MP69-17 THE EXPRESSION OF EMERGING IMMUNE CHECKPOINT GENE B7-H3 IS ASSOCIATED WITH THE PROGNOSIS OF ADRENOCORTICAL CANCER PATIENTS

You have accessJournal of UrologyAdrenal (MP69)1 Apr 2019MP69-17 THE EXPRESSION OF EMERGING IMMUNE CHECKPOINT GENE B7-H3 IS ASSOCIATED WITH THE PROGNOSIS OF ADRENOCORTICAL CANCER PATIENTS Jiayu Liang*, Zhihong Liu, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu, Yuchun Zhu, Jiayu Liang, Zhihong Liu, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, and Yiping Lu Jiayu Liang*Jiayu Liang* More articles by this author , Zhihong LiuZhihong Liu More articles by this author , Chuan ZhouChuan Zhou More articles by this author , Kan WuKan Wu More articles by this author , Fuxun ZhangFuxun Zhang More articles by this author , Fan ZhangFan Zhang More articles by this author , Yiping LuYiping Lu More articles by this author , Yuchun ZhuYuchun Zhu More articles by this author , Jiayu LiangJiayu Liang More articles by this author , Zhihong LiuZhihong Liu More articles by this author , Chuan ZhouChuan Zhou More articles by this author , Kan WuKan Wu More articles by this author , Fuxun ZhangFuxun Zhang More articles by this author , Fan ZhangFan Zhang More articles by this author , and Yiping LuYiping Lu More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557050.01369.92AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Adrenocortical carcinoma (ACC) is a malignant endocrine tumor. Due to high tumor recurrence rate, the post-operative disease-free survival of ACC is low. Our research aims to explore the role of Emerging immune checkpoint gene, B7-H3, in the prognosis prediction of ACC. METHODS: Clinical and genetic data of ACC were retrieved from the ACC dataset of The Cancer Genome Atlas (TCGA) database (n=75). The retrospective analysis of 65 patients diagnosed with adrenocortical carcinoma between 2009 and 2017 in our hospital was performed. The archived, formalin-fixed, paraffin-embedded (FFPE) samples were collected for Immunohistochemical(IHC) analysis of B7-H3. Kaplan-Meier curve method and log-rank test were used in survival analyses. RESULTS: The expression level of B7-H3 was significantly correlated with overall survival (HR=2.4, P = 0.033) and disease-free survival (HR=3.7, P=0.00049) of ACC patients. Also, the higher expression of B7-H3 was associated with advanced pathological stage of ACC (P = 0.0276). Furthermore, the analyses of B7-H3-related IHC score validated the positive correlation between B7-H3 and multiple clinical features, such as OS, tumor stage, local recurrence and distant metastases of ACC (P < 0.05). CONCLUSIONS: B7-H3 plays a crucial role in ACC. The high expression of B7-H3 suggests poor prognosis of ACC patients. Its potential molecular mechanisms warrant further investigation. Source of Funding: none Chengdu, China, People’s Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e990-e990 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jiayu Liang* More articles by this author Zhihong Liu More articles by this author Chuan Zhou More articles by this author Kan Wu More articles by this author Fuxun Zhang More articles by this author Fan Zhang More articles by this author Yiping Lu More articles by this author Yuchun Zhu More articles by this author Jiayu Liang More articles by this author Zhihong Liu More articles by this author Chuan Zhou More articles by this author Kan Wu More articles by this author Fuxun Zhang More articles by this author Fan Zhang More articles by this author Yiping Lu More articles by this author Expand All Advertisement PDF downloadLoading ...

Topic: Cancer, Hypoxia, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences