jimnoneill/paper-to-field-training huggingface dataset:
International Development Partnerships and Diffusion of Renewable Energy Technologies in Developing Countries: Exploratory Study in Costa Rica

Worldwide, 1.4 billion people virtually live in darkness after sunset. New lighting technologies, such as light emitting diodes, powered by renewable energy allow non-electrified communities to access for the first time in their lives clean, durable, affordable and higher quality lighting service. The international NGOs play an important intermediary role in diffusion of these technologies to off-grid subsistence marketplaces and operate via development partnerships. My PhD research explores the nature of these partnerships and their effectiveness in achieving the development outcomes. This paper presents the exploratory case study in Talamanca, Costa Rica completed as part of the PhD research. The paper presents the background, conceptual framework and methodology for my PhD and then focuses on the case study which contrasted and examined two development partnerships driven by international NGOs. The study acknowledged the catalytic role of the international NGOs and emphasized the centrality of local organizations and their capacities in successful implementation of development interventions. It indicated the criteria for effective partnership in this area and proposed elements of a conceptual framework for the analysis of the development partnership in renewable energy lighting in subsistence marketplaces.

Topic: Innovation and Socioeconomic Development
Subfield: Business and International Management
Field: Business, Management and Accounting
Domain: Social Sciences
Design improvement to reduce noise effect in CDMA multiple access optical systems based on new (2-D) code using spectral/spatial half-matrix technique

Abstract This paper presents for non-coherent Optical Code Division Multiple Access (OCDMA) systems a new optical code namely Two-Dimensional Half Spectral/Spatial Zero Cross Correlation (2D-HSSZCC) code based on a One-Dimensional Zero Cross Correlation (1D-ZCC) code already developed using block matrices characterized by a high capacity. The results of simulation show that the use of the new (2D-HSSZCC) code eliminates totally the Multiple Access Interferences (MAI) due to the zero cross correlation flexibility, and less complexity of the code construction which produces a very low bit error rate of closely (4×10 −18 ) at 1 Gbps for four users with a low power source of −12.60 dBm to reach a high data rate and high number of simultaneous users upper to closely 149, save an effective power around −1.35 dBm, −3.3d Bm compared between those provides by (Two-Dimensional dynamic cyclic shift (2D-DCS) code and Two-Dimensional Dimensional Diluted Perfect Difference (2D-DPD) and (1D-ZCC) code, and increase the cardinality percentage upper to 1.58, 2.19, 2.33 and 3.9 times comparing to (2D-DCS) code, 2D-DPD code, 1D-ZCC code and Two-Dimensional Flexible Cross Corelation/Modified Double Weight (2D-FCC/MDW) code. On the other hand, 2D-HSSZCC code is comparied with other codes which has it same property namely Two-Dimensional zero cross correlation/multi diagonal (2D-ZCC/MD) and (2D-MD) codes where the increased percentage in system capacity was 1.38 and 1.05 times, respectively. Finally, the results obtained in part 1 (with Matlab software) were confirmed and validated with the Optisystem software, the proposed system gave a better BER minimum value around 10 −21 and a maximum value of the Q factor of around 9.4 at 622 Mbps of data rate when the number of simultaneous users increases.

Topic: graph theory and CDMA systems
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Protective Effects of Ethanolic Extract of Nigella sativa Seed in Paracetamol Induced Acute Hepatotoxicity In vivo

Paracetamol overdose causes serious liver necrosis. Hepatoprotective activity of ethanolic extract of Nigella sativa in Paracetamol induced acute hepatotoxicity was investigated in rats. Fasted male Wistar rats were orally treated with Nigella sativa extract in graded doses for 5 days followed by Nigella sativa extract and paracetamol 3 g kg(-1) on 6 and 7th day. Circulatory liver markers and reduced glutathione (GSH) levels were estimated and histopathological study of liver performed. Paracetamol caused a significant increase in serum alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and total Bilirubin and a significant decrease in GSH compared to control. Nigella sativa pretreatment significantly prevented the increase in liver enzymes and total bilirubin and decrease in GSH level as compared to paracetamol group. Liver histopathology showed marked reduction in sinusoidal dilatation, midzonal necrosis, portal triaditis and occasional apoptosis in Nigella sativa extract treated groups as compared to group receiving only paracetamol. Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Further research is needed to advocate its prophylactic use for drug induced hepatotoxicity.

Topic: Nigella sativa pharmacological applications
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Figure S6 from FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

&lt;p&gt;Figure S6. Correlation of HPV-expression and FGFR1 mRNA expression.&lt;/p&gt;

Topic: Fibroblast Growth Factor Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Advancing Nonmarket Strategy Research: Institutional Perspectives in a Changing World

Executive Overview Nonmarket strategy is now well established as a legitimate field of research. In this paper, we review the dominant paradigms in contemporary nonmarket research and report on the key insights and findings from those perspectives. We use this review to suggest that the integration of institutional and strategic perspectives provides a logical path for the continued development of nonmarket strategy research going forward. Looking ahead, our premise is that institutional perspectives will have an increased relevance to nonmarket scholarship, particularly with the increasing importance of emergent economies to international business. As companies are required to invest more in nonmarket practices, and adapt those practices to unique country contexts, we anticipate that research will increasingly draw from multiple conceptual paradigms and perspectives.

Topic: Corporate Finance and Governance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
The Association of Kindergarten Entry Age with Early Literacy Outcomes

The authors investigated whether age at kindergarten entry was associated with early literacy achievement gaps and if these gaps persisted over time. Using the kindergarten age eligibility cutoff date, they created 2 groups of students who represented the oldest and youngest children in a cohort of students in high-poverty, low-performing schools. The authors followed 405 students from the beginning of kindergarten until the end of Grade 2. Results indicated that the youngest students scored lower than their oldest peers at the beginning of kindergarten on various early literacy measures. The early-age achievement gap, however, narrowed over time but did not close completely by the end of Grade 2. Implications for parents and educators are discussed.

Topic: Early Childhood Education and Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney.

BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and α-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

Topic: Connective Tissue Growth Factor Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Sex Education Policy In Florida: Strategies For Change

Sex education policies and programs in Florida are largely dominated by the abstinence-only approach. This paper makes the case that abstinence-only education is a failing policy in Florida, and evaluates strategies advocates may use in order to accomplish reform. Three different strategies are evaluated: countywide school district reform, statewide rejection of federal abstinence-only funding, and statewide standardization of sex education via legislation. Contrasts are drawn between all three strategies with regard to their potential impact on sex education policy in Florida, viability, and the challenges they present to advocates. This paper concludes that statewide standardization of sex education in Florida represents the best way to remedy the problem of insufficient sex education, but is unlikely to occur without increased bipartisan support in the Florida legislature. Statewide rejection of Title V federal abstinence-only funds remains an important policy goal for the purpose of accomplishing an end to federal abstinence grants but would likely achieve very little for Florida's students. Countywide sex education changes are thus far the only substantive victory for sex education advocates in Florida and should be instituted across the state with advocates taking special care to engage teachers, medical professionals, parents and local community leaders.

Topic: Adolescent Sexual and Reproductive Health
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Dietary Fibre in the Diabetic Diet

ABSTRACT. The diabetic diet is still in its developing stage. The functions of the different fiber fractions is inadequately known. Today, we recommend the diabetic patient to have a high carbohydrate intake such as increasing the intake of starchy foods with higher fiber context. For example eating whole meal bread instead of white bread, eating fruits instead of drinking juice etc. It is also wise to increase fiber content in the diet by choosing high fiber content foods than to use supplements or fiber medications. With a high fiber diet, the diabetic patients can eventually decrease their insulin or tablet medication.

Topic: Diet and metabolism studies
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Mechanisms of long-term potentiation: EPSP/spike dissociation, intradendritic recordings, and glutamate sensitivity

Synaptic efficacy is modified following a brief train of high-frequency stimulation (HFS) to a cell's afferent fibers (long-term potentiation; LTP). An alteration in the postsynaptic response to endogenous neurotransmitter, as a result of an increase in the number of postsynaptic receptors, has been proposed (Baudry and Lynch, 1980). We tested this hypothesis in the CA1 hippocampus by intracellularly recording the postsynaptic response to localized application of glutamate before and after induction of LTP. When LTP was produced, there was no corresponding change in neuronal sensitivity to glutamate application. These findings are not consistent with the hypothesis that HFS of fibers in CA1 stratum radiatum induces an increase in the number of postsynaptic glutamate receptors in CA1 pyramidal cells. Previous reports concerning LTP have indicated a dissociation between the degree of potentiation in the population EPSP and population spike. Simultaneous recordings of the CA 1 population EPSP and population spike in hippocampal slices confirmed that the degree of potentiation of the population spike was not predicted by the degree of potentiation in the population EPSP. Intradendritic impalements were obtained to more accurately assess changes in the intracellular EPSP following HFS. When the population EPSP was potentiated, there was also a potentiated intradendritic EPSP. When the population spike was potentiated following HFS, however, the intradendritic EPSP was often unchanged; in the same cell, there was an increased probability of action potential discharge to stimulation which was originally (i.e., pre-HFS) subthreshold for spike initiation. These results indicate that the EPSP (intracellular or extracellular) may be potentiated following HFS, but this potentiation is not a prerequisite for, or a correlation of, potentiation in the population spike. Furthermore, these findings suggest that LTP is composed of 2 independent components--a synaptic component and an EPSP-to-spike coupling component.

Topic: Neuroscience and Neuropharmacology Research
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
246. A synthesis of 5 : 6 : 7 : 8-tetrahydrophenanthridine and its derivatives

J. Kenner, W. H. Ritchie and F. S. Statham, J. Chem. Soc., 1937, 1169 DOI: 10.1039/JR9370001169

Topic: Synthesis and Reactions of Organic Compounds
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
A general kinetic approach to investigation of active-site availability in macromolecular catalysts

A potentially general kinetic method for the investigation of active-site availability in preparations of macromolecular catalysts was developed. Three kinetic models were considered: (a) the conventional two-step model of enzyme catalysis, where the preparation contains only active catalyst (Ea) and inert (i.e. non-binding, non-catalytic) material (Ei); (b) an extension of the conventional model (a) involving only Ea and Ei, but with non-productive binding to Ea (in addition to productive binding); (c) a model in which the preparation contains also binding but non-catalytic material (Eb), predicted to be present in polyclonal catalytic antibody preparations. The method involves comparing the parameters Vmax and Km obtained under catalytic conditions where substrate concentrations greatly exceed catalyst concentration with those (k, the limiting value of the first-order rate constant, kobs, at saturating concentrations of catalyst; and K) for single-turnover kinetics, in which the reverse situation obtains. The active-site contents of systems that adhere to model (a) or extensions that also lack Eb, such as the non-productive binding model (b), may be calculated using [Ea]T = Vmax/k. This was validated by showing that, for α-chymotrypsin, identical values of [Ea]T were obtained by the kinetic method using Suc-Ala-Ala-Pro-Phe-4-nitroanilide as substrate and the well-known ‘all-or-none’ spectroscopic assay using N-trans-cinnamoylimidazole as titrant. For systems that contain Eb, such as polyclonal catalytic antibody preparations, Vmax/k is more complex, but provides an upper limit to [Ea]T. Use of the kinetic method to investigate PCA 271-22, a polyclonal catalytic antibody preparation obtained from the antiserum of sheep 271 in week 22 of the immunization protocol, established that [Ea]T is less than approx. 8% of [IgG], and probably less than approx. 1% of [IgG].

Topic: Advanced biosensing and bioanalysis techniques
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Hydrothermal Synthesis of V<sub>0.13</sub>Mo<sub>0.87</sub>O<sub>2.935</sub> Nanowires with Strong Blue Photoluminescence

Hexagonal V0.13Mo0.87O2.935 nanowires were hydrothermally synthesized at 220 °C for the first time. X-ray diffraction and field-emission scanning electron microscopy were utilized to characterize the phase and morphology of the nanowires, respectively. Transmission electron microscopy and selected area electron diffraction indicate that the nanowires are single crystalline, growing along the [001] direction. Interestingly, the nanowires easily become amorphous under the electron irradiation. The comparative hydrothermal experiments show that the molar ratio between the starting reagents of Mo and NH4VO3 plays a vital role in the anisotropic growth of nanowires. The photoluminescence measurement demonstrates that these nanowires exhibit two strong emission peaks at 420 and 438 nm, which are probably related to the intrinsic oxygen vacancies.

Topic: Transition Metal Oxide Nanomaterials
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
New distribution records for 48 species of Polyporaceae in western Canada

Forty-eight species of Polyporaceae are reported for the first time from the four western Provinces and Yukon and District of Mackenzie of the Northwest Territories. The number of species reported are from Manitoba 11, Saskatchewan 8, Alberta 20, British Columbia 10, Yukon Territory 4, and Northwest Territories (Mackenzie Dist.) 13.

Topic: Lichen and fungal ecology
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Physical limits on kinesin-5–mediated chromosome congression in the smallest mitotic spindles

A characteristic feature of mitotic spindles is the congression of chromosomes near the spindle equator, a process mediated by dynamic kinetochore microtubules. A major challenge is to understand how precise, submicrometer-scale control of kinetochore micro­tubule dynamics is achieved in the smallest mitotic spindles, where the noisiness of microtubule assembly/disassembly will potentially act to overwhelm the spatial information that controls microtubule plus end–tip positioning to mediate congression. To better understand this fundamental limit, we conducted an integrated live fluorescence, electron microscopy, and modeling analysis of the polymorphic fungal pathogen Candida albicans, which contains one of the smallest known mitotic spindles (&lt;1 μm). Previously, ScCin8p (kinesin-5 in Saccharomyces cerevisiae) was shown to mediate chromosome congression by promoting catastrophe of long kinetochore microtubules (kMTs). Using C. albicans yeast and hyphal kinesin-5 (Kip1p) heterozygotes ( KIP1/kip1∆), we found that mutant spindles have longer kMTs than wild-type spindles, consistent with a less-organized spindle. By contrast, kinesin-8 heterozygous mutant ( KIP3/kip3∆) spindles exhibited the same spindle organization as wild type. Of interest, spindle organization in the yeast and hyphal states was indistinguishable, even though yeast and hyphal cell lengths differ by two- to fivefold, demonstrating that spindle length regulation and chromosome congression are intrinsic to the spindle and largely independent of cell size. Together these results are consistent with a kinesin-5–mediated, length-dependent depolymerase activity that organizes chromosomes at the spindle equator in C. albicans to overcome fundamental noisiness in microtubule self-assembly. More generally, we define a dimensionless number that sets a fundamental physical limit for maintaining congression in small spindles in the face of assembly noise and find that C. albicans operates very close to this limit, which may explain why it has the smallest known mitotic spindle that still manifests the classic congression architecture.

Topic: Microtubule and mitosis dynamics
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
262 Effects of phase-feeding programs on growth performance of nursery pigs

Abstract Production systems commonly have multiple fill events in the nursery, which can lead to inaccurate feeding of dietary budgets. A simpler feeding program may provide practical benefits to producers. Five trials were conducted to compare nursery phase-feeding programs. Two treatments consisting of a 2-phase or a single-phase program were applied for 22 d postweaning. The 2-phase program consisted of a feed budget of 1.4 kg of a phase 1 diet formulated with 1.45% SID Lys and 5.4 kg of a phase 2 diet with 1.36% SID Lys. The single-phase program provided 6.8 kg of a unique diet with 1.38% SID Lys. Diets were corn, soybean meal, and whey permeate-based and contained 3,000 mg/kg Zn. All other nutrients met or exceeded the NRC (2012) recommendations. After the experimental period, pigs were fed a common diet for 23 d. In the five trials, 5,090 pigs were used with a total of 63 and 69 replicates per treatment for 2-phase and single-phase programs, respectively. There was no treatment × trial interactions (P &amp;gt; 0.10), thus data was combined for statistical analysis using SAS PROC MIXED. From d 0 to 22, pigs fed the single-phase program had higher (P = 0.041) ADFI and a tendency (P = 0.075) for higher BW. From d 22 to 45, pigs previously fed the single-phase program had a tendency (P = 0.057) for higher ADG. Overall (d 0 to 45), pigs fed the single-phase program had higher (P = 0.037) ADG and a tendency (P = 0.077) for higher final BW, with comparable (P &amp;gt; 0.10) ADFI and G:F to the 2-phase program. In conclusion, feeding a single-phase nursery program in the first 22 d postweaning resulted in higher overall ADG and similar ADFI and G:F compared to a 2-phase nursery program.

Topic: Animal Nutrition and Physiology
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Quantum Field Theory of Black Hole Perturbations with Backreaction IV. Spherically symmetric 2nd order Einstein-Maxwell sector in generalised gauges

In previous papers of this series we analysed the reduced phase space approach to perturbations of Einstein-Maxwell theory to second order around spherically symmetric backgrounds in the Gullstrand Painlevé Gauge and confirmed consistency with previous approaches. In this paper we generalize this result and show that the analysis can be performed in gauges for the background variables compatible with the Gullstrand Painlevé gauge. We obtain the same structure for the reduced Hamiltonian that contains the well known Regge-Wheeler and Zerilli potentials. Possible applications of this generalization are discussed.

Topic: Cosmology and Gravitation Theories
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences