jimnoneill/paper-to-field-training huggingface dataset:
RNA Splicing—Cutting and Pasting Genes

Science in general, and specifically the science of life, offers an intriguing path to walk along. As you deepen your understanding of a particular topic, you become aware of things you did not see at all when you started. Sometimes, this new seeing even drives you to reconsider and redefine very basic concepts that you learned along the way. This is exactly what happened after we discovered a process called RNA splicing. In RNA splicing, pieces of genetic instructions are cut and pasted together to form the final instructions for producing proteins. The discovery of RNA splicing has driven us to rethink what we previously believed about genes, which are the most fundamental units of information in biology. In this article, I will tell you what we discovered about RNA splicing, how it influenced our ideas about genes, and how we now use this knowledge to significantly improve people’s lives.

Topic: Axon Guidance and Neuronal Signaling
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Research and modeling of laser ablation by ultra-short laser pulses for metal targets

Abstract In this article a new mathematical model for a laser metal ablation by ultra-short duration laser pulses is proposed. The computational process is based on a two-temperature hydrodynamic model for electrons and ions. Some improvements are made and wide-range equation of state for metals is included in model. The results of the computer simulation of ablation depth for aluminum and copper are compared with experimental data at a different laser fluency values. We obtained a good agreement between the experimental and calculated data on the ablation depth.

Topic: Laser-induced spectroscopy and plasma
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Time-Dependent Demineralization of Tilapia (Oreochromis niloticus) Bones Using Hydrochloric Acid for Extracellular Matrix Extraction

Tilapia (Oreochromis niloticus) is a widely cultivated fish in tropical and subtropical regions such as the Philippines, generating substantial waste during processing, including bones that are a valuable source of extracellular matrix (ECM). However, the extraction of ECM from fish bones requires an essential step of demineralization. This study aimed to assess the efficiency of tilapia bone demineralization using 0.5 N HCl at different time durations. By evaluating the residual calcium concentration, reaction kinetics, protein content, and extracellular matrix (ECM) integrity through histological analysis, composition assessment, and thermal analysis, the effectiveness of the process was determined. Results revealed that after 1 h of demineralization, the calcium and protein contents were 1.10 ± 0.12% and 88.7 ± 0.58 μg/mL, respectively. The study found that after 6 h, the calcium content was almost completely removed, but the protein content was only 51.7 ± 1.52 μg/mL compared to 109.0 ± 1.0 μg/mL in native bone tissue. Additionally, the demineralization reaction followed second-order kinetics with an R2 value of 0.9964. Histological analysis using H&amp;E staining revealed a gradual disappearance of the basophilic components and the emergence of lacunae, which can be attributed to decellularization and mineral content removal, respectively. As a result, organic components such as collagen remained in the bone samples. ATR-FTIR analysis showed that all demineralized bone samples retained collagen type I markers, including amide I, II, and III, amides A and B, and symmetric and antisymmetric CH2 bands. These findings provide a route for developing an effective demineralization protocol to extract high-quality ECM from fish bones, which could have important nutraceutical and biomedical applications.

Topic: Meat and Animal Product Quality
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The Art of Investing: The Secrets of Gold and Bitcoin Prices

&lt;p&gt;Market traders frequently buy and sell volatile assets with the goal of maximizing total returns. In the complex market, how to predict the general trend of the market more accurately, how to determine the buying point or selling point, to maximize the target income, is the primary consideration of investors more scientifically and reasonably. In this paper, based on the closing price data of bitcoin and gold on Nasdaq from September 11, 2016 to September 10, 2021,&lt;sup&gt;[1]&lt;/sup&gt; we first build a LSTM neural network prediction model for sliding sequence prediction, on this basis, we build a trading strategy selection model based on nonlinear programming, and introduce Monte Carlo algorithm to optimize the solution.&lt;/p&gt;

Topic: Stock Market Forecasting Methods
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
REDES SOCIAIS NO DESENVOLVIMENTO DE INTELIGÊNCIA COMPETITIVA

A teoria sobre inteligência competitiva (IC) encontra-se em estado muito incipiente e pouco se \nsabe sobre como IC, na prática, é gerada nas organizações. A pesquisa exploratória aqui \nreportada detalha como são estruturadas e como funcionam as redes sociais de informação para \ndesenvolvimento da inteligência competitiva em organização com sistema de IC implantado. \nUtilizou-se uma metodologia mista (quantitativa e qualitativa) para coleta e análise dos dados. \nFoi evidenciada a possível importância do aspecto temporal no estudo de redes sociais, a fim de \nse identificar o papel do estágio de consolidação na atuação da rede, o grau de formalidade que \nexiste, a confiança gerada na IC, a reciprocidade entre os membros, entre outros aspectos. \nConcluiu-se que o processo de IC na organização ainda não se consolidou, o que pode se \nrelacionar com vários dos fatos observados na pesquisa. Observou-se, também, que a rede \nestudada possui conectividade, mas não coerência, o que pode se relacionar com a maneira \nvertical e hierárquica em que se estrutura a rede. Apontam-se alguns caminhos para futuros \nestudos visando desenvolver a teoria que trata de redes sociais na geração de IC. \nPalavras-chave: Inteligência competitiva, redes sociais, redes humanas, redes formais e \ninformais.

Topic: Competitive and Knowledge Intelligence
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Illicit Use of LSD or Psilocybin, but not MDMA or Nonpsychedelic Drugs, is Associated with Mystical Experiences in a Dose-Dependent Manner

Psychedelic drugs have long been known to be capable of inducing mystical or transcendental experiences. However, given the common "recreational" nature of much present-day psychedelic use, with typical doses tending to be lower than those commonly taken in the 1960s, the extent to which illicit use of psychedelics today is associated with mystical experiences is not known. Furthermore the mild psychedelic MDMA ("Ecstasy") is more popular today than "full" psychedelics such as LSD or psilocybin, and the contribution of illicit MDMA use to mystical experiences is not known. The present study recruited 337 adults from the website and newsletter of the Multidisciplinary Association for Psychedelic Studies (MAPS), most of whom reported use of a variety of drugs both licit and illicit including psychedelics. Although only a quarter of the sample reported "spiritual" motives for using psychedelics, use of LSD and psilocybin was significantly positively related to scores on two well-known indices of mystical experiences in a dose-related manner, whereas use of MDMA, cannabis, cocaine, opiates and alcohol was not. Results suggest that even in today's context of "recreational" drug use, psychedelics such as LSD and psilocybin, when taken at higher doses, continue to induce mystical experiences in many users.

Topic: Psychedelics and Drug Studies
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
LHD nb3pwr_PortThrough #185304.1 (analyzed)

Neutral beam injector (NBI) power-PortThrough of beam line 3 (BL3). The effective power that actually reaches the plasma after the negative ion-based neutral particle beam emitted from the NBI system passes through BL3.

Topic: Balance, Gait, and Falls Prevention
Subfield: Physical Therapy, Sports Therapy and Rehabilitation
Field: Health Professions
Domain: Health Sciences
Governance of Online Communities

‘온라인 커뮤니티’는 구성원들 간의 상호작용을 통해 실현&#65381;촉진될 수 있는 공동의 목적을 추구하기 위해 자발적으로 회원으로 가입한 다수인의 네트워크 내지 집단으로서, 동 상호작용이 주로 특정 온라인 인터페이스를 통해 이루어지며 회원들의 자기표상과 활동이 상호 인간관계나 애착을 형성할 만큼의 지속성을 갖는 것을 두루 일컫는다. 현실적으로 그 중 대다수가 소위 ‘운영자’에게 거버넌스에 대한 권한이 집중되어 있는 모습을 보이고 있는데, 거기에는 여러 기술적, 정치역학적, 현실적 이유들과 함께 주로 약관의 성격을 갖는 ‘규약’을 토대로 한 계약법적 기초도 존재한다. 이러한 권한집중과 그 자의적 행사는 종종 운영자와 회원들 사이에 갈등과 분쟁을 촉발하곤 한다. 본고에서는 온라인 커뮤니티가 사단의 성격을 강하게 띨 수 있다는 점, 일응의 외견과는 달리 회원들은 운영자가 제공하는 인프라와 서비스의 일방적 수혜자가 아니라 경제적으로 가치있는 자산들의 기여자이자 등가적 계약의 당사자라는 점, 온라인 커뮤니티는 인격권이라는 헌법적 가치가 구현&#65381;보호되어야 할 중요한 생활공간이라는 점에 주목하여, ‘규약’의 형식적 구속력을 극복하여 전제적&#65381;자의적 거버넌스와 그 폐해를 규범적으로 통제할 필요성을 주장하고, 진정한 사적자치, 공평과 신의칙, 인격적 존엄의 구현을 지향하는 우리의 법질서가 과연 그러한 개입을 요구 및 지지하고 있는지, 그렇다면 그 통제의 방향과 한계는 무엇일지 문제를 민법(民法)의 측면에서 논의해 보았다.‘Online community’ usually refers to a group or network of people in continuous interactions and communications (for a period of time prolonged enough to form personal ties or emotional attachment) who have voluntarily joined the group by way of a specific online site or interface in order to pursue certain defined and shared objectives that can be facilitated through such group interactions. As a matter of fact, many online communities witness its governance-related power and authority being highly concentrated unto the ‘operator’ and, obviously, there are many technical and practical reasons for the phenomenon as well as ostensible legal grounds which revolve around the ‘End User License Agreement (or EULA)’ or equivalents thereto. It is no surprise that the god-like power vested exclusively in the operator is often abused and that conflicts or even legal disputes break out as a result. This article attempts to highlight (i) that online communities share many characteristics with an unincorporated association, (ii) that the members are not merely beneficiaries of the ex gratia services from the operator but rather contributors of resources of economic value and (iii) that constitutional protection of individuals’ dignity, reputation, privacy, etc. should extend to the online spaces. Based thereon, the author argues that the unfettered power of operators must be put under legal scrutiny despite the fine print of the EULA. To back the argument, this article focuses on certain specific institutions and rules of our Civil Law that not only calls for but also lend support to the idea in favor of normative intervention by law to the governance of the ‘Magic Circles.’

Topic: Diverse Topics in Contemporary Research
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Vestibular Function in Vestibular Schwannoma

Abstract\nIntroduction: Traditionally vestibular function has been assessed using caloric irrigations; new methods have failed to reach the same level of accuracy. Vestibular nerve dysfunction occurs with ‘acoustic neuroma’ or ‘vestibular schwannoma. Quantitative testing of hearing by audiometry is much more widely available than quantitative vestibular testing, although consideration of vestibular dysfunction is part of clinical management. Validation of a new method of quantitative vestibular function testing could lead to more widespread integration into clinical practice and affect decision making (i.e. timing of surgery)\nMethods: A non-blind observational cohort study was undertaken in 31 participants. Study endpoints were either one or two separate participant measures in March/April 2013 the September/October 13. All participants underwent caloric and head impulse testing with video-oculography, while 10 underwent audiometric assessment. Repeat testing was performed for 10 subjects, including additional cognitive. The primary outcome was vestibular function test measures.\nResults: Video head impulse was strongly correlated with calorics (p=0.01) and showed good sensitivity (80%) and specificity (70%). Dizziness Handicap Inventory showed no correlation with other vestibular function measures. Participants showed reduced cognitive function tested using the CANTAB battery (p=0.01)\nConclusion: Video head impulse testing is comparable to caloric testing to assess vestibular function. Vestibular lesions may lead to cognitive deficits. Further research is needed to better understand the role of video head impulse testing in vestibular schwannoma.

Topic: Vestibular and auditory disorders
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Proteomic Analysis Identifies Potential Markers for Chicken Primary Follicle Development

Follicles’ development in chicken imparts a major impact on egg production. To enhance the egg-laying efficiency, comprehensive knowledge of different phases of follicular development is a prerequisite. Therefore, we used the tandem mass tag (TMT) based proteomic approach to find the genes involved in the primary follicular development of chicken. The primary follicles were divided into two groups—small primary follicles (81–150 μm) and developed primary follicles (300–500 μm). Differential expression analysis (fold change &gt; 1.2, p-value &lt; 0.05) revealed a total of 70 differentially expressed proteins (DEPs), of which 38 were upregulated and 32 were downregulated. Gene ontology (GO) enrichment analysis disclosed that DEPs were intricate with cellular protein localization, the establishment of protein localization, and nucleoside phosphate-binding activities. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway indicated the involvement of DEPs in different metabolic pathways such as glycolysis, pyruvate metabolism, galactose metabolism, and fructose and mannose metabolism. The current proteomic analysis suggested suitable markers such as Anxa2, Pdia3, and Capzb, which may serve as a potential role for primary follicle development. The present study provides the first insight into the proteome dynamics of primary follicle development and would play a potential role for further studies in chicken to improve egg productivity.

Topic: Animal Genetics and Reproduction
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Evaluation of quality-of-life side effects and duration of therapy in a phase III study of intermittent monotherapy versus continuous combined androgen deprivation

5064 Background: We propose this phase III study comparing the intermittent monotherapy with continuous combined androgen deprivation using an LHRH analogue and ciproterone acetate and associated components of quality of life. Methods: 1045 men with a median PSA of 15.9ng/ml were registered between October 1999 and September 2007. 24% of registered patients have a PSA less than 10ng/ml; 39.3% of registered patients have a PSA greater than 20ng/ml. 90.1% have a T3 tumour and only 13.5% have metastatic prostate cancer. 914 patients (mean age 72) have been randomized 460 to Intermittent therapy and 454 to Continuous. Results: The maximum follow up is 7 years with a median of 2 years. The incidence of side effects is not too high in the Intermittent arm, with 7% of patients reporting Hot Flushes, 10% Gynocomastia, 5% Headaches. There are significantly higher rate of side effects in the Continuous arm (p<0.0001). 30% of patients reported that they were sexually active in the month before registration.There was no significant difference in sexual activity at randomsiation (p=0.67). After randomisation, sexual activity increases in the intermittent group to 33% (6 months), 29% (12 months), 28% (24 months) while in the Continuous arm the corresponding percentages are 20% (p=0.002), 19% (p=0.06), 8% (p=0.0001), respectively. Among the Intermittent patients only 20% (95% CI 15%, 23%) returned to therapy within one year of randomisation because of symptoms or an increase in PSA and 40% (95% CI 30%, 48%) have yet to return to therapy within 3.5 years of randomisation. Patients whose PSA reduces to less than 1 ng/ml at randomisation are off therapy longer than those whose PSA is between 1 and 4 ng/ml ( p<0.05). The median times off therapy are 174 and 100 weeks, respectively.The time on therapy did not depend upon PSA at randomisation, p=0.17. Conclusions: Side effects are less in the Intermittent arm than in the Continuous. Quality of Life is better in the Intermittent arm and namely sexual activity. Among the Intermittent patients only 20% returned to therapy within one year and 40% have yet to return to therapy within 3.5 years. No significant financial relationships to disclose.

Topic: Prostate Cancer Treatment and Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Fascial pulley: Cross‐commissure lip reanimation for inferior division facial nerve paralysis

The risks of causing further harm to the facial nerve are greater in surgery for partial facial paralysis. We present a new active and passive reconstruction technique for paralysis of the buccal-mandibular divisions of the facial nerve. Our fascial pulley technique of reanimation and suspension of the oral commissure produces no further injury to the facial nerve and the eyelids. In addition, it adds a better technique to the armamentarium of the reconstructive surgeon dealing with partial lower facial nerve paralyses.

Topic: Facial Nerve Paralysis Treatment and Research
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
(WA) 0822-4602-4567 Karangan Bunga HUT Polres Tni Korem Tapanuli Tengah Sumut

0822-4602-4567 (KIRIM), Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Tapanuli Tengah Sumatera Utara\n\nLangsung Kirim Bunga Ucapan Hut Polres Tni Korem Kodim PT Tbk Bhayangkara Bhayangkari Tapanuli Tengah Sumatera Utara, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Datarnangka, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Gunung Bentang, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Puncakmanggis, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Sinar Bentang, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Sangrawayang, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Karawang, Kirim Bunga Ucapan Hut Polres Tni Korem Kodim Parungseah\n\nToko Karangan Bunga Papan 24 Jam 0822-4602-4567\n\n\n#KirimBungaUcapanHutTapanuliTengahSumateraUtara, #KirimBungaUcapanHutDatarnangka, #KirimBungaUcapanHutGunungBentang, #KirimBungaUcapanHutPuncakmanggis, #KirimBungaUcapanHutSinarBentang, #KirimBungaUcapanHutSangrawayang, #KirimBungaUcapanHutKarawang, #KirimBungaUcapanHutParungseah\n\n

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Sequential non-cross-resistant chemotherapy regimens (MOPP and CAVmP) in Hodgkin's disease stage IIIB and IV

Fifty consecutive patients with advanced Hodgkin's disease were treated in a multicentre study with 6 cycles of an alternating scheme of MOPP and CAVmP followed by irradiation to a dose of 20 Gy. The objective was to increase complete remission (CR) and cure rates by alternating two effective noncross-resistant regimens with subsequent consolidation of the remission by irradiating bulky nodes. A total of 47 patients completed the treatment and are evaluable. In the first 13 patients the irradiation fields amounted to a total or subtotal nodal irradiation with inclusion of the spleen. In case of organ involvement the affected organ was also included in the irradiation field. The irradiation protocol was later changed to an irradiation of the initially involved sites because of severe leucopenia and thrombopenia. After completion of the chemotherapy 32 (68%) patients (for Stage IIIB and IV patients: 63% and 71%, respectively) achieved a CR, after ending the radiotherapy the percentage of CR increased to 87% (for stage IIIB and IV patients: 90% and 86%, respectively). Five of the patients relapsed in an irradiated and nonirradiated area, three patients in a nonirradiated field. The actuarial 3-year survival rate for the entire group was 86% and for patients in CR 94%. The relapse-free survival was 73%. It is concluded that this alternating chemotherapy scheme followed by irradiation is at least equally effective as MOPP treatment in achieving a CR, and is probably superior in terms of survival.

Topic: Lymphoma Diagnosis and Treatment
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
School responses to the COVID-19 pandemic: An analysis of the state education system of Minas Gerais, Brazil

In addition to the health and economic effects, the COVID- 19 pandemic shocked educational systems with school closures. The Brazilian state of Minas Gerais adopted the Regime Especial de Atividades Não Presenciais (Reanp), followed by heterogeneous strategies and results in each school. This article seeks to understand and analyze how public schools in Minas Gerais responded to the pandemic in 2020 and 2021 regarding the main strategies imposed for the continuity of activities and their possible effects. This descriptive research with a qualitative nature is based on documentary research and semistructured interviews. The results demonstrate the validity of the official strategies but also highlight their limitations and criticisms regarding their content and applicability. Learning losses and impacts related to health, socialization, and engagement in studies were observed, influenced by the socioeconomic contexts of school communities.

Topic: Education during COVID-19 pandemic
Subfield: Education
Field: Social Sciences
Domain: Social Sciences