jimnoneill/paper-to-field-training huggingface dataset:
Comparative characterization of UDP‐glucuronic acid (UDP‐GlcUA) binding‐site directed inhibitors with human UGT2B7 and 1A10.

Recent crystallography, homology modeling, and mutagenesis studies of human UGTs have demonstrated that UGT2B7 and 1A10 possess a number of distinctive UDP‐glucuronic acid contact amino acids. We have investigated the specificity of these co‐factor binding sites further using 8 bi‐dentate inhibitors containing a lipophilic and a uridine moiety. K i and IC 50 values were calculated for PP55B and inhibition types were determined. Models of the UGT1A10 UDP‐GlcUA binding site were built using the crystal structure of the UGT2B7 C‐terminal domain as a template and using sequence homology to available structures of plant glucosyltransferases with the GT‐B folding motif. We have detected potential differences in the tertiary structure/function of the C‐terminal domain of these two isoforms and subsequently docked PP55B at the UDP‐GlcUA binding site in order to model inhibitor complexes for each enzyme, including its possible location with respect to the N‐terminal domain. Establishing the roles of individual UGT isoforms is important for UGT‐based drug discovery. The goal of theses studies is aimed at the identification of potent, selective UGT inhibitors, which could help to define these roles and provide the basis for the design of therapeutic agents. NIH‐DK60109, GM075893 (AR‐P)

Topic: Glycosylation and Glycoproteins Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Finger blood pressure and rewarming rate for screening and diagnosis of Raynaud's phenomenon in workers exposed to vibration.

Both the finger systolic blood pressure (FSP) and the rewarming test of finger skin are measures of circulation in the finger; the first reflects the vasoconstriction phase and the second the vasodilatation phase. The combinations of the specificity and the sensitivity of these methods were evaluated by a receiver operating characteristic curve (ROC). The material included 37 vibration-induced white finger (VWF) cases, five primary Raynaud's cases, and 37 controls. The specificity of the FSP test was high with regard to the anamnesis of white finger and the test was useful for the diagnosis of Raynaud's phenomenon, but the sensitivity was too low for screening. The rewarming test was useful for screening primary Raynaud's case and possibly for screening disorders in peripheral vasodilative function. The connections between the rewarming test and VWF are not clear and according to the present study the rewarming test was not suitable for screening VWF.

Topic: Effects of Vibration on Health
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
The role of contests and talent shows as part of the artist development process within the music industry

Providing an opportunity for getting instant exposure and building a large fan base, contests and talent shows have often been considered by young artists as a potential shortcut to a successful music career. Addressing the potential gap in research, this chapter aims to define the role of live contests and talent shows in today's music industry, both as a stage of the artist development process, and as a potential form of business, through the perspectives of both music artists and entrepreneurs. The research has a very specific, and quite unusual, multifaceted nature, which combines topics related to both the artists' perspectives on talent development, and the entrepreneurs' motivation as contest organisers – including the profitability of these projects – which is considered the business aspect most relevant to the aim of the study. Therefore, a well-developed strategy is required in terms of the study's design and methodology, and the appropriate choice of specific methods to be used.

Topic: Cultural Industries and Urban Development
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
STRUCTURE-ACTIVITY RELATIONSHIPS OF A SMALL MOLECULE INHIBITOR OF AMINOGLYCOSIDE 6'-N ACETYLTRANSFERASE TYPE Ib [AAC(6')-Ib]

Aminoglycosides are a standard treatment for gram-negative bacterial infections but, their efficacy is declining due to the rise and dissemination of antimicrobial resistance. Resistance to aminoglycosides is caused mainly by aminoglycoside modifying enzymes, with aminoglycoside (6’)-N-acetyltransferase type Ib [AAC(6')-Ib] being the most clinically relevant in Gram-negative pathogens. This enzyme catalyzes the inactivation of aminoglycosides by transferring an acetyl group from acetyl CoA to the 6’ amino group of the antibiotic molecule. A strategy to combat this issue is the development of inhibitors of AAC(6’)-Ib. Using mixture-based combinatorial libraries, the scaffold ranking approach and the positional scanning strategy, inhibitors were searched for and identified. A compound was identified and found to be potent against AAC(6')-Ib, potentiated the activity of amikacin against three resistant bacteria-harboring aac(6')-Ib and improved the survival of Galleria mellonella infected with Klebsiella pneumoniae and Acinetobacter baumannii strains harboring aac(6’)-Ib. To further develop this potential inhibitor, the structure-activity relationship approach was applied to a series of experiments involving analog of this inhibitor at five R diversity positions of the compound and were tested for the ability to inhibit AAC(6’)-Ib in vitro and to potentiate the antimicrobial action of amikacin against an Acinetobacter baumannii strain harboring aac(6’)-Ib. Most changes were found to either diminish or have negligible effects on the performance of the inhibitor, except at R5 diversity position which didn’t result in a significant reduction in performance. In addition, compound 19 exhibited antimicrobial properties that may warrant further investigation. In the end, a better understanding of the inhibitor was achieved; however, more work is needed for the continued development of this compound.

Topic: Carbohydrate Chemistry and Synthesis
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
On the application of a Krylov subspace spectral method to poroacoustic shocks in inhomogeneous gases

Abstract Poroacoustic shocks in inhomogeneous gases are numerically simulated using Krylov subspace spectral (KSS) methods; specifically, existing KSS methods are modified to use basis functions tailored to the assumed density profile of the gas, and to handle the nonhomogeneous boundary condition used to insert the shock‐inducing signal. The simulations presented demonstrate that KSS methods are effective at capturing the features of the solution, consistent with theoretical expectations, even when using a time step that greatly exceeds the CFL limit.

Topic: Seismic Imaging and Inversion Techniques
Subfield: Geophysics
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Differential Transformation Method And Variation Iteration Method For Cauchy Reaction-diffusion Problems

The paper reads the flow of an incompressible, unidirectional, steady third grade non-Newtonian fluid between two infinite planes.The flow is symmetric with respect to xaxis with constant pressure gradient.The governing equations for the flow are second order nonlinear differential equations.Homotopy Analysis Method is applied to obtain the solution.

Topic: Fractional Differential Equations Solutions
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
A local LDA based method for Latent Aspect Rating Analysis on reviews

The expanding volume of online reviews has made it an important and challenging task to mine detailed information of opinions in those reviews. In many cases, along with the comment, a user also gives an overall rating on the target entity, which in fact could not reflect the detailed opinions on each aspect of the entity. Therefore, Latent Aspect Rating Analysis (LARA) came into being. The goal of LARA is to infer a latent rating and weight for each aspect based on the overall rating and the review content. Although some methods have been applied to solve this problem, they rely too much on the predefinition of aspects with keywords, which needs supervision and may hence introduce some biases. In this paper, we propose a Local LDA based method for LARA, which includes two stages. In the first stage, we employ Local LDA to discover aspects automatically. In the second stage, we use LRR model to infer the latent rating and weight for each of the discovered aspects. The experimental results on the review dataset demonstrate the advantages of the proposed method over the state-of-the-art methods.

Topic: Sentiment Analysis and Opinion Mining
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Power Spectrum Based Representation of Vortex Flowmeter Signal Energy and Its Application

In order to investigate the energy distribution of the actual vortex signal from vortex flowmeter,a new approach for representing the vortex flowmeter signal energy was put forward based on the amplitude of power spectral density.The power-spectrum energy ratio(PSER) of vortex signal was proposed and defined,which was used to quantitatively study the energy relationship between the actual flowrate signal and the total output signal of the vortex flowmeter.The results show that the PSER in this study scattered in a wide range of percentage.The PSER values of water and air measurement were within 38%～96% and 10%～65% respectively.Moreover,the PSER in the signal obtained at a closer position to the bluff body,where the vortex signal was strong and easy for detection,was greater than those at farther positions.Therefore,the PSER of vortex signal could be adopted as a parameter for directing how to select the sensor location in vortex flowmeter optimally.

Topic: Flow Measurement and Analysis
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Lycopsis variegata Linnaeus, 1753, spec. nov.

Lycopsis variegata, spec. nov. 2. Lycopsis foliis repandis dentatis callosis, caule decumbente, corollis cernuis. Hort. ups.34. Lycopsis foliis repando-dentatis. Hort. cliff. 44. Roy. lugdb. 404. Buglossum creticum verrucosum. Stiss. bot. 57. t.57. Buglossum annuum humile, bullatis foliis, flore caeruleo eleganter variegato. Moris. hist. 3. p.439. s.11. t.26. f.10. Habitat in Creta . ☉

Topic: Mediterranean and Iberian flora and fauna
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
<scp>P08</scp>.04: Fetal umbilical artery Doppler velocimetry studies versus <scp>CTG</scp> monitoring as predictors of adverse perinatal outcome in <scp>IUGR</scp> fetuses: a retrospective study

A study done on 40 patients with IUGR admitted at the IMU, MFM Section, University of the Philippines-Philippine General Hospital from January-July 2008 compared the efficacy of Dopplers vs CTG in predicting adverse fetal outcome. Doppler and CTG results within 1 week from delivery were considered.Lead time was calculated by determining the time interval(days)from the first abnormal Doppler and the development of an abnormal CTG result.The perinatal outcome parameters were AOG on delivery, indication for termination, mode of delivery, BW, length of stay at the NICU, APGAR score < 7 and mortality. There were 23 abnormal CTG and 12 abnormal Doppler results, 6 neonatal deaths and 1 antepartal death. Most perinatal deaths occurred in the group were both tests were abnormal. Lead time was 4 days. Both umbilical artery Doppler studies and CTG are useful predictors of adverse perinatal outcome; however Doppler studies is a better predictor as it recognizes fetal compromise earlier than CTG.Once an abnormal CTG result occurs following an abnormal umbilical Doppler, the worst perinatal outcome is anticipated. In IUGR fetuses wherein pulmonary maturity is already established, it is better to deliver before the CTG becomes abnormal.

Topic: Renal and Vascular Pathologies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
The cytoskeleton and proliferation of melanoma cells under hyperthermal conditions. A correlative double immunolabelling study.

Hyperthermia provides a potent therapeutical tool of cancer treatment, the cell biological effects of which are fairly understood. In the present study we applied hyperthermal shocks of 42 degrees C and 44 degrees C to human melanoma cells under tissue culture conditions. The integrity of the microtubular (mT) system and rate of DNA replication was assessed by indirect immunofluorescence using antibodies to tubulin as an mT marker and to BrdU as an indicator for DNA replication. Through this approach we obtained evidence that heat (44 degrees C for 60 min) exerts a profound damaging effect on the mT system accompanied by a change in the phenotypical appearance of melanoma cells. DNA replication, however, was still in progress in a significant number of heavily afflicted cells. From these data we conclude that a therapeutic regiment combining hyperthermia and mT inhibitors might prove useful in the treatment of human melanomas.

Topic: RNA Interference and Gene Delivery
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
LHD SXmp #49961.1

Soft X-ray detector array system measures the radial soft X-ray emission profile from LHD for equilibrium and stability analysis by using multi-channel scintillator. Soft X-ray is converted to visible light and detected by PMT. Frequency up to 200kHz can be covered.

Topic: Death Anxiety and Social Exclusion
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
PENGARUH UKURAN POLYBAG TERHADAP PERTUMBUHAN VEGETATIF SAWI PAKCOY (BRASSICA RAPA L.)

Horticultural crops are very popular plants. One of the leading horticultural products in the agricultural sector in Indonesia is vegetable crops. Green mustard pakcoy (Brassica rapa L.) is a vegetable plant that is very easy to breed in cold and hot areas, at an altitude of 500 m to 1200 m above sea level. Limited land for planting mustard pakcoy (Brassica rapa L.), for daily needs can be planted in polybags. The size of the polybag used needs to be considered. The experiment was carried out in a green house at KWT Jeruk Manis on Jl Dukuh Saleh Pejeruk Ampenan. The variables observed included: average plant height, average number of leaves, average leaf width and fresh plant weight. The measurement data were analyzed using analysis of variance (CRD) and DMRT further test. From the results of the analysis, the experimental results showed that the size of a small polybag 15 x 20 cm had a significant effect on the observed variables, namely plant height (cm), number of leaves (strands), leaf width, and mustard greens

Topic: Plant Growth and Agriculture Techniques
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
“Decoupling” Indicators for Evaluation of Urban Low-Carbon Economy Development: a Case Study of Shanghai

Environment are closely related to energy and they are two of the most important issues this century. So the development of a low-carbon economy and the construction of environment friendly society are the only way for the further development of China its own. In this study, "decoupling" indicators for evaluation of a low-carbon economy development are proposed. "Decoupling" indicators of energy consumption and economic growth were selected to reflect the response relationship between economic growth and the changes of resources, including weak, strong and expansive/recessive degree of decoupling. Similarly, "decoupling" indicators of carbon dioxide emissions and economic growth were chosen to reflect the response relationship between economic growth and the changes of environment. Shanghai, in the Eastern China, was selected as a special case. The results showed a change from expansive negative coupling to week decoupling regarding both of energy consumption and carbon emissions in Shanghai during the period 1991-2013, indicating that we have achieved some significant outcome in the process of the low-carbon economy development in Shanghai. However, in view of the possibility of expansive negative coupling, we should continue to make efforts for the development of the low-carbon economy.

Topic: Energy, Environment, Economic Growth
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Mycobacterium chelonae Scleral Abscess After Intravitreal Ranibizumab Injection

Injection-site scleral abscesses are very rare and serious complications of intravitreal injections. Once the abscess is drained, it is possible to identify the organism and treat the infection with appropriate combination antibiotic therapy.

Topic: Mycobacterium research and diagnosis
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Banana peduncle: to waste or not to waste?

Banana peduncle from Musa cavendishii was studied for its components and utilization into high value added products. Fiber and juice were found to be the main components and these were extracted by means of retting and by mechanical press, respectively. The cell length of peduncle fiber is longer than those from other non-wood materials and classifies it as a long fiber. The tensile strength of the inner fiber (5.18 kg f/gm) is comparable to water lily fiber. Peduncle fiber has high holocellulose content (approximately 75.0%), alpha cellulose (51.72-58.90%) and hemicelluloses (15.92-16.77%). Peduncle juice was found to be 80% by fresh weight, has high total Polyphenol content (342.89 micro g GAE/mL) and high contents of potassium (425.80 mg/100 mL) and sodium (455.20 mg/100 mL). Peduncle juice showed no adverse effects in acute oral toxicity tests in mice. Dried fiber was utilized for dietary fiber enrichment of meat products, in addition to some identified functional properties, for manufacture of fiber boards, for pulp and paper, for micro cellulose production and for compost. The juice was added to ready-to-drink calamansi for potassium ion and Polyphenol fortification, used as potassium supplement in hydroponics of various salad greens, as liquid potassium fertilizer for banana and other high value crops. Based on the limited fertilization experiments, peduncle juice plus a nitrogen source like urea gives more biomass and higher marketable yield. From all these results, banana peduncle should not be left to waste. The various products shown to be derived from this material can supplement income of farmers and create new enterprises using simple technologies.

Topic: Banana Cultivation and Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
β-Sitosterol Inhibits Tumor Growth and Amplifies Rituximab Sensitivity through Acid Sphingomyelinase/Ceramide Signaling in Diffuse Large B-Cell Lymphoma

Rituximab (RTX) resistance is a notable challenge in treating diffuse large B-cell lymphoma (DLBCL). β-Sitosterol (β-ST) is a plant sterol that has been found in a broad variety of fruits, spices, and medicinal plants. The antineoplastic properties of β-ST are established in various solid malignancies; however, its effect on DLBCL is uncharted. This study investigates the role of β-ST in DLBCL as well as the underlying mechanisms. Our findings indicated that β-ST impeded DLBCL cell proliferation in a concentration- and time-dependent manner. β-ST appeared to alter sphingolipid metabolism, facilitate acid sphingomyelinase (ASM) translocation to the plasma membrane, augment ceramide platforms through increased ceramide synthesis, and consequently induce apoptosis in DLBCL cells. Furthermore, we found that RTX initiated both apoptotic and survival pathways <i>in vitro</i>, with the former contingent on the transient activation of the ASM, and β-ST could amplify the anti-DLBCL efficacy of RTX by modulating ASM/Ceramide (Cer) signaling. Collectively, our findings elucidate the mechanistic role of β-ST in DLBCL and underscore its potential in amplifying the antineoplastic efficacy of RTX via ASM activation, proposing a potential avenue to improve the efficacy of RTX therapy.

Topic: Sphingolipid Metabolism and Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Increasing Learning Outcomes through the Student Team Heroic Leadership and Provision of Structured Tasks Strategies

Learning in schools is not only intended to achieve educational goals for certain lessons but also to equip students to master the concept of material and apply it in everyday life. Moreover, learning is also intended to achieve educational goals as a whole general which is formal, namely, to organize students' reasoning and shape their personalities. This research is classroom action research that aims to improve learning outcomes through student team heroic leadership strategies and the provision of structured assignments. The subjects in this study were students of class X.2 MA DDI Kaballangang, Pinrang. This research is Classroom action research carried out in two cycles. Data collection using learning outcomes tests sheets and observation sheets. The collected data is analyzed using quantitative analysis techniques and qualitative analysis, presenting information, and drawing conclusions. The results showed that there was an increasing learning outcome through student team heroic leadership strategies and the provision of structured assignments which was marked by an increase in the average score of student learning outcomes from cycle 1 to cycle 2, which was 61.28 increasing to 83.72, student learning completeness in the second cycle. I which has not been achieved classically only reached 48.3%, but in cycle 2, classical completeness was achieved, namely 89.7% so there was an increase in the percentage of student activity in the learning process from cycle 1, namely 35.28% to cycle 2, namely 47.32%

Topic: Educational Methods and Outcomes
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

Anionic phospholipids are critical constituents of the inner leaflet of the plasma membrane, ensuring appropriate membrane topology of transmembrane proteins. Additionally, in eukaryotes, the negatively charged phosphoinositides serve as key signals not only through their hydrolysis products but also through direct control of transmembrane protein function. Direct phosphoinositide control of the activity of ion channels and transporters has been the most convincing case of the critical importance of phospholipid-protein interactions in the functional control of membrane proteins. Furthermore, second messengers, such as [Ca 2+ ] i , or posttranslational modifications, such as phosphorylation, can directly or allosterically fine-tune phospholipid-protein interactions and modulate activity. Recent advances in structure determination of membrane proteins have allowed investigators to obtain complexes of ion channels with phosphoinositides and to use computational and experimental approaches to probe the dynamic mechanisms by which lipid-protein interactions control active and inactive protein states.

Topic: Lipid Membrane Structure and Behavior
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences