jimnoneill/paper-to-field-training huggingface dataset:
LHD LHDGAUSS_RAY_MWRM3 #153735.1 (analyzed)

Ray trajectories for microwave reflectometry (mwrm) at set3 point obtained using ray-tracing code LHDGauss.

Topic: DNA and Nucleic Acid Chemistry
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Studies on the NA, K-Pump in Erythrocytes of Patients with Essential and Renal Hypertension

Conference Abstract| September 01 1983 Studies on the NA, K-Pump in Erythrocytes of Patients with Essential and Renal Hypertension JH Hengstenberg; JH Hengstenberg 1Department of Medicine, Division of Nephrology, Medical School Hannover, Hannover, West Germany One of us has reported at the 1980 meeting of this Society in Bristol that in chronic non-uraemic renal patients the haemodynamic abnormalities start, while the blood pressure is still normal, with a hypervolemia and a high cardiac output to which the peripheral vascular bed on the arterial and venous side adjust. The blood pressure starts to rise at a moment when the normal peripheral adjustment ceases. Search for other works by this author on: This Site PubMed Google Scholar J Schaeffer; J Schaeffer 1Department of Medicine, Division of Nephrology, Medical School Hannover, Hannover, West Germany One of us has reported at the 1980 meeting of this Society in Bristol that in chronic non-uraemic renal patients the haemodynamic abnormalities start, while the blood pressure is still normal, with a hypervolemia and a high cardiac output to which the peripheral vascular bed on the arterial and venous side adjust. The blood pressure starts to rise at a moment when the normal peripheral adjustment ceases. Search for other works by this author on: This Site PubMed Google Scholar J Brod J Brod 1Department of Medicine, Division of Nephrology, Medical School Hannover, Hannover, West Germany One of us has reported at the 1980 meeting of this Society in Bristol that in chronic non-uraemic renal patients the haemodynamic abnormalities start, while the blood pressure is still normal, with a hypervolemia and a high cardiac output to which the peripheral vascular bed on the arterial and venous side adjust. The blood pressure starts to rise at a moment when the normal peripheral adjustment ceases. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1983) 65 (3): 29P. https://doi.org/10.1042/cs065029P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation JH Hengstenberg, J Schaeffer, J Brod; Studies on the NA, K-Pump in Erythrocytes of Patients with Essential and Renal Hypertension. Clin Sci (Lond) 1 September 1983; 65 (3): 29P. doi: https://doi.org/10.1042/cs065029P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1983 The Biochemical Society and the Medical Research Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Electrolyte and hormonal disorders
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
A Comparison Between Thermospray and Particle Beam LC/MS for Environmental Applications

A study is described comparing thermospray LC/MS and Particle Beam LC/MS techniques. The two systems are examined on the basis of applicability, quantitative and qualitative performance. On the basis of this study, the conclusions are drawn that the two techniques are roughly equivalent in both applicability, and quantitative performance, but generate different types of spectral information.

Topic: Fluid Dynamics and Heat Transfer
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
THE IMPORTANCE OF ADEQUATE STEM ANTEVERSION FOR ROTATIONAL STABILITY IN THA. AN RSA-STUDY WITH 5 YEARS FOLLOW UP.

Introduction: Progressive retroversion of the stem within the femur has been suggested to be an important initial mode of hip prosthesis failure. We have assessed the relationship between postoperative stem anteversion angle, measured with CT, and the rotational stability as measured with repeated radiostereometric analysis (RSA) with 5 years follow up. Patients and methods: 57 patients were operated on with THA using a cemented, matt and collared stem. The achieved stem anteversion angles were measured postoperatively with 3-D CT-examinations. The patients were divided into three groups depending on their ante-version angle: ≤10°, 11°–25° and ≥25°. They were followed with repeated RSA examinations for 5 years to determine the stem migration pattern. Results: The mean postoperative anteversion angle was 20.5° (range 1°–43°). At 5 years, all except one stem had rotated into retroversion. There was a strong correlation between the postoperative anteversion angle and later rotation into retroversion (p=0.007). The group with ≤10° of stem anteversion rotated significantly more into retroversion, seen as early as 3 months (p=0.02), but more obvious at 5 years (p=0.002) with a mean of 9.9° of retroversion compared to 3.8° in the 11°–25° group and 2.4 ° in the ≥25° group. The distal stem migration results were accordant with more migration at 5 years (p=0.008) for the ≤10° anteversion group (1.6 mm subsidence compared to 0.5 and 0.3 mm respectively). Two stems have been revised because of aseptic loosening, both with a low initial anteversion angle (7° and 1°) and large retroversion at 5 years (7 ° and 31° respectively). Conclusion: Measured by RSA, rotation into retroversion of the femoral stem was a regular finding in this study using a conventional prosthesis design. We propose that such rotation is a common finding in hip arthroplasty, but the degree may be design sensitive. Our results strongly suggest that the initial rotational position of the femoral component during surgery is decisive for the degree of later retroversion and probably prosthetic longevity; the less anteverted position the more the stem will migrate into a more retroverted position after the operation. This rotational migratory pattern is correlated to subsidence and eventual loosening. Hence, meticulous attention should be paid to the rotational position of the femoral stem during surgery, with less than 10° of anteversion appearing deleterious. However, too much anteversion will risk impingement and possibly other unwanted biomechanical effects, and an upper limit still remains to be established.

Topic: Orthopaedic implants and arthroplasty
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
The differentiability of convex functions on topological linear spaces

In this paper topological linear spaces are categorised according to the differentiability properties of their continuous convex functions. Mazur's Theorem for Banach spaces is generalised: all separable Baire topological linear spaces are weak Asplund. A class of spaces is given for which Gateaux and Fréchet differentiability of a continuous convex function coincide, which with Mazur's theorem, implies that all Montel Fréchet spaces are Asplund spaces. The effect of weakening the topology of a given space is studied in terms of the space's classification. Any topological linear space with its weak topology is an Asplund space; at the opposite end of the topological spectrum, an example is given of the inductive limit of Asplund spaces which is not even a Gateaux differentiability space.

Topic: Advanced Banach Space Theory
Subfield: Mathematical Physics
Field: Mathematics
Domain: Physical Sciences
Characterization of cardiovascular and cerebrovascular controls via spectral causality analysis in patients undergoing surgical aortic valve replacement during a three-month follow-up

Bari V, Gelpi F, Cairo B, Anguissola M, Pugliese S, De Maria B, Bertoldo EG, Fiolo V, Callus E, De Vincentiis C, Volpe M, Molfetta R, Ranucci M, Porta A. Characterization of cardiovascular and cerebrovascular controls via spectral causality analysis in patients undergoing surgical aortic valve replacement during a three-month follow-up. Physiol Meas. 2023 Sep 29;44(9). doi: 10.1088/1361-6579/acf992. PMID: 37703899. Abstract Objective.Aortic valve stenosis (AVS) induces left ventricular function adaptations and surgical aortic valve replacement (SAVR) restores blood flow profile across aortic valve. Modifications of cardiac hemodynamics induced by AVS and SAVR might alter cardiovascular (CV) and cerebrovascular (CBV) controls. The study aims at characterizing CV and CBV regulations one day before SAVR (PRE), within one week after SAVR (POST), and after a three-month follow-up (POST3) in 73 AVS patients (age: 63.9 ± 12.9 yrs; 48 males, 25 females) from spontaneous fluctuations of heart period (HP), systolic arterial pressure, mean arterial pressure and mean cerebral blood velocity.Approach.CV and CBV regulations were typified via a bivariate autoregressive approach computing traditional frequency domain markers and causal squared coherence (CK2) from CV and CBV variabilities. Univariate time and frequency domain indexes were calculated as well. Analyses were carried out in frequency bands typical of CV and CBV controls at supine rest and during active standing. A surrogate method was exploited to check uncoupling condition.Main results.We found that: (i) CV regulation is impaired in AVS patients; (ii) CV regulation worsens in POST; (iii) CV regulation recovers in POST3 and CV response to active standing is even better than in PRE; (iv) CBV regulation is preserved in AVS patients; (v) SAVR does not affect CBV control; (vi) parameters of the CBV control in POST3 and PRE are similar.Significance.CK2is particularly useful to characterize CV and CBV controls in AVS patients and to monitor of patient's evolution after SAVR.

Topic: Fault Detection and Control Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
<i>In vitro</i> bactericidal activity of 465–470 nm blue light phototherapy and aminolevulinic acid on <i>Staphylococcus pseudintermedius</i>

Background Staphylococcus pseudintermedius is the principal pathogen causing bacterial skin infections in dogs. Photodynamic therapy ( PDT ) involving the combination of light and a topical photosensitizer is used to treat human skin infections. Although the antimicrobial effects of PDT have been demonstrated using in vivo and in vitro studies in humans, its effects on dogs and their pathogens are unclear. Objectives The aim of this study was to demonstrate the in vitro efficacy of PDT over a 465–470 nm spectrum to kill S. pseudintermedius using δ‐aminolevulinic acid ( ALA ) as the photosensitizer. Methods Six S. pseudintermedius isolates from canine skin were exposed to blue light‐emitting diodes ( LED s) at 465–470 nm, with or without ALA . The light doses were 18.4, 36.8 and 55.2 J/cm 2 . The number of colony‐forming units and optical densities of broth cultures were measured and then compared with Dunnett's test. Bacterial viability was monitored using fluorescence microscopy and the fluorescence intensity values were compared with a paired Student's t ‐test. Results Blue light inhibited the growth of S. pseudintermedius ; the effect significantly increased with the addition of ALA as a photosensitizer and with increasing light doses. Live/dead staining confirmed that PDT reduced bacterial viability and exerted an antibacterial effect. Conclusion and clinical importance Blue light has a strong antibacterial effect on S. pseudintermedius in a light dose‐dependent manner. ALA alone did not exhibit bactericidal action, but its combination with blue light increased the effect of PDT compared to blue light alone.

Topic: Photodynamic Therapy Research Studies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
The meta-ethical significance of experiments about folk moral objectivism

The meta-ethical commitments of folk respondents – specifically their commitment to the objectivity of moral claims – have recently become subject to empirical scrutiny. Experimental findings suggest that people are meta-ethical pluralists: There is both inter- and intrapersonal variation with regard to people’s objectivist commitments. What meta-ethical implications, if any, do these findings have? I point out that current research does not directly address traditional meta-ethical questions: The methods used and distinctions drawn by experimenters do not perfectly match those of meta-ethicists. However, I go on to argue that, in spite of this mismatch, the research findings should be of interest to moral philosophers, including meta-ethicists. Not only do these findings extend the field of moral psychology with new data and hypotheses, but they also provide tentative evidence that touches on the adequacy of theses in moral semantics and moral metaphysics. Specifically, they put pressure on arguments in support of moral realism.

Topic: Psychology of Moral and Emotional Judgment
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
The economic and job creation benefits of Ontario public libraries

Describes economic benefits of Ontario public libraries. These benefits include services and information for businesses, lifelong learners and job seekers. Ontario public libraries create work including short‐term construction work and longer‐term information infrastructure work. Provides job multiplier models for library building capital and information infrastructure capital with examples. Ontario public libraries have a direct and indirect impact on the Ontario economy, measured in terms of gross domestic product (GDP). Suggests a framework to help public libraries promote their economic impact in a time of economic restraint and funding cutbacks. This framework includes an analysis of library jobs, direct and indirect library impact on the GDP, a promotion of public electronic access to information, generation of economic‐oriented patron anecdotes, economic impact surveys and development of an entrepreneurial spirit in public libraries.

Topic: Canadian Policy and Governance
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Abstract 28: Cord Blood Derived Macrophages Promote the Differentiation of Oligodendrocyte Precursor Cells

Abstract Introduction Krabbe Disease (KD) is a rare neurodegenerative disorder caused by a mutation in the gene encoding galactocerebrosidase (GALC). GALC deficiency leads to accumulation of the toxic metabolite psychosine in myelin-forming oligodendrocytes causing severe demyelination. Presymptomatic hematopoietic stem cell transplants can slow the progression of disease, but ultimately there is no cure. We previously demonstrated that DUOC-01, a first-generation macrophage cell-therapy manufactured from banked human umbilical cord blood cells, which when injected into the corpus callosum, enhanced remyelination in immunocompromised mice treated with the demyelinating agent, cuprizone. Further, DUOC-01 could promote the maturation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes via remyelinating factors (Remy-Macs). Objectives In this study, we set out to test if DUOC-01 and their secreted Remy-Macs could rescue oligodendrocyte deficits and improve survival in GALC deficient mice. Methods First, we generated primary OPC cultures from GALC deficient mice and measured OPC maturation by immunohistochemistry and qRT-PCR of myelin basic protein (MBP). To test if DUOC-01 impacted OPCs via secreted factors, we incorporated the use of transwell assays. To test if DUOC-01 or Remy-Macs could promote remyelination in vivo, we injected DUOC-01 or used Alzet osmotic pumps to deliver therapies into the cerebrospinal fluid (CSF). Results We first tested the effects of DUOC-01 and Remy-Macs on primary OPC cultures isolated from neonatal control of GALC deficient mice. We observed comparable oligosphere growth in cultures derived from GALC deficient mice and their wild-type litter mates, indicating a normal function for twitcher OPC proliferation. However, OPC differentiation was compromised in GALC deficient mice, demonstrated by decreased MBP expression. DUOC-01 and Remy-Macs increased the production of MBP at both mRNA and protein levels. Additionally, infusion of Remy-Macs into the CSF of GALC deficient mice improved survival. Discussion Our data demonstrated that DUOC-01 or Remy-Macs promoted the differentiation of OPCs isolated from GALC deficient mice. Further, infusing Remy-Macs into the CSF of GALC deficient mice extended life span. Our data suggest DUOC-01 or Remy-Macs have the potential to be further developed into a novel cell-therapy to treat Krabbe and other demyelinating diseases.

Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Growth and carcass characteristics of heavy slaughter weight lambs: effects of sire breed and sex of lamb and relationships to serum metabolites and IGF-1

Abstract Texel (T) and Suffolk (S) sired ram, wether and ewe lambs (no = 180) were kept at grass with their dams until weaned at 20 weeks and then taken to slaughter weights of 40, 44 and 48 kg, also at grass. Sex type, but not sire breed, affected lamb growth rate (rams 293, wethers 253, ewes 224 g/day; P &lt; 0·001). Both T and S ewe lambs were fatter at slaughter in all fat depots compared with their ram and wether siblings such that rams could be slaughtered at a calculated 7·7 kg greater live weight than ewes at equal carcass fat cover. T carcasses were greater than S carcasses in eye-muscle area (793 v. 732 mm2; P &lt; 0·001) and killing-out proportion (481 v. 476 g/kg; P &lt; 0·05) but not in any fat measurement. Slaughter weight influenced killing-out proportion (P &lt; 0·001) and all fat measurements (P &lt; 0·01) but did not significantly affect eye-muscle area. Mean serum insulin-like growth factor-1 (IGF-1) concentrations (μig/l), determined during weeks 8,11, 14, 17 and 20 in a balanced subset of 84 lambs, were higher in T than in S lambs (P &lt; 0·05), in singles than in twins (P &lt; 0·01; rams and wethers only) and in rams than in either wethers or ewes (P &lt; 0·001). Mean serum IGF-1 concentration decreased between week 8 and week 20 with a greater rate of decline in singles than in twins (P &lt; 0·001). IGF-1 was more strongly correlated with live weight at 8 weeks (r = 0·629; P&lt; 0·001) than at 20 weeks (r = 0·293; P &lt; 0·05). Mean IGF-1 (weeks 8 to 20) was correlated with rate of live-weight change (r = 0·576; P &lt; 0·001). Significant differences for T and S lambs were found in the relationships between mean serum IGF-1 (weeks 8 to 20) and daily live-weight gain (weeks 8 to 20) and between mean IGF-1 and eye-muscle area at slaughter. Metabolite concentrations differed little between sire breeds and not at all between sex types.

Topic: Genetic and phenotypic traits in livestock
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Maintaining Coupled Metabolism and Membrane Function in Anoxic Brain: A Comparison Between the Turtle and Rat

352The purpose of this chapter is to review current research which addresses the important topic of tolerance to anoxia in the vertebrate brain. The chapter focuses on a comparative approach in which brain function and energy metabolism are examined in anoxia-tolerant diving turtles and in anoxia-sensitive rats. During anaerobic conditions, the most striking difference appears to be that the rat brain rapidly loses stores of high energy intermediates phosphocreatine (PCr) and ATP, while these intermediates are maintained at aerobic levels in brains of diving turtles. As a consequence, the rat brain rapidly loses all transmembrane ion gradients and electrical responsiveness. In contrast, the turtle brain maintains ion transport processes and electrical excitability for many hours under anaerobic conditions. The turtle brain appears to enter a new balanced metabolic state by taking advantage of a high anaerobic glycolytic capacity and by decreasing levels of energy utilization. Analysis of electrophysiological responses in the turtle brain indicated that energy sparing may occur through inhibition of synaptic transmission, elevation of threshold for action potential activation, and release of inhibitory neuromodulators such as adenosine. It is believed that a full understanding of the mechanisms by which anoxia-tolerant species cope without oxygen may be useful for providing alternate strategies for therapeutic intervention in conditions of hypoxia, asphyxia, cardiac arrest, and stroke in man.

Topic: Mitochondrial Function and Pathology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Tuning <i>n</i>-Alkane Adsorption on Mixed-Linker Zeolitic Imidazolate Framework-8-90 via Controllable Ligand Hybridization: Insight into the Confinement from an Energetics Perspective

Linker hybridization provides enormous tunability of structures and properties of zeolitic imidazolate frameworks (ZIFs). We synthesized hybrid ZIF-8-90 structures by using binary organic ligands and examined their compositional and structural evolution using multiple techniques including field emission scanning electron microscopy (FESEM), Raman, X-ray diffraction (XRD), thermogravimetry-differential scanning calorimetry (TG-DSC), N2 adsorption, and 1H NMR analyses. Well-designed ligand compositions of ZIF structures contribute to the continuously switchable pore structures. The average micropore diameter shrinks from 0.72 to 0.65 nm, while the mesopore width monotonically increases from 2.18 to 3.29 nm as the carboxaldehyde-2-imidazole (OHC-IM) proportion rises from 0.31 for ZIF-8-90-S1 to 0.88 for ZIF-8-90-S5. An increase in framework polarity can lead to the strengthened guest–host interaction and therefore energetically exerts a positive effect on the adsorption affinity of n-hexane on hybrid ZIF-8-90 structures. The highest n-hexane adsorption capacity is found on the ZIF-8-90-S4 sample (having OHC-IM proportion of 0.82). At a close OHC-IM proportion of 0.792, the simulation result exhibits the strongest guest–host interaction (with the largest van der Waals interaction energy).

Topic: Metal-Organic Frameworks: Synthesis and Applications
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
THE TACHISTOSCOPE ITS HISTORY &U SES

Tachistoscopic training, also known a Flash Recognition Training (FRT), is a perceptual enhancement technique designed to improve the recall of visual information. The speed and accuracy of this recall allows for integration of vision with prior experiences in an optimal manner. This article briefly reviews the history of the tachistoscope and some of the research that supports the efficacy of the tachistoscope as a diagnostic and training device. Its uses in optometry, law enforcement and military training and as a research tool in psychology are discussed, along with its application to sports vision.

Topic: Visual perception and processing mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences