jimnoneill/paper-to-field-training huggingface dataset:
The Impact of Acute Heart Failure on Frailty Degree and Outcomes in Elderly Patients with Severe Aortic Stenosis and Chronic Heart Failure with Preserved Ejection Fraction

Frailty degree plays a critical role in the decision-making and outcomes of elderly patients with severe aortic stenosis (AS). Acute heart failure (AHF) results in a severely worse clinical hemodynamic status in this population. This study aimed to evaluate the impact of AHF on frailty degree and outcomes in older patients referred for tailored interventional treatment due to AS. A total of 109 patients (68% female; mean age 83.3 ± 5.4), evaluated by a multidisciplinary path for “frailty-based management” of valve disease, were divided into two groups, one with (AHF+) and one without AHF (AHF-) and preserved ejection fraction (mean value EF: 57.4 ± 8.6). AHF occurred a mean value of 55 days before geriatric, clinical, and surgical assessment. A follow-up for all-cause mortality and readmission was conducted at 20 months. AHF+ patients showed a higher frequency of advanced frailty (53.3% vs. 46.7%, respectively), rehospitalization (35.5% vs. 12.8; p = 0.007), and death (41.9% vs. 12.8%; p &lt; 0.001). In stepwise logistic regression analysis, AHF emerged as an independent risk factor for advanced frailty (OR: 3.8 CI 1.3–10.7; p = 0.01) and hospital readmission (OR: 3.6 CI 1.1–11.6; p = 0.03). In addition, preceding AHF was an independent determinant associated with a higher risk of mortality (HR 2.65; CI 95% 1.04–6.74; p-value 0.04). AHF is independently associated with advanced frailty and poor outcomes in elderly patients with severe AS. So, this population needs careful clinical and geriatric monitoring and the implementation of interventional therapy for AS in the early stages of frailty to avoid the occurrence of AHF and poor outcomes.

Topic: Frailty in Older Adults
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
S<sub>N</sub>2-Type Nucleophilic Opening of β-Thiolactones (Thietan-2-ones) as a Source of Thioacids for Coupling Reactions

Beta-thiolactones monosubstituted in the 3-position by alkyl and carbamoyl groups undergo nucleophilic ring opening by arenethiolates through a process involving an S(N)2-type attack at the 4-position leading to 3-arylthiopropionates substituted in the 2-position. These thiocarboxylates can be trapped in situ by Mukaiyama's reagent or Sanger's reagent through a nucleophilic aromatic substitution process leading to highly activated thioesters that are then allowed to react further with primary or secondary amines leading, overall, to one-pot, three-component syntheses of 3-arylthiopropionamides carrying various substituents in the 2-position. Alternatively, the trapping combination of an electron deficient aryl halide and an amine may be replaced by a 2,4-dinitrobenzenesulfonamide, resulting in the formation of the same products overall with the incorporation of the latent amine in the sulfonamide into the final amide product. In another embodiment, the thiocarboxylate intermediate is allowed to react with a sulfonyl azide, resulting overall in N-arenesulfonyl 3-arylthiopropionamide derivatives.

Topic: Chemical Synthesis and Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Professional Activity of Disability People in the Central Pomeranian Area

Professional activation is an important part of the economy, in particular local and regional authorities.Properly initiated entrepreneurship significantly affects, among other things, the direct development of the region, including local businesses and the investment opportunities of local government units.Improving competitiveness and the socio-economic image of the region can be seen by taking direct economic initiatives (also in cooperation with economic entities and/or scientific research units) and by implementation of innovation, the use of various forms of external financing, but primarily through new jobs and business activity.The aim of the study is an attempt to present the issue of professional activation of disabled people in the former Central Pomeranian province, in the county Słupsk.The study public opinion poll (own questionnaire study) was conducted at the turn of 2013-2014y.Survey was also conducted in Polish and English literature.In the years 2007-2015 local government organizations implemented 7 projects in the region of Słupsk and also activities are constantly supported by District Labour Office (PUP) activation, which provides services to 97 % of respondents.

Topic: Polish Legal and Social Issues
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Analisis Penerimaan dan Pengeluaran Barang Umum Non Curah Pada Gudang Perbekalan PT. Semen Padang

Inventory has its advantages and disadvantages. The advantage of this inventory is to beable to anticipate the urgent needs of the company, meet the demand from users. But thisstock has a loss, which can increase the costs to be incurred by the company so as to reducethe advantage held by the company. The more the amount of inventory in warehouse, themore the cost of inventory that must be removed and inventory turnover (ITO) whichproduced the lower. One way to do inventory control is to determine the optimal orderquantity. The method used to determine the optimal number of reservations is to use theEOQ method by considering the amount of safety stock and reorder point when done. Basedon the calculations have been performed for the optimal order quantity are 2,019 bottles ofoxygen, welding wirerod is 14,795 stems, and 185 stem of pipe metal. By doing of EOQ toinventory control obtained by the method of ITO increases the weld wire and pipe metalfrom 0.0392 to 1.1010 at the welding wire and from 0.2949 to 0.8627 on a pipe metal.However, the oxygen has decreased from 1.9238 to 1.6094 so that it can be concluded thatthe EOQ method can not be applied to the oxygen, but can be applied to the weldingwire and pipe metal.

Topic: Management and Optimization Techniques
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Testing the gravitational instability hypothesis?

We challenge a widely accepted assumption of observational cosmology: that successful reconstruction of observed galaxy density fields from measured galaxy velocity fields (or vice versa), using the methods of gravitational instability theory, implies that the observed large-scale structures and large-scale flows were produced by the action of gravity. This assumption is false, in that there exist non-gravitational theories that pass the reconstruction tests and gravitational theories with certain forms of biased galaxy formation that fail them. Gravitational instability theory predicts specific correlations between large-scale velocity and mass density fields, but the same correlations arise in any model where (a) structures in the galaxy distribution grow from homogeneous initial conditions in a way that satisfies the continuity equation, and (b) the present-day velocity field is irrotational and proportional to the time-averaged velocity field. We demonstrate these assertions using analytical arguments and N-body simulations of gravitational and non-gravitational models. We also show examples of gravitational and non-gravitational models that {\it fail} reconstruction tests because galaxy formation is modulated (``biased'') in a way that violates the continuity equation. We discuss the relation between the value of $\Omega$ inferred from velocity-density comparisons and the true cosmological value.

Topic: Galaxies: Formation, Evolution, Phenomena
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
[Cardiac deformity and dysfunction in facioscapulohumeral dystrophy--electrocardiogram, ECG gate cardiac MRI studies].

We studied the cardiac deformity and dysfunction in 8 patients with facio-scapulo-humeral (FSH) muscular dystrophy by electrocardiogram (ECG) and ECG gated cardiac magnetic resonance imaging (MRI). Two of the 8 FSH patients revealed elevated P waves and 3 of these patients revealed multifocal atrial premature contractions (APC) on ECG as reported previously. On ECG-gated MRI, the flattened thorax with anteriorly shifted vertebrae restricted the right ventricular movement. On the other hand, the right atrium is often enlarged. It is known that the patients suffering from severe "funnel chest" or "straight back syndrome" often develop similar ECG abnormalities and right atrial dysfunction resulting from restricted right ventricular dilatation. Although a possibility that the abnormal P waves or multifocal APC frequently observed in FSH are caused by myocardial degeneration selectively occurring in right atrium remains to be excluded, the characteristic thoracic deformity may play a primary role in the development of cardiac problems in this hereditary muscular disorder.

Topic: Cardiomyopathy and Myosin Studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Hemodynamic consequences of therapeutic portosystemic shunting: recent experience with transjugular intrahepatic portosystemic shunts.

TIPS provides a side-to-side portosystemic shunt without a major abdominal operation. Although TIPS is relatively less invasive, it is associated with similar hemodynamic alterations as surgically created side-to-side shunts. An important difference is that a mild degree of portal hypertension is maintained with TIPS similar to small diameter shunts. TIPS provides effective portal decompression and prevents variceal hemorrhage. However, the risk of encephalopathy is relatively high and stenosis is a long-term concern in many patients. An important advance in the future use of TIPS will be tailoring the diameter of the shunt to optimize regional and systemic hemodynamics in a given individual to minimize the risk of bleeding or to decrease ascites accumulation while limiting the risk of hepatic encephalopathy and liver failure.

Topic: Liver Disease and Transplantation
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Effect of Phacoemulsification Subtype on the Efficacy of Previously Performed Glaucoma Surgery

Purpose : to compare the efficacy of existing glaucoma surgery after phacoemulsification (PE) and femtosecond PE (femtoPE). Patients and methods . Study included 30 patients (30 eyes) who have undergone a non-penetrative glaucoma surgery with Burrato II cataract. Patients were evenly distributed to the PE and femtoPE groups. Cataract surgery was performed from 3 months to 1 year after glaucoma surgery. Intraocular pressure (IOP) was evaluated before surgery, on week 1, months 1, 3, and 6. Results . Baseline IOP was comparable in both groups: 17,5 ± 1,3 mmHg in a PE group and 17,9 ± 1,5 mmHg in a femtoPE group. In a PE group a statistically significant IOP increase happened on week 1 and month 1, in a femtoPE group it happened only on week 1. In comparison to the femtoPE group, the PE group was associated with bigger IOP increase after 1 week and 1 month (week 1: 17,0 ± 3,6 and 13,2 ± 1,9 mmHg, respectively; month 1: 13,5 ± 2,2 and 13,0 ± 0,7 mmHg, respectively). In months 3 and 6, there was no intergroup difference (12,2 ± 2,1 and 12,5 ± 1,6 mmHg, respectively; 13,3 ± 1,0 and 12,1 ± 1,8 mmHg, respectively). In all follow-up terms amount of hypotensive eyedrops was bigger in the PE group. Conclusion . FemtoPE is safer than PE in eyes with previous glaucoma surgery. Such eyes are more likely to require hypotensive therapy after PE, rather than after femtoPE, for IOP compensation.

Topic: Glaucoma and retinal disorders
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis.

Hyperekplexia is a rare condition characterised by the presence of neonatal hypertonia and an exaggerated startle response. Mutations have been described in GLRA1, the gene encoding the alpha 1 subunit of the glycine receptor, in dominant families with hyperekplexia and in a single sporadic case, thought to represent an autosomal recessive form of the disease. In this study the coding region of the GLRA1 was analysed in eight probands with hyperekplexia by restriction digest and sequencing. Two familial cases were found to possess the previously described G1192A (R271Q) mutation in exon 6. In an additional family in which hyperekplexia cosegregates with spastic paraparesis, a novel A to G transversion at nucleotide 1206 in exon 6 was detected that changes a lysine at amino acid 276 to a glutamate (K276E). In four sporadic cases no mutations were found. In addition, one familial case did not have a mutation in the coding region of the gene.

Topic: Hereditary Neurological Disorders
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
CCDC 946478: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Effect of psychotropic agents upon the blastogenic response of human t-lymphocytes.

Antischizophrenic agents, phenothiazine and nonphenothiazine, inhibit the transformation of the T-lymphocyte in vitro. This inhibition occurs only in the early event and is neither competitive with dopamine, nor appears to involve Na+/K+ adenosine triphosphatase. RNA synthesis is more sensitive to the inhibitory effect than DNA or protein synthesis. This leads to the conclusion that chlorpromazine may act by inhibiting the synthesis of newly formed RNA, and subsequently, transformation, rather than by alteration of the cell membrane.

Topic: Neuroendocrine regulation and behavior
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Elucidation of the Interactions of Reactive Oxygen Species and Antioxidants in Model Membranes Mimicking Cancer Cells and Normal Cells

Photosensitizers (PSs) used in photodynamic therapy (PDT) have been developed to selectively destroy tumor cells. However, PSs recurrently reside on the extracellular matrix or affect normal cells in the vicinity, causing side effects. Additionally, the membrane stability of tumor cells and normal cells in the presence of reactive oxygen species (ROS) has not been studied, and the effects of ROS at the membrane level are unclear. In this work, we elucidate the stabilities of model membranes mimicking tumor cells and normal cells in the presence of ROS. The model membranes are constructed according to the degree of saturation in lipids and the bilayers are prepared either in symmetric or asymmetric form. Interestingly, membranes mimicking normal cells are the most vulnerable to ROS, while membranes mimicking tumor cells remain relatively stable. The instability of normal cell membranes may be one cause of the side effects of PDT. Moreover, we also show that ROS levels are controlled by antioxidants, helping to maintain an appropriate amount of ROS when PDT is applied.

Topic: Nanoplatforms for cancer theranostics
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
The time course of morphological processing in a second language

We report findings from psycholinguistic experiments investigating the detailed timing of processing morphologically complex words by proficient adult second (L2) language learners of English in comparison to adult native (L1) speakers of English. The first study employed the masked priming technique to investigate - ed forms with a group of advanced Arabic-speaking learners of English. The results replicate previously found L1/L2 differences in morphological priming, even though in the present experiment an extra temporal delay was offered after the presentation of the prime words. The second study examined the timing of constraints against inflected forms inside derived words in English using the eye-movement monitoring technique and an additional acceptability judgment task with highly advanced Dutch L2 learners of English in comparison to adult L1 English controls. Whilst offline the L2 learners performed native-like, the eye-movement data showed that their online processing was not affected by the morphological constraint against regular plurals inside derived words in the same way as in native speakers. Taken together, these findings indicate that L2 learners are not just slower than native speakers in processing morphologically complex words, but that the L2 comprehension system employs real-time grammatical analysis (in this case, morphological information) less than the L1 system.

Topic: Second Language Acquisition and Learning
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Effects of <i>Guankou</i> grape polyphenol oxidase on enzymatic browning

Polyphenol oxidase (PPO) was found to be the main cause of Guankou wine browning by investigating the browning index (BI) and the phenolic substances during the winemaking process. PPO was purified via temperature-induced phase partitioning, ammonium sulfate precipitation, and chromatography. The estimated molecular weights obtained by SDS-PAGE were 38 and 45 kDa. PPO was found to have an optimum pH and temperature of 4.6 and 30°C, respectively. The minimum time required to achieve inactivation was 10 min at 75°C. PPO from Guankou grape showed the highest binding affinity with caffeic acid, and a higher affinity for catechin than that from other grape varieties. The addition of ascorbic acid effectively reduced the browning of Guankou wine. Practical applications Guankou grape is the main variety in Jianshi County, Hubei Province, China. The enzymatic browning process of Guankou grapes and PPO characterization after purification were investigated, and it was found that the unique PPO was responsible for the rapid browning of Guankou wine. A suitable inhibitor was also found to prevent that from happening. These results provide a more comprehensive understanding of the features of Guankou grape PPO, and may assist with the effective control of browning occurring during wine making.

Topic: Fermentation and Sensory Analysis
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
LHD nb1pwr_PortThrough #178887.1 (analyzed)

Neutral beam injector (NBI) power-PortThrough of beam line 1 (BL1). The effective power that actually reaches the plasma after the negative ion-based neutral particle beam emitted from the NBI system passes through BL1.

Topic: Grief, Bereavement, and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Development of the Thai Family Support Scale for Elderly Parents (TFSS-EP)

Family is a major resource of support for elderly Thai parents. Although international research has shown several functional aspects of family support, little is known about the functional aspects of family support in the Thai culture. Therefore, the purpose of this study was to develop an instrument for assessing family support for elderly Thai parents. Both quantitative and qualitative approaches were employed in the development and testing of the Thai Family Support Scale for Elderly Parents (TFSS-EP). Items were derived, based on a literature review and interviews with 35 elderly parents, addressing perceptions about types of family support provided by adult children. Factor and item analysis were conducted, with 500 subjects, to determine the structural domains of the instrument. Test-retest reliability of the instrument was determined among 10 elderly parents. Construct validity was determined by comparing differences in the total TFSS-EP's score between two groups of elderly parents (those living with children (n =30) and those living in a shelter home (n = 30)). The final instrument contained 61 items that explored family support. Exploratory factor analysis revealed a 3-factor solution, which accounted for 57.03 % of the total variance. Test-retest reliability was stable, between 2 times among 10 respondents over one week, indicating a high degree of stability for all TFSS items. It was noted that elderly parents, who were living with their adult child, had higher scores on the instrument, compared with those living in a shelter home. Thus, the TFSS-EP appears to be a reliable and valid instrument for measuring family support for elderly Thai parents.

Topic: Intergenerational Family Dynamics and Caregiving
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Prevalence of metabolic alterations predictive of cardiovascular disease risk in the Québec population.

According to our results, only 31% of the Québec population is nonobese without major alterations in their metabolic risk profile. Indeed, 61% of Quebecers are either characterized by chronic diseases or by an altered metabolic profile increasing their risk for the development of CVD and type 2 diabetes. Such a high prevalence should be a source of concern justifying the development of simple screening tools for early identification of the asymptomatic carriers of this cluster of metabolic abnormalities.

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Co zrobić z Tym Wstydem?… Jacek Podsiadło, Słup ze słów i problemy z pamięcią w edukacji polonistycznej

The paper attempts to analyse the concept of memory in the social conscience, which is a taboo (despitefilms, testimones, the amount of academicresearch) related to the participation of the Polish communities in the Holocaust. It is believed that this dark memory or dark post-memory is animportant element which partially creates the sphere of key values for etery community ornation. Its absorption defines the maturity in taking up the challenges of history and indvidual experience. In order to avoid it being only anelitist memory, it should be included in the school practice, which is a difficult endeavour. It is controversial, and sometimes leads to an even stronger denial of knowledge and unwanted experience, due to its disgracefulness. In Jacek Podsiadło’s Słup ze słów, it is possibe to see the chance to break from this oblivion in the Polish Language Education.

Topic: Polish-Jewish Holocaust Memory Studies
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences