jimnoneill/paper-to-field-training huggingface dataset:
Second-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRs

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTSecond-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRsAhmed F. Abdel-Magid*Ahmed F. Abdel-MagidTherachem Research Medilab, LLC. 100 Jade Park, Chelsea, Alabama 35043, United States*E-mail: [email protected]More by Ahmed F. Abdel-MagidCite this: ACS Med. Chem. Lett. 2019, 10, 10, 1374–1375Publication Date (Web):September 26, 2019Publication History Received18 September 2019Published online26 September 2019Published inissue 10 October 2019https://doi.org/10.1021/acsmedchemlett.9b00427Copyright © 2019 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2038Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (504 KB) Get e-AlertsSUBJECTS:Assays,Cancer,Genetics,Inhibitors,Peptides and proteins Get e-Alerts

Topic: Fibroblast Growth Factor Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Game of Heritage: Enhancing Virtual Museum Visits Through Gamification for Tourists

This study delves into the integration of gamification within virtual museum experiences, focusing on its effects on visitor engagement and knowledge acquisition. In today's digital cultural heritage landscape, virtual museums emerge as innovative platforms for the dissemination of educational and cultural content. This research specifically assesses the impact of gamified elements namely points, badges, and leaderboards on enhancing the visitor experience in a virtual environment dedicated to the Himmapan creatures, a crucial aspect of Thai mythology exhibited at the Roitawarabarn Baandhawalai Museum in Chiang Mai, Thailand. Utilizing a quantitative methodology that includes the user engagement scale and a knowledge acquisition questionnaire, this study compares visitor interactions between gamified and non-gamified approach of the virtual museum. The findings reveal that gamification substantially enhances visitor engagement, especially in aspects such as focused attention and rewards, and significantly boosts knowledge acquisition when compared to non-gamified experiences. These outcomes emphasize the crucial importance of integrating gamification strategies within virtual museums to cultivate an experience that is interactive, engaging, and educational for visitors.

Topic: Educational Games and Gamification
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Clinical characteristics and evolution of hematological patients and COVID-19 in Argentina: a report from the Argentine Society of Hematology.

Individuals with malignancies and COVID-19 have a lower survival compared with the general population. However, the information about the impact of COVID-19 on the whole hematological population is scarce. We aimed to describe the 30th day overall survival (OS) after COVID-19 infection in patients with a hematological disease in Argentina. A completely anonymous survey from the Argentine Society of Hematology was delivered to all the hematologists in Argentina; it started in April 2020. A cut-off to analyze the data was performed in December 2020 and, finally, 419 patients were reported and suitable for the analysis (average age: 58 years, 90% with malignant diseases). After the COVID-19 diagnosis, the 30-day OS for the whole population was 80.2%. From the entire group (419), 101 (24.1%) individuals required intensive care unit admission, where the 30-day OS was 46.6%. Among allogeneic stem cell transplant recipients, the 30-day OS was 70.3%. Factors associated with a low OS were two or more comorbidities, an active hematological disease and history of chemotherapy. In individuals with the three factors, the 30-day OS was 49.6% while the 30-day OS in those without those factors was 100%. Patients with hematological diseases have a higher mortality than the general population. This group represents a challenge and requires careful decision-making of the treatment in order not to compromise the chances of cure.

Topic: COVID-19 and healthcare impacts
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The Drilling Method Application Using Abacus to Arithmetic Operations Skills in Student with Hearing Impairment at Special School

The purpose of this study was to determine the effect of the drilling method application using abacus in improving arithmetic subtraction operations skills in deaf children. This study used an experimental method with Single Subject Research (SSR), A-B-A design. The drilling method was used in the learning process. In addition, the abacus media was also used in the subtraction arithmetic operation material in learning mathematics. The results showed that there was an effect of applying the drilling method using abacus in improving the arithmetic subtraction operation skills in deaf children with the initials SS. This could be seen from the increase in the mean level of student’s abilities starting from baseline-1 (A1) by 30%, intervention (B) by 65%, and baseline-2 (A2) by 86.66%. The methods and media were suitable to make the lesson easier to understand for students. The drilling method with the abacus media could be used as an alternative for teachers in improving the skills of arithmetic subtraction operations in deaf children. The results of this study are expected to contribute to developing special education related to the application of the drilling method using abacus media to improve arithmetic operations skills in learning next math.

Topic: Child Development and Education
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
The unrealized project: the Moscow Kremlin as a museum city

The published document «The Adaptation’s Project of the Moscow Kremlin’s Building to a Museum city» has appeared on June, 17th, 1917 in the time of the Provisional government. This is the typewritten text publishing by means of a hectograph. Authors of the document — the outstanding Russian art workers: architect R. I. Klein, critic I. E. Grabar, collector E. F. Vishnevsky, professor of the Moscow State University P. Langovoj and architect-collector I. A. Kuznetsov. All of them were the part of the Commission of the protection of the Kremlin and the Moscow palaces and the takeover of palace property (March 1917 — spring of 1918) that existed at the Moscow municipal duma. The project had a unique large-scale character: it suggested to convert the Kremlin into the basic Moscow museum centre and to concentrate all available museum and private collections in the center. The knowledge of the condition of the Kremlin relics and monuments and the plan’s scrupulousness distinguished this Project. The project has not been discussed in a press, did not become public, however domestic historians remember it.

Topic: Archaeological Research and Protection
Subfield: Space and Planetary Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Comparison Of Selected Behavioural Patterns Of German Shepherd Puppies In Open-Field Test By Practical Assessment Report

Over the past 80 years, open-field method has evolved as a commonly used tool for the analysis of animal behaviour. The study was carried out using 50 kennel-reared purebred puppies of the German Shepherd dog breed. All dogs were tested in 5<sup>th</sup>, 7<sup>th</sup>, and 9<sup>th </sup>week of age. For the purpose of behavioural analysis, an open-field evaluation report was designed prior to testing to ensure the most convenient, rapid, and suitable way to assess selected behavioural patterns in field conditions. Onset of vocalisation, intensity of vocalisation, level of physical activity, response to sound, and overall behaviour was monitored in the study. Correlations between measures of height, weight and chest circumference, and behavioural characteristics in the 5<sup>th</sup>, 7<sup>th</sup>, and 9<sup>th</sup> week of age were not statistically significant. Onset of vocalisation, intensity of vocalisation, level of physical activity and response to sound differed on statistically significant level between 5<sup>th</sup>, 7<sup>th</sup>, and 9<sup>th</sup> week of age. Results suggest that our practical assessment report may be used as an applicable method to evaluate the suitability of service dog puppies for future working roles.

Topic: Meat and Animal Product Quality
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
A qualitative rockfall hazard screening tool for open pit mining

Rockfall is a key focus for geotechnical risk management and operational safety in the current mining environment.Due to limited site records and variability in rockfall conditions and outcomes, risk assessments are ideally completed by experienced practitioners who can make sound judgement calls.The reality in an operational space is that these assessments are often undertaken by site staff that are junior or inexperienced.This may result in a site operating at a higher than acceptable risk level due to rockfall.The development of a qualitative rockfall hazard screening tool for a benched mine slope is outlined in this paper.It is intended to be quick and easy, providing a structured, repeatable framework to assess rockfall hazard.The tool acts as a guide to assist staff in making important judgement calls about rockfall hazard in the field.The tool utilises a rating system to assess factors contributing to the intensity and likelihood of a rockfall occurring.Intensity factors include block size, block weight, slope height and geometry, all of which influence possible impact energy.Likelihood factors include slope geometry features, accumulation of loose material and batter condition.All ratings have been calibrated to conditions at a case study site utilising field trials and extensive sensitivity rockfall modelling.Once all factors have been assessed in the field and office, the intensity and likelihood factor totals are compared to a hazard matrix which allocates a rockfall hazard level for that slope.Applications for this tool include routine slope hazard assessments in active working areas, providing semi-qualitative hazard information for risk assessments and generating rockfall hazard maps for communication to site staff.While this tool was developed for a specific case study site, it can be readily modified and calibrated for other sites.

Topic: Landslides and related hazards
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
Activation of the TRPV1 Thermoreceptor Induced by Modulated or Unmodulated 1800 MHz Radiofrequency Field Exposure

The existence of effects of radiofrequency field exposure at environmental levels on living tissues and organisms remains controversial, in particular regarding potential "nonthermal" effects produced in the absence of temperature elevation. Therefore, we investigated whether TRPV1, one of the most studied thermosensitive channels, can be activated by the heat produced by radiofrequency fields and by some specific nonthermal interaction with the fields. We have recently shown that TRPV1 activation can be assessed in real-time on live cells using the bioluminescence resonance energy transfer technique. Taking advantage of this innovative assay, we monitored TRPV1 thermal and chemical modes of activation under radiofrequency exposure at 1800 MHz using different signals (CW, GSM, UMTS, LTE, Wi-Fi and WiMAX) at specific absorption rates between 8 and 32 W/kg. We showed that, as expected, TRPV1 channels were activated by the heat produced by radiofrequency field exposure of transiently-transfected HEK293T cells, but found no evidence of TRPV1 activation in the absence of temperature elevation under radiofrequency field exposure. There was no evidence either that, at fixed temperature, radiofrequency exposure altered the maximal efficacy of the agonist Capsaicin to activate TRPV1.

Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Banking Union's accountability system in practice: A health check‐up to Europe's financial heart

Abstract The Single Supervisory Mechanism (SSM) and Single Resolution Mechanism (SRM) form the Banking Union, which comprises EU authorities (ECB and SRB) and national authorities (NCAs and NRAs) with vast powers. Although crucial for its legitimacy, the Banking Union’s accountability is flawed, and not for the (stereo)typical reasons: accountability is a visible concept in SSM and SRM regulations, and political, administrative and judicial bodies are knowledgeable, engaged and thorough. Rather, this article posits that the SSM and SRM work very well because the legislature focused on practical details such as information flows, planning and continuity and coordination, while there has been no comparable effort to ensure the functioning of accountability tools. The result is a “system” characterised by limited access to crucial information, lack of continuity, and uncoordinated functioning. Changing this should not be hard but requires replacing blanket criticism and stereotypical views with greater attention to detail.

Topic: Global Financial Regulation and Crises
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Fermentation Quality of Alfalfa and ltalian Ryegrass Silages Treated with Previously Fermented Juices Prepared from Both the Herbages

Two hundred grams of alfalfa (Medicago sativa L.) and Italian ryegrass (Lolium multiflorum Lam.) were macerated with 1l of water using a blender and filtered through cheese cloth. The filtrate was kept anaerobically for 2d with or without 2% sucrose (previously fermented juice; PFJ). Alfalfa PFJ with sucrose and Italian ryegrass PFJ without sucrose were used as silage additives. Both of them were added to alfalfa and Italian ryegrass prior to ensile at 2.5ml/kg as to inoculate 106/g of lactic acid bacteria (LAB). Alfalfa used at the present study was not necessary to add PFJ for enhancing the silage fermentation. But the fermentation quality of Italian ryegrass silage was improved by the addition of alfalfa or Italian ryegrass PFJ and Italian ryegrass PFJ was a little more effective than alfalfa PFJ, suggesting that PFJ from other plant is available but that from the same plant to be ensiled is more effective as silage additive.

Topic: Ruminant Nutrition and Digestive Physiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Alfalfa Weevil Control, 1987

Abstract The trial was conducted on 24 Apr near Cook Station, Mo., on a 1-yr-old stand of alfalfa. Plots were 20 × 40 ft and arranged in a randomized complete block design with 4 replications. The alfalfa was 15 inches tall at time of treatment. Temperature was 77°F, skies were cloudy, and winds were 0-3 mph. Sprays were applied with a 20-ft spray boom, 8002 flat-fan nozzles, and 50-mesh screens. Sprays were applied at 16.5 gal/acre and 20 psi. Measurable precipitation fell on 5 of the 28 days following treatment. Evaluations were conducted at 3, 7, 14, 21, and 28 days posttreatment by taking 10 180-degree sweeps with a 15-inch-diam sweep net. The data were transformed by × + 0.5 for analytical purposes, but actual means are presented in the table.

Topic: Plant and fungal interactions
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Atlas of Diagnostic Oncology

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal

Topic: BRCA gene mutations in cancer
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Conclusion

This chapter considers the new vision of democracy ushered in by the generation of the 1960s. Unlike the architects of the postwar order, left-wing students challenged, rather than celebrated, the legitimacy of elected institutions and party politics. Parliaments were merely stages for oligarchies, tools for self-perpetuating elites. In both West Germany and the United States, students claimed that state institutions inevitably reinforced rigid hierarchies and oppressive norms. A “true” democracy could not be built by state agencies. Rather, it would emerge from “autonomy,” from small organizations, student movements, NGOs, and, later, human rights organizations. When the frustration and anger of this new generation exploded in protest in the late 1960s, German émigrés were among its main targets. Student journals and pamphlets frequently attacked and ridiculed the leading thinkers of the older generation. Such criticism was especially ferocious in West Germany, where returning émigrés came to represent Cold War ties with an amoral and depraved United States.

Topic: Communism, Protests, Social Movements
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Potent Protective Effect Of &amp;#945 -Tocopherol And Fish Oil On In Vivo Paraquat Induced Oxidative Damage In Rats

The potential protective role of &#945-tocopherol and fish oil against oxidative damage induced by paraquat were investigated. Forty male albino rats with average body weight of 100-120 gm were housed in 8 groups of 5 rats each. The first group served as control and injected with saline, group 2 was injected with a single dose of paraquat (10 mg/kg, intraperittoneally) for 24 h prior to decapitation (P), group 3 was administered orally with vitamin E (100 mg/kg) five times a week (E), group 4 was administered orally with fish oil (20 mg/kg) five times a week (FO); group 5 received FO+E, groups 6, 7 and 8 were administrated with P+E, P+FO and P+E+FO respectively. The content of microsomal proteins, drug metabolizing enzymes and thiobarbituric acid reactive substances (TBARS) were determined in liver microsome after treatment. Vitamin E together with fish oil significantly decreased the content of cytochrome b5 (p

Topic: Paraquat toxicity studies and treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Neutrino spin oscillations in a magnetized Polish doughnut

Abstract We study the gravitational scattering of ultrarelativistic neutrinos off a rotating supermassive black hole (BH) surrounded by a thick magnetized accretion disk. Neutrinos interact electroweakly with background matter and with the magnetic field in the disk since neutrinos are supposed to possess nonzero magnetic moments. The interaction with external fields results in neutrino spin oscillations. We find that the toroidal magnetic field, inherent in the magnetized Polish doughnut, does not cause a significant spin-flip for any reasonable strengths of the toroidal component. The reduction of the observed neutrino flux, owing to neutrino spin oscillations, is predicted. A poloidal component of the magnetic field gives the main contribution to the modification of the observed flux. The neutrino interaction with matter, rotating with relativistic velocities, also changes the flux of neutrinos. We briefly discuss the idea of the neutrino tomography of magnetic field distributions in accretion disks near BHs.

Topic: Astrophysics and Cosmic Phenomena
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Darmois matching and <i>C</i> <sup>3</sup> matching

Abstract We apply the Darmois and the C 3 matching conditions to three different spherically symmetric spacetimes. The exterior spacetime is described by the Schwarzschild vacuum solution whereas for the interior counterpart we choose different perfect fluid solutions with the same symmetry. We show that Darmois matching conditions are satisfied in all the three cases whereas the C 3 conditions are not fulfilled. We argue that this difference is due to a non-physical behavior of the pressure on the matching surface.

Topic: Black Holes and Theoretical Physics
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Developing Methods and Measures to Assess Progress in Achieving Access Goals of the Americans with Disabilities Act: A Case Study of Small Towns in Montana

The Americans with Disabilities Act (ADA) was enacted without any baseline data against which to measure progress on achieving its public access goals. To date, no one has collected local, state, or national data to establish such a baseline or to assess progress in achieving those goals empirically. We developed a simple accessibility assessment tool that can aggregate data across businesses and communities. We then established a sampling frame for all Montana incorporated communities with populations of 2,500 – 10,000. We randomly selected 327 businesses to observe from a universe of 2,151 businesses that met inclusion criteria, and we trained accessibility advocates across the State to conduct observations. These advocates observed 236 businesses in 19 communities. Combining ratings across nine categories of accessibility, the State’s small cities and towns achieved an overall accessibility rating of 66.5% (2.66 on a 4-point scale), including average ratings of 2.74 for municipal parking availability, 1.91 for municipal parking accessibility, 2.28 for private parking availability, 1.98 for private parking accessibility, 2.91 for the safety and accessibility of municipal routes to businesses, 3.01 for private routes to businesses, 2.80 for accessibility of business entries, 2.42 for accessibility of business doorways, and 3.09 for accessibility of business interiors. Using these data, we identified 86 businesses (35.9% of the sample) that had at least one barrier that would likely preclude a person using a wheelchair from doing business there. This report presents exploratory analyses of the relationship between accessibility ratings and demographic and economic variables. Results are discussed in terms of the value of having longitudinal data that can represent the accessibility of communities over time.

Topic: Healthcare innovation and challenges
Subfield: Education
Field: Social Sciences
Domain: Social Sciences