jimnoneill/paper-to-field-training huggingface dataset:
Interesting | Intercultural | Innovative | Inquiry How real contexts lead to real learning

Macquarie Primary School has a long-held reputation as a community school, where students, parents and carers, and the broader community, work together with a dedicated professional team to ensure every child achieves success. With families from around the world, our school is proudly multicultural. Creativity and curiosity are nurtured at Macquarie and inquiry is the basis of our learning philosophy. One of the school's strategic priorities is to improve teacher pedagogy around inquiry based learning. A key marker of success in this area has been the continued framing, development and embedding of the Macquarie Curriculum Map, with alignment to the Australian Curriculum.

Topic: Education Systems and Policy
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Targeting retinoid receptors with dysregulated microNRAs in pancreatic duct adenocarcinoma

Retinoid (i.e., vitamin A, all-trans retinoic acid and other synthetic derivatives of vitamin A) induce cell differentiation and growth via the interaction of retinoid receptors in various normal and malignant cells. In addition to the success of all-trans-retinoic acid -based differentiation therapy in acute promyelocytic leukemia, emerging attempt in the combination of RA therapy and traditional chemotherapy has been studied in various solid cancer. Retinoid receptors (RARA, RARB, RXRA, and RXRB) and retinoic acid were reported to be down-regulated in pancreatic duct adenocarcinoma (PDAC) compared to normal pancreas. Moreover, the reduced expression of retinoid receptors correlates with the expression of these markers involved in the cell differentiation and the epithelial-mesenchymal transition. Further analysis revealed that the expressions of RARA and RXRB are associated with the overall survival in PDAC patients. Reduced level of retinoid and their receptors is associated with worse survival outcomes in PDAC patients. Yet, the mechanism of the down-regulation of retinoid receptors is not well defined. miRNA, as a class of small non-coding RNAs, can incorporate into the RNA-induced silencing complex and post-transcriptionally regulate the mRNA expression typically by binding to the 3’ untranslated region (3’-UTR) of the complementary mRNA sequence. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors. For this purpose, we first performed a bioinformatics research to reveal conserved target sequences for deregulated miRNAs within the 3’UTR region of retinoid receptor mRNA. Next, we investigated the expression of selected retinoid receptors and miRNAs in BxPC-3, DanG, MiaPaCa-2, Panc-1 cell lines and the Human Pancreatic Duct Epithelial (HPDE) cell line. Further, we investigated the expression level by manipulating the expression of selected miRNAs. We demonstrated that none of these miRNAs can target the selected retinoid receptors in vitro. Therefore, we conclude that dysregulated miR-138, miR-206, miR-613, miR-9 and miR-27a/b are not involved in the regulation of the expression of retinoid receptors in PDAC patients.

Topic: Retinoids in leukemia and cellular processes
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
EFFECTS OF ENZYMATIC HYDROLYSIS ON CRUDE PALM OLEIN BY LIPASE FROM <i>CANDIDA RUGOSA</i>

ABSTRACT The effects of enzymatic hydrolysis on crude palm olein (CPOlein) by lipase from Candida rugosa were investigated. Reaction variables, namely water content, reaction temperature and enzyme concentration on hydrolysis of CPOlein were examined. Comparison was also made between CPOlein and hydrolyzed crude palm olein (HCPOlein) for melting point, percentage of free fatty acids (FFA) and viscosity. The optimum conditions for the production of hydrolyzed oil or FFA‐rich oil in enzymatic hydrolysis of CPOlein were reaction temperature of 50C, 1% (w/w) lipase from C. rugosa and 50% (w/w) water content. FFA in CPOlein increased to 97.9% after the hydrolysis process, which showed an increase of 61 folds. The differences in viscosity between the CPOlein and HCPOlein at different temperatures were statistically significant ( P &lt; 0.05). The slip melting point of CPOlein was 17C. After hydrolysis, the melting point for CPOlein increased by 160%, reaching 44.4C.

Topic: Enzyme Catalysis and Immobilization
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Recruitment in higher education institution: the mediating role of parents' expectations and encouragement

Copyright © 2016 Inderscience Enterprises Ltd.Previous research has demonstrated the direct relationship between parents' education, parents' expectation and encouragement and college choice decision; however, study on the possibility of variables having a mediating role on college choice decision has yet to be investigated. This paper attempts to address this knowledge gap and seeks to serve a provocative role in explaining students' college choice decision. The study was conducted among prospective students. The results revealed the direct and indirect relationship between parents' education and college choice decision. The results support all of the hypothesised relationships, suggesting the importance of the role of parents' expectation and encouragement in the students' decision to enrol in higher education institution. This significant finding implies that the challenges of higher learning institutions should also focus on strategies to engage with parents so that students will decide to enrol in the marketed higher learning institution. Theoretical and managerial implications were also discussed.

Topic: Higher Education Research Studies
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
CHINA BETS ON HOMEGROWN DRUGS

RETURN TO ISSUEPREVNewsNEXTCHINA BETS ON HOMEGROWN DRUGSNEW GOVERNMENT FUND will give $1 billion to promising Chinese drug labsJEAN-FRANÇOIS TREMBLAYView Author Information C&EN HONG KONGCite this: Chem. Eng. News 2008, 86, 48, 28–29Publication Date (Print):December 1, 2008Publication History Published online14 November 2010Published inissue 1 December 2008https://pubs.acs.org/doi/10.1021/cen-v086n048.p028https://doi.org/10.1021/cen-v086n048.p028newsACS PublicationsCopyright © 2008 AMERICAN CHEMICAL SOCIETYArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Drug discovery,Pharmaceuticals Get e-Alerts

Topic: Pharmaceutical Economics and Policy
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Development of a Small Two Axis Spherical Motor Type Laser Tracker with Submicron Measurement Accuracy

Recently, it is in great need for measurement of the three dimensional surface form of the car and the aircraft, the path of the industrial robot and the machine tool, and so on with a high degree of accuracy. We have proposed a novel laser tracking three dimensional position measurement system which can measure the 3D position with submicron accuracy at more than 1[m] by combining the oscillating lever mechanism with the spherical motor. Before making the full system, we made the first and the second prototype spherical motor type laser tracker unit and tested them. The average measurement error of the developed laser tracker 2 is 0.45[μm] and the standard deviation is 0.54[μm], which satisfy the specifications needed for the full system.

Topic: Engineering Applied Research
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
Childrenʼs Self-reported Physical Fitness In Relation To Parent Report And Objective Measure

It is unknown if children can accurately self report their overall level of physical fitness and rate of perceived exertion following a maximal exercise test. PURPOSE To determine the relationship between self reported and parent reported physical fitness in a pediatric population. METHODS Seventy-five children were referred to a pediatric exercise lab for cardiopulmonary exercise testing (64 tested on cycle ergometer using ramp protocol, 11 tested on treadmill using Bruce protocol). After test procedures were explained, each child was asked to rate their physical ability on a scale of 1 to 100 (1=highest ability, 100=lowest ability). The parent/guardian of each child was also asked to rate the child's fitness on the same scale. The child was asked to predict how hard the exercise test would be on a scale of 6–20 (Borg scale for children). Each child was asked again to rate their maximal exertion using the Borg scale at the end of the test. RESULTS There were 42 boys, age 11.7±3.4 years and 33 girls, age 13.9±3.6 years. Forty had structural heart disease (HD). The correlation between parent and child reporting of physical fitness was moderate (r=0.57, p < 0.01). Both child and parent reports correlated poorly with VO2max. However, the average of parent and child reports had slightly stronger correlation with VO2max (r=0.37, p=0.01). Compared with girls, boys were more likely to report better than their parent (p=0.07). Children ≤12 years were more likely to report better than their parent (p < 0.01) than children > 12. The parent-child correlation on physical fitness was similar between children with HD and children without HD. Predicted maximal rate of perceived exertion increased from a mean of 13.5 at pre test to a mean of 15.8 at post test (p < 0.001). CONCLUSION There was moderate correlation between parent or child report of physical fitness, but neither predicts the child's objectively measured fitness level. Young age and male patients tend to self report a better fitness level than the parent. In children, the perceived exertion is generally higher than anticipated exertion in clinical exercise testing.

Topic: Children's Physical and Motor Development
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis

Abstract Aztreonam is a monocyclic β‐lactam antibiotic often used to treat infections caused by Enterobacteriaceae or Pseudomonas aeruginosa . Despite the long history of clinical use, population pharmacokinetic modeling of aztreonam in renally impaired patients is not yet available. The aims of this study were to assess the impact of renal impairment on aztreonam exposure and to evaluate dosing regimens for patients with renal impairment. A population model describing aztreonam pharmacokinetics following intravenous administration was developed using plasma concentrations from 42 healthy volunteers and renally impaired patients from 2 clinical studies. The final pharmacokinetic model was used to predict aztreonam plasma concentrations and evaluate the probability of pharmacodynamic target attainment (PTA) in patients with different levels of renal function. A 2‐compartment model with first‐order elimination adequately described aztreonam pharmacokinetics. The population mean estimates of aztreonam clearance, intercompartmental clearance, volume of distribution of the central compartment, and volume of distribution of the peripheral compartment were 4.93 L/h, 9.26 L/h, 7.43 L, and 6.44 L, respectively. Creatinine clearance and body weight were the most significant variables to explain patient variability in aztreonam clearance and volume of distribution, respectively. Simulations using the final pharmacokinetic model resulted in a clinical susceptibility break point of 4 and 8 mg/L, respectively, based on the clinical use of 1‐ and 2‐g loading doses with the same or reduced maintenance dose every 8 hours for various renal deficiency patients. The population pharmacokinetic modeling and PTA estimation support adequate PTAs (&gt;90% PTA) from the aztreonam label for dose adjustment of aztreonam in patients with moderate and severe renal impairment.

Topic: Antibiotics Pharmacokinetics and Efficacy
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Effect of Quinidine on Digoxin Concentration in Skeletal Muscle and Serum in Patients with Atrial Fibrillation

Medical Intelligence from The New England Journal of Medicine — Effect of Quinidine on Digoxin Concentration in Skeletal Muscle and Serum in Patients with Atrial Fibrillation — Evidence for Reduced Binding of Digoxin in Muscle

Topic: Cardiac electrophysiology and arrhythmias
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
ChemInform Abstract: Synthesis of Sulfur Analogues of Isocannabinoids and Tetrahydrocannabinols.

Abstract The phenols (I) are transformed to the thio compounds (V) or (IX) via the Newman‐Kwart reaction.

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
CCDC 291437: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Design of 4 Elements Broadband Circularly Polarized Microstrip Array Antenna at C-Band

Sequentially rotated technique was applied to the design of 4 elements broadband circularly polarized microstrip array antenna with dual-feed square patch elements at C-Band.Wilkinson power divider which can improve the impedance bandwidth was used to construct the feed network.Sequentially rotated technique and Wilkinson power divider lead to the improvement in the axial ratio bandwidth.Back-fed structure eliminates the impact of the feeding network radiation on the circularly polarized characteristics of the antenna,and further improves the axial ratio bandwidth of the array.The measured results of the array show that the impedance bandwidth of the array is 75.0% and 2 dB axial ratio bandwidth is 45.6%.

Topic: Antenna Design and Analysis
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Time-Varying Liquidity and Momentum Profits

A basic intuition is that arbitrage is easier when markets are most liquid. Surprisingly, we find that momentum profits are markedly larger in liquid market states. This finding is not explained by variation in liquidity risk, time-varying exposure to risk factors, or changes in macroeconomic condition, cross-sectional return dispersion, and investor sentiment. The predictive performance of aggregate market illiquidity for momentum profits uniformly exceeds that of market return and market volatility states. While momentum strategies have been unconditionally unprofitable in the United States, in Japan, and in the Eurozone countries in the last decade, they are substantial following liquid market states.

Topic: Financial Markets and Investment Strategies
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Coarse-Fine Convolutional Deep-Learning Strategy for Human Activity Recognition

In the last decade, deep learning techniques have further improved human activity recognition (HAR) performance on several benchmark datasets. This paper presents a novel framework to classify and analyze human activities. A new convolutional neural network (CNN) strategy is applied to a single user movement recognition using a smartphone. Three parallel CNNs are used for local feature extraction, and latter they are fused in the classification task stage. The whole CNN scheme is based on a feature fusion of a fine-CNN, a medium-CNN, and a coarse-CNN. A tri-axial accelerometer and a tri-axial gyroscope sensor embedded in a smartphone are used to record the acceleration and angle signals. Six human activities successfully classified are walking, walking-upstairs, walking-downstairs, sitting, standing and laying. Performance evaluation is presented for the proposed CNN.

Topic: Context-Aware Activity Recognition Systems
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Asbestos replacement fibre

Asbestos has been banned in many countries but many countries, including developing countries, are still using asbestos or materials containing asbestos. Substitute materials have been studied and developed over a long period of time because of the hazards of asbestos, and many people have recently shown interest in the hazards of substitute materials. However, comprehensive information about the types of asbestos substitutes, their use and health hazards, and references for the protection for the health of workers is limited. The purpose of this study is to provide people in the related industries with information on the types and health hazards of fibrous materials that can be used as asbestos substitutes. According to the patent resources from the United States and Europe, fibrous materials have been used to develop asbestos-free products since before 1980. Recently, the health hazards of asbestos substitutes have been assessed and many additional researches are required. However, only some of the substitute materials have been assessed for health hazards, and health hazard data has not been sufficient in many cases. Therefore, efforts should be made to minimize workers’ exposure to substitute materials that do not contain asbestos.

Topic: Occupational and environmental lung diseases
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Total Synthesis of the\nRepeating Unit of Streptococcus pneumoniae Zwitterionic Polysaccharide\nSp1

Reported herein is the total synthesis\nof the trisaccharide repeating\nunit of Streptococcus pneumoniae zwitterionic\npolysaccharide Sp1 containing a rare sugar, 2-acetamido-4-amino-2,4,6-trideoxy-d-galactose (AAT), and three consecutive 1,2-&lt;i&gt;cis&lt;/i&gt;-glycosidic linkages. The total synthesis was completed via highly\nstereoselective glycosylations and late-stage oxidation as key steps\ninvolving a longest linear sequence of 21 steps with 4.4% overall\nyield.

Topic: Carbohydrate Chemistry and Synthesis
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Influence of hydrogen bonding and structural features of coal on its liquefaction

To describe coal liquefaction chemistry quantitatively, the chemical structural characteristics of a given coal were defined on the molecular level, and the reactivity of the coal was examined under hydroliquefaction conditions using two solvents, tetrahydroquinoline (THQ) and a mixture of tetralin and pyrene. A Wyoming subbituminous coal from the Rawhide Mine was found to consist of different aromatic clusters linked to each other in a specific way. At least four single-aromatic-ring clusters are linked to each other by alkyl C-C bonds, making a group of single aromatic ring clusters. These groups are connected to each other by ester groups. At least two clusters of two-fused-aromatic-ring structures are joined by alkyl C-C bonds, making a group of two-fused-ring clusters. These groups are connected to each other by ester groups and probably by ether groups. Three- or more-fused-aromatic-ring clusters are connected to each other in a similar manner. The structural data of the coal were related to product distribution and hydrogen consumption in its hydroliquefaction. The reaction of this coal with THQ at 300/sup 0/C revealed that the hydrogen-donor solvent provided little hydrogen to the coal product, but the solvent molecules themselves reacted and combined with the coal to form inseparable coal-THQ more » complexes or compounds. The reactions with a mixture of tetralin and pyrene under H/sub 2/ pressure showed that strong linkages between aromatic clusters of the coal were cleaved extensively at 400/sup 0/C but the liberated clusters recombined to become a nondistillable product. At 454/sup 0/C, in addition to the cleavage of the linkages, dealkylation was a dominant process as indicated by a 2.8-fold increase in gaseous product yield over that at 400/sup 0/C. 15 references, 23 figures, 21 tables. « less

Topic: Lignin and Wood Chemistry
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Positioning and Contour Extraction of Autonomous Vehicles Based on Enhanced DOA Estimation by Large-Scale Arrays

As an important branch of Internet of Vehicles (IoV) systems, autonomous vehicle (AV) positioning based on direction-of-arrival (DOA) estimation has received extensive attention in recent years. In this article, an AV positioning method under unknown mutual coupling is proposed within the framework of a large-dimensional asymptotic theory (LAT). First, enhanced and closed-form DOA estimation is achieved by jointly exploiting large-scale uniform linear arrays (ULAs), Toeplitz rectification and the phase transformation result associated with the sample covariance matrix; second, a more reliable subset/set of DOAs is constructed according to the signal-to-noise at receivers; finally, robust AV positioning is achieved with the reliable subset/set. Motivated by satisfactory DOA estimation performance, an AV contour extraction scheme is developed with the aid of two antennas installed on an AV. The proposed method shows several salient advantages compared with existing methods, including improved resolution and accuracy, reduced computational complexity, robustness to mutual coupling and unreasonable DOA estimates, as well as the ability to effectively extract AV contour information.

Topic: Direction-of-Arrival Estimation Techniques
Subfield: Signal Processing
Field: Computer Science
Domain: Physical Sciences