jimnoneill/paper-to-field-training huggingface dataset:
Modulating effects of red wine and beer on heterocyclic aromatic amines carcinogenesis

It is generally accepted that about one-third of all cancers are related to dietaryfactors. Cooking conditions and dietary culture play a major role in ingestion of foodbornemutagens/carcinogens, such as heterocyclic aromatic amines. These are producedunder normal household cooking conditions from foods rich in protein, such as, meat andfish. Moreover, the effects of these genotoxic compounds on human carcinogenesis willbe influenced by the metabolic activation, detoxification and cellular responses to DNAdamage, involving phase I and II enzymes, such as cytochrome P450 enzymes, NATs,SULTs and UGTs. In humans, these enzymes are inducible and exhibit polymorphicvariation. Thus, differences in biotransformation capacity are a result of both geneticvariation in the expression and the forms of enzymes (polymorphism) as well as dietaryconstituents that modulate the expression and enzyme activity.Several studies support the assumption that a number of red wine and beercomponents can inhibit the activity of CYP1A1 and CYP1A2 and suppress heterocyclicaromatic amines genotoxicity. Additionally, the detoxifying activity of GST can beincreased by the intake of red wine and beer. All these aspects indicate that these twobeverages can interfere with enzyme activity involved in the metabolism of heterocyclicaromatic amines and protect against DNA damage and cancer induction by heterocyclicaromatic amines. On the other hand, formation of heterocyclic aromatic amines in cookedmeat, the major source of these compounds in the diet, can be reduced by the use of redwine or beer marinades.This chapter describes the modulating effects of red wine and beer on heterocyclicaromatic amines carcinogenesis, including the influence of some components of thesebeverages on modification of metabolic activation or detoxification activities of HAAsand how to minimize the formation of HAAs during cooking through the use of red wineand beer.

Topic: Carcinogens and Genotoxicity Assessment
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
IMPLEMENTATION OF REGIONAL REGULATION NUMBER 2 OF 2021 CONCERNING THE IMPLEMENTATION OF THE PROTECTION OF WOMEN AND CHILDREN

Cases of domestic violence are of such high urgency that the state both preventively and repressively prevents and overcomes these problems so as to provide guarantees regarding order and security in social life. In the current era of decentralisation, integrally and holistically the Regional Government in carrying out regional autonomy based on the principle of medebewind is obliged to make implementing regulations of the Law both in the form of Regional Regulations, as well as Regional Regulation of Majalengka Regency Implementing Agencies, and Regional Regulation of Majalengka Regency Implementing Programs. Seeing the seriousness of the number of domestic violence cases in Majalengka, which is getting higher every year, the Regional Government of Majalengka Regency normatively issued Regional Regulation of Majalengka Regency Number 2 of 2021 concerning the Implementation of Protection of Women and Children, and in action the implementer of the Regional Regulation is equipped with an implementing agency implementing the regional regulation, namely the Majalengka Regency Office of Women's Empowerment, Child Protection and Family Planning . The results showed that the implementation of Majalengka Regency Regional Regulation Number 2 of 2021 and the role of Women's Empowerment, Child Protection and Family Planning Majalengka Regency were considered successful in resolving domestic violence cases that occurred in Majalengka Regency in a non-litigation or mediation manner, thus it has become the duties and functions of Women's Empowerment, Child Protection and Family Planning Majalengka Regency to handle domestic violence cases at the non-litigation or mediation level in a family manner with the relevant parties.

Topic: Gender and Women's Rights
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Thrips Species Composition on Grapes in Karnataka and Maharashtra

A survey was undertaken to document species composition of thrips on grape foliage, inflorescence and different stages of berry development such as mustard size (2 mm), sorghum size (4 mm), pea size (8 mm) and beyond pea size (&gt; 8 mm) berries at Bijapur in Karnataka and Sangli in Maharashtra during January 2005 to January 2006. Cultivars sampled were Thomson Seedless, Sonaka, Sharad Seedless, Tas-A-Ganesh, 2A and B5 clones of Thomson seedless. Scirtothrips dorsalis Hood constituted over 90% of total thrips sampled from new flushes, inflorescence and berries in different stages during January, February, March and December 2005 at Bijapur followed by Thrips palmi Karny (1- 4.3%); Thrips hawaiiensis (Morgan) a hitherto unknown thrips species on grape dominated inflorescence (98.0%) on cv. Sonaka during December 2005 in the same area. Similar trend was observed in the vineyards of Sangli. Number of thrips, which was more on inflorescence declined as the berry matured. Least number of thrips was observed on berries &gt; pea size. As recorded in Bijapur, T. hawaiiensis was dominant species on inflorescence of 2A (98.6%) and B5 (99.4%) clones of Thompson seedless. In other cultivars S. dorsalis was dominant that formed 92.8 -100% of total thrips collected. Thrips palmi constituted 0.8-1.7% of thrips collected from different parts of grape vine. Other unidentified thrips constituted 0.9-7.2%.

Topic: Insect-Plant Interactions and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Altruistic Lying in an Alibi Corroboration Context: The Effects of Liking, Compliance, and Relationship between Suspects and Witnesses

Abstract Police investigators, judges, and jurors are often very skeptical of alibi witness testimony. To investigate when and why individuals lie for one another, we conducted two studies in which witnesses' support of a false alibi was observed. We varied the level of social pressure exerted on witnesses and the level of affinity between suspect–witness pairs. During a study session purportedly intended to investigate dyadic problem‐solving ability, a mock theft was staged. When questioned, participants were provided the opportunity to either corroborate or refute a confederate's false alibi that the latter was with them when the theft occurred. Participants were more likely to lie for the confederate when the latter explicitly asked participants to conceal his/her whereabouts during the time of the theft (Study 1). How much participants liked the suspect did not impact lying; however, participants lied for a confederate more often when the latter was a friend rather than a stranger (Study 2). Results show that alibi witnesses often lie and that investigators and jurors may not accurately estimate the likelihood that such witnesses will lie for one another. Witnesses who lied also reported doing so more often because they believed that the suspect was innocent rather than guilty. Copyright © 2016 John Wiley &amp; Sons, Ltd.

Topic: Deception detection and forensic psychology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
CCDC 963195: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: X-ray Diffraction in Crystallography
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer

Chimeric antigen receptor (CAR) T cells represent a novel targeted approach to overcome both quantitative and qualitative shortfalls of the host immune system relating to the detection and subsequent destruction of tumors. The identification of antigens expressed specifically on the surface of tumor cells is a critical first step in the ability to utilize CAR T cells for the treatment of cancer. The 5T4 is a tumor-associated antigen which is expressed on the cell surface of most solid tumors including ovarian cancer. Matched blood and tumor samples were collected from 12 patients with ovarian cancer; all tumors were positive for 5T4 expression by immunohistochemistry. Patient T cells were effectively transduced with 2 different anti-5T4 CAR constructs which differed in their affinity for the target antigen. Co-culture of CAR T cells with matched autologous tumor disaggregates resulted in antigen-specific secretion of IFN-gamma. Furthermore, assessment of the efficacy of anti-5T4 CAR T cells in a mouse model resulted in therapeutic benefit against established ovarian tumors. These results demonstrate proof of principle that 5T4 is an attractive target for immune intervention in ovarian cancer and that patient T cells engineered to express a 5T4-specific CAR can recognize and respond physiologically to autologous tumor cells.

Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Additional file 1: of Development of a combined RLEP/16S rRNA (RT) qPCR assay for the detection of viable M. leprae from nasal swab samples

The additional file comprises: Protocol 1. Conventional extraction of M. leprae DNA from clinical specimens; pp. 1–4. Protocol 2. RLEP PCR run protocol; pp. 5–6. Protocol 3. RLEP qPCR run protocol; pp. 7–8. Protocol 4. 16S rRNA RT qPCR run protocol; pp. 9–10. Protocol 5. Preparation of PANTA transport medium and stabilization of Mycobacterium leprae DNA/RNA in swab samples; pp. 11–13. Protocol 6. FastPrep extraction of M. leprae DNA from clinical specimens; pp. 14–17. Protocol 8. GAPDH mRNA (RT) qPCR run protocol; pp. 26–27. Table S1. Inter-assay variability; pp. 28. Table S2. Intra-assay variability; pp. 29. (PDF 265 kb)

Topic: Leprosy Research and Treatment
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
An Intervention Study to Enhance Postoperative Pain Management

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses’ knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001).

Topic: Anesthesia and Pain Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
X‐ray and optical studies of the morphology of polymer blends

Abstract Blends may be made of pairs of polymers where neither, one, or both components are crystalline. The state of compatibility for such blends may be deduced by x‐ray and light scattering. A survey of recent studies in this laboratory of several binary blends of crystalline and amorphous polymers is presented.

Topic: Polymer crystallization and properties
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Properties of UIR Bands in NGC6946 Based on Mid-Infrared Imaging and Spectroscopy with Infrared Camera on Board AKARI

Abstract We present results on mid-infrared imaging and spectroscopic observations of the nearby late-type spiral NGC6946 with the Infrared Camera on board AKARI. Based on mid-infrared imaging with the S7 (7$\mu$m) and S11(11$\mu$m) bands, we found that the S7/S11 ratios have larger values in the arm region, containing many star-forming regions, than in the interarm. Slit spectra of an interarm and a star-forming region show a series of unidentified infrared (UIR) bands at 6.2, 7.7, 8.6, and 11.2$\mu$m. The strengths of the 6.2, 7.7, and 8.6$\mu$m bands are larger relative to the 11.2$\mu$m band in the star-forming region, than in the interarm, even if the interstellar extinction of $A_V=3$mag towards the star-forming region is taken into account. The increase in the 6.2$\mu$m and 7.7$\mu$m features relative to the 11.2$\mu$m feature is consistent with the ionization model of PAHs. The ratio of the UIR features to the plateau emission under the 7.7$\mu$m and 8.6$\mu$m features and/or the ratio of the 7.6$\mu$m/7.8$\mu$m components in the 7.7$\mu$m feature increase in the star-forming region compared to the interarm. This variation can be accounted for by the hypothesis that the photo-evaporation of PAH clusters produce small free-flying PAHs in the star-forming region. The ratios of 6.2$\mu$m/11.2$\mu$m, 7.7$\mu$m/11.2$\mu$m, and 8.6$\mu$m/11.2$\mu$m may be tools to measure the star-formation activity in remote galaxies if these ratios and their variations are well examined and established for a large sample.

Topic: Astrophysics and Star Formation Studies
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Accuracy Evaluation of Surface-Based Registration Methods in a Computer Navigation System for Hip Surgery Performed Through a Posterolateral Approach

Many computer navigation systems have recently been developed for brain surgery, and the use of such systems in orthopedic surgery is increasing. Intraoperative registration of preoperative images is one of the most important steps in controlling the overall accuracy of computer navigation systems. Various parameters, such as CT-scan slice thickness, reconstruction pitch, intraoperative data sampling area, and data sampling volume, may affect the accuracy of registration. The purpose of this study was to evaluate the effect of the aforementioned parameters on the accuracy of registration for hip surgery performed through a posterolateral approach, and to find a clinically suitable trade-off between accuracy and surgical invasiveness.Materials and Methods: One cadaveric pelvis and one cadaveric femur were used for this study. Four alumina ceramic balls with a diameter of 28 mm and within 1 micrometer of sphericity were attached to the pelvis, and three similar balls attached to the femur, to determine relative position. CT-scan images of the pelvis and femur were obtained with a helical scanner. Three sets of slice thickness and slice pitch were chosen for data acquisition, and two additional sets of reconstructed data were made. Bone contours were extracted by cutting out the surrounding substrate at a given CT number threshold, and surface models of the bone were made from the resultant data. The positions of the pelvis and femur were tracked by LED markers attached to the bone using an optical three-dimensional position sensor (OPTOTRAK). Registration of the computer models to the real objects was performed by measuring the position of a certain number of surface points on each object with an OPTOTRAK pen-probe.Results and Conclusion: Slice thickness and reconstruction pitch affected the accuracy of registration. As the sampling area was expanded from the periarticular area to the distant peripheral area, accuracy increased slightly. Accuracy did not increase when the whole area was used, but in fact decreased, especially in the femur. The positive effect of increasing the number of sampling points was saturated at 30 points when the surface of the periarticular area was sampled. The following trade-off between accuracy and invasiveness, in terms of various parameters of preoperative and intraoperative data, is proposed as clinically optimal: perform the CT scan with 3-mm slice thickness and 1-mm reconstruction pitch, and sample the periarticular area with 30 sampling points. With these parameters, the accuracy of registration was 1.2 mm and 0.9 degrees of bias with 0.7 mm and 0.3 degrees of RMS in the pelvis, and 1.4 mm and 0.6 degrees of bias with 1.3 mm and 0.3 degrees of RMS in the femur.

Topic: Advanced X-ray and CT Imaging
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Variation in the gene encoding a major merozoite surface antigen of the human malaria parasite<i>Plasmodium falciparum</i>

Plasmodium falciparum merozoites have a variable surface protein of about 195,000 molecular weight which may be involved in strain-specific immunity. We have cloned and sequenced a major portion of the gene encoding this antigen from the CAMP strain and have located sites of preferred mung bean nuclease cleavage around the gene. These sites depend on reaction conditions, but at 40% formamide and 2 units of mung bean nuclease per microgram DNA, the intact gene was excised from the chromosome. Comparison of the CAMP strain gene with the same gene from other strains of P. falciparum by matching available DNA sequences and by DNA hybridization revealed five regions of homology separated by divergent segments. Two of the variable regions encoded three amino acid repeats, predominantly Ser-Gly-Thr and Thr-Glu-Glu. Implications of these findings on the function of the antigen, and possible mechanisms for generation of variants are discussed.

Topic: Malaria Research and Control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Effect of reduced‐intensity conditioning and the risk of late‐onset non‐infectious pulmonary complications in pediatric patients

Abstract Objective Late‐onset non‐infectious pulmonary complications ( LONIPC s) contribute to higher morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo‐ HSCT ). Therefore, we investigated the risk factors of LONIPC s in pediatric patients. Method Between 2001 and 2011, 74 pediatric patients (range, 7 months to 22.7 years old; median 6.5 years old), including 29 with a primary immunodeficiency, underwent 80 allo‐ HSCT s at our institution. Sixty‐seven patients who survived more than 3 months after allo‐ HSCT were analyzed retrospectively. The median follow‐up period was 1 973 days (range, 126‐5 145 days). Results Nine patients (13.4%) developed LONIPC s between 90 and 3 578 days after allo‐ HSCT . A myeloablative conditioning ( MAC ) regimen and chronic GVHD were determined as significant risk factors of LONIPC s. None of 18 patients who received the reduced‐intensity conditioning ( RIC ) regimen developed LONIPC s, although there was no difference in overall survival between the MAC and RIC regimen. Notably, two immunodeficient patients who received busulfan‐based MAC regimen under 2 years old developed LONIPC with no history of chronic GVHD after 5 years and 10 years from SCT , respectively, suggesting the direct toxicity of busulfan. Conclusion Our study's findings indicate that the RIC regimen reduces the risk of LONIPC s in pediatric patients.

Topic: Hematopoietic Stem Cell Transplantation
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Sociological Concepts as an Aid to Social Work Analyses

Journal Article Sociological Concepts as an Aid to Social Work Analyses Get access Pauline V. Young Pauline V. Young Search for other works by this author on: Oxford Academic Google Scholar Social Forces, Volume 7, Issue 4, June 1929, Pages 497–500, https://doi.org/10.2307/2570008 Published: 01 June 1929

Topic: Contemporary Sociological Theory and Practice
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Effects of plowing on the growth of seminal and nodal roots and on root branching of maize (&lt;i&gt;Zea mays&lt;/i&gt; L.) in upland fields converted from paddy fields in Andosol

これまでの研究から，ロータリ耕と比較してプラウ耕 （チゼルプラウで粗耕起後にパワーハローで砕土する体系） における土壌深さ8 cm以深の土壌は硬く，肥料が土壌表層に集中し，トウモロコシの根系はプラウ耕による土壌硬度の影響でロータリ耕と比べて第7葉期以降に浅根化することが明らかとなった．そこで，黒ボク土の水田転換畑におけるプラウ耕がトウモロコシの種子根と節根に及ぼす影響を調べ，浅根化した要因を解析した．試験は，施肥区と無施肥区を設けてロータリまたはチゼルプラウ （プラウ） で耕起し，土壌表層 （土壌深さ0-10 cm） の根系を調査した．ロータリ耕に比べてプラウ耕では，第3葉期までと乳熟期の種子根の根長密度は低かったが，第6葉期以降の節根の根長密度は高く，節根の分枝根が第6葉期と雄穂形成期で多く，乳熟期の節根の1次根長も長かった．第6葉期以降に種子根の根長密度は減少するが，節根の根長密度は増大し，さらに耕起法の違いによりロータリ耕よりプラウ耕で増大することから，プラウ耕による浅根化の要因は耕起法の違いが節根の伸長と分枝に影響を及ぼしたためと結論された．

Topic: Crop Yield and Soil Fertility
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Immediate Complete Overdenture for Esthetic Consideration of the Upper Edentulous Ridge - A Case Report

Background: Nowadays esthetics is one of the main considerations. So, dentures not only rehabilitate functions, but esthetics as well. The problem is that “conventional denture making” requires several steps which sometimes force a patient into a toothless phase which affects both functional and esthetical aspects. In some cases, the patients are unable to endure this condition due to esthetic reasons. Immediate dentures will be the best solution for them. Purpose: To provide information about immediate complete overdenture design and fabrication. Case: A 61-year-old female patient, an active physician, came to the Dental Hospital of Airlangga University, complaining about her upper partial denture and lower complete denture, which had been worn for 10 years. They weren’t comfortable to wear anymore. She wanted new dentures, without the toothless phase. The remaining teeth were 16, 13, 12, and 22. 13 and 22 were used as retainers for the upper partial denture but the inclination and vitality of the teeth were bad. Case management: Immediate complete overdenture was made for the upper edentulous ridge. Immediate treatment was chosen because of the esthetic consideration. Overdenture treatment was chosen because it preserves the bone dimensions. 16 and 12 were extracted, while 13 and 22 were endodontically treated. The complete denture was then fabricated by cutting of 13 and 22 on the functional model. After the complete denture had been fabricated, the patient’s teeth 13 and 22 were decaputated as high as the gingival level and then restored with GIC on the surface. The denture was then inserted immediately after the decaputations. Discussion: An immediate denture is a denture which is made first before decaputation or extraction, then immediately inserted into the mouth after the tooth decaputation or extraction. Designing an immediate denture will give some advantages to patients, especially from the esthetic aspect. An overdenture is a good treatment for patients whose condition of teeth crowns is bad but periodontal tissue and teeth roots are in good condition. In conclusion, an immediate denture is the best treatment where esthetics is the main consideration

Topic: Periodontal Regeneration and Treatments
Subfield: Urology
Field: Medicine
Domain: Health Sciences