jimnoneill/paper-to-field-training huggingface dataset:
Daclizumab-Associated Erythroderma Is Associated with Rebound Increases in CD25-Positive CD4 Cells Following Treatment of Aplastic Anemia and Pure Red Cell Aplasia.

Abstract We previously have reported success in treating patients with moderate aplastic anemia with daclizumab, a humanized monoclonal antibody that recognizes the interleukin-2 receptor (Blood.2003; 102(10):3584–6). Since our first report we have treated eighty-eight patients with moderate aplastic anemia, pure red cell aplasia and relapsed severe aplastic anemia with 1 mg/kg of monoclonal antibody every 2 weeks for 3 months. Although this drug has been used extensively in the management of solid organ rejection, erythroderma has not been reported. In our study, five patients developed a severe generalized erythema in a period of 20 to 70 days following the last dose of treatment. The cutaneous eruptions were characterized by severe pruritis and intense erythematous inflammation with spongiotic papules and plaques. Pathologic evaluation was possible for four of five patients and described focal spongiosis, dermal lymphocytic infiltration including some eosinophils, and no evidence of infection. All patients were negative for anti-nuclear antibody and had no arthritis, fever, or other systemic signs. HLA types were available on 83 of the 88 patients. HLA DR13 was more common in the patients that developed a rash; 80% versus 18% in those who did not develop rash (p = .0071, Fisher’s Exact Test). The rash was associated with a two to ten fold increase in the proportion of CD25-positive CD4 cells compared to pre-drug levels (p&amp;lt;0.05). All patients required treatment with oral corticosteroids for periods of 2–6 weeks. Three patients who had partial or minimal responses to daclizumab elected to undergo a second course. The three patients who had a mild rash after the first course of treatment developed a more severe eruption with subsequent administration of the drug; rashes were delayed after each therapeutic administration of daclizumab. Two additional patients developed other autoimmune symptoms including inflammatory arthritis about three months following daclizumab administration. The absence of autoimmune complications following use of daclizumab in solid organ or allogeneic stem cell transplant recipients may be related to additional immunosuppression frequently administered to these patients. Our working hypothesis is that daclizumab associated rash is caused by an immune phenomenon. This is supported by the findings that CD4+CD25+ (effector) T cells are expanded at the time of the rash, the presence of a lymphocytic dermal infiltrate, and the relative preponderance of HLA-DR13 in the affected group. It is possible that treatment with daclizumab (an anti-CD25 antibody) results in a relative depletion of CD4+CD25+ regulatory T cells thereby permitting expansion of CD4+CD25+ effector T cells.

Topic: Autoimmune Bullous Skin Diseases
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Writing and checking complete proofs in T E X

TEX files are text files which are readable by other programs. Mathematical proofs written using TEX can be checked by a Python program provided they are expressed in a sufficiently strict proof language. Such a language can be constructed using only a few extensions beyond the syntax of A.P. Morse’s A Theory of Sets, one being the incorporation of explicit theorem number references into the syntax. Such a program has been applied to and successfully checked the theorems in a significant initial segment of a book length mathematical manuscript. 1

Topic: Mathematics, Computing, and Information Processing
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
A Lightweight Deep Learning Model for Tea Leaf Disease Identification

Tea is a globally important economic crop, and the ability to quickly and accurately identify tea leaf diseases can significantly improve both the yield and quality of tea production. With advances in deep learning, many recent studies have demonstrated that convolutional neural networks are both feasible and effective for identifying tea leaf diseases. In this paper, we propose a modified EfficientNetB0 lightweight convolutional neural network, enhanced with the ECA module, to reliably identify various tea leaf diseases. We used two tea leaf disease datasets from the Kaggle platform: the Tea_Leaf_Disease dataset, which contains six categories, and the teaLeafBD dataset, which includes seven categories. Experimental results show that our method substantially reduces computational costs, the number of parameters, and overall model size. Additionally, it achieves accuracies of 99.49% and 90.73% on these widely used datasets, making it highly suitable for practical deployment on resource-constrained edge devices.

Topic: Smart Agriculture and AI
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Hepatocarcinogenic Susceptibility of Fenofibrate and Its Possible Mechanism of Carcinogenicity in a Two-Stage Hepatocarcinogenesis Model of rasH2 Mice

Fenofibrate (FF) has previously been shown to induce hepatocellular neoplasia in a conventional mouse bioassay (NDA 1993), but there has been no report to examine the carcinogenic susceptibility of rasH2 mice to this chemical. In the present study, male rasH2 mice were subjected to a two-thirds partial hepatectomy (PH), followed by an N-diethylnitrosamine (DEN) initiation twenty-four hours after PH, and given a diet containing 0, 1200, or 2400 ppm FF for seven weeks. The incidences of preneoplastic foci were significantly increased in mice from the FF-treated groups. Immunohistochemistry revealed that significant increases in proliferating cell nuclear antigen (PCNA)-positive cells and cytokeratin 8/18 positive foci were observed in FF-treated groups. In addition, the transgene and several downstream molecules such as c- myc, c- jun, activating transcription factor 3 (ATF3), and cyclin D1 were overexpressed in these groups. These results suggest that the hepatocarcinogenic activity of rasH2 mice to FF can be detected in this hepatocarcinogenesis model and that up-regulation of genes for the ras/MAPK pathway and cell cycle was probably involved in the hepatocarcinogenic mechanism of rasH2 mice.

Topic: Chronic Myeloid Leukemia Treatments
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Moisture and Bio-deterioration Risk of Building Materials and Structures

There are several biological processes causing aging and damage to buildings. This is partly due to natural aging of materials and excessive moisture. The demands on durability, energy balance, and health of houses are continually rising. For mold development, the minimum (critical) ambient humidity requirement is shown to be between RH 80% and 95% depending on other factors like ambient temperature, exposure time, and the type and surface conditions of building materials. For decay development, the critical humidity is above RH 95%. Mold typically affects the quality of the adjacent air space with volatile compounds and spores. The next stage of moisture-induced damage, the decay development, forms a serious risk for structural strength depending on moisture content, materials, temperature, and time. The worst decay damage cases in North Europe are found in the floors and lower parts of walls, where water accumulates due to different reasons. Modeling of mold growth and decay development based on humidity, temperature, exposure time, and material will give new tools for the evaluation of durability of different building materials and structures. The models make it possible to evaluate the risk and development of mold growth and to analyze the critical conditions needed for the start of biological growth. The model is also a tool to simulate the progress of mold and decay development under different conditions on the structure surfaces. This requires that the moisture capacity and moisture transport properties in the material and at the surface layer be taken into account in the simulations. In practice there are even more parameters affecting mold growth, e.g., thickness of the material layers combined with the local surface heat and mass transfer coefficients. Therefore, the outcome of the simulations and in situ observations of biological deterioration may not agree. In the present article, results on mold growth in different materials and wall assemblies will be shown and existing models on the risk of mold growth development will be evaluated. One of the results of a newly finished large Finnish research project ‘modeling of mold growth’ is an improved and extended mathematical model for mold growth. This model and more detailed research results will be published in other papers.

Topic: Building materials and conservation
Subfield: Earth-Surface Processes
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Analysis of ATF6 Activation in Site-2 Protease-deficient Chinese Hamster Ovary Cells

Mammalian transcription factor ATF6 is constitutively synthesized as a type II transmembrane protein embedded in the endoplasmic reticulum (ER). It is activated when unfolded proteins are accumulated in the ER under ER stress through a process called regulated intramembrane proteolysis (Rip), in which ATF6 is transported from the ER to the Golgi apparatus where it undergoes sequential cleavage by Site-1 and Site-2 proteases. The cytosolic transcription factor domain of ATF6 liberated from the Golgi membrane enters the nucleus where it activates transcription of ER-localized molecular chaperones and folding enzymes, leading to the maintenance of the homeostasis of the ER. Here, we analyzed M19 cells, a mutant of Chinese hamster ovary cells deficient in Site-2 protease. It was previously shown that M19 cells are defective in the induction of mRNA encoding the major ER chaperone BiP. In M19 cells, ATF6 was not converted from the membrane-bound precursor form to the cleaved and nuclear form as expected. Moreover, some of the ATF6 was constitutively relocated to the Golgi apparatus, where it was cleaved by Site-1 protease, and remained associated with the Golgi apparatus, indicating that the ER of M19 cells was constitutively stressed. Consistent with this notion, the two other ER stress response mediators, IRE1 and PERK, were also constitutively activated in M19 cells. M19 cells showed inefficient secretion of a model protein. These results suggest that Rip-mediated activation of ATF6 is important for the homeostasis of the ER in not only ER-stressed but also unstressed cells.

Topic: Endoplasmic Reticulum Stress and Disease
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Impact of working capital on the profitability of South African firms listed on the Johannesburg Stock Exchange

This study examines the influence of working capital management components on the profitability of South African firms listed on the Johannesburg Stock Exchange (“JSE”). In addition, the study investigates how the influence of the selected working capital management components changes as macroeconomic conditions change. The study used accounting based secondary data obtained from I-Net Bridge and BF McGregor for 254 firms from 2004 to 2010. The Pooled Ordinary Least Squares (“OLS”) regression models were used in the analyses. The key findings from the study indicate the following: (1) that there exists a significant negative relationship between the net time interval between actual cash expenditures on a firm‟s purchase of productive resources and the ultimate recovery of cash receipts from product sales (cash conversion cycle) and profitability. This negative relationship suggests that managers can create value for the shareholders of the firm by reducing the cash conversion cycle; (2) that there exists a significant negative relationship between days sales in receivables and profitability. This indicates that slow collection of accounts receivables is associated with low profitability and suggests that corporate managers can improve profitability by reducing credit period granted to their customers; (3) that an increase in the length of a firm‟s cash (operating) cycle tends to increase profitability during an economic recession than during an economic boom. This result indicates that firms adopt a more generous trade credit policy during an economic recession than during a boom in an attempt to boost sales which would ordinarily dwindle during a recession. The implication of this positive relationship in comparison with a negative relationship between the normal cash conversion cycle and profitability is that corporate managers need to streamline their trade credit policy and change it accordingly as the macroeconomic environment changes in ensuring that the company‟s sales are not adversely impacted as economic conditions change.&#13;\nFurthermore, the study finds that there exists a highly significant negative relationship between profitability and the following respective ratios: days payables outstanding, current ratio, and capital structure. The negative relationship found between profitability and debt to equity ratio (used as a proxy for capital structure) indicates that South African firms‟ profitability tends to decrease at excessively high and increasing levels of debt.

Topic: Working Capital and Financial Performance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Local and broadcast clock synchronization in a sensor node

Energy constrained wireless sensor networks need to maintain network timing for coordinating event detection and processing, and to enable receiver duty cycling and communications rendezvous, in order to save energy. Motivated by this, we consider synchronization of a slow low-power local oscillator with an occasionally observed fast and highly accurate broadcast clock (such as GPS). Errors are modeled as quantization noise, incurred when comparing the slow and fast clocks. We consider estimation of the offset and skew between the clocks, detection of drift in the local clock, and prediction of the broadcast clock based on the locally observed times.

Topic: Network Time Synchronization Technologies
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Nonparametric Heterogeneity Testing For Massive Data

A massive dataset often consists of a growing number of (potentially) heterogeneous sub-populations. This paper is concerned about testing various forms of heterogeneity arising from massive data. In a general nonparametric framework, a set of testing procedures are designed to accommodate a growing number of sub-populations, denoted as $s$, with computational feasibility. In theory, their null limit distributions are derived as being nearly Chi-square with diverging degrees of freedom as long as $s$ does not grow too fast. Interestingly, we find that a lower bound on $s$ needs to be set for obtaining a sufficiently powerful testing result, so-called "blessing of aggregation." As a by-produc, a type of homogeneity testing is also proposed with a test statistic being aggregated over all sub-populations. Numerical results are presented to support our theory.

Topic: Statistical Methods and Inference
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Intraoperative uterine packing with mops: an effective, but under utilized method of controlling post partum haemorrhage-experience from South Eastern Nigeria.

In carefully selected cases, intraoperative uterine packing is a simple and effective life saving option in our local environment with peculiar beliefs, lack of equipment and expertise.

Topic: Maternal and fetal healthcare
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Neutrosophic Soft Sets And Neutrosophic Soft Matrices Based On Decision Making

Maji[, firstly proposed neutrosophic soft sets can handle the indeterminate information and inconsistent information which exists commonly in belief systems. In this paper, we have firstly redefined complement, union and compared our definitions of neutrosophic soft with the definitions given by Maji. Then, we have introduced the concept of neutrosophic soft matrix and their operators which are more functional to make theoretical studies in the neutrosophic soft set theory. The matrix is useful for storing an neutrosophic<br> soft set in computer memory which are very useful and applicable. Finally, based on some of these matrix operations a efficient methodology named as NSM-decision making has been developed to solve neutrosophic soft set based group decision making problems.

Topic: Fuzzy and Soft Set Theory
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Are Collections Scholarly Outputs? Re-defining Research Quality and Impact of Cultural Performative Findings

The paper explores user-centred cultural heritage collections which are rooted in community life and scholarship, and searches for new terminology and rationale to define them as research outputs first by examining notions of content and quality according to current ARC definitions and ERA categories of research outputs. Considering the performative paradigm as an opportunity to re-define knowledge that is not numerically or textually encoded but contains performative signs incorporated into captured cultural records through audio and/or audiovisual mediums, the paper proposes that the performative paradigm allows scholars to view performative signs not as mere data or by-products of their research but as a wealth of performative evidence that complements quantitative and/or qualitative methodologies and therefore is an integral part of their scholarly outputs. This implies the need for consolidation of the close collaborative processes between scholars, community members and information professionals, and further development of databases such as PARADISEC and AusLit to enhance discovery, description and citation of audio-visual materials while at the same time hosting hybrid online journals that publish text-based exegeses with the capacity to link to specific portions of cultural heritage content. Lastly, the paper discusses the assessment and measurement of research impact which will be the new focus of government assessment exercises, highlighting the advantage of cultural heritage knowledge banks due to their digital accessibility and potential for a variety of citation statistics that enable assessment of both quality and impact.

Topic: Digital and Traditional Archives Management
Subfield: Conservation
Field: Arts and Humanities
Domain: Social Sciences
Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts

The present study was designed to evaluate the ability of allopurinol to limit infarct size following permanent coronary occlusion in the greyhound. Coronary occlusion was produced by injecting 2.5 mm plastic beads into the coronary artery of the closed chest dog. Non-perfused myocardium, the area at risk, was visualised by autoradiography of 141Cerium labelled microspheres which were infused immediately following coronary embolization. The treated dogs (n = 12) received 400 mg of allopurinol orally one day before surgery. A 25 mg . kg-1 bolus was administered (iv) immediately before occlusion, and repeated every 8 h. 11 dogs served as controls. After 24 h, the dogs were killed and the hearts were sliced into 5.0 mm transverse sections. The infarcted myocardium was visualised by triphenyl tetrazolium chloride staining. The percentage of the risk zone which evolved to infarct was calculated. This percentage was 18.1 +/- 3.95% in the allopurinol group vs 58.4 +/- 2.81% in the control group (p less than 0.001). We conclude that allopurinol is a potent drug for the limitation of infarct size in the dog with permanent coronary occlusion.

Topic: Cardiac Imaging and Diagnostics
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Essential Oil Compositions of Subspecies of Scutellaria Brevibracteata Stapf from Turkey

Scutellaria L., with nearly 400 species, is one of the largest genera of the family Lamiaceae. In the last taxonomic treatment conducted by the first author, the genus Scutellaria has been evaluated as a genus with 33 taxa consisting of 25 species, 1 hybrid species and 13 subspecies in the Flora of Turkey. Turkish Scutellaria species are classified under three sections: section Scutellaria, section Salviifoliae and section Lupulinaria. We have here studied essential oil composition of the subspecies of S. brevibracteata belonging to the section Scutellaria. In the Anatolian traditional medicine, there is no more information on usage of Scutellaria except for the usage for constipation, hemostatic, tonic and wound healing, due to lack of its aromatic odour.Dried the aerial parts of three subspecies of Scutellaria brevibracteata Stapf from Turkey were hydrodistilled. The chemical compositions of the essential oils obtained by hydrodistillation were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), simultaneously. The subspecies of S. brevibracteata investigated here as follows: S. brevibractetata Stapf subsp. brevibracteata, S. brevibractetata Stapf subsp. subvelutina (Rech.f.) Greuter &amp;amp;amp; Burdet and S. brevibractetata Stapf subsp. pannosula (Rech.f.) Greuter &amp;amp;amp; Burdet.According to the results of analyzing, β-caryophyllene (22.8%) and caryophyllene oxide (16.0%) were determined as the main components in S. brevibractetata subsp. brevibracteata oil. In S. brevibractetata subsp. subvelutina oil, β-caryophyllene (28.3%), linalool (12.4%), hexadecanoic acid (10.8%) were found as major constituents. β-caryophyllene (36.4%), a-cadinol (9.8%), d-cadinene (7.0%) linalool (5.3%) were identified as major component in the oils of S. brevibractetata subsp. pannosula.

Topic: Flavonoids in Medical Research
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Automatic Detection of Multiple Trapped Victims by Ultra-Wideband Radar

Via analyzing the characteristics of life sign, a novel method is proposed to detect multiple trapped victims by ultra-wideband radar in this letter. The signal-to-noise and clutter ratio (SNCR) is greatly improved. The non-static clutter can be removed effectively. The number, range position and respiratory frequency of life signs can be detected automatically and accurately in low SNCR environment. By using experiment and numerical simulation, the good performance of the new method is proved.

Topic: Advanced SAR Imaging Techniques
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
CCDC 807706: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences