jimnoneill/paper-to-field-training huggingface dataset:
Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors

The aim of this study was to determine risk factors for adverse events (AE)-related treatment discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor (PI)-based therapy. We included all patients who initiated treatment with PI-based therapy at a Brazilian university hospital between November 2013 and December 2014. We prospectively collected data from medical records using standardized questionnaires and used Epi Info 6.0 for analysis. Severe anemia was defined as hemoglobin ≤8.5 mg/dL. We included 203 patients: 132 treated with telaprevir (TVR) and 71 treated with boceprevir (BOC). AE-related treatment discontinuation rate was 19.2% and anemia was the main reason (38.5%). Risk factors for treatment discontinuation were higher comorbidity index (OR=1.85, CI=1.05-3.25) for BOC, and higher bilirubin count (OR=1.02, CI=1.01-1.04) and lower BMI (OR=0.98, CI=0.96-0.99) for TVR. Severe anemia occurred in 35 (17.2%) patients. Risk factors for this outcome were lower estimated glomerular filtration rate (eGFR; OR=0.95, CI=0.91-0.98) for patients treated with TVR, and higher comorbidity index (OR=2.21, CI=1.04-4.67) and ribavirin dosage (OR=0.84, CI=0.72-0.99) for those treated with BOC. Fifty-five (57.3%) patients treated with TVR and 15 (27.3%) patients treated with BOC achieved sustained virological response (SVR). Among patients who received TVR and interrupted treatment due to AE (n=19), only 26.3% (n=5) achieved SVR (P=0.003). Higher number of comorbidities, lower eGFR and advanced liver disease are associated with severe anemia and early treatment cessation, which may compromise SVR achievement.

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
ChemInform Abstract: Preclinical Efficacy on GSK‐3 Inhibitors: Towards a Future Generation of Powerful Drugs

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Nuclear Receptors and Signaling
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Effect of nitrogen incorporation to electrical and optical properties of amorphous carbon thin film prepared by thermal CVD

Nitrogen-doped amorphous carbon thin films have been prepared by thermal chemical vapor deposition (CVD) technique at different temperature. The preparation involved argon, camphor and nitrogen as carrier gas, carbon source and dopant respectively. The effects of nitrogen incorporation in the amorphous carbon thin film on electrical and optical properties was characterized by using Advantest R6243 DC Voltage Current Source/Monitor and SemiPro Curve Software and UV-VIS-NIR spectroscopy. The current-voltage (I-V) measurement studies demonstrate that the conductivity increased along the deposition temperature. There are also significant changes in conductivity and optical band gap for doped and undoped thin films.

Topic: Diamond and Carbon-based Materials Research
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Clinical profile and serum homocysteine level in young patients with stroke: a prospective, observational study

Background: According to the WHO, stroke is the second most important cause of death in elderly people with age &gt;60 years and fifth leading cause in the age group of 15 to 59 years. Hyperhomocysteinemia has been linked to increased incidence of ischemic strokes. Thus, the aim of the present study was to assess serum homocysteine levels as an individual risk factor of stroke in young patients.Methods: This was a prospective, cross-sectional, single center study performed in 50 patients admitted in the Department of Medicine, Thanjavur Medical College and Hospital, Thanjavur, over a period of 7 months (i.e., from December 2013 to June 2014). Young patients, aged 1545 years, and diagnosed with stroke were included in the study. Serum homocysteine was measured by fluorescein polarization immunoassay (FPIA). Significant difference between the patients with normal and elevated mean serum homocysteine levels was identified by using unpaired t-test. P value ≤0.05 was considered as statistically significant.Results: Majority of the stroke patients were male (78%). Similarly, male patients dominated the total number of patients with elevated serum homocysteine levels (75%). Thirty-two (64%) patients had an elevated serum homocysteine level. There was a significant difference between the patients with increased homocysteine levels as compared to patients with normal homocysteine levels (p value &lt;0.05). Out of 32 patients with hyperhomocysteinemia, 27 (84.38%) patients had ischemic stroke, 4 (12.50%) had cortical vein thrombosis and 1 (3.12%) had hemorrhagic stroke.Conclusions: Findings of the present study confirm that hyperhomocysteinemia is associated with an increased incidence of stroke in young patients. As healthcare providers, we must stress on prevention of stroke, especially by identifying treatable risk factors.

Topic: Folate and B Vitamins Research
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Additional diagnostic features of mammary analogue secretory carcinoma on cytology

In our article, we report additional cytolorphologic features of MASC. In addition to vacuolated cells/histiocytoid cells and colloid‐like material in the background we noticed nuclear membrane irregularities, nuclear grooving, and hyalinized tissue fragments in the cell block. These additional features can serve as important diagnostic clues in making a diagnosis of MASC on cytology.

Topic: Salivary Gland Tumors Diagnosis and Treatment
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Comment on bg-2023-133

<strong class="journal-contentHeaderColor">Abstract.</strong> Growth of the pioneer grass <em>Miscanthus condensatus</em>, one of the first vegetation to be established on volcanic deposits, is promoted by root-associated fungi, particularly dark septate endophytes (DSE). Fungal taxa within DSE colonize the root of <em>Miscanthus condensatus</em> in oligotrophic <em>Andosol</em>, and their function in plant growth promotion remains largely unknown. We, therefore, comprehensively assessed the composition of the DSE community associated with <em>Miscanthus condensatus</em> root in volcanic ecosystems using the approaches of both metabarcoding (next-generation sequencing) and isolation (culturing). Also, their promotion effects of DSE on plant growth (rice as a proxy) were evaluated by inoculation of core isolates to rice roots. Here, we found: i) 70 % of culturable fungi that colonized <em>Miscanthus condensatus</em> phylogenetically belonged to DSE, ii) 7 orders were identified by both sequencing and culturing methods, and iii) inoculation of DSE isolates (<em>Phialocephala fortinii</em>, <em>P. helvetica</em>, <em>and Phialocephala sp.</em>) validated their effects on rice growth, particularly under an extremely low pH condition (compared to control without inoculation, rice biomass enhanced by 7.6 times after inoculation of <em>P. fortinii</em>). This study helps improve our understanding of the community of <em>Miscanthus condensatus</em>-associated DSE fungi and their functions in promoting plant growth.

Topic: Plant and fungal interactions
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
DYNAMICS OF LONG-TERM CHANGES OF ROUND GOBY POPULATION CHARACTERISTICS ( NEOGOBIUS MELANOSTOMUS PALLAS) OF THE BLACK AND AZOV SEAS

Population characteristics of round goby Neogobius melanostomus from the Black Sea and Azov Seas at the period of 2003 and 2009-2012 years were studied. Decrease of linear and weight growth, as well as changes of morphological and physiological parameters of the animals from both water bodies in the modern period compared to the early 2000s was observed. The probable causes of the annual changes are discussed.

Topic: Food Industry and Aquatic Biology
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification

Abstract Objective The minimal model is used to estimate insulin sensitivity in patients with diabetes, following an intravenous glucose tolerance test (IVGTT). Issues have been reported regarding parameter estimation, including correlation between insulin sensitivity and action parameters. The objective was to reduce these issues, by modifying the input of glucose in the test. Methods Data were available for 24 volunteers following an IVGTT and glucose clamp test. Correlation between parameters was explored using likelihood heatmaps. An integrated glucose–insulin model was used to simulate glucose and insulin concentrations following new glucose inputs. The improved input for the test was selected by finding the minimum inverse of the determinant of the Fisher information matrix. Key findings When the minimal model was fitted to the IVGTT data, there was clear correlation between the insulin parameters. With the glucose clamp, all parameters were correlated and badly estimated. The modified input, a bolus dose followed by constant infusion, resulted in improvement in parameter estimation and reduction in parameter correlation. Conclusions It is possible to reduce the issues with parameter estimation in the minimal model by modifying the glucose input, leading to a simplified test deign and a reduction in the total amount of glucose infused.

Topic: Diabetes Management and Research
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
High levels of C-reactive protein are associated with reduced vagal modulation and low physical activity in young adults

The purpose of this study was to examine the relationship between cardiac autonomic control derived from heart rate variability (HRV), high-sensitivity C-reactive protein (hs-CRP) and physical activity (PA) levels measured using accelerometers. A total of 80 healthy university students volunteered to participate in this study (20.56 ± 0.82 years, 1.36 ± 1.5 mg/L of hs-CRP). The participants were divided into groups based on tertiles of hs-CRP. Analysis of covariance adjusted to PA was used to assess group differences in HRV. Associations between hs-CRP, HRV indices and PA were analyzed using Pearson's correlation. The participants at the highest tertile of hs-CRP (tertile 3) had lower cardiac vagal modulation (SDNN, tertile 1=78.05 ± 5.9,tertile 2=82.43 ± 5.9,tertile 3=56.03 ± 6.1; SD1, tertile 1=61.27 ± 5.3, tertile 2=62.93 ± 5.4, tertile 3=40.03 ± 5.5). In addition, vagal indices were inversely correlated with hs-CRP but positively correlated with PA (SDNN r=−0.320, SD1 r=−0.377; SDNN r=0.304, SD1 r=0.299; P&lt;0.05). Furthermore, the most physically active subjects had lower levels of hs-CRP and the highest levels of vagal modulation.

Topic: Heart Rate Variability and Autonomic Control
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Style and Discourse, with Special Reference to the Text of the Greek New Testament

Book Review| March 01 1986 Style and Discourse, with Special Reference to the Text of the Greek New Testament Style and Discourse, with Special Reference to the Text of the Greek New Testament, E. A. Nida, J. P. Louw, A. H. Snyman and J. v. W. Cronje. Moisés Silva Moisés Silva Search for other works by this author on: This Site Google Journal of Biblical Literature (1986) 105 (1): 170–171. https://doi.org/10.2307/3261151 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Moisés Silva; Style and Discourse, with Special Reference to the Text of the Greek New Testament. Journal of Biblical Literature 1 March 1986; 105 (1): 170–171. doi: https://doi.org/10.2307/3261151 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Biblical Studies and Interpretation
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
International development institutions and the challenges of urbanisation: the case of Jakarta

Urbanisation in the Global South presents numerous challenges for international development institutions. Building from interviews at nine different international development institutions working in Jakarta, Indonesia, this article examines how such institutions approach urban poverty, governance, and collaboration. The case study of Jakarta indicates that urban governance is often fragmented and difficult for such institutions to navigate, making partnership with other, often local, actors and institutions with urban and on-the-ground expertise vital. International development institutions struggle to both address the unique characteristics of distinct urban areas and to develop widely replicable practices, strategies, and platforms for effective partnership and development intervention.

Topic: Socioeconomic Development in Asia
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
MET-6 Neoadjuvant fractionated stereotactic radiotherapy followed by piecemeal resection for metastatic brain tumor

Abstract BACKGROUND: Large brain metastases which require resection are treated with surgery followed by whole brain radiation therapy or postoperative stereotactic radiosurgery (SRS). Recently a novel strategy using neoadjuvant stereotactic radiosurgery (Na-SRS) followed by surgery was reported, demonstrating lower rates of postoperative leptomeningeal dissemination (LMD) and symptomatic radiation necrosis (RN). We treated with neoadjuvant fractionated stereotactic radiotherapy (Na-fSRT) followed by surgery for large brain metastasis with piecemeal resection. METHODS: Twelve patients received Na-fSRT followed by surgery between July 2019 and April 2021. Na-fSRT dose was based on lesion size and was standard dosing. Surgery generally followed within 7 days after radiotherapy. RESULTS: The mean age was 68 years (51–79). Sixteen men and five women. Mean follow-up period was 8.5 months (1–24.9). Primary were lung; 10 (NSCLC; 9, SCLC (recurrence); 1), esophagus; 3, colon; 2, melanoma; 2, kidney; 2 (recurrence1), uterus body; 1, and liver; 1. The median maximum tumor diameter was 3.6 cm (2.6–4.9). Median PTV, GTV volume were 21.7ml, 15.5ml, respectively. The median fSRT dose was 30Gy/5fr, and the median time from fSRT to surgery was 4 days (1–7). As preoperative adverse event, intracranial hypertension and partial seizure grade 2 (CTCAE ver.5) were occurred, but controlled with steroid and osmotic diuretics and anticonvulsant. Grade 3 and more adverse events were not occurred. Gross total removal was performed in 95.2%. Event cumulative incidence as follows: cavity local recurrence 4.8% (subtotal removal case); distant brain failure 33%; LMD 4.8%; and symptomatic RN 0%. The median intracranial progression free survival was 7 months, and median overall survival was 8.4 months. CONCLUSIONS: Na-fSRT followed by piecemeal resection is safety and feasible, and may have therapeutic value for deep large brain metastasis and eloquent lesion. Further prospective investigations in multi-institutional settings are warranted.

Topic: Brain Metastases and Treatment
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Biochemical and behavioral responses in carp fish exposed to tricaine methane sulfonate (MS-222) as anesthetic drug under transport conditions

This study aims to determine the effects of Tricaine methane‐sulfonate (MS-222) at concentration 150mg/l for one hour as an anesthetic agent to reduce the stress conditions during transfer the fish. Forty fish (<em>Cyprinus carpio</em>) were divide in to four groups: the 1<sup>st</sup> is control group (fish without both transfer and anesthesia), the 2<sup>nd</sup> group (fish transfer without anesthesia), the 3<sup>rd</sup> group (fish anesthesia without transfer) and the 4<sup>th</sup> group (fish transfer with anesthesia). The induction time reached to 3 minutes while the recovery time take at lasted for 7 to 10 minutes. Furthermore, the cortisol was significantly decreased in fish serum in both anesthetized groups that were transferred or that were left in the pond without transmission in compare to control groups (both transfer and without transfer fish). The glucose level rose significantly (P <0.05) in the serum of fish in both 3<sup>rd</sup> and 4<sup>th</sup> groups in compare to control groups. There was no difference in hematological parameters (hemoglobin and packed cell volume), blood sodium ion concentration, and enzyme activity represented by Alanine amino transferase in all groups while level of creatinine phosphate was decrease significantly in both groups 2<sup>nd</sup> and 3<sup>ed </sup>in compare to 1<sup>st</sup> group. It can be concluded that tricaine methane‐sulfonate stimulates the recovery and shortens the time of induction and reduces the stress condition caused by fish transport.

Topic: Aquaculture disease management and microbiota
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
How does probability judgment influence contingent valuation method to estimate WTP for natural disaster reduction

Contingent valuation method (CVM) is a widely adopted approach for estimating individuals' willingness to pay (WTP) for public goods. Using national survey data from Japan, this paper examines how the estimated WTP through CVM varies with different risk probabilities and risk information presentations in the context of natural disasters. The findings show that people's WTP is insensitive to the frequency of the disaster and the baseline level of the risk; the commonly observed ratio bias (RB) effect is not significant in our investigation. However, consistent with one similar study before, “group diffusion,” an opposite effect of RB is likely to occur, especially when the disparity between different risk descriptions is large. The result of this paper suggests that WTP may be influenced by the risk information provided and the way risk is framed in communications; therefore, CVM should be cautiously treated through rigorous validity checks when it is used to estimate WTP and risk is an important factor.

Topic: Economic and Environmental Valuation
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
High Effectiveness of Broad Access Direct‐Acting Antiviral Therapy for Hepatitis C in an Australian Real‐World Cohort: The REACH‐C Study

Australia was one of the first countries with unrestricted access to government subsidized direct‐acting antiviral (DAA) therapy for adults with chronic hepatitis C virus. This study assessed real‐world DAA treatment outcomes across a diverse range of Australian clinical services and evaluated factors associated with successful treatment and loss to follow‐up. Real‐world Effectiveness of Antiviral therapy in Chronic Hepatitis C (REACH‐C) consisted a national observational cohort of 96 clinical services including specialist clinics and less traditional settings such as general practice. Data were obtained on consecutive individuals who commenced DAAs from March 2016 to June 2019. Effectiveness was assessed by sustained virological response ≥12 weeks following treatment (SVR) using intention‐to‐treat (ITT) and per‐protocol (PP) analyses. Within REACH‐C, 10,843 individuals initiated DAAs (male 69%; ≥50 years 52%; cirrhosis 22%). SVR data were available in 85% (9,174 of 10,843). SVR was 81% (8,750 of 10,843) by ITT and 95% (8,750 of 9,174) by PP. High SVR (≥92%) was observed across all service types and participant characteristics. Male gender (adjusted odds ratio [aOR] 0.56, 95% confidence interval [CI] 0.43‐0.72), cirrhosis (aOR 0.52, 95% CI 0.41‐0.64), recent injecting drug use (IDU; aOR 0.64, 95% CI 0.46‐0.91) and previous DAA treatment (aOR 0.50, 95% CI 0.28‐0.90) decreased the likelihood of achieving SVR. Multiple factors modified the likelihood of loss to follow‐up including IDU ± opioid agonist therapy (OAT; IDU only: aOR 1.75, 95% CI 1.44‐2.11; IDU + OAT: aOR 1.39, 95% CI 1.11‐1.74; OAT only, aOR 1.36; 95% CI 1.13‐1.68) and age (aOR 0.97, 95% CI 0.97‐0.98). Conclusion: Treatment response was high in a diverse population and through a broad range of services following universal access to DAA therapy. Loss to follow‐up presents a real‐world challenge. Younger people who inject drugs were more likely to disengage from care, requiring innovative strategies to retain them in follow‐up.

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
A Semianalytical Approach for the Solution of Nonlinear Modified Camassa–Holm Equation with Fractional Order

This paper presents the approximate solution of the nonlinear acoustic wave propagation model is known as the modified Camassa–Holm (mCH) equation with the Caputo fractional derivative. We examine this study utilizing the Laplace transform (ℒ T ) coupled with the homotopy perturbation method (HPM) to construct the strategy of the Laplace transform homotopy perturbation method (ℒ T‐HPM). Since the Laplace transform is suitable only for a linear differential equation, therefore ℒ T‐HPM is the suitable approach to decompose the nonlinear problems. This scheme produces an iterative formula for finding the approximate solution of illustrated problems that leads to a convergent series without any small perturbation and restriction. Graphical results demonstrate that ℒ T‐HPM is simple, straightforward, and suitable for other nonlinear problems of fractional order in science and engineering.

Topic: Fractional Differential Equations Solutions
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences