jimnoneill/paper-to-field-training huggingface dataset:
[Neoadjuvant systemic chemotherapy with VMC (vinblastine, methotrexate and cisplatin) in locally advanced carcinoma of the bladder].

A total of 25 patients with locally advanced bladder cancer, staged T3 and T4, have received neo-adjuvant VMC chemotherapy with Vinblastine, Methotrexate and Cisplatinum. The evaluable patients were 21 and after cystectomy demonstrated the following responses: pCR in one case (4%), pRP in ten cases (48%), pNC in 10 patients (48%). Toxicity was mainly represented by leukopenia in 18 patients (82%), one of them died from neutropenic sepsis. After a median follow-up time of 12 months (range 6-39) 5 patients already experienced relapse of the disease.

Topic: Bladder and Urothelial Cancer Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
[Effect of a derivative of GABA, phenibut, on behavior and the activity of visual cortex neurons of the rabbit during elaboration of a defensive reflex and internal inhibition].

In experiments on alert non-immobilized rabbits the effect of subcutaneous administration of the GABA-derivate--phenibut on behaviour, slow potentials and impulse activity of neurones of the visual cortex was studied during elaboration of a defensive reflex to light flashes and of conditioned inhibition. During the action of phenibut late negative-positive components of the evoked potentials to flashes, corresponding inhibitory pauses and postinhibitory activation gradually increased; then stable predominance of slow high-amplitude potential oscillations and corresponding neuronal group bursts appeared, separated by inhibitory pauses and in intersignal periods. Reinforcing stimulus, as before phenibut administration, lowered the amplitudes of slow potential oscillations and weakened inhibitory pauses in neuronal impulse activity. Dynamics of movements in response to the stimuli was of a phasic character. 3 hours after phenibut administration the discrimination of reinforced and inhibitory light flashes has distinctly improved. The obtained results confirm the initial concept of the significant role of the GABA-ergic inhibitory system in the process of elaboration of internal inhibition.

Topic: Neurological Disorders and Treatments
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
736. Delays in Malaria Recognition and Door to Anti-malarial Time in a South London Hospital

Abstract Background The prompt recognition and treatment of Plasmodium falciparum is necessary to prevent death. We reviewed data from a cohort of patients presenting with malaria to Kings College Hospital NHS Trust, London. Methods Retrospective review of electronic records and drug charts of patients diagnosed with malaria from Jan 2019- March 2021. Results 109 cases of malaria were identified representing travellers from 11 Sub-Saharan African countries: Nigeria(38%), Sierra Leone(33%), Ivory Coast(10%). The age range varied from 4 to 76 years with a mean of 44, 66% of the cohort was male. 22 cases occurred during the COVID-19 Pandemic. The commonest symptoms were Fever (97%), Headache (92%) and malaise (72%). P. falciparum was present in 99% cases. A travel history was taken in 94% of cases. Malaria was considered by the first clinician in 82% of cases with the second highest differential being a viral illness. In 6 cases, it took 4 to 11 medical reviews before malaria was considered. 29 patients met the UK criteria for severe malaria. Door to antimalarial time varied from 1 to 128 hours, with a median of 7.4 hours. 46% of the cohort received intravenous Artesunate as their first antimalarial. Extreme delays occurred were clinicians did not consider malaria, patients had negative films or a patient did not declare a travel history when asked. 1 patient died of cerebral malaria with a door to needle time of 2hr 3min. Where a reason for delay is documented, drug availability represented the highest cause with mean delay from prescribing antimalarial to giving antimalarial of 2.7 hours. There was no difference in door to antimalarial administration during the COVID-19 Pandemic, but patients did have a delay in presentation to hospital from onset of symptoms, mean 6.2 days pre-pandemic, 10.5 days during pandemic, this was not statistically significant (P= 0.198). 3 patients presenting during the Pandemic had covid-19 swabs prior to admission and 10 had attended primary care services. Number of days between onset of malaria symptoms and presentation to the Emergency Department Box plot demonstrating that patients were waiting longer post symptom onset to access care in the Emergency Department. 3 patients had covid swabs in the community and 10 accessed care through their primary care physician. Conclusion Our data show that malaria is being considered early in the emergency department however there remain significant delays in administration of treatment. In 6 cases where malaria was not considered early there were delays in diagnosis of up to 5 days. An audit cycle will be completed with the aim of reducing door to antimalarial time. Disclosures All Authors: No reported disclosures

Topic: Malaria Research and Control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Responsiveness of the trimmed rat subcutaneous adipose tissue beta-receptors to catecholamines in ontogenesis.

In order to estimate the possible changes of the functional state of beta-adrenergic receptors during ontogenesis, the lipid mobilizing effects of isoprenaline (ISO), adrenaline (ADR) and noradrenaline (NA) were studied in trimmed subcutaneous adipose tissue of rats at different stages of postnatal development (5, 14, 21 and 35 days after birth. The release of free acids (FFA) into the incubation medium was measured after addition of increasing concentrations of catecholamines and the dose-response curves were evaluated. In all the studied age groups, ISO produced the highest maximum effect and had the greatest potency. The calculated pD2 values indicate the same potency order ISO much greater than NA = ADR in all age groups and they also demonstrate that there exist no appreciable differences in the affinity single catecholamines at different stages of postnatal development. In comparison with all the other groups, the intrinsic activity of the studied adrenomimetics was relatively low in 14-day-old rats.

Topic: Adipose Tissue and Metabolism
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Remediation and Intermediality: From Moving to (Film) Still

It is safe to say that the preferred mode of artistic engagement with Hitchcockian cinema involves film and video. In many of these, the original film is cut, spliced, reedited, slowed down, sped up, stilled, or copied.1 Despite these interventions, we are still able to recognize the source material, to identify Vertigo (1958), Psycho (1960), or The Birds (1963) in these works. Even in the case of Girardet and Müller's The Phoenix Tapes (1999), which disperses compendiums of clips across the gallery space or Baldessari's Tetrad Series (1999), which offers us only a portion of a film still in conjunction with other images and text, there remains a close medial and indexical connection to the original films from which these fragments have been excised. In certain instances, the preservation of the original in some form attests to artists' desires for Hitchcock to continue to speak for himself. As noted in the previous chapter, Matthias Müller sees The Phoenix Tapes as a "collaboration" between himself, Girardet, and Hitchcock. This approach reflects the kind of collaborative impulse Fowler detects in much contemporary cinematic artwork.2 It is a form of collaboration that is often borne out of a cinephilic admiration and an artistic urge to maintain, on some level, the integrity of the filmic text. It is an impulse to commit acts of creative intervention that do not, to the artists' minds, threaten Hitchcock's cinematic vision or corrupt the sanctity of a Hitchcock film.KeywordsVideo GameGame PlayAesthetic OperationRear WindowFilmic TextThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Topic: Visual Culture and Art Theory
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Changes in disaccharide composition of heparan sulphate fractions with increasing degrees of sulphation

Heparan sulphate by-products from the commercial manufacture of pig mucosal heparin were freed of chondroitin sulphate and fractionated according to anionic density. The fractions were treated with HNO2 at pH 1.5, and the resulting mixtures of oligosaccharides were reduced with NaB3H4 and analysed for their disaccharide composition by paper chromatography and by high-pressure liquid chromatography. The results show that the molar ratio of 2-O-sulpho-alpha-L-iduronosylanhydromannose to 6-O-sulpho-(2-O-sulpho-alpha-L-iduronosyl)anhydromannose decreased from 2.5 to 0.04 as the degree of sulphation of the fractions increased. In contrast, the molar ratio of 6-O-sulpho-(beta-D-glucuronosyl)anhydromannose to 6-O-sulpho-(alpha-L-iduronosyl)anhydromannose was approx. 2.4 in all heparan sulphate fractions and decreased to only half of this value in the most highly sulphated heparin fractions. These results are consistent with biosynthetic studies, which have shown that the N-sulpho-(2-O-sulpho-alpha-L-iduronosyl)D-glucosamine disaccharide is the metabolic precursor of the NO-disulpho-(2-O-sulpho-alpha-L-iduronosyl)-D-glucosamine disaccharide in heparin biosynthesis. The high-pressure liquid chromatography of the heparan sulphate oligosaccharides also revealed a number of unidentified oligosaccharides in the deamination mixtures.

Topic: Proteoglycans and glycosaminoglycans research
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Processing of (PyC/TiC)<sub>n</sub> multilayered coatings by pulsed CVD and RCVD

Pyrocarbon/titanium carbide (PyC/TiC) n multilayered coatings have been deposited on carbon substrates by P-RCVD which is a combination of pulsed chemical vapour deposition (P-CVD) with reactive CVD (RCVD).From thermodynamic calculations, a thin TiC sublayer deposited between two PyC sublayers should be stoichiometric.TiC and PyC growth rates have been investigated, as well as PyC consumption occurring during carbide growth by P-RCVD.Hence, this process allows to achieve a sharp control of each sublayer thickness.Furthermore, it seems possible to totally consume the PyC intercalated between adjacent carbide sublayers in order to obtain a multilayered carbide (TiC) n .This method has been achieved to carbon fibre coating.The very first mechanical tests carried out on coated fibres are encouraging.The next step of this work lies in the study of such sub-micrometric coatings as interphases in ceramic matrix composites.

Topic: Metal and Thin Film Mechanics
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Galangal and ginger essential oils exerted microbial growth inhibitory activityand preservation potential on tofu

Galangal and ginger are commonly used as spices. Interestingly, their antimicrobial activity has been reported against a wide array of microorganisms. This study aimed to evaluate the effects of essential oils of galangal and ginger on the microbial growth, physical characters, and preservation potential on tofu during 8-day storage at room temperature. The essential oils were prepared by steam-and-water distillation method, and their constituents were analyzed by Gas Chromatography-Mass Spectroscopy (GC-MS). The microbial growth on the tofu was evaluated by the indirect enumeration method. The physical characters of tofu were organoleptically observed. The preservation potentials were calculated based on the changes in tofu physical characters relative to the negative control. The main constituents of galangal essential oil were 1,8-cineole, β-farnesene, and α-pinene, while those of ginger were geranyl acetate, 1,8-cineole, and camphene. Galangal essential oil significantly inhibited microbial growth, maintained the texture of tofu until day eight, and exerted preservation potential for four days. The same preservation effect was shown by ginger essential oil at 6.26 mg/mL, however it generated a weaker microbial growth inhibitory activity and resulted in the unfavorable texture on tofu. Hence, galangal essential oil is a suitable candidate to be developed into a natural food preservative.

Topic: Essential Oils and Antimicrobial Activity
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Mahdi Adamu and A. H. M. Kirk-Greene (eds.), Pastoralists of the West African Savanna, International African Seminars, New Series, No. 2, Manchester: Manchester University Press for the International African Institute, 1986, 391 pp., £35, ISBN 0 7190 2200 2.

Mahdi Adamu and A. H. M. Kirk-Greene (eds.), Pastoralists of the West African Savanna, International African Seminars, New Series, No. 2, Manchester: Manchester University Press for the International African Institute, 1986, 391 pp., £35, ISBN 0 7190 2200 2. - Volume 58 Issue 1

Topic: African history and culture analysis
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Effectiveness of a Canal Brush on Removing Smear Layer: A Scanning Electron Microscopic Study

This study evaluated the effectiveness of a highly flexible endodontic brush made of polypropylene canal brush (CanalBrush; Coltène) on smear layer removal from the canal walls when used according to the manufacturer's recommendations. Forty-four single-rooted mandibular incisors were prepared to apical size 30/0.06 and randomly divided into three groups A, B and C, where the final irrigation regimen was 10 mL 17% EDTA and 10 mL 2.5% NaOCl for group A, 10 mL EDTA, 5 mL NaOCl, CanalBrush for 20 s at 450 rpm and 5 mL NaOCl for group B, 10 mL NaOCl, CanalBrush and 10 mL NaOCl for group C. One medium-sized CanalBrush was used for each root canal and all brushes were examined under the optical microscope after application to evaluate bristle deformation. Afterwards, roots were split longitudinally and the presence of smear layer was evaluated under a scanning electron microscope. Used brushes invariably exhibited bristle deformation. Group C exhibited the highest means of smear layer in all thirds. Comparing the apical thirds in all groups, there was no statistical difference between groups A and B (3.64±0.48 and 3.68±0.62 respectively), while group C exhibited significantly higher scores (3.9±0.28) than the other two groups. In conclusion, the CanalBrush proved unable to remove smear layer from the instrumented root canals, when used according to the manufacturers' instructions.

Topic: Endodontics and Root Canal Treatments
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Evaluation of the biological activity of unmodified synthetic eel calcitonin rectal capsules. Comparison with intramuscular administration and placebo.

Biological activity of eel calcitonin 100 IU administered by the rectal route was evaluated in healthy volunteers by measuring plasmatic variations of cyclic adenosine monophosphate (cAMP) after a single dose and during a 21-day treatment. This formulation appears to allow a bioavailability of the drug which is half of the same dose administered intramuscularly, and to cause a prompt and significant increase of plasma cAMP, with minimal variations of calcaemia. Repeated administration shows the persistence in time of this effect. The overall conclusion is that the amount of calcitonin absorbed through the rectal mucosa seems sufficient to induce a typical biological response related to the interaction of the hormone with its specific receptors in bone.

Topic: Vitamin K Research Studies
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
The Knutson Index of the representation ring

In this paper, we study if, for a given simple module over a Hopf algebra, there exists a virtual module such that their tensor product is the regular module. This is related to a conjecture by Donald Knutson, later disproved and refined by Savitskii, stating that for every irreducible character of a finite group, there exists a virtual character such that their tensor product is the regular character. We also introduce the Knutson Index as a measure of Knutson's Conjecture failure, discuss its algebraic properties and present counter-examples to Savitskii's Conjecture.

Topic: Algebraic structures and combinatorial models
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Abstract 14672: Regulation of Succinate Signaling and Immunometabolism in Diabetes-Associated Atherosclerosis by Microrna-369-3p

Introduction: The risk of atherosclerotic cardiovascular disease (ASCVD) is increased in people with diabetes. Diabetes (D) is associated with impaired metabolism and functionality of macrophages (Mps), resulting in chronic inflammation. Identifying factors to combat metabolic alterations and promote resolution of inflammation remains an unmet goal. microRNAs (miRs) orchestrate multiple signaling events in Mps and regulate inflammation. Hypothesis: miR-369-3p regulates metabolic reprogramming in Mps during diabetes-associated atherosclerosis (D-AS). Methods and Results: miRNA-seq profiling from aortic intimal lesions of LDLR-/- mice on a high-fat sucrose containing (HFSC) diet revealed miR-369-3p downregulation with D-AS progression. miR-369-3p was also downregulated in PBMCs derived from D and D-associated ASCVD patients. Cell-type profiling showed miR-369-3p enrichment in mouse bone marrow derived Mps (BMDMs). oxLDL-stimulated BMDMs (foam cells, FCs) resulted in marked downregulation of miR-369-3p, increased secretion of IL1-β, and metabolic shift of oxidative phosphorylation (OXPHOS) to glycolysis, while miR-369-3p overexpression (miR-369-3p O/E) favored OXPHOS over glycolysis and reduced IL1-β secretion. Metabolomics revealed succinate, a key immunometabolite was profoundly elevated extracellularly from FCs, while miR-369-3p O/E reversed this phenotype. Extracellular succinate activates its receptor, GPR91. Indeed, GPR91 was upregulated in FCs while miR-369-3p O/E significantly repressed GPR91. 3’UTR luciferase reporter assay confirmed GPR91 as a miR-369-3p target. miR-369-3p O/E dampened GPR91-mediated inflammasome activation and mitochondrial dysfunction in FCs by decreasing p-ERK, p-DRP1, and NLRP3. Therapeutic delivery of miR-369-3p in LDLR-/- mice fed HFSC diet for 12 weeks reduced plaque size by ORO staining and plasma IL1-β. Flow cytometry of aortic Mps revealed that miR-369-3p decreased GPR91 expression by ~50%, along with a decrease in M1 and increase in M2-like-Mps. Conclusions: miR-369-3p confers a pro-resolving role in regulating lipid-driven inflammation and metabolic rewiring in Mps via targeting GPR91 and preventing D-AS plaque progression.

Topic: MicroRNA in disease regulation
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The investigation of Orthoptera from Huagaoxi Nature Reserve of Sichuan, China

We conducted a survey for Orthoptera in the Huagaoxi Nature Reserve of Sichuan for the first time during the summer of 2013. The result deals with 22 genera 35 species of superfamily Tettigonioidea, 10 genera 11 species of superfamily Acridoidea, and 14 genera 20 species of family Gryllidae, 1 genus 1 species of family Gryllotalpidae. In addition, Gampsocleis sinensis (Walker, 1871) is one newly recorded species of Sichuan.

Topic: Orthoptera Research and Taxonomy
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
MICROPATTERNABLE ELASTIC CARBON NANOTUBE/PDMS ELECTRETS

This paper reports the fabrication and performance of an elastic electret based on polydimethylsiloxane (PDMS)/carbon-nanotube (CNT) composites. The composite formulation concentrates CNTs near the surface of the PDMS and thereby combines the excellent electrical properties and room- temperature micropatternability of the CNT with the elasticity of PDMS. The material was corona-charged and the charge storage behavior was characterized using surface potential measurements. Substantial improvements in charge storage capacity and stability were observed compared to either pure PDMS or CNTs on the surface of PDMS at room temperature over a 280 hour measurement period.

Topic: Advanced Sensor and Energy Harvesting Materials
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
On the link between weather regimes and energy shortfall during winter for 28 European countries

Increasing the proportion of energy generation from renewables is one of the necessary steps towards reducing greenhouse gas emissions. However, renewable energy sources such as wind and solar are highly weather sensitive, leading to a challenge when balancing energy demand and renewable energy production, and therefore in managing energy shortfall. Identifying periods of high shortfall, here defined as when electricity demand significantly exceeds production by renewables, and understanding how these periods are affected by weather, is therefore critical. We use a previously constructed energy dataset derived from reanalysis data for a fixed electricity system to analyse the link between weather regimes and periods of high shortfall during the boreal winter for 28 European countries. Building on previous work we provide a perspective spanning from the subcontinental scale to individual countries. For each country we identify days with critical energy conditions, focusing on those with high energy demand, low production from wind and solar, and high energy shortfall. We show that high shortfall is more driven by demand than by production in countries with colder climates or less installed wind generation capacity, and is more driven by production than by demand in countries with warmer climates or more installed wind generation capacity. Of the six North Atlantic weather regimes considered here, only a subset are found to favour the occurrence of high shortfall days. In particular, blocking-type weather regimes affect large parts of Europe, suggesting that shortfall days can occur across multiple countries simultaneously. Furthermore, if a subset of countries experience shortfall days, neighbouring countries have a higher likelihood of also experiencing shortfall days. Motivated by this result, we examine the hypothetical impact the coldest European winter of the 20th century, 1962/63, would have had on the present-day energy system. It is found that the persistent blocking conditions associated with that winter, if they occurred today, would lead to higher demand and shortfall across large parts of Europe during most of the winter, and would be extreme in this respect compared to other winters.

Topic: Climate Change Policy and Economics
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Ethical Concerns in Usability Testing Involving Older Adults

Based on experience from the research project “User Manuals for Older Adults”, this paper discusses whether there are special ethical concerns with older adults as test persons in a usability test involving the think-aloud method. In this context, older adults are defined as individuals with normal cognitive and physical problems of ageing. The paper concludes that usability testing is necessary as a part of the design cycle, but that special care can be taken to ensure that test persons do not feel disempowered during the test.

Topic: Technology Use by Older Adults
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences