jimnoneill/paper-to-field-training huggingface dataset:
From Centralized to Decentralized Resilience: Projected Climate Impacts on Mozambique's Energy-Water Nexus and a Framework for Adaptation

<title>Abstract</title> Mozambique's energy security, heavily reliant on climate-vulnerable hydropower, faces severe threats from global warming. While current planning often focuses on reinforcing centralized infrastructure, this strategy fails to address underlying socioeconomic vulnerabilities. This study argues that tackling this vulnerability requires a major strategic pivot towards decentralized, equitable adaptation. We conduct an integrated assessment, making three key contributions: (1) Using high-resolution (BCC-CSM2-MR, CMIP6) simulations under four SSP scenarios, we project significant regional warming of 1.2–5.2°C by 2100, with the most severe increases in the south. (2) We develop a novel socio-climatic vulnerability index, combining climate and socioeconomic data to identify risk hotspots. This index reveals southern Mozambique as the highest-risk region (VI = 0.72) due to extreme exposure, high sensitivity, and moderate adaptive capacity. (3) We assess adaptation strategies through a multi-criteria framework, showing that decentralized solar photovoltaic (PV) systems are the most robust option, offering significant co-benefits for equity and Sustainable Development Goals (SDGs). Our results stress that solving Mozambique's energy vulnerability necessitates a fundamental shift from reinforcing centralized infrastructure to supporting decentralized, fair adaptation. The integrated assessment framework presented offers a transferable model for diagnosing socio-climatic vulnerability in other regions reliant on centralized, climate-vulnerable energy systems.

Topic: Water-Energy-Food Nexus Studies
Subfield: Water Science and Technology
Field: Environmental Science
Domain: Physical Sciences
Families' self-interest and the cadaver's organs. What price consent?

IT IS TRAGIC for an eligible recipient to die for want of a lifesaving organ. The profession and society are under a clear moral compulsion to seek ways to prevent such deaths. But it would be equally tragic, even in order to save lives, to resort to such a morally dubious and destructive policy to increase the supply of donated organs as Peters suggests. His proposal that a $1000 death "benefit" be offered to motivate families to consent to removal of organs from their deceased relatives is logically, ethically, and practically flawed. In his sincere and understandable commitment to save lives, Peters follows an oversimplified line of reasoning: people die waiting for organ transplants. Organs are scarce because we have relied on altruism to motivate donors. Therefore, self-interest must replace altruism as a motive. With the obstacle of activism out of the way, Peters believes that an adequate supply, and

Topic: Organ Donation and Transplantation
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Before Revelation: The Rabbis, Paul,

I. STRETCHING THE PARAMETERS OF JEWISH-CHRISTIAN DIALOGUE The recent experience of theological dialogue between Jews and Christians has convinced many (but not all) of the participants that significant things can be said to each other only when faith is explicit.' A significant dialogue can take place, but it is hard. It would seem to be especially hard when the Christian partner in dialogue is under the strong influence of Karl Barth. For other forms of Christian theology-Thomism, Process theology, Tillichian theology, Niebuhrian theology, for exampleconstitute a realm of nature or being or experience, one that is distinguishable from the singularity of Christian (and Jewish) revelation, a realm where Jews and Christians (and possibly others) can come together as equals. But Karl Barth and his disciples seem vigorously to deny any such possibility, let alone any such reality. This would seem to be the case because Barth often claims to confine all of Christian doctrine within the singularity of christological revelation. Since Jews cannot accept the ultimate christological claim any more than Christians can accept the ultimate claim of the Law, it would seem there is no logos from which authentic dia-logue between Jews and Christians can be constituted.2

Topic: Religion, Theology, History, Judaism, Christianity
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Ectopic pituitary adenoma associated with an empty sella presenting with hearing loss: case report with literature review

Ectopic pituitary adenomas are uncommon entities that may pose substantial diagnostic challenges. In the majority of these cases, patients present with endocrine and/or nasal obstruction symptoms. We report the case of an ectopic pituitary adenoma in a 76-year-old man with an empty sella who initially presented with right-sided hearing loss progressing to bilateral hearing loss over the next 4 years. Neuroimaging studies revealed a large, expansile central skull base mass replacing the clivus and sphenoid sinus, and invading the internal auditory canals and inner ear bilaterally. The tumor also involved the floor of the middle cranial fossae and bilateral medial temporal and occipital bones. Histopathologic examination, including immunohistochemical studies, revealed a sparsely granulated lactotroph adenoma. Hearing loss in a patient with ectopic pituitary adenoma constitutes an extremely unusual presentation. This case was further complicated by the presence of an empty sella and the absence of symptoms related to hyperprolactinemia.

Topic: Pituitary Gland Disorders and Treatments
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Experimental-Numerical Investigation of Rotor-Rotor Aerodynamic Interactions for eVTOL Aircraft Configurations

The paper presents the description of a research activity aimed to the systematic study of the rotor-rotor aerodynamic interaction with application to the flight conditions typical of eVTOL aircraft. The activity considers a dual effort, experimental and numerical, to gather systematic parametric data on different types of rotor-rotor interactions. In particular, the paper describes the planning and set up of a wind tunnel campaign aimed to evaluate the effects of the aerodynamic interactions on the rotor performance and flow field for two propeller models both in side-by-side and tandem configuration. Moreover, the results of numerical simulations performed with a mid-fidelity aerodynamic code on both the planned test configurations are presented showing the main effects of the aerodynamic interactions on the performance of the propeller.

Topic: Aerospace Engineering and Control Systems
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Faculty Opinions recommendation of Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses mechanical force to enable vascular development. Here, we address Piezo1 in adult endothelium, the major control site in physical activity. Mice without endothelial Piezo1 lack obvious phenotype but close inspection reveals a specific effect on endothelium-dependent relaxation in mesenteric resistance artery. Strikingly, the Piezo1 is required for elevated blood pressure during whole body physical activity but not blood pressure during inactivity. Piezo1 is responsible for flow-sensitive non-inactivating non-selective cationic channels which depolarize the membrane potential. As fluid flow increases, depolarization increases to activate voltage-gated Ca2+ channels in the adjacent vascular smooth muscle cells, causing vasoconstriction. Physical performance is compromised in mice which lack endothelial Piezo1 and there is weight loss after sustained activity. The data suggest that Piezo1 channels sense physical activity to advantageously reset vascular control.The mechanisms that regulate the body's response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction. PMID: 28839146 Funding information This work was supported by: British Heart Foundation, United Kingdom Grant ID: FS/12/80/29821 Wellcome Trust, United Kingdom Medical Research Council, United Kingdom Grant ID: MR/L019051/1 Medical Research Council, United Kingdom British Heart Foundation, United Kingdom Grant ID: FS/14/22/30734

Topic: Erythrocyte Function and Pathophysiology
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Value-at-Risk and Tsallis statistics: risk analysis of the aerospace sector

In this study, we analyze the aerospace stocks prices in order to characterize the sector behavior. The data analyzed cover the period from January 1987 to April 1999. We present a new index for the aerospace sector and we investigate the statistical characteristics of this index. Our results show that this index is well described by Tsallis distribution. We explore this result and modify the standard Value-at-Risk (VaR), financial risk assessment methodology in order to reflect an asset which obeys Tsallis non-extensive statistics.

Topic: Complex Systems and Time Series Analysis
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Uncovering Potential lncRNAs and Nearby mRNAs in Systemic Lupus Erythematosus from the Gene Expression Omnibus Dataset

<b>Aim:</b> The aim of this study was to find potential differentially expressed long noncoding RNAs (lncRNAs) and mRNAs in systemic lupus erythematosus. <b>Materials & methods:</b> Differentially expressed lncRNAs and mRNAs were obtained in the Gene Expression Omnibus dataset. Functional annotation of differentially expressed mRNAs was performed, followed by protein-protein interaction network analysis. Then, the interaction network of lncRNA-nearby targeted mRNA was built. <b>Results:</b> Several interaction pairs of lncRNA-nearby targeted mRNA including <i>NRIR-RSAD2</i>, <i>RP11-153M7.5-TLR2</i>, <i>RP4-758J18.2-CCNL2</i>, <i>RP11-69E11.4-PABPC4</i> and <i>RP11-496I9.1-IRF7</i>/<i>HRAS</i>/<i>PHRF1</i> were identified. Measles and MAPK were significantly enriched signaling pathways of differentially expressed mRNAs. <b>Conclusion:</b> Our study identified several differentially expressed lncRNAs and mRNAs. And their interactions may play a crucial role in the process of systemic lupus erythematosus.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Engage Students with Feedback‐Driven Metacognition

Cognitive scientists have developed evidence-based recommendations for improving students' metacognition by incorporating frequent feedback. In order to examine metacognition scientifically, researchers ask students to make two types of ratings: judgments of learning (JOLs), and confidence judgments. The illusion of fluency and illusion of confidence are intertwined, and both illusions can be detrimental to student learning. If learning feels fluent, students may be overconfident in their own learning. Students' confidence-accuracy mismatches (incorrect answers with high confidence and correct answers with low confidence) can be remedied with feedback. The chapter presents specific recommendations for fostering metacognition based on a wealth of scientific research and years of classroom practice. Research in laboratories and classrooms indicate that metacognition can also be improved using Metacognition Sheets. With Metacognition Sheets, students make JOLs and/or confidence ratings during learning. By teaching the students to identify what they know and what they do not know, feedback-driven metacognition becomes a valuable Power Tool.

Topic: Innovative Teaching and Learning Methods
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
The Effect of the Quality of Sibling Relationships on the Life Satisfaction of Adults With Schizophrenia

OBJECTIVE: This study examined the importance of the quality of the sibling relationship to the life satisfaction of adults with schizophrenia. METHODS: Data were drawn from a longitudinal survey of aging families of adults with schizophrenia. Ninety-three dyads of adults with schizophrenia and their siblings participated. Participants independently completed a self-administered mail questionnaire. Data on the quality of the sibling relationship were taken from the siblings’ scores on the Positive Affect Index, and data on life satisfaction of the adult with schizophrenia were measured by the self and present life subscale of the Satisfaction With Life Scale. RESULTS: Adults with schizophrenia had higher levels of life satisfaction when their siblings reported having a closer and more supportive relationship with their sibling with schizophrenia. CONCLUSIONS: Our findings provide evidence of the saliency of the sibling relationship to quality of life of adults with schizophrenia in midlife.

Topic: Family Caregiving in Mental Illness
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Prescribing Pattern in Diabetic Outpatients in a Tertiary Care Teaching Hospital in Nepal

Background: Diabetes is a chronic disease associated with significant morbidity and mortality. Diabetics are at a higher risk of polypharmacy and more vulnerable to irrational prescription. Data regarding drug use pattern in diabetes is lacking in South Asian countries. Objectives: The present study was conducted with the objectives of collecting the demographic details of diabetes patients, studying the pattern of drug prescribing among diabetic outpatients, calculating the mean prescription cost for the diabetes patients and analysing the prescriptions according to prescribing indicators. Methods: A cross-sectional study was carried out at the Out-patient Pharmacy (OPP), Manipal Teaching Hospital, Pokhara, Nepal, from 22nd August to 7th December 2006. All the diabetes patients who visited the OPP during the study period were enrolled after getting verbal consent and interviewed by the researchers, based on the study objectives. The details were entered in the structured patient profile form, and the filled forms were analysed. Results: Altogether 182 patients, 103 males (56.59%) and 79 females (43.41%), were enrolled. Among these, 69 (37.91%) were in the age group 51–60 years, 128 (70.33%) had a diabetic history of less than 5 years and 136 (74.72%) had at least one concurrent illness. Two, three and four drugs were prescribed in 39 (21.43%), 35 (19.23%) and 40 (21.98%) patients, respectively. Altogether, 685 drugs were prescribed with an average of 3.76 drugs per prescription. Antidiabetics were accounted for 314 (45.84%) of the total drugs. Among the various antidiabetics, biguanides were accounted for 161 (51.27%) of the total antidiabetic medications. Among the study patients, 28 (15.38%) had an encounter with an injection prescribed and 16 (2.34%) of the total drugs were fixed-dose combinations and 0.88% (n = 6) of the drugs were antibiotics. The duration of prescription of medicines ranges from 29 to 35 days for 41.17% (n = 282) of the total drugs and 57 to 63 days for 44.23% (n = 303) drugs. Majority [650 (94.89%)] of the drugs were prescribed in oral dosage form. The average cost per prescription was NPR 1156.15 (US $16.17). Antidiabetic medications constituted 58.93% of the total cost. Among the antidiabetic medications insulin accounted for 41.07% of the total cost followed by biguanides (32.60%). Conclusions: Insulin and biguanides were the most commonly prescribed antidiabetics. Our study was done for a short period of time, and the number of patients studied was low. Hence, similar studies covering large number of patients

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Legal System and Practice of Guaranteeing Equal Rights of Persons with Disabilities in Various Countries

The guarantee of equal rights for persons with disabilities is a fundamental human right and a cornerstone of social progress. This paper conducts a comparative analysis of the legislative frameworks, implementation mechanisms, and challenges in protecting the rights of persons with disabilities in China, the United States, and the United Kingdom. The study reveals that while all three countries have established relatively comprehensive legal systems, significant differences exist in their implementation effectiveness. In China, the primary issues include inadequate enforcement of laws, insufficient funding, and persistent social prejudice and discrimination against persons with disabilities. In contrast, the United States and the United Kingdom demonstrate more robust mechanisms for implementation and greater social inclusivity in protecting the rights of persons with disabilities. Based on these findings, this paper proposes several innovative solutions, such as adopting a semi-public assistance system inspired by the UK, establishing employment support mechanisms for persons with disabilities, and introducing a trade-in policy to provide high-quality prosthetics at reduced costs. The research underscores the importance of strengthening international exchanges and cooperation, increasing financial investment, and raising social awareness to ensure the effective protection of the rights of persons with disabilities. Through these measures, the realization of equal rights for persons with disabilities can be further advanced, contributing to a more harmonious and progressive society.

Topic: Discrimination and Equality Law
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Phase II study of capecitabine (X) + docetaxel (T) as neoadjuvant treatment in patients (pts) with locally advanced breast cancer (LABC) including biological correlates

664 Background: X and T have demonstrated synergy in preclinical studies and survival benefits in metastatic BC. We aimed to determine whether the high efficacy of XT could translate into the neoadjuvant setting. Methods: Expression levels (mRNA) of 3 enzymes involved in X intratumoral activation and metabolism (thymidylate synthase [TS], thymidine phosphorylase [TP] and dihydropyrimidine dehydrogenase [DPD]), were determined in tumor biopsies before treatment and their relationship with clinical and pathological response analyzed using Fisher’s Exact Test. Pts with stage IIIA/IIIB LABC, adequate organ function and KPS ≥80 received 4 cycles of X 1250mg/m 2 (1000mg/m 2 for age &gt;60) bid d1–14 and T 75mg/m 2 d1 q3w followed by surgery, adjuvant AC q3w × 4 ± tamoxifen according to ER and PR status. The primary endpoint was pCR. Results: We enrolled 34 pts with LABC IIIA (44%)/IIIB (56%): median age 52y (30–72); KPS ≥90 (76%); median tumor size 6.8cm (2–20); N0 (20%), N1 (41%), N2/3 (35%); ER+PR-/p53+/HER2+ (23/24/28%). 128 cycles of X and T were administered (median 4, range 1–5). Main G3/G4 toxicities were: HFS 32%, diarrhea 15%, asthenia 9%, stomatitis 6% and neutropenia 71%. There were no treatment-related deaths. 2 pts were withdrawn prematurely due to adverse events. The overall response in 32 evaluable pts was 78%, including 5 CRs and 20 PRs. 6/29 pts evaluable for pathological response had pCR (20%), and 10 (33%) had ≤10mm residual tumor (3 microscopic RD) in breast. Nodal involvement after chemotherapy was N0 (33%), N1 (33%), N2 (27%), N3 (7%), and the rate of breast-conserving surgery was 17%. High TP/DPD ratio was associated with CR (p=0.037) and both high TP/DPD and low TS/DPD ratio appeared to correlate with residual tumor ≤10 mm (p=0.028). Conclusions: Neoadjuvant XT appears to be highly active. Safety was similar to that reported in anthracycline-pretreated pts but with less stomatitis. In this small sample, a high TP/DPD ratio appears to correlate with clinical response and a favorable enzymatic profile (high TP/DPD and low TS/DPD ratio) may predict for high pCR. A further prospective study is required to validate this hypothesis. No significant financial relationships to disclose.

Topic: Cancer Treatment and Pharmacology
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Occurrence Download

A dataset containing 40 species occurrences available in GBIF matching the query: { "and" : [ "TaxonKey is Nicotiana glauca", "Country is Tunisia", "HasCoordinate is true" ] } The dataset includes 40 records from 6 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0065253-250717081556266/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.

Topic: Agricultural pest management studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Control of Crystal Polymorphism by Tuning the Structure of Auxiliary Molecules as Nucleation Inhibitors. The β-Polymorph of Glycine Grown in Aqueous Solutions

The control of crystal polymorphism of the trimorphic crystals of glycine (Gly) grown in aqueous solutions in the presence of α-amino acids operating as stereospecific nucleation inhibitors is reported. The presence of enantiopure α-amino acids phenylalanine (Phe), methionine (Met), and tryptophan (Trp) in the crystallizing aqueous solutions induces changes in the morphology of α-Gly leading to the formation of pyramidal instead of bipyramidal crystals. Increased concentrations of racemic Phe and Met inhibit both the α- and β-polymorphs of glycine and induce precipitation of the thermodynamically most stable γ-polymorph. α-Amino acids that bear bulky side groups such as racemic tryptophan (Trp), N-CH3-Trp, and α-naphthylalanine induce precipitation of the least stable β-Gly polymorph. Quasi-racemic mixtures of R-Trp and S-Phe (or S-Met), for example, lead to the precipitation of one of the enantiomorphs of β-Gly. The roles played by the different α-amino acids in affecting morphology and polymorphism are discussed in terms of their interactions with and stereoselective occlusion in the various sectors of the {010} faces of the β-Gly crystals.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis

In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). The presence of zinc in the epidermis promotes epidermal homeostasis; hence, this study reviewed the role of zinc in the formation and function of the SC and TJs. Langerhans cells (LCs) are one of the antigen-presenting cells found in the epidermis. They form TJs with adjacent keratinocytes (KCs), capture external antigens, and induce antigen-specific immune reactions. Thus, the function of zinc in LCs was examined in this review. We also summarized the general knowledge of zinc and zinc transporters in the epidermis with updated findings.

Topic: Contact Dermatitis and Allergies
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences