jimnoneill/paper-to-field-training huggingface dataset:
An Integrated Model for Managing Organizational Change

ABSTRACT. Changes in organizations, both planned and unplanned, respond to forces from within and outside organizations. Management of change requires vigilance because change affects people’s work, powers, and interactions. According to the existing models of change, people either accept or resist change. However, in order to maintain equilibrium, people influence the process of change. So, they may not only resist or accept change, but may also deviate the desired out omes. To concede this fact, a more effective framework has been developed and presented here to better understand the change process. According to this framework, the key to successful change is to diagnose the organization with its people as an integral part of it, map a comprehensive action plan, and be prepared to intervene repeatedly until the desired results are achieved.

Topic: Organizational Change and Leadership
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Differential regulation of vitamin D receptor expression in distinct leukemic cell lines upon phorbol ester-induced growth arrest

A close correlation between vitamin D receptor (VDR) abundance and cell proliferation rate has been shown in NIH-3T3 fibroblasts, MCF-7 breast cancer and in HL-60 myeloblastic cells. We have now determined if this association occurs in other leukemic cell lines, U937 and K562, and if VDR content is related to c-myc expression, which is also linked to cell growth state. Upon phorbol myristate acetate (PMA) treatment, cells from the three lineages (HL-60, U937 and K562) differentiated and expressed specific surface antigens. All cell lines analyzed were growth inhibited by PMA and the doubling time was increased, mainly due to an increased fraction of cells in the G0/G1 phase, as determined by flow cytometry measurements of incorporated bromodeoxyuridine and cell DNA content. C-myc mRNA expression was down-regulated and closely correlated to cell growth arrest. However, VDR expression in leukemic cell lines, as determined by immunofluorescence and Northern blot assays, was not consistently changed upon inhibition of cell proliferation since VDR levels were down-regulated only in HL-60 cells. Our data suggest that VDR expression cannot be explained simply as a reflection of the leukemic cell growth state.

Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Data from EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway

&lt;div&gt;Abstract&lt;p&gt;The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated with worse patient survival. Gain-of-function and loss-of-function studies demonstrated that PNO1 knockdown suppressed growth of colorectal cancer cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;, while PNO1 overexpression promoted colorectal cancer cell proliferation &lt;i&gt;in vitro&lt;/i&gt;. In colorectal cancer cells expressing wild-type p53, PNO1 knockdown enhanced expression of p53 and its downstream gene p21, and reduced cell viability; these effects were prevented by p53 knockout and attenuated by the p53 inhibitor PFT-α. Moreover, PNO1 knockdown in HCT116 cells decreased levels of 18S rRNA, of 40S and 60S ribosomal subunits, and of the 80S ribosome. It also reduced global protein synthesis, increasing nuclear stress and inhibiting MDM2-mediated ubiquitination and p53 degradation. Overexpressing EBF1 suppressed PNO1 promoter activity and decreased PNO1 mRNA and protein, inhibiting cell proliferation and inducing cell apoptosis through the p53/p21 pathway. In colorectal cancer tissues, the expression of EBF1 correlated inversely with PNO1. Data mining of online breast and lung cancer databases showed increased PNO1 expression and association with poor patient survival; PNO1 knockdown reduced cell viability of cultured breast and lung cancer cells. Taken together, these findings indicate that PNO1 is overexpressed in colorectal cancer and correlates with poor patient survival, and that PNO1 exerts oncogenic effects, at least, in part, by altering ribosome biogenesis.&lt;/p&gt;Significance:&lt;p&gt;This study identifies the ribosome assembly factor PNO1 as a potential oncogene involved in tumor growth and progression of colorectal cancer.&lt;/p&gt;&lt;/div&gt;

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Enhancing Biodiversity in Urban Green Space; An Exploration of the IAD Framework Applied to Ecologically Mature Trees

This paper investigates how institutions in urban settings potentially identify, frame, and operationalise biodiversity conservation policies. It adopts the Institutional Analysis and Development Framework (IAD) to analyse a case study regarding the retention of ecologically mature trees in urban green space in Canberra, Australia. The research investigates; what are the structural and institutional arrangements that catalyze or inhibit biodiversity conservation in urban green space? Specifically, the IAD framework is applied to explore the institutional structures and the role of key decision-makers in the conservation and management of ecologically mature trees in urban green space. Ecologically mature trees represent an exclusive habitat for many species and are key structures for conserving biodiversity in urban settings. The results suggest the application of the IAD ‘rules-in-use’ analysis reveals that ecologically mature trees are inconsistently managed in Canberra, leading to conflicting approaches between institutions in managing urban biodiversity. It suggests that a more structured and replicable institutional analysis will help practitioners to empirically derive a more comprehensive understanding of the roles of institutions in supporting or inhibiting biodiversity conservation in urban settings. The research finds that developers, asset managers, and other stakeholders could benefit from explicitly mapping out the defined rules, norms and strategies required to negotiate economically, socially and environmentally achievable outcomes for biodiversity conservation in urban green space.

Topic: Land Use and Ecosystem Services
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
Investigations on Foam Detection Utilizing Ultra-Broadband Millimeter Wave FMCW Radar

Foaming impairs the efficiency in several processes of the chemical industry. An early foam detection is advantageous to solve this problem. In this work we investigate the detection of foam by means of radar distance measurements utilizing a low noise 80 GHz FMCW radar with 25 GHz bandwidth. Two foaming solutions with several majority sizes of the air inclusions are used. First, a water butanol solution creates very fine foam. The foam surface is the only measurable reflection. However, it can be distingushed from a refelction at a liquid surface by means of the amplitude. Secondly, a water tenside solution creates fine to coarse foam. The foam surface as well as the liquid surface underneath exhibit a measurable reflection. The finer the foam is, the stronger the reflection at the foam surface and the weaker the reflection at the liquid surface is. Thus, the detection of foam by means of millimeter wave radar measurements is possible.

Topic: Microwave and Dielectric Measurement Techniques
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Wax Moth Pheromone, Moth Influence, and Associated Glands

The wax moth male secretes various pheromones to attract the female for mating. The volatiles induce species-specific influence, which modulates the behaviour of other members of the same species. The primary pheromones include nonanal and undecanal, hexanal, heptanal, octanal, decanal, undecanol, and 6, 10, 14 - trimethylpentadecanon-2. The specific chemicals are secreted by a pair of glands on the forewings of the male moth in the greater and lesser wax moth. These volatiles are essential for the adult stage and plays a critical role in larval and pupal aggregation. The specific chapter elaborates on the chemical composition of the pheromones, their influence on the conspecific individuals, and their role in modulating the mating behaviour, in the case of the greater wax moth (GWM) and the lesser wax moth (LWM).&lt;br&gt;

Topic: Insect Pheromone Research and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
HLA-A,B and DR antigens in chronic lymphocytic leukaemia.

Eighty-three patients with B cell chronic lymphocytic leukaemia were typed for HLA-A,B, and DR antigens. HLA-A2 was found to be significantly increased in patients compared to controls. The frequency of antigens A2,B12(44),DR7 occurring together was more than double the frequency found in the controls. In 48 patients requiring treatment, there was a significant reduction of B8 when compared to 34 untreated patients, and DR7 was significantly increased in frequency in treated patients. Thirty patients presented with sub-clinical symptoms (Rai stage 0). HLA-A10 was significantly more common than in those patients presenting with more advanced disease (Rai stages 1-4). The highest frequency of any HLA antigen was found in males presenting with clinical symptoms, 71.0 per cent of whom were A2 positive; in the same group, 22.6 per cent of patients were positive for all the antigens A2,B12(44),DR7. Patients with an age of onset greater than the mean age of 69 years were more likely to be A2 positive. We conclude that HLA-B8 is a marker of mild disease while HLA-A2 and the closely associated antigens B12(44) and DR7 are markers for severe disease.

Topic: Chronic Lymphocytic Leukemia Research
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Development of a system for building a cloud-based digital twin as an informational assistance system for context-based dynamic configuration of cyber-physical hybrid production systems

Due to constantly changing conditions, demand, and technologies, companies increasingly seek flexibility. Productivity results from automation, improved working conditions and the focus of people in production in interaction with machines. Unfortunately, the human factor is often not considered to increase flexibility and productivity with new concepts. This work aims to develop a hybrid assistance system that allows a dynamic configuration of cyber-physical production systems considering the current order situation and available resources utilizing simulation. The system also considers human factors in addition to economic factors, which contributes to the extended economic appraisal.

Topic: Digital Transformation in Industry
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Serine at the Active Center of Yeast Carboxypeptidase

Abstract Carboxypeptidase Y from bakers' yeast is a diisopropyl phosphorofluoridate (DFP)-sensitive enzyme. The inactivation by [32P]DFP is accompanied by the formation of 1 mole of labeled serine per mole of enzyme. A 15-residue 32P-labeled (*) peptide has been isolated from a peptic digest and shown to have the sequence His-Ile-Ala-Gly-Glu-Ser*-Tyr-Ala-His-Gly-Tyr-Ile-Pro-Val-Phe. The reaction of the serine residue with DFP is blocked by the presence of p-hydroxymercuribenzoate, which also inactivates the enzyme. The single —SH group of the protein may be near the active center of the enzyme, but the —SH group is not available to iodoacetate or iodoacetamide in the absence of denaturants. The sequence around the reactive serine residue and the properties of the —SH group contribute to an active site which is quite different from that of DFP-sensitive proteinases such as trypsin, chymotrypsin, or subtilisin.

Topic: Biotin and Related Studies
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Development, Ecology and Climate Change: Resistance by the Peasantry

Critical theory like political ecology and peasant studies point to the insufficiency of adaptation strategies and call for more radical alternatives, such as the abandonment of development strategies based on fossil-fuelled industrialisation and urban-centred economic growth. They favour rural livelihood strategies based on sustainable natural resource management and organic/agro-ecological production, thus combining genuine development with resistance to the hegemony of that neoliberal-driven transformation of fundamental socio-economic structures in developing countries. This is associated with detrimental climatic and ecological consequences. This article offers a theoretical and conceptual framework for understanding the nexus of development, ecology and climate change, and explores significant patterns of community resistance evolving into promising strategies of reactions ‘from below’ against growth-driven development implicating ecocide. Such resistance opposes the regional and global obsession with excessive growth and poses new challenges to the international political system.

Topic: Agriculture, Land Use, Rural Development
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Obtaining seeds of meadow clover in the Lower Volga region under irrigation

Abstract. The purpose of the experiment was to develop a technology for cultivating meadow clover under irrigation to obtain the planned seed yields in the conditions of the Lower Volga region. Research methods. Field experiments, records and observations were carried out in accordance with the generally accepted methods of experimental work. As a result of the research, it was found that the total water consumption of clover crops varied over the years of the herbage life and depended on the given pre-irrigation threshold of soil moisture. It was highest in the variants with the maintenance of the 70 % pre-flood threshold: 3.6–3.9, the lowest 2.7–3.1 thousand m3/ha in the variants with the 60 % humidity threshold. With the differentiation of humidity by the development phases, the total water consumption varied from 3.1 to 3.5 thousand m3/ha. The share of irrigation water in the structure of total water consumption was 60.6–72.7 % according to the experimental variants. The leaf area depended on the water and nutrient regimes of the soil: it reached the maximum values in the variants with a 70 % pre-irrigation threshold of humidity and fertilization. In comparison with the increase in biomass, the seed productivity of clover was less dependent on the photosynthetic potential and assimilation surface. The highest seed yields were formed in the variants with improved nutrition background and maintenance of a differentiated irrigation regime – 280–730 kg / ha. The accumulation of a significant amount of root mass by clover had a positive effect on improving the ecological state of the irrigated area: the water-physical properties of the soil improved, and nutrients accumulated in it. Scientific novelty. In the conditions of the Lower Volga region, the dependence of the seed productivity of clover on the availability of water and nutrients, on the age of the herbage, was revealed. Their optimal combination is determined for the production of seed yields at the level of 400–700 kg/ha.

Topic: Agricultural Productivity and Crop Improvement
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
BUBER'S HERMENUTICS: THE ROAD TO THE REVIVAL OF THE COLLECTIVE MEMORY AND RELIGIOUS FAITH

Journal Article BUBER'S HERMENUTICS: THE ROAD TO THE REVIVAL OF THE COLLECTIVE MEMORY AND RELIGIOUS FAITH Get access Ehud luz Ehud luz Search for other works by this author on: Oxford Academic Google Scholar Modern Judaism - A Journal of Jewish Ideas and Experience, Volume 15, Issue 1, February 1995, Pages 69–93, https://doi.org/10.1093/mj/15.1.69 Published: 01 February 1995

Topic: Jewish and Middle Eastern Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Sea-surface temperatures predict targeted visual surveys of octopus abundance

In upwelling systems around the world, octopus abundance is forecast by marine productivity linked to upwelling strength, often indicated by sea-surface temperatures. Climate change may disrupt populations of marine animals that are linked to such temperature-dependent events. We analysed the relationship of the abundance of giant Pacific octopuses (Enteroctopus dofleini) to Gulf of Alaska and Washington State water temperatures. Abundance was measured in targeted visual surveys in Prince William Sound, Alaska, over the period 1995–2016 and from REEF.org diver surveys in Washington State from 2003 to 2019. Octopus counts from both survey programs had significant negative correlations with water temperatures over the previous 2.5–4 years. Water temperature accounted for from 0.41 to 0.71 of the variance (R2) in octopus abundance in eastern Gulf of Alaska waters located in ocean currents up-stream of the survey areas, and up to 0.81 of the variance in Washington State waters. These negative correlations provide a possible predictive index for octopus abundance as measured by targeted visual surveys. These methods may be useful tools in management of octopuses and indicate impacts of climate change on North Pacific coastal marine ecosystems.

Topic: Cephalopods and Marine Biology
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Effect on scattering of complex morphology of DKDP bulk damage sites

Bulk damage sites in frequency conversion crystals scatter and/or absorb laser light leading to interference and downstream intensification .We find that laser induced bulk damage sites in DKDP exhibit a 'shell' of structurally and/or chemically modified material surrounding a central core as indicated by SEM and optical micrographs and micro Raman spectral maps. We hypothesize that the modified material has been shock wave densified and estimate the amount of densification and its effect on scattering. A simple model indicates that densification of several percent is likely and that the scattering cross section may be larger than the geometric area of the inner core by an order of magnitude.

Topic: Spectroscopy Techniques in Biomedical and Chemical Research
Subfield: Biophysics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity

Abstract Objectives This study investigated the antiproliferative and apoptotic activities of CPUYJ039, a newly synthesized benzimidazole-based kinesin spindle protein (KSP) inhibitor, on HCT116 cell lines. Methods KSP-inhibitory activity was tested using the malachite-green method. The in-vitro cell proliferation inhibitory activity of the sample was measured using WST reagent. Flow-cytometric evaluation of cellular DNA content was performed. Apoptotic cells were quantified by annexin V-FITC-PI double staining. To confirm that the cytotoxic activity was a consequence of KSP inhibition, microtubule morphology and DNA segregation were observed by double staining of microtubules and DNA. The expression of Bcl-2 and Bax in CPUYJ039-treated HCT116 cells was detected by Western blotting. Key findings CPUYJ039 was evaluated and proved to have potent inhibitory activities in the KSP ATPase and HCT116 cell proliferation assays. CPUYJ039 inhibited the proliferation of HCT116 cells in a dose- and time-dependent manner and markedly induced G2/M phase cell-cycle arrest with characteristic monoastral spindles and subsequent cell death in HCT116 cells, which was associated with an increase of the Bax/Bcl-2 ratio. Conclusions These results suggest that CPUYJ039 may be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity.

Topic: Microtubule and mitosis dynamics
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Associations of LDL-C-to-HDL-C and TG-to-HDL-C Ratios with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Prospective Cohort Study with 6 years’ Follow-Up

<title>Abstract</title> Background: Traditional blood lipids play an important role in diabetes and cardiovascular diseases, but the evidences were not enough . The lipoprotein indices of low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratios may be the predictive parameters to diabetes and cardiovascular disease. Methods: A 6-year follow-up study was performed in 22,649 subjects (were aged 18–95 years old) without a history of cardiovascular disease (CVD) or diabetes. The information about cardiovascular disease and T2DM was extracted from the Disease Surveillance Points (DSP) system in 2019. Biochemical and demographic variables were acquired by laboratory test and the face-to-face interview with structured questionnaire, the response rate was 88.9%. Lipid ratios were stratified by tertile to ascertain the hazard ratio (HR) of diseases by Cox proportional hazard model. Results: The mean age of subjects was 54.9(14.5) years, 41.9% were males. LDL-C /HDL-C was strongly associated with coronary heart disease (CHD) ( second vs. first tertile: HR, 1.86; 95% CI, 1.03-3.37, p =0.04 ; third vs. first tertile: HR, 3.29; 95% CI, 1.91-5.69, p&lt; 0.001), meanwhile the TG/HDL-C was specifically associated with type 2 diabetes mellitus (T2DM) (second vs. first tertile: HR, 1.56; 95% CI, 1.2-2.02, p =0.001; third vs. first tertile: HR, 2.7; 95% CI, 2.13-3.43, p&lt; 0.001). Moreover, the HR, of diseases was increased with LDL-C, TG/HDL-C ratios. The results of sensitivity analysis revealed the associations of LDL-C, TG/HDL-C ratios with CHD and T2DM were independent on confounders. Conclusion: Our findings suggested that the LDL-C/HDL-C ratio and TG/HDL-C ratio associated with CHD and T2DM , and hazard ratio of disease increased with lipoprotein derived indices.

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Detection of Mesothelioma-Specific ENOX2 Isoforms 4-10 years in Advance of Clinical Symptoms

Malignant mesothelioma is the most common cancer induced by exposure to asbestos. Recently, a retrospective analysis of banked serum samples collected from individuals who developed asbestos-induced mesothelioma was undertaken to determine if ENOX2 isoforms may serve as biomarkers for this disease and to investigate how long in advance of clinical symptoms ENOX2 proteins could be detected in patient sera. Interestingly, two mesothelioma-specific ENOX2 isoforms were detected in serum samples of asbestosexposed individuals, 4-10 years in advance of a clinical diagnosis of mesothelioma (1). This is the very first published evidence that the ONCOblot test is able to detect ENOX2 produced by a malignancy in advance of clinical symptoms. This work was a collaboration between MorNuCo Inc. and Drs. Jenette Creaney, A. W. Musk and Bruce Robinson of the National Center for Asbestos Related Diseases and the School of Medicine and Pharmacology at the University of Western Australia.

Topic: Occupational and environmental lung diseases
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences