jimnoneill/paper-to-field-training huggingface dataset:
Observed Differences in Child Picky Eating Behaviors Between the Child's Home and Center‐ or Home‐based Childcare

Picky eating (PE), which typically defined as having low dietary variety and rejecting new and familiar foods, is a commonly reported problematic eating behavior that emerges during early childhood. PE causes parental concern and has been linked to lack of dietary variety and increased risk of depression, underweight, and developing an eating disorder in the child. Traditionally, parents have been primarily responsible for determining their child's dietary intake. However, the number of children placed in non‐parental, i.e., center‐based childcare (CBC) or home‐based childcare (HBC), has risen substantially, increasing care providers’ influence on the development of children's eating behaviors. Currently little is known about PE behaviors manifested by the child across the home and childcare settings. Furthermore, most research in the area of early childcare focuses on CBC, although 15% of children in non‐parental childcare are cared for in HBC. Therefore, the objective of this research was to investigate observed child PE behaviors across settings, while controlling for the food provided to the child in each setting. Children, ages 3–5 years, were recruited from a CBC (n=26) or HBC (n=24) childcare locations in the Champaign‐Urbana area. Children were videotaped consuming two different lunchtime meals in both their home and childcare for a total of 200 observed mealtimes. Physical and verbal food refusals and avoidances were coded from the videos as PE behaviors. Inter‐rater reliability of Cohen's Kappa &gt;0.90 was achieved for all coders. The McNemar test results revealed that children in CBC expressed all PE behaviors more often at home than at childcare (P&lt;0.0001). Children in HBC expressed more physical refusals and verbal avoidances at home compared to their childcare location (P&lt;0.0001). However, there was no significant difference in the number of verbal refusals between home and HBC and significantly more physical avoidances at HBC than home (P&lt;0.001). Thus, children were observed to respond differently to the same foods based on the mealtime location, and, overall, expressed more PE behaviors at home than in either childcare setting. The findings from this study add to the knowledge base of child eating behaviors and can be used to create specialized, location‐specific intervention and education programs with the goal of raising healthy, independent eaters. Support or Funding Information Christopher Family Foundation Food and Family Program.

Topic: Child Nutrition and Feeding Issues
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Insights into the Design of p97-targeting Small Molecules from Structural Studies on p97 Functional Mechanism

p97, also known as valosin-containing protein or CDC48, is a member of the AAA+ protein family that is highly conserved in eukaryotes. It binds to various cofactors in the body to perform its protein-unfolding function and participates in DNA repair, degradation of subcellular membrane proteins, and protein quality control pathways, among other processes. Its malfunction can lead to many diseases, such as inclusion body myopathy, associated with Paget’s disease of bone and/or frontotemporal dementia, amyotrophic lateral sclerosis disease, and others. In recent years, many small-molecule inhibitors have been deployed against p97, including bis (diethyldithiocarbamate)- copper and CB-5083, which entered the first phase of clinical tests but failed. One bottleneck in the design of p97 drugs is that its molecular mechanism remains unclear. This paper summarizes recent studies on the molecular mechanisms of p97, which may lead to insight into how the next generation of small molecules targeting p97 can be designed.

Topic: Endoplasmic Reticulum Stress and Disease
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Issues Surrounding Post-Adoption Contact in Foster Adoption: The Perspective of Foster-to-Adopt Families and Child Welfare Workers

Current research on open adoption gives less consideration to issues surrounding post-adoption contact with birth parents for children adopted from care. Yet, it is widely recognized that the profile of the children and their birth parents, as well as the quality of post-adoption contacts, vary considerably depending on the context in which the adoption takes place. This article is based on interviews with 32 child welfare workers and 16 foster-to-adopt families. It focuses specifically on aspects and conditions that should be taken into consideration when determining whether or how contact between the adopted child and the birth family should be maintained. Our results show that there are distinctive challenges and dilemmas for open adoption in situations where the adopted child comes from a maltreating family, under the responsibility of child welfare services.

Topic: Child Welfare and Adoption
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
Chemical constituents in root bark of Changium smyrnioides

Objective To study the chemical constituents from the root bark of Changium smyrnioides. Methods Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, and recycling preparative HPLC from the ethanol extract in the root bark of C. smyrnioides, and their structures were elucidated by the physicochemical characteristics and spectral analyses. Results Fifteen chemical constituents were obtained and identified as imperatorin(1), phellopterin(2), xanthotoxol(3), 5-hydroxy-8-methoxy-psoralen(4), vanillic acid(5), alloimperatorin(6), psoralen(7), bergapten(8), 8-O-β-D-glucopyranosyl-5-methoxylpsoralen(9), isopimpinellin(10), caffeic acid(11), aurantiamide acetate(12), vaginatin(13), β-sitosterol(14), and succinic acid(15). Conclusion Compounds 6—13 are isolated from the plants in Changium Wolff for the first time.

Topic: Traditional Chinese Medicine Analysis
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors\nof HIV-1 Integrase

Human immunodeficiency virus type-1 integrase is an essential enzyme for effective viral\nreplication and hence a valid target for the design of inhibitors. We report here on the design\nand synthesis of a novel series of phthalimide analogues as integrase inhibitors. The short\nsynthetic pathway enabled us to synthesize a series of analogues with a defined structure\ndiversity. The presence of a single carbonyl−hydroxy−aromatic nitrogen motif was shown to\nbe essential for the enzymatic activity and this was confirmed by molecular docking studies.\nThe enzymatically most active compound from this series is 7-(3,4-dichlorobenzyl)-5,9-dihydroxypyrrolo[3,4-&lt;i&gt;g&lt;/i&gt;]quinoxaline-6,8-dione (&lt;b&gt;15l&lt;/b&gt;) with an IC&lt;sub&gt;50&lt;/sub&gt; value of 112 nM on the HIV-1\nintegrase enzyme, while ((7-(4-chlorobenzyl)-5,9-dihydroxy-pyrrolo[3,4-&lt;i&gt;g&lt;/i&gt;]quinoxaline-6,8-dione\n(&lt;b&gt;15k&lt;/b&gt;)) showed an EC&lt;sub&gt;50&lt;/sub&gt; of 270 nM against HIV-1 in a cell-based assay.

Topic: HIV/AIDS drug development and treatment
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Halogenodisilanes

The syntheses of bromo-, chloro-, and fluoro-disilanes are reported, and the preliminary identification of 1-bromo-1-chlorodisilane and 1-bromo-1,1-dichlorodisilane. The 1H and 19F n.m.r. parameters of these and related compounds are reported and discussed.

Topic: Silicone and Siloxane Chemistry
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
University Counseling Center Off-Campus Referrals

Abstract University counseling centers (UCC) must rely on referrals to off-campus providers, due to limited staffing, severity of clients' issues, and ethical treatment considerations. In a mixed method design, this study found that 42% of clients were unsuccessful in connecting with an off-campus provider when referred by a university counseling center therapist. Clients of color were more unsuccessful in connecting with an off-campus provider than Caucasian clients. Regardless of ethnicity, clients reported that therapist follow up, accessible referral sources, and high personal motivation assisted in a successful referral process. Financial issues were the primary inhibitory factor for the referral process. Suggestions for clinical practice and university counseling center policies are provided.

Topic: Counseling Practices and Supervision
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
EFEKTIVITAS TAMAN BERMAIN/PLAYGROUND INDOOR PADA APARTEMEN HEGARMANAH BANDUNG

Abstract: The apartment as a residential facility that is built vertically, has complete facilities including a children's playground, most of which are indoors, due to limited land. The effectiveness of the indoor playroom becomes an interesting issue to study, considering that most children like challenges in open spaces. The purpose of the study was to gain knowledge about the effectiveness of indoor playgrounds in apartment buildings. The research was explored through distributing questionnaires to a number of room users, also accompanied by observations. The results of the study indicate that the users of the indoor playroom are regular users who routinely use the existing facilities.Abstrak: Apartemen sebagai sebuah fasilitas hunian yang dibangun secara vertikal, memiliki kelengkapan fasilitas termasuk taman bermain anak yang hampir sebagian besar berada di dalam ruangan, karena keterbatasan lahan. Efektifitas ruang bermain indoor, menjadi sebuah permasalahan yang menarik utuk dikaji, mengingat kebanyakan anak, menyukai tantangan di ruang terbuka. Tujuan penelitian adalah untuk mendapatkan pengetahuan mengenai efektifitas taman bermain indoorpada bangunan apartemen. Penelitian digali melalui penyebaran kuesioner kepada sejumlah pengguna ruang, juga disertai dengan pengamatan. Hasil penelitian menunjukkan indikasi bahwa pengguna ruang bermain indoor adalah merupakan pengguna tetap yang secara rutin memakai fasilitas yang ada.

Topic: Architectural and Urban Studies
Subfield: Conservation
Field: Arts and Humanities
Domain: Social Sciences
Seismic Sequence Stratigraphy and Structural Trends of Late Cretaceous Carbonate Tidal Channel Fairways from Onshore Giant Oil Field in Middle East

Preview this conference paper: Seismic Sequence Stratigraphy and Structural Trends of Late Cretaceous Carbonate Tidal Channel Fairways from Onshore Giant Oil Field in Middle East, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/2214-4609/2019/GCA15-1.gif

Topic: Geological and Geophysical Studies
Subfield: Geology
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

HD (Huntington's disease) is a late onset heritable neurodegenerative disorder that is characterized by neuronal dysfunction and death, particularly in the cerebral cortex and medium spiny neurons of the striatum. This is followed by progressive chorea, dementia and emotional dysfunction, eventually resulting in death. HD is caused by an expanded CAG repeat in the first exon of the HD gene that results in an abnormally elongated polyQ (polyglutamine) tract in its protein product, Htt (Huntingtin). Wild-type Htt is largely cytoplasmic; however, in HD, proteolytic N-terminal fragments of Htt form insoluble deposits in both the cytoplasm and nucleus, provoking the idea that mutHtt (mutant Htt) causes transcriptional dysfunction. While a number of specific transcription factors and co-factors have been proposed as mediators of mutHtt toxicity, the causal relationship between these Htt/transcription factor interactions and HD pathology remains unknown. Previous work has highlighted REST [RE1 (repressor element 1)-silencing transcription factor] as one such transcription factor. REST is a master regulator of neuronal genes, repressing their expression. Many of its direct target genes are known or suspected to have a role in HD pathogenesis, including BDNF (brain-derived neurotrophic factor). Recent evidence has also shown that REST regulates transcription of regulatory miRNAs (microRNAs), many of which are known to regulate neuronal gene expression and are dysregulated in HD. Thus repression of miRNAs constitutes a second, indirect mechanism by which REST can alter the neuronal transcriptome in HD. We will describe the evidence that disruption to the REST regulon brought about by a loss of interaction between REST and mutHtt may be a key contributory factor in the widespread dysregulation of gene expression in HD.

Topic: Genetic Neurodegenerative Diseases
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Overall station balance and decomposability for non-Markovian queueing networks

Introducing the concept of overall station balance which extends the notion of station balance to non-Markovian queueing networks, several necessary and sufficient conditions are given for overall station balance to hold. Next the concept of decomposability is introduced and it is related to overall station balance. A particular case corresponding to a Jackson-type queueing network is considered in some more detail.

Topic: Advanced Queuing Theory Analysis
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
You Found It Where?!?

Anesthesia and Operative Service, Department of Surgery, Brooke Army Medical Center, San Antonio, Texas 78234-6200.In Reply:--Noel points out that the catheters used in our study [1]retrieved less than half of the venous air embolus and that a continuous column of frothy blood extending from the superior vena cava into the pulmonary vasculature was noted on necropsy. He indicates that, if the catheters were positioned in the pulmonary artery, a larger portion of the air embolus may have been extracted, and more animals would have survived. The rationale for positioning multiorifice catheters at the superior vena cava-right atrial (SVC-RA) junction was based on previous in vitro studies that concluded that an air lock occurs in the right atrium. Those evaluations documented that more than 80% of an air embolus can be removed by a multiorifice catheter located at the SVC-RA junction. [2,3]The in vivo animal studies have confirmed that the majority of the air can be removed by a catheter located at the SVC-RA junction. [4-7]However, the design of those studies may have contributed to those findings. Those studies injected air into the internal jugular or other large central vein. This may cause streaming of the air and a right heart air lock. Our study design attempted to mimic a venous air embolism occurring from a dural sinus during a seated procedure.Because of the results of our investigation, we postulate that there may be a fundamental difference in the blood fluid interface presented to the catheters when air is injected into a major vessel as opposed to a dural sinus. The air injected into the dural sinus may undergo considerable fractionation, as opposed to air injected into the central circulation. Is the frothy mixture less capable of creating a right heart air lock and thus less capable of aspiration? If so, it would explain the relatively low percentage of air aspirated compared to the other animal study designs. Based on the low volume of aspiration and the necropsy findings, should we reevaluate the location of the catheter for air aspiration? Would a high-volume aspiration catheter in the pulmonary vasculature be more effective than one at the SVC-RA border? Questions remain to be answered in future investigations.Regarding the design of the catheter, Noel is correct that the electrocardiogram electrode design of the JX-318 catheter (Arrow International, Reading, PA) is probably better. The design of the JX-318 catheter for aspiration of air, however, appears to be inferior and has never been evaluated in any study of air aspiration.Paul D. Mongan, M.D., Jon A. Hinman, D.V.M., M.D., Anesthesia and Operative Service, Department of Surgery, Brooke Army Medical Center, San Antonio, Texas 78234-6200.

Topic: Cardiovascular and Diving-Related Complications
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
A geometric construction of representations of the Berezin-Toeplitz quantization

For a Kähler manifold $X$ equipped with a prequantum line bundle $L$, we give a geometric construction of a family of representations of the Berezin-Toeplitz deformation quantization algebra $(C^\infty(X)[[\hbar]],\star_{BT})$ parametrized by points $z_0 \in X$. The key idea is to use peak sections to suitably localize the Hilbert spaces $H^{0}\left(X,L^{\otimes m}\right)$ around $z_{0}$ in the large volume limit.

Topic: Geometry and complex manifolds
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Remarkable impact of low BiYbO<sub>3</sub> doping levels on the local structure and phase transitions of BaTiO<sub>3</sub>

Bi<sup>3+</sup> with a stereochemically active lone-pair of electrons induces severe lattice strain in BaTiO<sub>3</sub> as revealed by a significant Raman shift of the mode associated with the O–Ti–O bonds.

Topic: Ferroelectric and Piezoelectric Materials
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Expanding Frameworks

Research Article| June 01 2000 Expanding Frameworks Zeynep Çelik Zeynep Çelik Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (2000) 59 (2): 152–153. https://doi.org/10.2307/991587 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Zeynep Çelik; Expanding Frameworks. Journal of the Society of Architectural Historians 1 June 2000; 59 (2): 152–153. doi: https://doi.org/10.2307/991587 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Copyright 2000 The Society of Architectural Historians Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Cultural Heritage Management and Preservation
Subfield: Archeology
Field: Arts and Humanities
Domain: Social Sciences
Macromolecular MRI Contrast Agents with Small Dendrimers:  Pharmacokinetic Differences between Sizes and Cores

Large macromolecular MRI contrast agents with albumin or dendrimer cores are useful for imaging blood vessels. However, their prolonged retention is a major limitation for clinical use. Although smaller dendrimer-based MRI contrast agents are more quickly excreted by the kidneys, they are also able to visualize vascular structures better than Gd-DTPA due to less extravasation. Additionally, unlike Gd-DTPA, they transiently accumulate in renal tubules and thus also can be used to visualize renal structural and functional damage. However, these dendrimer agents are retained in the body for a prolonged time. The purpose of this study was to obtain information from which a macromolecular dendrimer-based MRI contrast agents feasible for use in further clinical studies could be chosen. Six small dendrimer-based MRI contrast agents were synthesized, and their pharmacokinetics, whole-body retention, and dynamic MRI were evaluated in mice to determine an optimal agent in comparison to Gd-[DTPA]-dimeglumine. Diaminobutane (DAB) dendrimer-based agents cleared more rapidly from the body than polyamidoamine (PAMAM) dendrimer-based agents with the same numbers of branches. Smaller dendrimer conjugates were more rapidly excreted from the body than the larger dendrimer conjugates. Since PAMAM-G2, DAB-G3, and DAB-G2 dendrimer-based contrast agents showed relatively rapid excretion, these three conjugates might be acceptable for use in further clinical applications.

Topic: Dendrimers and Hyperbranched Polymers
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Scientific Opinion on the pest categorisation of<i>Aculops fuchsiae</i>

The Panel on Plant Health of the European Food Safety Authority performed a pest categorisation of Aculops fuchsiae, a mite listed in Annex II, Part A, Section I of Council Directive 2000/29/EC as a harmful organism not known to occur in the community. A. fuchsiae is, however, established in France and the UK and it was also reported as transient in Belgium and Germany (but systematic surveys are lacking). A. fuchsiae is a distinct taxonomic entity. The known hosts of A. fuchsiae are Fuchsia spp. This exotic plant genus is naturalised in several areas of Europe and is widely present in the risk assessment area, both in the open field and under protected cultivations, as well as in gardens. The impact in terms of quality loss on fuchsia plants caused by the pest has been described in the European Union. However, no quantitative data on these losses have been reported yet. Plants for planting are the main pathway for introduction and spread of A. fuchsiae, which may cause severe impacts on the intended use of the plants for planting. In Europe, the climatic conditions do not seem to be the key limiting factor for establishment and spread in the open field and under protected conditions. Establishment and spread could occur provided that suitable hosts (Fuchsia spp.) are present. Further spread is anticipated from the areas where the pest is currently present, mainly by movement of plant material through trade and exchange.

Topic: Insect-Plant Interactions and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences