jimnoneill/paper-to-field-training huggingface dataset:
EFFECTS OF 8-LYSINE-VASOPRESSIN AND SYNTHETIC ANALOGUES ON RELEASE OF ACTH

ABSTRACT Two synthetic analogues of vasopressin, [N-α-triglycyl-8-lysine]-vasopressin (GVP) and [1-deamino-8-D-arginine]-vasopressin (DDAVP), with a pronounced and long-lasting pressor and antidiuretic action respectively, were given to healthy volunteers in order to investigate whether the ACTH-releasing ability of vasopressin, reflected by plasma cortisol increase, is related to its pressor or to its antidiuretic effect. The effecti'veness of 3 different intravenous doses of [8-lysine]-vasopressin (LVP) in causing release of ACTH was also studied, and the responses compared with that caused by LVP given intramuscularly, the usually recommended route of administration. The lowest dose of LVP used in this study, 1 μg (0.25 IU) intravenously, caused a significant change of plasma cortisol. Doses of GVP with a pressor effect comparable to that of 8 μg of LVP did not affect the plasma cortisol level significantly in spite of obvious pressor effects. Nor did DDAVP in doses which should exert a maximal antidiuretic effect (4 and 16 μg) increase the plasma cortisol level. In 2 out of 10 subjects, 40 μg of LVP (10 IU) given intramuscularly failed to give a rise in plasma cortisol exceeding 5μg/100 ml, which is generally required for regarding the response as normal, and also 16 μg (4 IU) of LVP intravenously failed to produce a response reaching this level in 1 out of 12 subjects. It is concluded that the ACTH-releasing ability of vasopressin is neither associated with its pressor nor with its antidiuretic action. The finding that normal subjects can have a low response to vasopressin reduces its value for testing the function of the hypothalamic-pituitary – adrenocortical system.

Topic: Neuroendocrine regulation and behavior
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
An analytical method to determine the addendum modification parameters of involute helical gears

Due to the simplified tooth profile and the complicated load distribution along the contact line, the traditional analytic method cannot satisfy the accuracy requirement while carrying out addendum modification of the helical gears. To overcome this disadvantage, a new way based on cross-section method is presented to calculate the deformation of helical tooth tip. First, the tooth is divided into copies of cross-section along face width and the moment of inertia for each section is calculated. Also, the load is distributed according to length of the contact line, and the effect of deflected load is taken into account as well. Based on these works, a general formula of helical tooth tip deformation is deduced. Then, this formula is applied to calculate the addendum modification width a c . In addition, considering that tooth tip modification will shorten the meshing line, three models used to control length of the remaining meshing line are proposed and addendum modification height h c is defined accordingly. Finally, an instance is given to verify the good agreement between results of this study and those of a finite element model. Apart from this, engineering application of this method is provided.

Topic: Gear and Bearing Dynamics Analysis
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
(Invited) Superacid-Surfactant Exchange

Attaining aqueous solutions of individual single-walled carbon nanotubes is the critical first step for harnessing the extraordinary properties of these materials. However, current approaches cause structural damage and cuts the nanotubes into short pieces. In this talk, we will introduce an unexpectedly simple solution to this decade-old challenge by directly neutralizing a nanotube-superacid solution in the presence of a surfactant. This straightforward superacid-surfactant exchange (S2E) involves two simple solution-mixing steps that completely eliminate the need for both ultrasonication and ultracentrifugation. The result allows us to advance multiple fronts, including aqueous sorting of ultralong nanotubes and stretchable thin film transistors with high carrier mobility.

Topic: Chemical Synthesis and Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Dynamics of Phospholipid Molecules in Micelles:  Characterization with Fluorescence Correlation Spectroscopy and Time-Resolved Fluorescence Anisotropy

The dynamic properties of two BODIPY labeled phospholipid molecules in micellar systems have been studied with two different spectroscopic techniques, which provide complementary information (fluorescence correlation spectroscopy (FCS) and time-resolved fluorescence anisotropy (TRFA), respectively). One phospholipid had the fluorescent probe attached to the headgroup (abbreviated as head-labeled) and the other one had the probe at the acyl chain at the sn-2 position of the phospholipid (abbreviated as tail-labeled). From FCS experiments, the translational diffusion constant, aggregation number and hydrodynamic size of the micelles were determined. The micelles were larger in size than reported in the literature, which is due to the incorporation of the relatively large sized fluorescent probe. The FCS results were confirmed by the results of dynamic light scattering experiments on both empty micelles and micelles containing the fluorescent lipid probe. Both results showed that the probe has a very significant effect on the self-assembly behavior. The micelles loaded with the head-labeled phosholipid had a significantly larger radius compared to the micelles loaded with a tail-labeled probe. To obtain more insight into the intramicellar mobility and organization of the fluorescent lipid, TRFA experiments were performed. Analysis of the anisotropy decay showed that the lateral diffusion of the probe is the main, rapid contributing process in detergents such as Triton X-100, polyoxyethylene-9-lauryl ether (Thesit), cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS). However, digitonin and deoxycholate micelles had significantly different properties, which could be explained by more rigidly packed micelles. The calculated values for the wobbling motion, cone angle and order parameters indicated that the tail-labeled probe undergoes less restricted motion than the head-labeled probe.

Topic: Protein Interaction Studies and Fluorescence Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Measuring the effectiveness of research-based curriculum at a university serving a diverse student population

California State University Fullerton is a regional comprehensive university that serves a diverse student population. Over half of the undergraduate students at CSUF are members of minority groups, and just under half spoke a language other than English at home while growing up. We have tested research-based curricular materials, including in courses at CSUF. In some cases, these materials are successful. However, in many cases student outcomes are significantly different from those reported at large research universities. Informally, many faculty believe that the student population at CSUF is significantly different from those at more selective universities. In what ways can the tools of PER be used to measure, describe, and understand the differences between student populations? Are the standard methods of PER suitable for answering questions of this type?

Topic: Diverse Educational Innovations Studies
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
METACHRONOUS BREAST AND RECTAL CANCERS: A CASE REPORT OF SUCCESSFULLY TREATED MULTIPLE PRIMARY MALIGNANT TUMORS

Genetic predispositions, host characteristics, environmental factors and higher cancer patient survival rates are all contributing to the rising prevalence of multiple primary malignant tumors (MPMTs). The global incidence of MPMTs is as high as 11.7%. It is uncommon for MPMTs to affect both breast and rectum. Owing to the scarcity of available literature, there is lack of high-quality evidence that can guide clinicians on the management strategies of this complex oncological entity. In our study, we report a case of successfully treated metachronous tumors of the breast and rectum in a 71-year-old woman. The patient was first diagnosed with moderately differentiated invasive ductal carcinoma of left breast in 2019 for which she underwent modified radical mastectomy (MRM) followed by adjuvant chemo and radiotherapy. In 2021, she was diagnosed with adenocarcinoma of the rectum following multiple episodes of per rectal bleeding. The case was discussed in a multidisciplinary tumor board and after ruling out metastasis, a decision of neoadjuvant chemo-radio therapy followed by anterior resection of the tumor was made. The patient remains disease free so far. In a nutshell, the likelihood of developing a primary second malignancy should always be kept in mind while evaluating a cancer patient. There are no specific guidelines for the management of MPMTs due to the paucity of available data. Therefore, it is imperative that both the patient and the clinician be vigilant for the emergence of new signs and symptoms after the occurrence of index primary malignancy.

Topic: Multiple and Secondary Primary Cancers
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
"Horizontal Bone Augmentation with the Cortical Lamina Technique: A Case Report"

Edoardo Foce and Roberto Rossi* Author Affiliations Torre San Vincenzo 2, 16121 Genova, Italy Received: April 19, 2021 | Published: April 27, 2021 Corresponding author: Roberto Rossi, Torre San Vincenzo, Genova, Italy DOI: 10.26717/BJSTR.2021.35.005693

Topic: Medical and Biological Sciences
Subfield: Anatomy
Field: Medicine
Domain: Health Sciences
“The Whole State Is On Fire”. Criminal Justice and the End of Reconstruction in Upcountry South Carolina1

Le 3 novembre 1876, on trouva les cadavres de deux meuniers allemands dans leur demeure incendiée située à quelques milles de la ville d'Aiken, dans le haut-pays de la Caroline du Sud. Les autorités blanches accusèrent immédiatement cinq Afro-américains de vol, meurtre et incendie volontaire. Leur inculpation, procès et exécution coïncida avec l'élection tendue de 1876 qui s'acheva par la prétendue Rédemption démocrate de la Caroline du Sud. Bien que les républicains fussent majoritaires au parlement de l'État, les racistes Démocrates avaient pris le contrôle de l'appareil judiciaire dans de nombreuses villes de l'État, y compris Aiken. En étudiant une affaire particulière d'homicide, cet article montre de quelle manière les Blancs manipulaient les tribunaux pour appuyer d'une violence légale leur campagne para-militaire contre les Afro-américains. Les procureurs Blancs requirent la peine de mort et, peu de temps après son accession aux fonctions de gouverneur, Wade Hampton approuva l'exécution des condamnés, effectuée en deux fois et qui ressembla à un lynchage, symbolisant l'échec de la Reconstruction.

Topic: Race, History, and American Society
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Using Psychology to Teach Psychology

Research on teacher subject knowledge has shown that teachers need not only knowledge and understanding of the subject they teach, but also how to teach it (Ofsted 2019). This chapter focuses on the importance of using the science of learning in teaching your students. An appreciation of how to manage the cognitive load of students will help them to access the topics and threshold concepts that underpin psychology. Additionally, in order to maximise long term retention of knowledge, we explore how to implement dual coding, spaced practice and the use of retrieval practice to improve students' memory of what they have been taught. All of these strategies will promote higher level thinking in your students as they encourage them to actively think about psychology in new and productive ways.

Topic: Education and Critical Thinking Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Informasi Akuntansi dan Harga Saham Perusahaan LQ45

This paper examine relationship of accounting information and stock price of LQ45 firms. Earnings per share (EPS), book-value per share (BVPS) and net operating cash flow per share (NOCFPS) are used as independent variables and stock price as dependent variable. Hypothesis was tested using balanced panel data set of 23 listed companies included in the LQ45 index during 2013-2017. The result of this study shows that EPS and NOCFPS has a positive effect on stock price, while there is no evidence that BVPS has effect on stock price.

Topic: Financial Analysis and Corporate Governance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Fault diagnosis in district heating networks

Abstract District Heating Networks (DHNs), which dispatch thermal energy from a heat source to end-users by means of a heat carrier, are composed of pipes that can be affected by faults that endanger system reliability. Thus, reliable diagnostic approaches have to be employed to evaluate the health state of the DHN. In the framework of the ENERGYNIUS research project, the authors of this paper developed a diagnostic approach aimed at detecting and identifying the most frequent faults that affect DHN pipes, i.e., water leakages, heat losses and pressure losses. The diagnostic approach detects and identifies pipe faults by coupling a DHN model with an optimization algorithm. As a result, the health indices of each pipe of the DHN, the fault position, its type and magnitude are provided. This study investigates the capability of the diagnostic approach by using two datasets, in which challenging faults were hypothetically implanted in the DHN of the campus of the University of Parma. The diagnostic approach successfully detected and identified both faults, by also accurately assessing fault magnitude. In addition, the relative error with which each DHN variable is predicted is lower than 0.06 %.

Topic: Integrated Energy Systems Optimization
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study

The folding of proteins into their native conformation is a complex process that has been extensively studied over the past half-century. The ribosome, the molecular machine responsible for protein synthesis, is known to interact with nascent proteins, adding further complexity to the protein folding landscape. Consequently, it is unclear whether the folding pathways of proteins are conserved on and off the ribosome. The main question remains: to what extent does the ribosome help proteins fold? To address this question, we used coarse-grained molecular dynamics simulations to compare the mechanisms by which the proteins dihydrofolate reductase, type III chloramphenicol acetyltransferase, and d-alanine-d-alanine ligase B fold during and after vectorial synthesis on the ribosome to folding from the full-length unfolded state in bulk solution. Our results reveal that the influence of the ribosome on protein folding mechanisms varies depending on the size and complexity of the protein. Specifically, for a small protein with a simple fold, the ribosome facilitates efficient folding by helping the nascent protein avoid misfolded conformations. However, for larger and more complex proteins, the ribosome does not promote folding and may contribute to the formation of intermediate misfolded states cotranslationally. These misfolded states persist posttranslationally and do not convert to the native state during the 6 μs runtime of our coarse-grain simulations. Overall, our study highlights the complex interplay between the ribosome and protein folding and provides insight into the mechanisms of protein folding on and off the ribosome.

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Visceral localizations of cat-scratch disease in an immunocompetent patient].

Locoregional expression of cat scratch disease is well known, but despite advances in microbiology over the last 10 years leading to the description of two new bacteria (Afipia felis, Bartonella henselae) the infective agent responsible for cat scratch syndrome remains unknown. Until the 80s, only one systemic disease was attributed to infection with a germ in the Bartonella genus: trench fever. With the onset of the AIDS epidemic, new clinical syndromes caused by Bartonella bacteria have been described: bacillary angiomatosis, hepatic peliosis, cases of recurrent septicemia, cases of endocarditis, etc. More recently, atypical forms of cat scratch disease including systemic diseases have been reported in immunocompetent subjects. Although quite rare (1% of the cases), such types of expression can raise questions as to diagnosis both in terms of clinical signs and in terms of bacteriological findings. Clinical and experimental data do not provide a clear direction for treatment but would suggest that prolonged use of aminoglycosides is useful.

Topic: Bartonella species infections research
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Observer Based Fault Detection and Identification in Differential Algebraic Equations

Fault detection and identification (FDI) are important tasks in most modern industrial and mechanical systems and processes. Many of these systems are most naturally modeled by differential algebraic equations. One approach to FDI is based on the use of observers and filters to detect and identify faults. The method presented here uses the least squares completion to compute an ODE that contains the solution of the DAE and applies the observer directly to this ODE. Robustness with respect to disturbances is also addressed by a frequency filtering technique.

Topic: Fault Detection and Control Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Nanocellulose reinforced polyurethane obtained from hydroxylated soybean oil

In this research, cellulose nanocrystals were successfully obtained from macrocrystalline cellulose and dispersed in a polyurethane matrix Cellulose nanocrystals were characterized by dynamic light scattering. Polyurethane matrix was prepared from hydroxylated soybean oil, tertiary amine catalyst and polymeric diphenyl diisocyanate. Nanocellulose reinforced polyurethane composites were successfully prepared with different concentration and good dispersion of cellulose nanocrystals. Thermal properties and tensile strength of the resulting films were evaluated and dynamic mechanical analysis was carried out. The glass transition temperature of the nanocomposites increased slightly by increasing concentration of nanocellulose. The highest tensile strength was found for the nanocomposite with 1 wt% of cellulose nanocrystals.

Topic: Advanced Cellulose Research Studies
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Gas-Liquid Chromatographic Determination of Sodium 5- [2-Chloro-4- (trifluoromethyl) phenoxy] -2-nitrobenzoate Residues on Soybeans and Foliage, Soil, Milk, and Liver

Abstract Residues of sodium 5- [2-chloro-4-(trifluoromethyl) phenoxy] -2-nitrobenzoate and its free acid are determined by treating a sample extract with diazomethane to convert the residues to methyl 5- [2-chloro-4-(trifluoromethyl)phenoxy] -2-nitrobenzoate. This compound is purified by chromatography on Florisil and measured by electron capture gas-liquid chromatography. The method has been used on soybeans, soybean foliage, soil, milk, and liver. It can detect 0.01 ppm with recoveries of 70–75%.

Topic: Pesticide Residue Analysis and Safety
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Impact of information technology innovation on firm performance in Kenya

Information communication technology (ICT) is driving modern employment creation with networking sites enabling people to interact through innovation. However, ICT uptake and implementation differ due to moderating factors such as entrepreneur innovativeness, which enhances how technology innovation impacts organizational performance. This study examines the association between technology innovation and firm performance in Kenya by considering the impact of entrepreneur innovativeness on this association. A sample of 240 enterprises and structural equation modeling were used in the analysis. The findings indicate that technology innovation influences firm performance positively. The study recommends that entrepreneurs should develop innovative strategies to actualize firm performance. Government policy should aim at improving ICT infrastructure; promoting small and medium-sized enterprises’ (SMEs’) technological externalities within the industry, and establishing ICT resource centers to support SME performance. The study’s findings enrich existing theories and contribute to business management practices in both developed and developing countries.

Topic: Technology Adoption and User Behaviour
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Electrochemistry of (TPP)Mo(O)(OCH3) and (TPP)Mo(O) in dichloromethane

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry of (TPP)Mo(O)(OCH3) and (TPP)Mo(O) in dichloromethaneK. M. Kadish, T. Malinski, and H. LedonCite this: Inorg. Chem. 1982, 21, 8, 2982–2987Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/ic00138a014https://doi.org/10.1021/ic00138a014research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Electrochemical Analysis and Applications
Subfield: Electrochemistry
Field: Chemistry
Domain: Physical Sciences