jimnoneill/paper-to-field-training huggingface dataset:
Data from Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade

&lt;div&gt;Abstract&lt;p&gt;Abnormal lipid metabolism is a hallmark of tumorigenesis. Accumulating evidence demonstrates that fatty acid synthase (&lt;i&gt;FAS&lt;/i&gt;, &lt;i&gt;FASN&lt;/i&gt;) is a metabolic oncogene that supports the growth and survival of tumor cells and is highly expressed in many cancers. Here, we report that the oncoprotein, hepatitis B X-interacting protein (HBXIP, LAMTOR5) contributes to abnormal lipid metabolism. We show that high expression of HBXIP in 236 breast cancer patients was significantly associated with decreased overall survival and progression-free survival. Interestingly, the expression of HBXIP was positively related to that of FAS in clinical breast cancer tissues, and HBXIP overexpression in breast cancer cells resulted in FAS upregulation. Mechanistically, HBXIP upregulated SREBP-1c (SREBF1), which activates the transcription of FAS, by directly interacting with and coactivating nuclear receptor (NR) liver X receptors (LXR). Physiologically, LXRs are activated via a coactivator containing NR motif in a ligand-dependent manner. However, in breast cancer cells, HBXIP containing the corepressor/nuclear receptor motif with special flanking sequence could coactivate LXRs independent of ligand. Moreover, overexpressed SREBP-1c was able to activate the transcription of HBXIP, forming a positive-feedback loop. Functionally, HBXIP enhanced lipogenesis, resulting in the growth of breast cancer cells &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Thus, we conclude that the oncoprotein HBXIP contributes to the abnormal lipid metabolism in breast cancer through LXRs/SREBP-1c/FAS signaling, providing new insights into the mechanisms by which cancer cells reprogram lipid metabolism in their favor. &lt;i&gt;Cancer Res; 76(16); 4696–707. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
PHYSIOLOGY, MOLECULAR BIOLOGY AND THERAPEUTIC POTENTIAL OF THE THYMIC PEPTIDE THYMULIN

Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.

Topic: Neuroendocrine regulation and behavior
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Comparative Analysis of Topical Evolution Patterns and Temporal Trends of Hypertension Research

Exploring the topical evolution patterns and temporal trends of hypertension can promote knowledge communication among experts, and is of great significance to understand the profile and frontiers of chronic disease. Current popular topic detection mainly focuses on two directions: one is based on social network analysis (SNA), the other is based on the topic models. Aiming at distinguishing their similarities and differences, this paper adopts the community detection method and expanded topic model Dirichlet-multinomial regression (DMR) respectively to detect the topic distribution and evolution trends of hypertension research. A total of 26,717 articles in the PubMed database were used as examples to construct the MeSH Terms co-occurrence matrix. It is found that hypertension literature is mainly concentrated on three communities and five research topics. MeSH Terms obtained from SNA are more specific and clearer, while the DMR has an advantage in exploring the evolution patterns of various themes.

Topic: Bioinformatics and Genomic Networks
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Theoretical Study of Tacticity Effects on Poly(vinyl chloride)/Poly(methyl methacrylate) Miscibility

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Theoretical Study of Tacticity Effects on Poly(vinyl chloride)/Poly(methyl methacrylate) MiscibilityJ. D. HoneycuttCite this: Macromolecules 1994, 27, 19, 5377–5381Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ma00097a018https://doi.org/10.1021/ma00097a018research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Polymer Science and PVC
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Well-being Marketing as Humanistic Marketing

Well-being marketing refers to the business mechanism that plans, prices, promotes, and distributes consumer goods for the purpose of enhancing customer well-being (i.e., marketing beneficence) while preserving the well-being of all other stakeholders (i.e., marketing non-maleficence). As such, well-being marketing has two dimensions: marketing beneficence and marketing non-maleficence. Marketing beneficence refers to marketing decisions (e.g. market selection, product strategy, price strategy, distribu. tion strategy, and promotion strategy) designed to enhance customer well-being. Conversely, marketing non-maleficence alludes to marketing decisions designed to preserve the well-being of other stakeholders . other than customers (e.g., employees, stockholders, distributors, suppliers, local community, and the environment).

Topic: Ethics in Business and Education
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Phenotypic diversity and litter chemistry affect nutrient dynamics during litter decomposition in a two species mix

We have previously demonstrated that the intraspecific diversity of leaf litter can influence ecosystem functioning during litter decomposition in the field. It is unknown whether the effects of phenotypic diversity persist when litter from an additional species is present. We used laboratory microcosms to determine whether the intraspecific diversity effects of turkey oak leaf litter on nutrient dynamics are confounded by the presence of naturally co‐occurring longleaf pine litter. We varied the phenotypic diversity of oak litter (1, 3, and 6 phenotype combinations) in the presence and absence of pine litter and measured fluxes of carbon and nitrogen over a 42‐week period. The average soil C:N ratio peaked at intermediate levels of oak phenotypic diversity and the total amount of dissolved organic carbon leached from microcosms decreased (marginally) with increasing oak phenotypic diversity. The soil carbon content, and the total amount of ammonium, nitrate, and dissolved organic carbon leached from microcosms were all influenced by initial litter chemistry. Our results suggest that the effects of phenotypic diversity can persist in the presence of another species, however specific litter chemistries (condensed and hydrolysable tannins, simple phenolics, C:N ratios) are more important than phenotypic litter diversity to most nutrient fluxes during litter decomposition.

Topic: Ecology and Vegetation Dynamics Studies
Subfield: Nature and Landscape Conservation
Field: Environmental Science
Domain: Physical Sciences
Coping with the Stress of High Stakes Testing

SUMMARY SUMMARY High stakes testing puts considerable pressure on schools, teachers, and students to achieve at high levels. Therefore, how schools and individuals cope with this major source of stress may have important implications for the success of high stakes testing. This article reviews relevant theory and research on stress as they relate to public schools and high stakes testing. Particular attention is given to the negative consequences of stress when the external pressure exceeds the ability of the school or individual to cope with the pressure. The article also reviews strategies that can be used by schools, teachers, and students to cope with stress. Key Words: Stress managementhigh stakes teststest anxietycopingprevention

Topic: Resilience and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Application of Extended Messinger Models to Complex Geometries

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Since, ice accretion can significantly degrade the performance and the stability of an airborne vehicle, it is imperative to be able to model it accurately. While ice accretion studies have been performed on airplane wings and helicopter blades in abundance, there are few that attempt to model the process on more complex geometries such as fuselages. This paper proposes a methodology that extends an existing in-house Extended Messinger solver to complex geometries by introducing the capability to work with unstructured grids and carry out spatial surface streamwise marching.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;For the work presented here commercial solvers such as STAR-CCM+ and ANSYS Fluent are used for the flow field and droplet dispersed phase computations. The ice accretion is carried out using an in-house icing solver called GT-ICE. The predictions by GT-ICE are compared to available experimental data, or to predictions by other solvers such as LEWICE and STAR-CCM+. Three different cases with varying levels of complexity are presented. The first case considered is a commercial transport airfoil, followed by a three-dimensional MS(1)-317 swept wing. Finally, ice accretion calculations performed on a Robin fuselage have been discussed. Good agreement with experimental data, where applicable, is observed. Differences between the ice accretion predictions by different solvers have been discussed.&lt;/div&gt;&lt;/div&gt;

Topic: Icing and De-icing Technologies
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Long Term Effects of Prenatal Docosahexaenoic AcidSupplementation on Early Childhood Growth in Mexico

Background: Long chain polyunsaturated fatty acids
such as docosahexaenoic acid (DHA) have been associated with
improved outcomes during early infancy. Few studies have examined
the longer lasting effects of prenatal DHA supplementation on
growth and development in early childhood. A randomized double
blind placebo controlled trial was conducted in Mexico to ascertain
the effects of prenatal DHA supplementation on childhood outcomes.
At the end of the initial study offspring of supplemented
primagravid women were reported to have larger birth weights and
larger head circumference at birth than offspring of women who
received the placebo. Objective: A further follow up study was
conducted to examine the longer lasting effects of prenatal
supplementation on growth measures of offspring from 18 through 48
months of age. Methods: Pregnant women in Mexico were randomly
assigned to receive either 400mg of algal DHA or a placebo during
week 18 to 20 of gestation through delivery. The children were
followed from 18 months to 48 months and anthropometric data
(height and weight) were collected and analyzed. The main outcomes
in the study included weight (kg), height (cm), body mass index
(BMI), height for age z-scores and weight for height z-scores.
Results: Anthropometric measurements were obtained at 18, 24, 36
and 48 months for 732, 675, 351 and 711 of the 973 children
respectively from the original study. The overall results indicated
that both the intervention and control groups were similar from 18
to 48 months. The results from intention to treat analysis showed
no differences between DHA and placebo. Comparison of average
weight gain per month between 18-48 months revealed that offspring
born to women who received prenatal DHA gained more weight compared
to those born to women who received the placebo, however these
differences were not statistically significant (p>0.05). Mixed
effect regression estimates for the effect of the intervention and
the interaction between treatment and maternal gravidity were not
significant. Conclusion: There were no long term significant
effects of prenatal DHA supplementation on child growth between 18
months to 4 years of age.

Topic: Fatty Acid Research and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Absence of Spasm in a Sensitive Assay for Acetylcholine

Journal Article Absence of Spasm in a Sensitive Assay for Acetylcholine Get access A T Birmingham A T Birmingham Department of Pharmacology, King's College, Strand, London, W.C. 2 Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 13, Issue 1, September 1961, Page 510, https://doi.org/10.1111/j.2042-7158.1961.tb11862.x Published: 12 April 2011 Article history Received: 05 July 1961 Published: 12 April 2011

Topic: Neurological disorders and treatments
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
The Oxford history of Anglicanism, <i>III:</i> Partisan Anglicanism and its global expansion, 1829–<i>c.</i>1914. Edited by Rowan Strong. Pp. xxiv + 490. Oxford–New York: Oxford University Press, 2017. £95. 978 0 19 969970 4

The Oxford history of Anglicanism, III: Partisan Anglicanism and its global expansion, 1829–c.1914. Edited by Rowan Strong. Pp. xxiv + 490. Oxford–New York: Oxford University Press, 2017. £95. 978 0 19 969970 4 - Volume 71 Issue 1

Topic: Reformation and Early Modern Christianity
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
Hennekam Syndrome Presentıng Wıth Abdomınal Mass

We report a patient presenting with an abdominal distention and irritiability, who was found to have Hennekam syndrome. A physical examination revealed left sided hemihypertrophy and a mass with undefined margins around the umblical region. Ultrasonography and contrast enhanced computerised tomography revealed a solid heterogeneous mass extending from the parapancreatic region into the mesenteric root and, diagnostic laparotomy was performed. The intestinal walls and the mesentery were found to be diffusely thickened. Histopathological analysis revealed fibrosis along with cystic enlargement of the lymphatic vessels. The patient had left periorbital edema and facial dysmorphism. Non-pitting edema of the abdomen, left arm, left leg, and left labia majora was noted. Laboratory tests showed hypoproteinemia, hypoalbuminemia, and high faecal α-1 anti trypsin. Endoscopic examination revealed milky fluid oozing from the mucosa into the duodenal lumen. Histopathological analysis revealed total villus atrophy and cryptic hyperplasia. We postulate that an enlargement in the intestinal wall could be mistaken for an abdominal mass, and, we present this case of an abdominal mass as a new manifestation of Hennekam syndrome.

Topic: Gastrointestinal disorders and treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Pathological Phenomena in Denjoy–Carleman Classes

Abstract Let M denote a Denjoy–Carleman class of ∞ functions (for a given logarithmically-convex sequence M = ( M n )). We construct: (1) a function in M ((−1, 1)) that is nowhere in any smaller class; (2) a function on ℝ that is formally M at every point, but not in M (ℝ); (3) (under the assumption of quasianalyticity) a smooth function on ℝ p ( p ≥ 2) that is M on every M curve, but not in M ( ℝ p ).

Topic: Advanced Banach Space Theory
Subfield: Mathematical Physics
Field: Mathematics
Domain: Physical Sciences
Download books to iphone kindle Countdown

Read Or Download Countdown Full Books By Deborah Wiles\n\n\nRead Online =&amp;gt; Read Countdown\n\n\nDownload Book =&amp;gt;&amp;nbsp;Download Countdown\n\n\nCountdown pdf download\nCountdown read online\nCountdown epub\nCountdown vk\nCountdown pdf\nCountdown amazon\nCountdown free download pdf\nCountdown pdf free\nCountdown pdf\nCountdown epub download\nCountdown online\nCountdown epub download\nCountdown epub vk\nCountdown mobi\n\n\n\n#downloadbook #book #readonline #readbookonline #ebookcollection #ebookdownload #pdf #ebook #epub #kindle

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Pregnant Women’s Knowledge about Children Oral Health

Bottle tooth decay is a common problem in dental medicine.Studies point to the relationship between mother's knowledge and motivation to maintain oral hygiene and child's oral health.The reason behind it is that mothers are usually the ones spending most of the time with the child during first years of life.The purpose of this study is to examine the level of pregnant women's knowledge of the importance of primary teeth, caries and its causes, best time to begin tooth brushing and best time for first dental visit.In infant oral health lectures within the pregnancy class, 49 pregnant women were examined.The average age was 31, most of them were educated and employed.Before and after the lecture pregnant women got the same questionnaire and the results of the second questionnaire provides information on the importance of the lecture given within the course of pregnancy.Research results show that pregnant women consider primary teeth very important to childʹs development and general health.Most of them were aware that cleaning childʹs mouth starts even before the first primary tooth appearance and that primary teeth should be restored if necessary.Significant number of respondents knew the exact time of first tooth appearance.Knowledge of the recommended time for first dental visit and the caries risk factors was shown poor.The conclusion is that most pregnant women are unaware that breastfeeding, bottle feeding, using bedtime bottle and frequent feeding cause caries.Lecture on childʹs oral hygiene proved to be extremely useful because for most pregnant women that was the first time, they got that information.

Topic: Dental Health and Care Utilization
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Temperature dependence of optical gain, quantum efficiency, and threshold current in GaAs/GaAlAs graded-index separate-confinement heterostructure single-quantum-well lasers

The temperature dependence of the optical gain in graded-index separate-confinement heterostructure single-quantum-well lasers with different quantum-well widths were investigated. The observed dependence of the kink temperature on cavity loss and quantum-well width and the differential quantum efficiency minimum at the kink temperature were analyzed in terms of the temperature variation of the gain spectra and peak gain curves. Dependences of the characteristic temperature T/sub 0/ on the quantum-well width, cavity loss, and temperature range are discussed in terms of the variation of the peak modal gain versus current relation with temperature and quantum-well width.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Semiconductor Quantum Structures and Devices
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Prevalence of text neck syndrome, its impact on neck dysfunction, and its associated factors among medical students: A cross-sectional study

BACKGROUND: Students increasingly rely on digital devices, leading to text neck syndrome, a common overuse syndrome caused by repetitive forward neck flexion. OBJECTIVE: This study aimed to determine the prevalence of text neck syndrome among medical students and the resulting neck dysfunction and to investigate the possible associated factors. METHODS: This cross-sectional study used an online self-developed questionnaire among medical students. Students’ characteristics and data about smartphone usage were evaluated for diagnosis. Individuals with at least 3 of the 6 text neck syndrome symptoms and a history of more than four hours a day spent on a smartphone were diagnosed with text neck syndrome. Neck dysfunction was measured using the neck disability index. Descriptive statistics and the chi-square test were used. P values &lt; 0.05 were considered statistically significant. RESULTS: The study found that 31.7% of students with text neck syndrome have mild neck disabilities, with a higher proportion of females (40%). The characteristics that have a significant relation to text neck syndrome include being female (p &lt; 0.0001), overweight (p = 0.025), being right-handed (p = 0.001), using four digital devices or more (p = 0.002), having low levels of physical activity (P = 0.018), and spending more than three hours a day sitting down (P = 0.027). CONCLUSION: More than a quarter of medical students had text neck syndrome, and most of them had a mild neck disability. Text Neck Syndrome was linked to an increased number of gadgets used, low exercise, and more time spent in a sitting position.

Topic: Ergonomics and Musculoskeletal Disorders
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences