ca2+ into the cone cytoplasm. Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm.

Topic: Retinal Development and Disorders
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Impact of process and outcome quality on intention for continued use of voice assistants

Purpose This paper aims to understand how the perceived usefulness of voice assistants (VAs) is affected by the perceived quality of the process (interaction) and the outcome (information). The authors also aim to determine the extent to which the perceived usefulness of VAs improves the perceived privacy associated with their use and increases users’ intention to continue using them. Consumer technology innovativeness is included as a personal trait moderator, to compare the results between tech and nontech innovators. For this purpose, the authors use the framework of the uses and gratifications theory (U&amp;GT). Design/methodology/approach A survey of 467 VA users was conducted and structural equation modeling was used to analyze the data. Findings The authors identify two main determinants of the perceived usefulness of VAs that influence users’ intention to continue using this technology, process quality and outcome quality. These two factors influence the continued use of VAs in different ways depending on the technology innovativeness of the consumers. The results show that tech innovators are oriented toward the interactive experience, and therefore, mainly value the process quality. In addition, nontech innovators are oriented toward a satisfactory response from VAs, and therefore, primarily value the outcome quality. In addition, the positive effect of perceived usefulness on perceived privacy is higher for tech innovators. Originality/value This study enhances the literature on the perceived usefulness of VAs within the framework of U&amp;GT. It identifies two antecedents (process quality and outcome quality) of perceived usefulness and observes significant differences based on technological innovativeness.

Topic: Technology Adoption and User Behaviour
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Reassessing Twitter’s Agenda-Building Power

This study examined the relationship between elite news media agendas and campaign agendas during the 2016 presidential primary season. Computer-assisted content analysis was used to assess issue emphasis within Twitter feeds of U.S. presidential primary candidates and their campaigns as well as the nation’s top newspapers. The relationship between the overall Twitter agenda and that of newspapers, as well as the influence of front-runners Clinton, Cruz, Sanders, and Trump, was investigated using time series analysis. Aggregate and candidate-specific findings reveal some reciprocal relationships, but overall greater influence of newspapers on the Twitter agenda was detected. Findings suggest that Twitter has the potential to break free from and influence traditional media gatekeeping.

Topic: Social Media and Politics
Subfield: Communication
Field: Social Sciences
Domain: Social Sciences
Metals, Metalloids and Toxicity in Date Palms: Potential Environmental Impact

This paper summarizes our studies on metal and metalloid uptake by the date palm, Phoenix dactylifera L., a tree of considerable importance in arid regions. The typical concentrations of 17 elements in the date palm are summarized and compared with existing data in the scientific literature. The role and toxicity of these elements are considered. Issues encountered by us during sample collection, pre-treatment and chemical analysis are described. Future studies are suggested.

Topic: Heavy metals in environment
Subfield: Pollution
Field: Environmental Science
Domain: Physical Sciences
[Respiratory hypoxia as a heart failure complication in patients with acquired heart defects operated on with artificial circulation and its treatment by artificial pulmonary ventilation with positive expiratory pressure].

The pulmonary gas exchange was studied in 148 patients with prosthesis of the cardiac valves during progressing cardiac insufficiency. It was established that with the increase of cardiac insufficiency respiratory disorders also increase, mainly at the expense of the increase of the intrapulmonary arterio-venous shunting of the blood. The use of artificial lung ventilation with positive expiratory pressure in the post-operative period decreases intrapulmonary shunting, thus increasing the partial pressure and oxygen saturation of the arterial blood, and does not exert depressing action on the cardiac activity.

Topic: Respiratory Support and Mechanisms
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Authenticated encryption scheme with (t, n) shared verification

A new authenticated encryption scheme with (t, n) shared verification based on discrete logarithms is proposed. In the scheme any ciphertext of signature for a message is addressed to a specified group of verifiers in such a way that the ability to decrypt the ciphertext of signature is regulated by the adopted (t, n) threshold scheme. That is, any t out of n verifiers in the group share the responsibility (or authority) for message recovery. The proposed scheme preserves the merits inherent in the signature scheme with message recovery and the (t, n) shared verification scheme. As compared to Harn&apos;s (t, n) shared verification scheme and its further modifications, the proposed scheme has the following advantages: it requires smaller bandwidth and achieves more secrecy of data transmission; it is more efficient for signature verification.

Topic: Cryptography and Data Security
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Comparative precautionary saving under higher-order risk and recursive utility

Measuring and comparing the precautionary saving motive rest almost exclusively on the expected utility framework, and only focus on income risk or coefficients of the Arrow–Pratt type. We generalize the standard approach by characterizing comparative precautionary saving under recursive utility for increases in income risk and increases in risk on the saving return, including higher-order risk effects. We express the comparisons in terms of precautionary premia. In addition, we define a new class of preference coefficients, and derive the associated conditions to predict a stronger precautionary motive. The coefficients provide a detailed picture of the preferences sustaining precautionary saving and could be useful in applications.

Topic: Decision-Making and Behavioral Economics
Subfield: General Decision Sciences
Field: Decision Sciences
Domain: Social Sciences
Response of equine monocytes to lipopolysaccharide from enteric and non-enteric bacteria: efficacy and receptor specificity

Endotoxin (lipopolysaccharide, LPS) activates inflammatory cells by interacting with a cellular receptor complex consisting of cluster differentiation antigen 14 (CD14), Toll-like receptor 4 (TLR4) and MD-2. LPS antagonists are structurally atypical LPS compounds that do not activate inflammatory cells and in fact inhibit cellular activation by endotoxin. LPS antagonists may be of therapeutic value and offer a tool for investigation of ligand-receptor interactions and species-specific differences in the response to different LPS compounds. This report describes the results of an investigation of the biological activities of three structurally atypical LPS compounds in equine and human cells. LPS from Rhodobacter sphaeroides (RsLPS), Rhizobium galegae (R. galegae) and Rhizobium Sin-1 (R. Sin-1) stimulated tumor necrosis factor ? (TNF?) production in equine monocytes while they inhibited the response to enteric LPS in a human monocyte cell line, Mono Mac 6. Using transfection experiments, it was determined that RsLPS stimulated nuclear factor ?B (NF-?B) activation in equine cells but not in human cells, and that stimulation of equine cells occurred independent of CD14. It was further determined that the TLR4/MD-2 complex determined the equine-specific response to RsLPS. Using transfection experiments and binding assays, it was determined that LPS from R. galegae and R. Sin-1 activated equine cells via CD14, TLR4 and MD-2 and that these compounds competed with enteric LPS for binding to equine monocytes. Contrary to their effect on TNF? production, LPS from R. galegae and R. Sin-1 also stimulated NF-?B activation in cells expressing human receptor proteins, thereby putting into question a competitive mechanism of antagonism for these compounds. In an additional study, binding assays were used to estimate the number of binding sites for LPS on Mono Mac 6 cells and the affinity of LPS binding to these cells. Comparison to cell stimulation assays suggested the presence of spare receptors. Competition experiments further suggested an allosteric effect of certain LPS compounds on LPS binding to Mono Mac 6 cells.

Topic: Immune Response and Inflammation
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Effect of Weld Defects on the Fatigue Strength of Ultra High-strength Steels

Enhancing the lightweight potential of mobile steel structures by applying high-strength steels and reducing sheet thicknesses leads to a significant increase of energy effectiveness and a reduction of noxious emissions during operation. However, due to this increase of yield and tensile strength, fracture toughness decreases and notch sensitivity rises. Hence, the local weld geometry becomes more important, especially in case of ultra high-strength steels. This paper deals with the detection and assessment of common geometric weld defects, such as undercuts, and their effect on the fatigue strength of ultra high-strength steel joints. For this purpose, butt joint specimens are welded incorporating ultra high-strength steel as base material. All specimens are judged by visual testing and the detected weld defects undergo an additional surface topography measurement prior to fatigue testing. First, an image processing based Matlab©-Routine is built up to evaluate the local geometrical properties of the weld toe including undercuts. Second, a numerical model of the actual weld geometry is generated. This is utilized to perform numerical analyses in order to compute the actual stress concentration factors as well as fatigue parameters in terms of notch stresses. The experimental work covers fatigue tests of undercut-imperfected and defect-free specimens in order to contribute to the effect of such defects on fatigue life. Finally, an enhanced fatigue assessment of welds with undercuts and high-quality joints is performed based on numerical investigations and validated by experimental results.

Topic: Fatigue and fracture mechanics
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
New Developments in Sentinel Lymph Node Biopsy Procedure in Localized Oral Cancer

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal

Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Progressive lossless compression of medical images

This paper describes a lossless compression method for medical im-ages that produces an embedded bit-stream, allowing progressive lossy-to-lossless decoding with L-infinity oriented rate-distortion. The experimental results show that the proposed technique produces better average lossless compression results than several other com-pression methods, including JPEG2000, JPEG-LS and JBIG, in a publicly available medical image database containing images from several modalities. Index Terms — Medical image compression, lossless image coding, progressive transmission, finite-context models. 1.

Topic: Advanced Data Compression Techniques
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Interpreter ideology

Abstract This study investigates empirically the way in which interpreter ideology is manifested in the evaluative language of the World Economic Forum’s Annual Meeting in China in 2016 (English–Chinese language pair). Methodologically, van Dijk’s Ideological Square and Martin and White’s Appraisal framework have been operationalised for the analysis of positive or negative evaluative language in ‘us’ vs ‘them’ discourses. The results reveal an overall positive-‘us’ and negative-‘them’ pattern in the interpreter’s ideological positioning. This is manifested in three ways: (i) negative, pejorative, and sensitive discourses about China are self-censored; (ii) positivity is accentuated and negativity is neutralised in China-related discourses, and (iii) negative tones in the discourses of other countries are amplified. The speaker discourse is ‘edited’ when interpreter ideology is at work during the simultaneous interpreting process. However, the linguistic patterns can provide only partial indications of the possible relationship between interpreter ideology and cognitive operations.

Topic: Interpreting and Communication in Healthcare
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
A New Measure of Monetary Shocks: Derivation and Implications

This paper develops a measure of U.S. monetary policy shocks for the period 1969–1996 that is relatively free of endogenous and anticipatory movements. Quantitative and narrative records are used to infer the Federal Reserve’s intentions for the federal funds rate around FOMC meetings. This series is regressed on the Federal Reserve’s internal forecasts to derive a measure free of systematic responses to information about future developments. Estimates using the new measure indicate that policy has large, relatively rapid, and statistically significant effects on both output and inflation. The effects are substantially stronger and quicker than those obtained using conventional indicators. (JEL E52, E58, E32, E31) The accuracy of estimates of the effects of monetary policy depends crucially on the validity of the measure of monetary policy that is used. Use of an inappropriate measure may obscure a relationship between monetary policy and other economic variables that actually exists, or create the appearance of a relationship where there is no true causal link. For this reason, this paper derives a new measure of monetary policy shocks that is free from some key deficiencies of previous measures. The new measure yields estimates of the impact of monetary policy on both real and nominal variables that are stronger and faster than those obtained using conventional indicators. Conventional measures of monetary policy have some obvious flaws. One is the likelihood of endogenous movements. The money supply, for example, tends to rise in good times because the money multiplier rises. Even the federal funds rate, which has become the standard indicator of monetary actions in studies of the effects of monetary policy, moves a great deal

Topic: Monetary Policy and Economic Impact
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Culture, Context, Violence: Eurasia in Comparative Perspective

The links between culture and violence are as old as theorising about the concepts themselves.1 From Thucydides to Weber to Samuel Huntington, problems of social order and the cultural transformations produced by violent behaviour have been perennial subjects of concern. Despite this long tradition, political scientists have normally shied away from thinking systematically about their connections. Culture seems too slippery a concept to be easily grasped, and implying that there is a cultural dimension to large-scale organised violence — from riots to genocide to full-scale war — seems dangerously close to a kind of crude determinism: that some societies are simply fated to live in more violent ways than others because of their imponderable cultural proclivities. Even when writers have taken a slightly different tack, such as in Huntington's (1998, 2004) argument about the durability of social conflict along broad cultural cleavages, empirical analysis has usually shown the idea of some fundamental consonance between culture and conflict to be bunk (Fox, 2002; Henderson, 2004).KeywordsPolitical CultureComparative PerspectiveViolent EventMass ViolenceAssociational LifeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Topic: Political Conflict and Governance
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
<scp>BRAF</scp> internal deletions and resistance to <scp>BRAF</scp>/<scp>MEK</scp> inhibitor therapy

Summary BRAF and MEK inhibitors have improved clinical outcomes in advanced, BRAF V 600 ‐mutated melanomas. Acquired resistance occurs in most patients, with numerous and diverse drivers. We obtained pretreatment and progression biopsies from a patient who progressed on dabrafenib and trametinib. In addition to a preserved BRAF V 600E mutation, an internal deletion (rearrangement) of BRAF was observed in the progression sample. This deletion involved exons 2–8, which includes the Ras‐binding domain, and is analogous to previously documented BRAF fusions and splice variants known to reactivate RAS ‐ RAF ‐ MEK ‐ ERK signaling. In a large cohort of melanomas, 10 additional internal deletions were identified (0.4% of all melanomas; nine of which had concurrent BRAF mutations), as well as sporadically in other tumor types. Thus, we describe a novel mechanism of resistance to BRAF and MEK inhibition.

Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Leading The Witness: Pediatric Palliative Program Improvement Through Instructional Investigation

Background: Palliative Care consultation can often be limited primarily to the practice areas of those staffing the program. In Pediatrics, this is further complicated by the difficulties of prognostication in chronically-ill children and confusion surrounding the purpose of Palliative Care in a non-terminal but seriously ill child. Quality Improvement initiatives that are limited to directive interventions, such as consult triggers or structured educational offerings, can often be viewed as invasive or presumptuous by colleagues that see palliative practice as part of their own specialty. In these circumstances, we have found …

Topic: Childhood Cancer Survivors' Quality of Life
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Conceptual Approaches to Formation of Wood Industry Cluster in Russia

World experience shows the effectiveness of the creation of clusters in various industries. A lot of work and research domestic and foreign scholars and practitioners are dedicated to study and development of mechanisms of realization of industrial policy. The article analyzes the main indicators of the forest industry and forestry in Tomsk region in recent years, the basic provisions are revealed, Factors determining the development trends of the industry are analyzed. The authors identified the major systemic problems hindering the progressive development of forest sector in Tomsk region, including low level of development of periodic yield, the lack of transport and economically available forest resources, inadequate production structure and export of forest products, financial situation of enterprises of the sector, insufficient staffing, weak territorial cooperation of the enterprises and organizations. The article defines the objective conditions for creation of timber industry cluster in Tomsk region, goals, objectives and directions of sustainable development of the forest sector in Tomsk region on the basis of cluster approach are identified. Among the main areas that determine competitiveness of products and possibility of increasing the efficiency of forest management, the following issues are highlighted: development of deep processing of wood through the use of low-grade wood and wood waste, development of transport infrastructure in forests, improving human potential, expanding the range of manufactured timber enterprises in the cluster of products and implementation of joint projects. The conclusions can provide theoretical basis for further research in the field of economic security and development of timber processing complex and forestry. Obtained results can be used both by researchers in further research work to explore issues of cluster development of timber industry and regional authorities and business structures functioning in the sphere of forest industry.

Topic: Natural Resources and Economic Development
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences