jimnoneill/paper-to-field-training huggingface dataset:
Dapsone Associated Methemoglobinemia-----A Case of Blue Discoloration

Dapsone is among the medicine that belongs to sulfone groups and being used to treat leprosy and dermatitis. It inhibits the synthesis of dihydrofolic acid by competing with para-aminobenzoic acid. This is a case of a lady in her mid70&amp;apos;s known case of pyoderma gangrenosum recently started on dapsonepresented to ED with complaint of shortness of breath, discoloration of fingers for 4days. Patient had saturation of 88% room air. Relevant examination showed blue discoloration of the finger pulps. Arterial blood gas analysis showed oxygen saturation of 98%RA and PaO2 of 87mmHg, suggestive of positive saturation gap. She was treated with IV methylene blue on the impression of methemoglobinemia and her discoloration improved rapidly. An approach to hypoxia in ED must be considered in context of saturation gap in patients suspected of having toxicological cause. Methemoglobinemia treatment requires methylene blue administration that causes rapid resolution of symptoms.

Topic: Methemoglobinemia and Tumor Lysis Syndrome
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Acquisition and loss of cryotolerance in Livistona chinensis embryos during seed development.

Changes in desiccation tolerance and cryotolerance of chinese fan palm (Livistona chinensis [Jacq.] R. Br.) Embryos were studied during seed development from 15 to 45 weeks after flowering (WAF). Acquisition and then progressive loss in both desiccation tolerance and cryotolerance was observed within this period. Survival (apparent elongation of embryos) and emergence (formation of root and/or shoot) of embryos following dehydration increased progressively with development of seeds until 33 WAF, and then decreased up to 45 WAF. Similar changes occurred in the minimum moisture content at which 90% of embryos survived or emerged. Cryotolerance of embryos was nil at the early stages of seed development, until 21 WAF. Embryos acquired slight cryotolerance at 23 WAF and cryotolerance increased gradually from 27 to 36 WAF, then decreased by 45 WAF. Survival and emergence of post-thaw embryos were closely related to their moisture contents prior to freezing. However, this correlation between cryopreservation and moisture content was notably influenced by the embryos' developmental stage. Embryos at stages with greater cryotolerance gave higher post-thaw survival and emergence at a given moisture content, and the moisture content range allowing embryos to avoid cryo-damage was widened at both the lower and upper limits. Greater than 50% post-thaw emergence was observed only in embryos with moisture contents below 20% (fresh weight) at developmental stages between 27 and 36 WAF, although more than 90% of embryos could be dehydrated to < 20% moisture contents without loss in survival and emergence as early as 21WAF. Nearly 80% embryos could be dehydrated safely to 20% moisture content as late as 45 WAF.

Topic: Seed Germination and Physiology
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Occupational dose assessment of 64Cu-ATSM in a veterinary setting

64Cu-ATSM is an emerging radiopharmaceutical for diagnostic use in Positron Emission Tomography (PET) and has potential utility for radiation therapy but to date there are no studies that assess the occupational doses delivered to workers in either a hospital or veterinary environment. This study consisted of canine patients that were recruited at the Colorado State University James L. Voss Veterinary Teaching Hospital (VTH). The study was aimed at determining the radiation dose to veterinary workers from clinical PET/CT procedures using 64Cu-ATSM. To determine the dose to the workers, each worker was assigned two Electronic Personal Dosimeters (EPDs) to be worn on the chest and waist during the entirety of each procedure. The workers monitored during this study involved included a radiobiologist, a nuclear medicine technician, an anesthesiologist, and a veterinary surgeon. Seven canine patients were imaged over a ten month period with an average mass of 33.7 kg (a range of 20.0 - 55.1 kg) with an average injected activity of 5 MBq kg-1. The dose range for the radiobiologist was 2 -17 µSv, for the nuclear medicine technician 0 -14 µSv, for the anesthesiologist 0 - 12 µSv, and for the surgeon 0 -10 µSv. In a comparison between the results of this study and published literature on occupational exposures from human/veterinary FDG PET/CT procedures, 64Cu-ATSM veterinary PET/CT procedures, on a per patient bias, exposed workers to less radiation.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
An annonated checklist for orchids of Tripura in North-east India

In the present paper, an updated checklist ofoOrchids reported so far from the state of Tripura in Northeast India, based on collection in herbaria and research publications on the flora of the state.Additional informations on habit, phenology, occurrence, herbarium collections, etc. have been included.A total of 83 species of orchids from 40 genera have been identified and enumerated.Of these, 63 are epiphytes and remaining 20 species are terrestrial in habit.The most richest orchid genus in Tripura is Dendrobium with 16 species, which is followed by Coelogyne with 8 species.Orchids like Acampe praemorsa, Aerides odoratum, Cymbidium aloifolium, Dendrobium aphyllum, Micropera pallida, Papilionanthe teres, and Rhynchostylis retusa are very common and are distributed throughout the state.

Topic: Flowering Plant Growth and Cultivation
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Deep Ensemble Learning for Land Cover Classification Based on Hyperspectral Prisma Image

This study investigates the effectiveness of Convolutional Neural Networks (CNN) for land cover classification of hyperspectral PRISMA (PRecursore IperSpettrale della Missione Applicativa) images. Specifically, a deep ensemble learning framework is proposed, mainly to extract pertinent information for accurate classification. In this work, 1D, 2D and 3D CNNs map land cover into the eight classes of waterbody, agriculture under cultivation, agriculture cultivation, build up area, wetland, range, forest, and salt marsh. Comparison with a hybrid-CNN model showed a 2.37% improvement in overall accuracy at 99.93%.

Topic: Remote-Sensing Image Classification
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
CNDs and RTOKs: are we addressing these problems correctly?

High rates of Cannot Duplicates (CNDs) and Retest OKs (RTOKs) in aircraft avionics has led to excessive line and shop maintenance times and maintenance loading. This, in turn, results in decreased sortie rates, long logistic tails, and higher life-cycle cost. Grumman has been addressing these problems, via the development of smart BIT (built-in test) technology. This paper discusses this work and provides strong evidence that intermittent faults may be a major cause of many of the CNDs and RTOKs referred to above. The unique environmental testing that led to this conclusion will be described. Data from the environmental testing led to a rethinking of some of the original smart BIT techniques, resulting in an improved smart BIT implementation. The new integrated approach has two key components: A temporal monitor (TM) that replaces conventional BIT filtering and properly classifies fault behavior; A system level fault correlator (FC) that correlates fault behavior to environmental stress when applicable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Engineering and Test Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
The unspoken voices of apartheid: Confessions of the interregnum

This thesis examines the relationship between silence and confession in Athol Fugard’s Tsotsi, Sindiwe Magona’s Mother to Mother, and J. M. Coetzee’s Disgrace in order to show that the act of confession is often problematic, specifically when some characters choose to remain silent while other characters encourage their speech. The withholding of speech, then, becomes an act of empowerment and a rhetorical endeavor, where silence is more than the absence of speech; it is a way to communicate. Whether silence is to bring about a specific purpose, or is enforced because a character does not understand his or her situation and therefore cannot offer a sincere confession, the character has the power to choose whether or not to confess his or her story. Furthermore, this thesis explores the shift of control in three political climates: During apartheid, at the end of apartheid, and in post-apartheid South Africa in order to reflect the transferal of power from white hands to black hands. As suggested in the novels, the ability to speak correlates with the amount of power a subject has.

Topic: South African History and Culture
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
A CASE OF NON-INVASIVE BREAST CANCER JUST BELOW THE NIPPLE WITH DIFFERENTIATION TO NUEROENDOCRlNE TUMOR

症例は66歳，女性．乳癌検診を目的に当院を受診した．腫瘤は触知せず，乳頭の異常や血性分泌はなく，マンモグラフィ検査でも異常は認められなかったものの，超音波検査で左乳頭直下に，直径6mm大の腫瘤を認めた．マンモトーム生検組織診でinvasive ductal carcinomaと診断され，乳房温存術を行った．術後，組織の再検討を行ったところ，神経内分泌腫瘍への分化を呈した非浸潤性乳癌（NE-DCIS）と最終診断された．NE-DCISは良性的な細胞所見を有することが多く，針もしくはマンモトーム生検で乳頭腫と診断されやすい．本症例のように乳管内増殖病変の診断に苦慮する場合にはNE-DCISが関与していることが多く，文献的考察を加え報告する．

Topic: Breast Lesions and Carcinomas
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
A Case of Minimally Differentiated Acute Leukemia (AML—M0) Complicated by Ventricle Thrombosis During Remission-induction

Sudden chest pain, dyspnea, and tachypnea occurred in a 21-year-old female who was undergoing induction chemotherapy under a diagnosis of minimally differentiated acute leukemia (M0). The arterial blood gas (ABG) tensions were decreased (PO2 71.6 mm Hg, PCO2 23.7 mm Hg), and an electrocardiogram showed a right-bundle branch block. Coagulation abnormalities (PT 73.1%, APTT 39.4 s, FDP 235mg/dl) were observed 72 h before onset. Echocardiography revealed a large thrombus in a right ventricle. A diagnosis of pulmonary thromboembolism (PTE) was made, and a tissue-type plasminogen activator (monteplase) was administered under percutaneous cardiopulmonary support (PCPS). The complete lysis of thrombus was confirmed by an echocardiogram 8 h later. Symptoms and ABG data were also improved. PTE in adult AML cases is rare, but should be considered as one of the life-threatening complications in AML patients under chemotherapy who develop respiratory difficulties. We suggest a careful monitoring of coagulation abnormalities for the prediction of PTE during chemotherapy for AML, and the use of tissue-type plasminogen activator (t-PA), monteplase, for the treatment of PTE in these cases.

Topic: Blood Coagulation and Thrombosis Mechanisms
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Health Workforce Australia Expanded Scopes of Practice Program: evaluation framework

In June 2012, the Centre for Health Service Development (CHSD), University of Wollongong, was appointed by Health Workforce Australia (HWA) as the national evaluator of the Expanded Scopes of Practice (ESOP) Program. This report provides the current iteration of the evaluation framework for HWA Australia's ESOP Program. HWA through this Program has initiated a range of projects that support implementation of the National Health Workforce Innovation and Reform Strategic Framework for Action 2011-2015. The ESOP Program (also referred to as the 'Program'), has been developed as part of the corresponding HWA work plan. This evaluation framework aims to ensure a robust evidence base is developed to support evaluation at the local setting and a national approach for each of the four sub-projects and the Program as a whole. It has been refined in consultation with lead and implementation sites through a combination of teleconferences, meetings and site visits. The introductory workshops (which included Clinical Advisers) that were held for each sub-project in August and September 2012 also provided an opportunity for feedback. The evaluation framework has been presented to each of the three Project Advisory/Reference Groups to gain input from these key stakeholders. Officers of HWA have provided detailed feedback which has been incorporated in this version of the evaluation framework. A set of Key Performance Indicators (KPIs) will be collected for each sub-project in addition to a range of evaluation information to address national evaluation requirements. In combination this data and information will ensure the evaluation reports on the key domains of inquiry for HWA: workforce capacity; effectiveness including the impact and experience for consumers and service providers as well as safety and quality outcomes; economic measures including cost and efficiency; workforce productivity; sustainability and the generalisability or scalability of the implemented models. The evaluation framework will be progressively implemented at all project sites. It will form the basis for future reporting by the National Evaluation Team.

Topic: Primary Care and Health Outcomes
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
CCDC 288210: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Location specific annealing of miR-122 and other small RNAs defines an Hepatitis C Virus 5′ UTR regulatory element with distinct impacts on virus translation and genome stability

Abstract Hepatitis C virus (HCV) replication requires annealing of a liver specific small-RNA, miR-122 to 2 sites on 5′ untranslated region (UTR). Annealing has been reported to (a) stabilize the genome, (b) stimulate translation and (c) promote the formation of translationally active Internal Ribosome Entry Site (IRES) RNA structure. In this report, we map the RNA element to which small RNA annealing promotes HCV to nucleotides 1–44 and identify the relative impact of small RNA annealing on virus translation promotion and genome stabilization. We mapped the optimal region on the HCV genome to which small RNA annealing promotes virus replication to nucleotides 19–37 and found the efficiency of viral RNA accumulation decreased as annealing moved away from this region. Then, by using a panel of small RNAs that promote replication with varying efficiencies we link the efficiency of lifecycle promotion with translation stimulation. By contrast small RNA annealing stabilized the viral genome even if they did not promote virus replication. Thus, we propose that miR-122 annealing promotes HCV replication by annealing to an RNA element that activates the HCV IRES and stimulates translation, and that miR-122 induced HCV genome stabilization is insufficient alone but enhances virus replication.

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Advanced turbine systems sensors and controls needs assessment study. Final report

The Instrumentation and Controls Division of the Oak Ridge National Laboratory performed an assessment of the sensors and controls needs for land-based advanced gas turbines being designed as a part of the Department of Energy`s (DOE`s) Advanced Turbine Systems (ATS) Program for both utility and industrial applications. The assessment included visits to five turbine manufacturers. During these visits, in-depth discussions were held with design and manufacturing staff to obtain their views regarding the need for new sensors and controls for their advanced turbine designs. The Unsteady Combustion Facilities at the Morgantown Energy Technology Center was visited to assess the need for new sensors for gas turbine combustion research. Finally, a workshop was conducted at the South Carolina Energy Research and Development Center which provided a forum for industry, laboratory, and university engineers to discuss and prioritize sensor and control needs. The assessment identified more than 50 different measurement, control, and monitoring needs for advanced turbines that cannot currently be met from commercial sources. While all the identified needs are important, some are absolutely critical to the success of the ATS Program.

Topic: Combustion and flame dynamics
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Experimental assessment of lean-burn characteristics for a modified diesel engine operated in methanol direct injection spark ignition (DISI) mode at full throttle condition

In this study, the lean-burn characteristics of a high-compression direct injection spark ignition (DISI) methanol engine were investigated. The tests were conducted on a modified diesel engine in methanol DISI mode at three excess air ratios (1.2, 1.3, and 1.4) and injection timings from −60° to −300° crank angle (CA) after top dead center (ATDC). The engine was run at 1500 rpm, 100% throttle opening, and spark timing at maximum brake torque condition. The results demonstrated that the test engine under lean-burn condition can obtain the higher indicated thermal efficiency (ITE), but the lower indicated mean effective pressure (IMEP). The THC, CO, CO2 and NOX emissions are all reduced with the increased λ. Injection timing had a large influence on the combustion and emissions and these influences became largely in the case of retarded injection conditions. There existed an optimum injection timing of −240 °CA ATDC where the IMEP and ITE got their highest values along with the lowest coefficient of variation in indicated mean effective pressure (COVIMEP). Meanwhile, the THC and CO emissions are lowest, but the CO2 and NOX emissions highest. The methanol engine can obtain the maximum toque of 27.6 N·m, which is 25.3% more than the original diesel engine at the same speed. Meanwhile, there was no knocking throughout the entire experiment, and the maximum pressure rise rate and COVIMEP were found to be 0.4 MPa and 4.1%, and those are much less than the critical points of 1.0 MPa and 5%, respectively.

Topic: Advanced Combustion Engine Technologies
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
A patient with spastic paralysis finally diagnosed as V180I genetic Creutzfeldt-Jakob disease 9 years after onset

Genetic Creutzfeldt-Jakob disease (gCJD) with a mutation in codon 180 of the prion protein gene (V180I gCJD) is the most common form of gCJD in Japan, but only a few cases have been reported in Europe and the United States. It is clinically characterized by occurring in the elderly and presenting as slowly progressive dementia, although it generally shows less cerebellar and pyramidal symptoms than sporadic CJD. Here, we report a patient with V180I gCJD who initially presented with slowly progressive spastic paralysis with neither cerebrospinal fluid (CSF) nor magnetic resonance imaging (MRI) abnormalities. His symptoms progressed gradually, and after 9 years, he displayed features more typical of CJD. Diffusion-weighted MRI revealed high-intensity signals in the cortical gyrus, and there was a marked increase of 14-3-3 protein and total tau protein in the CSF, but he was negative for the real-time quaking-induced conversion assay. Although the time course was more consistent with Gerstmann-Sträussler-Scheinker disease than CJD, genetic testing revealed V180I gCJD. This is the first report of a patient with V180I gCJD who initially presented with spastic paralysis, and also the first to reveal that it took 9 years from disease onset for cortical dysfunction to develop and for MRI and CSF abnormalities to be detectable. In conclusion, we should screen for V180I gCJD in elderly patients presenting with slowly progressive spastic paralysis.

Topic: Prion Diseases and Protein Misfolding
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
551 A retrospective study of sternal metastases in breast cancer

<h3>Introduction/Background</h3> Sternal metastases of breast cancer are rare. Their occurrence is due to the spread of malignant cells via the hematogenous route or via a local pathway from the internal mammary nodes. The aim of this study is to define the different pattern of sternal malignant abnormalities on bone scan. <h3>Methodology</h3> It is a retrospective study including breast cancer patients, referred for bone scan during 2019, at the Nuclear Medicine department of Tlemcen University Hospital in Algeria. Two hours after the intravenous injection of 8–10 MBq/kg 99mTc-HMDP, whole body scanning is accomplished by dual head hybrid gamma camera with low energy high resolution collimator. The SPECT/CT (single photon emission tomography/computed tomography) acquisition is used to better characterize the presence, location, and extent of disease in some patients. <h3>Results</h3> A total of 54 malignant sternal abnormalities were found in 500 breast cancer patients (10,8%). Half of the lesions (27 cases) were located in the sternal body, 17 (32%) in the manubrium and 10 (18%) in the entire bone structure. The majority of sternal abnormalities (47 cases; 87%) was found as a part of multiple metastases, while only 2 cases (4%) as a part of oligometastases and 5 cases (9%) as the initial site of bone metastases. A solitary sternal uptake on bone scan is difficult to interpret due to various etiologies, both benign and malignant. The SPECT/CT acquisition has allowed us to define the secondary origin of the radioactivity uptake after cross sectional study and confrontation with morphological imaging. The predominant scintigraphic pattern was that of hot lesions (48 cases; 89%), which highlights an osteoblastic hyperactivity. A cold lesion representing an osteoclastic activity, is rarely seen in bone scan until it is surrounded by an increased radioactivity uptake. The latter aspect was found in 6 patients (11%). <h3>Conclusion</h3> Radionuclide bone scintigraphy is a useful tool for recognizing sternal abnormalities in breast cancer patients. <h3>Disclosures</h3> We have no disclosures.

Topic: Cancer Diagnosis and Treatment
Subfield: Oncology
Field: Medicine
Domain: Health Sciences