jimnoneill/paper-to-field-training huggingface dataset:
PO-500 A novel role for junctional adhesion molecule-a (JAM-A) in HER2-positive gastro-oesophageal cancers

Introduction Junctional Adhesion Molecule-A (JAM-A) is a cell-cell adhesion protein that regulates physiological adhesion in epithelial and endothelial cells. Our previous work has shown that increased JAM-A expression on breast tumour epithelial tissue associates with poor prognosis in patients with invasive breast cancer, and identified a correlation between high JAM-A expression and levels of the important oncogene human epidermal growth factor receptor-2 (HER2). An important role for HER2 in gastro-oesophageal cancer is emerging, however the specific role of JAM-A in this setting is unclear. Material and methods In a pilot study, gastric cancer patient tissue sections (n=11) were stained for JAM-A expression. A novel, weighted ranking system was developed to semi-quantitatively score the extremely heterogeneous JAM-A membranous staining in gastric tissues; ultimately ranking tissues as low, moderate or high JAM-A expression. JAM-A scores were also correlated with HER2 status in each section. In parallel, a panel of gastro-oesophageal cell lines was used to investigate potential molecular relationships between JAM-A and HER2. Finally, HER2 protein expression was examined following transient JAM-A gene silencing in the gastro-oesophageal junction cancer cell line ESO26. Results and discussions The pilot study revealed that high JAM-A expression significantly correlated with HER2 positivity, and noted a novel staining pattern for JAM-A in diffuse gastric cancers. Molecular studies showed that JAM-A gene silencing reduced HER2 protein expression in gastric cancer cells. These data suggests that JAM-A may act as a novel upstream regulator of HER2 in gastro-oesophageal cancer cells, and warrant further investigation. Current studies are focussed on elucidating the mechanisms underpinning regulation of HER2 expression by JAM-A. Conclusion Promising preliminary indications that JAM-A plays a role in regulating HER2 expression in non-breast cancers may suggest it as both an unfavourable biomarker, as well as a novel putative pharmacological target for HER2-positive gastro-oesophageal cancers. This abstract has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) under grant number 13/IA/1994 (to AMH).

Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The Opportunity Structure for Discrimination

Gender disparities in wages and attainment caused by employer discrimination can come about by three very different processes: allocative discrimination, within‐job wage discrimination, and valuative discrimination. For the United States, it has been established that within‐job wage discrimination no longer is a major source of wage differences, while valuative discrimination potentially is. Less known is the role of allocative discrimination, especially in the hiring process, which we identify as the point where discrimination is most feasible. Our analysis uses personnel data on all entrants into a large U.S. service organization in the period 1978–86, focusing on managerial, administrative, and professional employees. We study the placement at initial hire and then follow job levels, wages, promotions, as well as departures, in years subsequent to hire.

Topic: Names, Identity, and Discrimination Research
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
The Theory of Planned Behaviour as a predictor of intention to engage in BDSM and vanilla Sex

Abstract The authors postulate that the Theory of Planned Behaviour (TPB) offers a hypothetically valuable framework for investigating Bondage, Discipline, Dominance, Submission and Sadomasochism (BDSM) and non-BDSM sexual behaviours, i.e. “vanilla” sex. This is because it examines attitudes, beliefs, subjective norms, intention, and perceived behavioural control over exhibited behaviours. Online cross-sectional data were gathered from participants classified as “BDSM” (n = 61) and “vanilla” (n = 41). Measures included the Theory of Planned Behaviour Questionnaire (TPB Constructs), as well as Anxiety (GAD–7), Depression (PHQ–9), and Self-Efficacy questionnaires. Findings revealed that the constructs of attitude towards vanilla sex predicts the person’s intention to engage in this behaviour (β = .42, p = .005). Similarly, perceived behavioural control predicts intention to engage in paraphilic or BDSM sex (β = .47, p &lt; .001). This study concludes that the TPB is a useful model for predicting BDSM and vanilla sexual behavioural intention. Future research could uncover additional underlying determining or correlating factors associated with BDSM and vanilla sex, such as mental illness and childhood experiences. Having this understanding of the role that social cognition plays in the development and behaviour of different sexual practices, would benefit the development of sexual wellbeing programmes.

Topic: Sexuality, Behavior, and Technology
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
The genome of <i>Aspergillus niger</i> strain melanoliber

ABSTRACT Aspergillus niger strain melanoliber was isolated from the coastal region of Mumbai, Maharashtra, India. This strain secretes water-soluble melanin attached to peptides possessing metal-chelation properties. Here, we report the whole-genome sequence of Aspergillus niger strain melanoliber. The genome was sequenced using Illumina Novaseq6000 giving a total size of 3.86 Mb.

Topic: melanin and skin pigmentation
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
An Examination of Negotiation Process among ESL Learners in Higher Institution

Negotiation is an integral part of our daily lives. It occurs everywhere and requires skillful interactions. The purpose of this study is to examine the negotiation process among ESL learners and identify any problem that may arise in the process. The participants were twenty-six students who enrolled a course on effective oral communication skills in a public university in Malaysia. The main data were generated from a situational observation of the interactional features produced by the participants who were engaged in the negotiation tasks planned and created by them beforehand. Open-ended questionnaires were also used to capture learners' reflections of the negotiation process. It is found that ESL learners come across major problems, such as loss of words and ideas, and also being overshadowed by proficient learners. The findings of this study contribute to the existing literature on negotiation process by providing insights into the problems faced by the learners while negotiating. These insights are hoped to be useful for teachers in equipping students with necessary language skills for them to manage negotiation process effectively.

Topic: Conflict Management and Negotiation
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
X-ray Hotspot Flares and Implications for Cosmic Ray Acceleration and magnetic field amplification in Supernova Remnants

For more than fifty years, it has been believed that cosmic ray (CR) nuclei are accelerated to high energies in the rapidly expanding shockwaves created by powerful supernova explosions. Yet observational proof of this conjecture is still lacking. Recently, Uchiyama and collaborators reported the detection of small-scale X-ray flares in one such supernova remnant, dubbed “RX J1713-3946 ” (a.k.a. G347.3-0.5), which also emits very energetic, TeV (1012 eV) range, gamma-rays. They contend that the variability of these X-ray “hotspots ” implies that the magnetic field in the remnant is about a hundred times larger than normally assumed; and this, they say, means that the detected TeV range photons were produced in energetic nuclear interactions, providing “a strong argument for acceleration of protons and nuclei to energies of 1 PeV (1015 eV) and beyond in young supernova remnants. &amp;quot; We point out here that the existing multiwavelength data on this object certainly do not support such conclusions. Though intriguing, the small-scale X-ray flares are not the long sought-after “smoking gun ” of nucleonic CR acceleration in SNRs.

Topic: Astrophysics and Cosmic Phenomena
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Harris hawks optimization tuned exponential reaching law based integral SMC for pitch control of linear hydraulic actuated wind turbines

In the present study 5MW NREL horizontal axis wind turbine (HAWT) has been considered for pitch control to reduce fatigue loads and maintain rated power in region III of operation, that is, above rated wind condition. An electrohydraulic linear actuation system has been considered for blade-pitch revolve-motion of the rotor blade, based upon available wind speed. An augmented state improved exponential reaching law integral sliding mode controller (ASIERL-ISMC) has been designed for the HAWT pitch control application. In contrast to the previously reported improved exponential reaching law based controllers, in our ASIERL-ISMC, all state variables and the sliding variable have been considered together to define an augmented reaching law that can enhance the degree of freedom of the controller. Further, hyperparameters of the proposed ASIERL-ISMC have been optimized using Harris hawks optimization (HHO), to achieve superior control performance. The performances of this proposed HHO-ASIERL-ISMC have been compared with existing dynamic exponential term reaching law integral sliding mode controller (DETRL-ISMC) and improved exponential reaching law integral sliding mode controller (IERL-ISMC). The robustness and sensitivity of the proposed ASIERL-ISMC and HHO-ASIERL-ISMC have also been tested with three different available wind data. The proposed HHO-ASIERL-ISMC has been found to provide the most superior performance, in terms of both blade-pitch angle error (computed using integral absolute error (IAE)) and control energy (CE).

Topic: Wind Turbine Control Systems
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Insuring the unknown

Uncertainty is the central element in insurance. This article examines how insurers evaluate and price risks that can present very high levels of uncertainty, and which many underwriters regard as especially hazardous in insurance terms. These are the risks associated with new medical devices, new pharmaceutical products and others substances for human consumption, such as food additives. Insurance is likely to be needed for these products both during their research and development phases, including insurance for clinical trials, and also once the device, drug or other substance gains approval and is in regular use. The article examines the types of insurance that are available to cover these risks, the organizations that provide insurance and how the insurance is organised. It discusses the basic principles that insurers use to price insurance before considering the difficulties presented by novel and complex risks generally. The article concludes with a description of the techniques that insurers employ to analyse and price the particular risks that are our subject and a discussion of how underwriters seek to overcome the special problems associated with them.

Topic: Insurance and Financial Risk Management
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
CCDC 669729: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Axial-vector transitions and strong decays of the baryon antidecuplet in the self-consistent SU(3) chiral quark-soliton model

We investigate the axial-vector transition constants of the baryon antidecuplet to the octet and decuplet within the framework of the self-consistent SU(3) chiral quark-soliton model. Taking into account rotational 1/N_c and linear m_s corrections and using the symmetry-conserving quantization, we calculate the axial-vector transition constants. It is found that the leading-order contributions are generally almost canceled by the rotational 1/N_c corrections. Thus, the m_s corrections turn out to be essential contributions to the axial-vector constants. The decay width of the Theta^+ to NK transition is determined to be Gamma(Theta -&gt; NK)=0.71, MeV, based on the result of the axial-vector transition constant g_A^* (Theta -&gt; NK)=0.05. In addition, other strong decays of the baryon antidecuplet are investigated.

Topic: Quantum Chromodynamics and Particle Interactions
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Corporate Governance and Performance of Deposit Money Banks in Nigeria

This study looks at the relationship between corporate governance and the financial performance of deposit money banks in Nigeria. Ex-post facto resign design was used for the study. The population of this study is all deposit money banks listed on the Nigeria stock exchange as at 31st December 2019. Using judgmental sampling techniques, 10 listed deposit money banks were selected and their annual reports of 10 years (2009 – 2018) were used to collect needed data. Three (3) hypotheses were formulated and tested using multiple regression approach. The findings of the study revealed that board size has a significant positive impact (Î²= 0.006; p &lt; 0.05) on financial performance (measured as ROA) of deposit money banks. Also, board independence has a negative significant effect on financial performance (Î² = -0.010; p &lt; 0.05). While board meeting frequency has no significant influence on financial performance. The study suggests that the CBN policy on board size should be maintained and also recommends that having better level of experience and knowledge in banking and financial matters should be a major consideration in the appointment of non-executive directors.

Topic: Islamic Finance and Banking Studies
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
[Minor malformations and variants of normality at birth. I: Minor craniofacial anomalies].

Authors have studied the presence of minor variant malformations of craniofacial normalities in 189 newborns. Results were grouped according to different anatomical areas where they settled. They have found a greater expressiveness of minor anomalies and, above all, in the auricular external car and, in minor proportion, in the nose and ocular orbs. Results are similar in some cases with the scarce preexistent data, but they differ meaningly with others; maybe that this is produced by the own distinct geographic areas variations.

Topic: Craniofacial Disorders and Treatments
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Preparation and clinical translation of<sup>99m</sup>Tc-PSMA-11 for SPECT imaging of prostate cancer

This study explores the feasibility of radiolabeling the HBED-CC-PSMA (PSMA-11) ligand with Tc-99m for SPECT imaging of prostate cancer patients.

Topic: Radiopharmaceutical Chemistry and Applications
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Role of Speculative Short Sales in Price Formation: The Case of the Weekend Effect

ABSTRACT We argue that short sellers affect prices in a significant and systematic manner. In particular, we contend that speculative short sales contribute to the weekend effect: The inability to trade over the weekend is likely to cause these short sellers to close their speculative positions on Fridays and reestablish new short positions on Mondays causing stock prices to rise on Fridays and fall on Mondays. We find evidence in support of this hypothesis based on a comparison of high short‐interest stocks and low short‐interest stocks, stocks with and without actively traded options, IPOs, zero short‐interest stocks, and highly volatile stocks.

Topic: Financial Markets and Investment Strategies
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
The CSCW analysis method based on fuzzy-timing high-level Petri nets

A method based on fuzzy timing high-level Petri net (FTHN) and workflow technology to model and analyze CSCW (computer supported collaborative works) is presented. Firstly, after introduction of FTHN, how to describe fuzzy timing interdependencies between events of collaboration activities by using FTHN and workflow technology is given. Secondly a set of reference rules and judgment criteria is proposed in order to manage the fuzzy temporal information and verify the temporal logic, especially for the quantitative analysis of CSCW performance. Lastly an example for using this method is illustrated.

Topic: Business Process Modeling and Analysis
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Optimization of Vacuum Drying Characteristics of Date Powder

Kabkab, Khazravi, and Zark are three varieties of Iranian dates representing high, middle, and low sugar content, respectively. Under the vacuum conditions, powders from these dates were produced and placed in the optimized state for the dehydration reaction. The statistical analyses showed that the moisture reduction range of these three varieties at various conditions (100°C and 15.3 cm Hg, 93°C and 30.4 cm Hg, 84°C and 54.6 cm Hg, 68°C and 60.1 cm Hg) were 17.27±0.16, 20.89±0.19, and 7.61±0.02%, respectively. The analysis of variance (ANOVA) on date variety and thickness (0.2, 1, 2, 2.5, and 3 cm) in drying time indicated that the Zark variety with low moisture and sugar contents exhibited the lowest drying time (about 6 h), followed by Khazravi and KabKab. The optimum condition (85°C, 54.6 cm Hg, and 1 cm thickness during 7 h of drying time) was selected for its favorable effects on the moisture reduction, smell/color quality, energy usage, and economical feasibility.

Topic: Date Palm Research Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Strategies and Challenges in Supporting Children with Complex Medical Needs in the Community: Report on a Site Visit to Western Pennsylvania.

complex medical needs were being placed in nursing homes because of home care nursing shortages. As we explored the issue locally, it seemed that framing the issue as a nursing shortage directed solutions that revolved around nursing agency staff recruitment and retention strategies. We wondered about what solutions would be sought if the problem was framed as a permanency issue. Permanency gives primacy to the relationships in a child&amp;apos;s life. Permanency is about filling relational needs. Nursing shortages is about filling shifts. We wanted to explore some different perspectives, so from the Center on Human Policy we put out a call asking for recommendations of places that, on a routine basis, were effectively supporting families with children who have complex medical needs. This report reflects the response to that call and identifies some of our thinking about the issues raised in that response. National Context Since the late 1980s, there has been widespread agreement with the philosophy that &amp;quot;all children belong in families, &amp;quot; and that families should be supported to keep their children at home. The Center on Human Policy published &amp;quot;A Statement in Support of Families

Topic: Child and Adolescent Health
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
GASTRIC VOLVULUS DILATATION SYNDROME IN DOGS

Gastric volvulus dilatation syndrome is a serious condition, of an acute nature, that may lead to a high death rate in small animals.The etiology is unknown, but the literature reports several treatment possibilities.Gastric volvulus dilatation causes a severe decrease in tissue perfusion, affecting several organs, including the respiratory and cardiovascular systems.This study aims to conduct a literature review on the pathophysiology of this syndrome and the therapeutic approach from patient stabilization to surgery treatment.

Topic: Cardiovascular Conditions and Treatments
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Frontispiece: New Phosphorus‐Doped Perovskite Oxide as an Oxygen Reduction Reaction Electrocatalyst in an Alkaline Solution

Oxygen reduction reaction (ORR) plays a pivotal role in alkaline fuel cells and thus, generally determines their performances. In their Full paper on page 6950 ff., W. Zhou, Z. Shao et al. report a novel phosphorus-doped perovskite oxide as an electrocatalyst in an alkaline solution to increase the ORR reaction rate.

Topic: Fuel Cells and Related Materials
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Study of Thawing Characteristics and Mechanism of Frozen Beef in High Voltage Electric Field

The aim is to comprehensively and further explore the thawing characteristics and mechanism of frozen beef in high voltage electric field (HVEF). In this paper, the frozen beef was thawed under blocking ionic wind and changing voltage, electrode distance in the high voltage electric field system. The thawing characteristics, quality parameters and microstructure of beef during thawing were measured. The results showed that compared with the control, high voltage electric field could significantly shorten the thawing time of beef. During the thawing process, the influence of the high voltage electric field in the beef center temperature range from -5 &#x00B0;C to 0 &#x00B0;C on the thawing characteristics is larger than the control. Electrode distance and voltage have significant influence on color, loss rate and quality parameters. The experimental results of blocking ionic wind showed that ionic wind and non-uniform electric field have different effects on the characteristic parameters, quality parameters and microstructure of beef. Both the ionic wind and non-uniform electric field played a significant role in thawing process. This study provides theoretical basis and practical guidance for further understanding of the parameter characteristics and thawing mechanism of high voltage electric field thawing technology.

Topic: Meat and Animal Product Quality
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences