jimnoneill/paper-to-field-training huggingface dataset:
Development of a Three-Dimensional Slurry Printing System Using Dynamic Mask Projection for Fabricating Zirconia Dental Implants

This study aims to develop a three-dimensional slurry printing system (3DSP) and to use a two-stage sintering process for the fabrication of zirconia dental implants. Solvent-soluble slurry which is composed of zirconia powder, visible light-curable resin, and methanol is prepared. During layer casting, the liquid slurry penetrates into the pores of the subjacent layers. The fresh layer and the subjacent layer tightly connect when the solvent dries. The mask pattern for the sliced layers is then exposed on a solvent-soluble slurry, for solidification and to form the green part that is embedded in the green block, layer-by-layer. The green block is immersed in a methanol solution, which causes the collapse of the un-exposed part. As a result, the rigid green part is obtained. Two-stage sintering is used to heat the rigid green part to 600°C to produce binder burnout and to 1450°C to sinter the zirconia dental implant part. The results show that sintered parts have an average flexural strength and micro-hardness of 539.1 MPa and 1556 HV, respectively. The zirconia dental implant is successfully fabricated using the 3DSP system developed. The proposed fabrication method using a 3DSP system is briefly described and it is proven that there is a good capacity to fabricate zirconia dental implants.

Topic: Dental materials and restorations
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Royal roads and dead ends. How institutional procedures influence the coherence of European Union policy formulation

The European Union has repeatedly committed itself to increase the coherence of its external action, with Policy Coherence for Development being singled out as one of the most prominent cases. This paper investigates how the EU promotes this aim in the policy formulation of different governance areas. Using a historical institutionalist approach, it focuses on the process dimension of coherence by presenting extensive empirical data to analyse which institutional procedures – such as Commission inter-service consultations – are regularly applied to what effect. The study discusses the results of tracing the planning of six selected initiatives in fisheries, environment and security policy. It finds that the effective promotion of Policy Coherence for Development does not necessarily depend on the particular policy field and its degree of communitarisation as such but rather on the policy instrument used and especially on the EU institution which conducts the policy formulation.

Topic: European Union Policy and Governance
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Exudation of Allelopathic Substances in Buckwheat (<i>Fagopyrum esculentum</i> Moench)

Root exudates of the common buckwheat, especially phenolic compounds, were studied. Their contents, both in the soil during the growing season and in agar medium during germination, were determined by HPLC and GC-MS. The allelopathic activity of the soil from a buckwheat stand was evaluated, as well. Palmitic acid, squalene, epicatechin, vitexin, a gallic acid derivative, and a quercetin derivative were the main compounds of the agar medium. In the soil, palmitic acid methyl ester, vanillic acid, rutin, a gallic acid derivative, and a 4-hydroxyacetophenone derivative were identified. The effects of vitexin, squalene, epicatechin, 4-hydroxyacetophenone, and vanillic and gallic acids were tested on eight plant species. Inhibitive effects were observed in the cases of 4-hydroxyacetophenone and vanillic and gallic acids. Comparisons of the identified compounds and inhibitive effects of soil extracts indicated that palmitic acid and the gallic acid derivative probably have an important function in the allelopathic root response of buckwheat.

Topic: Allelopathy and phytotoxic interactions
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[A method of stable osteosynthesis in diaphyseal fractures of the femur].

The known methods of operative treatment of femur by means of intraosseous osteosynthesis, based on jamming of intraosseous structure in the bone, don't ensure sufficient level of the osteosynthesis stability that results in the secondary displacements. According to the method, proposed by the authors, a rod is introduced through the intercondylar fossa of the distal fractured fragment of femur (Imamaliyev, 1987) and is pierced through into the proximal fractured fragment of femur so that it perforates cortical layer of the bone in the region of greater trochanter with strong fixation in it. The structure is removed through the small incision in the area of the greater trochanter of femur. 35 patients have been operated according to this method. The remote results have been studied with 22 of them. Consolidation terms equal to 2.5-5 months. The secondary displacement has been noted with 4 patients with comminuted fractures.

Topic: Hip and Femur Fractures
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Implications of public debt on economic growth and development.

This paper takes an ambitious look at long-run economic growth and investigates the relationship between debt, investments and economic development in a European context. The novelty of the approach is that it includes public debt as an independent variable in the augmented Solow model. The analysis is based on fixed effects models on a panel consisting of 12 European countries, observed across more than 30 years (1980-2012). Various estimation and validity issues are raised, including endogeneity and reverse causality. The general findings of this research are that economic growth has a significant negative effect on public debt accumulation. As economic growth slows down it leads to an increase in the budget deficit through reduced public revenue, leading to new debt issuance. The specific analyses for Italy and Portugal show that they have been on an unsustainable path in the last decades, accompanied by huge fiscal deficits, negative net exports, and rising interest rates on their debt.

Topic: Fiscal Policy and Economic Growth
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule

The mechanism responsible for the decreased extra-renal CYP3A activity in chronic kidney disease (CKD) patients remains unknown. Using an animal model, we previously found that elevated levels of serum intact parathyroid hormone (iPTH) caused a reduced CYP3A activity. This retrospective observational study assessed the relationship between serum iPTH levels and the blood concentration or dosage of tacrolimus, a CYP3A substrate, after oral administration in kidney transplant patients. Thirty-four patients were enrolled who had kidney transplants between April 2014 and March 2016 and who had been administrated once- daily prolonged-release tacrolimus (Graceptor<sup>®</sup>, Astellas Pharm Inc.). Among the 34 patients, 22 had taken a CYP3A inhibitor. These patients were excluded from the study. A significant positive correlation between serum iPTH and tacrolimus trough levels was found at 4 d before kidney transplantation in 12 patients who were not receiving potent CYP3A inhibitor. In addition, serum iPTH levels before transplantation could serve as a factor for the dose of tacrolimus up to 1 year after transplantation. Monitoring serum iPTH levels could predict the trough level for the initial administration of tacrolimus, and may serve as an index for the initial dose of tacrolimus in kidney transplantation patients.

Topic: Renal Transplantation Outcomes and Treatments
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
PAMO University of Medical Sciences Admission form for 2022/2023 post utme form\\Tranfer

The management of PAMO University of Medical Sciences Post UTME Admission ☎️ (080)67046209 Prof FAITH Main Campus Candidates should have at least five (5) credit passes in the SSCE (WAEC/NECO) at one sitting, or six (6) credit passes at not more than 2 sittings in English Language, Mathematics and other subjects relevant to the course of study. Candidates are also to note that there are other requirements that may be specific to a College and/or a Programme

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Minnesota County Boundaries - lines

minnesota county boundaries derived from a combination of 1 24 000 scale pls lines 1 100 000 scale tiger 1 100 000 scale dlg and 1 24 000 scale hydrography lines at the time of its development 1993 the largest available scale data were assembled to create the layer

Topic: Botany, Ecology, and Taxonomy Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
<i>sucker</i> encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development

ABSTRACT Mutation of sucker (suc) disrupts development of the lower jaw and other ventral cartilages in pharyngeal segments of the zebrafish head. Our sequencing, cosegregation and rescue results indicate that suc encodes an Endothelin-1 (Et-1). Like mouse and chick Et-1, suc/et-1 is expressed in a central core of arch paraxial mesoderm and in arch epithelia, both surface ectoderm and pharyngeal endoderm, but not in skeletogenic neural crest. Long before chondrogenesis, suc/et-1 mutant embryos have severe defects in ventral arch neural crest expression of dHAND, dlx2, msxE, gsc, dlx3 and EphA3 in the anterior arches. Dorsal expression patterns are unaffected. Later in development, suc/et-1 mutant embryos display defects in mesodermal and endodermal tissues of the pharynx. Ventral premyogenic condensations fail to express myoD, which correlates with a ventral muscle defect. Further, expression of shh in endoderm of the first pharyngeal pouch fails to extend as far laterally as in wild types. We use mosaic analyses to show that suc/et-1 functions nonautonomously in neural crest cells, and is thus required in the environment of postmigratory neural crest cells to specify ventral arch fates. Our mosaic analyses further show that suc/et-1 nonautonomously functions in mesendoderm for ventral arch muscle formation. Collectively our results support a model for dorsoventral patterning of the gnathostome pharyngeal arches in which Et-1 in the environment of the postmigratory cranial neural crest specifies the lower jaw and other ventral arch fates.

Topic: Developmental Biology and Gene Regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supplemental Table 4 from Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA

&lt;p&gt;Summary of driver and resistance mutations in EGFR and ALK detected in ctDNA, tDNA, and both ctDNA and tDNA&lt;/p&gt;

Topic: Lung Cancer Treatments and Mutations
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Use of Lotteries for the Promotion of Voluntary Medical Male Circumcision Service: A Discrete-Choice Experiment among Adult Men in Tanzania

Voluntary medical male circumcision (VMMC) is effective in reducing the risk of human immunodeficiency virus (HIV). However, countries like Tanzania have high HIV prevalence but low uptake of VMMC. We conducted a discrete-choice experiment to evaluate the preferences for VMMC service attributes in a random sample of 325 men aged 18 years or older from the general population in 2 Tanzanian districts, Njombe and Tabora. We examined the preference for financial incentives in the form of a lottery ticket or receiving a guaranteed transport voucher for attendance at a VMMC service. We created a random-parameters logit model to account for individual preference heterogeneity and a latent class analysis model for identifying groups of men with similar preferences to test the hypothesis that men who reported sexually risky behaviors (i.e., multiple partners and any condomless sex in the past 12 months) may have a preference for participation in a lottery-based incentive. Most men preferred a transport voucher (84%) over a lottery ticket. We also found that offering a lottery-based financial incentive may not differentially attract those with greater sexual risk. Our study highlights the importance of gathering local data to understand preference heterogeneity, particularly regarding assumptions around risk behaviors.

Topic: Genital Health and Disease
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Creating Learner-Centered Learning Environments in 21st Century Higher Education Classrooms

Workforce capabilities are evolving into complexity and educational institutions are to adopt newstrategies complied with this change in order to help the students to survive in sophisticated workenvironments requiring not only mastery of the content knowledge but also problem solving skills.Our traditional model of higher education is not meeting the 21st century challenges. In order torespond the demands of the new era higher education institutions must revise their programs andpedagogies. In this article, the author discusses the ways of fulfilling the needs of twenty-first-centurylearners who are expected to solve novel and complex problems. In this respect technology is avaluable tool for making our graduates acquire the core 21st century capabilities. Creating learningenvironments enabling the students actively engaged in the learning process and making them activeteam members should be the utmost goal of higher education classrooms. Meaningful learningthrough technology enhanced learning environments can aid the learners to improve theiradaptability skills and succeed in real life situations. This paper emphasizing the importance ofconstructivist learning platforms will focus on good practices of Technology Enhanced ActiveLearning (TEAL) classrooms in higher education. Furthermore on the way of creating learner-centeredlearning environments, the challenges that will be faced by teachers, instructional designers, andeducational administrators will be discussed and the new roles of the instructors will be elaborated.

Topic: Online and Blended Learning
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Pre-service biology teachers’ knowledge of the 21st-century skills and its associated instructional models: The Indonesian context

Integrating the 21st-century skills into Indonesia’s education system is crucial for equipping students to face future challenges. This study investigates the knowledge of pre-service biology teachers in Indonesia regarding the 21st -century skills and their understanding of instructional models that support skill development. Conducted from March to September 2024, the research employed a cross-sectional survey design with a total sampling technique, involving 78 students from a Biology Education program at a public Islamic university in North Sumatra, all of whom had completed a course on biology learning strategies. Data were gathered using questionnaires and analyzed quantitatively to determine key trends. The findings indicate that although most students recognize the significance of the 21st-century skills in biology education, their understanding is limited. Only a small number could identify all essential skills, with creative thinking being the most recognized. Students were well-acquainted with project-based learning as a model for developing these skills but had limited knowledge of the structure and application of other instructional models, such as discovery and inquiry learning. These findings emphasize the need for curriculum improvement to deepen students’ comprehension of various instructional models and the integration of diverse information sources, enabling more effective integration of the 21st -century skills into biology education.

Topic: Genetics, Bioinformatics, and Biomedical Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Effect of Overseas Export Factors of ICT Companies on Non-Financial Performance

본 연구는 ICT 수출기업을 대상으로 하여 수출성과에 미치는 영향요인들을 실증적으로 분석하고자 하는데 그 목적이 있었다. 연구모형은 선행연구에서 논의되었던 변수들을 중심으로 하여 수출성과에 미치는 요인들을 크게 기업특성 요인, 마케팅 특성요인, 수출지원제도 특성요인 등 3개의 변수로 설정하였고, 종속변수로 수출성과를 비 재무적 성과로 설정하여 분석하였다. 분석 결과, 수출성과에 영향을 미치는 변수 중 기업특성 요인(CEO 시장 지향성, 수출경쟁력, 수출경험)과 마케팅 특성요인(해외 시장 다변화, 마케팅 애로 요인)은 수출 성과로 설정한 비 재무적 성과에 영향을 미치는 변수임을 알 수 있었다. 그러나 수출지원제도 특성 요인은 비 재무적 성과에 영향을 미치지 않는 변수임을 알 수 있었다. In this study, I empirically analyzed the factors affecting export performance with domestic ICT companies. I set up 3 variables - companies' factors, marketing factors and factors of export supporting system - as the factors affecting export performance, based on findings of precedent studies; and I set up non-financial performance as a dependent variable. As a result of analysis, I found out that companies' factors(market orientation of CEO, competitiveness in export, experience of export) and marketing factors(diversification of overseas market, barriers to marketing), among the variables affecting export performance, were the variables affecting non-financial performance, set up as the export performance; but the factors of awareness, availability and difficulty, set up as the detail factor among factors of export supporting system, do not affect non-financial performance.

Topic: International Business and FDI
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Expression in <i>Escherichia coli</i>, purification and characterization of heparinase I from <i>Flavobacterium heparinum</i>

The use of heparin for extracorporeal therapies has been problematical due to haemorrhagic complications; as a consequence, heparinase I from Flavobacterium heparinum is used for the determination of plasma heparin and for elimination of heparin from circulation. Here we report the expression of recombinant heparinase I in Escherichia coli, purification to homogeneity and characterization of the purified enzyme. Heparinase I was expressed with an N-terminal histidine tag. The enzyme was insoluble and inactive, but could be refolded, and was purified to homogeneity by nickel-chelate chromatography. The cumulative yield was 43%, and the recovery of purified heparinase I was 14.4 mg/l of culture. The N-terminal sequence and the molecular mass as analysed by matrix-assisted laser desorption MS were consistent with predictions from the heparinase I gene structure. The reverse-phase HPLC profile of the tryptic digest, the Michaelis–Menten constant Km (47 μg/ml) and the specific activity (117 units/mg) of purified recombinant heparinase I were similar to those of the native enzyme. Degradation of heparin by heparinase I results in a characteristic product distribution, which is different from those obtained by degradation with heparinase II or III from F. heparinum. We developed a rapid anion-exchange HPLC method to separate the products of enzymic heparin degradation, using POROS perfusion chromatography media. Separation of characteristic di-, tetra- and hexa-saccharide products is performed in 10 min. These methods for the expression, purification and analysis of recombinant heparinase I may facilitate further development of heparinase I-based medical therapies as well as further investigation of the structures of heparin and heparan sulphate and their role in the extracellular matrix.

Topic: Proteoglycans and glycosaminoglycans research
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
XUV Frequency Combs via Femtosecond Enhancement Cavities

We review the current state of tabletop extreme ultraviolet (XUV) sources based on high harmonic generation (HHG) in femtosecond enhancement cavities (fsEC). Recent developments have enabled generation of high photon flux (1014 photons/sec) in the XUV, at high repetition rates (&gt;50 MHz) and spanning the spectral region from 40 nm - 120 nm. This level of performance has enabled precision spectroscopy with XUV frequency combs and promises further applications in XUV spectroscopic and photoemission studies. We discuss the theory of operation and experimental details of the fsEC and XUV generation based on HHG, including current technical challenges to increasing the photon flux and maximum photon energy produced by this type of system. Current and future applications for these sources are also discussed.

Topic: Advanced Fiber Laser Technologies
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Influence of Meso- and Microclimatic Conditions on the CO2 Emission from Soils of the Urban Green Infrastructure of the Moscow Metropolis

Against the background of global warming, urban ecosystems are becoming increasingly vulnerable to climate stresses. Strategies for climate adaptation developed for almost every major city in the world pay considerable attention to urban green infrastructure as a nature-oriented solution for carbon sequestration. However, the influence of urban climate on the spatiotemporal variability of CO2 emissions from urban soils remains poorly understood, which can lead to inaccurate estimates and inflated expectations of urban green infrastructure in the context of carbon neutrality. In 2019–2022, studies of the dynamics of CO2 emission with parallel monitoring of soil temperature and soil moisture were carried out at three green infrastructure sites of Moscow differing in their mesoclimatic conditions. For each object, plots with different types of vegetation were compared, which made it possible to assess the internal heterogeneity of soil and microclimatic conditions. Soil temperature determined up to 70% of the total variance of CO2 emissions. Mean annual soil temperature in the city center was almost 3–6°C higher than that in the peripheral areas (10–12 km from the center), whereas soil moisture in the center was 10–15% lower. Soils under lawns and shrubs were, on average, 1–2°C warmer and 10–15% wetter than soils under trees. The annual CO2 emission from soils under lawns was, on average, 20–30% higher than that from soils under tree plantations in the same area. At the same time, the differences between the plots with the same vegetation in the center and on the periphery reached 50%, which reflects the high vulnerability of urban soil carbon stocks to mesoclimatic anomalies and the high risks of a further increase in CO2 emissions from urban soils against the background of climate change.

Topic: Urban Heat Island Mitigation
Subfield: Environmental Engineering
Field: Environmental Science
Domain: Physical Sciences