jimnoneill/paper-to-field-training huggingface dataset:
Data from &lt;i&gt;In Situ&lt;/i&gt; Vaccination with &lt;i&gt;CD204&lt;/i&gt; Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer

&lt;div&gt;Abstract&lt;p&gt;Given the complexity of prostate cancer progression and metastasis, multimodalities that target different aspects of tumor biology, for example, radiotherapy in conjunction with immunotherapy, may provide the best opportunities for promoting clinical benefits in patients with high-risk localized prostate cancer. Here, we show that intratumoral administration of unmodified dendritic cells (DC) failed to synergize with fractionated radiotherapy. However, ionizing radiation combined with &lt;i&gt;in situ&lt;/i&gt; vaccination with DCs, in which the immunosuppressive scavenger receptor A (SRA/CD204) has been downregulated by lentivirus-mediated gene silencing, profoundly suppressed the growth of two mouse prostate cancers (e.g., RM1 and TRAMP-C2) and prolonged the lifespan of tumor-bearing animals. Treatment of subcutaneous tumors with this novel combinatorial radioimmunotherapeutic regimen resulted in a significant reduction in distant experimental metastases. &lt;i&gt;SRA/CD204&lt;/i&gt;-silenced DCs were highly efficient in generating antigen or tumor-specific T cells with increased effector functions (e.g., cytokine production and tumoricidal activity). &lt;i&gt;SRA/CD204&lt;/i&gt; silencing-enhanced tumor cell death was associated with elevated IFN-γ levels in tumor tissue and increased tumor-infiltrating CD8&lt;sup&gt;+&lt;/sup&gt; cells. IFN-γ neutralization or depletion of CD8&lt;sup&gt;+&lt;/sup&gt; cells abrogated the SRA/CD204 downregulation-promoted antitumor efficacy, indicating a critical role of IFN-γ–producing CD8&lt;sup&gt;+&lt;/sup&gt; T cells. Therefore, blocking SRA/CD204 activity significantly enhances the therapeutic potency of local radiotherapy combined with &lt;i&gt;in situ&lt;/i&gt; DC vaccination by promoting a robust systemic antitumor immunity. Further studies are warranted to test this novel combinatorial approach for translating into improved clinical outcomes in patients with prostate cancer. &lt;i&gt;Mol Cancer Ther; 11(11); 2331–41. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: Immunotherapy and Immune Responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Influence of arteriotomy shape on power losses across in vitro cavopulmonary connections.

Surgical junctions including an oval excision within the pulmonary artery may reduce power losses across cavopulmonary connections if compared to simple slot-shaped incisions. These findings may have some influence on surgical techniques to improve hemodynamics of cavopulmonary connections.

Topic: Congenital Heart Disease Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
A CONTROLLED TRIAL OF ANTICOAGULANTS IN CADAVERIC RENAL TRANSPLANTATION

SUMMARY A controlled trial of 6 months of treatment with warfarin was performed in 59 recipients of cadaveric renal transplants. Twenty-nine patients were allocated the drug and 30 acted as controls. Nineteen of the warfarin group and 20 of the control group had functioning grafts at the end of the trial. Because of complications and contraindications only 10 patients were still taking the anticoagulants at 6 months. There was no difference in renal function between the treated and control patients. Warfarin is of no value to the recipient of a cadaveric renal transplant.

Topic: Renal and Vascular Pathologies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Feedforward and Recurrent Neural Networks and Genetic Programs for Stock and Time Series Forecasting

Adding recurrence to neural networks improves their time series forecasts. Well chosen inputs such as a window of time-delayed inputs, or intelligently preprocessed inputs, are more important than recurrence. Neural networks do well on moderately noisy and chaotic time series, such as sunspot data. A single neural network or genetic program generalizes poorly on weekly stock market indices due to the low signal-to-noise ratio. When the responses of a number of networks are averaged, the resulting forecast shows substantial profits on historical data.

Topic: Neural Networks and Applications
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
A Lagrangian study of upwelled waters in the Northern Arafura Sea

Abstract The Arafura Sea is a relatively shallow water basin (less than 200 m) which is subjected to monsoonal winds and affected by the Banda Sea circulation. During the southeast monsoon (May to September) there is evidence of upwelling in this region which is indicated by the cooler SST (Sea Surface Temperature) and elevated chlorophyll concentration, especially at the coast of Papua (northern Arafura Sea). In order to address the origin of the upwelled waters masses, a numerical study using Lagrangian particles was utilized. The model was run backward in time to trace the trajectory of the particles arriving at the northern Arafura Sea, particularly in the upper 50 meters. Each particle was traced backward for three months with the arrival date August 31, 2014, as it is representative for an upwelling month. By this experiment we can identify the origin of the particles on June 1, including their depth, which arrive in the northern Arafura Sea. The daily velocity fields of the 3-D model HAMSOM (HAMburg Shelf Ocean Model) application to the Banda and Arafura Sea for 2014 were used to force the Lagrangian particle-tracking experiment. In general, 76.2% (62%) of particles arriving in 2.5 m (22.5 m) depth, originated from the upper 50 m of the Ceram and Banda Sea. In addition, particles originating from the depth interval 50-100 m contribute 19.6% (26.8%) to the number of particles arriving in 2.5 m (22.5 m) depth. On the other hand, for particles arriving in 47.5 meter depth 46% are originating from the upper 50 m of the southeastern Arafura Sea and 42% from a depth below 100 m of the eastern Banda Sea.

Topic: Oceanographic and Atmospheric Processes
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Acaricidal and Chemical Composition of <i>Allium sativum</i> L. Crude Extracts Against Stored Product Mites <i>Suidasia pontifica</i> Oudemans

(2019). Acaricidal and Chemical Composition of Allium sativum L. Crude Extracts Against Stored Product Mites Suidasia pontifica Oudemans. Journal of Biologically Active Products from Nature: Vol. 9, No. 6, pp. 484-491.

Topic: Insect Pest Control Strategies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Cytokine Serum Levels as Potential Biological Markers for the Psychopathology in Schizophrenia

We discuss the role of immune system disturbance in schizophrenia and especially changes of serum levels of cytokines in patients with schizophrenia. The cytokines are essential to wide range of functions related to the defense of the organisms from infectious and environmental dangers. However it is not known whether cytokines influence the presentation of psychotic symptoms. Identification of changes in the serum level of certain cytokines and their correlation with distinct psychopathological symptoms may facilitate the identification of subgroups of patients who are likely to benefit from immunotherapy or anti-inflammatory therapy. Such patients may benefit from tailored immunotherapy designed for modulation of abnormal cytokine levels related to specific positive or negative symptoms of schizophrenia.

Topic: Tryptophan and brain disorders
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
PRZEFORMUŁOWANIE W PRZYSWAJANIU I UCZENIU SIĘ JĘZYKÓW: SPECYFIKA I FUNKCJE ODTWARZANIA OPOWIADANIA

This article is about a task which required learners to reformulate a story which they had listened to in writing. In the context of foreign language learning, the original text provides a discourse model, whereas the way it is rephrased reflects students’ skill to use the new information in their own words. Retelling can also be treated as language practice focused on learning and practising new vocabulary and sentence structures. The research concentrated on fragments of text that were an extension of the original text that was retold by an elementary group of students of French philology (A2 level according to The Common European Framework of Reference for Languages, 2003) in Polish and French (the foreign language). Comparison of speech produced in the two languages made it possible to consider the nature and function of the learners’ discourse competence which, depending on the students’ personal goals and communicative experience, differed in the two cases. The data collected can serve as a starting point for planning further steps to develop students’ metadiscoursal awareness with the use of the retelling of a story as a learning strategy.

Topic: Linguistic Education and Pedagogy
Subfield: Language and Linguistics
Field: Arts and Humanities
Domain: Social Sciences
Modelling contacts and transitions in the SIR epidemics model

Since the outbreak of the Covid-19 pandemic economists have turned to the SIR model and its subsequent variants for the study of the pandemic's economic impact. But the SIR model is lacking the optimising behaviour of economic models, in which agents can inuence future transitions with their present actions. We borrow ideas and modelling techniques from the Mortensen-Pissarides (1994) search and matching model and show that there is a well-de!ned solution in line with the original claims of Kermack and McKendrick (1927) but in which incentives play a role in determining the transitions. There are also externalities that justify government intervention in the form of imposing more restrictions on actions outside the home than a decentralised equilibrium would yield.

Topic: Economic theories and models
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
A common law fly on the transsystemic wall: observing the integrated method at McGill Faculty of Law

Law schools attempting to prepare students for a more global practice are generally advised to tailor a law curriculum to their individual resources. When offering comparative perspectives, some law school programmes have pedagogical advantages arising out of a mixed legal heritage, such as McGill Faculty of Law’s transsystemic approach. What does the transsystemic approach entail, and can aspects of the transsystemic approach, which is grounded in Québec’s bijural and bilingual context, be practised at national-focus law schools? In order to consider this question, the author observed classroom dynamics in first year transsystemic courses. The McGill experience cannot be imported, but its pedagogy offers key lessons for common law national-focus law schools, including the need to make alternative visions of law necessary for understanding.

Topic: Comparative and International Law Studies
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
A Book Review of <i>Animal Spirits</i>

On balance, this book is right. Much of modern macroeconomics is not very helpful in understanding the behaviour of financial markets and the interaction between the financial sector and the real economy. However, I am not persuaded that injecting the notion of ‘animal spirits’, even in the ways suggested, is going to improve this situation very significantly. Thus, in the last chapter, there is a sustained attack on conventional economic theories via the things they exclude. Such exclusions include changing patterns and modes of doing business; trust and confidence; corruption; stories that interpret the role of the economy. I exclude the sense of fairness from the authors’ list because there are, in fact, numerous conventional economic theories that include this and many other, probably more important, factors which inhibit wage and price flexibility. What is missing from the book is much in the way of advice on how these exclusions can be incorporated into a macroeconomic model which can then be used to answer questions like ‘what should be the capitalisation of banks?’ This is just one from the long list of questions on the penultimate page of the book. It might have been helpful if the authors had selected one of these questions and presented two answers, one taking account of animal spirits, one taking no such account.

Topic: Economic Theory and Policy
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Carbon Fiber Electrode as an Electron Acceptor for a Microbial Fuel Cell Using Geobacter

Microbial fuel cells use bacteria to produce electricity. A dual -chambered microbial fuel cell was used to harness electricity from Geobacter, with carbon fiber as the electrode. The peak current measured was 10.7 μA on the first day, and fell to zero within 5 days. This result is comparable to a similar experiment using the carbon fiber electrode with a different bacteria, but less than typical results from Geobacter when different electrodes were used.

Topic: Microbial Fuel Cells and Bioremediation
Subfield: Environmental Engineering
Field: Environmental Science
Domain: Physical Sciences
Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway

Increased pulmonary vascular permeability is a hallmark of acute lung injury (ALI). Connexin 40 (Cx40) is a gap junctional protein abundantly present in the lung microvascular endothelium. Yet, the role of Cx40 in the regulation of lung vascular permeability and its underlying mechanisms are unclear. Here, we tested the hypothesis that Cx40 participates in regulation of lung endothelial permeability via a mechanism involving a Rho-associated protein kinase (ROCK) dependent regulation of myosin light chain (MLC). In murine models of intratracheal acid- or LPS-induced lung injury, genetic deficiency of Cx40 attenuated key features of ALI including vascular barrier failure. In human pulmonary microvascular endothelial cells (PMVECs), thrombin-induced loss of transendothelial electrical resistance was attenuated by a Cx40-inhibiting mimetic peptide ( 40 GAP 27 ), Cx40-specific shRNA, or ROCK inhibitor Y27632. In isolated perfused mouse lungs, platelet-activating factor-induced lung weight gain was abrogated by gap junction blocker carbenoxolone, 40 GAP 27 , Y27632, or genetic deficiency of Cx40. Phosphorylation of MLC 20 increased drastically in both LPS-treated PMVECs and HCl-treated mouse lungs. Expression of ROCK1 was increased in both LPS-treated PMVECs and HCl-treated mouse lungs, and paralleled by phosphorylation of MLC 20 . Coimmunoprecipitation experiments revealed protein-protein interaction between ROCK1 and Cx40. LPS-induced upregulation of ROCK1 and phosphorylation of MLC 20 were blocked by knockdown of Cx40. LPS caused phosphorylation of myosin phosphatase targeting subunit 1, which could be abrogated by Y27632 or Cx40-shRNA. Our findings reveal a role of Cx40 in regulation of ROCK1 and MLC 20 that contributes critically to lung vascular barrier failure in ALI.

Topic: Connexins and lens biology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
High resolution lightning density maps to study elevation effects at microscale

Lightning location systems have evolved over the years in both location accuracy and detection efficiency. For the Brazilian integrated lightning detection network (RINDAT), the mean location accuracy has increased along the years as the network was expanded and the performance and sensibility were being improved. With the improved location accuracy, accurate and reliable high-resolution lightning distribution maps may be obtained. These maps might then be used to give a better understanding of the lightning distribution and its physical basis. In this paper we analyze the terrain effects in a microscale perspective, using eleven years (1999 to 2009) of data from the RINDAT network to produce the high-resolution maps. These maps are accomplished by a thunderstorm initiation analysis based on the lightning data. The results indicate some interesting elevation effects on the lightning distribution, especially over (isolated) mountains near Sao Paulo and Belo Horizonte and along the coastline of Sao Paulo, which might be related to local storms thermodynamic and/or channel attachment processes.

Topic: Lightning and Electromagnetic Phenomena
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
The athlete–doctor relationship: power, complicity, resistance and accomplices in recycling dominant sporting ideologies

Sociological investigations into the athletemedical practitionerrelationship are scarce due to medical bias for positivist epistemologies.The aim of this research was to identify the scope and purpose ofmedical interventions for four athletes, within the context of socialprocesses that enable medicine to claim athletic bodies as objects ofpractice and performance. The role and function of power in theathletemedical doctor transaction and athlete embodiment were alsoof interest. Using a story-analyst approach grounded in narrativeanalysis, the ideologies of slim to win and performance were identifiedas the impetus for the athletes seeking the expertise of doctors. Doctorswere positioned as accomplices in slim to win and performanceideologies within the athletes stories, which influenced medicalpractices and compromised athlete health. Disciplinary power wasenacted when the doctors observed, corrected and manipulated theathletes bodies through medical practice. Athletes also had agencythrough renegotiating the meaning of the treatment process byreconfiguring medical doctors disciplinary power as forms ofempowerment knowledge. This research highlights the complex natureof the athletemedical doctor transaction and how these encounters canbe productive and oppressive for athletes.

Topic: Sports, Gender, and Society
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Physical object urn:lsid:MfN:Ento:BMT0000016 sampled through event urn:lsid:MfN:Ento:MFNMG001 on 04.08.2022

Physical object urn:lsid:MfN:Ento:BMT0000016 sampled through event urn:lsid:MfN:Ento:MFNMG001 on 04.08.2022

Topic: Erythrocyte Function and Pathophysiology
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Different modalities of host cell death and their impact on <i>Mycobacterium tuberculosis</i> infection

Mycobacterium tuberculosis ( Mtb) is the pathogen that causes tuberculosis (TB), a leading infectious disease of humans worldwide. One of the main histopathological hallmarks of TB is the formation of granulomas comprised of elaborately organized aggregates of immune cells containing the pathogen. Dissemination of Mtb from infected cells in the granulomas due to host and mycobacterial factors induces multiple cell death modalities in infected cells. Based on molecular mechanism, morphological characteristics, and signal dependency, there are two main categories of cell death: programmed and nonprogrammed. Programmed cell death (PCD), such as apoptosis and autophagy, is associated with a protective response to Mtb by keeping the bacteria encased within dead macrophages that can be readily phagocytosed by arriving in uninfected or neighboring cells. In contrast, non-PCD necrotic cell death favors the pathogen, resulting in bacterial release into the extracellular environment. Multiple types of cell death in the PCD category, including pyroptosis, necroptosis, ferroptosis, ETosis, parthanatos, and PANoptosis, may be involved in Mtb infection. Since PCD pathways are essential for host immunity to Mtb, therapeutic compounds targeting cell death signaling pathways have been experimentally tested for TB treatment. This review summarizes different modalities of Mtb-mediated host cell deaths, the molecular mechanisms underpinning host cell death during Mtb infection, and its potential implications for host immunity. In addition, targeting host cell death pathways as potential therapeutic and preventive approaches against Mtb infection is also discussed.

Topic: Tuberculosis Research and Epidemiology
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Azuleno[6,5‐<i>d</i>]isoxazole: Derivate eines neuartigen Ringsystems

Azuleno[6,5‐ d ]isoxazoles: Derivatives of a New Ring System Diazotation of diethyl 2‐amino‐6‐(ethoxycarbonylmethyl)‐1,3‐azulenedicarboxylate ( 2 ) yields azuleno‐isoxazoles 6 and 7 among other products. 9 is another representative of the novel ring system. Reaction paths for the unexpected formation of 6 , 7 , and 9 are scrutinized.

Topic: Synthesis and Reactions of Organic Compounds
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Consultations in Dermatology With Walter B. Shelley, MD, FACP

With Dr. Walter B. Shelley, we are examining and discussing a series of patients, many of interest to the pediatrician. Therapy is included and is in detail. The pediatricians will find little joy in the difficult problem of prepuberty alopecia areata—"remember that for some patients (and mothers?) direct explanation, understanding and reassurance are more than adequate help." References for the disorder of each patient are not just listed, but summarized tersely and well.<i>Consultations in Dermatology</i>are really that—consultations after the pediatrician has used the dermatology section of his own textbook.

Topic: Medicine and Dermatology Studies History
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
PSIM: Periodically Shifted Interleaved Memory System

Interleaved memory schemes have been used to increase the memory bandwidth. In this paper, we propose a new interleaved memory scheme called PSIM (Periodically Shifted Interleaved Memory), which allows high memory bandwidths at the sacrifice of very small memory space. It is a stride dependent scheme where the processor utilization is 100% for most strides using a power-of-two number of memory modules. We show, analytically and then by simulation, that the efficiency of PSIM is consistently higher than not only earlier stride dependent schemes but also stride independent schemes for both short and long vector accesses

Topic: Parallel Computing and Optimization Techniques
Subfield: Hardware and Architecture
Field: Computer Science
Domain: Physical Sciences