jimnoneill/paper-to-field-training huggingface dataset:
Local Renin Angiotensin Expression Regulates Human Mesenchymal Stem Cell Differentiation to Adipocytes

Clinical and experimental evidence suggest that the renin–angiotensin system (RAS) plays a role in metabolic syndrome. Adipogenesis is suggested to modulate obesity and obesity-related consequences, such as metabolic syndrome. Although mesenchymal stem cells (MSCs) are a major source of adipocyte generation, the influence of RAS on MSC differentiation to adipocyte is unknown. We evaluated the expression of endogenous RAS in human MSCs during its differentiation to adipocytes and studied the effects of angiotensin II (Ang II), Ang II type 1 receptor blocker Valsartan, and type 2 (AT 2 ) receptor blocker PD123319. Our data showed that differentiation was associated with an increase in cellular renin and AT 2 receptor expression and a concomitant decrease in angiotensinogen and angiotensin-converting enzyme expression. The net effect is an increase in endogenous cellular angiotensin II production. Incubation with Ang II (exogenous) inhibited adipogenesis. Combined treatment of exogenous Ang II and Valsartan further inhibited adipogenesis, whereas combined treatment of Ang II and PD123319 completely abolished the inhibition of adipogenesis, suggesting an important role for the AT 2 receptor. Blockade of endogenous angiotensin II effect by incubation with Valsartan alone inhibited adipogenesis, whereas PD123319 alone promoted adipogenesis, confirming the data using exogenous Ang II. The combination of Valsartan and PD123319 had no net effect. Our data demonstrate an important role of the expression of the local RAS in the regulation of human MSC differentiation to adipocytes. Elucidation of the molecular mechanism should provide important insight into the pathophysiology of the metabolic syndrome and the development of future therapeutics.

Topic: Cardiovascular Disease and Adiposity
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Pre-hospital management of a multiply injured trauma victim

Abstract During an intensive care medicine attachment you are on a rota shared with the ED to provide a pre-hospital medical team, in response to a request from paramedics on scene for a physician’s attendance. One evening you are tasked for an emergency medical response to a high-speed road traffic collision, in which a car has left a motorway at high speed after aquaplaning and rolled over several times in a field. No specific details have been provided, other than there are multiple severely injured casualties.

Topic: Trauma and Emergency Care Studies
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Results of a national survey ‘It’s time for Lp(a)’ regarding the awareness, attitudes and practices of bulgarian cardiologists for testing lipoprotein(a)

Aim: &amp;ldquo;It&amp;rsquo;s Time for Lp(a)&amp;rdquo; is a survey of Bulgarian Society of Cardiology (BSC) assessing the awareness and use of lipoprotein(a) &amp;ndash; Lp(a), and the challenges that limit this lipid assessment. Methods and results: In the period of July-August 2024, the BSC conducted an on-line national survey with questions in three areas: professional information; information on the clinical circumstances in which cardiologists are considering Lp(a) testing and questions about reasons for limited test recommendation. Of the 585 cardiologists who took part in the survey, 189 answered all of the questions, and 396 answered partially. Only 18% of clinicians declare that they routinely measure Lp(a) primarily for cardiovascular risk stratification and in cases of family history. Additionally, 50% of cardiologists never measure Lp(a) at all. The most&amp;nbsp;common reasons for not referring patients for testing Lp(a), according to 55% of cardiologists, are its absence in standard lipid panel and the fact that the test is not reimbursed (54%). 94% of respondents say that they would use Lp(a) if the test was reimbursed. 48% of cardiologists need clear clinical guidance on the use of Lp(a). According to 64%, the availability of therapies targeting this lipoprotein would lead to a greater use of Lp(a) test. Conclusion: These results indicate the need for further efforts by scientific societies to introduce clear and detailed guidelines, inclusion in lipid panels and reimbursement of testing, as well as educational initiatives to address the limited use and recognition of Lp(a) as a risk factor.

Topic: Lipoproteins and Cardiovascular Health
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
A note on Bridgeland stability conditions and Catalan numbers

In this short note, we describe a problem in algebraic geometry where the solution involves Catalan numbers. More specifically, we consider the derived category of coherent sheaves on an elliptic surface, and the action of its autoequivalence group on its Bridgeland stability manifold. In solving an equation involving this group action, the generating function of Catalan numbers arises, allowing us to use asymptotic estimates of Catalan numbers to arrive at a bound for the solution set.

Topic: Algebraic Geometry and Number Theory
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Two-Dimensional Materials: Doping-Induced Variation, Heterojunction FETs and Hybrid Multilayers

As the size of Complementary Metal Oxide Semiconductor (CMOS) field effect transistor (FET) approaches its fundamental physical limit, two-dimensional (2D) layered structures, such as transitional metal dichalcogenides (TMDs), have been proposed as the alternative channel materials to extend the Moore’s law. In this thesis, we proposed and studied a new set of device structures based on 2D MoS2/WSe2 heterojunction in order to construct the smallest field effect transistor, whereas the switching is achieved via gated heterojunction. Following a step-by-step approach, we have studied the doping effect of different TMDs, formation of heterojunction between different TMDs and gated field effect transistor based on these 2D heterojunctions. During the study of Doping effect on 2D TMDs, we found that random dopant position led to large variation in electronic properties of 2D materials. Therefore, we focus on the study of 2D heterojunction FET instead of the pn-junction. We have studied the formation and transport properties of 2D heterojunctions, with a focus on MoS2/WSe2 heterojunction as it exhibits the best junction characteristics. We then used the MoS2/WSe2 heterojunctions as the channel materials to construct the smallest FET. Such 2D junction-based FETs exhibited very interesting and attractive device characteristics. This study has successfully demonstrated a new set of device structures and materials in order to achieve 2D FET for the extension of CMOS scaling. The results of this thesis may open a suit of new applications in future electronics.

Topic: 2D Materials and Applications
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Treatment of age-related macular degeneration

The pattern of the retinal vasculature is thought to be unique for each eye. In the excellent review article by Mr Browning and co-authors (April 2004 JRSM1) it was therefore interesting to see how this pattern changed after photodynamic therapy (their Figure 3a and b). Verteporfin photodynamic therapy is clearly powerful medicine!

Topic: Retinal Diseases and Treatments
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
The Importance of Well-Seismic Calibration for Interpreting Seismic Inversion Results

A-14 THE IMPORTANCE OF WELL-SEISMIC CALIBRATION FOR INTERPRETING SEISMIC INVERSION RESULTS Abstract 1 Seismic inversion techniques have become an integral part of the reservoir characterisation workflow. The resulting impedance data can provide improved interpretation and quantification of the reservoir rock properties but this depends on the well-seismic calibration. Without a good calibration the inversion results are at best qualitative and at worst can lead to assigning geological meaning to inversion artefacts. We discuss the importance of the well-seismic calibration within the context of the geostatistical inversion method. This method uses 3-D seismic and acoustic impedance (AI) well logs to derive

Topic: Reservoir Engineering and Simulation Methods
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
A case-control study of ulcerative colitis in relation to dietary and other factors in Japan. The Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan.

The etiology of ulcerative colitis is essentially unknown. A hospital-based case-control study examined the risk of ulcerative colitis in relation to dietary and other factors. Recruited at 20 hospitals across the nation were 101 ulcerative colitis patients who were 10-39 years old at the time of disease onset and whose disease had been diagnosed within the past 3 years. One hundred and forty-three control subjects were also examined. Information on factors was obtained by using a self-administered questionnaire. Combined consumption of western foods (bread for breakfast, butter, margarine, cheese, meats, and ham/ sausage) was significantly related to an increased risk of ulcerative colitis (trend P = 0.04). Of the six food items of the western food group, margarine was positively and significantly associated with ulcerative colitis (trend P = 0.005), and bread for breakfast tended to be positively associated with the risk (trend P = 0.07). No appreciable association was found for the consumption of Japanese foods, vegetables and fruits, confectionery, or soft drinks. Compared with lifelong nonsmokers, current smokers had a decreased risk, and former smokers had an increased risk. This study confirmed a protective association between smoking and ulcerative colitis, and suggested that margarine or chemically modified fat may play an etiological role in the development of ulcerative colitis.

Topic: Inflammatory Bowel Disease
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Fully Integrated C-Band GaN MMIC Doherty Power Amplifier With High Efficiency and Compact Size for 5G Application

This paper presents a fully integrated C-band Doherty power amplifier (DPA) based on a 0.25-&#x03BC;m GaN-HEMT process for the 5G massive MIMO application. The performance degradation caused by nonlinear output capacitance is analyzed, and a novel compensation technique is proposed. A low-Q output network is employed to broaden the bandwidth, and its insertion loss in the back-off region is demonstrated to be mainly decided by the Q-factor of the drain bias inductor of the main PA. Hence, by adopting on-chip transmission lines with high Q-factors for drain biasing, a full integration, and a low loss can be achieved simultaneously. Reversed uneven power splitting and back-off input matching are proposed for gain enhancement. The fabricated DPA demonstrates a small-signal gain of 8.6-11.6 dB, an output power of 40.4-41.2 dBm, a 6-dB back-off drain efficiency (DE) of 47% - 50%, and a saturation DE of 55%-63% across a wide bandwidth from 4.5 to 5.2 GHz, with an ultra-compact size of 2.2 mm &#x00D7; 2.1 mm. Using a 40-MHz LTE signal with a 7.7-dB peak-to-average power ratio at the carrier frequency of 4.9 GHz, the measured average output power and efficiency are 33 dBm and 43%, respectively. The raw adjacent channel power ratio is -29 dBc and is improved to -46 dBc by applying digital predistortion.

Topic: Advanced Power Amplifier Design
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
A novel positive inotropic series. 2nd communication: in vivo studies of 5- and 6-pyridyl-2(1H)-quinolone derivatives.

In the anaesthetized rabbits and dogs, the 6-pyridyl compounds 14, 32 and 33 (0.1-3 mg/kg) and the 5-pyridyl compounds 6 and 7 (1-10 mg/kg), administered i.v., produced dose-related increases in cardiac contractile force lasting more than 30 min. They also produced relatively minor and shorter-lasting increases in heart rate. Only the 6-pyridyl series decreased blood pressure. The effects were not blocked by propranolol. In the normal haemodynamic states, myocardial oxygen consumption did not increase. When the haemodynamic characteristics of heart failure were produced by propranolol in anaesthetized rabbits and dogs, compounds 14, 32 and 33 reversed these effects, increasing in particular cardiac output. These studies suggest that compounds of the 6-pyridyl series might be beneficial in patients with congestive heart failure.

Topic: Anesthesia and Sedative Agents
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Ixodid ticks avoid contact with liquid water

ABSTRACT Larvae of the cattle tick Boophilus microplus and all life stages of the European sheep tick Ixodes ricinus avoid walking on a wet membrane surface surrounding a dry patch. Of 170 reactions made at a border with liquid water by 22 B. microplus larvae, 40 % consisted of immediate turns to the opposite side to bring all the legs back onto a dry patch, 41 % were walks along the border, during which the ticks maintained contact with both the dry and wet zones, and 19 % were returns to the dry patch after a short excursion onto the wet surround. Since contact with one front leg tip was sufficient to cause return reactions from the wet surface in most of the border contacts, the water receptor(s) that enable ticks to perceive the wet surface are probably located in terminal pore sensilla on the first-leg tarsi. Observations on the return reactions of ticks with different groups of chemosensilla masked confirmed this. Ticks have an ambiguous relationship with water: they appear to avoid direct contact with it, but they need a high humidity to compensate for any deficit in body water.

Topic: Vector-borne infectious diseases
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Provisional Semantics: Addressing the Challenges of Representing Multiple Perspectives Within Public Collections

This paper presents a reflective account of the AHRC-funded Provisional Semantics project, which focused on how museums and heritage organizations might produce search terms, catalogue entries and interpretation using ethical and equitable practices, particularly in relation to the artworks and histories of racialized and minoritized people, and in the context of a digitized national collection. As the project developed, the emphasis shifted toward a more fundamental enquiry into whether these objectives were achievable, given the structural racism and colonial logics inherent in the museum project and its conventions, histories, and infrastructure. Through a critical discussion of the project’s three case studies, the paper considers the following questions: what happens when we change words and clean data as a putative solution to problematic cataloguing? Can museums genuinely, equitably, and ethically represent multivocality? Why is embedded change in attitudes and behaviors hard to achieve and slow to happen? And is sector guidance for research and documentation fit for purpose in terms of genuine knowledge co-production and engagement?

Topic: Digital and Traditional Archives Management
Subfield: Conservation
Field: Arts and Humanities
Domain: Social Sciences
Selecting for Shame: The Monitoring of Workers’ Rights by the International Labour Organization, 1989 to 2011

Why do intergovernmental organizations target some countries, but not others, for naming and shaming? We seek answers by examining these processes within the International Labour Organization (ILO), which through two principal bodies, monitors compliance with international conventions governing the rights of workers. We examine whether political interests and calculations or norms inducing adherence to international conventions best explain which countries the ILO calls out for their misconduct, what punishment countries receive, and whether naming and shaming in the ILO amount to distinctive activities. Based on an analysis of the 1989–2011 period, we find considerable evidence that norms matter to members of both ILO bodies. That is, we find evidence that the ILO “does its job” by acting in accordance with the organization's formal mandate. We also find evidence that the process of naming, which leads to the initial identification of culprits, stands apart from the process by which the ILO prioritizes, or chooses, from among countries for shaming. While our findings are specific to the ILO, they back claims that IOs can override states interests, if crafted in ways that limit political influence.

Topic: International Labor and Employment Law
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Haptotropic rearrangements in polyene-MLn complexes. 3. Polyene-ML2 systems

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHaptotropic rearrangements in polyene-MLn complexes. 3. Polyene-ML2 systemsJerome Silvestre and Thomas A. AlbrightCite this: J. Am. Chem. Soc. 1985, 107, 24, 6829–6841Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://doi.org/10.1021/ja00310a015RIGHTS & PERMISSIONSArticle Views127Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts

Topic: Molecular Junctions and Nanostructures
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Effect of different tillage methods on growth parameters and economics of pulse crops grown in mechanically harvested lowland rice

A field experiment was conducted during rabi season of 2022-23, at siddapur research farm, Regional Agricultural Research Station (RARS), Warangal, Telangana, India to study the "Effect of different tillage methods on growth parameters and economics of pulse crops grown in mechanically harvested lowland rice". The experiment was laid out in split plot design replicated thrice having three tillage practices (Zero tillage T1: Reduced tillage T2: Minimum tillage T3) in main plots and four rabi pulse crops (Chickpea S1; Greengram S2; Blackgram S3; Cowpea S4) in sub-plots with total twelve treatment combinations. Results of the experiment revealed that economics of pulse crops were influenced by tillage practices, significantly higher gross returns (Rs 184814 ha-1), net returns (Rs 106639 ha-1) and B:C ratio (2.36) was obtained with reduced tillage (T2). Whereas, among sub-plot treatments significantly higher gross returns (Rs 192284 ha-1), net returns (Rs 116067 ha-1) and B:C ratio (2.52) was generated by rice-greengram sequence.

Topic: Rice Cultivation and Yield Improvement
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Medical Evaluations of Healthy Persons

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal

Topic: Healthcare Policy and Management
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Bovine Viral Diarrhea: Prophylaxis and Postvaccinal Reactions

SUMMARY Approximately 10 million doses of attenuated live bovine viral diarrhea ( bvd ) virus vaccines are used annually in the United States. The use of such products has increased steadily since the products were first marketed in 1964. About 60% of the bvd vaccines sales volume is in the form of combination vaccines with either infectious bovine rhinotracheitis virus ( ibr ) or parainfluenza-3 ( pi -3) virus or both. Despite the phenomenon of the postvaccinal syndrome and the stigma attached to it, bvd vaccines today are widely accepted by both the cattle owner and veterinary practitioner. Research workers, however, continue to explore the possibilities of developing practical, safe, and potent inactivated bvd vaccines.

Topic: Viral gastroenteritis research and epidemiology
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences