jimnoneill/paper-to-field-training huggingface dataset:
Level and instability of day-to-day psychological well-being and risk for depression.

For 21 days, 123 undergraduates provided measures of their self-esteem, anxiety, causal uncertainty, perceived control over outcomes, and the three constructs comprising A. T. Beck's (1972) cognitive triad. Factor analyses of measures of the mean level and day-to-day instability of these constructs produced 2 factors, level of well-being and day-to-day instability of well-being. Participants also provided 4 measures of risk for depression over 2 1/2 months. For participants who were not at risk for depression, level of day-to-day well-being was negatively related to risk for depression, and this effect was not moderated by day-to-day instability. In contrast, for participants who were classified as at-risk for depression, day-to-day instability of well-being moderated the strength of the negative relationship between level of well-being and risk for depression. The relationship between level of well-being and depression was stronger for participants who were more unstable.

Topic: Psychological Well-being and Life Satisfaction
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Standardized Outcome Measures in Stroke Rehabilitation and Falls After Discharge: A Cohort Study

Introduction Individuals with stroke discharged from inpatient rehabilitation units (IRUs) are at increased risk for falls. In IRUs, standardized outcome measures (SOMs) have been used to predict falls, but the results have been mixed. Objective To examine the relationship between SOMs and the risk of falls in individuals with stroke within 6 months of discharge from an IRU. Design Prospective cohort study with 6‐month follow‐up. Setting IRU that was part of a large, urban academic medical center. Participants Individuals with stroke who underwent rehabilitation. Main Outcome Measures Self‐reported falls within 6 months of discharge. Results The study included 105 participants who were discharged to their homes after inpatient rehabilitation and who responded to a 6‐month follow‐up (57% response rate) phone call. Twenty‐nine participants (28%) reported falling. Significant odds ratios (ORs), adjusted for age, sex, and stroke severity, were found for the following measures: Berg Balance Scale (OR 0.95, 95% confidence interval [CI] 0.92‐0.99), Activity Measure for Post‐Acute Care basic mobility (OR 0.89, 95% CI 0.81‐0.97), Motricity Index (OR 0.96, 95% CI 0.94‐0.98), Functional Independence Measure mobility subscale (OR 0.89, 95% CI 0.80‐0.98), and Trunk Control Test (OR 0.97, 95% CI 0.95‐0.99). Areas under the curve ranged from .64 to .71. In samples of 82 to 90 patients who could complete the tests, gait speed, the Functional Reach Test, the 6‐minute Walk Test, and Timed Up and Go did not result in significant ORs. Conclusions At discharge, SOMs were associated with the odds of falls within 6 months. The multifactorial nature of falls will continue to make prediction challenging but SOMs can be helpful. Lower extremity strength deserves more attention as a risk factor.

Topic: Stroke Rehabilitation and Recovery
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
[Realgar nanometer suspension inducing apoptosis of Siha cell and its effect on expression of HPVE6/E7 oncogene].

Realgar nanometer suspension can inhibit the proliferation of human carcinoma cervical cell Siha line and induce the cell apoptosis. The mechanism may be related to the down-regulation of HPV16E6/E7 oncogene expression.

Topic: Cancer Research and Treatments
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Precariously balanced rocks and ground-motion maps for Southern California

Abstract Groups of precariously balanced rocks are effectively low-resolution strong-motion seismoscopes that have been operating on solid rock outcrops for thousands of years and, once the methodology has been developed, can provide important information about seismic risk. In one zone, near Victorville, only 30 km from the nearest point on the San Andreas fault, more than 50 precarious rocks have been documented. Widespread rock varnish suggests that many of these rocks have been in their current unstable positions for thousands of years. We have established the mechanical basis for rough estimates of the horizontal accelerations necessary to topple these rocks, using field observations and numerical and physical modeling. To verify that zones of precarious rocks do not occur near historic earthquakes, searches using binoculars were made along roads, with occasional foot surveys, near large earthquakes. Based on these reconnaissance searches, we conclude that no precarious rock zones are found within 15 km of zones of high-energy release of historic large earthquakes. To document the occurrence of precarious rocks in southern California, road surveys were carried out along major roads. Four zones of precarious rocks and seven other zones of somewhat less precarious rocks have been documented. Published probabilistic ground-motion maps for southern California are compared with the occurrence of zones of precarious and semi-precarious rocks. The results are encouraging and suggest that eventually, studies of precarious rocks will provide important constraints on the assumptions on which the maps are based. Results from studies of precarious rocks may eventually provide important information for siting and design of sensitive structures such as hospitals and power plants. Precarious rocks give a direct indication of past ground shaking, in contrast to the indirect inference provided by fault-trenching studies, which may be subject to uncertainties in the actual time history of slip due to the fault (e.g., fault creep, “slow” earthquakes, or unknown dynamic stress drop). It is concluded that precarious rocks warrant further study and quantitative analysis.

Topic: earthquake and tectonic studies
Subfield: Geophysics
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Man-houng Lin. China Upside Down: Currency, Society, and Ideologies, 1808–1856. Cambridge MA: Harvard University Asia Center, 2006. xxvi + 362 pp. ISBN 0-674-02268-8, $49.95.

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Topic: Chinese history and philosophy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Mechanism and Potential of Senolytics in Tumour Microenvironment

Senescent cells (SnCs) produce stress response and enter a state of proliferation arrest under the action of drug radiotherapy and chemotherapy, and secrete senescence related secretory phenotype (SASP), which can participate in the remodeling of tumor microenvironment (TME) through the secretion of inflammatory factors and cancer-promoting factors. The influence of cell senescence on tumors is complex, which has both tumor inhibitory and tumor promoting effects. This study shows that senescent cells are responsible for the tumor promotion mechanism. Senolytics appears as a drug that selectively clears senescent cells. It induces apoptosis by targeting the upregulated anti-apoptotic pathway in senescent cells (such as the BCL-2 family), thereby reducing the accumulation of senescent cells, inhibiting the negative effects of SASP, and improving the TME. Enhance the efficacy of anti-cancer therapy and explore the adverse effects of Senolytics in the TME, aiming to provide new ideas and strategies for future Senolytics therapy optimization and treatment of cancer.

Topic: Glycosylation and Glycoproteins Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Reverse Protonation Is the Key to General Acid−Base Catalysis in Enolase<sup>,</sup>

The pH dependence of enolase catalysis was studied to understand how enolase is able to utilize both general acid and general base catalysis in each direction of the reaction at near-neutral pHs. Wild-type enolase from yeast was assayed in the dehydration reaction (2-phospho-D-glycerate --> phosphoenolpyruvate + H(2)O) at different pHs. E211Q, a site-specific variant of enolase that catalyzes the exchange of the alpha-proton of 2-phospho-D-glycerate but not the complete dehydration, was assayed in a (1)H/(2)H exchange reaction at different pDs. Additionally, crystal structures of E211Q and E168Q were obtained at 2.0 and 1.8 A resolution, respectively. Analysis of the pH profile of k(cat)/K(Mg) for wild-type enolase yielded macroscopic pK(a) estimates of 7.4 +/- 0.3 and 9.0 +/- 0.3, while the results of the pD profile of the exchange reaction of E211Q led to a pK(a) estimate of 9.5 +/- 0.1. These values permit estimates of the four microscopic pK(a)s that describe the four relevant protonation states of the acid/base catalytic groups in the active site. The analysis indicates that the dehydration reaction is catalyzed by a small fraction of enzyme that is reverse-protonated (i.e., Lys345-NH(2), Glu211-COOH), whereas the hydration reaction is catalyzed by a larger fraction of the enzyme that is typically protonated (i.e., Lys345-NH(3)(+), Glu211-COO(-)). These two forms of the enzyme coexist in a constant, pH-independent ratio. The structures of E211Q and E168Q both show virtually identical folds and active-site architectures (as compared to wild-type enolase) and thus provide additional support to the conclusions reported herein. Other enzymes that require both general acid and general base catalysis likely require reverse protonation of catalytic groups in one direction of the reaction.

Topic: S100 Proteins and Annexins
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Occurrence Download

A dataset containing 281 species occurrences available in GBIF matching the query: { "and" : [ "Country is Tunisia", "OccurrenceStatus is Present", "TaxonKey is Quercus L." ] } The dataset includes 281 records from 30 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0006512-250525065834625/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.

Topic: Food Security and Health in Diverse Populations
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
USE OF GEOGRAPHICAL INFORMATION SYSTEM AND WATER QUALITY INDEX TO ASSESS GROUNDWATER QUALITY IN AND AROUND RANIPET AREA, VELLORE DISTRICT, TAMILNADU

An attempt has been made to understand the ground water quality by using water quality index in and around Ranipet area of Vellore District. It is a technique of rating water quality, is an effective tool to assess spatial and temporal changes in ground water quality. Thirty five groundwater samples were collected from open and tube wells during the Monsoon and Post Monsoon season in the year 2012. This was done by subjecting the 35 groundwater samples collected to comprehensive physico-chemical analysis using standard methods of analysis. From the data obtained, the water quality index was calculated by adopting the method developed by Tiwari and Mishra. Water quality index rating was carried out to quantify overall ground water quality status of the area. For calculating the index, the following 9 parameters have been considered such as pH, Total Dissolved Solids, Total Hardness, Calcium, Magnesium, Sulphates, Chlorides, Fluorides, and Nitrates. The average values of water quality index of the samples were found in the value of 142.59 in monsoon season while it was 115.4 in post-monsoon season. The higher concentration of dissolved solids during post monsoon samples exhibits poor quality of water as compared to Monsoon season. It may be due to more seepage and movement of ground water during post-monsoon.

Topic: Water Quality and Pollution Assessment
Subfield: Water Science and Technology
Field: Environmental Science
Domain: Physical Sciences
Mitigation of Lps-induced Anxiety and Oxidative Stress Through Mitragynine: Targeting Tlr-4 and Mda Modulation

<title>Abstract</title> <bold>Introduction: </bold>Neuroinflammation marked by increased toll-like receptor (TLR)-4 expression contributes to the pathogenesis of anxiety disorders. Mitragynine, an indole alkaloid derived from the kratom plant (<italic>Mitragyna speciosa</italic> Korth), shows promise as a potential pharmacotherapeutic agent for anxiety due to its anti-inflammatory activity. However, the mechanism involved in its anxiolytic effect remains unclear. <bold>Aims:</bold> This study investigated the effects of mitragynine on anxiety-like behaviours, TLR4 expression and oxidative stress in the frontal cortex of rats treated with lipopolysaccharide (LPS). <bold>Methodology:</bold> Rats received a single 1 mg/kg LPS injection intraperitoneally (i.p.) to induce anxiety. Mitragynine was then administered at the doses of 1, 5 or 10 mg/kg body weight 1h post-LPS administration. Impact of mitragynine on anxiety was assessed using both open field test (OFT) and elevated plus maze (EPM). TLR4 expression was measured using western blot, while oxidative stress markers (MDA, GSH, GPx, CAT) were measured using protein assays. <bold>Results:</bold> Mitragynine ameliorated LPS-induced anxiety behaviours in the EPM. Mitragynine (5 and 10 mg/kg) reversed the effect of LPS on TLR4 expression in the rats’ brains. All doses of mitragynine reduced lipid peroxidation in the frontal cortex of LPS-treated rats. Conclusion: Mitragyninemitigates LPS-induced anxiety by alleviating lipid peroxidation in the frontal cortex.

Topic: Alkaloids: synthesis and pharmacology
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Reciprocal Tariff Reductions Under Asymmetric Bargaining Power

Abstract Increasing heterogeneity of participants that form the basis of WTO trade negotiations has raised concerns about unfair treatment of weak countries due to their lack of bargaining power. The WTO responds to these concerns by arguing that the institutional design with its specific rules such as the principle of reciprocity serves to reduce inequalities in bargaining power by giving smaller (weaker) countries more voice. A recent study has challenged this result for a particular type of reciprocity, namely the volume approach. Given the wide discretion of how reciprocal concessions are conducted, I give a more complete picture of how different kinds of reciprocity affect the bargaining outcome of asymmetric countries. It turns out that, while the volume approach amplifies the negative effects of power asymmetries, a tariff formula approach has the ability to reverse this effect. For low symmetries, the Swiss formula does the best job, whereas for larger power differences, a linear formula is best suited to reduce the impact of power asymmetries.

Topic: Global trade and economics
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Sub-surface petrochemistry, stratigraphy and hydrothermal alteration of the domes area, Olkaria geothermal field, Kenya

Wells OW-905A, OW-910 and OW-917 have been drilled in the Domes area of the Olkaria geothermal field. Wells OW-905A and OW-910 have been drilled inside the caldera while OW-917 has been drilled on the eastern margins of the caldera rim. The caldera rim is characterised by a ring of rhyolitic domes to the east, south and southwest margins. Plans are underway to expand production drilling to the east of the Domes field. This study presents an in-depth look at the variation in reservoir characteristics across the Domes field and to the east of the ring structure. The study also delineates magma differentiation processes involved in the evolution of the GOVC. Wells OW-905A and OW-910 cut across seven stratigraphic units namely basalt, trachybasalt, basaltic trachyandesite, trachyandesite, trachyte, rhyolite and tuff. Well OW-917 only cuts across trachyte and rhyolite. Intrusives cut by the wells include micro-granite, syenitic, trachytic and basaltic dykes. Well OW-910 has a high abundance of high-temperature alteration minerals, OW-905A has moderate abundance while OW-917 has low abundance of these minerals. Higher temperatures are observed at shallower depth in OW-910, at relatively greater depth in OW-905 and at greater depth in OW-917. High permeability is observed in wells OW-905A and OW-910. Well OW-917 shows poor permeability. Well OW-905A is located in a recharge zone, OW-910 in the up-flow zone close to the heat source and OW-917 in a down-flow zone. The main magma differentiation processes involved in generation of the basalt-trachyte suite are fractional crystallisation and magma mixing. Rhyolites have been generated through fractionation of trachytes and anatexis of syenites. The GOVC has had different episodes of eruptions. Its plumbing system consists of independent discrete magma chambers and conduits in which magma underwent modification before eruption.

Topic: Geochemistry and Geologic Mapping
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Creating a Sustainable E-Commerce Environment: The Impact of Product Configurator Interaction Design on Consumer Personalized Customization Experience

Promoting consumers’ willingness to pay is crucial to creating a sustainable e-commerce environment, and the interaction design of the product configurator plays a key role in this. In the present study, the product configurator, which is indispensable in online customization, is adopted as the research object to analyze the influence of interaction design on the customization experience of consumers. The pricing method (total product pricing, incomplete total product pricing, and individual module pricing) and navigation design pattern (tabs and dropdown menu with arrow buttons) are adopted as independent variables, while system usability, flexible navigation capability, perceived control, perceived enjoyment, complexity and task performance are taken as dependent variables. One hundred and eighty college students participated in this study. The results of the 3 × 2 two-factor experiment reveal that: (1) Different navigation design patterns will lead to significant differences in system usability, flexible navigation capability, and perceived control of the product configurator, and tabs are better than dropdown menu with arrow buttons in these aspects. (2) Different pricing methods will significantly affect the perceived control of users. Under individual module pricing and incomplete total product pricing, perceived control is higher. (3) Different combinations of pricing methods and navigation design patterns will affect users’ evaluation of flexible navigation capability and complexity, and under the individual module pricing and incomplete total product pricing methods, users think that tabs have a higher flexible navigation capability and lower complexity. However, under the total product pricing method, users are convinced that dropdown menu with arrow buttons has a higher flexible navigation capability and lower complexity. The research results are of great significance to both interface interaction design and online customization. Furthermore, the interaction design method of price presentation and navigation design of the product configurator is analyzed to determine the most appropriate interaction design principles, so as to enhance the user experience of online customization and provide constructive ideas from the design perspective for online customization.

Topic: Consumer Retail Behavior Studies
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
A Novel Serine/Threonine Protein Kinase Homologue of <i>Pseudomonas aeruginosa</i> Is Specifically Inducible within the Host Infection Site and Is Required for Full Virulence in Neutropenic Mice

ABSTRACT A genetic locus of Pseudomonas aeruginosa was identified that is highly and specifically inducible during infection of neutropenic mice. This locus, ppkA , encodes a protein that is highly homologous to eukaryote-type serine/threonine protein kinases. A ppkA null mutant strain shows reduced virulence in neutropenic mice compared to the wild type. Overexpression of the PpkA protein greatly inhibited the growth of Escherichia coli or P. aeruginosa . However, a single amino acid change at the catalytic site of the kinase domain eliminated the toxic effect of PpkA on bacterial cells, suggesting that the kinase domain of PpkA is functional within bacterial cells.

Topic: Antibiotic Resistance in Bacteria
Subfield: Molecular Medicine
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
ABSCISIC ACID BIOSYNTHESIS AND CATABOLISM

The level of abscisic acid ( ABA abscisic acid ) in any particular tissue in a plant is determined by the rate of biosynthesis and catabolism of the hormone. Therefore, identifying all the genes involved in the metabolism is essential for a complete understanding of how this hormone directs plant growth and development. To date, almost all the biosynthetic genes have been identified through the isolation of auxotrophic mutants. On the other hand, among several ABA catabolic pathways, current genomic approaches revealed that Arabidopsis CYP707A genes encode ABA 8′-hydroxylases, which catalyze the first committed step in the predominant ABA catabolic pathway. Identification of ABA metabolic genes has revealed that multiple metabolic steps are differentially regulated to fine-tune the ABA level at both transcriptional and post-transcriptional levels. Furthermore, recent ongoing studies have given new insights into the regulation and site of ABA metabolism in relation to its physiological roles.

Topic: Plant Stress Responses and Tolerance
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Multi-objective evolutionary product bundling

[EN] Product bundling is a strategy conducted by marketing decisionmakers\nto combine items or services for targeted sales in today¿s\ncompetitive business environment. Targeted sales can be in various\nforms, like increasing the likelihood of a purchase, promoting some\nproducts among a specific customer segment, or improving user experience.\nIn this study, we propose an evolutionary product bundle\ngeneration strategy that is based on the NSGA-II algorithm. The\nproposed approach is designed as a multi-objective optimization\nprocedure where the objectives are designed in terms of desired\nbundle feature distributions. The designed genetic algorithm is flexible\nand allows decision-makers to specify objectives such as price,\nseason, item similarity and association with bundle size constraints.\nIn the experiments,we showthat the evolutionary approach enables\nus to generate Pareto solutions compared to the initial population.

Topic: Service and Product Innovation
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences