jimnoneill/paper-to-field-training huggingface dataset:
A Unique Case of Extramedullary Relapse in Acute Lymphoblastic Leukemia: Testicular to Ocular, Cardiac, and Colonic Involvement and the Role of Sperm Phenotyping in Diagnosis—Case Report and Literature Review

Acute lymphoblastic leukemia (ALL) is a malignant condition of lymphoid progenitor cells that primarily affects the pediatric population, but also adults. The 5-year survival rate is 90% in children and approximately 40% in adults, with survival increasing through the use of peripheral stem cell allotransplantation (SCT). The relapse rate after stem cell transplantation (SCT) in adult acute lymphoblastic leukemia (ALL) patients ranges from 35% to 45%, making relapse a major cause of death in this population. Background: We present an atypical case of late testicular involvement in ALL in a 50-year-old man diagnosed with ALL pro-T in remission post-chemotherapy (GMALL 2003 protocol) and allogeneic stem cell transplantation (alloSCT) from a related donor. Methods: This case describes a 50-year-old male with ALL pro-T who experienced three rare extramedullary relapses post-chemotherapy and alloSCT. Five years after remission, he had a unilateral testicular relapse confirmed by immunophenotyping of spermatic fluid. Results: Despite no bone marrow involvement, he was treated with chemotherapy, intrathecal therapy, and bilateral testicular radiotherapy. He later relapsed in the orbit, controlled by radiotherapy, followed by a third relapse in the heart and colon. Conclusions: This case highlights the unusual sites and consecutive nature of extramedullary relapses in adult ALL.

Topic: Acute Lymphoblastic Leukemia research
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Taking Stock: Monetary Policy Transmission to Equity Markets

This paper analyses the effects of U.S. monetary policy on stock markets.We present evidence that individual stocks react in a highly heterogeneous fashion to U.S. monetary policy shocks and relate this heterogeneity to financial constraints and Tobin's q. First, we show that there are strong industry-specific effects of U.S. monetary policy. Second, we also find that for the 500 individual stocks comprising the S&P500 the firms with low cash flows, small size, poor credit ratings, low debt to capital ratios, high price-earnings ratios, or a high Tobin's q are affected significantly more by monetary policy.

Topic: Monetary Policy and Economic Impact
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Authority, Conflict, and the Transmission of Diversity in Medieval Islamic Law * BY R. KEVIN JAQUES

This book employs a professional 'prosopography' (a biography of a professional class of people, in this case a record of the lives of 784 Muslim jurists of the Shafiʿi school of law) written by a fifteenth century Mamluk writer/jurist (Ibn Qāḍī Shuhba (d. 851/1448)) as a source of intellectual and legal history in order to investigate the phenomenon of the decline (or the perception of decline) of legal scholarship and the legal profession in later medieval Islamic history. It is clear, however, that the extent to which decline (or the perception of decline) of social and intellectual life may have occurred in late medieval Islamic history can already be discerned from sources other than (though, according to author, corroborated by) the main source of this study. For example, the author reminds us that forms of the decline of the Islamic culture may have begun from the twelfth century where 'in 589/1193 conditions were so abhorrent that when famine struck in Iraq people resorted to cannibalism' (p. 5).

Topic: Islamic Studies and History
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Genetically motivated clusters within Atlantic

Abstract This chapter discusses the extent to which Atlantic can be considered a genetic unity. The short answer to the question is, ‘No, it cannot.’ A full answer, however, is more complex and requires considering the history of Atlantic classification, (European) linguistic traditions, and language ideologies. An obvious and agreed-upon first split is between North and South Atlantic, which is no longer a split since the two are no longer considered related. North Atlantic itself has been decomposed into distinct genetic entities, and Bijogo, once thought to be an isolate, is now considered part of one of those entities. The depth of the classification in terms of hierarchical levels with subgroups and various nestings now seems an increasingly unrealistic possibility for Atlantic and perhaps for other, similarly disparate groups as well. Classification with any depth cannot be supported by the presently available evidence. What can be argued for, then, is a more atomized and flatter structure than the familiar ones of the past. What once was monolithic Atlantic must be broken up into different subgroups, which may not be relatable to each other in any traditional way but do possess some local cohesion.

Topic: Coastal and Marine Management
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
Cable TV: Bringing Home Native Speaker to Increase Listening Comprehension of the Students of English Education Department Teacher Training and Education Faculty Muria Kudus University

This study investigated the use of cable TV to increase listening comprehension of the students of English education department of Muria Kudus University. The aims were to find out: (1) the listening comprehension achievement of the students taught by using cable TV, (2) the students’ response towards the teaching of listening comprehension class by using cable TV, and (3) the students’ difficulties when being involved in the listening class taught by using cable TV are. A classroom action research was conducted with three cycles. The data was collected by using test, observation checklist, &amp; a questionnaire. The subject consisted of 29 students joining Advanced Listening class. The findings show that: (a) The listening comprehension achievement of the students taught by using cable TV in cycle I, II, &amp; III is fair, (b) The students have enthusiasm and seriousness and motivation in joining the class in all cycles, (c) In cycle III the students’ difficulties when being involved in the listening comprehension class taught by using cable TV are more and more decreasing. Keywords: Cable TV, Listening ComprehensionKeywords;Cable TV; Listening Comprehension

Topic: English Language Learning and Teaching
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Popular Culture

Abstract “Popular culture” relates to markets. Neoclassical economics assumes that expressions of the desire and capacity to pay for services stimulate the provision of entertainment and hence – when the result is publicly accepted – determine what is “popular.” Value is decided through competition between providers to obtain the favor of consumers, with the conflictual rationality of the parties producing value to society. The connection of market entertainment to new identities leads to a variety of sociological reactions. During the Industrial Revolution, anxieties about a suddenly urbanized and educated population saw theorists from both right and left argued that newly literate publics would be vulnerable to manipulation by demagogues. The subsequent emergence of public schooling in the west took as its project empowering, and hence disciplining, the working class. This notion of the suddenly enfranchised being bamboozled by the unscrupulously fluent has recurred throughout the modern period. It inevitably leads to a primary emphasis on the number and conduct of audiences to popular culture: where they came from, how many there were, and what they did as a consequence of being present.

Topic: Cultural Industries and Urban Development
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
Identification of chemoresistance-associated miRNAs in hypopharyngeal squamous cell carcinoma

This study aimed to determine candidate miRNAs that could help to evaluate whether patients with hypopharyngeal squamous cell carcinoma (HSCC) would benefit from docetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy. We downloaded the expression profiles of HSCC patients from the Gene Expression Omnibus database. miRNA profiles were analyzed via Principal Components Analysis (PCA), followed by Linear Discriminant Analysis (LDA). The Database Annotation for Visualization and Integrated Discovery tool was utilized for enrichment analysis; STRING and Cytoscape were used for network construction. We detected that hsa-miR-15b-5p, hsa-miR-93-5p, and hsa-miR-130a-3p might act as crucial regulators in chemoresistance of HSCC, and they may play as prognosticators and therapeutic targets in the future. [Med-Science 2020; 9(1.000): 160-3]

Topic: MicroRNA in disease regulation
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Reconstruction of the Regulation of Criminal Responsibility of Perpetrators towards Victims of Criminal Acts Based on Restorative Justice

Criminal acts according to the Restorative Justice perspective, are violations against humans and relations between humans. This research’s objectives aim to: 1) examine regulations on criminal liability not yet based on restorative justice; 2) identify weaknesses in current regulations; and 3) propose a reconstruction of criminal liability regulations based on restorative justice principles. The research method uses the positivist paradigm, with a socio-legal research approach method, and a descriptive research type. The type and source of data uses secondary data in the form of primary legal materials, secondary legal materials, and tertiary legal materials. The data collection method uses literature, and qualitative analysis methods. The research results are: 1) The regulation of criminal liability for perpetrators toward victims is not yet based on restorative justice, with court proceedings still aimed at deterrence through imprisonment; 2) Current weaknesses include: in legal substance, the litigation process is long, rigid, costly, and fails to restore the harm or reflect community justice; in legal structure, law enforcement is bound by rigid regulations, with unclear coordination, limited capacity, and weak commitment; in legal culture, positivistic legal views dominate, limiting flexibility and fairness in criminal justice; 3) The study proposes reconstruction of criminal liability regulations based on restorative justice. This includes shifting from a punitive to a restorative approach, focusing on healing and accountability, and updating key regulatory frameworks. Specifically, it involves revising values and norms in the Regulation of the Attorney General of Indonesia No. 15 of 2020 Article 6 on Termination of Prosecution Based on Restorative Justice, and the Regulation of the National Police No. 8 of 2021 Article 1, Point 3 on the Handling of Criminal Acts Based on Restorative Justice, to better integrate restorative principles into law enforcement and prosecution practices.

Topic: Education, Law, and Society
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
A study of skin characteristics according to humidity during sleep

Abstract Introduction During sleep, the skin is exposed to various environments for example low or high humidity and temperature. And the average of 7‐8 hours of sleeping in those situations can affect skin condition. Therefore, the objective of this study was to determine skin characteristics according to humidity during sleep. Method Eleven healthy women in their ages of 20s and 30s were controlled. They slept more than 7 hours at lower than 30% relative humidity ( RH ) environment on the first day and at higher than 70% on the second day. The room temperature was controlled to 22 ± 5°C. Three measurement points were (a) before for sleep (after wash), (b) after 7 hours sleep (morning), and (c) after wash. Skin hydration, sebum secretion, and trans‐epidermal water loss ( TEWL ) were measured. The statistical significance was determined at P &lt; 0.05. Result After 7 hours of sleep in 30% RH condition, skin hydration decreased by 24.23% significantly, but there was no significant difference after sleeping in 70% RH . The sebum level was increased after sleep at 30% RH . The TEWL did not show differences according to the humidity during sleep but significantly increased after facial cleansing in 30% RH sleeping condition. Discussion In this study, we confirmed that the changes in skin characteristics may be affected by humidity during sleep. When sleeping in dry environment, skin hydration decreases but the amount of sebum increases to compensate for skin dryness. Therefore, this study might suggest how to care the skin before sleep depending on the room humidity.

Topic: Dermatology and Skin Diseases
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Optimization on Safety Thickness of Roof for Mining Based on Genetic Algorithm

According to optimization on safety thickness of roof for underground mining, which is a complex problem affected by multiple factors. On the basis of Genetic Algorithm (GA), each influencing factor on safety thickness of roof is considered as different gene and used to express individual composition factor of population. Therefore, each arbitrary group composed by different influencing factors can be used as a population. Then, by constructing objective function, designing optimization variables and determining constraint condition, the mathematical model of optimization on safety thickness of roof can be constructed. By using the Evolver software, which is based on the thought of GA, the optimization on safety thickness of roof for stopping the orebody No.92, under the overlap zones in Tongkeng Mine, is studied. The optimized results show that more conformable and accurate of the safety thickness of roof compared with the results obtained by numerical simulation and mathematical prediction.

Topic: Rock Mechanics and Modeling
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells.

Epigenetic modifications of DNA, such as the promoter CpG island demethylation of tumor suppressor genes, might be related to the protective effect of soy on prostate cancer.

Topic: Epigenetics and DNA Methylation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
On-line LoadOptimization forTwoWayLoadManagement System

In thispaper,an optimization approachis proposedforthecontrol centerinthetwo way load management system tocoordinate thedirect control ofalarge numberofcentral chillers. Theoptimization approach iscalled therealtimetwo way direct loadcontrol algorithm (RTDLCA),whichfinds thesuitable central airconditioning customers tocontrol byinteger programming. TheRTDLCA calculates thefollow uploadtoshedbased onthemonitored air conditioning loadandminimizes thedifference between theload planned tobeshedandtherealloadhasbeenshed.Thetime lagging ofloadvariations ofeverychiller undercontrol aswell asloadprofiles being sentbackviabroadbandnetworkis considered andissignified inRTDLCA. I.INTRODUCTION TaiwanPowerCompany (TPC) bears heavier loadinthe summer because ofhigher demand ofair condition usage. Duetoelectric deregulation, TPChasbeenexecuted Direct LoadControl (DLC)ofairconditioning load viaradio signals program (1)innorthern Taiwan formanyyears. After signing agreements withits customers, TPCinstalls aradio switch on eachofthecustomer's airconditioners. Thisprogram sends signals tocustomers executing DLC toshedtheair conditioners viaradio paging load management system. The control center oftheradio paging load management system cannot obtain theresults ofloadshedding after DLCbecause theradio paging loadmanagement system isa oneway remote control system. TPCcanonly install arecord meterin customer side anddownload theloading profile frommeter bystaff withdata collector during certain timewhether itis used toresponse customer shed. Airconditioners areaffected byairtemperature, setting ofairconditioners andheating load ofthecontrolled environment. Thecontrol center cannot gain thereal shedding capacities whenitsends every signal of theshedcommand. Because ofthestability, high bandwidth andhighspeed, broadband networks aregetting moreandmorepopular. Subscribers ofAsymmetric Digital Subscriber Line(ADSL) ofthepublic service broadband fixed networks inTaiwan are increasing inrecent years. Infact, thedensity ofADSL subscribers ranks Taiwan thesecond intheworld. In ordertoinvestigate thepossibility ofbuilding multi-purpose customer service system, TPChasinitiated the project ofdesigning BROadband Network basedUtility customer Service System. (BRONUSS)since 2000.The computer program installed inthecomputer ofcontrol center iscalled Integrated Customer service andDemandside

Topic: Smart Grid Energy Management
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Two-dimensional spatial optical solitons in bulk Kerr media stabilized by self-induced multiphoton ionization: Variational approach

The beam parameters of spatial two-dimensional solitons in a bulk medium under the influence of the combined effects of diffraction, Kerr nonlinearity, and nonlinear index change by plasma creation will be studied with the help of a variational approach. A simple analytical relation for the power of a spatial two-dimensional soliton is derived which shows a two-valued behavior in dependence on the beam diameter. The variational approximation is compared with numerical and experimental results. The solution is proven to be stable against small perturbations in the whole parameter region. \textcopyright{} 1996 The American Physical Society.

Topic: Nonlinear Photonic Systems
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Causes of Blindness and Visual Impairment in Early Childhood at a Low Vision Service in Mexico City: A 15-year Review

<b>Purpose</b>: To evaluate the causes of blindness and visual impairment in children aged 0-7 years attending a Low Vision Centre in Mexico City, Mexico.<b>Methods</b>: Clinical records for patients aged 0-7 years attending the Centre from 2001 to 2015 were retrospectively reviewed. Causes of blindness and visual impairment, affected anatomy, and suspected time period of insult were recorded.<b>Results</b>: 1487 patients were included, 45.9% girls and 54.1% boys. Mean age of presentation was 39 months (SD 27.9 months). 36.0% had associated co-morbidities in addition to their ophthalmic pathology. 39.7% presented with developmental or psychomotor delay. Leading diagnoses were Retinopathy of Prematurity (ROP) (19.6%), optic nerve atrophy (11.5%), and congenital cataract (9.5%). The most affected anatomical regions were retina (33.8%), optic nerve (16.6%), and lens (10.5%). Half of all cases (50.9%) had insults in the prenatal period. Children with developmental delay were more likely to present before the age of one. There is a significant difference in risk of delayed presentation according to diagnosis. Only 13.5% of children with optic nerve atrophy presented to the Centre before the age of one, compared to 28.4% of children with ROP and 23.4% of children with cataract.<b>Conclusion</b>: The most common diagnoses for blindness and visual impairment among children were ROP, optic nerve atrophy, and congenital cataract. Late presentation to the Centre was common. There were significant differences in risk of delayed presentation depending on diagnosis. Co-existing systemic conditions and developmental and psychomotor delay were also common among patients attending the Centre.

Topic: Retinopathy of Prematurity Studies
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Purported Self-Organized Criticality of the Cardiovascular Function: Methodological Considerations for Zipf’s Law Analysis

Self-organized criticality is a universal theory for dynamical systems that has recently been applied to the cardiovascular system. Precise methodological approaches are essential for understanding the dynamics of cardiovascular self-organized criticality. This study examines how the duration and quality of data recording affect the analysis of cardiovascular self-organized criticality, with a focus on the beat-by-beat heart rate variability time series obtained from seven healthy subjects in a standing position. Drawing a Zipf diagram, we evaluated the distribution of cardiovascular events of bradycardia and tachycardia. We identified tipping points for the distribution of both bradycardia and tachycardia events. By varying the recording durations (1, 2, 5, 10, 20, 30, and 40 min) and sampling frequencies (500, 250, and 100 Hz), we investigated their influence on the observed distributions. While shorter recordings can effectively capture cardiovascular events, they may underestimate the variables describing their distribution. Additionally, the tipping point of the Zipf distribution differs between bradycardia and tachycardia events. Comparisons of the distribution of bradycardia and tachycardia events should be conducted using long data recordings. Utilizing devices with lower sampling frequencies may compromise data fidelity. These insights contribute to refining experimental protocols and advancing our understanding of the complex dynamics underlying cardiovascular regulation.

Topic: Complex Systems and Time Series Analysis
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
ChemInform Abstract: Preparation and Characterization of a Macrocyclic Fulleropyrrolidine.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Fullerene Chemistry and Applications
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Optimal Speed Tracking Control of PMSM via Inverse Optimal Composite Controller

This brief proposes an inverse optimal composite (IOC) speed regulation controller for a permanent magnet synchronous motor (PMSM) system, simultaneously providing optimality and robustness. We regard the unknown load torque related term as a mismatched disturbance and design a disturbance observer to obtain its estimated value. Then, by constructing control Lyapunov function, inverse optimal control is obtained with consideration of disturbance estimation, avoiding solving Hamilton-Jacobi-Bellman equations. Finally, simulation results and experimental validation show the effectiveness and superiority of the proposed IOC control method in the speed tracking process of PMSMs.

Topic: Adaptive Control of Nonlinear Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences