jimnoneill/paper-to-field-training huggingface dataset:
Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children

We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxymetronidazole (MET-OH) from only 50 µL of human plasma, and unbound CEF from 25 µL plasma ultra-filtrate to evaluate the effect of protein binding. Cefuroxime axetil (CEFU) was used as an internal standard (IS). The analytes were extracted by a protein precipitation procedure with acetonitrile and separated on a reversed-phase Polaris 5 C18-Analytical column using a mobile phase composed of acetonitrile containing 0.1% (v/v) formic acid and 10 mM aqueous ammonium formate pH 2.5, delivered at a flow-rate of 300 µL/min. Multiple reaction monitoring was performed in the positive ion mode using the transitions m/z555.1→ m/z396.0 (CEF), m/z172.2→ m/z 128.2 (MET), m/z188.0→ m/z125.9 (MET-OH) and m/z528.1→ m/z 364.0 (CEFU) to quantify the drugs. Calibration curves in spiked plasma and ultra-filtrate were linear ( r 2 ≥ 0.9948) from 0.4-300 µg/mL for CEF, 0.05-50 µg/mL for MET and 0.02 - 30 µg/mL for MET-OH. The intra- and inter- assay precisions were less than 9% and the mean extraction recoveries were 94.0% (CEF), 98.2% (MET), 99.6% (MET-OH) and 104.6% (CEF in ultra-filtrate); the recoveries for the IS were 93.8% (in plasma) and 97.6% (in ultra-filtrate). The validated method was successfully applied to a pharmacokinetic study of CEF, MET and MET-OH in hospitalized children with complicated severe acute malnutrition following an oral administration of MET and intravenous administration of CEF over the course of 72 hours.

Topic: Antibiotics Pharmacokinetics and Efficacy
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
[Angiography of the orbit (author's transl)].

Advances in angiography of the orbit are presented. Angiography is done by selective catheterisation of the internal carotid artery or of the branches of the external carotid artery supplying the periorbital area. Since the procedure is done without heavy sedation or even general anesthesia, the patient can follow instructions and move his eyeballs or open or close his eyelids if wanted for the procedure. Magnification angiography and subsequent subtraction is necessary to obtain good images of the globe permitting visualisation of even the smallest vessels in the choroid layer.

Topic: Ophthalmology and Eye Disorders
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Influence of limiting beliefs in soft employability skills

The purpose of this paper is to identify the main soft skills demanded by the hospitality industry, under the perception of master´s degree students and the influence of limiting beliefs in skills development. After a literature review, we lead a fieldwork based on workshops in which we conducted two questionnaires and we analyze the behaviour of students through the method of tutor observation. The results show a relationship between their soft-skills, and a significative negative correlation between perceived skills and the limiting beliefs. With this exploratory paper, we try to contribute to the better knowledge of new factors that may be hindering the development of the soft skills demanded in postgraduate students in the hospitality sector. These preliminary conclusions can be useful for both postgraduate schools and companies in their selection and training processes.

Topic: Hospitality and Tourism Education
Subfield: Tourism, Leisure and Hospitality Management
Field: Business, Management and Accounting
Domain: Social Sciences
Propagation of Radio Signals in V2V/V2I Communications

These Approach the data transmission/reception problems in radio environment by Communication Automotive version 1.0. (CommA_v.1.0.) system with using RFM12B radio module, by simulating various meteorological phenomena, brings a new vision on the way of radio communication in this field on these frequency bands. Significant reduction in radio signal propagation due to weather phenomena, which helps to monitor vehicle behavior and infrastructure in these cases.

Topic: Energy Harvesting in Wireless Networks
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Selection of high yield recombinant human bone morphogenetic protein 2 (rhBMP2) cell pool based on different screening markers used for CHO cell line development

The Chinese hamster ovary (CHO) cell line is a typical host for the production of therapeutic proteins, which can be genetically manipulated to express glycoproteins with correct assembly. Recombinant human bone morphogenetic protein 2 (rhBMP2) is an osteogenic therapeutic option that is often produced in CHO cells. In this work, two common host strains, CHO-K1 and CHO-DG44, were used for the production of rhBMP2. CHO-K1 cells were cultured and transfected with the EGFP/NeoR and rhBMP2/NeoR expression vectors via the CRISPR/Cas9 method, which targets the Hipp11 locus of the host genome. Similarly, CHO-DG44 cells were cultured and transfected with the rhBMP2/DHFR vector. Recombinant rhBMP2 cells were screened using the neomycin resistance gene in CHO-K1 cells and the dhfr gene in CHO-DG44 cells. The surviving recombinant cells were expanded, and then expression of rhBMP2 were analyzed by ELISA. The level of rhBMP2 expression in the recombinant cell pools revealed the importance of efficiency of the screening strategy and genome editing method. In conclusion, the use of an appropriate strain of host cell and efficiency of selective markers can affect the recombinant protein expression that is important for the industrial pharmaceutical production.

Topic: Viral Infectious Diseases and Gene Expression in Insects
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Synthesis of Phospholipids and Triglycerides in Human Liver Slices I. Experimental Conditions and the Synthesis Rate in Normal Liver Tissue

AbstractHuman liver slices were incubated with glycerol-1,3-14C or fructose-U-14C. 50% of the label was recovered as glucose and 10% was incorporated into CO2 and into lipids, respectively. At high fatty acid concentration in the medium the incorporation into CO2 and glucose was suppressed, into triglycerides increased, and into phospholipids unchanged. The incorporation of fructose was suppressed with glycerol in the medium. The mean synthesis rate for phospholipids was 0.14 ± 0.01 μmoles/g liver per hour and for triglycerides 0.34 ± 0.04 μmoles/g liver per hour.Key Words: Fructose-U-14Clipid synthesisglycerol-1,3-14Clipid synthesisglycerol metabolismliverlipid metabolismliver slicesphospholipid synthesislivertriglyceride synthesisliver

Topic: Metabolism and Genetic Disorders
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Cardiac causes of death in Moscow and Moscow Region

Rationale: Cardiovascular disorders play a leading role in populational mortality, but they are not synonymous to cardiac pathology. The city of Moscow and the Moscow Region are one of the biggest urban agglomeration worldwide.Aim: Analysis of cardiac-related mortality in Moscow and the Moscow Region.Materials and methods: We calculated standardized mortality coefficients (SMC) for 23 death causes given as separate lines in the Short List of Death Causes by the Russian Agency of Statistics (Rosstat) in 2019.Results: In 2019, SMC for cardiac causes was 171.2 per 100 000 of the population in Moscow (27.6% of all causes) and 248.7 per 100 000 of the population in the Moscow Region (26.9% of all causes). More than 60% of deaths both in Moscow and in the Moscow Region were caused by chronic variants of ischemic heart diseases, whose criteria are not well-defined or are absent. In Moscow, SMC for myocardial infarction is significantly lower, whereas that for unspecified cardiomyopathy (the code by International Classification of Diseases and Health-related Conditions, version 10 (ICD10) I42.9) is higher. SMC from the groups of death causes related to chronic illness possibly unrelated to atherosclerosis, are comparable: 29.64 in Moscow and 24.59 in the Moscow Region. SMC from arterial hypertension (ICD10 I10-13) are 8.7 and 5.6 per 100000 of the population, respectively.Conclusion: Despite higher total cardiac mortality in the Moscow Region, SMCs for individual death causes in Moscow are significantly higher. SMC variability is mostly related to different algorithms for determination of primary death cause. ICD10 and the Rosstat the Short List of Death Causes seem to be suboptimal sources to understand the contribution of cardiac causes into the mortality structure. Any correct comparison would become possible after a consensus of expert positions by specialists in Moscow and Moscow Region on the criteria of diagnosis, choice of primary death cause and corresponding disease code.

Topic: Healthcare Systems and Public Health
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Supply chain sales forecasting based on lightGBM and LSTM combination model

Purpose The purpose of this paper is to design a model that can accurately forecast the supply chain sales. Design/methodology/approach This paper proposed a new model based on lightGBM and LSTM to forecast the supply chain sales. In order to verify the accuracy and efficiency of this model, three representative supply chain sales data sets are selected for experiments. Findings The experimental results show that the combined model can forecast supply chain sales with high accuracy, efficiency and interpretability. Practical implications With the rapid development of big data and AI, using big data analysis and algorithm technology to accurately forecast the long-term sales of goods will provide the database for the supply chain and key technical support for enterprises to establish supply chain solutions. This paper provides an effective method for supply chain sales forecasting, which can help enterprises to scientifically and reasonably forecast long-term commodity sales. Originality/value The proposed model not only inherits the ability of LSTM model to automatically mine high-level temporal features, but also has the advantages of lightGBM model, such as high efficiency, strong interpretability, which is suitable for industrial production environment.

Topic: Forecasting Techniques and Applications
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Divergences of Opinion and Long Term Performance of Post Stocks Initial Public Offerings at Indonesia Stock Exchange

This study examines and analyzes the effect of divergence of opinion on long-term performance of stock post IPO with initial return control variable, firm size, offering size, reputation of underwriter and return on equity. The study was conducted using 2004-2013 data, with 157 IPO companies in Indonesia capital market. The test is done by using multiple linear regression. The results of this study found that the divergence of opinion has a positive effect on the long-term performance of post-IPO shares. This occurs in the long-term performance period of post-IPO shares with an abnormal cumulative measurement of return12 months, 24 months. The result of opinion divergence regression and variable of all control with long term performance of stock post IPO revealed significant result at period of 12 months and 36 months. By measuring the buy and hold of abnormal returns, the opinion regression divergence with the long-term performance of post-IPO shares is significant in the 12-month period. The regression result of opinion divergence and all control variables with long-term performance of post-IPO shares is significant in the period of 12 months and 24 months. Variable characteristics of companies that are considered by investors in IPO stock transaction are firm size, initial return, offer size and reputation of underwriter. The implication of this study shows that risk factors play an important role in long-term performance of post-IPO shares.

Topic: Financial Analysis and Corporate Governance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Field Corn, European Corn Borer Control, 1983

Abstract Insecticides were applied through two electric center-pivot irrigation systems for control of first generation European corn borer larvae in field corn. Insecticides were injected into the irrigation water by a PULSA feeder MICROFLO 680 diaphram metering pump. Water volume was ca 0.30 in. The oil tank mixed with three of the treatments was SUNOCO UN. Experimental design was randomized complete block with four replications and plot size was ca 10 acres. In early Aug., 10 plants at 5 different locations within each replicate were split in half from the tassel to the ground, examined, and the number of corn borer cavities recorded. Yields were determined by hand harvesting 0.001/acre strips at six different locations within each replicate.

Topic: Insect Resistance and Genetics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
REINTERPRETASI MANTRA DALAM INSKRIPSI PENDEK CANDI SANGGAR

The relation between archeology and philology studies is related to studies of relief and epigraphy. In the construction of the temple, it is usually followed by the carving of Javanese literary stories in the relief of temples in Java. During the period of Majapahit's political decline, there was an increase in the number of shrines in the mountains of Java. The end of Majapahit's power became an important time frame as a marker of the cultural transformations. This study will present a re-reading of inscriptions at Candi Sanggar, a temple located on the slopes of Mount Bromo. The approach used in this research is Philoarchaeology. An archaeological perspective on artifacts and manuscripts. This research attempts to treat, describe, and interpret as text that reflects the supporting culture. Previous research, short inscriptions of Candi Sanggar only places as letters and languages. It is certainly open to other readings, putting its inscription as an arrangement of numbers or symbols. A less comprehensive study would lead to misinterpretation. So this paper places Candi Sanggar's short inscriptions in interpretation by considering philological studies, mainly on Budamtexts. This papper considers the paleographic study by aligning the Sanggar Temple inscriptions with the Merapi-Merbabu collection texts. The results of this study revealed that the short inscriptions at Sanggar Temple could be compared to the rules of Sengkalan Dihyang. The conclusions of Candi Sanggar inscriptions are Sengkalan Dihyang which reads 75 (1,3), 55 (3,5), 67 (3,3), 57 (3,2). Keywords: Sanggar Temple, Bromo, Paleografi, Merapi Merbabu, Sakala Dihyang.

Topic: Cultural and Artistic Studies
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Before Orbis Pictus : some notes on Comenius' Latin textbooks

The authors of the current paper study Latin textbooks written by J. A. Comenius before his Orbis pictus (1658).In attempt to explain book title Janua linguarum reserata they draw reader's attention both to the real history of its composition and to its possible symbolic interpretation.Close attention is paid to Vestibulum, the first textbook of the series Vestibulum -Janua -Atrium, intended for children of six-seven years old.It is argued, that it was a figure of king Solomon and his personified Wisdom that stood behind the general layout of Vestibulum determining its title, its first chapter and more (particularly, a paragraph on numerals is analyzed in details).The authors make a try to find allusions to New Testament in Janua and Vestibulum and to trace indirect influence of some pericopes from Scripture on Comenius' textbooks.Unconsciously, the philosopher of the XVIIth century was bound to biblical tradition coining phrases and verbal images that had implicitly inherited patterns from the Holy Bible.

Topic: Historical and Literary Analyses
Subfield: Literature and Literary Theory
Field: Arts and Humanities
Domain: Social Sciences
Supplementary Material for: Effect of CPP-ACP added to Milk, Chewing Gum and Candy on Dental Caries: a Systematic Review

Casein is one of the most studied proteins with activity against dental caries. In particular, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has shown promising remineralizing properties. In vivo evidence on the anticaries potential of CPP-ACP added to foodstuffs is elusive, nonetheless. Hence, this systematic review aimed at determining whether the use of CPP-ACP added to foodstuffs has a remineralizing or inhibitory action on dental demineralization either in vivo or in situ. The review protocol followed the PRISMA-P criteria and was registered in PROSPERO. PubMed, SCOPUS, and Web of Science databases were searched using predefined criteria, based on the PICO question; Is there an effect on dental caries upon adding CPP-ACP to milk, chewing gums, or candies? No year or language limits were applied. Article selection and data extraction were carried out independently by 2 investigators. Two hundred-ten titles were examined, 23 selected for full-text review and 16 studies included (2 in vivo, and 14 in situ). In 2 studies, CPP-ACP was added in candy, in 2 to milk and in 12 to chewing gum. The main outcomes included enamel remineralization and activity against dental biofilm. The overall quality of the evidence was classified as moderate. The available evidence suggests that CPP-ACP added to milk, chewing gum or candy has a potential remineralizing activity on tooth enamel, with some additional antibacterial activity on the dental biofilm. Further clinical studies are needed to verify if this effect is clinically significant in reducing the caries lesion incidence or to revert the demineralizing process.

Topic: Dental Erosion and Treatment
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
<i>XPD</i> and <i>XRCC1</i> Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

Purpose Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with platinum agents for non–small-cell lung cancer (NSCLC). Methods We used polymerase chain reaction–restriction fragment length polymorphism to evaluate genetic polymorphisms of the XPD (Asp312Asn) and XRCC1 (Arg399Gln) DNA repair genes in 103 patients with stage III (54%) and IV (46%) NSCLC treated with platinum-based chemotherapy. Results Median age was 58 years (range, 32 to 77 years), 49% were females, and there were 86 deaths. Median follow-up period was 61.9 months. Median survival time (MST) was 14.9 months; by stage, MST was 28.6 months (IIIA), 16.0 months (IIIB), and 9.3 months (IV). Genotypes were not associated with stage. Increasing numbers of either XPD or XRCC1 variant alleles were associated with shorter overall survival (P = .003 and P = .07, respectively, by log-rank test). Similarly, when we compared combinations of variant alleles across both polymorphisms, we found that a greater number of variant alleles was associated with decreasing overall survival (P = .009, log-rank test). These polymorphisms independently predicted overall survival even after taking into account stage, performance status, and chemotherapy regimen. Conclusion Genetic polymorphisms in XPD and XRCC1 may be important prognostic factors in platinum-treated patients with advanced NSCLC.

Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Traffic Accident Scene Drawing System Based on Image Trapezoid Distortion Correction

The traffic accident scene drawing system provides a system and method for drawing a traffic accident automatically. With the help of our digital information system, it can create a professional sketch through just a few mouse clicks and can measure the distance of vehicles by some accident images. The apple ios not only inherits the MAC OS X system’s image processing function which realized the image correction and maintained image information better, but also makes the operation control touch screen interface well. The system has realized the collection of photos, graphics, image information processing, setting the scene of the accident report into an organic whole, improving the accuracy of the drawing and the efficiency of the traffic accident treatment.

Topic: Simulation and Modeling Applications
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Systemic Review of the Feasibility and Advantage of Minimally Invasive Pancreaticoduodenectomy

Abstract Background Minimally invasive pancreaticoduodenectomy (MIPD), which includes laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is a complex procedure that needs to be performed by experienced surgeons. However, the safety and oncologic performance have not yet been conclusively determined. Methods A systematic literature search was performed using the Embase, Medline, and PubMed databases to identify all studies published up to March 2015. Articles written in English containing the keywords: “pancreaticoduodenectomy” or “Whipple operation” combined with “laparoscopy,” “laparoscopic,” “robotic,” “da vinci,” or “minimally invasive surgery” were selected. Furthermore, to increase the power of evidence, articles describing more than ten MIPDs were selected for this review. Results Twenty‐six articles matched the review criteria. A total of 780 LPDs and 248 RPDs were included in the current review. The overall conversion rate to open surgery was 9.1 %. The weighted average operative time was 422.6 min, and the weighted average blood loss was 321.1 mL. The weighted average number of harvested lymph nodes was 17.1, and the rate of microscopically positive tumor margins was 8.4 %. The cumulative morbidity was 35.9 %, and a pancreatic fistula was reported in 17.0 % of cases. The average length of hospital stay was 12.4 days, and the mortality rate was 2.2 %. Conclusions In conclusion, after reviewing one‐thousand cases in the current literature, we conclude that MIPD offers a good perioperative, postoperative, and oncologic outcome. MIPD is feasible and safe in well‐selected patients.

Topic: Pancreatic and Hepatic Oncology Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Captive reproduction in Heermann's kangaroo rat, <i>Dipodomys heermanni</i>

Abstract This paper summarizes 8 years of captive breeding experience with the endangered Morro Bay kangaroo rat ( Dipodomys heermanni morroensis ) and the non‐endangered Lompoc kangaroo rat ( D. h. arenae ), a related form used as a surrogate. Kangaroo rats are aggressive and must be caged individually; copulation can only take place when the female is in estrus. The estrous cyle varies, but is usually 14–17 days long; gestation averages 31 days. Data on development of the young, animal health, mortality, and longevity are presented. The productivity of this project is compared with that of another long‐term kangaroo rat breeding project in terms of the number of young produced per female per year. A captive breeding program can be initiated with 40–50 reproductive animals as a founder group.

Topic: Rabbits: Nutrition, Reproduction, Health
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences