jimnoneill/paper-to-field-training huggingface dataset:
Systematic analysis of the clinical and biochemical characteristics of maternally inherited hypertension in Chinese Han families associated with mitochondrial

Mitochondrial DNA mutations may be associated with cardiovascular disease, including the common cardiac vascular disease, hypertension. In this study we performed segregation analysis and systematically evaluated the entire mitochondrial genome in nine maternally inherited hypertension probands from Chinese Han families. We also performed clinical, genetic and molecular characterization of 74 maternally inherited members from these families and 216 healthy controls. In the maternally inherited members, 12 had coronary heart disease (CHD), six had cerebrovascular disease, five had diabetes, nine had hyperlipidemia and three had renal disease. Laboratory tests showed that the sodium and potassium levels in blood of the maternally inherited members were higher than those of the control group (P < 0.01), while no differences were observed in fasting blood glucose (FBG), total cholesterol (TC), triglyceride, low density lipoprotein cholesterol (LDL-c) and creatinine levels (P > 0.05). The high density lipoprotein cholesterol (HDL-c) level of the maternally inherited members was lower than that of the control group (P = 0.04). The whole mitochondrial DNA sequence analysis revealed a total of 172 base changes, including 17 in ribosomal RNA (rRNA) genes, four in transfer RNA (tRNA) genes, and 22 amino acid substitutions. The remainder were synonymous changes or were located in non-coding regions. We identified seven amino acid changes in the nine maternally inherited hypertension families, including four mutations in ATPase6 and three in Cytb. More interestingly, tRNASer(UCN) 7492 T > C was absent in controls and was present in <1% of 2704 mtDNAs, indicating potential functional significance. This study showed that mutations in mtDNA may contribute to the pathogenesis of hypertension in these Chinese Han families. In the near future, identification of additional mtDNA mutations may indicate further candidate genes for hypertension.

Topic: Mitochondrial Function and Pathology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Markers of Ovarian Cancer Using a Glycoprotein/Antibody Array

Abstract : Profiling of the glycan structures that differ between the serum of serous ovarian cancer and benign conditions have been performed using lectin array for biomarker studies. These arrays have used 16 different lectins which respond to specific glycan structural moieties of glycoproteins in patient serum. It has been found that there are distinct changes in the level of fucosylation between cancer and benign using LCA, AAL and UEA lectins which detect both core and outer arm glycosylation. Some difference was also observed for SNA which detects 2,6 sialylation. Using these lectins we have been able to extract the glycoproteins from patient serum and have evaluated the differentially expressed glycoproteins based on mass spec and glycoarray technologies. We have identified 10-12 glycoproteins which show distinct changes in expression between benign conditions, normals, early stage ovarian cancer and stage 3c serous ovarian cancer. These glycoproteins have been used for further blinded validations using a limited set.

Topic: Glycosylation and Glycoproteins Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Digital Twin Based Remote Resource Sharing in Internet of Vehicles using Consortium Blockchain

With the evolving Internet of Vehicles (IoVs), the onboard resources of vehicles in computing and communication are experiencing fast growth. The sharing of road information and computing results among vehicles in proximity can effectively improve the utility of IoVs. However, remote inter-vehicular resource sharing, e.g., information and computing resource sharing, remains an under-explored issue. Motivated by this, we propose a novel digital twin based fair trading platform built upon consortium blockchain to enable city-wide vehicular resource sharing. Specifically, we first develop a digital twin based vehicular platform to enable vehicular resource sharing in the cloud. To track and secure the resource sharing among digital twins, the consortium blockchain is deployed, which is enforced by the designed smart contracts with an efficient Proof-of-Stake (PoS) consensus algorithm. In addition, an innovative incentive mechanism is devised to motivate the city-wide resource sharing for vehicles, which can maximize the profits of task publishers. Using extensive evaluations, we show the effectiveness of the proposed system.

Topic: Blockchain Technology Applications and Security
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Dynamic Fluorescent Imaging of Human Immunodeficiency Virus Type 1 Gag in Live Cells by Biarsenical Labeling

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Gag is the primary structural protein of the virus and is sufficient for particle formation. We utilized the recently developed biarsenical-labeling method to dynamically observe HIV-1 Gag within live cells by adding a tetracysteine tag (C-C-P-G-C-C) to the C terminus of Gag in both Pr55 Gag expression and full-length proviral constructs. Membrane-permeable biarsenical compounds FlAsH and ReAsH covalently bond to this tetracysteine sequence and specifically fluoresce, effectively labeling Gag in the cell. Biarsenical labeling readily and specifically detected a tetracysteine-tagged HIV-1 Gag protein (Gag-TC) in HeLa, Mel JuSo, and Jurkat T cells by deconvolution fluorescence microscopy. Gag-TC was localized primarily at or near the plasma membrane in all cell types examined. Fluorescent two-color analysis of Gag-TC in HeLa cells revealed that nascent Gag was present mostly at the plasma membrane in distinct regions. Intracellular imaging of a Gag-TC myristylation mutant observed a diffuse signal throughout the cell, consistent with the role of myristylation in Gag localization to the plasma membrane. In contrast, mutation of the L-domain core sequence did not appreciably alter the localization of Gag, suggesting that the PTAP L domain functions at the site of budding rather than as a targeting signal. Taken together, our results show that Gag concentrates in specific plasma membrane areas rapidly after translation and demonstrate the utility of biarsenical labeling for visualizing the dynamic localization of Gag.

Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
A decision aid for milk tanker run allocation

This paper reports on a decision aid that recommends solutions to a particular vehicle allocation problem occurring in the New Zealand dairy industry. The decision aid has been developed for use by New Zealand milk tanker schedulers. It is designed to aid them in the allocation of tankers to milk collection routes in order to alleviate pumping bay congestion, which occurs when the tankers return to unload milk at a processing plant. It enables its users to remain in control of the tanker allocation process, while using their own experience and preferences. The paper describes the issues involved and the type of help that the schedulers need. It introduces a typical allocation problem and describes some heuristics for its solution, which are incorporated in the decision aid.

Topic: Agricultural Economics and Policy
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Pickering Emulsions Stabilized by Nanoparticles with Thermally Responsive Grafted Polymer Brushes

A study is presented of emulsification by silica nanoparticles with poly(2-(dimethylamino)ethyl methacrylate) brushes grafted from their surfaces (SiO&lt;sub&gt;2&lt;/sub&gt;−PDMAEMA) by atom-transfer radical polymerization (ATRP). The grafted nanoparticles were used to stabilize xylene-in-water and cyclohexane-in-water Pickering emulsions. PDMAEMA is a water-soluble weak polyelectrolyte with a pH-dependent lower critical solution temperature (LCST). Accordingly, SiO&lt;sub&gt;2&lt;/sub&gt;−PDMAEMA nanoparticles were thermally responsive, as shown by the fact that they displayed a critical flocculation temperature (CFT) when heated. ATRP provides a high degree of control over the brush grafting density and degree of polymerization, two of the principal variables examined in this study. The effects of the solvent quality of the “oil” for the PDMAEMA brush were studied in addition to the effects of aqueous pH, ionic strength, and temperature relative to the CFT. The preferred emulsion type was oil in water in all cases. The lowest grafting density particles (0.077 chains/nm&lt;sup&gt;2&lt;/sup&gt;) proved to be the most efficient and robust emulsifiers, producing stable emulsions using as little as 0.05 wt % particles in the aqueous phase and successfully emulsifying over a broader range of solution conditions than for the higher grafting density particles (0.36 and 1.27 chain/nm&lt;sup&gt;2&lt;/sup&gt;). Both good (xylene) and poor (cyclohexane) solvents could be emulsified, but the poor solvent could be emulsified over a broader range of conditions than the good solvent. Emulsions have been stable for over 13 months, and some have dispersed as much as 83 vol % oil in the emulsion phase. Thermally responsive emulsions were created with the SiO&lt;sub&gt;2&lt;/sub&gt;−PDMAEMA particles such that stable emulsions prepared at low temperature were rapidly broken by increasing the temperature above the CFT.

Topic: Pickering emulsions and particle stabilization
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Theoretical Investigation of Gasification of Solid Fuel in a Low-Temperature Gas Generator of an Aircraft

The mathematical model and numerical method proposed in this study make it possible to study the regularities of gasification of solid porous fuel when hot gases are filtered through it and estimate the maximum operating time of the propulsion system. The features of gasification are studied for the case when polymethyl methacrylate is used as a solid fuel. It is shown that by changing the characteristics of the system and the process conditions, it is possible to change the flow rate of gaseous products from the gas generator, which will affect both the operating conditions of the cooling system for the materials of the combustion chamber structure and the value of the engine thrust. It is also shown that the operating time of a jet engine with a low-temperature gas generator increases with decreasing temperature and consumption of gaseous solid fuel combustion products, the interphase heat transfer coefficient, and the characteristic pore size of the fuel.

Topic: Rocket and propulsion systems research
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Platycarpha parvifolia (166326)

<b>Kingdom: </b>Plantae<br><b>Division: </b>Magnoliophyta<br><b>Class: </b>Eudicots<br><b>Order: </b>Asterales<br><b>Family: </b>Asteraceae<br><b>Scientific name: </b>Platycarpha parvifolia S.Moore<br><b>Specimen barcode: </b>166326

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Accidental salicylate intoxication in a hemodialysis patient

• A 61-year-old woman receiving long-term hemodialysis presented with symptoms of tinnitus, insomnia, malaise, and disequilibrium. On close questioning, it was discovered that she had received a prescription for salsalate (Disalcid) from a consulting physician who had evaluated her for joint pain. This tablet was similar in appearance to a dried aluminum hydroxide gel preparation (Alu-tab) that the patient was taking as a phosphate binder. She had mistakenly been taking six Disalcid tablets with each meal. Her salicylate level was 5.86 mmol/L, but she had no change in her serum electrolyte levels or acid-base status. When the salsalate treatment was stopped and regular dialysis treatments were continued, the symptoms of salicylism resolved. This case illustrates one of the potential dangers of polypharmacy in patients with chronic disease. The mild course was probably due to ongoing hemodialysis, which prevented the appearance of the usual acid-base abnormalities of salicylate intoxication. (<i>Arch Intern Med</i>1988;148:2277-2278)

Topic: Poisoning and overdose treatments
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Polyphasic Approach to Fungal Taxonomy

The taxonomy of micromycetes always experienced a number of specific problems. The development of molecular phylogeny in the last two decades became an important achievement for fungal taxonomy. The use of multilocus sequencing combined with phylogenetic analysis seems to be the most convenient and reasonable in the methodological aspect for species delimitation within the frames of the evolutionary species concept, which is the most popular among mycologists now and, obviously, will remain popular in the nearest future. The most proper tool for species delimitation is phylogenetic species recognition. However this well-developed approach sometimes allows neither a clear recovery of the structure of biodiversity nor the easy identification of taxa. The so-called polyphasic taxonomy concept arose in the 1970s among bacteriologists; it also became quite popular in mycology in the 2000s. Nowadays, it is considered as consensus taxonomy, i.e., a definition of taxa based on a comparative analysis of all available traits. This review describes the process of the formation of the polyphasic approach and the modern practice of its application in mycology. A special part of the review examines the diversity of traits available for a mycologist and the expediency of their use in taxonomy, in particular, within the limits of the polyphasic approach. It is concluded that this approach is reasonable when phylogenetic recognition provides no satisfactory results (e.g., in the case of a small number of sequenced genes or the analysis of recently diverged species). In additional, the polyphasic approach is suitable for the formation of taxonomic hypotheses that will be examined with phylogenetic methods and that can be further used as a basis to form the appropriate strain samplings.

Topic: Plant Pathogens and Fungal Diseases
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Play for Today: A Statistical History

This article presents an original statistical analysis of Play for Today (BBC1, 1970–84). It begins by defining what counts as a Play for Today. It then presents six specific data-sets examining the following: (1) the output of Play for Today in different periods; (2) the duration and scheduling of plays; (3) their originality; (4) the use of film or video; (5) audience viewing figures; and (6) the number of television repeats. It also compares the data to indicate the construction of a privileged Play for Today canon which ignores a large ‘lost continent’ of Plays for Today.

Topic: Cultural Industries and Urban Development
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
ChemInform Abstract: Isolation of Inhibitors of TPA‐Induced Mouse Ear Edema from Hoelen, Poria cocos.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Natural product bioactivities and synthesis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Imagery Techniques in Psychiatry

Hypnagogic or imagery is not an uncommon phenomenon; it is based on preconscious, preverbal thinking in pictures and characterized by symbol-content, changing thematic scenes, motion, color perception, relative autonomy, and affective connotations. Integrated with established dynamic principles and competently used, imagery techniques are regarded as a worthwhile addendum to the diagnostic-therapeutic armamentarium of the dynamically trained therapist for exploration and therapy of neurotic conflicts and related emotional difficulties. A brief historical overview and primer on the topic is presented along with a concise procedural outline of one established clinical method (Leuner's), a didactic approach used by the author, and a discussion of some theoretical questions implied in these approaches.

Topic: Academic and Historical Perspectives in Psychology
Subfield: General Psychology
Field: Psychology
Domain: Social Sciences
Drawings from a Dying Child

Drawings from a Dying Child concerns a young girl, Rachel, terminally ill with leukaemia. The book describes a series of drawings she made and shows how they reveal her inner experience, how she became fully aware that she was dying and even came to accept death. The result is a moving and informative story that will be invaluable to caregivers and families with a dying child. It provides new understanding of the experience of a dying child and suggests practical strategies for coping.

Topic: Child Therapy and Development
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Weichselian red tills in the Gardno Phase End Moraine (Dębina Cliff) – criteria for distinction, origin and stratigraphic position, and implications for the origin and course of the Baltic Ice Stream

Abstract. The paper presents the results of investigations of red tills from the South Baltic Middle Sea-Coast recorded in cliff exposures of Gardno Phase End Moraine. Distinctive features of these tills are: high percentage of Aland granitoids and porphyries identified in the 16-32 mm fraction, and large amounts of non-carbonate rocks, mostly red feldspars in relation to quartz, in the sandy fractions of 0,5-0,8 mm and 2-4 mm. Based on structural-textural features, the red till has been classified as flow till of local origin. The ice dynamism during Gardno Phase can be correlated with the Young Baltic Advance and most probably with the Belt Sea advance. On the basis of the petrographic properties of the Gardno red till and the results of radiocarbon dating, a new hypothesis regarding the origin, chronology and rate of flow of the Baltic Ice Stream is developed.

Topic: Geological Formations and Processes Exploration
Subfield: Geophysics
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Some effects of different maskers on psychophysical performance in discrimination and detection tasks

Psychophysical performance was measured in a number of different tasks in order to compare performance under different masking conditions. With the noise masker set to provide a given amount of masking, frequency discrimination of a 4-kHz tone was shown to be worse in a lowpass noise than in a wideband noise. Discrimination of the intensity of the tone under these two masking conditions was comparable except at the lowest level of tone. Finally, the growth of detectability with level was measured in a detection task, with a greater slope being found in lowpass noise than in wideband noise. The results are discussed in light of the differences in physiological responses observed under similar masking conditions.

Topic: Noise Effects and Management
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
RESUME SUMMARY

Introduction: L’esthésioneuroblastome est une tumeur maligne rare des fosses nasales. Il s’agit d’une tumeur agressive et récidi-vante dont le traitement est controversé. Notre objectif est de décrire les particularités diagnostiques et les actualités thérapeutiques de cette tumeur. Matériels et méthode: Etude rétrospective sur une période de 10 ans (2001-2010), ayant intéressé trois cas d’esthésioneuroblas-

Topic: Head and Neck Surgical Oncology
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Ultrasound-guided percutaneous drainage of deep neck abscesses

Deep neck abscesses may still result in significant morbidity and mortality. Surgical therapy carries the risk of damage to cranial nerves and arteries. Excellent results of ultrasound-guided percutaneous catheter drainage of abdominal abscesses led us to apply this technique to the management of deep neck abscesses. Five patients were treated with ultrasound-guided catheter drainage and antibiotics. All patients were cured without complications or recurrences. We consider this cheap and highly effective treatment as a valuable alternative to conventional therapy.

Topic: Otolaryngology and Infectious Diseases
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Development of Nd-doped optical gain material based on silica glass with a high thermal shock parameter for high-average-power laser

This paper reports demonstrations of laser amplification and oscillation at 1.06 /spl mu/m in a bulk-type Nd-doped silica glass (Nd/sub 2/O/sub 3/: 1.25 wt%, Al/sub 2/O/sub 3/: 2.72 wt%, SiO/sub 2/: 96.03 wt%) with a high thermal shock parameter, 12.0 W/cm.

Topic: Solid State Laser Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
A New Access Site Management Tool: The Angio-Seal™ Hemostatic Puncture Closure Device

Purpose: Given the increasing number of percutaneously applied endovascular therapies, the incidence of access-related vascular complications can be expected to rise, particularly in association with those techniques requiring large sheaths or anticoagulation. The need exists for a safe, easy to use, and effective hemostatic technique to replace the labor-intensive method of manual compression. Methods: A bioabsorbable, sheath-delivered vascular closure device (Angio-Seal™) has been developed that deposits a small collagen plug within the arterial wall to mechanically seal the puncture defect. An anchor connected by suture to the plug is first deployed in the arterial lumen and pulled flush against the interior arterial wall to guard against intraluminal deposition of the collagen. Results: The Angio-Seal device was deployed successfully in 80 (96%) of 83 attempts involving common femoral arteries accessed for peripheral angioplasty (n = 30), coronary angiography (n = 30), and coronary angioplasty (n = 16). Three popliteal artery access sites and one femoropopliteal bypass graft were also treated. Hemostasis was immediate in 78 cases (98%); 2 sites required a 5-minute manual compression to effect a secure seal. Three devices failed to deploy, and manual pressure was used to close the puncture. Nondeployment did not cause any sequelae, and no complications were encountered with the technique. Conclusions: This novel vascular closure device is quick (&lt; 1 minute application time) and simple to use, providing a positive seal of common femoral artery puncture sites for both peripheral and coronary interventions. It appears to be a reliable alternative to standard manual hemostasis.

Topic: Vascular Procedures and Complications
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences