jimnoneill/paper-to-field-training huggingface dataset:
On the molecular mechanisms of mitotic kinase activation

During mitosis, human cells exhibit a peak of protein phosphorylation that alters the behaviour of a significant proportion of proteins, driving a dramatic transformation in the cell's shape, intracellular structures and biochemistry. These mitotic phosphorylation events are catalysed by several families of protein kinases, including Auroras, Cdks, Plks, Neks, Bubs, Haspin and Mps1/TTK. The catalytic activities of these kinases are activated by phosphorylation and through protein–protein interactions. In this review, we summarize the current state of knowledge of the structural basis of mitotic kinase activation mechanisms. This review aims to provide a clear and comprehensive primer on these mechanisms to a broad community of researchers, bringing together the common themes, and highlighting specific differences. Along the way, we have uncovered some features of these proteins that have previously gone unreported, and identified unexplored questions for future work. The dysregulation of mitotic kinases is associated with proliferative disorders such as cancer, and structural biology will continue to play a critical role in the development of chemical probes used to interrogate disease biology and applied to the treatment of patients.

Topic: Microtubule and mitosis dynamics
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Vision, Kinesthesis, and Control of Hand Movement by Young and Old Adults

This study examined the accuracy with which 20 young (18 to 24 yr.) and 32 old (55 to 85 yr.) adults were able to move their hands when not allowed to guide them visually. They tried to touch a target spot given either visually or kinesthetically, under conditions in which the target either remained present during the response or was discontinued prior to the response. They also tried to touch points on the face with eyes closed and wrote their names and common words with and without visual input. While there was slight evidence of age-related decline in accuracy of moving the hand to a target location in some conditions, older adults appear to use kinesthetic cues to the target location as effectively as visual cues. The absence of age effects on touching the face or writing with the eyes closed suggests that the kinesthetic and motor control systems are relatively well preserved in healthy older adults.

Topic: Tactile and Sensory Interactions
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Combined humerus capitulum and olecranon fractures: Surgical intervention in a saber-related injury

This report outlines the successful surgical management of a 30-year-old taxi driver with concurrent humerus capitulum and olecranon fractures due to a saber assault. The intervention involved decontamination, ulnar nerve exploration, and osteosynthesis, leading to a favorable outcome with restored joint function. This case underscores the significance of timely and comprehensive surgical approaches in complex fractures.

Topic: Elbow and Forearm Trauma Treatment
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Peranan Motivasi Kerja dalam Kinerja Pegawai pada Kantor Kecamatan Tanjungbalai Utara Kota Tanjung Balai

Aim of scope this research is analysis the role of work motivation in employee performance in Tanjung Balai North Tanjungbalai District office Research method is a method used by researchers in collecting research data. In this study the method used is a qualitative research method which is a research method whose case study leads to a detailed and in-depth description of the portrait of what actually happens according to what is in the field of study. The results showed that the role of work motivation in employee performance in Tanjung Balai North Tanjungbalai District office that motivation is very influential is the work itself which it has if appropriate, but in reality there are still employees who find it difficult to carry out motivation due to the employee wanting to retire, this ditujukkan of employees in completing the work given is always not maximally done well, and the work given to employees in accordance with the expertise and ability of employees so that in the completion of the work will cause a feeling of dislike of the work with results that are not good too. So that it can be said that the work of the employee itself motivates them to work.

Topic: Employee Performance and Management
Subfield: Human Factors and Ergonomics
Field: Social Sciences
Domain: Social Sciences
FER1L6 ameliorates insulin resistance by regulating GLUT4 expression

Insulin resistance, a prominent characteristic of type 2 diabetes, has been extensively studied. In our investigation, we examined the effect of Eudesmin on insulin resistance in 3T3-L1 adipocytes and HepG2 cells. Additionally, we analyzed the alterations in mRNA expression in insulin-resistant HepG2 cells through transcriptomic techniques. Subsequently, we assessed the changes in mRNA expression in insulin-resistant HepG2 cells following Eudesmin treatment. Our analysis revealed 13 differentially expressed genes that were commonly observed. Notably, FER1L6 exhibited the most significant changes, with a marked upregulation in mRNA expression in insulin-resistant HepG2 cells. Consequently, we conducted functional experiments to validate the role of fer-1 like family member 6 (FER1L6). Specifically, through gene knockdown experiments, we observed a significant enhancement in glucose transporter type 4 (GLUT4) expression and an improvement in insulin resistance status in cell models. Therefore, FER1L6 emerges as a promising therapeutic target for insulin resistance.

Topic: Metabolism, Diabetes, and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Flurandrenolide-Impregnated Tape for Granuloma Gluteale Infantum

<h3>To the Editor.—</h3> Two cases of granuloma gluteale infantum (GGI) were treated with a flurandrenolide-impregnated tape. The cutaneous lesions flattened rapidly, but the erythema was more persistent. The lack of response to a noncorticosteroid-containing tape in the second case suggests that the response was attributable to the antiinflammatory effect of the medication. The prolonged use of the tape that contained flurandrenolide produced atrophy at the site of application. <h3>Report of Cases.—Case 1.—</h3> A baby girl was treated with 0.025% fluocinolone acetonide ointment for diaper dermatitis at the age of 3 months. Initially responding to therapy, the dermatitis exacerbated after treatment was discontinued. In January 1974, a red tumor appeared within the diaper contact area, and orally given antibiotics were without effect for a presumed secondary pyodermia. The tumors increased in size the number during an episode of diarrhea that lasted for ten days. The patient was referred to us

Topic: Neonatal skin health care
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
Decomposition of Differences in Income Distributions Using Quantile Regression

Abstract The paper deals with microeconometric techniques useful for the study of differences between groups of objects, methods that go beyond simple comparison of average values. Techniques for the decomposition of differences in distributions by constructing counterfactual distributions were considered. Using the Machado-Mata quantile regression approach the empirical decomposition of the inequalities in income distributions of one-person households in urban and rural areas was performed. We employed data from the Household Budget Survey for Poland in 2012. It was found that the tendency towards increased income inequalities between urban and rural residents when moving to the right of the income distribution can be observed. The rural residents are at a disadvantage. The decomposition of the inequalities revealed a growing share of the part explained by different characteristics of people and a declining share of the unexplained part, associated with the evaluation of those characteristics.

Topic: Agricultural economics and policies
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
Request for Information regarding Pharmacy Operation of a Medical Staff Library

Journal Article Request for Information regarding Pharmacy Operation of a Medical Staff Library Get access Robert E. Northern Robert E. Northern Director Pharmacy Services Oxford-Lafayette County Hospital Box 946 Oxford, MS 38655 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 37, Issue 9, 1 September 1980, Page 1183, https://doi.org/10.1093/ajhp/37.9.1183a Published: 01 September 1980

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
The Effect of Financial Literacy, E-Money Use and Self-Control on the Consumptive Behavior of Accounting Students in Batam City

Consumptive behavior is the act of consuming an item or service excessively with high intensity that tends toprioritize wants over needs. The study aims to determine the effect of financial literacy, e-money usage, and selfcontrol on the consumptive behavior of accounting students in Batam city. The total population was 1,354accounting students with a sample of 93 accounting students. This study uses a quantitative approach with simplerandom sampling technique using primary data obtained from distributing questionnaires online using googleform. The data in this study were processed using SPSS (Statistical Package for Social Science) software version26. The data analysis technique in this study used validity test, reliability test, classical assumption test andhypothesis testing. The results of the t test research explain that financial literacy and the use of e-money partiallyhave no effect on the consumptive behavior of accounting students. Self-control partially affects the consumptivebehavior of accounting students. The results of the F test research explain that financial literacy, e-money usage,self-control simultaneously have a significant effect on the consumptive behavior of accounting students with apercentage of 17.9% and the remaining 82.1% is influenced by other variables.

Topic: Financial Literacy and Behavior
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Male infertility due to large-headed multiflagellar polyploid spermatozoa

Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie w on Qe ios Male infertility due to large-headed multiflagellar polyploid spermatozoa

Topic: Sperm and Testicular Function
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Predicting Query Performance for User-based Search Tasks

Abstract Query performance prediction aims to determine in advance whether a user’s search request will return a useful answer set. The success of such prediction attempts are currently evaluated by calculating the correlation between the predicted performance and standard information retrieval metrics of system performance such as average precision. However, recent work suggests that there is little relationship between average precision and the performance of users when carrying out search tasks. Direct measures of user performance offer another way of evaluating the effectiveness of search systems; this is of particular importance in the framework of query prediction, since one of the goals of prediction is to warn users when search results are likely to be poor. We therefore investigate the relationship between current prediction techniques and user-based performance measures. Our preliminary results show that the performance of the predictors differs strongly when using system-based compared to user-based performance measures: predictors that are significantly correlated with one measurement are often not correlated with the other. In general, the predictors are more correlated with average precision rather than with user performance.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Diverse application of Phoenix sylvestris: A potential herb

Phoenix sylvestris is commonly known as Indian date and is native to India and southern portions of Pakistan. It is traditionally important and known for its nutritional values throughout the world. It is a rich source of carbohydrate, phenols, amino acids, flavonoids, tannins, alkaloids, terpenoids, dietary fibers, essential vitamins and minerals. Different parts of the plant exhibit diverse medicinal properties such as being antipyretic, cardiotonic, laxative, diuretic and antioxidant. In the present review, an attempt has been made to compile most of the information available regarding the distribution, cultivation, phytochemical characteristics, Ayurvedic properties, ethno-pharmacological, medicinal and non-medicinal uses of P. sylvestris in the last four decades.

Topic: Date Palm Research Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Identification of the Hypoglycemic Active Components of Lonicera japonica Thunb. and Lonicera hypoglauca Miq. by UPLC-Q-TOF-MS

Lonicera japonica Thunb. and Lonicera hypoglauca are famous Chinese medicines used for hyperglycemia; however, the specific compounds that contributed to the hypoglycemic activity and mechanism are still unknown. In this study, the antidiabetic activity of L. japonica buds and L. hypoglauca buds, roots, stems, and leaves extracts was primarily evaluated, and the L. japonica buds and L. hypoglauca buds, roots, and stems extracts displayed significant hypoglycemic activity, especially for the buds of L. hypoglauca. A total of 72 high-level compounds, including 9 iridoid glycosides, 12 flavonoids, 34 organic acids, and 17 saponins, were identified by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) combined with the fragmentation pathways of standards from different parts of L. japonica and L. hypoglauca extracts. Among them, 19 metabolites, including 13 saponins, were reported for the first time from both medicines. Seven high-content compounds identified from L. hypoglauca buds extract were further evaluated for hypoglycemic activity. The result indicated that neochlorogenic acid, chlorogenic acid, isochlorogenic acid A, isochlorogenic acid B, and isochlorogenic acid C displayed significant antidiabetic activity, especially for isochlorogenic acid A and isochlorogenic acid C, which demonstrated that the five chlorogenic-acid-type compounds were the active ingredients of hypoglycemic activity for L. japonica and L. hypoglauca. The potential mechanism of hypoglycemic activity for isochlorogenic acid A and isochlorogenic acid C was inhibiting the intestinal α-glucosidase activity to block the supply of glucose. This study was the first to clarify the hypoglycemic active ingredients and potential mechanism of L. japonica and L. hypoglauca, providing new insights for the comprehensive utilization of both resources and the development of hypoglycemic drugs.

Topic: Food Quality and Safety Studies
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Cyanidin and cyanidin-3-glucoside derived from <i>Vigna unguiculata</i> act as noncompetitive inhibitors of pancreatic lipase

The consumption of legumes positively correlated with the reduction of body weight. In the present study, we identified and evaluated pancreatic lipase inhibitors from Vigna unguiculata and unraveled their mode of inhibition. The highly sensitive fluorometric method was adopted to access the pancreatic lipase activity and the ethanolic extract of Vigna unguiculata showed the maximum inhibition (IC<sub>50</sub> of 15.2 µg/ml). Cyanidin and cyanidin-3-glucoside are the major anthocyanins observed in Vigna unguiculata. The IC<sub>50</sub> value of cyanidin was 28.29 µM which was 6.5-fold higher than the cyanidin-3-glucoside (188.28 µM). We determined an apparent K<sub>i</sub> of 27.28 µM for cyanidin and cyanidin-3-glucoside (88.97 µM) with noncompetitive inhibition. Collectively, these results suggest that the glycosylation of the anthocyanidins significantly reduces lipase inhibition. The noncompetitive inhibition of pancreatic lipase by Vigna unguiculata anthocyanins may exert significant pharmacological activities toward obesity complications by calorie restriction. PRACTICAL APPLICATIONS: The results of this study emphasize the importance of legumes in our diet to combat obesity-related complications. Consumption of legumes minimizes fat absorption by inhibiting the action of the fat-digesting enzyme.

Topic: Natural Antidiabetic Agents Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Hastigerinella Cushman, 1927 And Clavigerinella Bolli, Loeblich & Tappan, 1957 (Rhizopoda, Foraminiferida): Proposed Conservation Of The Usage By Designation Of Hastigerina Digitata Rhumbler, 1911 As The Type Species Of Hastigerinella

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.

Topic: Marine Biology and Ecology Research
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Determinants of farmers’ decision to choice market outlets: Evidence from milk producer farmers in Ada’a Berga District Ethiopia

In Ethiopia, many initiatives have been implemented to empower smallholder dairy farmers to develop viable livelihoods from the sector. The problem with these policies is the inability to reach farmers at large, and dairy farmers in rural areas are always challenged to deliver milk and milk products faster to the final market. The study was aimed at investigating factors that influence market channel choices among dairy producers in Ada’a Berga district Ethiopia. This paper uses data from a survey of 123 dairy producer households in four rural kebeles to analyse the factors that influence the choice of a milk marketing channel. Multivariate probit econometric model results show that income from dairy source, market information and educational level of household affected wholesaler outlet. The choice of consumer outlet is influenced by family size, membership in a dairy cooperative, market information, non-dairy income and income from dairy source. Number of milking cows, membership in a dairy cooperative and non-dairy income determined the choice of dairy cooperative outlet. The choice of district retailer’s market outlet was affected by sex of households, membership in a dairy cooperative and income from dairy sources. Choice of rural collector outlet is negatively influenced by non-dairy income and access to an extension contact. Therefore, policies should be designed that encourage farmers’ cooperatives, contract farming and collective action in order to lower transaction costs, expand market information for dairy producers, expand extension services and expand infrastructures such as road and transportation facilities, which are needed to promote the effective marketing of milk through all outlets.

Topic: Agricultural Innovations and Practices
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Advancing IUWM through an understanding of the urban water balance

Integrated urban water management (IUWM) requires the management of the urban water cycle in sympathy with the hydrological water cycle. Urban systems significantly alter the hydrological water cycle. Under natural conditions the water inputs at any point in the landscape are precipitation and overland flows; while the outputs are via surface flows, evapo-transpiration and groundwater recharge. The large volumes of piped water introduced with the change to an urban setting and the introduction of vast impervious areas strongly impact on the water balance, increasing in-flows and dramatically altering the out- flow components. IUWM seeks to change the impact of urban development on the natural water cycle. One approach is to establish an inner, urban, water cycle loop through the implementation of reuse strategies. Developing this urban water cycle loop requires an understanding both of the natural, pre-development, water balance and the post-development water balance. Accounting for flows in the pre- and post-development systems is an important step toward limiting urban impacts on the natural water cycle. This paper investigates urban water balancing and preliminary identification of reuse strategies for the case study of the proposed Tamala Park development in Perth, as the first steps toward an integrated water reuse strategy. The hydrology and hydrogeology of the site are examined. Overland flows are not a feature of the site with rainfall leaving the site as either evapotranspiration or recharge to groundwater. The unconfined Superficial aquifer is identified as suited to aquifer storage and recovery. Changes to the site water balance due to urbanisation include the significant inflow and outflow of piped water. It is projected that the small allotment sizes proposed would have a beneficial impact on garden water use and hence piped inflow. Water accounting for the developed case showed a decrease in evaporation and an increase in recharge. Reuse strategies should therefore aim to exploit the excess recharge - through groundwater abstraction and roof runoff capture - as a component of an inner urban water cycle loop. Volumetrically, this excess could supply projected in-house uses. Further, if wastewater was reused for irrigation demands the need for mains supply could be eliminated and wastewater discharges halved.

Topic: Water resources management and optimization
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Teacher Training in Educational Technology in Rumania

Abstract This paper deals with four aspects of teacher training in educational technology: general information on the education system in Rumania teacher training in the utilization of educational media teacher training with a view to the improvement of teaching‐learning systems teacher training in the new information and communication technologies In each of these areas of teacher training, the problems and perspectives related to developments of educational technology are considered.

Topic: Global Education Systems and Policies
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
A Conceptual History of Civil Society: From Greek Beginnings to the End of Marx

The idea of civil society has undergone a renaissance in recent years, but missing from this literature is an explanation for its historical transformation in meaning. Originally civil society was synonymous with political society, but the common modem meaning emphasizes autonomy from the state. This paper traces this historical transformation within the context of the history of ideas, and suggests that the critical event was an eighteenth-century reaction against the rationalistic universalism associated with the French Enlightenment. The continued significance of the question of universalism is suggested by the fact that universalistic Marxist Leninist theories provided the ideological underpinnings for the destruction of civil society in Eastern European nations. The paper concludes that three elements are essential to the modern understanding of civil society: its autonomy from the state, its interdependence with the state, and the pluralism of values, ideals and ways of life embodied in its institutions.

Topic: Political Economy and Marxism
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Paradox of Plenty: A Social History of Eating in Modern America.

A sweeping social history of food and eating in America, exploring the economic, political, and cultural factors that have shaped the American diet from 1930 to the present. This book is intended for those interested in US food habits and diets during the 20th century, American history, American social life and customs.

Topic: Culinary Culture and Tourism
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences