jimnoneill/paper-to-field-training huggingface dataset:
Effect of Integrated IT Systems on Enterprise Competitiveness at Time of “Industry 4.0”

The objective of this chapter to examine the effects of integrated information systems on enterprise competitiveness. The results of the authors' research on 168 large enterprises that are active in Poland are presented. The research hypotheses posited relate to the effects of information technologies on enterprise competitiveness in respect to any integrated IT systems in place. The dependence was measured from the four perspectives of a Strategic Scorecard; namely, the customer, development, internal processes, and financial perspectives. The theoretical section of the paper applies a critical review of specialist literature that concerns integrated IT systems and enterprise competitiveness in the era of Industry 4.0. The conducted research has clearly shown that an enterprise can gain a competitive advantage by using advanced data analysis and its application in the management process.

Topic: Business and Economic Development
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
A brownmillerite electronic material LiBiFe <sub>2</sub> O <sub>5</sub> : structural, dielectric, electrical, and ferroelectric properties for device application

A lead-free brownmillerite ferroelectric material LiBiFe2O5 (LBFO) has been synthesized via a solid-state reaction technique. Using the procedure of N-TREOR method of X-ray diffraction, the crystal structure of the prepared sample is found to be monoclinic with lattice parameters: a = 13.6726 Å, b = 4.1560 Å, c = 8.5317 Å, and β = 102.89˚. Based on analysis of electrical data, the existence of Koop's and Maxwell–Wagner relaxation phenomena and dielectric relaxation in the material has been confirmed. This analysis has also shown a high impact of the dielectric permittivity (ϵr) and low tangent loss (tanδ) on using the material in some electronic devices. A detailed study of the frequency-temperature-dependent ac conductivity has suggested the presence of Jonscher's universal power law in the material. As the material has thermistor constant (β) values of 4019.26, 11535.75, and 484.36 in different temperature ranges indicating high-temperature NTC thermistor application.

Topic: Ferroelectric and Piezoelectric Materials
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Account of practice: using action learning to develop and educate undergraduate management degree apprentices

This account of practice offers an example of the use of action learning within the undergraduate Degree Apprenticeship Curriculum of a UK university, specifically the Chartered Manager Degree Apprenticeship. This programme is aimed at an age-diverse group who are supported by their employers through the levy to improve their knowledge, skills and behaviours in alignment to the standards required in becoming a Chartered Manager. We discuss the background and context of the course followed by an account of some aspects of the action learning process used to support and challenge apprentices as they worked on their projects. The account suggests that the application of knowledge to work-based problems on the Degree Apprenticeship Programme was enhanced by the action learning process. We reflect on the challenges and opportunities presented by introducing action learning on this undergraduate programme, such as the value of the safe space created and the difficulties of getting to grips with reflection.

Topic: Organizational Learning and Leadership
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Updating interleukin‐6 classic‐ and trans‐signaling

Abstract The cytokine interleukin‐6 has been identified and cloned among others as B‐cell stimulatory factor, hepatocyte stimulating factor, plasmacytoma growth factor, and interferon beta‐2. Consequently, it emerged, that IL‐6 controls a huge variety of cellular functions, among them induction of the acute phase response in the liver, mediation of inflammation and malignant transformation. In this review, we summarize the so called classical IL‐6 signaling, which is mediated by the complex of IL‐6, the membrane bound IL‐6R and two gp130 molecules, and an alternative pathway called trans‐signaling, which apparently contributes to the development of chronic inflammation and cancer. During trans‐signaling an agonistic soluble IL‐6R is generated, which sensitizes cells lacking the membrane bound IL‐6R. Finally, we discuss specific inhibition of IL‐6‐trans‐signaling processes by a naturally occurring soluble form of gp130, demonstrating that this protein may emerge as an important future therapeutic in clinical applications for chronic inflammation.

Topic: Cytokine Signaling Pathways and Interactions
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The approach of candidate teachers towards socio-scientific issues: The space researches example

The purpose of this study is to identify the approaches of candidate teachers towards socio-scientific issues. To this end, 42 candidate teachers doing their pedagocgical formation program in 2015-2016 academic year were put through a study on the socio-scientific topic Space Researches. Of the 42 candidate teachers, 4 are physics students; 22 are chemistry students and 16 are biology students. The research pattern was determined as scanning and a text which describes the positive and negative aspects of Space Researches was prepared to collect data. The candidate teachers were given the text and their views on space researches were asked. Their answers were analyzed via content analysis method. According to the results, the majority of the candidate teachers are in favor of space researches (%71,43). The rationale of the candidate teachers who supported these researches was the fact that it has more benefits than harms, they are required for the development of the country, they help the formation of the future and they believe the world will be rendered more liveable thanks to these researches. Those candidate teachers who adopted a negative approach towards space researches (28.57%) justified their opinion by saying that these researches have negative sides that are still in the dark, people are exposed to more radiation, they inflict damage on the country's economy, they leads to consumerism due supporting new technological advancement, they lead to an increase in carcinogens, the results of the researches are not announced to the public objectively, it increases dependence on technology and they contaminate the Earth beyond the limits of liveability. The candidate teachers that are in favor of space researches express that they consider the researches are reliable since the harms that emerge during researches can be minimized. On the other hand, the candidate teachers who are of the opposite idea argue that those harms can never be wiped out and that the budgets set fr these researches should be used for researches devoted to improving human health. Identifying the views of teachers - physical sciences teachers in particular - on current researches is essential in that these views give insight about their approaches towards their students. © The Turkish Online Journal of Educational Technology.

Topic: Scarabaeidae Beetle Taxonomy and Biogeography
Subfield: Paleontology
Field: Earth and Planetary Sciences
Domain: Physical Sciences
A new method allowing long‐term potentiation recordings in hippocampal organotypic slices

Abstract Background Hippocampal organotypic slices are used to improve the understanding of synaptic plasticity mechanisms because they allow longer term studies compared to acute slices. However, it is more delicate to keep cultures alive in the recording system outside in vitro conditions. Experiments from the organotypic cultures are common but the handling of slices is rarely described in the literature, even though tissue preservation is crucial. Instruments are sometimes required to extract the slices from the culture inserts but this approach is delicate and can lead to damage, given how strongly the slices are attached to the insert. Methods A new configuration is proposed to secure the transfer of slices from the incubator to the recording chamber through an adaptor piece that can be designed for any model of chamber and/or insert. The adaptor is a Plexiglas ring in which a culture insert containing the slice can be easily introduced and stabilized. This system allows slices to be placed in the interface for electrophysiological investigations without having to detach them from the insert. That way, no damage is caused and the recording system can safely hold the slices, maintaining them close to culture conditions. Results In addition to the description of the adaptation system, slices were characterized. Their viability was validated and microglial expression was observed. According to the experimental conditions, neuroprotective ramified microgliocytes are present. Dendritic spines studies were also performed to determine neuronal network maturity in culture. Moreover, SKF 83822 hydrobromide and three trains of 100 pulses at 100 Hz with a 10‐min inter‐train interval are suggested to induce long‐term potentiation and to record an increase of fEPSP amplitude and slope. Conclusion This paper provides detailed information on the preparation and characterization of hippocampal organotypic slices, a new recording configuration more suitable for cultures, and a long‐term potentiation protocol combining SKF and trains.

Topic: Neuroinflammation and Neurodegeneration Mechanisms
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Novel Strategy for Generation and Titration of Recombinant Adeno-Associated Virus Vectors

ABSTRACT Recombinant adeno-associated virus (rAAV) vectors have many advantages for gene therapeutic applications compared with other vector systems. Several methods that use plasmids or helper viruses have been reported for the generation of rAAV vectors. Unfortunately, the preparation of large-scale rAAV stocks is labor-intensive. Moreover, the biological titration of rAAV is still difficult, which may limit its preclinical and clinical applications. For this study, we developed a novel strategy to generate and biologically titrate rAAV vectors. A recombinant pseudorabies virus (PrV) with defects in its gD, gE, and thymidine kinase genes was engineered to express the AAV rep and cap genes, yielding PS virus, which served as a packaging and helper virus for the generation of rAAV vectors. PS virus was useful not only for generating high-titer rAAV vectors by cotransfection with an rAAV vector plasmid, but also for amplifying rAAV stocks. Notably, the biological titration of rAAV vectors was also feasible when cells were coinfected with rAAV and PS virus. Based on this strategy, we produced an rAAV that expresses prothymosin α (ProT). Expression of the ProT protein in vitro and in vivo mediated by rAAV/ProT gene transfer was detected by immunohistochemistry and a bioassay. Taken together, our results demonstrate that the PrV vector-based system is useful for generating rAAV vectors carrying various transgenes.

Topic: Virus-based gene therapy research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Relative intensity noise characteristics of frequency stabilised grating-coupled modelocked semiconductor laser

Relative intensity noise (RfN) characteristics of a frequency stabilised grating-coupled modelocked semiconductor laser (MSL) have been experimentally investigated. Reported is the first measurement, to the authors' knowledge, of general RIN characteristics as well as RIN reduction in the frequency stabilised MSL system showing the relationship between RIN and mode coherency in the MSL.

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Epithelial mesenchymal transition in human menstruation and implantation

The endometrium during the sexual cycle undergoes detachment, tissue remodeling, and differentiation during the menstrual cycle. Localized and transient destruction and regeneration of endometrial tissue are also essential for pregnancy. It is possible to attribute many causes of failure in infertility treatment to the implantation stage. To improve the success rate of plateau fertility treatment, it is important to understand the regeneration mechanism of the endometrium, a unique regenerative tissue in the human body. In association with cell proliferation, tissue remodeling requires the relocation of proliferative cells, and the steady-state epithelial cells need to be motile for the relocation. Transient add-on motile activity in epithelial cells is mediated by epithelial to mesenchymal transition (EMT) and reversible mesenchymal to epithelial transition (MET). The destruction and regeneration of endometrial tissue over a period of days to weeks requires a system with a rapid and characteristic mechanism similar to that of wound healing. Here, I review the relationship between the well-known phenomenon of EMT in wound healing and endometrial tissue remodeling during the sexual cycle and pregnancy establishment, which are automatically triggered by menstruation and embryonal invasion.

Topic: Reproductive System and Pregnancy
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Spontaneous Memorials: Forums for Dialog and Discourse

AbstractAbstractThrough the contemporary mourning ritual of spontaneous memorialization, Americans are developing a new forum for civic discourse. As sites where individuals congregate for communal consolation and remembrance in response to local and national crises, spontaneous memorials foster multicultural and intergenerational interactions. In direct peer-to-peer conversations, by indirect messaging through letters, poetry, songs and prayers, and via representational objects and artworks, citizens express and collectively exhibit the moral and civic values held by their communities. Though in-depth evaluation is needed, museums might consider using the framework of spontaneous memorialization to foster dialog and discourse within their communities. This article focuses on memorials created in Oklahoma City following the 1995 bombing of the Alfred P. Murrah Building, those across Manhattan after the collapse of the World Trade Center in 2001, and related museum activities that ensued.

Topic: Memory, Trauma, and Commemoration
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Nazirites in Late Second Temple Judaism: A Survey of Ancient Jewish Writings, the New Testament, Archaeological Evidence, and Other Writings from Late Antiquity. By STUART CHEPEY.

This volume, a revision of a doctoral dissertation written in Oxford under the supervision of Martin Goodman, is a summary and analysis of the evidence for Nazirites from c.200 bc to ad 70. The overall aim is limited to surveying the material, assessing its historicity, and identifying what presuppositions about the Nazirate underlie it. On the other hand, ‘what this study is not attempting to do it to write a complete history of the Nazirate or the institution of the Nazirite vow in this era’ (p. 15). Perhaps surprisingly, there has been no major study of the Nazirate since a dissertation by H. Salmanowitsch in 1931, so the present volume attracts some welcome attention to this fascinating subject. An introduction has a brief sketch of Numbers 6 and the biblical passages about Samson, Samuel, and the Nazirites in Amos. It also surveys some recent studies of the Nazirite vow, including especially those which have an eye on New Testament discussions of the Synoptic Gospels and Acts. There is a brief statement on method: the study proceeds in chronological order, including all potential evidence, whether it turns out to be useful or not.

Topic: Biblical Studies and Interpretation
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Quality of life in ambulatory pulmonary arterial hypertension in connective tissue diseases and its relationship with risk stratification

The Pulmonary Arterial Hypertension Symptoms and Impact Questionnaire (PAH‐SYMPACT) is a PAH‐specific patient‐reported outcome scale assessing patients’ quality of life from four aspects: cardiopulmonary symptoms, cardiovascular symptoms, physical impacts and cognitive/emotional impacts. This study aimed to validate the Chinese version of PAH‐SYMPACT and explore its relationship with risk stratification in patients with connective tissue disease‐associated pulmonary arterial hypertension (CTD‐PAH). In addition, 75 patients with CTD‐PAH confirmed by right heart catheterization were invited to complete questionnaires including PAH‐SYMPACT, the 36‐item Medical Outcomes Study Short Form Survey (SF‐36) and EuroQol five dimensions questionnaire (EQ‐5D). The demographic, clinical, laboratory and treatment data were collected. The endpoint was treatment goal achievement status in 6–12 months after completing the questionnaires, defined as an integrated outcome. Participants’ mean age was 36.4 ± 11.9 years and the mean pulmonary arterial pressure was 38.9 ± 13.67 mmHg. The reliability of the PAH‐SYMPACT domains ranged from 0.83 to 0.88. Results of factor analysis basically conformed the original PAH‐SYMPACT. The treatment goal achievement (TGA) status in 6–12 months was significantly associated with physical impacts scores (odds ratio: 0.180, 95% confidence interval: 0.036–0.908, P=0.038). The Chinese version of PAH‐SYMPACT is a reliable measurement to evaluate quality of life in CTD‐PAH patients and is also a potential predictor of patient’s condition change in routine clinical practice.

Topic: Pulmonary Hypertension Research and Treatments
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Pendampingan Pendalaman Materi Matematika Berbasis Etnomatematika untuk Siswa Kelas VII SMPN 2 Sekampung Udik

Learning conducted online during the pandemic caused several problems for schools in areas where internet access was difficult, including students finding it difficult to understand the material, especially mathematics subjects because they quickly got bored and did not get all the material in the curriculum. This service will link mathematics with culture which is called ethnomathematics. The purpose of this service is to assist students in understanding mathematical material by assisting in an effort to deepen mathematics material for seventh grade students at SMPN 2 Sekampung Udik, East Lampung. The implementation method uses participatory action research (PAR) with stages in the form of preparation, implementation, evaluation and reflection. The culture used and closer to the subject of mentoring is the local culture of Lampung in the traditional game Taplak / Suksuk Lampung on a flat wake. This mentoring activity went well and received a positive response from participants and teachers

Topic: Online Learning Methods and Innovations
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Atypical Reserve Cell Hyperplasia of Cervical Glands, Simulating Adenocarcinoma. An Undescribed Reversible Lesion in a Woman Taking Oral Contraceptives

On the basis of a characteristic lesion of the endocervical mucosa in a woman who had taken contraceptives for 4 years, the authors review the problem of these alterations, also in light of their personal experience.

Topic: Cancer and Skin Lesions
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Supplementary Figure Legend from Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth–inhibitory activity

Supplementary Figure Legend from Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth–inhibitory activity

Topic: Retinoids in leukemia and cellular processes
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Corticotropin releasing hormone activates <scp>CD</scp>14<sup>+</sup> cells to induce endothelial barrier dysfunction

Abstract Endothelial barrier dysfunction is associated with the pathogenesis of a number of disorders in the body, but the aetiology is unclear. We have investigated the mechanism of the psychological stress mediator, corticotropin releasing hormone (CRH), on compromising the endothelial barrier function. Human endothelial cell line, Hmvec cells, was cultured in monolayers as a model of endothelial barrier. Human peripheral CD14 + cells were collected to be used as effector immune cells. The transepithelial resistance (TER) and permeability of horseradish peroxidase (HRP) were used as indicators of endothelial barrier function. Apoptosis in Hmvec cells were analysed by flow cytometry. Human CD14 + cells expressed both receptors (R) of CRH, the CRH‐R1 and CRH‐R2. Exposure to CRH induced CD14 + cells to release tumour necrosis factor (TNF)‐α. CRH‐activated CD14 + cells decreased TER and increased the permeability to HRP in co‐cultured Hmvec monolayers. Co‐culture with CRH‐activated CD14 + cells increased the apoptosis in Hmvec cells. We conclude that CRH can activate CD14 + cells to produce TNF‐α and compromise endothelial barrier function by inducing apoptosis of the endothelial cells.

Topic: Stress Responses and Cortisol
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
G58 Demonstration ?The old way? of the need for modern long-term cardiovascular monitoring

We assess abut-daily (circadiaa)and about-weekly(circaseptan, CS) changesin the blocd pressure(BP) responaeto the l-rein immersion of the handinto ice water(CPT).(Anabnut-8mmHg BP increase in the CPT is repnrtcdfor hcakth; an elevation[>25mm Hg] in patients with "hypertension"is viewedas prcdiasase.Variablesrclamdto the vascular system exhibit prominent CS, circannttak and circadisns, amongothercompnnenta of dreirgeneticallyanchoredtime structureor cbronome.)A16-year-oldwoman (ML) immersctfher hand into ice watmevery24 hoursfor 2 daysandoncedailyin the morningtberesftcr for 1 week (N=25),as did, only for I day, 4 adults 20-66ycaraof age.BP and beertrate (HR) were monitoredautomaticallyat l-rein intervals beforeand immediatelyafter CPT.Data were analyzedby tbe cosinormethod.l%edifferencebetweenthefiratpost-CPTBPvalueand the meanof the last 7 values prior to the CPT was a measureof CPT respnnse(at l-rein).Overall,ML's systnlic(S) BP increaaedby 8.2 t 1.4 mm Hg and her diastolic(D) BP by 6.2 * 0.9 mm Hg (PcO.CO1).Increaseswere foundin 96% of the tests for SBP, 92% for DBP and 20% for HR.(Therewas only 1 tie for Hff [4%],rcstdtingin a HR dccreaaein 76% of CPTS.)TheBP responseto CPT at 1 min after CPT was CS-dependent.The CS doubleamplitudesarc 12.5+ 4.1 (P=0,019) for SBP and 7.8 * 2.8 mm Hg (P=O.030)forDBP, with acrnpheaes nccttrringon late Sunday,cady Monday (at -50" and -67" from CO:CO on Sunday for SBP and DBP, respectively, with 3600=1 week).The rcsponaeof HR did notatlow thedetectionofa rbytbm (P=O.%9).The circadianrc.spnnscpeakedin theearly morninghours(SBP:-80°;DBP; -1130),in keeping with results from the 4 adult subjaaa (SBP: -37°; DBP: -420),individualdifferencesnotwithstanding.The averagetiming of the krrgestoverall responseof BP m CPT coincideswith the timing nf the responseto other stimuli.The CS acrnphascscoincidewith tbe times of increased morbiditylmortality from vascular diseases demonstrated on over 100,000 cases (Corn41issen G. et al.Chronobiologia 20: 87-115,1993).Chronomes,time smucmresbrnader than circadian, notably their about-weeklycomponents, should be consideredin intcrpfctingBP resprmsesas a gaugeof vasculardisease status in adolescents,not only at the extremesof life wbcn the CS and about-half-weeklyrhythmsare particularlyprominentin BP andHR.

Topic: Cardiac Imaging and Diagnostics
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences