jimnoneill/paper-to-field-training huggingface dataset:
Role of Pregabalin in Treatment of Polyneuropathy in Multiple Myeloma Patients: A Retrospective Study

Objectives Polyneuropathy (PN) is a frequent and significant clinical manifestation of multiple myeloma that may be observed at onset of disease or induced during treatment as a therapy-related complication. Polyneuropathy may be a relevant issue in myeloma patients owing to its significant impact on the quality of life, considering that it may lead to dose reduction or treatment discontinuation. The present retrospective study intended to evaluate efficacy of pregabalin (PGB) in treatment of PN in multiple myeloma patients. Materials and Methods Medical charts of 108 consecutive PN myeloma patients were reviewed. Data regarding the tumor history and therapy as well as the clinical and neurophysiological examinations 6 months before and after initiation of PGB therapy were collected. Results Thirty-eight medical charts had all the requested information. All patients (n = 38) underwent bortezomib-based treatment; 19 were previously treated and 19 were treatment naive. At first neurologic visit, all patients had PN symptoms (grade 2 of National Cancer Institute—Common Toxicity Criteria) without relevant pain. Neurophysiological evaluation showed a significant decrease in sensory nerve action potential amplitude ( P = 0.006), conduction velocity ( P = 0.006), and distal latency ( P = 0.03) of sensory nerves between the first and the last neurological examination, in all patient population. Similar results were observed in treatment-naive patients, when the study cohort was stratified according to previous treatment. On the contrary, no significant differences were found between the first and the last neurophysiological follow-up evaluation in previously treated patients. Six months after PGB treatment, all patients reported disappearance of neurological symptoms (grade 0 National Cancer Institute—Common Toxicity Criteria). Conclusions In this retrospective study, improvement in neurological symptoms during PGB therapy was observed in the total population, despite the presence of a distal, sensory axonal neuropathy, as evidenced by neurophysiological examination.

Topic: Cancer Treatment and Pharmacology
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Sensitivity of Rural Households’ Livelihood Strategies to Livelihood Capital in Poor Mountainous Areas: An Empirical Analysis in the Upper Reaches of the Min River, China

Exploring the sensitivity of rural households’ livelihood strategies to livelihood capital is of great significance for improving rural households’ livelihood levels. This paper selects 23 livelihood capital measurement indicators and conducts an in-depth survey of rural households. In addition, the entropy method and a weighted comprehensive model are used to explore the basic characteristics of rural households’ livelihood capital in the upper reaches of the Min River, China, in 2017. Furthermore, econometric models are used to analyze the sensitivity of rural households’ livelihood strategies to livelihood capital. As indicated from the research, the livelihood capital levels of different types of rural households in the study area are not equivalent. The types of rural households with different livelihood strategies can be ordered in terms of quantity as follows: non-agricultural type &gt; non-agricultural dominant type &gt; agricultural dominant type &gt; pure agricultural type. Livelihood strategies have different sensitivities to different livelihood capital measurement indicators. Among these indicators, cash income, the number of relatives and friends available for financial assistance, and the number of civil servants have positive effects on the livelihood strategy selection of non-agricultural dominant rural households and non-agricultural rural households. However, the average age of laborers, area of cultivated land and gardens, number of livestock and poultry, and present value of production tools have negative effects. These evaluation results can provide a scientific decision-making basis for the formulation of poverty alleviation policies by relevant government departments.

Topic: Agricultural Innovations and Practices
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Prenatal Detection of Ischemic Changes in the Placenta of the Growth-Retarded Fetus by Doppler Flow Velocimetry of the Maternal Uterine Artery

Objective: To determine the relationships among the pregnancy outcomes of growth-retarded fetuses, Doppler flow velocimetry of the fetomaternal circulation, and pathologic changes in the placenta. Methods: Forty-seven fetuses confirmed to be growth-retarded by ultrasonographic biometry were monitored during pregnancy in terms of the resistance indexes of the maternal uterine, fetal umbilical, and fetal middle cerebral arteries. After delivery, the placentas were examined for pathologic changes such as infarction and villous ischemia. Results: Compared with 23 fetuses with nonischemic placentas, 24 growth-retarded fetuses whose placentas showed ischemic lesions were more frequently delivered preterm (P< .001) and by cesarean for fetal distress (P< .01), and they also had lower mean pH, higher carbon dioxide pressure, and lower oxygen pressure values (P< .05). Compared with the fetal umbilical and middle cerebral artery resistance indexes, the uterine artery resistance index showed the highest sensitivity (91.7%), specificity (78.3%), and positive predictive value (81.5%) for detecting placental ischemic changes. Linear discriminative analysis also showed that the uterine artery resistance index had the strongest correlation (P< .00001) with the placental ischemic changes. Conclusion: Ischemia of the placenta is associated with an adverse pregnancy outcome in growth-retarded fetuses. The placental ischemic changes can be detected using Doppler flow velocimetry. Measurement of the uterine artery resistance index might be useful for determining the clinical management of growth-retarded fetuses.(Obstet Gynecol 1993;82:494-9)

Topic: Pregnancy and preeclampsia studies
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
<i>Chlamydia pneumoniae</i> and <i>Chlamydia Trachomatis</i> Infection Differentially Modulates Human Dendritic Cell Line (MUTZ) Differentiation and Activation

Abstract Chlamydia trachomatis and Chlamydia pneumoniae are important human pathogens that infect the urogenital/anorectal and respiratory tracts, respectively. Whilst the ability of these bacteria to infect epithelia is well defined, there is also considerable evidence of infection of leucocytes, including dendritic cells ( DC s). Using a human dendritic cell line ( MUTZ ), we demonstrate that the infection and replication of chlamydiae inside DC s is species and serovar specific and that live infection with C. pneumoniae is required to upregulate costimulatory markers CD 80, CD 83 and human leucocyte antigen ( HLA )‐ DR on MUTZ cells, as well as induce secretion of interleukin ( IL )‐2, IL ‐6, IL ‐8, IL ‐12 (p70), interferon‐gamma and tumour necrosis factor‐alpha Conversely, C. trachomatis serovar D failed to upregulate DC costimulatory markers, but did induce secretion of high concentrations of IL ‐8. Interestingly, we also observed that infection of MUTZ cells with C. pneumoniae or C. trachomatis serovar L2, whilst not replicative, remained infectious and upregulated lymph node migratory marker CCR 7 mRNA . Taken together, these data confirm the findings of other groups using primary DC s and demonstrate the utility of MUTZ cells for further studies of chlamydial infection.

Topic: Reproductive tract infections research
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
A service‐based runtime environment for native applications

Abstract Unlike interpreted application programs that run within the rich runtime environment of their own interpreters, natively compiled application programs are typically thought of as executing on the barebones runtime environment provided by their own operating systems and dynamic linkers. This article presents the notion of a service‐based runtime (SBRT) environment for natively compiled application programs, in which the current dynamic linker is only a core service and other extensive middleware‐type services are available to the running application program. It then describes a dynamic‐linker‐based implementation of such an environment, called dlSBRT . dlSBRT implements a unified interface that allows it to be extensible by means of extension dynamic services. Implemented examples of such services are presented and the performance of dlSBRT , when such example services are deployed, is evaluated. Copyright © 2009 John Wiley &amp; Sons, Ltd.

Topic: Distributed and Parallel Computing Systems
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
An overview of management information systems

research-article Free Access Share on An overview of management information systems Author: James C. Emery The Wharton School The Wharton SchoolView Profile Authors Info & Claims ACM SIGMIS Database: the DATABASE for Advances in Information SystemsVolume 5Issue 2-3-4Winter 1973 pp 1–15https://doi.org/10.1145/2579442.2579443Online:01 December 1973Publication History 7citation79DownloadsMetricsTotal Citations7Total Downloads79Last 12 Months10Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF

Topic: Information Technology Governance and Strategy
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Evaluation Framework and Analyses for Thermal Energy Storage Integrated with Packaged Air Conditioning

Few third-party guidance documents or tools are available for evaluating thermal energy storage (TES) integrated with packaged air conditioning (AC), as this type of TES is relatively new compared to TES integrated with chillers or hot water systems. To address this gap, researchers at the National Renewable Energy Laboratory conducted a project to improve the ability of potential technology adopters to evaluate TES technologies. Major project outcomes included: development of an evaluation framework to describe key metrics, methodologies, and issues to consider when assessing the performance of TES systems integrated with packaged AC; application of multiple concepts from the evaluation framework to analyze performance data from four demonstration sites; and production of a new simulation capability that enables modeling of TES integrated with packaged AC in EnergyPlus. This report includes the evaluation framework and analysis results from the project.

Topic: Building Energy and Comfort Optimization
Subfield: Building and Construction
Field: Engineering
Domain: Physical Sciences
VIRAL BIOSAFETY OF BIOPHARMACEUTICALS

Therapeutics produced by eukaryotic cell lines could possible be contaminated with bioburden; the most dangerous for human is viral contamination. The article describes the problem of viral safety of biopharmaceuticals. The strategy of downstream process steps for the viral safety guarantee is discussed. The methods of viral inactivation, filtration, purification are given in the paper.

Topic: Biosimilars and Bioanalytical Methods
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Pulsating unilateral exophthalmos due to traumatic aneurysm of the intraorbital ophthalmic artery

✓ A case of pulsating unilateral exophthalmos is presented. It was caused by a traumatic aneurysm of the intraorbital ophthalmic artery, secondary to missile injury. Evolution of the aneurysm was observed clinically, by angiography, and by computerized tomography. The differential diagnosis of pulsating exophthalmos and the pathogenesis of such aneurysms are briefly discussed.

Topic: Facial Trauma and Fracture Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Allium�hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma mouse model

In 2013, WHO estimated that approximately 235 million people suffered from asthma worldwide. Asthma is a hyper responsive disorder, which is related to an imbalance between the T‑helper type 1 and 2 cells (henceforth, Th1 and Th2, respectively). Allium hookeri is a plant that is widely used for culinary purposes and also in traditional Asian medicine. The present study was conducted to elucidate the anti‑asthmatic effects and mechanism of action of A. hookeri root extracts (AHRE) in an ovalbumin (OVA)‑induced asthma mouse model. The mice were divided into five groups, namely, the control, the OVA‑treated group, the dexamethasone‑treated group, the 30 mg/kg AHRE‑treated group, and the 300 mg/kg AHRE‑treated group. The total WBC count and the differential cell count in the bronchoalveolar fluid, the level of serum IgE, the histopathological changes in the lung, and changes in the cell surface molecules, the asthma‑related cytokine levels, and Th cell transcription factors were evaluated. AHRE significantly ameliorated asthmatic changes, such as the total WBC count, eosinophil count, and the level of IgE; in addition, it reduced mucus hypersecretion, epithelial hyperplasia, and eosinophil infiltration in the lungs. AHRE significantly inhibited the expression of CD68+ cells and MHC class II+ molecules, Th1 cell transcription factor (T‑bet) activation, Th2 cell transcription factor (GATA‑3) activation, and TNF‑α in the lung tissue. Furthermore, it suppressed cell surface molecules, such as CD4+and CD8+; Th1‑related cytokines, such as IFN‑γ and IL‑12p40; Th2‑related cytokines, such as IL‑4 and IL‑5; and Th17‑related cytokines, such as IL‑6 and TNF‑α, in a dose‑dependent manner. Thus, AHRE may be considered a promising anti‑asthmatic drug.

Topic: Asthma and respiratory diseases
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Political Television Advertising in Campaign 2000

Most studies of political advertising focus on presidential television spots. However, far more commercials are broadcast for other races. This study applies the functional theory of political campaign discourse to 584 television spots from presidential, gubernatorial, senatorial, house, and local races in the 2000 election. The most common functions were acclaims (67%) followed by attacks (32%) and defenses (1%). When non-presidential ads are examined, incumbents acclaimed more and attacked less than challengers. Party-sponsored ads employed more attacks than ads sponsored by the candidates. These messages emphasized policy more than character (62% against 38%). Democratic candidates discussed policy more than Republicans. Presidential and gubernatorial ads (executive offices) discussed policy more than ads for other offices.

Topic: Media Studies and Communication
Subfield: Communication
Field: Social Sciences
Domain: Social Sciences
Reply on RC1

<strong class="journal-contentHeaderColor">Abstract.</strong> Lakes experience anthropogenically-forced changes that may initiate ecosystem feedbacks, in some cases reaching tipping points beyond which impacts become hard to reverse. Lakes are also important players in the global climate by ventilating a large share of terrestrial carbon back to the atmosphere as greenhouse gases, and will likely provide substantial feedbacks to climate change. In this paper we address various major changes in lake ecosystems, and discuss if tipping points can be identified, predicted, or prevented in them, along with their associated feedbacks to climate change. Potential tipping dynamics assessed include eutrophication-driven anoxia and internal phosphorus-loading, increased loading of organic matter from terrestrial to lake ecosystems (lake &ldquo;browning&rdquo;), lake formation or disappearance in response to cryosphere shifts, switching from nitrogen to phosphorus limitation, salinization, and the spread of invasive species. We also address other types of abrupt, or threshold-type shifts in lakes and ponds, and conclude on which tipping points are locally or regionally relevant. We identify a key set of co-drivers that could lead to self-sustaining feedbacks, with warming, browning, and eutrophication leading to increased lake stratification, heterotrophy, and algal mass, which separately or collectively drive benthic oxygen depletion and in turn increased greenhouse gas emissions (helping to drive further warming and organic matter loading) and internal phosphorus-loading (driving further eutrophication). Several of these processes can feature tipping points, which further warming will likely make easier to reach. We argue that the full importance of the vulnerability of lakes to climate and other anthropogenic impacts, as well as their feedback to climate is not yet fully acknowledged, so there is a need both for science and communication in this regard.

Topic: Aquatic Ecosystems and Phytoplankton Dynamics
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Search for scalar induced gravitational waves in the International Pulsar Timing Array Data Release 2 and NANOgrav 12.5 years datasets

We perform a Bayesian search in the latest Pulsar Timing Array (PTA) datasets for a stochastic gravitational wave (GW) background sourced by curvature perturbations at scales $10^5~\text{Mpc}^{-1}\lesssim k\lesssim 10^8~\text{Mpc}^{-1}$. These re-enter the Hubble horizon at temperatures around and below the QCD crossover phase transition in the early Universe. We include a stochastic background of astrophysical origin in our search and properly account for constraints on the curvature power spectrum from the overproduction of primordial black holes (PBHs). We find that the International PTA Data Release 2 significantly favors the astrophysical model for its reported common-spectrum process, over the curvature-induced background. On the other hand, the two interpretations fit the NANOgrav 12.5 years dataset equally well. We then set new upper limits on the amplitude of the curvature power spectrum at small scales. These are independent from, and competitive with, indirect astrophysical bounds from the abundance of PBH dark matter. Upcoming PTA data releases will provide the strongest probe of the curvature power spectrum around the QCD epoch.

Topic: Cosmology and Gravitation Theories
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Immunohistochemical, Ultrastructural, and Molecular Features of Kindler Syndrome Distinguish It From Dystrophic Epidermolysis Bullosa

These results suggest that the bullous component of Kindler syndrome is distinct from dystrophic epidermolysis bullosa caused by mutations in the type VII collagen gene. Additionally, the differential distribution patterns of uncein and laminin 5 in the patients' skin samples support the hypothesis that uncein and laminin 5 are different molecules.

Topic: Skin and Cellular Biology Research
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Abstract 1230: Critical role of cav1 in high-throughput identification of gallic acid as a novel late-stage autophagy suppresser against invasive breast cancer

Abstract Purpose: Development of autophagy inhibitors has important clinical significance in cancer therapies. We and others demonstrated that over-expression of Caveolin-1 (Cav1), which was the major scaffolding protein of caveolae, was associated with higher tumor stage, metastasis and worse prognosis in various carcinomas, particularly in breast cancer. Furthermore, we identified critical role of Cav1 in breast cancer metastasis via modulation of lysosomal function and autophagy. Based on the above, we screened a series of 2, 645 kinds of small-molecule drugs to find out certain cav1 inhibitors which could suppress autophagy and breast cancer metastasis. Experimental Design: We conducted the 1st high-throughput screening based on surface plasmon resonance (SPR) analysis of cav-1 interaction with 2, 645 kinds of small-molecule drugs. Secondly, we launched the 2nd high-throughput screening based on CCK8 analysis to validate the anti-cancer potential of the selected compounds. We also carried out the final high-throughput screening to investigate their autophagic effects with high content image cytometry assay. The anti-cancer and anti-metastasis effects of the final drug candidate was investigated using invasive breast cancer cells MDA-MB-231 and BT-549, and its role on autophagy was further investigated by transfection of mRFP-GFP-LC3 adenoviral vector and western blot analysis of autophagic proteins. Results: 2, 645 kinds of small-molecule drugs were screened based on a series of high-throughput screening. The compound gallic acid was identified as the candidate drug owing to its strong interaction and competitive inhibition with cav1, its potent anti-proliferation potential on both invasive breast cancer cells MDA-MB-231 and BT-549, as well as its potent autophagic inhibition compared with the other 2, 644 drugs. Further experimental validation revealed that gallic acid was a potent late-stage autophagy inhibitor via inhibiting autophagosome-lysosome fusion. Conclusions: Collectively, these results demonstrated that the cav1 inhibitor gallic acid was a novel late-stage autophagy suppressor with potential clinical application for invasive breast cancer therapy. Citation Format: Neng Wang, Fengxue Zhang, Zhiyu Wang, Yifeng Zheng, Shengqi Wang, Bowen Yang. Critical role of cav1 in high-throughput identification of gallic acid as a novel late-stage autophagy suppresser against invasive breast cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1230.

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Swiss National Registry on Catheter Ablation Procedures: Changing Trends over the Last 20 Years

The Swiss Ablation Registry provides a national database for electrophysiologic studies and catheter ablations. We analyzed the database to provide an in-depth look at changing trends over the last 20 years. During the study period a total of 78622 catheter ablations (age 61.0 ± 1.2 years; 63.7% male) were performed in 29 centers. The number of ablations increased by approximately ten-fold in 20 years. Ablation for atrial fibrillation (AF) was the main driver behind this increase, with more than hundred-fold (39.7% of all ablations in 2019). Atrioventricular-nodal-reentrant-tachycardia (AVNRT) and accessory pathways, being the main indications for ablation in 2000 (44.1%/25.1%, respectively), made up of only a small proportion (15.2%/3.5%,) respectively in 2019. Fluoroscopy, ablation, and procedure durations were reduced for all ablations over time. The highest repeat ablations were performed for ventricular tachycardia and AF (24.4%/24.3%). The majority of ablations (63.0%) are currently performed in private hospitals and non-university public hospitals whereas university hospitals had dominated (82.4%) at the turn of the century. A pronounced increase in the number of catheter ablations in Switzerland was accompanied by a marked decrease in fluoroscopy, ablation, and procedure durations. We observed a shift toward more complex procedures in older patients with comorbidities.

Topic: Cardiac Arrhythmias and Treatments
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences