jimnoneill/paper-to-field-training huggingface dataset:
Late recovery of sinus rhythm following perioperative complete atrioventricular block in a child with congenitally corrected transposition

We report a patient with l-transposition of the great arteries who developed perioperative complete atrioventricular block at 5 years of age in conjunction with a modified double-switch operation, but had unexpected late recovery of normal sinus rhythm months later. This case highlights that even for patients with l-transposition, which is particularly vulnerable to developing both spontaneous and perioperative complete atrioventricular block, late recovery of atrioventricular node conduction may still be possible after surgery.

Topic: Cardiac pacing and defibrillation studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Human recombinant interferon alpha-2C enhances the expression of class II HLA antigens on hairy cells

Abstract Isolated splenic hairy cells from three untreated patients were cultured in presence of recombinant human interferon alpha-2C (IFN alpha). Ultrastructural cytochemistry and immunophenotype analysis with a large panel of monoclonal antibodies were performed to study cellular modification induced by IFN alpha. Hairy cells showed a typical pheno- type: Smlg+, B1+, BA1+/-, anti-Tac+, OKDR+, Leu-M5+, HC2+, TRAP+, myeloperoxidase-. Under our experimental conditions, we found no direct cytotoxic effects or significant variations in morphology, cytochemistry, and percentage of reactivity with the tested monoclonal antibodies. After culturing in the presence of different doses of IFN alpha, we observed a significant enhancement of the expression of class II HLA antigens as demonstrated by increased fluorescence for OKDR, OKla, Leu-10 at fluorescence-activated cell sorting analysis. In agreement with this finding IFN alpha-treated hairy cells showed an increased stimulatory capacity v allogeneic T cells in one-way mixed lymphocyte reaction. To our knowledge this is the first report describing the induction of class II HLA antigens on hairy cells by IFN alpha.

Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
A decision model for selecting of areas for improvement in EFQM model

To monitor the progress towards business excellence, thousands of organizations across the world use self-assessment on a regular basis. There are a few popular business excellence models that provide standard criteria against which an organization can measure its performances. European Foundation for Quality Management (EFQM) is the most popular ones. The EFQM Excellence Model was introduced at the beginning of 1992 as the framework for assessing organizations for the European Quality Award. It is now the most widely used organizational framework in Europe and across the world and it has become the basis for the majority of international, national and regional Quality Awards. It is a practical tool that can be used as a guide to identify areas for Improvement. However, the current EFQM model has some drawbacks and problems which are not able to identify the priorities in Area for Improvement (AFI). For organizations with limitations of time, budget and resources and cannot implement all the Area for Improvement, some standards or indexes and limitations should be defined for prioritizing and choosing the Area for Improvement. Using Topsis <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> method which is one of the multi-attribute decision making model, the Area for Improvement can be identified. Therefore, this work will develop a method of evaluating, assessing and determining the Area for Improvement in the EFQM model. The results showed that the developed model is more valid and acceptable and the experts verified the model for selecting of Area for Improvement in EFQM in practice. The proposed model was employed in a case study and drawn out results from it and were evaluated from different points of view.

Topic: Quality and Supply Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Comment on essd-2022-273

<strong class="journal-contentHeaderColor">Abstract.</strong> Rice is the most important staple food in Asia. However, high-spatiotemporal-resolution rice yield datasets are limited over this large region. The lack of such products greatly hinders studies that are aimed at accurately assessing the impacts of climate change and simulating agricultural production. Based on annual rice maps in Asia, we incorporated multisource predictors into three machine learning (ML) models to generate a high-spatial-resolution (4âkm) seasonal rice yield dataset (AsiaRiceYield4km) for the 1995â2015 period. Predictors were divided into four categories that considered the most comprehensive rice growth conditions, and the optimal ML model was determined based on an inverse probability weighting method. The results showed that AsiaRiceYield4km achieves good accuracy for seasonal rice yield estimation (single rice: <span class="inline-formula"><i>R</i><sup>2</sup>=0.88</span>, RMSEâ<span class="inline-formula">=</span>â920âkgâha<span class="inline-formula"><sup>â1</sup></span>; double rice: <span class="inline-formula"><i>R</i><sup>2</sup>=0.91</span>, RMSEâ<span class="inline-formula">=</span>â554âkgâha<span class="inline-formula"><sup>â1</sup></span>; and triple rice: <span class="inline-formula"><i>R</i><sup>2</sup>=0.93</span>, RMSEâ<span class="inline-formula">=</span>â588âkgâha<span class="inline-formula"><sup>â1</sup></span>). Compared with single rice from the Spatial Production Allocation Model (SPAM), the <span class="inline-formula"><i>R</i><sup>2</sup></span> of AsiaRiceYield4km was improved by 0.20, and the RMSE was reduced by 618âkgâha<span class="inline-formula"><sup>â1</sup></span> on average. In particular, constant environmental conditions, including longitude, latitude, elevation and soil properties, contributed the most (<span class="inline-formula">â¼</span>â45â%) to rice yield estimation. For different rice growth periods, we found that the predictors of the reproductive period had greater impacts on rice yield prediction than those of the vegetative period and the whole growing period. AsiaRiceYield4km is a novel long-term gridded rice yield dataset that can fill the unavailability of high-spatial-resolution seasonal yield products across major rice production areas and promote more relevant studies on agricultural sustainability worldwide. AsiaRiceYield4km can be downloaded from the following open-access data repository: <span class="uri">https://doi.org/10.5281/zenodo.6901968</span> (Wu et al., 2022).

Topic: Remote Sensing in Agriculture
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Molecular beacons in biomedical detection and clinical diagnosis.

Among the diverse nucleic acid probes, molecular beacons (MBs) have shown their excellent potential in a variety of basic researches and practical applications. Their excellent selectivity, sensitivity, and detection without separation have led them to be particularly useful in real-time intracellular monitoring of gene expression, development of biosensors, and clinical diagnostics. This paper will focus on the properties of various MBs and discuss their potential applications.

Topic: Advanced biosensing and bioanalysis techniques
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Inducible Nitric Oxide Synthase Mediates Retinal Apoptosis in Ischemic Proliferative Retinopathy

Ischemic proliferative retinopathy (e.g., diabetes mellitus, retinopathy of prematurity, or retinal vein occlusion) is a major cause of blindness worldwide. Apart from neovascularization, ischemic proliferative retinopathy leads to retinal degeneration. Apoptosis has been ascribed to be the leading mechanism in ischemic retinal degeneration. We showed recently that inducible nitric oxide synthase (iNOS) is expressed in the avascular retina in proliferative retinopathy in vivo and that iNOS expression in retinal glial cells is responsible for retinal neuronal cell death in vitro . Here we show that retinal apoptosis and subsequent degeneration occur in the murine model of ischemic proliferative retinopathy. Furthermore, because NO can have beneficial or detrimental effects in the retina, we analyzed the role of iNOS on retinal apoptosis in ischemic proliferative retinopathy. Using iNOS knock-out mice and iNOS inhibitor 1400W, we demonstrate in vivo that iNOS expression induces apoptosis locally in the inner nuclear layer of the avascular retina and that protein nitration may be involved in this process. These findings are the first evidence for retinal apoptosis in an animal model of ischemic proliferative retinopathy, demonstrating that iNOS plays a crucial role not only in retinal neovascular disease but also in retinal degeneration. We show that it is an ideal target to protect the hypoxic retina from degeneration and to improve its vascularization.

Topic: Nitric Oxide and Endothelin Effects
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study

BACKGROUND An increasing number of studies have begun to discuss the relationship between gut microbiota and diseases, yet there is currently a lack of corresponding articles describing the association between gut microbiota and hepatocellular carcinoma (HCC) and biliary tract cancer (BTC). This study aims to explore the relationship between them using Mendelian randomization (MR) analysis method. AIM To assess the relationship between gut microbiota and HCC and BTC. METHODS We obtained Genome-wide association study (GWAS) data for the gut microbiome from the intestinal microbiota genomic library (MiBioGen, https://mibiogen.gcc.rug.nl/ ). Additionally, we accessed data pertaining to HCC and BTC from the IEU open GWAS platform (https://gwas.mrcieu.ac.uk/ ). Our analysis employed fundamental instrumental variable analysis methods, including inverse-variance weighted, MR and Egger. To ensure the dependability of the results, we subjected the results to tests for multiple biases and heterogeneity. RESULTS During our investigation, we discovered 11 gut microbiota linked to an increased risk to BTC and HCC. The former included the genus Eubacterium hallii group (P = 0.017), Candidatus Soleaferrea (P = 0.034), Flavonifractor (P = 0.021), Lachnospiraceae FCS020 (P = 0.034), the order Victivallales (P = 0.018), and the class Lentisphaeria (P = 0.0.18). The latter included the genus Desulfovibrio (P = 0.042), Oscillibacter (P = 0.023), the family Coriobacteriaceae (P = 0.048), the order Coriobacteriales (P = 0.048), and the class Coriobacteriia (P = 0.048). Furthermore, in BTC, we observed 2 protective gut microbiota namely the genus Dorea (P = 0.041) and Lachnospiraceae ND3007 group (P = 0.045). All results showed no evidence of multiplicity or heterogeneity. CONCLUSION This study explores a causal link between gut microbiota and HCC and BTC. These insights may enhance the mechanistic knowledge of microbiota-related HCC and BTC pathways, potentially informing therapeutic strategies.

Topic: Gut microbiota and health
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
MINI-REVIEW Effects of calorie restriction on life span of microorganisms

as budding and fission yeasts has a robust and welldocumented impact on longevity. In order to efficiently utilize the limited energy during CR, these organisms shift from primarily fermentative metabolism to mitochondrial respiration. Respiration activates certain conserved longevity factors such as sirtuins and is associated with widespread physiological changes that contribute to increased survival. However, the importance of respiration during CR-mediated longevity has remained controversial. The emergence of several novel metabolically distinct microbial models for longevity has enabled CR to be studied from new perspectives. The majority of CR and life span studies have been conducted in the primarily fermentative Crabtree-positive yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, but studies in primarily respiratory Crabtree-negative yeast and obligate aerobes can offer complementary insight into the more complex mammalian response to CR. Not only are microorganisms helping characterize a conserved cellular mechanism for CR-mediated longevity, but they can also directly impact mammalian metabolism as part of the natural gut flora. Here, we discuss the contributions of microorganisms to our knowledge of CR and longevity at the level of both the cell and the organism.

Topic: Genetics, Aging, and Longevity in Model Organisms
Subfield: Aging
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Public Health Community Platform: Implementing Electronic Case Reporting

The Public Health Community Platform (PHCP) is currently piloting an initial implementation of an electronic case reporting (eCR) solution. This work integrates community-defined resources (such as the Reportable Conditions Knowledge Management System and the Reportable Conditions Trigger Codes) to extract standardized data from clinical EHRs and transport that data to the correct public health agency, automating a core function of public health surveillance. This eCR solution will allow public health to benefit from a centrally developed and deployed infrastructure and tools and decrease the burden for clinical provider participation.

Topic: Electronic Health Records Systems
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Predictors of hypertension detection in English general practices: a cross sectional study

Abstract Background Worldwide, high systolic blood pressure is the leading risk factor for deaths and disability-adjusted life-years but has been historically under-detected. This study aimed to quantify differences between estimated and practice-detected prevalences of hypertension across English general practices, and to determine how variations in detected prevalence could be explained by population-level and service-level factors. Methods Descriptive statistics, pair wise correlations between the independent variables and a multivariable regression analysis were undertaken. In the regression model, the outcome was detected hypertension prevalence, adjusted for estimated prevalence, person-related and disease-related determinants of illness and characteristics of general practices. Results Detected prevalence was substantially lower than estimated prevalence (mean difference 16.23%; standard deviation 2.88%). Higher detected prevalence was associated with increased deprivation, increased non-white ethnicity and urban location. Lower detected prevalence was associated with larger list sizes, more general practitioners and being located in the South outside London. The final multivariable model’s adjusted R2 value was 0.75. Conclusions Substantial under-detection of hypertension is widespread across England. Independent of estimated prevalence, factors associated with greater morbidity and population density predicted higher detected prevalence. Identifying patients with undetected hypertension and coordinating care for these patients will require further resources and logistical support in community settings.

Topic: Global Health Care Issues
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Acromegaly Following Gigantism: Report of Case Treated by X-ray

ACROMEGALY was first accurately described, and was named, by Marie in 1886. It is a condition occurring in adult life, characterized by enlargement of the "acra," i. e., the hands, feet, lower jaw, nose and lips. Typically, the skeletal changes consist in enlargement, with tufting, of the terminal phalanges of the fingers and toes, enlargement of the bones, as well as the soft tissues, of the hands and feet, overgrowth of the inferior maxilla with progressive malocclusion of the teeth, and increasing prominence of the frontal region, with great enlargement of the frontal sinuses. It is stated (Bassoe) that the bone changes are secondary to changes in the soft parts, and are, indeed, caused by these soft-tissue changes. Cushing gives four views as to the causation of acromegaly. The first is Marie's conception of it as a general dystrophy, although he later believed it to be caused by a diminished hypophyseal function. The second is that it is due to an eosinophilic hyperplasia of the pituitary, with or without enlargement, producing hyperfunction. This is the view of Benda, Lewis and Erdheim. The third conception is that the changes are due to an underlying nutritional disorder, the hypophyseal enlargement being secondary and not primary. The fourth view is similar to the third, in that it assumes the hypophyseal changes, when present, to be only an accidental finding, without true relationship to the disease. It is apparently accepted by most recent writers on the subject that the disease is invariably characterized by a period of hyperfunction of the pituitary, and that this period is an essential factor in the mechanism of the changes produced, whether it be the primary, or the only, factor, or not. Gigantism is, as its name implies, a symmetrical sort of giant growth, in which both bones and soft tissues attain more than the normal size for the age, though the character of growth remains normal, and without deformity. Like acromegaly, gigantism is caused, or at least partially caused, by hyperfunction of the anterior lobe of the pituitary gland. Unlike acromegaly, gigantism is a disease of adolescence, of the period prior to the union of the epiphyses. Apparently the same process occurring in an adolescent, which causes acromegaly in the adult, produces gigantism. It, then, apparently follows that if the morbid process continues active after epiphyseal ossification occurs, the disease will take on the character of acromegaly, following the gigantism which non-union of the epiphyses permitted to occur first. If the process begins in adult life, the changes will be purely acromegalic; while if the stage of hyperfunction begins and ends prior to epiphyseal union, the condition will be pure gigantism. In any event, the stage of hyperfunction is apparently always followed by a period of hypofunction.

Topic: Pituitary Gland Disorders and Treatments
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
أور في زمـن المـــلك (آبـي _ سيـن 2028 – 2004 ق.م) Or in the time of King (Abe _ Sen 2028 - 2004 BC).

The king Abe Sen is considered (2028 - 2004) the fifth and last king of Third Dynasty of Ur, and sources indicate cuneiform he was crowned king on the throne of the state of Ur III in the tenth month of the ninth year of the rule of his father, King Chusein (2037 - 2029 BC)., And indicate sources also said that he was young when he was crowned on the throne. The sources said that some of the kings belonging to the authority of Ur III has rushed glorifying King Abe O, where raises sources cuneiform to the existence of a number of texts which concluded in the name of King Abe Sen texts still dated for years to rule Chusein, and this was confirmed by one of the texts that go back the Kododo writer son of Uma governor.

Topic: Ancient Egypt and Archaeology
Subfield: Archeology
Field: Arts and Humanities
Domain: Social Sciences
Validation Study of Wave Breaking Influence in a Coupled Wave Model for Hurricane Wind Conditions

As marine winds strengthen, wave breaking becomes increasingly widespread with potentially important consequences for offshore operations. Wave breaking is not included in present marine forecasts. This project addressed the incorporation of wave breaking physics into coupled sea state marine weather forecasting models, with aim of adding accurate wave breaking forecasts to the standard sea state variables. Our approach combined observational and modeling efforts. New results from our field data analyses were synthesized into accurate parameterizations for wave breaking occurrence and strength. The wind input source term was modified for compatibility with the other source terms and physical constraints. These refinements were incorporated in the dissipation and wind input source terms in the spectral wave evolution models used to generate forecasts. The model output results were evaluated critically in systematic tests from moderate to severe wind speeds. After extensive iterations, the model framework is ready for implementation and further testing in operational prototype models.

Topic: Ocean Waves and Remote Sensing
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Action Research of the Multiple Intelligence (MI), Cooperative Learning, and Game-based Teaching into Summer Intensive English Classes for Mixed-level and Mixed-age Students

This study is based on the '2014 the Schweitzer Program' in Taiwan which spanned for four weeks from the 2 nd to 29 th of August.The lessons included four classes of multimedia picture books and eight game-based lessons.The aim of this research is to describe how to integrate the theory of 'Multiple Intelligence (MI)' by Howard Gardner as well as the theories of 'Cooperative Learning', and 'Game-Based Teaching' into summer intensive English classes among mixed-level and mixed-age students.There were 20 participants composed of 13 fifth graders and seven sixth graders with equal members of each gender.The study followed a qualitative action research methodology with the use of interviews, documents and observations.The students had two 60-minute English lessons and one 60-minute multimedia picture book session per week for four weeks with the researcher.This study provided a prototype of lesson plan designs for a group of mixed-level and mixed-age students.Results show that merging games into the teaching content and using 'Game-based Teaching' is significantly suitable for the mixed group.Based on the results, recommendations were provided for both EFL teachers and EFL schools.During lesson plan design, teachers could merge various games into their lessons especially when intended for students of mixed levels.For the schools, it is best to choose teaching materials that combine text with plenty of activities and classroom games.

Topic: EFL/ESL Teaching and Learning
Subfield: Language and Linguistics
Field: Arts and Humanities
Domain: Social Sciences
Prediction of the configuration of a ‘Bardeen–Herring’ dislocation climb source under dynamic conditions

Abstract The sequence of events during the operation of a ‘Bardeen-Herring’ climb source is predicted by using a numerical method in which the dislocation is modelled as a set of finite straight elements. The configuration is determined as a function of the applied stress and an approximate analytical treatment is presented which describes the time dependence of the source operation.

Topic: Metallurgy and Material Forming
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences