jimnoneill/paper-to-field-training huggingface dataset:
Umbilical cord blood banks. Ethical aspects. Public versus private banks.

The creation of umbilical cord blood (UCB) banks raises interesting medical, social, economic and ethical issues. This paper reviews the ethical problems specifically. In this respect, it evaluates: a) whether there are advantages to the use of UCB compared to bone marrow, b) whether or not it is ethical to create UCB banks, c) whether their creation is ethically acceptable in terms of their clinical usefulness or d) the use made of them for therapeutic purposes, and finally e) whether their creation is ethically justified from a cost/profitability point of view. We focus primarily on evaluating the ethical controversy between public and private banks, particularly on whether it is ethical to bank autologous blood in private UCB banks, on the basis of its limited possibilities for use by the cord blood donor. We can conclude that, from an ethical point of view, autologous blood banks have limited acceptance among specialised researchers, scientific societies and other public institutions. Therefore, we believe that it is ethically more acceptable to support the creation of public UCB banks for medical and social reasons and, above all, based on the principle of justice and human solidarity. Nevertheless, there is no definitive ethical argument why a couple, according to their autonomy and freedom, cannot bank their child's UCB in a private bank. An equally acceptable solution could be the creation of mixed banks, such as that proposed by the Virgin Health Bank or like the Spanish system where autologous samples can be stored in public banks but with the proviso that if at any time the stored sample is required by any person other than the donor, it would have to be given to them.

Topic: Palliative Care and End-of-Life Issues
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
The effect of local anaesthetics on lipolysis in fat-cells

Research Article| November 01 1972 The effect of local anaesthetics on lipolysis in fat-cells K Siddle; K Siddle 1Department of Chemical Pathology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: This Site PubMed Google Scholar C N Hales C N Hales 1Department of Chemical Pathology, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 130 (1): 34P. https://doi.org/10.1042/bj1300034P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation K Siddle, C N Hales; The effect of local anaesthetics on lipolysis in fat-cells. Biochem J 1 November 1972; 130 (1): 34P. doi: https://doi.org/10.1042/bj1300034P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Diet and metabolism studies
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
PENINGKATAN EFISIENSI PEMUPUKAN FOSFOR PADA ULTISOL DENGAN MENGGUNAKAN ABU TERBANG BATUBARA

Ultisol is one type of soil that has a very wide distribution in Indonesia, but the use of this soil faces many obstacles. The main problem in ultisol utilization is the low availability of phosphorus (P) and the low absorption efficiency. Coal fly ash (CFA) is a material that can overcome these problems. The objective of this study was to examine the effect of Application CFA on several soil chemical properties (pH, exchangeable Al, exchangeable Ca and available P), plant growth, yield, and absorption efficiency of P fertilizer. This study used a completely randomized factorial design consisting of two factors. The first factor was CFA that consisted of three levels of treatment, namely: A0 = 0 t ha-1 or without CFA, A1 = 40 t CFA ha-1, A2 = 80 t CFA ha-1. The second factor was P fertilizer that consisted of four levels of treatment, namely: P0 = 0 kg ha-1, P1 = 30 kg P ha-1, P2 = 60 kg P ha-1 and P3 = 90 kg P ha-1. The results of the study showed that the application of 80 t CFA ha-1 increased the pH by 13.41%, reduced exchangeable Al by 59.53% and increased exchangeable by Ca 192.66% compared to control. The combination 80 t CFA ha-1 and 90 kg P ha-1 increased available P by 986.79% compared to control. The application of 80 t CFA ha-1 resulted in the highest total plant dry weight and total P uptake. The treatment resulted in total plant dry weight of 172.96 g and total P uptake of 187.62 mg plant-1, increased 62.39% and 100.21% respectively compared to the control. The application of 90 kg P fertilizer ha-1 resulted in the highest total dry weight of maize, and total P uptake, namely 167.49 g and 174.39 mg plant-1, respectively, which means that the total plant dry weight increased by 51.00% and the total uptake P increased 69.79% compared to control. The highest seed dry weight was obtained in the combination of 80 t CFA ha-1 and 90 kg P ha-1, namely 39.33 g, an increase of 715.53% compared to the control. The combination of 40 t CFA ha-1 and 30 kg P ha-1 resulted in the highest absorption efficiency of P fertilizer, namely 30.43%. This means that in this treatment, maize can absorb 30.43% of the applied P fertilizer.

Topic: Coal and Its By-products
Subfield: Geochemistry and Petrology
Field: Earth and Planetary Sciences
Domain: Physical Sciences
The Influence of Electromagnetic Field on Honey Bee Workers – Review Paper

The environment in which insects live, especially honey bees, which are natural pollinators, is increasingly polluted by electromagnetic fields. The impact of the anthropogenic electromagnetic field on bees depends on its frequency and intensity. A wide range of these variables have different effects on bees. This is manifested by changes in physiology, different behaviors and energy absorption by the bee's body. The article reviews these effects in relation to: low-frequency electric fields at a frequency of 50 Hz, electromagnetic fields generated by mobile telecommunications networks and high-frequency electric fields (2 ÷ 240) GHz. Most studies reported an adverse effect of the field on honey bee colony populations. Additionally, a method of protecting bees and hives against infection using an electromagnetic field, i.e. ultraviolet UV-C radiation, was presented. The paper presents a synthetic assessment of the impact of the electromagnetic field on honey bee workers based on a literature review.

Topic: Insect and Arachnid Ecology and Behavior
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
THEORY AND PRACTICE OF COMPUTER AIDED MANUFACTURING ENGINEERING (CAME)

Prevalent area of exploitation of CAM (Computer Aided Manufacturing) systems is computer aided program creating for NC production equipment. However, CAM systems do not sufficiently cover all periods of production process and due to this, the necessity to define the systems of Computer Aided Manufacturing Engineering - CAME is obvious. CAME is a subsystem of the system CIM including the computer aided systems of all activities connected with realization of product manufacturing. Computer technology equipped with suitable software is advantageously used in various branches of practice at present time. It is difficult to imagine the development and production of new products in modern enterprise without exploitation of appropriate computer aided systems. Most of present CA systems are mainly determined and used in the area of computer design and constructing of new products, but only complete application of these modern computer technologies to all periods of product design and manufacturing, can bring the maximum profit for the enterprise. CAM (Computer Aided Manufacturing) systems are mostly used in practice in the area of production in relation to computer support. However, prevalent area of exploitation of these systems is computer aided of program creating for NC production equipment, what represents, from the point-of-view of completed production process, only one of its part. There are also others processes of product manufacturing process for example: automated work-in-process transport and product storing, automated handling with the products, performing the measurements in automated inspection stands, etc. Following these facts, CAM systems do not sufficiently cover all stages of production process and so it is necessary to define the systems of Computer Aided Manufacturing Engineering - CAME.

Topic: Manufacturing Process and Optimization
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Technical manual and user guide for the surface panel code: PALISUPAN

This report describes the theoretical background and the method of use of a general purpose lifting surface panel code Palisupan. This code, originally developed in Occam for use across arrays of transputers, has been rewritten in ANSI C and a serial version is available for use on Unix based machines. The code uses dynamic memory allocation to maximise the available problem size for a given computational environment. The two available methods for preparing geometry definition files are described as are the production of various types of post-processing information. A section describes the importance of the validation process. An exercise in the form of a validation tutorial introduces the user to the limitations of three-dimensional potential flow analysis using a surface panel code. A final section describes an assignment for users to implement in order to develop increased familiarity with the solution of a practical design problem. In this case the analysis of yacht keel-bulb hydrodynamic performance.

Topic: Ship Hydrodynamics and Maneuverability
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
The Intersection of Race, Culture, Language, and Disability

To date, few researchers have sought to examine the effect of issues of race, culture, language, and disability, let alone to look specifically at the intersection of these issues, as it relates to special education identification, special education service delivery, and students of color’s access to an equitable education. Thus, this article will attempt to help urban education researchers and educators understand (a) why the intersection of race, culture, language, and disability is an urban education issue; (b) how issues of race, culture, language, and disability affect students’ and their families’ quest for an equitable education; (c) how to advocate for and provide culturally responsive services to racially, culturally, linguistically, and economically diverse students and their families; and (d) the implications of the intersection of race, culture, and disability for urban education practice, research, and policy.

Topic: Education Discipline and Inequality
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Characterization of the Role of CXCL10 and CXCR3 in Breast Cancer

Lymphocytic infiltration is a feature of basal breast cancer tumors. CXCL10 is a chemokine that was found expressed higher in basal tumor RNA compared to estrogen receptor positive tumor RNA. Both CXCL10 and its receptor CXCR3 were expressed in familial breast cancer tissues, a proportion of which have a basal phenotype. CXCL10 expression was associated with lymphocytic infiltration, and with CXCR3 expression. CXCL10 ligand and receptor were overexpressed individually or together in the human MCF7 cell line. Recombinant human CXCL10 was found to dose dependently decrease cell proliferation. CXCR3 and CXCL10-CXCR3 expressing cells had the potential for increased migration independent of CXCL10 concentration. Co-expression of both genes increased proMMP-2 levels, and conditioned media from one of these clones chemoattracted more of the CXCR3 clones, CXCL10-CXCR3 clones, and CD4+ T-lymphocytes. CXCL10 neutralization suggested that CXCL10 could play a role in this chemoattraction, though it is likely not the only factor involved.

Topic: Chemokine receptors and signaling
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation

<title>Abstract</title> Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is a destructive condition that constitutes a main cause of death in newborns. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. Results: Here, we established hypoxic-ischemic (HI) injury and primary cortical neurons subjected to oxygen-glucose deprivation (OGD) to mimic HIE model in-vivo and in - vitro . Zea-longa scores, Triphenyte-trazoliumchloride (TTC) staining the Terminal Deoxynucleotidyl Transferased Utp Nick End Labeling (tunel) and immunofluorescent staining were used to detect the neurological injuries after HI. Then the expression of Cytochrome c oxidase subunit 5a (COX5A) was determined by immunohistochemistry, western blotting (WB) and quantitative real time Polymerase Chain Reaction (qRT-PCR) techniques. Moreover, HSV-mediated COX5A over-expression virus was administrated in - vitro to explore the role of COX5A in OGD neurons. Subsequently, the underlying mechanism was predicted by GeneMANIA and confirmed by WB and qRT-PCR. The results showed that HI induced a severe behavioral dysfunction, brain infarction, and cell apoptosis as well as obvious neuron loss in neonatal rats, in corresponding to the decrease on the expression of COX5A in both sides of the brain . What’s more, COX5A over-expression significantly promoted the neuron survival, reduced the apoptosis rate, and markedly increased the neurites length after OGD. Moreover, Triosephosephate isomerase (TPI) was predicted as physical interactions with COX5A, and COX5A over-expression largely increased the expressional level of TPI. Conclusions: Together, these data suggest that COX5A plays an important role in promoting neurological recovery after HI, and this process is related to TPI up-regulation.

Topic: Neonatal and fetal brain pathology
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Toward a Critical Analysis of Role

The Frankfurt School distinguishes role as a sociological concept from role as a phenomenon, and the question becomes what role as a phenomenon may be like. On the basis of an argument adapted from Simmel and Schutz, the hypothesis is raised that roles are everyday schemes based on processes of typification and idealization. It is argued that the latter allows for the intrusion of power into role structures, and, in fact, the use of roles as the expression of political control. Thus, not only role theory (as traditional theory in Horkheimer's terms) but also society's role structures invite the criticisms of critical sociologists who want to contribute through their conceptual work to the liberation of individuals from the constraints of their repressive society.

Topic: Critical Theory and Philosophy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Developing HIV Prevention Interventions for Emerging Adult MSM With a History of Being Bullied: A Qualitative Study

The experience of being bullied in childhood or adolescence affects health into adulthood and is a public health crisis. Particularly affected are sexual minority young adults who are at the greatest risk for severe and violent bullying, HIV seroconversion, and onset of a substance use disorder. Although the scholarly work in the area of bullying victimization has made great gains over the past few years via improved sampling and methodological rigor, most of the focus of health research in this area has been on prevention efforts. The purpose of the current study was to inform the development of a transdiagnostic integrated treatment platform that will focus on mental and physical health outcomes that include sexual risk taking and substance abuse. This study involved conducting four focus groups with HIV-uninfected gay and bisexual men, aged 18 to 26 years, in order to examine treatment needs and preferences and further develop an evidence-based intervention. Four themes emerged from the analysis of transcripts: (a) learning about bullying and psychopathology, (b) coping with bullying, (c) experiencing psychopathology as a consequence of bullying, and (d) tailoring psychosocial interventions to address health sequelae linked with bullying. These themes provided a solid foundation to develop and test an intervention to address key health risks among men who have sex with men (MSM) with a history of being bullied and recent sexual risk taking and substance abuse.

Topic: HIV/AIDS Research and Interventions
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Integrative Action Process in the Perspective of Globalization

Transformations of knowledge and collaboration with international R&amp;D experts are becoming increasingly common and an important part of international competitiveness. The object of Integrative Action is to integrate the three statutory tasks set for universities of applied sciences in Finland: education, research and development, and regional development. The constructive research question addressed in this article is: What are the constructions and models contributing to international and global activities, which are used in implementation and actualization by Finnish universities of applied sciences? The case in this article is Laurea University of Applied Sciences. The new proposition involves the Integrative Action model, with its elements and its applications from the perspective of globalization. The main contributions of the integrative action and process model are 1) the creation of a sustainable and linear framework for cyclic innovation activities and 2) the implementation of regional development and globalization perspectives Laurea University of Applied Sciencesâ?? everyday activities. The proposed models were applied and tested in higher education.

Topic: University-Industry-Government Innovation Models
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Rubin: New Bulgarian red pepper variety for grinding

The new variety for grinding was bred at the Maritsa Vegetable Crops Research Institute, Plovdiv, Bulgaria. The plants form mid-high about 60 cm indeterminate bush with 20 -21 cm long stem, 2 - 3 comparatively well-leafed branches and on average 16 red fruits. Rubin differed by the pendant fruits and easier picking from the other two Bulgarian varieties Gorogled 6 and Buketen 50. The fruit length was on average 9-11 cm, the diameter-approximately 2 cm and the fruit weight is on average 14 g. Rubin exceeds in dry matter yield Gorogled 6 and Buketen 50 by 54 % and 111%, respectively. The dry matter content at the optimal harvesting term was about 25 % and the pigments were 170 - 220 ASTA. The new variety did not differ in total pigment content from Gorogled 6 and Buketen 50.

Topic: Piperaceae Chemical and Biological Studies
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Noise and kanamycin interaction in the guinea pig cochlea

Guinea pigs were exposed to octave band (0.1, 2, or 8 kHz) or broad-band noise at 90, 100, and 106 dB SPL, eight hours daily for seven days, while receiving kanamycin 100 mg/kg daily s. c. Controls were subjected to noise exposure or kanamycin injection only. Cochlear injuries were assessed electrophysiologically in terms of reduction in microphonic (CM) and neural (N1) potentials, and histopathologically in terms of the location and extent of hair cell loss seen in surface preparations of Corti's organ and recorded in cytocochleograms. Potentiation between noise and kanamycin was seen only after exposures at 100 dB or more, and then not in all animals. With 0.5-kHz exposures even at 112 dB, affecting mainly turn 3, there was no indication of enhancement of the injury by kanamycin, which has its major site of action in the basal turn. It appears that for potentiation to occur the noise and the antibiotic must act on the same region of the cochlea. [Supported by NIH-NIEHS contract No. 1-ES-2-2110 and NM Program Project Grant 05785.]

Topic: Hearing, Cochlea, Tinnitus, Genetics
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Revised supplementary Table 2 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

&lt;p&gt;Supplementary Table 2. The most important miRNA predicted as potential regulators of Neuroactive ligand-receptor interaction signature genes.&lt;/p&gt;

Topic: Chromatin Remodeling and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Thermal Hydrolysis of Sludge Counteracts Polystyrene Nanoplastics-Induced Stress during Anaerobic Digestion

Microplastics (MPs)/nanoplastics (NPs) have been widely detected in wastewater treatment plants (WWTPs). They are captured mainly by sludge and unavoidably move into the anaerobic digestion (AD) process. Recent studies suggested that MPs/NPs could induce oxidative stress to the microbiome in digesters. The thermal hydrolysis process (THP) has been implemented for sludge pretreatment in many full-scale WWTPs. To date, there is limited knowledge about how THP can influence MPs/NPs-induced stress during AD. This study systematically investigated the impact of THP (80 and 160 °C) on AD of sewage sludge exposed to different levels (50–150 μg/L) of polystyrene nanoplastics (PsNPs), one of the most found MPs/NPs in WWTPs. Compared to the control, higher PsNPs levels of 100 and 150 μg/L decreased methane yields by 17.98 and 29.34%, respectively. Moreover, reactive oxygen species (ROS) levels increased by 17.18 and 34.84%. Our results demonstrated that THP counteracted the suppression of methane production imposed by such PsNPs concentrations, with decreased ROS levels. Also, THP reduced antibiotic resistance gene (ARG) propagation that can be encouraged by PsNPs, thus minimizing the ARG transmission risks of digestate biosolids. These findings suggest that THP holds a high promise to further develop as a remediation method for MPs/NPs in WWTPs.

Topic: Microplastics and Plastic Pollution
Subfield: Pollution
Field: Environmental Science
Domain: Physical Sciences
The Bhagavad-Gita for the Modern Reader: History, interpretations and philosophy

"What is the Bhagavad-Gita? Is it just a religious text? When was it composed? How relevant is it to the modern world? This book answers these foundational questions and more. It critically examines the Bhagavad-Gita in terms of its liberal, humanist and inclusive appeal, bringing out its significance for both present times and novel applications. The author elaborates the philosophy underlying the text as well as its ethical and spiritual implications. He also responds to criticisms that have been levelled against the text by Ambedkar, D.D. Kosambi and, more recently, Amartya Sen. With additional material including chapter summaries of the Bhagavad-Gita, the second edition of the volume proposes new ways of utilising the text in diverse fields, such as business and management and scientific research. Eclectic and accessible, this work will be of interest to scholars of philosophy, religion, history, business and management studies, as well as the general reader"--

Topic: Indian History and Philosophy
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences