jimnoneill/paper-to-field-training huggingface dataset:
Studies on improvement of pharmaceutical preparations prescribed in hospitals. V. Nifedipine hollow type suppository.

Nifedipine is a calcium antagonist used for the treatment of hypertension and angina pectoris. However, commercial nifedipine preparations are only available in forms suitable for oral administration, e.g. soft capsules and tablets. Therefore, we developed a suppository form in which the drug was incorporated into a hollow type suppository. The suppository preparation was administered to humans for evaluation of the clinical and commercial usefulness. It was as fast-acting as the soft capsule, but the blood concentration of nifedipine immediately after administration was lower than that seen with the soft capsule. It was considered to be superior to the soft capsule and similar to the tablet in terms of its long-acting effect. Thus, the hollow type suppository form of nifedipine should have useful clinical applications.

Topic: Pharmacy and Medical Practices
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Imaging mechanism of the holographic recording material dichromated cellulose triacetate

Dichromated cellulose triacetate (DCCTA), a new, to our knowledge, holographic recording film, is presented. The material has some special properties, such as good environmental stability, a stronger real-time effect, strong relief modulation, a stratified sensitivity without the use of any coating technique, a light weight, flexibility, easy fabrication in a large area, and more. By the systematic study of the physicochemical changes of the microstructure of DCCTA in photochemical reaction processes with an electron paramagnetic resonance spectrometer, an infrared spectrometer, an UV spectrophotometer, and interferometric microscopy, we found that, as a dichromated light-sensitive system, DCCTA has a novel imaging mechanism: Light irradiation causes not only the formation of the cross links between Cr(3+) and molecular chains but also the decomposition of the main molecular chains of the film. In the real-time imaging process of DCCTA holograms the former plays a dominant role after the holograms are postprocessed; however, the latter is more important in the imaging process, and the holograms exhibit a positive etching property, which differs completely from that of other well-known dichromated materials, such as dichromated gelatin and dichromated poly(vinyl) alcohol.

Topic: Photorefractive and Nonlinear Optics
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Role of Corticosteroid Regimen On Adrenal Suppression Debated

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal

Topic: Adrenal Hormones and Disorders
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Appendicitis in a Preterm Infant with Incarcerated Inguinal Hernia

We report a case of appendicitis and incarcerated inguinal hernia in a preterm triplet with Enterococcus faecalis sepsis. After a course of antibiotic treatment for three days, the four week old boy presented with a distended abdomen and right groin swelling due to a suspected incarcerated hernia. Surgical examination revealed an incarcerated inflamed appendix inside an inguinal hernia.

Topic: Appendicitis Diagnosis and Management
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Variations in Plasma Thyroxine Concentrations Throughout One Year in Penned Sheep on a Uniform Feed Intake

Plasma total thyroxine (T 4) concentrations were measured by radioimmunoassay throughout one year in 10 sheep maintained indoors under natural light and consuming a constant amount of feed. Plasma T4 concentrations varied throughout the year, the highest and lowest values occurring in the spring and autumn months respectively. The mean of all observations was 5 ·4±0·1 ,ug/dl. The changes observed did not appear to correlate with changes in ambient temperature, day length or with reported changes in wool growth.

Topic: Meat and Animal Product Quality
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Industrial power system automation: Synergistic benefits of integrating protection, instrumentation and control

Advances in microprocessor technology have resulted in greater performance at decreasing cost. This technology is being successfully applied to protection, instrumentation, and control of industrial power systems. Integrating these functions through data communications results in a synergism, such that the collective benefits exceed those which are achievable individually. The authors explore the various ways in which industrial power users may benefit through reduced energy costs, more efficient utilization of power distribution equipment, and improved power system reliability. It is anticipated that users will use these examples as catalysts for discovering additional innovative applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Smart Grid Security and Resilience
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Correlation between CT Number shift and tissue temperature change during radiofrequency ablation: an ex-vivo study using bovine liver

Abstract Current post-RFA (radiofrequency ablation) evaluation of unresectable liver tumours relies on visual inspection of non-enhancing tissues on the contrasted CT (computed tomography) images. This research investigated the correlation between CT number shift (dHU) and tissue temperature change (dT) during real-time CT-guided RFA of ex-vivo bovine livers. The study aimed to develop a non-invasive CT thermometry method to guide clinicians in assessing ablation outcome. 10 liver samples were individually ablated for 12 minutes using a RFA electrode, powered by an impedance-controlled RF generator (Cool-tipTM, Metronic, USA) and subsequently cooled for 15 minutes. An optical fiber inscribed with 4 equally spaced Fiber Bragg Gratings (FBG) was inserted sideward through the liver to measure 4 temperature points at the grating positions. CT scans were performed at interval of 3 minutes from 0 to 27 minute. CT numbers at the grating positions were manually extracted, and dHU and dT were computed and plotted to investigate the relationship. From the results, CT number decreased as temperature increased during RFA, and vice versa. A negative linear relationship (y = -0.66x + 1.23, R 2 = 0.925) between dHU and dT was observed. The thermal sensitivity was determined as -0.66 ± 0.03 HU/˚C. The strong correlation between dHU and dT during RFA could be used to estimate tissue temperature based on the CT number measured during real time CT-guided RFA. This approach would help the interventionalists in determining the ablation outcome hence improving treatment efficacy.

Topic: Ultrasound and Hyperthermia Applications
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Transparency, Documentation, and Open Science

Abstract Some GSA journals are especially interested in promoting transparency and open science practices, reflecting how some subdisciplines in aging are moving toward open science practices faster than others. In this talk, I will consider the transparency and open science practices that seem most relevant to aging researchers, such as preregistration, open data, open materials and code, sample size justification and analytic tools for considering null effects. I will also discuss potential challenges to implementing these practices as well as reasons why it is important to do so despite these challenges. The focus will be on pragmatic suggestions for researchers planning and conducting studies now that they hope to publish later.

Topic: Meta-analysis and systematic reviews
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
21st-Century Genetics in Psychiatric Residency Training

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal

Topic: BRCA gene mutations in cancer
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SHCBP1 Promotes the Progression of Esophageal Squamous Cell Carcinoma Via the TGFβ Pathway

Esophageal cancer (EC) is known as a type of common malignant tumor, with the incidence ranking eighth worldwide. Because of the high metastasis of advanced EC, the total survival rate has been quite low. Esophageal squamous cell carcinoma (ESCC) is a main type of EC. Targeted therapy for ESCC has become a new direction; however, newly therapeutic targets are also badly needed. Shc SH2 domain-binding protein (SHCBP1) is located on 16q11.2, which is a downstream protein of the Shc adaptor. SHCBP1 participates in the regulation of several physiological and pathologic processes, such as cytokinesis. Recent studies have found that SHCBP1 was abnormally upregulated in multiple types of tumors, such as breast cancer and liver cancer, and that it affects the proliferation and motility of cancer cells in vitro. However, it remains unclear whether SHCBP1 is related to the progression of EC. Herein, we found the upregulation of SHCBP1 in human EC tissues. Our findings further demonstrated that SHCBP1 expression was related to the clinical features of ESCC patients. We found that SHCBP1 depletion inhibited the proliferation and motility of ESCC cells via the transforming growth factor β pathway and that it suppressed the growth of tumors in mice. We, therefore, concluded that SHCBP1 could serve as a promising EC molecular target.

Topic: Cancer-related gene regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Value Chain Analysis: an ECR tool for assessing business competitive advantage

The goal of Value Chain Analysis (VCA), as a strategic tool, is to facilitate and speed up the application of Efficient Consumer Response (ECR) principles and methods. VCA methodology is applied keeping in mind the trends of a new era in the relationship between suppliers-producers-wholesalers and retailers. VCA approaches define current costs and performance, and assess the potential impact of proposed ECR improvement concepts across the entire supply chain. In this paper, the basic VCA approaches are described and compared with each other.

Topic: Quality and Supply Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Treatment of Cutaneous T-cell Lymphomas

Cutaneous T-cell lymphomas (CTCLs) are a diverse group of non-Hodgkin's lymphomas presenting as skin lesions containing malignant, skin-homing T cells. Mycosis fungoides (MF) and the leukemic variant, Sézary Syndrome (SS), are the most common CTCLs and the main focus of this chapter. Skin-directed therapy is sufficient for early patch/plaque MF which may remain indolent for many years. Biological response modifiers and phototherapy are added for SS, and for refractory or progressive MF. Experimental agents that block key pathways and targeted therapies are under development and will provide more options.

Topic: Cutaneous lymphoproliferative disorders research
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
The Effect of Direct Instruction on Spanish Language Acquisition in a Preschool Free-Play Environment: A Single-Case Design

The predicted increase in Spanish speakers within the United States brings to light a new direction for preschool curricula. There are multiple, on-going arguments about the best time for children to learn a second language and what role critical periods for brain development play in second language acquisition. Although there are individual differences in development, the current study demonstrates that children can learn Spanish vocabulary words with an average of 30 minutes of instruction per week. Using a combination of direct instruction with developmentally appropriate practices, hands-on, and engaging activities, the teaching of Spanish vocabulary, themed and age appropriate for preschoolers, was incorporated into the West Virginia University Nursery School classroom. Six children from the afternoon collaborative class were chosen to participate in various forms of activities that incorporated English and Spanish into play-based interactions. Using prompts and feedback or praise, the progress of the children across days and over weeks was recorded and examined. Girls improved significantly on Spanish words correctly identified from pre-test to post-test, while boys showed little to no improvement. However, all children improved in fluency, or time taken to identify a pictorial response. Across the five-week intervention, all children demonstrated improved pronunciation and increasing independence and use within each set of themed words. A combination of direct instruction and engaging, interactive activities was shown to be beneficial in the learning of the children. This method of teaching can be easily incorporated into a more naturalistic classroom setting by providing opportunities of various types to slip vocabulary, directives, and bilingual instruction into the daily routine.

Topic: Child Development and Digital Technology
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Isolation and Characterization of Xylanase-producing Paenibacillus sp. HY-8 from Moechotypa diphysis

Xylan이 풍부한 식물체를 먹이로 하는 하늘소의 장내에 존재하는 xylanase 생산 미생물의 탐색 과정에서 털두꺼비하늘소 (Moechotypa diphysis) 성충의 장으로부터 우수한 xylanase 생산균주 Paenibacillus sp. HY-8을 분리하였다. 생화학적, 계통학적 분석결과를 바탕으로 이 분리균은 Paenibacillus 속에 속하는 종으로 분석되었다. HY-8 균주에서 xylanase 생산은 제한배지에 xylan을 첨가함으로써 유도되는 특성을 나타내었고 1% 의 yeast extract와 0.5%의 birchwood xylan이 포함된 M9 배지에서 <TEX>$25^{\circ}C$</TEX>, 24시간의 배양에 의해 xylanase의 생산이 최대치에 도달하였다. HY-8 균주가 생산하는 xylanase는 pH6.0에서 여러 가지 식물성 사료의 원료에 대하여 대조구로 사용된 Tricoderma sp. 유래의 xylanase에 비해 우수한 분해능을 나타내었다. From the course of screening of useful xylanase producing microorganism from a phytophagous longicorn beetle, we isolated an extra-cellular xylanase producing strain, Paenibacillus sp. HY-8 from the intestine of Moechotypa diphysis adult. On the basis of morphological, biochemical and phylogenetic studies of the new isolate was identified as a Paenibacillus species. Production of xylanase in this strain was strongly induced by adding xylan to the growth medium and repressed by glucose or xylose. The highest xylanase production was attained in the M9 media containing 1% yeast extract and 0.5% birchwood xylan when cultured at <TEX>$25^{\circ}C$</TEX> for 24 hrs. HY-8 producing xylanase showed superior hydrolytic activities against various plant source feedstuff than control xylanase produced by Tricoderma sp. at pH 6.0.

Topic: Studies on Chitinases and Chitosanases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Why Experimental Vasospasm Resolves

P112 It has been suggested that changes in the arterial wall contribute to the maintenance and resolution of vasospasm after subarachnoid hemorrhage (SAH). This study determined if such changes contribute to the resolution of vasosapsm after SAH, if vasospasm resolves because of loss of subarachnoid blood clot or if a combination of these mechanisms is involved. 27 monkeys underwent baseline angiography and unilateral (n = 17) or bilateral (n = 8) SAH. Animals with bilateral SAH underwent angiography 1, 3, 5 and 7 days later followed by euthanasia. Animals with unilateral SAH had angiography 7 days later. The clot then was removed in these animals and replaced with fresh clot (n = 7) or removed and not replaced (n = 5). The removed clot was placed on the left side (n = 12). Controls did not have clot removal (n = 5) and/or had fresh clot placed on the left on day 7 (n = 5). Angiography was repeated every 2 days until euthanasia on day 14. SAH caused significant middle cerebral artery vasospasm on day 7 that slowly resolved by day 14. Removal of clot on day 7 resulted in more rapid reversal of vasospasm suggesting that vasospasm depended on continued presence of subarachnoid clot rather than on or in addition to structural changes in the artery. Placing fresh clot on the right side on day 7 produced vasospasm that persisted without resolving suggesting that there is no preconditioning response in the artery that prevents or conributes to reversal of vasospasm. On the other hand, placing 7-day-old clot from the right onto the left caused significantly more rapid onset of severe vasospasm than placing fresh clot from animals 7 days after SAH, suggesting that breaking up the clot to replace it on the left increases release of spasmogens or that there is a negative adaptive response that exacerbates vasospasm. In conclusion, vasospasm resolves because of loss of subarachnoid clot. There is no evidence for a preconditioning response in cerebral arteries that renders them less responsive to subarachnoid clot. Spasmogen release from clot 7 days after SAH may be reduced in this model so that breaking up the clot increases spasmogen release resulting in rapid onset of severe vasospasm and/or that there is a negative adaptive response 7 days after SAH that worsens vasospasm.

Topic: Intracranial Aneurysms: Treatment and Complications
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
The myth of satrio piningit and the hope of Javanese society (philosophical hermeneutics analysis)

The way we look at something certainly is different with others. This is a common thing, because each of human being has been granted various particularity in understanding himself, others and even matter. Referring to the existence of human being himself, he himself is not but a part of the life, therefore can be said that actually human being is creature that is always limited in space and time, clearly creature that cannot be separated from space and time.&#13;\n\tThis can be seen from history, all activities of life begun from birth to his death. The embodiment of the history is a tradition. A thing that is hereditary given to us to keep and preserve it. If compared with Javanese world. This has the self meaning. Tradition brings us present. If understood deeply, tradition always want to reveal what it has, for what it feel and be always oriented to the future. One of the proof is a text.&#13;\n\tTo understand what is in a text, except is by interpreting, it is what called by interpretation. Thus what is existing in it can be revealed and certainly has relevance with the present.&#13;\nIf related to Satrio Piningit, he is a hidden heritage that comes from the Javanese ancestor. In it lies a inward state of Javanese society that makes various philosophical view that want to be said to a leader in leading the people. So it has the self relevance, which is new point of view in revealing various phenomenon in today’s leadership.

Topic: Cultural and Religious Practices in Indonesia
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
PSIII-14 Cotton gin byproduct in growing diets for beef steers

Abstract The purpose of this study was to evaluate the performance of beef cattle during the stocker phase when fed different concentrations of cotton gin byproduct (CGB). Angus steers [n = 50; initial body weight (BW) = 349 ± 66 kg) were stratified by BW and grouped in slatted floor pens (10 steers/pen). Steers were assigned randomly within pen (2 per pen) to one of five diets containing 0, 10, 20, 30, and 40% CGB (dry matter basis). Diets were balanced for protein and energy, and the steers were fed for 84 d. Steers were weighed on d -1, 0, 28, 56, 83, and 84 for the stocker phase with d -1 and 0, 83 and 84 averaged to give start and end BW. Following the growing period, steers were switched to the same finishing diet and fed for an additional 55 d prior to being transported to PA for harvest and carcass data collection. Data were analyzed using procMIXED of SASv9.4 to determine the significance of linear, quadratic, cubic, and quartic trends. During the growing phase, dry matter intake increased linearly (P = 0.0017) with 10.16, 11.23, 11.59, 11.86, and 11.96 kg/d for 0, 10, 20, 30, and 40% CGB, respectively. Average daily gain tended to increase (P = 0.0631) with a cubic trend, increasing with the first addition of CGB, declining at the intermediate levels, and then increasing again at the 40% level (1.34, 1.54, 1.36, 1.39, and 1.52 kg/d for 0, 10, 20, 30, and 40% CGB, respectively). Feed efficiency showed a similar cubic trend (P = 0.10) with 0.133, 0.138, 0.119, 0.117, and 0.128 for 0, 10, 20, 30, and 40% CGB, respectively. Within the finishing phase, average daily gain was significant (P = 0.026) as a quadratic trend with 1.54, 1.25, 1.18, 1.20, and 1.33 kg/d for 0, 10, 20, 30, and 40% CGB, respectively. Diets did not differ (P &amp;gt; 0.10) for dry matter intake (10.08 kg/d), feed conversion (8.31), or feed efficiency (0.130). Treatment did not influence (P &amp;gt; 0.10) marbling or other carcass measurements. Data suggest CGB supported good animal gains with only minor impact on feed intake and feed efficiency for stocker steers up to an inclusion rate of 40%.

Topic: Agriculture and Rural Development Research
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences