jimnoneill/paper-to-field-training huggingface dataset:
Supplemental Figures 1 through 10 from PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability

&lt;p&gt;Supplemental Figure 1. PAX3 Fusion in enhancer chromatin states. Supplemental Figure 2. Integration of Topological Domain Boundaries and RNA Expression Datasets Enable Discovery of Novel PAX3-FOXO1 Target Genes. Supplemental Figure 3. MYC and MYCN Expression, Enhancers and Super Enhancers in RMS Cell Lines and Primary Tumors, compared to Normal Skeletal Muscle and Myogenic Samples. Supplemental Figure 4. Genome-wide binding of PAX3-FOXO1, MYOD, MYOG and MYCN and their Functional Interdependence. Supplemental Figure 5. BRD4 at PAX3-FOXO1 Enhancers Predicts Presence of Looping Machinery and Increased Gene Expression. Supplemental Figure 6. Molecular Sensitivity Landscape of PAX3-FOXO1 RMS cells. Supplemental Figure 7. JQ1 potency across RMS cell lines and xenograft cultures. Supplemental Figure 8. Depletion of BET bromodomains in FP-RMS. Supplemental Figure 9. Impact of JQ1 on PAX3-FOXO1 target genes and PAX3-FOXO1 stability. Supplemental Figure 10. Validation of PAX3-FOXO1 Driven ALK SE Luciferase Contruct and In Vivo Efficacy of JQ1.&lt;/p&gt;

Topic: Protein Degradation and Inhibitors
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supporting Membrane Shape Instability in the Presence of Strongly Adsorbed Flexible Polymers

Strongly adsorbed polymers are shown to undergo an isotropic−nematic surface-ordering transition as a consequence of interactions mediated by the supporting elastic membrane. Depending on the elastic coupling ratio between the membrane and polymer elasticity, the supporting membrane can concurrently undergo a transition into either preferred saddle or tubular shapes. It is argued that this scenario is relevant for the initial stages of the DNA−cationic liposome interactions.

Topic: Lipid Membrane Structure and Behavior
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Atomic displacements and atomic motion induced by electronic excitation in heavy-ion-irradiated amorphous metallic alloys

In amorphous metallic alloys irradiated with swift heavy ions, electronic excitation induces atomic displacements at the beginning of the irradiation and anisotropic growth above an incubation fluence. The authors provide here an extensive review of their data on amorphous Fe85B15 (including work that is already published), as well as a general description of the topic. Samples were irradiated at various temperatures (20 K, 90 K, 223 K) with a large variety of high-energy (GeV) heavy ions (Ar to U). The atomic rearrangements occurring during irradiation were studied by in situ electrical resistance experiments. The influence of the irradiation geometry as well as of a uniaxial stress applied to the sample was investigated. The whole set of data is accounted for with a two-hit phenomenological model allowing one to extract physical parameters. A description of the ion-target interaction on the basis of the Coulomb explosion mechanism is also provided.

Topic: Ion-surface interactions and analysis
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Hydrocephalus: Current State of Diagnostics and Treatment

Hydrocephalus, the accumulation of cerebrospinal fluid in the brain’s ventricles, has numerous difficulties regarding diagnosis, treatment, and patient care. This article provides a comprehensive analysis of the condition, including the areas of current therapeutic options, surgical intervention (implementation of shunts/ third ventriculostomies), and novel therapeutic approaches including inhibition of NKCC1 and modulation of PKC. This paper also discusses noninvasive treatments like gene therapy and “smart shunt” systems. From a global perspective, it is revealed that there are numerous disparities regarding hydrocephalus and its treatment modalities. This very aspect forms the basis for special healthcare programs to cater to these global inequalities. This study bedevils us with the fact of how intricate hydrocephalus management is, a complication that is mostly determined by a specific country’s healthcare infrastructure. The region's funding, health facilities, and cultural issues also are used to showcase hydrocephalus causes and effects. Furthermore, there is a large focus on patient care and also a meticulous presentation of subsequent care strategies and rehabilitation with the family's support to improve the results for those who are afflicted with the disease. This article concludes with a call to go beyond research in this area with the international cooperation that will lead to comprehending this challenge and the multidisciplinary problems and opportunities that come along with it. This research study provides an indispensable contribution to the fields of neurology and healthcare, and this adds value in terms of the care and treatment of hydrocephalus by facilitating its understanding on a scientific basis for students and healthcare professionals around the world.

Topic: Cerebrospinal fluid and hydrocephalus
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Effect of indomethacin on the expression of proteins and sodium channelNav1.3 in the dorsal horn of the spinal cord of rats, induced by anacute peripheral inflamation

In the present study, the expression of proteins and sodium channel
Na1.3, was characterized by electrophoresis in both spinal dorsal horns
(ADM) of rats in control conditions and after an acute unilateral
peripheral inflammation, and treated or not with indomethacin. Sprague
Dawley rats (n=15) were anesthetized (Tiobarbital) and the left hindpaw
was immersed in water at room temperature (26°C) for 60s (control;
n=5); at 60°C (inflamed, n=5) or 60°C pretreated with
indomethacin (pretreated, n=5).After 15 hours, total proteins (Bradford
and electrophoresis) and Nav1.3 channel (Western-blotting)
determinations were performed. Inflammation increased the ADM proteins
ipsilaterally (+39.8%) and reduced it contralaterally (-15%).
Indomethacin decreased expression of proteins in inflammation,
inhibiting those constitutively expressed in the control group and
increasing (+14%) those contralaterally. The channel Nav1.3 was not
expressed after 15 hours of inflammation.The inflammation suppressed
the protein expression in the contralateral ADM.Indomethacin reduced
the ipsilateral protein expression and increased the contralateral.
These results suggest the differential response of each dorsal horn to
noxious stimuli.

Topic: Pregnancy-related medical research
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Sydney : brought to you by world city and cultural industry actor-networks

There have been recent contributions to the world city literature and the new&#13;\neconomic geography literature that have focused on city connectivity and practicebased&#13;\nresearch, through concepts such as city actor-networks, relational&#13;\ngeographies and project-led enquiries. As this literature is developing, this thesis&#13;\naims to analyse and contribute to it by providing an empirical focus in two main&#13;\nthemes that have so far been marginalised in these literatures – the city of Sydney,&#13;\nand the cultural industries. An alternative conceptualisation of world cities, namely&#13;\n‘new urbanism’, which employs Actor-Network Theory, will be utilised in this thesis to&#13;\nask the question, what are the actants of Sydney’s cultural industries (specifically the&#13;\nfilm and TV production industry), and how are they enrolled to create the spacing and&#13;\ntiming of Sydney’s actor-networks? By answering this question, this thesis will&#13;\ncontribute to the knowledge in three ways: theoretically, by adding weight to the&#13;\nalternative concepts of new urbanism and relational economic geographies;&#13;\nempirically, by studying two themes that have been hitherto underdeveloped in the&#13;\nexisting literature; and methodologically, through new developing empirical agendas&#13;\nthat cover the quantification of Sydney’s world city network and ANT-inspired&#13;\nethnographic, ‘project-based’ enquiry.

Topic: Cultural Industries and Urban Development
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
Supplementary Table S3: In vivo potentiation of chemotherapeutic agents from Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment

&lt;p&gt;Supplementary Table 3: In vivo potentiation of chemotherapeutic agents&lt;/p&gt;

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Preparation of Highly Stable and Electrochemically Active Three‐dimensional Interconnected Graphene Frameworks from Jute Sticks

Abstract Over the past few years, the environmentally friendly synthesis of nanomaterials, including graphene using green chemistry, has attracted tremendous attention due to its easy handling, low cost, and biocompatibility. Here we demonstrate a facile and efficient green synthesis route for producing highly stable and electrochemically active three‐dimensional interconnected graphene frameworks (3DIGF) from jute sticks. Initially, jute sticks derived three‐dimensional amorphous activated carbon nanosheets (3DAACNs) were prepared at low temperatures (i. e., 850 °C) in an inert environment. The resultant 3DAACNs were then heat treated at a high temperature (i. e., 2700 °C) under an inert environment, resulting in 3DIGF. The prepared carbonaceous materials were fully characterized, and various experimental techniques confirmed the preparation of 3DIGF. The prepared 3DIGF shows a highly stable nature in thermal and chemical environments and demonstrates a highly dynamic nature for the electrooxidation of sulfide. This study could be considered a vital contribution towards the economic and simple approach for preparing 3DIGF from biomass.

Topic: Supercapacitor Materials and Fabrication
Subfield: Electronic, Optical and Magnetic Materials
Field: Materials Science
Domain: Physical Sciences
Validity of Computer-Controlled Skin Sensation Threshold Measurements and Relationship to Balance in Older People

Falls are an important health issue for older people, as they lead to increased morbidity and mortality and reduced physical function, activities of daily living, and quality of life. Skin sensation is an indicator of the ability to maintain balance, which is a factor in fall risk. We investigated the validity of a computer-controlled plantar-foot sensation-testing instrument (PFS tester) that measures skin sensation. We examined the within-subject reproducibility of skin sensation thresholds and their relationship to balance in older participants. Within-subject skin sensation threshold reproducibility was examined using intraclass correlation coefficients. The skin sensation thresholds showed moderate within-subject reproducibility. The associations between skin sensation thresholds and balance were examined using multiple regression analysis. We found a significant relationship between skin sensation thresholds and balance. The results indicate that the PFS tester is clinically applicable and a reliable indicator of balance ability.

Topic: Balance, Gait, and Falls Prevention
Subfield: Physical Therapy, Sports Therapy and Rehabilitation
Field: Health Professions
Domain: Health Sciences
In vitro micropropagation of rare and endangered moss Entosthodon hungaricus (Funariaceae)

The moss Entosthodon hungaricus (Boros) Loeske is an European endemic species typical of dry and saline soils extending from the Iberian Peninsula to Aral-Caspian steppes, similarly to some other xerothermic bryophytes. However, the distribution range is fragmented and localities are quite scattered and the species is considered as rare and vulnerable because of its ephemeral characteristics and specialized ecology.\nWith the aim to develop an active protection plan for this species, the ex situ conservation requirements of E. hungaricus were developed. The axenic culture in in vitro conditions were established, and the optimal growth parameters were adjusted to achieve fully developed gametophytes ready to be reintroduced to its native range and other potentially native areas, where this species was once reported but has not been collected in recent times, suggesting its local extinction (i.e. some areas in Vojvodina, N. Serbia). Starting materials were derived from recent herbarium specimens and from fresh materials collected from Hungarian populations. Several means for sterilization of stating material and growing nutritive media were assayed in different regimes of light and temperature. \nHere we describe the conditions to achieve full plant development and for its micropropagation. Such materials are adequate for ex situ conservation purposes and for experimental introductions in native and potentially native areas. The first axenical culture of E. hungaricus was successfully established, and the first in vitro micropropagation of this rare and endangered species was achieved. Our study contributes to the conservation biology as well as for the potential use of this moss species in biotechnological research.

Topic: Bryophyte Studies and Records
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Prehospital CPR for Traumatic Arrest: Can Prehospital Variables Help Identify Futile Transport?

Resuscitative efforts (RE) for patients suffering cardiac arrest following trauma require significant prehospital (PH) and hospital resources. Patients who are transported and undergo immediate termination of resuscitative efforts (ITRE) and declared dead on arrival (DOA) may represent a population for whom improved triage can conserve hospital resources. Methods: We sought to identify PH variables associated with DOA/ITRE. 405 trauma patients who had PHCPR from 2014 to 2023 at a Level 1 trauma center were included. Clinical variables analyzed included demographics, mechanism of injury (MOI), PHRE, and hospital RE. The primary outcome of interest was DOA/ITRE. Results: Most patients were male (80.5%), with median age 35, (IQR [25-50]), suffered a penetrating MOI (56.5%), and were severely injured (ISS 34, IQR [25-75]). 102 (25.2%) patients had DOA/ITRE; they tended to be older (41.5 [29-53] vs. 32 [24-47], P = 0.01), were more likely to have a blunt MOIs (52/176 patients (29.6%) vs 50/229 patients (21.8%), P = 0.007), and less likely to have PH interventions (30.3% vs. 69.7%, P = 0.004). When stratified by MOI, patients with penetrating injuries spent a significantly shorter amount of time in the ED (6.3 vs 12.4 min, P &lt;0.001), while in those with blunt injuries did not (10.6 vs 12.5 min, P = 0.3). Discussion: More than 25% of transported patients following traumatic arrest undergo DOA/ITRE. These patients were more likely to have a blunt MOI, older age, and fewer PH interventions. Improved triage of patients in the field may help conserve PH and hospital resources for patients more likely to benefit from transport.

Topic: Cardiac Arrest and Resuscitation
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Attestation Waves: Platform Trust via Remote Power Analysis

Attestation is a strong tool to verify the integrity of an untrusted system. However, in recent years, different attacks have appeared that are able to mislead the attestation process with treacherous practices as memory copy, proxy, and rootkit attacks, just to name a few. A successful attack leads to systems that are considered trusted by a verifier system, while the prover has bypassed the challenge. To mitigate these attacks against attestation methods and protocols, some proposals have considered the use of side-channel information that can be measured externally, as it is the case of electromagnetic (EM) emanation. Nonetheless, these methods require the physical proximity of an external setup to capture the EM radiation. In this paper, we present the possibility of performing attestation by using the side-channel information captured by a sensor or peripheral that lives in the same System-on-Chip (SoC) than the processor system (PS) which executes the operation that we aim to attest, by only sharing the Power Distribution Network (PDN). In our case, an analog-to-digital converter (ADC) that captures the voltage fluctuations at its input terminal while a certain operation is taking place is suitable to characterize itself and to distinguish it from other binaries. The resultant power traces are enough to clearly identify a given operation without the requirement of physical proximity.

Topic: Physical Unclonable Functions (PUFs) and Hardware Security
Subfield: Hardware and Architecture
Field: Computer Science
Domain: Physical Sciences
Railways and commemoration: anniversaries, commemorative cultures and the making of railway history in Britain

Since the nineteenth century, communities connected to the railways industry have and continue to show a strong interest in their history and heritage. While historians of technology and industry are increasingly examining the wider impact of these inventions and innovations, there is room to analyse how the different facets of the railways have impacted social relationships and encounters, and how this self-reflection has been translated into commemorative practice. Examining the different customs and traditions that were created to celebrate railway history, and signalled toward its developments in the present and future, offers a unique insight into how the past has shaped and reshaped the identities of railway communities and the industry more broadly.&#13;\nCommemoration, or the performative use of history and social memory, is the central concept of the thesis. This involves a number of revolving spheres of actions and thoughts that come together to define and shape the functions of these practices. Focussing on this practice as a social phenomenon, this thesis examines the forms and functions of commemorations of the British railway industry from the nineteenth century to the early twenty-first century. &#13;\nTaking examples from a range of communities and geographical locations, it analyses how and why narratives about the history of the industry have been strategically mobilised through commemorative practices, from larger national practices down to the cultures that functioned for smaller communities. These include commemorations by and for railway companies and unions, personal celebrations of friends and colleagues, events organised for enthusiasts and interest groups, commemorative practices about and supported by heritage organisations, and celebrations of symbols of the industry.&#13;\nOverall, this thesis argues that commemoration is an important tool for socialising the narratives and temporality of British railways, and illuminates how and why communities associated with this industry engaged with their shared history.

Topic: Historical and Cultural Archaeology Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Thermal Pits Formed on Si Surfaces by Vacuum Heating

An experimental investigation was made of the formation of thermal pits and hillocks produced on (111) and (100) surfaces of silicon by heating in the temperature range 800°C-1, 300°C in a high vacuum at 3×10-7 Torr and 3×10-8 Torr. It was found that the formation of the thermal pits are caused by preferential thermal etching of surfaces contaminated with initial adsorbates and adsorption of residual gases. Contamination by initial adsorbates was found to form the oriented thermal pits. Residual gases at 3×10-7 Torr were found to form hillocks due to reaction with Si. The presence of β-SiC was always observed on RHEED patterns obtained from surfaces having the thermal pits and hillocks. The effect of thin oxide films on silicon were also investigated. No thermal pits were observed on the surfaces heated with oxide films, even at 3×10-7 Torr.

Topic: Silicon and Solar Cell Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Cooperative Inference with Interleaved Operator Partitioning for CNNs

Deploying deep learning models on Internet of Things (IoT) devices often faces challenges due to limited memory resources and computing capabilities. Cooperative inference is an important method for addressing this issue, requiring the partitioning and distributive deployment of an intelligent model. To perform horizontal partitions, existing cooperative inference methods take either the output channel of operators or the height and width of feature maps as the partition dimensions. In this manner, since the activation of operators is distributed, they have to be concatenated together before being fed to the next operator, which incurs the delay for cooperative inference. In this paper, we propose the Interleaved Operator Partitioning (IOP) strategy for CNN models. By partitioning an operator based on the output channel dimension and its successive operator based on the input channel dimension, activation concatenation becomes unnecessary, thereby reducing the number of communication connections, which consequently reduces cooperative inference de-lay. Based on IOP, we further present a model segmentation algorithm for minimizing cooperative inference time, which greedily selects operators for IOP pairing based on the inference delay benefit harvested. Experimental results demonstrate that compared with the state-of-the-art partition approaches used in CoEdge, the IOP strategy achieves 6.39% ~ 16.83% faster acceleration and reduces peak memory footprint by 21.22% ~ 49.98% for three classical image classification models.

Topic: Neural Networks and Applications
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Insulin resistance and carbohydrate oxidation in patients with chemical diabetes.

In six patients with chemical diabetes, insulin resistance was assessed by the steady-state plasma glucose (SSPG) level during a constant infusion of epinephrine, propranolol, glucose and insulin. During the infusion, the patients had elevated SSPG levels (174 +/- 20 mg/100 ml), compared with six control subjects (96 +/- 3 mg/100 ml, p less than 0.005), demonstrating increased insulin resistance. However, during the infusion, the rate of carbohydrate oxidation was similar in both groups. These results suggest that when insulinemia is controlled, the plasma glucose concentration in chemical diabetics during glucose infusion reaches hyperglycemic levels allowing normalisation of carbohydrate oxidation. Hyperglycemia can thus be considered to be a regulatory mechanism favouring glucose uptake and oxidation in patients with chemical diabetes.

Topic: Metabolism, Diabetes, and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences