jimnoneill/paper-to-field-training huggingface dataset:
The Influence of Investment, Debt, and Dividend Policies on the Stock Return of Shariah Compliant Companies in Indonesia (ISSI)

This study aims to analyze the impact of investment, debt, and dividend policies on the stock return of the companies listed in the Indonesia Sharia Stock Index (ISSI) from 2016 up to 2020. The sample stocks used in this study covers all the shariah compliant companies that were consistently listed during the study period, involving 158 companies with 790 observations. The proxies of stock return are annualized stock return, Sharpe ratio, and Treynor ratio. Investment policy is represented by price earnings ratio (PER), debt policy by debt to asset ratio (DAR), and dividend policy by dividend yield (DY). The generalized method of moment (GMM) is a regression technique that is employed in this study. The regression model should pass the AR(2) and Hansen tests to avoid autocorrelation and validity issues. This study provides important evidence that investment policy positively affects stock return (annualized stock return and Treynor ratio). In contrast, investment policy negatively affects the Sharpe ratio. Furthermore, there is a significant negative relationship between debt policy and the Sharpe ratio. Lastly, dividend policy is reported to significantly influence stock return, positive with Treynor ratio, while negative with stock return (annualized). The study relates its findings to the relevant theories involving the trade-off, signalling, and the bird in the hand theories.

Topic: Financial Analysis and Corporate Governance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
[The role of nitric oxide in ethanol postconditioning induced cardioprotection].

The cardioprotection of ethanol postconditioning may be associated with reducing nitric oxide release, inhibiting the opening of mitochondrial permeability transition pore and decreasing the happening of apoptosis.

Topic: Cardiac Ischemia and Reperfusion
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Design ofOne Rotary-linear Permanent Magnet MotorwithTwo Independently EnergizedThree Phase Windings

Electrical drives employing motorsableto directly managemultiple degrees offreedom mayresult in relevant interest inseveral application fields, e.g.robotics andtooling machines. Inthis paper, anewtypeofrotary- linear permanent magnetmotorwithonemotionoftwo degreesof freedomhas been proposed. Itsmain performance advantage isitscharacteristics ofdecoupling linear androtarymotions comparinganothertypesof rotary-linear motors. Theproposed motorconsists oftwo stator three-phase winding systems separately distributed alongradialand axialaxes.By usingindependently energized three-phase windings, two spacerotating magnetical fields alongaxialaxisandradial axisare achieved, whichareutilised toproduct rotary andlinear motion. One special rotorpermanentmagnetstructure capable ofgenerating oneradial andoneaxial magnetical field hasbeenputforward andanalyzed toproduce enough torque, dragforce anddecouple rotary andlinear motions. Basedon thetheoretical analysis and calculation, an experimental motorhasbeendesigned and itsdesign process hasbeendetailed introduced inthepaper.The validity ofanalysis anddesign technique hasbeenconfirmed by one three-dimension finite elementmethod(FEM) calculation.

Topic: Electric Motor Design and Analysis
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Induction of the RelB NF-κB Subunit by the Cytomegalovirus IE1 Protein Is Mediated via Jun Kinase and c-Jun/Fra-2 AP-1 Complexes

ABSTRACT We recently demonstrated that the cytomegalovirus (CMV) immediate-early 1 (IE1) protein induces transcription of the gene encoding the RelB NF-κB subunit. The mechanism of this activation has been explored here. We report that the induction of the relB promoter by IE1 protein is mediated via activation of JNK and AP-1. The region controlling relB promoter induction was mapped to the upstream ∼600-bp region between −1694 and −1096 bp. IE1 stimulated AP-1 activity in NIH 3T3 cells. Competition electrophoretic mobility shift assay (EMSA) confirmed the presence of one bona fide AP-1 element centered at −1503 bp. Introduction of a G-to-C mutation in the AP-1 binding site within the distal region of the relB promoter eliminated its activation by IE1 in both NIH 3T3 fibroblasts and vascular smooth muscle cells (SMCs). Supershift EMSA identified c-Jun, Fra-2, and c-Fos in AP-1 binding complexes in IE1 transfected NIH 3T3 cells. IE1 induced c-Jun phosphorylation, and treatment with SP600125, a selective JNK inhibitor, as well as overexpression of JNK-binding domain of JIP1, blocked IE1-mediated induction of AP-1 and relB promoter activity in NIH 3T3 cells and SMCs. Ectopic expression of c-Jun plus Fra-2, but not c-Fos, induced relB promoter activity. The relB promoter has two proximal NF-κB elements, and c-Jun/Fra-2 worked in synergy with p50/p65 NF-κB complexes. Overall, these findings demonstrate for the first time the role of AP-1 in transcriptional regulation of a gene encoding an NF-κB subunit, and its involvement in induction of RelB activity by the CMV IE1 protein.

Topic: Cytomegalovirus and herpesvirus research
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Antibacterial effect of guava leaves extract mouthwash versus chlorhexidine mouthwash in high caries risk patients: A randomized clinical trial

Aim: To evaluate the effect of guava leaves extract mouthwash on antibacterial activity against streptococcus mutans, salivary pH, and patient satisfaction to taste compared with chlorhexidine mouthwash in high caries risk patients. Materials and Methods: Eighty participants were randomly allocated into two groups based on the mouthwash used: A1 (guava leaves extract) and A2 (Chlorhexidine). The participants were instructed to use the mouthwash once a day for one week and then repeatedly on a monthly basis for three months. Bacterial count, salivary pH, and patient satisfaction to taste were assessed after one week, one month, and three months. Statistical analysis of data using MedCalc software was performed for normality by using Kolmogrov-Smirnov test and Shapiro-Wilk test. Repeated-measures ANOVA and two-way ANOVA were used to assess the interaction of variables for intragroup comparison, and the significance level was set at P ≤ 0.05. Results: By taking into consideration the bacterial count, both mouthwashes showed significant antibacterial effects. However, no statistically significant difference was found between them against the streptococcus mutans during the follow-up periods: one week, one month, and three months, respectively (P = 0.3568, P = 0.0673, and P = 0.0601). Regarding the salivary pH, no statistically significant difference was found between the tested groups during the follow-up periods. Regarding the taste, no statistically significant difference between both mouthwashes was found (P = 0.4254). However, Chlorhexidine showed a statistically significant taste alteration (P < 0.0001) and prolonged taste in the mouth (P = 0.0001). Conclusion: Guava leaves extract mouthwash exhibits promising antibacterial activity without causing taste disturbances.

Topic: Psidium guajava Extracts and Applications
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
CCDC 1403689: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Sources of Biblical Exegesis

Edwards biblical exegesis is informed by early modern biblical interpreters of Scripture. This chapter will explore, first, the place of Poole’s Synopsis in the history of biblical exegesis, as well as Edwards’s use of this synoptic Bible commentary in a New England context. Secondly, the nature of Poole’s work, providing various exegetical options, demands that one ask three questions related to Edwards’s use of the Synopsis: First, does Edwards follow specific exegetical interpretations offered by Poole? Second, what is the underlying source of those interpretations as one attempts to discern exegetical trajectories and choices? Thirdly, does an exegetical choice from Poole in one writing contribute interpretatively to other parts of his writings such as his sermon corpus, treatises, and notebooks, including the notebook on Hebrew Idioms?

Topic: Historical and Linguistic Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Steroid Receptors in the Pregnant Uterus*

In this chapter, the author briefly reviews current theories of the mechanism of steroid hormone action. The distribution of estrogen (E) and progesterone (P) receptors in the pregnant uterus, cervix, and placenta is described, followed by a discussion of the changes in E and P receptor concentrations during pregnancy and the initiation of labor. Evidence for the presence of glucocorticoid receptor systems in the uterus and feto-placental unit is described in the context of the possible role of glucocorticoids in the onset of parturition. The hormone-receptor complexes undergo a process termed "activation" that results in an enhanced affinity for chromatin. The binding of the activated receptor to the chromatin leads, through a process that is as yet poorly understood, to the initiation of new nucleic acid and protein synthesis. The methods for measurement and analysis of steroid receptors depend on the reversible binding of radiolabeled ligands to the receptors, with subsequent determination of the macromo-lecular-bound radioactivity.

Topic: Reproductive System and Pregnancy
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Figure S6 from ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

&lt;p&gt;Figure S6. H3K27ac ChIP-seq, input and gene expression of ASPSCR1 and TFE3.&lt;/p&gt;

Topic: Cancer-related gene regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CCDC 1821308: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Basic hydrolysis of glyceryl nitrate esters. III. Trinitroglycerin

Abstract Kinetics of the basic hydrolysis of glyceryl trinitrate (TNG) were investigated in CO 2 ‐free aqueous calcium hydroxide solutions. The hydrolysis reactions were carried out in a temperature controlled reactor vessel with provision for continuous N 2 sparging of the reaction mixture. TNG hydrolyzed via second‐order reaction at 25°C, 18°C, and 10°C. The activation energy of the hydrolysis reaction of TNG was calculated from the kinetic data and found to be equal to 27.53 kcal/mol. The major products of the hydrolysis of TNG in solution of calcium hydroxide were calcium nitrate and calcium nitrite, accounting for approximately 50% of the degradation products. The minor identified products such as calcium oxalate and nitrate esters amounted to approximatey 6% of the products. The remaining 30% of the isolated products was a mixture of calcium formate, a nitrate ester, and unidentified volatiles, polymerlike substances, and other organic residue.

Topic: Chemical Reactions and Mechanisms
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
An Action Research on Blended Learning Model Applied to the Course Teaching

In the context of higher education, blended learning has been extensively applied in course teaching. This paper employed an action research design, aimed at addressing the practical challenge of how to effectively integrate blended learning into the course teaching to cater to diverse learning preferences, ensure access to a wide range of learning materials, and cultivate practical skills relevant to future roles as professional preschool teachers. This action research involved 62 college students as participants, and conducted two surveys and one focus group interview for data collection. Based on the students' feedback and the researchers' self-reflection, the blended teaching model was modified in order to maximize its benefits for the learners. The modified course teaching model is comprised of before-class stage, in-class stage and after-class stage. Teachers and students shoulder different responsibilities in teaching and learning on each stage, but keep close collaboration during the entire process. Technical support is the key to realization of effective blended learning of this course. Implications and recommendations for future research were also discussed based on the results of this action research.

Topic: Online and Blended Learning
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8<sup>+</sup>T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection

ABSTRACT The intestinal tract is a lymphocyte-rich site that undergoes severe depletion of memory CD4 + T cells within days of simian immunodeficiency virus or human immunodeficiency virus type 1 (HIV-1) infection. An ensuing influx of virus-specific CD8 + T cells, which persist throughout the chronic phase of infection, has also been documented in the gastrointestinal tract. However, little is known of the functionality of these effector cells or their relationship to the disease course. In this study, we measured CD8 + T-cell responses to HIV-1 peptides in paired rectal and blood samples from chronically infected patients. In both blood and rectum, there was an immunodominant CD8 + T-cell response to HIV Gag compared to Pol and Env ( P &lt; 0.01). In contrast, cytomegalovirus pp65 peptides elicited gamma interferon (IFN-γ) secretion strongly in peripheral blood mononuclear cells (PBMC) but weakly in rectal CD8 + T cells ( P = 0.015). Upon stimulation with HIV peptides, CD8 + T cells from both sites were capable of mounting complex responses including degranulation (CD107 expression) and IFN-γ and tumor necrosis factor alpha (TNF-α) production. In rectal tissue, CD107 release was frequently coupled with production of IFN-γ or TNF-α. In patients not on antiretroviral therapy, the magnitude of Gag-specific responses, as a percentage of CD8 + T cells, was greater in the rectal mucosa than in PBMC ( P = 0.054); however, the breakdown of responding cells into specific functional categories was similar in both sites. These findings demonstrate that rectal CD8 + T cells are capable of robust and varied HIV-1-specific responses and therefore likely play an active role in eliminating infected cells during chronic infection.

Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
ChebNet-based Online Health Monitoring for Diesel Propulsion System

As an important means of marine traffic, the safety of ships has always been the focus of attention. The structure of the ship is complex and it is composed of multiple subsystems. The problems of each subsystem will affect the ship's normal operation, and even lead to serious consequences. Therefore, it is an important task to carry out health monitoring on the main subsystems or main components of the ship, which helps to alarm in time when problems happen. This paper takes the intake and exhaust system of the ship propulsion system as an example, sorts out the data collected by multiple sets of sensors arranged on the system, such as temperature and pressure difference, and excavates the correlation between the data to build the graph, and then uses the graph convolutional neural network to process it efficiently to complete the task of predicting the change trend of the data. When the data's change trend is abnormal, the system will be checked or maintained in time to prevent accidents and achieve the goal of health monitoring. In this paper, three different graph convolutional neural networks are used to predict the graph. After comparison, a method that is most suitable for this data set is obtained. It shows high efficiency and good accuracy in the prediction task. It plays an important role in monitoring the health status of the intake and exhaust system of the ship propulsion system.

Topic: IoT and GPS-based Vehicle Safety Systems
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy

Abstract Herein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The biomedical application of DNA nanostructures is highly promising but still in its infancy. DNA nanostructures as drug delivery vehicles are conventionally synthesized in a magnesium-containing buffer. We propose using an anticancer drug to assemble DNA nanostructures and deliver them with siRNA for synergistic anticancer therapy. The metformin cargo induces DNA self-assembly into well-defined, uniform nanostructures, producing a drug–DNA nanocomplex with multiple functionalities for cancer therapy. Both tile-based and DNA origami structures can be assembled with metformin. The as-prepared metformin/DNA nanocomplex showed high structural and thermal stability and enzymatic resistance in physiological settings. The metformin in the nanocomplex and the KRAS G12C siRNA exerted a strong, synergistic antitumor effect against KRAS-mutated non-small cell lung cancer (NSCLC) both in vitro and in vivo by suppressing the RAS/AKT/mTOR and AMPK/AKT/mTOR signaling pathways. The current study suggests that the assembly of complex DNA nanomaterials with carefully chosen small molecules is key to endowing DNA nanostructures with new functionalities and subsequently expanding their applications in multidisciplinary research fields.

Topic: Advanced biosensing and bioanalysis techniques
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Computerized tomography of children with seizure disorders.

During the study period, 49 infants and children had computerized tomography performed on them out of which 19 had CT done for recurrent seizures. They ranged in age from 4 months to 16 years with 13 of them being boys. Generalized tonic--clonic seizures was the most predominant seizure type, being present in 10 of the 19 (52.6%) children while simple partial seizure, myoclonic jerk and mixed seizure types were present in 2 cases each. Abnormal scan was demonstrated in 10 of the 19 children (52.6%) with 3 of them having double cerebral lesions, giving a total of 13 cerebral lesion demonstrated by the CT scan. Cerebral infarct was the most common lesion demonstrated, being present in 5 of the 13 lesions (38.5%). Others were cerebral atrophy in 4 cases (30.8%), moderate ventricular dilatation 2 (15.4%) and 1 each ofporencephalic cyst, hydrocephalus and linear skull fracture. Of the 10 children with abnormal scan, 90% of them had significant past medical history, with birth asphyxia (44.4%) and meningitis (33.3%) being the commonest significant past medical history in them. CCONCLUSION There is a high incidence of abnormal scan findings in children with seizure disorder in our environment compared to what is obtained from the developed countries. Cerebral infarct appears to be the most common abnormal CT findings in our children with seizures.

Topic: Neonatal and fetal brain pathology
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Plasma protein alterations in cattle suffering from acute peritonitis.

Modification of the normal plasma protein picture has been studied in plasma samples from cows suffering from spontaneously arisen (17 cases) or experimentally induced acute peritonitis (5 cases) using polyacrylamide electrophoresis. Considerable differences were found in the postalbumin region during peritonitis. One protein component increased in size, while another disappeared. Two weak components in normal samples were replaced by four discrete protein bands. These modifications were not detected in any of 10 plasma samples from cows suffering from other diseases than peritonitis or in any of 35 samples from clinically healthy animals. The modifications were visible 12-16 h after injection of the provoking agent and were remarkably alike from one case to the next.

Topic: Animal health and immunology
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Study of PVC Plasticized by Octodecyl Acyl Tributyl Citrate

The PVC composite was prepared by extrusion melt using a new plasticizer octodecyl acyl tributyl citrate and PVC resin. Influence on mechanical and resistance to cold properties of PVC was studied by tensile and low temperature impact tests. The thermal behavior, texture and mechanism of plasticizing of OTBC plastifying PVC were supported by TG, DSC and SEM. The result indicated that the glass transition temperature of plastifying material was about 36°C, breaking strength was 25.3MPa, elongation at break was 250% and, plasicizing efficiency was 0.88, resistance to cold property better than plastifying material of DOP’s, domains between two phases of micro-texture were small and distributed homogeneously when OTBC content in PVC resin was 30%.

Topic: Polymer Science and PVC
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Youth and Disaster Management in Malaysia

Introduction: Malaysia is facing increasing exposure to disaster risk. In the last two decades from 1998 until 2019, Malaysia also has experienced 51 natural disaster events, with 281 deaths, over 3 million people affected, and damages worth nearly US$2 billion (MYR8 billion). Thus, disaster management has become a significant concern of the Malaysian government. Two examples of environmental disasters in Malaysia have been discussed. Objective: The objective of this paper is to highlight the importance of youth involvement in disaster risk management, identify strategies to effectively involve them in disaster risk management as well as the describe the current roles of the Malaysian youth in disaster risk management. Method: This review was carried out using secondary data collected from multiple sources on the topic roles of youth in disaster preparedness, risk reduction, and management from the year of 2008-2018. Result: With the considerable youth population in Malaysia, youths of today must be empowered with the knowledge needed to cope with the adverse effects of natural disasters. Furthermore, they are physically strong, mentally agile, and look for change and dynamism in their own lives and their communities. They also embody power and strength, are idealistic, and accept new ideas and views without much hesitation. Therefore, youth could play an essential role in disaster risk reduction and management to decrease the number of victims and casualties. Conclusion: Youth are the best people to participate in disaster management issues because they are invaluable human resources of every nation.

Topic: Disaster Management and Resilience
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences