jimnoneill/paper-to-field-training huggingface dataset:
Association of <i>KRAS</i> G13D Tumor Mutations With Outcome in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy With or Without Cetuximab

Purpose We investigated in the first-line setting our previous finding that patients with chemorefractory KRAS G13D–mutated metastatic colorectal cancer (mCRC) benefit from cetuximab treatment. Methods Associations between tumor KRAS mutation status (wild-type, G13D, G12V, or other mutations) and progression-free survival (PFS), survival, and response were investigated in pooled data from 1,378 evaluable patients from the CRYSTAL and OPUS studies. Multivariate analysis correcting for differences in baseline prognostic factors was performed. Results Of 533 patients (39%) with KRAS-mutant tumors, 83 (16%) had G13D, 125 (23%) had G12V, and 325 (61%) had other mutations. Significant variations in treatment effects were found for tumor response (P = .005) and PFS (P = .046) in patients with G13D-mutant tumors versus all other mutations (including G12V). Within KRAS mutation subgroups, cetuximab plus chemotherapy versus chemotherapy alone significantly improved PFS (median, 7.4 v 6.0 months; hazard ratio [HR], 0.47; P = .039) and tumor response (40.5% v 22.0%; odds ratio, 3.38; P = .042) but not survival (median, 15.4 v 14.7 months; HR, 0.89; P = .68) in patients with G13D-mutant tumors. Patients with G12V and other mutations did not benefit from this treatment combination. Patients with KRAS G13D–mutated tumors receiving chemotherapy alone experienced worse outcomes (response, 22.0% v 43.2%; odds ratio, 0.40; P = .032) than those with other mutations. Effects were similar in the separate CRYSTAL and OPUS studies. Conclusion The addition of cetuximab to first-line chemotherapy seems to benefit patients with KRAS G13D–mutant tumors. Relative treatment effects were similar to those in patients with KRAS wild-type tumors but with lower absolute values.

Topic: Colorectal Cancer Treatments and Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Gene selection and classification by entropy-based recursive feature elimination

We analyse E-RFE (entropy-based recursive feature elimination), a new wrapper algorithm for fast feature ranking in classification problems. The E-RFE method operates the elimination of chunks of uninteresting features according to the entropy of the weights distribution of a SVM classifier. The method is designed to support computationally intensive model selection in classification problems in which the number of features is much larger than the number of samples. We test the elimination procedure on synthetic data sets, and we demonstrate the applicability of E-RFE for the identification of biomedically important genes in predictive classification of microarray data.

Topic: Gene expression and cancer classification
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Nonsurgical Cure of Endocarditis Associated With a Pacemaker

Endocarditis associated with the use of a transvenous pacemaker electrode remains an infrequent occurrence in spite of the increasing numbers of such pacemakers being utilized. However, when it does occur, endocarditis in such a setting poses a serious therapeutic dilemma. Eradication of infection is extremely difficult without removal of the foreign body, but since transvenous pacemakers usually become fixed to the endocardial surface with passage of time, their removal may require major intracardiac surgery. This report illustrates endocarditis in a patient with two transvenous pacemaker electrodes, in whom an apparent cure has been obtained with the use of combined antibiotic therapy without removal of either electrode. <h3>PATIENT SUMMARY</h3> A 59-year-old man was admitted to the Albuquerque Veterans Administration Hospital in November 1973, with complaints of shaking chills and temperature elevation of eight weeks' duration. These febrile episodes occurred sporadically and infrequently until two weeks prior to admission, at which

Topic: Cardiac pacing and defibrillation studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Changes in physicochemical property and its potential regulatory mechanism for the formation of water core of the Fuji apples post‐harvesting

Summary This study analysed the factors for influencing the occurrence of water core in apples and proposed a potential metabolism following its post‐harvesting. By comparing the ordinary pulp and the region within the water core in different post‐harvesting stages of the Fuji apples, although the occurrence of water core did not significantly change the appearance of the apples, its interior firmness decreased with increased cell permeability. Furthermore, fructose content decreased, and sorbitol content increased rapidly accompanied by a reduction of sorbitol dehydrogenase activity at the site of water core. The cell morphology also demonstrated that the cells became denser and the blue aggregates formed. It indicated that the cell walls were saturated with locally highly accumulated sorbitol, followed by visualised transparent spots. In summary, the occurrence of water core during the post‐harvesting of Fuji apples was found to be related to the increased sorbitol content and the corresponding decreased dehydrogenase activity.

Topic: Postharvest Quality and Shelf Life Management
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Antifungal activity of the extracts and fractions of dahlia tuber (Dahlia variabilis) against pathogenic skin fungi

Saryono, Octarina N, Yuharmen, Pratiwi NW, Ardhi A. 2017. Antifungal activity of the extracts and fractions of dahlia tuber (Dahlia variabilis) against pathogenic skin fungi. Nusantara Bioscience 9: 146-151. Dahlia plant (Dahlia variabilis) can be easily found in the highlands in Indonesia and its tuber has been reported to have some bioactive compounds which are potential to be utilized as an antimicrobial agent. This study aimed to determine antifungal activity and minimum inhibitory concentration (MIC) of n-hexane and methanol extracts and fractions of red-flowered dahlia tubers against pathogenic skin fungi Candida albicans and Microsporum gypseum using disc diffusion method. The n-hexane and methanol extracts and fractions of dahlia tuber showed their antifungal activity against C. albicans and M. gypseum, with the larger activity, was found in both extracts and fractions of methanol. The best fractions of n-hexane and methanol were chosen and determined their minimum inhibitory concentration; which the F5 n-hexane fraction and the F2 methanol fraction gave the MIC of 1.50% and 0.50% against C. albicans respectively, whereas both F1 n-hexane and F2 methanol fraction gave the MIC of 0.50% against M. gypseum. The high antifungal activity of F2 of methanol extract against C. albicans and M. gypseum allowed this fraction to be utilized as a medicinal drug for candidiasis and other fungal skin infections.

Topic: Phytochemistry and Biological Activities
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Agonistic Democracy and the Question of Education

In many policies for and practices of education for democratic citizenship it is assumed that the democratic community is a community of shared democratic values. On such an account, education has the task of including “newcomers” into this community by ensuring that they adopt and internalize the common democratic values. In this chapter, I discuss the work of two authors, Chantal Mouffe and Jacques Rancière, who both have challenged this understanding of democracy and the democratic community. Both authors highlight the contested (Mouffe) and sporadic (Rancière) nature of the democratic community, thus bringing into view the work done to constitute the political community. They also highlight that this constitution does not happen before democratic politics can take place, but actually is an essential part of it. I provide a reconstruction of Mouffe’s and Rancière’s ideas and explore the implications for education.

Topic: Critical Theory and Political Philosophy
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
The Contribution of Modernized Fishing Technology on the Socio-economic Status of the Takalar People of South Sulawesi in Indonesia

This research examined the influence of modernized technology on the Takalar fishing community of South Sulawesi in Indonesia. The researcher focused on the socio-economic changes resulting from the use of improved technology in the area. A qualitative approach was employed to establish the changes that have occurred due to the use of technology. Both primary and secondary data were used. Data analysis was carried out using a qualitative-descriptive method. The findings revealed a tremendous improvement in the socio-economic status after the fishing communities adopted modernized technology, with such changes being evident among the capital owners (punggawa) and the employees (sawi). In was further established that the economic changes include increased family incomes, improved housing conditions, ownership of fully furnished homes, and accessibility to easy means of transport means. While, social changes include the changes in labor relations, from mutual cooperation to a wage based system, change in social mobility: symbolized by ownership of houses and transport facility, ownership of fishing boats and equipment, and the shift from employee status to ownership status, changes in family structures from nuclear family to extended family system, and also a significant increase in the education levels of most families in the region.

Topic: Marine and Coastal Ecosystems
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Educators as decolonial intellectuals: revolutionary thought from Gramsci to Fanon

For several decades, the Gramscian notion of the intellectual has been a popular framework to view the potentiality of educators as counter-hegemonic cultural workers. While this was an invaluable contribution to the field of critical education, notions of the intellectual have largely focused on class conflict. For a deeper theorization of the intellectual and race, we turn to the work of decolonial thinker Frantz Fanon. In his work, Fanon theorizes the role of the intellectual amid the struggle against colonialism. In this article, we examine Fanon's intellectual work as well as his writing on the 'colonized intellectual' to articulate what we describe as a Fanonian decolonial intellectual. We conclude by highlighting the importance of Fanon's contributions on the intellectual for educators of color, who presently find themselves compromised by a hegemony characterized by neoliberal multiculturalism in education.

Topic: Political theory and Gramsci
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Resistance to chloroquine of Plasmodium falciparum from Burma

Journal Article Resistance to chloroquine of Plasmodium falciparum from Burma Get access David F. Clyde, David F. Clyde University of Maryland, Baltimore, Maryland, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nyunt Hlaing, Nyunt Hlaing Malaria Institute, Aung San Myo, Burma Search for other works by this author on: Oxford Academic PubMed Google Scholar Franco Tin Franco Tin Malaria Institute, Aung San Myo, Burma Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 66, Issue 2, 1972, Pages 369–370, https://doi.org/10.1016/0035-9203(72)90258-1 Published: 01 January 1972

Topic: Malaria Research and Control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Managed Care as a Transference Object

Abstract Managed care demands in psychotherapy are too easily treated in a surface fashion and without regard for their potential of holding unconscious derivative importance and meaning. There is internal and external pressure on the therapist to abandon psychody-namic psychotherapeutic skills in managed care psychotherapy. When the managed care benefit becomes the primary focus of clinical attention, it supersedes the client'S needs, and negative transference and resistance are externalized and not handled clinically. This paper illustrates the contribution psychodynamic understanding and method can make to managed care psychotherapies by demonstrating the clinical phenomenon and handling of the client'S and therapist'S transferences to managed care and client'S defensive use of managed care recommendations.

Topic: Psychotherapy Techniques and Applications
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
2006), Direction observation of the F region dynamo currents and the spatial structure of the EEJ by CHAMP, Geophys

[1] The satellite CHAMP in its low-altitude polar orbit, and with its high-resolution magnetic field measurements, provides the opportunity to investigate ionospheric currents in great detail. In this study we focus on average features of equatorial current systems during day time. Considering quiet time observations from the period Aug. 2000 to Oct. 2004 we determined the mean spatial structure of the EEJ current. The existence of reverse currents at the flanks of the primary eastward current is confirmed. More importantly, average characteristics of the F region dynamo driven currents are observed for the first time throughout the daytime. The meridional current system, driven by westward thermospheric winds, peaks around noon. Similar meridional currents, but flowing in the opposite sense, are observed at the dusk sector. At CHAMP altitudes we find over the dip equator in the F region a vertical sheet current of about 6 mA/m oriented downward at noon and an upward current of 4 mA/m around sunset.

Topic: Ionosphere and magnetosphere dynamics
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Industrial Entrepreneurship in Madras State.

Journal Article Industrial Entrepreneurship in Madras State Get access Industrial Entrepreneurship in Madras State.. By J. J. Berna. (Bombay and London: Asia Publishing House for the International Industrial Development Center, Stanford Research Institute, 1960. Pp. xvi + 239. 45s.) Gautam Mathur Gautam Mathur Magdalene College, Cambridge Search for other works by this author on: Oxford Academic Google Scholar The Economic Journal, Volume 71, Issue 282, 1 June 1961, Pages 415–416, https://doi.org/10.2307/2228784 Published: 01 June 1961

Topic: Indian Economic and Social Development
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Apparent temperature as a modifier of the effects of air pollution on respiratory disease hospital admissions in Secunda, South Africa

TPS 681: Short-term health effects of air pollutants 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background: Due to climate change, an increase of 34°C in ambient temperature is projected along the South African coast and 6-7°C inland during the next 80 years. Very few studies in Africa investigated effect modification by a temperature indicator (e.g. apparent temperature, Tapp) on the human health effects of air pollution. Methods: Respiratory disease (RD) admission data (ICD10 J00-J99) were obtained from MediClinic for the two hospitals located in Secunda; after ethics approval. The study period is 1 January 2011 to 31 October 2016. NO2, SO2, PM10, PM2.5, temperature and relative humidity data were obtained from the South African Weather Services. A case-crossover epidemiological study design was applied. The present study focused on lag0-1; as most other studies. Models were adjusted for public holidays and Tapp. Days with Tapp below and above/equal the median (14.9C) were classified as cold and warm days, respectively. Results: Of the 14 568 RD admissions, approximately equal number of females and males were admitted. 47%, 45% and 8% of the admissions were from 0-14, 15-64 and >=65 year olds, respectively. The daily NO2, SO2, PM2.5 and PM10 levels were 12.4, 8.5, 32.3 and 68.6 μm/m3, respectively. Daily air pollutant levels regularly exceeded the WHO guidelines. On cold days there were no significant associations between the air pollutants and RD admissions, but there were strong associations on warm days, except for NO2. On warm days, 0-14 year olds and females were more susceptible to PM2.5, PM10 and SO2, e.g. RR 1.12 95%CI 1.02-1.23 for 14 year olds and PM2.5 compared to the unstratified analyses RR 1.01 95%CI 1.00-1.02. Conclusions: These results indicate that the risk of RD hospital admission due to ambient air pollution exposure is different on cold and warm days in Secunda.

Topic: Air Quality and Health Impacts
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Painful memories: Chronic pain as a form of re-membering

Advances in scientific research enable chronic pain to be understood as a form of body memory. Inquiring into chronic pain can expand our understanding of the processes of memory and, in particular, can illuminate configurations of modern and postmodern memory as they are constructed and mediated through mundane, concrete and corporeal experiences.

Topic: Pain Management and Treatment
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Prototype wireless network for internet of things based on DECT standard

This paper presents a software prototype of a wireless network for the Internet of Things (IoT) based on the DECT (Digital Enhanced Cordless Telecommunication) standard. It proposes an architecture for encapsulating commands from the most common IoT protocol, MQTT (Message Queuing Telemetry Transport), into SIP (Session Initiation Protocol) packets. A module is created to embed MQTT-SN (MQTT for Sensor Networks) packets into SIP packets. The module is developed in Go language using the built-in "net" library. Delivery of MQTT-SN packets to IoT devices is carried out using the SIP protocol. Source codes and instructions for installing the gateway can be found at https://github.com/iSinyavsky/mqtt-sn-sip-gateway.

Topic: IoT Networks and Protocols
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Paradox of Professionalism

This book is about the role of lawyers in constructing a just society. Its central objective is to provide a deeper understanding of the relationship between lawyers' commercial aims and public aspirations. Drawing on interdisciplinary and comparative perspectives, it explores whether lawyers can transcend self-interest to meaningfully contribute to systems of political accountability, ethical advocacy and distributional fairness. Its contributors, some of the world's leading scholars of the legal profession, offer evidence that although justice is possible, it is never complete. Ultimately, how much - and what type of - justice prevails depends on how lawyers respond to, and reshape, the political and economic conditions in which they practise. As the essays demonstrate, the possibility of justice is diminished as lawyers pursue self-regulation in the service of power; it is enhanced when lawyers mobilize - in the political arena, workplace and law school - to contest it.

Topic: Legal Education and Practice Innovations
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Latin and vernacular from Dante to the age of Lorenzo (1321–<i>c</i>. 1500)

The previous chapter stressed the ways in which Dante's achievement represented a challenge to prevailing orthodoxies: he had chosen the vernacular for a major poetic work, and the Commedia itself had engendered a tradition of commentary on a par with that usually reserved for classical texts. Petrarch's literary hegemony, which from 1350 onwards restored Latin to its privileged position, in a sense constituted a linguistic counterrevolution. The rivalry between the two languages was to continue for two centuries from the death of Dante, and since it represents an obligatory topic in critical thinking in this period it seems best to treat the question in this separate chapter. There are four major stages in the debate: first the Petrarchan revolution; second the arguments for and against the vernacular around 1400; third the crucial decade 1430–40; and finally the age of Landino, Poliziano and Lorenzo de’ Medici.

Topic: Renaissance and Early Modern Studies
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
CASE REPORT Open Access Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation

Background: Appendiceal adenocarcinoma is rare with a frequency of 0.08 % of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented. Case Presentation: A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis. Although ultrasonography and voided urinary cytology were negative, abdomen computed tomography (CT) scan and cystoscopy and subsequent pathological examination revealed a mass exclusively located in the anterior wall of the bladder. Histopathology of the transurethral bladder resection revealed a bladder adenocarcinoma [6 cm (at the maximum diameter) × 2,5 cm; approximate weight: 10 gr] with focal mucinous aspects penetrating the muscle and perivisceral fat. Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm × 3 cm × 2 cm) extending to the loco-regional lymph nodes. Appendectomy and right hemicolectomy, linfoadenectomy and partial cystectomy were performed. The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes. Conclusions: The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder. Background The appendiceal adenocarcinoma invading the urinary bladder is extremely rare [1-4], and it is very difficult to be diagnosed before the surgical inspection. Here we describes a case of appendiceal cystoadenocarcinoma metastising the bladder anterior wall diagnosed in a patient with monosymptomatic episodes of gross hematuria. Our diagnostic schema and the adopted pharmacological treatment are also discussed.

Topic: Intraperitoneal and Appendiceal Malignancies
Subfield: Surgery
Field: Medicine
Domain: Health Sciences