jimnoneill/paper-to-field-training huggingface dataset:
Abstract 3983: Real-time imaging of human thyroid cancer progression in a fluorescent orthotopic nude mouse model

Abstract We report here a novel orthotopic mouse model of human thyroid cancer that can be imaged non-invasively with the use of red fluorescent protein (RFP). Human thyroid cancer cell lines NPA (papillary) and KAK-1 (anaplastic) were stably transfected to express RFP or the green fluorescent protein (GFP). The cells were then injected into the thyroid glands of 8-week old athymic mice. The animals were noninvasively imaged weekly, and sacrificed when premorbid. Their tumor was subsequently resected en bloc with the respiratory system for further processing and analysis. H&amp;E staining was performed to confirm the pathological diagnosis. Both anaplastic and papillary thyroid cancer cell lines led to the robust development of orthotopic fluorescent tumors in nude mice. While RFP-expressing tumors were easily identified transcutaneously, autofluorescence of the skin prevented visualization of GFP-expressing tumors, making GFP a suboptimal model. Injection of 5 × 10^5 cells was as efficacious in allowing tumor development as 5 × 10^6 cells. Tumors were first visualized for both cell lines via whole-body noninvasive imaging as early as four weeks post-implantation and could be monitored over time. The time to premorbid conditions varied greatly between mice and seemed to be associated with the tumor growth pattern rather than tumor size. The earliest appearance of morbidity was five weeks post-implantation in an animal with cachexia due to local compression of the esophagus by the tumor. Other mice died at later stages from metastatic disease. The bright fluorescence of the tumors allowed identification of multiple micrometastases at necropsy in the lungs, lymph nodes, and the vascular system, lesions that were not visible under white light. In summary, we have developed a novel orthotopic fluorescent mouse model of thyroid cancer that should serve a valuable role in the understanding of this disease and in the evaluation of new therapeutics, allowing assessment of the tumor response over time. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3983.

Topic: Cancer Research and Treatments
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Prevalence of Human T-Cell Lymphotropic Virus 1/2 Among Blood Donors in Owo, Ondo State, Nigeria: A Cross-Sectional Study

This study examines the sero-epidemiology of Human T-cell Lymphotropic Virus (HTLV) types 1 and 2 among blood donors in Owo, Ondo State, Nigeria, in the year 2024, focusing on prevalence, socio-demographic factors, and public health implications. Among 88 predominantly male donors (94.3%) aged 25–39 years (61.4%), the majority were Yoruba (86.4%) with secondary education (68.2%). Blood specimens were screened for HTLV using stringent kit from DIAPRO, Italy, with data analyzed via SPSS version 25. The study found a 3.4% HTLV-1/2 prevalence, higher than the West African regional average but lower than similar studies in Lagos. Socio-demographic factors, including age, gender, education, and occupation, showed no statistically significant correlation with infection. Similarly, HTLV prevalence was unaffected by blood group or donor type, although commercial donors dominated (71.6%), followed by relatives (23.9%) and voluntary donors (4.5%). Concerningly, only 3.4% of participants were aware of HTLV, with 87.5% mistakenly attributing transmission to mosquitoes and 86.4% associating its cause with supernatural factors. This highlights a critical need for targeted educational campaigns. The predominance of commercial donors raises further concerns about blood safety, as they are often linked to higher risks of transfusion-transmitted infections (TTIs). The findings emphasize the urgent need for routine HTLV screening in blood banks and strategies to increase voluntary, non-remunerated blood donation. Public education campaigns are essential to correct misconceptions and promote safer blood donation practices. This study underscores the importance of enhanced screening protocols, public education, and a shift towards voluntary blood donation to reduce transfusion risks and improve public health outcomes.

Topic: T-cell and Retrovirus Studies
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Relationship of Arousal Threshold to Sleep Stage Distribution and Subjective Estimates of Depth and Quality of Sleep

The relationship of arousal threshold, amounts of various sleep stages, and subjective rating of sleep was studied in two separate experiments involving 7 and 26 young adult subjects, respectively. Electroencephalographic sleep stage data, subjective response data, and arousal threshold data were collected over a series of nights in the sleep laboratory. Only nonsignificant relationships were found between magnitude of arousal threshold and amounts of various sleep stages or subjective rating of sleep quality in between-subjects analyses. However, when the nights representing extremes in arousal threshold were examined within-subject, it was found that nights of high threshold were accompanied by subjective reports of significantly better sleep in both studies and by a significant decrease in the amount of stage W in one study. Arousal threshold was not related to subjective depth of sleep in either study. Rather, subjective ratings of depth of sleep were significantly related to the amount of EEG-defined wakefulness and stage 1.

Topic: Sleep and Work-Related Fatigue
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Beneficial effects of delta sleep inducing peptide on metaphit seizures

The effects of delta sleep inducing peptide on metaphit (1-[1(3- isothiocyanatophenyl)-cyclohexyl] piperidine) provoked seizures in adult rats depending on whether it was administered prior or upon metaphit were studied. Animals were administered: 1. saline; 2. metaphit 3. DSIP and 30 min later metaphit (protected group); 4. metaphit and 8 h later DSIP (blocked group) or 5. DSIP alone. Upon the treatment, the rats were exposed to sound stimulation at hourly intervals and the incidence and behavioral severity (running, clonus and tonus) and EEG correlates of seizures were analyzed . Metaphit produced EEG abnormalities as spikes and spike-wave complexes and increased power spectra. Time-course studies revealed the peak of convulsive activity 7-12 h after metaphit administration. DSIP significantly increased power spectra of _ band no matter whether it was injected prior or after metaphit. Treatment with DSIP prolonged latency and reduced all convulsive components for a long period, as well as the mean seizure grade, but it was more pronounced in the protected than in the blocked group.

Topic: Sleep and Wakefulness Research
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Speaking and the world : a phenomenology of voice

The aim of this work is to describe how the human speaking voice can be simultaneously present and absent to those who hear and listen. A significant portion of the work is devoted to a study of Joseph Conrad's novel Heart of Darkness with a focus on the character Kurtz who is described as "little more than a voice". As well, I investigate Maurice Merleau-Ponty's idea of "authentic speech" and how that relates to a phenomenon I describe as "speech projecting a world". In the last section of the thesis I confront some realist presuppositions about how we understand the meaning of the term "the world" in order to show that realism is inadequate. The work concludes with a consideration of the ontological and metaphysical implications of saying that the human voice in speech is both present and absent.

Topic: Language, Metaphor, and Cognition
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Considerations and controversies of pharmacologic management of the pediatric kidney transplant recipient

Abstract Pediatric kidney transplantation has experienced considerable growth and improvement in patient and allograft outcomes over the past 20 years, in part due to advancements in immunosuppressive regimens and management. Despite this progress, care for this unique population can be challenging due to limited pediatric transplant data and trials, intricacies related to differences in children and adolescents compared with their adult counterparts, and limitations to long‐term survival facing all solid organ transplant populations. Immunosuppression and infection prevention practices vary from one pediatric transplant center to another and clinical controversies exist surrounding treatment and dosing. This review aims to summarize key aspects of pharmacologic management in this population and present pertinent data that describe the influence of practice to serve as a resource for practitioners caring for this unique specialty patient population. Additionally, this review highlights select controversies that exist within pediatric kidney transplantation.

Topic: Renal Transplantation Outcomes and Treatments
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
A Low-Noise 2.5GHz Direct-Conversion Receiver Frond-End with Low-Distortion Baseband Filters

A 2.5GHz direct conversion receiver front-end has a 3.2dB DSB NF, -14dBm IIP3, and +27dBm IIP2, referred to the LNA input. The RFI/Q mixers are configured as Gm-cells interfacing to current-mode CMOS I/Q continuous-time Elliptic filters. The filters can operate from a 1V supply and achieve an average input noise current of 11.2 pA/sqrt(Hz), <3% tuning accuracy and <0.5% I/Q bandwidth matching. The receiver draws 30mA from a 2.7V supply. The chip is fabricated in a 0.5& <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">#x003BC;</i> m 46GHz <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f<sub>T</sub><i/> BiCMOS process. The active area is 2.54 mm<sup>2</sup>.</i>

Topic: Radio Frequency Integrated Circuit Design
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
"Damned by faint praise": A Bayesian account

“Damned by Faint Praise” is the phenomenon whereby weak positive information leads to a negative change in belief. However, in a Bayesian model of belief revision positive information can seemingly only exert a positive change in belief. We introduce a version of Bayes’ Theorem incorporating the concept of epistemic closure. This reformalization is able to predict the conditions under which a ‘damned by faint praise’ effect is observed. Moreover, good, parameter-free fits are observed between the Bayesian model and the experimental data. This provides further support for the Bayesian approach to informal argumentation (e.g., Hahn &amp; Oaksford, 2007).

Topic: Experimental Behavioral Economics Studies
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
Dietz Delivers

As director of advertising and publicity for MGM, Howard Dietz had a long industrial knowledge after working with the company since 1924. Dietz informed the subcommittee that his team organizes film promotions and works with local representatives as well as the staff at the studio in California. Senator Tobey threw the same questions at Dietz about defining freedom of the press. “Freedom of speech within those definitions as relates to the press itself,” Dietz answered. Defining censorship of the press, Dietz argued it would take “a legal measure to restrain the press.” Tobey pressed Dietz on the possibility of legislation against censorship of the press, but Dietz noted that the Constitution already protected the freedoms of the press – no new laws should be necessary. Dietz also put to rest the controversy surrounding a theater in Nashville and possible interference from the studio. Schenck also resumed testimony.

Topic: Cinema and Media Studies
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
KAJIAN DISTRIBUSI SPASIAL DEBIT ALIRAN PERMUKAAN DI DAERAH ALIRAN SUNGAI (DAS) BERBASIS DATA SATELIT PENGINDERAAN JAUH

The aim of this paper is to analyze the spatial distribution of the water discharge in the Ciliwung watershed based on the remote sensing satellite data. Digital elevation model (DEM) is processed to determine the watershed border using the steepest slope method and also used to calculate pixels area. The calculated pixels area are used to determine the watershed and landcover areas in 3 dimension perspective, the landcover of the Ciliwung watershed is mapped by using SPOT-4 image acquired in 2007. All generated information are used as the input to determine the spatial distribution of the water discharge using the run-off coefficient table produced by related institutions. In the next step, the total water discharge in some outlets (Katulampa, Depok and Muara Ciliwung) are compared and the relationship between the landcover condition and the water discharge is evaluated. The result shows that DEM can be used to determine the watershed border and calculate the watershed area, which the results are almost same with the real condition. The spatial distribution of the water discharge is useful to analyse the water discharge contribution of each part of watershed to the total water discharge in the Ciliwung watershed. It shows that the water discharge in Katulampa outlet contributes 44 % of the total water discharge in the Ciliwung watershed. Further, some landcover types are identified in the high water discharge area. This kind of information is very useful for the regional planning and flood management activities.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Media Representations of China: A Comparison of<i>China Daily</i>and<i>Financial Times</i>in Reporting on the Belt and Road Initiative

Utilising critical discourse analysis with corpus-assisted methods of analysis, this study examines the representation of China by English-language newspapers in China versus media in the UK. The study focuses on the linguistic realisation of attitudinal meanings in news reports about the One Belt, One Road (OBOR) Initiative. A sample of news reports by China Daily and Financial Times, dated between March 2015 and March 2016, was collected. Assisted by the corpora and corpus software AntConc and ConcGram, the study first investigated themes from the headlines and key paragraphs in the corpora of China Daily and Financial Times and then compared the classification scheme of the lexis using the concordance lines of key concepts in the Belt and Road Initiative in the two corpora. It was found that China Daily, like other Chinese mainstream media, has attempted to emphasise the initiative's positive attributes and construct positive images of China as a peace-loving nation, an international cooperator, and an emerging global economic and responsible power. Images of China as represented in Financial Times are mixed and conflicting: on the one hand, China is portrayed as having a significant impact on the global economy; on the other hand, images of China as an authoritarian state, a militant and obstructive force, and a geopolitical threat prevail. The paper concludes with a recommendation that China continues to develop a locally grounded and globally minded media practice, in parallel with its renewed efforts to underline the power of Chinese culture in national development and international politics.

Topic: Media Studies and Communication
Subfield: Communication
Field: Social Sciences
Domain: Social Sciences
Effects of rapeseed-meal and fish-meal supplementation of maize silage-based diets upon voluntary intake, live-weight gain and wool growth of store lambs

Abstract Thirty-six individually penned lambs (mean live weight 32·4 (s.d. 2·27) kg) were offered maize silage ad libitum and one of three concentrate mixes, two of which contained extracted rapeseed meal (control and HR) and the other fish meal (FM). The concentrates were given according to live weight and in sufficient quantities to provide proportionately about 0·4 of the dry matter (DM) intake of the lambs. The dietary concentrations of nitrogen (N) g/kg DM were 22·4, 27·4 and 27·5 and of rumen undegradable N 6·6, 7·3 and 11·6 for the control, HR and FM diets respectively . Both the HR and FM diets depressed maize silage intakes compared with the control during the first 21 days ( P &lt; 0·05) and lambs given the FM diet continued to have lower intakes than control lambs ( P &lt; 0·05) throughout the experiment. The live-weight gain of HR lambs was considerably depressed in comparison with the control and FM lambs during the first 21 days of the experiment ( P &lt; 0·05). Overall HR lambs gained weight more slowly than control and FM lambs up to 45 kg live weight but the difference was not statistically significant. Food conversion ratio was better for FM than HR ( P &lt; 0·01). There were no treatment differences in wool growth. The results obtained provide little evidence that fish meal had any beneficial effects upon lamb growth compared with the control diet except a possible increase in the efficiency of metabolizable energy utilization.

Topic: Ruminant Nutrition and Digestive Physiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Synthesis and characterization of polyaniline coated gold nanocomposites

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Siti Nurzulaiha Mohd Zuber, Dzaraini Kamarun, Hamizah Zaki, Mohamad Shukri Kamarudin, Sabu Thomas, Nandakumar Kalarikkal; Synthesis and characterization of polyaniline coated gold nanocomposites. AIP Conference Proceedings 28 August 2015; 1674 (1): 020010. https://doi.org/10.1063/1.4928827 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search

Topic: Conducting polymers and applications
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Lengthened Simplex Codes With Complementary Correlation for Faulty Branch Detection in TDM-PON

This letter demonstrates a novel coding technique to accurately detect the faulty branch in time-division-multiplexing passive optical network (TDM-PON) infrastructure. The notion relies on encoding the probe signal with a novel composite structure coding technique to achieve the advantages of improved signal-to-noise ratio and resolution, reduced measurement time, and simplified complexity of branch identification. Proof-of-concept experiments on a constructed 1 × 32 TDM-PON with 20 km feeder fiber have been demonstrated, the experimental results are consistent with theoretical results and confirm the key advantages.

Topic: Optical Network Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Synthetic Models of Quasi-Stable Amyloid β40\nOligomers with Significant Neurotoxicity

The\nformation of soluble oligomers of amyloid β42 and 40\n(Aβ42, Aβ40) is the initial event in the pathogenesis\nof Alzheimer’s disease (AD). Based on previous systematic proline\nreplacement and solid-state NMR, we proposed a toxic dimer structure\nof Aβ42, a highly aggregative alloform, with a turn at positions\n22 and 23, and a hydrophobic core in the C-terminal region. However,\nin addition to Aβ42, Aβ40 dimers can also contribute to\nAD progression because of the more abundance of Aβ40 monomer\nin biological fluids. Here, we describe the synthesis and characterization\nof three dimer models of the toxic-conformation constrained E22P-Aβ40\nusing l,l-2,6-diaminopimeric acid (DAP) or l,l-2,8-diaminoazelaic acid (DAZ) linker at position 30,\nwhich is incorporated into the intermolecular parallel β-sheet\nregion, and DAP at position 38 in the C-terminal hydrophobic core.\nE22P-A30DAP-Aβ40 dimer (&lt;b&gt;1&lt;/b&gt;) and E22P-A30DAZ-Aβ40\ndimer (&lt;b&gt;2&lt;/b&gt;) existed mainly in oligomeric states even after\n2 weeks incubation without forming fibrils, unlike the corresponding\nmonomer. Their neurotoxicity toward SH-SY5Y neuroblastoma cells was\nvery weak. In contrast, E22P-G38DAP-Aβ40 dimer (&lt;b&gt;3&lt;/b&gt;) formed β-sheet-rich oligomeric aggregates, and exhibited\nmore potent neurotoxicity than the corresponding monomer. Ion mobility–mass\nspectrometry suggested that high molecular-weight oligomers (12–24-mer)\nof &lt;b&gt;3&lt;/b&gt; form, but not for &lt;b&gt;1&lt;/b&gt; and &lt;b&gt;2&lt;/b&gt; after 4 h incubation. These findings indicate that formation of\nthe hydrophobic core at the C-terminus, rather than intermolecular\nparallel β-sheet, triggers the formation of toxic Aβ oligomers.\nCompound &lt;b&gt;3&lt;/b&gt; may be a suitable model for studying the etiology\nof Alzheimer’s disease.

Topic: Alzheimer's disease research and treatments
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
The Lomé Convention and Industrial Cooperation: A New Relationship Between the European Community and the ACP States?

The Lome agreement includes provisions for moving beyond traditional trade and aid policies to include more active forms of industrial, technical, and financial cooperation and a commodity price-support system. Thus, the Kingston Memorandum called for the establishment of specific targets and objectives to be obtained in the promotion of particular industries for the duration of the Convention. As the operation of the European Community Generalized System of Preferences scheme has illustrated, general policies are empty concessions to those states that are too weak to compete in an international economic system dominated by the main industrial states. Although the Convention was signed in February 1975 and the African Caribbean Pacific Countries states have attached great importance to Title III, for many reasons the delineation of the organization, responsibilities, and size of the Committee and the Centre has been slow. Industrial cooperation as defined in Title III is dependent on the availability of instruments for granting technical and financial assistance.

Topic: International Law and Aviation
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences