jimnoneill/paper-to-field-training huggingface dataset:
Daily bone marrow cell transplantations for the management of fast neurodegenerative processes

Cell therapy has been proven to be a promising treatment for fighting neurodegenerative diseases. As neuronal replacement presents undeniable complications, the neuroprotection of live neurons arises as the most suitable therapeutic approach. Accordingly, the earlier the diagnosis and treatment, the better the prognosis. However, these diseases are commonly diagnosed when symptoms have already progressed towards an irreversible degenerative stage. This problem is especially dramatic when neurodegeneration is aggressive and rapidly progresses. One of the most interesting approaches for neuroprotection is the fusion between healthy bone marrow-derived cells and neurons, as the former can provide the latter with regular/protective genes without harming brain parenchyma. So far, this phenomenon has only been identified in Purkinje cells, whose death is the cause of different diseases like cerebellar ataxias. Here we have employed a model of aggressive cerebellar neurodegeneration, the Purkinje Cell Degeneration mouse, to optimize a cell therapy based on bone marrow-derived cell and cell fusion. Our findings show that the substitution of bone marrow in diseased animals by healthy bone marrow, even prior to the onset of neurodegeneration, is not fast enough to stop neuronal loss in time. Conversely, avoiding bone marrow replacement and ensuring a regular supply of healthy cells through continuous, daily transplants, the neurodegenerative milieu of PCD is enough to attract those transplanted elements. Furthermore, in the most affected cerebellar regions, more than a half of surviving neurons undergo a process of cell fusion. Therefore, this method deserves consideration as a means to impede neuronal cell death.

Topic: Neurogenesis and neuroplasticity mechanisms
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Space Station and Space Cabin Testing

For Earth Orbiting Space Stations neither expandable, extensible, nor converted propellant tanks appear as suitable for manned operations as a specially designed cabin regardless of the mission to be performed. While an interesting possibility, use of converted propellant tanks offer little advantage when viewed in the light of the overall space station system problem.\nDuring the past two years studies have been conducted in some depth of the cabins associated with space station systems suitable for launch by Titan III C, Saturn IB, and Saturn 5 boosters. These studies have considered various crew complements, supporting ferries f and the effects of rotation for the generation of artificial "G".\nConsidering the requirements for integrating power supplies, thermal control* life support, attitude control, orbit propulsion, specific mission equipment, rendezvous, docking, communications, navigation, and crew creature comforts, the development of an efficient usable cabin becomes a task of significant proportions. Applying the constraints of removable and storable equipment to the fixed sizes and shapes of booster tankage makes the problem more difficult, the results less than optimum, and the increased cost substantial.

Topic: Spacecraft Design and Technology
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
DIVERSIFICATION OF ECONOMIC SITUATION OF HOUSEHOLDS

In Poland there is still a disparity within the scope of income and expenses of households, which is unfavorable to farm families and leads to a significant range of poverty in the country. Economic situation of households, particularly farmers, is affected by political and economic changes, started in Poland in the last decade of the previous century. The highest real decrease of income among the social and professional groups, took place in farmers' households. There is a significant income disparity between the people living on rural and urban area, which is unfavourable to rural population and between households maintaining agricultural holdings and without agricultural holding, which is unfavourable to the first group. Difficult economic situation in farm families is inter alia due to deterioration of the relation of prices in agriculture, decrease of agricultural production profitability, increase of the prices of means for production. The supply of agricultural raw materials exceeded the demand for them. Farms found it difficult to sell their products. The income structure has changed. The share of income from individual agricultural holdings decreased and income from non-agricultural work and social benefits increased. Poland's integration with EU and having included Polish agriculture in Common Agricultural Policy contributed to the improvement of economic situation of agricultural holdings, mainly as a result of funds inflow within direct payments. The amount of support depended on the size of the holding, therefore the majority of holdings in Poland, that is small holdings, did not benefit much.

Topic: Agricultural economics and policies
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
Identification of air and sea-surface targets with a laser range profiler

Current coastal operations have to deal with threats at short range in complex environments with both neutral and hostile targets. There is a need for fast identification, which is possible with a laser range profiler. A number of field trials have been conducted to validate the concept of identification with a laser range profile. A laser range profiler with a high bandwidth, fast laser receiver was used to perform tests on the capability of a laser range profiler for ship identification. Typical rise and fall times are 2 ns corresponding to a range resolution of 0.6 meter. The experimental profiles of the ships and simulated range profiles based on 3D target models show very good correspondence. It is shown that laser range profiles match closely the geometric structure of the ship. Furthermore, the good match between experimental and simulated laser range profiles means that a database of laser range signatures can be constructed from 3D-models, thus simplifying the database creation. Based on the experiments a system model was made for the range profiling of air targets. The validated system model shows that air targets can be identified at ranges of several tens of kilometers. An identification algorithm was used to distinguish three aircraft from their simulated range profile with good results. Â© 2009 SPIE.

Topic: Advanced Optical Sensing Technologies
Subfield: Instrumentation
Field: Physics and Astronomy
Domain: Physical Sciences
Reaction of FcCCC(O)R (Fc = ferrocenyl) with Ru<sub>3</sub>(CO)<sub>12</sub> leading to unexpected nitro-group reduced ruthenoles and 1,2-CO-inserted triruthenium clusters

Unexpected nitro-group reduced ruthenoles and 1,2-CO-inserted π-coordinated triruthenium clusters were isolated during the reactions of Ru<sub>3</sub>(CO)<sub>12</sub> with ferrocene-containing 1,3-ynones.

Topic: Organometallic Complex Synthesis and Catalysis
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
ETMR-32. SUPRATENTORIAL NEUROEPITHELIAL TUMOR WITH PLAGL1 FUSION: A CASE REPORT

Abstract BACKGROUND Supratentorial neuroepithelial tumor with PLAGL1 fusion has emerged as a novel subgroup within pediatric brain tumors. Despite its recent identification, critical aspects such as optimal clinical characteristics and management strategies remain elusive. This case report aims to contribute essential insights to the growing body of literature surrounding this enigmatic tumor entity, providing a detailed exploration of its clinical presentation and histopathological features. METHODS A retrospective chart review was conducted, and relevant data were analyzed. RESULTS An 11-year-old female presented with a two-week history of headaches, vomiting, lethargy, and decreased oral intake. Neuroimaging revealed a left frontal lesion with conspicuous mass effect and midline shift, prompting urgent craniotomy due to sudden onset altered mental status. Histopathological analysis revealed a hypercellular glial neoplasm characterized by perivascular pseudorosettes, scattered microcalcifications, microcysts, and areas of necrosis. Immunohistochemical staining revealed GFAP positivity in a substantial subset of tumor cells, rare dot-like positivity for EMA, and diffuse membranous and focal dot-like positivity for D240. Olig2 was mostly negative, indicating the absence of Oligodendrocyte lineage differentiation. The tumor exhibited an elevated Ki-67 proliferation index (approximately 20-30%). Fluorescence in situ hybridization (FISH) studies were negative for RELA, YAP1, and C19MC rearrangements. Targeted next-generation sequencing unveiled an EWSR1-PLAG1 fusion and methylation profiling classified the tumor as “Neuroepithelial tumors, PLAG1-fused” with high confidence. Given the morphological resemblance to anaplastic ependymoma, the therapeutic recommendation included focal irradiation (54 Gy) with proton therapy. The patient, now 12 months post-therapy, is showing favorable clinical outcomes. CONCLUSION This case report underscores the clinical and histopathological intricacies of supratentorial neuroepithelial tumors with PLAGL1 fusion. The identification of EWSR1-PLAG1 fusion and associated molecular alterations informs diagnostic considerations and treatment strategies for this novel entity, emphasizing the importance of continued research to enhance our understanding of its clinical behavior and optimal management approaches.

Topic: Hippo pathway signaling and YAP/TAZ
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Study on Personalized Data Broadcasting Service using TV-Anytime Metadata

The number of broadcasting channels and contents are increasing with the arrival of digital broadcast and various broadcasting medium. However, there is a limit on searching of the program by using conventional program guide. Therefore, personalized broadcasting service to provide the environment, that user is able to consume his/her customized broadcasting contents at anytime, is standardized by TV-anytime (TVA) forum. TV-anytime forum (TVAF) is standardizing technology for the search, selection, acquisition and rightful use of contents on local and remote personal storage systems from both broadcast and IP network services. TVA metadata specifications are classified into phase 1 and phase 2. TV-anytime phase 1 (TVA-1) specified the metadata for targeting of AV contents. TV-anytime phase 2 (TVA-2) that extends TVA-1, is defining specifications that are content packaging for various contents and targeting metadata for adaptive consumption on home networking environment. Especially, the structure of data broadcasting contents have different from that of AV contents. Therefore, it is necessary to new structure of the metadata for personalized data broadcasting service and new mechanism for data flow of broadcasting system. In this paper, we introduce a method and system for personalized data broadcasting service using TVA metadata. Appropriate metadata structure for personalized data broadcasting is explained by comparison with package metadata and data broadcasting contents. New scenario and contents structure for personalized data broadcast is described. Therefore the system and data flow mechanism for personalized data broadcasting service is presented

Topic: Technology and Data Analysis
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Protection of the Underwater Part of the Ship’s Hull with Antifouling Coatings

The development of world trade is based on the global transport of goods and people, and the most advantageous and most common form of transport is transport by ships, which, with their service in a demanding medium such as seas and oceans, must withstand numerous challenges such as corrosion and fouling. The hull and the rest of the structure of modern ships are made mainly of carbon steel and aluminum, which are susceptible to corrosion damage in the marine environment and require adequate protection against corrosion. The most commonly used method for corrosion protection on ships is protection with coatings that form an impermeable barrier between steel or aluminum and marine environment. In addition to the corrosive effects of the sea, the outer surface of the ship’s hull is also exposed to fouling of marine organisms such as bacteria, algae and shellfish. By settling on the ship’s hull, they increase the friction between the hull and seawater, increase the weight of the ship and cause damage to the protective coating. The most commonly used method for protection against fouling are anti-fouling coatings that are applied to the outer surface of the underwater part of the ship’s hull. Antifouling coatings have been in use for many years, but with raising awareness of the protection of the sea and marine organisms and the progress of technology, some old types of antifouling coatings based on tributyltin base have been abandoned and banned, and new, more effective and less harmful coatings for the marine world are coming into use. Currently, the most common antifouling coatings in shipbuilding are self-polishing antivegetative coatings based on copper biocides. In this paper, the efficiency and quality of antifouling coatings with an insoluble matrix and self-polishing coatings on steel and aluminum substrates were studied.

Topic: Marine Biology and Environmental Chemistry
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Additional file 1 of The mediating roles of anthropo-metabolic biomarkers on the association between beverage consumption and breast cancer risk

Additional file 1: Table S1. Beverage items used in the analysis. Table S2. Overview of genome-wide association study data. Table S3. Associations between beverage consumption and risk of breast cancer stratified by baseline age in the Guangzhou Biobank Cohort Study. Table S4. Associations between beverage consumption and risk of breast cancer stratified by baseline menopausal status in the Guangzhou Biobank Cohort Study. Table S5. Associations between beverage consumption and risk of breast cancer in 13,534 participants, excluding breast cancer or death events within the first year of follow-up in the Guangzhou Biobank Cohort Study. Table S6. Associations between beverage consumption and risk of breast cancer in the Guangzhou Biobank Cohort Study by proportional subdistribution hazards regression. Table S7. Associations between beverage consumption and risk of breast cancer in the Guangzhou Biobank Cohort Study using four partially adjusted models. Table S8. Associations between beverage consumption and 16 baseline anthropo-metabolic markers in the Guangzhou Biobank Cohort Study. Table S9. Mediation analysis with anthropo-metabolic markers as potential mediators for the association between beverage consumption and risk of breast cancer in the Guangzhou Biobank Cohort Study. Table S10. Summary information of the single nucleotide polymorphisms (SNPs) used as instrumental variables for beverage consumption in univariable Mendelian randomization. Table S11. Mendelian randomization estimates for the causal associations between sugar sweetened beverages consumption and estrogen receptor (ER)-positive/negative breast cancer. Table S12. Mendelian randomization estimates for the causal associations between sugar sweetened beverages consumption and anthropo-metabolic biomarkers. Table S13. Mendelian randomization estimates for the causal associations between anthropo-metabolic biomarkers and overall breast cancer. Figure S1. Flow diagram of participants selection.

Topic: Nutritional Studies and Diet
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Community engagement to co-design and deliver public health interventions in newly arrived migrants

Abstract Alison Crawshaw will talk about her participatory research that uses design thinking to develop community-based strategies to improve health outcomes in migrant populations. She will summarise the benefits of using community-based approaches and co-designing public health initiatives with affected migrant communities, bringing in lessons learned from a recent project with the Congolese community in London.

Topic: Global Public Health Policies and Epidemiology
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Tranexamic acid for the prevention and treatment of tonsillectomy-related haemorrhage in adults

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the effectiveness of tranexamic acid in reducing tonsillectomy‐related haemorrhage in adults. To identify the morbidity associated with the administration of tranexamic acid.

Topic: Obstructive Sleep Apnea Research
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Supplementary Tables 1 - 4 from MicroRNA-200a Promotes Anoikis Resistance and Metastasis by Targeting YAP1 in Human Breast Cancer

&lt;p&gt;PDF file - 78K, Table S1. List of primer and siRNA sequences; Table S2. Intersection between Predict target of miR-200a and genes that regulate the apoptotic processes; Table S3. The number of zebrafish embryos with migrating tumor (Dil) cells transfected with miR-200a, YAP1 siRNA, miR-Ctrl , Scramble RNA, antagomiR-200a and antagomiR-Ctrl respectively; Table S4. The number of migrated cells per tail vein of zebrafish embryos that had migrating tumor (Dil) cells transfected with miR-200a, YAP1 siRNA, miR-Ctrl and Scramble RNA, antagomiR-200a and antagomiR-Ctrl respectively&lt;/p&gt;

Topic: Hippo pathway signaling and YAP/TAZ
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Progressivism In The Elementary School Curriculum: A Systematic Literature Review

Progressivism is one of the schools of modern educational philosophy which is based on changes in the implementation of education for the better. Progressivism requires the basics of education that are meaningful for every student. The of progressivism refers to the implementation of education that is carried out by involving an active and centered role for students. The of progressivism that sided with students became one of the philosophical foundations in the development of the education curriculum in Indonesia, including education at the elementary school level. Curriculum changes took place in 2013 following the direction and policies of the government. This curriculum was introduced with the term "curriculum 2013 or K-13". The 2013 curriculum and progressivism conform to concepts and goals for the progress of education in Indonesia. The 2013 curriculum and the of progressivism serve as guidelines in implementing education that is oriented towards the potential and experience of students, especially students in elementary schools. Elementary school education is the main education in shaping the personality development of students to become quality students and born as a generation who will answer every challenge of the new civilization era to have a prosperous life in realizing the goals of Indonesia's national education

Topic: Education and Critical Thinking Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Abstract B29: Effects of prenatal exposure to cancer treatment: The development of a placental murine xenograft model

Abstract The aim of this study was to develop a suitable murine xenograft model to examine the possible effect of drugs or chemotherapeutic agents on the placental tissue. Methods: The test population consisted of 4 examination groups of six immunodefficient nude mice. After the mice were ovariectomised and hormonal stimulated (17b estradiol and progesterone pellets), placental tissue derived from first and third trimester pregnancies was engrafted subcutaneously bilateral in the interscapular fat pad. hCG (human chorionic gonadotrophin) secretion was measured in serum and urine by an enzyme-linked immunosorbent assay (ELISA). To examine the viability and preservation of the placental tissue, factors for proliferation (hCG, Ki67), apoptosis (cleaved caspase-3) and murine angiogenesis (CD31) were evaluated by immunohistochemistry (IHC). The expression level of genes relevant for the angiogenesis (IGF-1, PGF, IGF-2), inflammation (eNOS) and proliferation (Flk-1, Flt-1) was compared by using reverse transcription- quantitative real-time polymerase chain reaction (RT-qPCR). Results: Comparing the placental tissue before and after engraftment, we found preserved structure and histological features. Also, the PCR analysis showed preserved genetic characteristics of the primary engrafted placental tissue. hCG secretion, evaluated by ELISA in the urine and blood, was present for 3 weeks. Conclusion: We created a murine xenograft model with proven stability and preserved structure of the engrafted placental tissue for 3 weeks. This established murine xenograft model will be useful to examine the effect of cancer treatment; moreover, it could serve as a model for other fetal toxicity studies. Citation Format: Magali Verheecke, Wout Devlies, Els Hermans, Frédéric Amant. Effects of prenatal exposure to cancer treatment: The development of a placental murine xenograft model. [abstract]. In: Proceedings of the AACR Special Conference: Patient-Derived Cancer Models: Present and Future Applications from Basic Science to the Clinic; Feb 11-14, 2016; New Orleans, LA. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(16_Suppl):Abstract nr B29.

Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The Relation of Electrolytes to the Cardiac Rhythm of <i>Palinurus</i> (<i>Jasus</i>) <i>Lalandii</i> and <i>Octopus Horridus</i>

ABSTRACT The heart of Palinurus lalandii and the ventricle of Octopus horridus maintain their normal rhythm for long periods in solutions containing only sodium and calcium chlorides. The removal of calcium from the perfusion fluids causes systolic arrest in both hearts. Both hearts are sensitive to very low concentration of potassium when perfused with potassium-free fluid. Excess of magnesium and strontium produce the same effect as excess of calcium, but magnesium cannot be successfully substituted for calcium in the perfusing fluid. The physiological range of H ion concentration is determined for the two preparations. Both hearts have low temperature optima, and the high limit of their range is in the neighbourhood of 20° C.

Topic: Cephalopods and Marine Biology
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Assessment of Lithogenic Risk in Children Based on a Morning Spot Urine Sample

Bonn Risk Index determined from urine samples collected between 08:00 and 10:00 appears optimal in separating stone formers from healthy subjects, and appears as useful as the value determined from 24-hour urine collection. Investigation of this diurnal sample simplifies diagnosis in pediatric stone disease without loss of clinical information.

Topic: Kidney Stones and Urolithiasis Treatments
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences