jimnoneill/paper-to-field-training huggingface dataset:
Investigation of the Neural Target Level of Hyperthyroidism in Premature Ejaculation in a Rat Model of Pharmacologically Induced Ejaculation

ABSTRACT Introduction Association between hyperthyroidism and premature ejaculation was demonstrated in clinical studies. Aim The aim of this study is to determine the target level of changes on ejaculatory physiology under hyperthyroid states. Methods p-Chloroamphetamine (PCA)-induced pharmacologic ejaculation model with 24 male Wistar rats was used in the study. Subcutaneous injection of L-thyroxine for 14 days was performed to induce hyperthyroidism. At the end of the injection period, thyroid hormone status was evaluated by serum thyroid-stimulating hormone measurements in all rats. At the beginning of the operations, complete spinal transections (tx) at the T8-T9 level were performed to half of the L-thyroxine-injected and control group rats. Thus, experimental groups were constructed as follows: Group 1—control-spinal intact (n = 6), group 2—control-spinal tx (n = 6), group 3—hyperthyroid-spinal intact (n = 6), and group 4—hyperthyroid-spinal tx (n = 6). Ejaculatory responses were recorded before and 30 minutes after intraperitoneal administration of 5 mg/kg PCA. Main Outcome Measures During the operations, seminal vesicle (SV) catheterization and bulbospongiosus (BS) muscle dissections were performed in all rats to demonstrate SV pressure (SVP) BS electromyographic (EMG) activity changes. Results Following PCA administration SVP tonic amplitude, SV phasic contraction (SVPC) frequency, SVPC maximal amplitude, and BS EMG area under curve values were higher in hyperthyroid intact rats than in control intact rats. The time interval between PCA administration and first ejaculation of hyperthyroid intact rats were significantly shorter than control intact rats (261 ± 7.30 seconds vs. 426 ± 49.6 seconds, P = 0.008). All of the changes in the ejaculatory parameters that were induced by hyperthyroidism were completely resolved after spinal transections at the T8-T9 level in group 4. Conclusion In this study, we confirmed the recent data that hyperthyroidism affects both the emission and expulsion phases of ejaculation. The changes that were induced by hyperthyroidism on ejaculatory physiology probably take place in the supraspinal centers above T8 level.

Topic: Hormonal and reproductive studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
SH1632251.08FU

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.

Topic: Peanut Plant Research Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
A FIFTY-TWO-WEEK CHRONIC TOXICITY STUDY OF HALOPREDONE ACETATE (THS-201) IN DOGS

In order to evaluate the long-term-safety of halopredone acetate (THS-201: 17 alpha, 21-diacetoxy-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1, 4-pregnadiene-3, 20-dione), a 52-week chronic toxicity study was performed on the basis of its local accumulation in dogs. In doses of 0.1, 0.5 and 2.5 mg/kg, THS-201 was injected into the right knee joint in both sexes of dogs every 2 weeks for 39 weeks and withdrawn for 13 weeks. In this study, the below slight local changes were observed in both sexes of dogs treated with 2.5 mg/kg/2 weeks of THS-201: focal loss of hair of the injection site, lesser stain in cartilage matrix of articular cartilage and meniscus in light microscopic examinations, and irregular thickness and elongation of collagen fibers, roughness of fibrous density and decrement of proteoglycans in electron microscopic examinations. In conclusion, systemic adverse effects were not observed in any dogs treated with THS-201.

Topic: Morinda citrifolia extract uses
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Digital Business Transformation: Exploration of the Use of Erp Based Private Cloud to Improve Managing System in the Company (Case Study on One of Public Company in Indonesia)

This study aims to analyze the existence of the company so as not to be disrupted in the era of digital transformation that presents various innovative advanced technologies in one of public company in Indonesia, which is a manufacturing company, has integrated the systems with the ERP-based private cloud through an intranet network that provides real-time information with data-driven market growth orientation. This research uses a qualitative method with an exploratory descriptive through case study and interviews, by the DTOE Framework and the ABC Model. The results show how the company continues to create alternative strategies on a regular basis with the help of technologies that can minimize risk and improve data security, that operational processes can be executed effectively and accelerate the presentation of the flow of the information faster and accurately as a basis for improving the company's decision-making process.

Topic: SMEs Development and Digital Marketing
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
Nanostructure lipid carriers enhance alpha-mangostin neuroprotective efficacy in mice with rotenone-induced neurodegeneration

Neurodegenerative disease, for instance, Parkinson's disease (PD), is associated with substantia nigra dopaminergic neuronal loss with subsequent striatal dopamine reduction, leading to motor deficits. Currently, there is no available effective therapy for PD; thus, novel therapeutic agents such as natural antioxidants with neuroprotective effects are emerging. Alpha-mangostin (αM) is a xanthone derivative compound from mangosteen peel with a cytoprotective effect depicted in neurodegenerative disease models. However, αM has low aqueous solubility and low biodistribution in the brain. Nanostructured lipid carriers (NLC) have been used to encapsulate bioactive compounds delivered to target organs to improve the oral bioavailability and effectiveness. This study aimed to investigate the effect of αM and αM encapsulated in NLC (αM-NLC) in mice with rotenone-induced PD-like neurodegeneration. Forty male ICR mice were divided into normal, PD, PD + αM, and PD + αM-NLC groups. Vehicle, αM (25 mg/kg/48 h), and αM-NLC (25 mg/kg/48 h) were orally administered, along with PD induction by intraperitoneal injection of rotenone (2.5 mg/kg/48 h) for 4 consecutive weeks. Motor abilities were assessed once a week using rotarod and hanging wire tests. Biochemical analysis of brain oxidative status was conducted, and neuronal populations in substantia nigra par compacta (SNc), striatum, and motor cortex were evaluated using Nissl staining. Tyrosine hydroxylase (TH) immunostaining of SNc and striatum was also evaluated. Results showed that rotenone significantly induced motor deficits concurrent with significant SNc, striatum, and motor cortex neuronal reduction and significantly decreased TH intensity in SNc (p < 0.05). The significant reduction of brain superoxide dismutase activity (p < 0.05) was also detected. Administrations of αM and αM-NLC significantly reduced motor deficits, prevented the reduction of TH intensity in SNc and striatum, and prevented the reduction of neurons in SNc (p < 0.05). Only αM-NLC significantly prevented the reduction of neurons in both striatum and motor cortex (p < 0.05). These were found concurrent with significantly reduced malondialdehyde level and increased catalase and superoxide dismutase activities (p < 0.05). Therefore, this study depicted the neuroprotective effect of αM and αM-NLC against rotenone-induced PD-like neurodegeneration in mice. We indicated an involvement of NLC, emphasizing the protective effect of αM against oxidative stress. Moreover, αM-NLC exhibited broad protection against rotenone-induced neurodegeneration that was not limited to nigrostriatal structures and emphasized the benefit of NLC in enhancing αM neuroprotective effects.

Topic: Natural Compound Pharmacology Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Temperature Prediction Using Multivariate Time Series Deep Learning in the Lining of an Electric Arc Furnace for Ferronickel Production

The analysis of data from sensors in structures subjected to extreme conditions such as the ones used in smelting processes is a great decision tool that allows knowing the behavior of the structure under different operational conditions. In this industry, the furnaces and the different elements are fully instrumented, including sensors to measure variables such as temperature, pressure, level, flow, power, electrode positions, among others. From the point of view of engineering and data analytics, this quantity of data presents an opportunity to understand the operation of the system under normal conditions or to explore new ways of operation by using information from models provided by using deep learning approaches. Although some approaches have been developed with application to this industry, it is still an open research area. As a contribution, this paper presents an applied deep learning temperature prediction model for a 75 MW electric arc furnace, which is used for ferronickel production. In general, the methodology proposed considers two steps: first, a data cleaning process to increase the quality of the data, eliminating both redundant information as well as atypical and unusual data, and second, a multivariate time series deep learning model to predict the temperatures in the furnace lining. The developed deep learning model is a sequential one based on GRU (gated recurrent unit) layer plus a dense layer. The GRU + Dense model achieved an average root mean square error (RMSE) of 1.19 °C in the test set of 16 different thermocouples radially distributed on the furnace.

Topic: Metallurgical Processes and Thermodynamics
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Teacher as Conceptual Artist

Abstract Teachers in arts education frequently struggle with their professional identity. When asked, arts teachers often answer that they believe that their main responsibility is education at the expense of understanding themselves as artists. The Mexican‐American artist and teacher Jorge Lucero questions whether an occupation as teacher necessarily impedes a creative practice. The finding that both progressive pedagogy and conceptual art share certain characteristics forms the basis for his concept of ‘teacher as conceptual artist’. In short, Lucero proposes that a teacher’s practice, in and beyond the classroom, simultaneously can be his or her creative practice. This qualitative intervention study explored whether or not the concept of teacher as conceptual artist holds the possibility to narrow down the gap between teacher and artist identities. The intervention consisted of a three‐day project led by Lucero in which nine arts teacher students were familiarised with modes of operation as a conceptual artist. In the three following months, these students implemented lessons in primary and secondary education based on those modes. Prior to the project, ‘elicitation‐interviews’ were used to explore how students perceived their professional identity and at the end of project semi‐structured interviews were conducted. The findings suggest that through the modes of operation as a conceptual artist, students who mainly identified as an artist were able to integrate a teacher identity in their artist identity, but the modes of operation also gave students who withheld their artist identity from the classroom an opportunity to live their artist identity in the classroom.

Topic: Art Education and Development
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Data from Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study

&lt;div&gt;AbstractPurpose:&lt;p&gt;The Breast Cancer Index (BCI) &lt;i&gt;HOXB13/IL17BR&lt;/i&gt; (H/I) ratio predicts benefit from extended endocrine therapy in hormone receptor–positive (HR&lt;sup&gt;+&lt;/sup&gt;) early-stage breast cancer. Here, we report the final analysis of the Trans-aTTom study examining BCI (H/I)'s predictive performance.&lt;/p&gt;Experimental Design:&lt;p&gt;BCI results were available for 2,445 aTTom trial patients. The primary endpoint of recurrence-free interval (RFI) and secondary endpoints of disease-free interval (DFI) and disease-free survival (DFS) were examined using Cox proportional hazards regression and log-rank test.&lt;/p&gt;Results:&lt;p&gt;Final analysis of the overall study population (&lt;i&gt;N&lt;/i&gt; = 2,445) did not show a significant improvement in RFI with extended tamoxifen [HR, 0.90; 95% confidence interval (CI), 0.69–1.16; &lt;i&gt;P&lt;/i&gt; = 0.401]. Both the overall study population and N0 group were underpowered due to the low event rate in the N0 group. In a pre-planned analysis of the N&lt;sup&gt;+&lt;/sup&gt; subset (&lt;i&gt;N&lt;/i&gt; = 789), BCI (H/I)-High patients derived significant benefit from extended tamoxifen (9.7% absolute benefit: HR, 0.33; 95% CI, 0.14–0.75; &lt;i&gt;P&lt;/i&gt; = 0.016), whereas BCI (H/I)-Low patients did not (−1.2% absolute benefit; HR, 1.11; 95% CI, 0.76–1.64; &lt;i&gt;P&lt;/i&gt; = 0.581). A significant treatment-to-biomarker interaction was demonstrated on the basis of RFI, DFI, and DFS (&lt;i&gt;P&lt;/i&gt; = 0.037, 0.040, and 0.025, respectively). BCI (H/I)-High patients remained predictive of benefit from extended tamoxifen in the N&lt;sup&gt;+&lt;/sup&gt;/HER2&lt;sup&gt;−&lt;/sup&gt; subgroup (9.4% absolute benefit: HR, 0.35; 95% CI, 0.15–0.81; &lt;i&gt;P&lt;/i&gt; = 0.047). A three-way interaction evaluating BCI (H/I), treatment, and HER2 status was not statistically significant (&lt;i&gt;P&lt;/i&gt; = 0.849).&lt;/p&gt;Conclusions:&lt;p&gt;Novel findings demonstrate that BCI (H/I) significantly predicts benefit from extended tamoxifen in HR&lt;sup&gt;+&lt;/sup&gt; N&lt;sup&gt;+&lt;/sup&gt; patients with HER2&lt;sup&gt;−&lt;/sup&gt; disease. Moreover, BCI (H/I) demonstrates significant treatment to biomarker interaction across survival outcomes.&lt;/p&gt;&lt;/div&gt;

Topic: Breast Cancer Treatment Studies
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Usamaro Takakura (1867–1944), Japanese pioneer nemertean researcher

Usamaro Takakura (1867–1944), a pioneer Japanese specialist on nemerteans (phylum Nemertea), established 14 new species and one new genus, Coeia. This paper gives a brief outline of his life and publications, together with the list of his new taxa, the type materials for which are all lost.

Topic: Marine Biology and Ecology Research
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Early Childhood Education: Study on Occupational Safety and Health Knowledge among Elementary School Students

The high number of work accidents in Indonesia requires handling efforts from various indirect aspects; one of the efforts is safety and health education in the student curriculum. A preliminary study of this research aims at identifying the hazard and risk factors in the schools, analyzing the leve

Topic: Public Health and Nutrition
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Improved Production of Sublancin 168 Biosynthesized by<i>Bacillus subtilis</i>168 Using Chemometric Methodology and Statistical Experimental Designs

Sublancin 168, as a distinct S-linked antimicrobial glycopeptide produced by Bacillus subtilis 168, is effective in killing specific microorganisms. However, the reported yield of sublancin 168 is at a low level of no more than 60 mg from 1 L fermentation culture of B. subtilis 168 by using the method in the literature. Thus optimization of fermentation condition for efficiently producing sublancin 168 is required. Here, Box-Behnken design was used to determine the optimal combination of three fermentation parameters, namely, corn powder, soybean meal, and temperature that were identified previously by Plackett-Burman design and the steepest ascent experiment. Subsequently, based on the response surface methodology, the quadratic regression model for optimally producing sublancin 168 was developed, and the optimal combination of culture parameters for maximum sublancin 168 production of 129.72 mg/L was determined as corn powder 28.49 g/L, soybean meal 22.99 g/L, and incubation temperature 30.8°C. The results showed that sublancin 168 production obtained experimentally was coincident with predicted value of 125.88 mg/L, and the developed model was proved to be adequate, and the aim of efficiently producing sublancin 168 was achieved.

Topic: Enzyme Production and Characterization
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Thrombotic Microangiopathy in the Postpartum Period (Literature Review, Clinical Case Report)

Introduction. Thrombotic microangiopathy (TMA) is a heterogeneous group of diseases that, in the presence of endothelial damage, can lead to microvascular thrombosis, secondary platelet consumption, mechanical hemolysis and ischemic end-organs damage. Such triad of symptoms as acute kidney injury (AKI), microangiopathic hemolysis and thrombocytopenia may also accompany some pregnancy-specific conditions (severe preeclampsia/HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count), acute fatty liver disease of pregnancy (AFLP), and conditions not related to pregnancy, but triggered by it (catastrophic antiphospholipid syndrome (CAPS), lupus flare. The aim of the study. To review the current literature devoted to the problem of thrombotic microangiopathy, to demonstrate on a clinical case a step-by-step differentiated approach to the diagnosis of the type of thrombotic microangiopathy causing acute kidney injury in the postpartum period, and to describe modern methods of treatment of these diseases. Results. The classical types of TMA are thrombotic thrombocytopenic purpura (TTP) and typical hemolytic uremic syndrome (HUS), also known as enterohemorrhagic Shiga toxin-producing Escherichia coli (STEC)-associated HUS (STEC-HUS). Pathophysiologically, all forms of TMA involve complement-mediated endothelial cell damage, which mainly affects the capillary zone of the kidney. Pregnancy can trigger atypical HUS (aHUS) or TTP. The article describes the clinical case of a 37-year-old woman who developed AKI following a complicated delivery. A turn-based differential diagnosis of aHUS was performed. Unwarranted discontinuation of the targeted therapy with Eculisumab led to the development of chronic renal failure Conclusions. Thrombotics microangiopathy are the life-threatening conditions rarely seen in pregnancy making its early recognition difficult. As thrombotics microangiopathy require urgent treatment, plasmapheresis should be started as soon as they are suspected, followed by targeted therapy (Eculisumab, Rituximab) after the confirmation of the diagnosis. This may contribute to reducing maternal morbidity and mortality rates.

Topic: Complement system in diseases
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Feasibility and Clinician Perspectives of the Visual Symptoms and Signs Screen

Background: The Visual Symptoms and Signs Screen (V-SASS) is a tool to identify vision deficits and facilitate referrals to vision specialists. The study objectives were to determine feasibility and clinician perspectives of the V-SASS. Methods: Prospective, multisite study with 141 new-onset stroke participants. After V-SASS administration, feasibility and predictive success were assessed. Results: The V-SASS identified vision symptoms and signs with high feasibility (&gt;75%). Of those who screened positive, 93.1% had deficits in visual function or functional vision. Conclusions: The V-SASS was found to be feasible in multiple settings and accurately identify vision deficits and appropriately trigger vision referrals.

Topic: Spatial Neglect and Hemispheric Dysfunction
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Haematopoietic stem cell transplantation in children with inborn errors of immunity: A single centre experience

Abstract This study retrospectively analyzed the outcomes of 61 pediatric patients with inborn errors of immunity (IEI) who underwent hematopoietic stem cell transplantation (HSCT) between 2011 and 2023. Patients were categorized into primary immunodeficiency disorders (PIDD), primary immune dysregulation disorders (PIRD), and congenital defects of phagocyte number or function (CDP). Median ages at diagnosis and HSCT were 9 and 30 months, respectively. With a median follow‐up of 51 months, the overall survival (OS) was 70%, with a 100‐day post‐transplant OS of 80%. Transplant‐related mortality (TRM) was 29%, with rates of 42%, 22.5%, and 27% for PIRD, PIDD, and CDP, respectively. This study highlights the importance of early diagnosis and HSCT in improving survival for IEI patients, while also emphasizing the need for continuous improvements in transplant protocols to minimize TRM and enhance quality of life.

Topic: Immunodeficiency and Autoimmune Disorders
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Teacher training in computer education

It is the intent of this paper to describe a computer education course now available for pre-and in-service secondary school mathematics teachers at the Pennsylvania State University. The development of the present syllabus has been evolutionary and extends back over a period of years, predating the IFIP Outline Guides (4), but at the same time speaking to many of the same considerations.

Topic: Information Systems Education and Curriculum Development
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Follicular eruptions of atopic dermatitis.

Most of 251 patients with atopic dermatitis had itchy follicular papules, mainly on the lateral parts of the trunk rather than on the extensor surfaces of the extremities. Biopsy specimens of the papules showed spongiosis and vesicle formation at the upper portion of the follicles which were surrounded and penetrated by mononuclear cells. Such an inflammatory change was absent in the surface epidermis adjacent to the follicles. It is suggested that the follicular papule is an essential lesion, probably a first visible eruption of atopic dermatitis.

Topic: Skin and Cellular Biology Research
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences