jimnoneill/paper-to-field-training huggingface dataset:
Prototype of New Composite Weightage and Offset Thickness Design of Acetabular Cup in THR

Defect bone at hip joint of human body will required surgical operation which commonly known as Total hip replacements (THR). Succession rate of the surgical procedures depending
on many factors. Currently the THR operation could not guarantee 100% succession rate which dislocation, fracture, inflammation, edge-loading effect and rejection of new materials are among the concerned issues. The objective of this study particularly to make a prototype of new composite weightage and offsetting thickness of acetabular cup in order to increase the surgical post-operative succession rate. Firstly, a new design was drawn using SolidWorks software which the articulation area was offset by increasing the superior region. Then, the FE analysis conducted via ANSYS WORKBENCH to simulate the effect of offsetting the acetabular cup design. Secondly, a new material composition of Ep-UHMWPE with various weightage and thickness were studied experimentally according to ASTM D638-02A. Simulation and experimental analysis results show good agreement that 5mm thickness
improvise mechanical properties up to 66% in term of Von-Mises stress, total deformation and contact pressure. Thus, offsetting superior region thickness could potentially improvise the implant lifespan especially during the normal gait condition. Adding Ep (Epoxy) into existing material (UHMWPE) at ideal weightage also increasing the mechanical properties of the acetabular cup. However, further studies are required to design a second prototype with higher articulation efficiency and material’s biocompatibility.

Topic: Orthopaedic implants and arthroplasty
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Mixing of multiple coflowing confined laminar streams

The eigenvalues can now take on imaginary values, however the functions cf)m still comprise a complete orthogonal set. Although Eq. (Al) is apparently a solution to Eq. (3), it has two distinct disadvantages. It diverges slowly and, because its derivative with respect to x does not converge uniformly, it cannot be proven to satisfy the boundary conditions in Eq. (3). The following technique is, therefore, employed. Take the limit of Eq. (Al) with respect to time:

Topic: Fluid Dynamics and Turbulent Flows
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Generalized Multi-Output Gaussian Process Censored Regression

When modelling censored observations, a typical approach in current regression methods is to use a censored-Gaussian (i.e. Tobit) model to describe the conditional output distribution. In this paper, as in the case of missing data, we argue that exploiting correlations between multiple outputs can enable models to better address the bias introduced by censored data. To do so, we introduce a heteroscedastic multi-output Gaussian process model which combines the non-parametric flexibility of GPs with the ability to leverage information from correlated outputs under input-dependent noise conditions. To address the resulting inference intractability, we further devise a variational bound to the marginal log-likelihood suitable for stochastic optimization. We empirically evaluate our model against other generative models for censored data on both synthetic and real world tasks and further show how it can be generalized to deal with arbitrary likelihood functions. Results show how the added flexibility allows our model to better estimate the underlying non-censored (i.e. true) process under potentially complex censoring dynamics.

Topic: Gaussian Processes and Bayesian Inference
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Of Rape and Other Demons: The Impact of the Victim's Eye Size and Observer's Gender on the Attributions of Responsibility

This study examined the influence of the victim's eye size and observer's gender on the observers' perception of initial attraction and honesty of the victim, identification of the observer with a female target, and observers' attribution of victim's and perpetrator's responsibility for rape. A 3 (victim's eye size: small vs. normal vs. large) x 2 (observer's gender: female vs. male) experimental design was used. Participants (45 females and 45 males) observed one of three randomly assigned female faces (with eye size manipulation) and rated initial attraction, honesty, and identification. They were then asked to read a rape scenario (with a non-traditional woman) and to rate the victim's and offender's responsibility. The victim's eye size was shown a significant effect on all variables, except for perpetrator's responsibility. The female face with large eyes was perceived as more attractive and honest, elicited higher identification, and was attributed less responsibility. No significant effects were identified for observer's gender. Theoretical and practical implications were discussed.

Topic: Sexual Assault and Victimization Studies
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Thoracic paravertebral block versus transversus abdominis plane block in major gynecological surgery: a prospective, randomized, controlled, observer-blinded study

Andrey L Melnikov,1 Steinar Bjoergo,1 Ulf E Kongsgaard21Department of Anesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway; 2Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital and Medical Faculty, University of Oslo, Oslo, NorwayBackground and objectives: Patients undergoing abdominal surgery often receive an epidural infusion for postoperative analgesia. However, when epidural analgesia is contraindicated or unwanted, the administration of opioids is the usual means used to relieve pain. Various regional analgesia techniques used in conjunction with systemic analgesia have been reported to reduce the cumulative postoperative opioid consumption and opioid-induced side effects. The objective of this trial was to assess the effectiveness of transversus abdominis plane block and paravertebral block in women undergoing major gynecological surgery.Methods: We analyzed 58 patients scheduled for a midline vertical laparatomy due to gynecological cancer. They were all equipped with a patient-controlled postoperative analgesia pump that delivered ketobemidon. In addition, some patients were randomized to receive either a bilateral transversus abdominis plane block (n = 19) or a bilateral paravertebral block at the level of Th10 (n = 19). Both blocks were performed preoperatively as a single injection of bupivacaine.Results: Cumulative ketobemidon consumption, postoperative pain scores at rest and while coughing, and postoperative nausea and vomiting scores were assessed by a blinded observer at 2, 4, 6, 24, and 48 hours postoperatively. Both blocks were associated with significant reductions in opioid consumption and pain scores throughout the study period compared with the control patients. Postoperative nausea and vomiting scores were low in all groups, but during the early postoperative period more control group patients needed antiemetics.Conclusion: Both methods of inducing block can serve as effective analgesia adjuncts in women undergoing major gynecological surgery. Although thoracic paravertebral block appeared to be more effective than transversus abdomins block, the latter performed under ultrasound guidance seems to be a more controlled and safe alternative.Keywords: hysterectomy, transversus abdominis plane block, paravertebral block, postoperative pain

Topic: Anesthesia and Pain Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Hearing, listening and acting

We both did all right in physical education and sport while at school; if not the very
best, at least more likely to be picked than picked on. (Well, DC was a bit better than
that, as we suspect were the other authors in this collection.) Like the other contributors we might be seen as establishment insiders from the perspective of the young
people in these research projects, though not perhaps by the teachers/deliverers. It
is interesting that it is us – and ‘people like us’ – who take on the task of understanding and making sense of the experiences of young people who are perhaps not
having a similarly positive experience in physical education or sport.

Topic: Physical Education and Pedagogy
Subfield: Physical Therapy, Sports Therapy and Rehabilitation
Field: Health Professions
Domain: Health Sciences
Efficacy and safety of intrapatient dose escalation of sorafenib as first-line treatment for metastatic renal cell carcinoma (mRCC).

4609^ Background: Previous data of intrapatient dose-escalated sorafenib in mRCC suggest that doses up to 800 mg bid were manageable with enhanced activity in terms of PFS and responses compared to the standard dose of 400 mg bid. This phase II study was conducted to investigate these earlier findings. Methods: Main eligibility criteria were metastatic and/or unresectable clear cell RCC; at least one measurable lesion, ECOG PS 0/1, MSKCC score good or intermediate, no prior systemic anticancer therapy. Patients (pts) were to receive sorafenib 400 mg bid for 4 weeks, then 600 mg bid for 4 weeks and 800 mg bid from month 3 to 6+, with response evaluated at 6 months. The primary endpoint was response rate (best overall response) within the first 6 months of treatment (≥4 months of treatment at the highest tolerated dose for all pts). Results: Of the 83 enrolled pts (65% male) who received ≥ one dose of sorafenib (safety population); 16 withdrew due to grade 1/2 toxicities and 67 had ≥ one post-baseline assessment (ITT population). Dose escalation per protocol was tolerated by 18 pts; all achieved clinical benefit (9-PR; 9-SD). The other 49 pts had dose escalations and reductions as tolerated throughout the study. Results for the ITT population and subgroups taking 400, 600, or 800 mg bid for the longest time while on study are shown (Table). Median age in the 400, 600, and 800 mg bid groups was 64.5, 58.5, and 57 years, respectively; other baseline characteristics were comparable. No clinically relevant differences in the severity or frequency of side effects were seen across the 3 groups. Conclusions: In the majority of pts dose escalation per protocol was not feasible. Pts in whom the sorafenib dose could be escalated above 400 mg bid appeared to have greater clinical benefit. 400 mg bid (n=25) 600 mg bid (n=12) 800 mg bid (n=20) ITT population (n=67)* Partial response n (%) 1 (4) 2 (16.7) 7 (35) 12 (17.9) Stable disease n (%) 15 (60) 10 (83.3) 13 (65) 46 (68.7) Clinical benefit (PR+SD) n (%) 16 (64) 12 (100) 20 (100) 58 (86.6) Median PFS mo (95% CI) 3.7 (1.8-9.5) 7.4 (6.3-12) 8.5 (5.6-14.9) 7.4 (6.3-9.7) PFS rate at 12 months % 18.7 33.3 46.4 35.9 * The dose for the longest time on treatment was 200 mg/day for 3 pts and 400 mg/day for 7 pts.

Topic: Renal cell carcinoma treatment
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
PRODUCTION ENGINEERING OF METAL AND OTHER INERT PARTS FOR M30 ROCKET MOTOR FOR NIKE HERCULES MISSILE

It was recommended that the hydrostatic test time requirement be reduced to the time required for the hydrostatic pressure to stabilize at 900 psi. Of the blast tube insulating materials tested with a small scale rocket motor, an asbestosphenolic material was chosen for full scale testing. Various organic solvents including methylene chloride, and chloroform indicated there would be no difficulty in removing the polysulfide rubber liner; this would allow the reclaiming of metal parts after static firing, Susceptibility of metal motor parts to corrosion was determined and a number of refractory coatings were found protective. Tests were conducted on a loaded motor in low temperature environment to determine the rate of grain temperature change and the time that the rocket can be exposed to extreme temperatures without falling below the specified firing or storage temperature limits.

Topic: Rocket and propulsion systems research
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech

\nBackground: Detecting early signs of Alzheimerâs disease (AD) and mild cognitive impairment (MCI) during the pre-symptomatic phase is becoming increasingly important for cost-effective clinical trials and also for deriving maximum benefit from currently available treatment strategies. However, distinguishing early signs of MCI from normal cognitive aging is difficult. Biomarkers have been extensively examined as early indicators of the pathological process for AD, but assessing these biomarkers is expensive and challenging to apply widely among pre-symptomatic community dwelling older adults. Here we propose assessment of social markers, which could provide an alternative or complementary and ecologically valid strategy for identifying the pre-symptomatic phase leading to MCI and AD. Methods: The data came from a larger randomized controlled clinical trial (RCT), where we examined whether daily conversational interactions using remote video telecommunications software could improve cognitive functions of older adult participants. We assessed the proportion of words generated by participants out of total words produced by both participants and staff interviewers using transcribed conversations during the intervention trial as an indicator of how two people (participants and interviewers) interact with each other in one-on-one conversations. We examined whether the proportion differed between those with intact cognition and MCI, using first, generalized estimating equations with the proportion as outcome, and second, logistic regression models with cognitive status as outcome in order to estimate the area under ROC curve (ROC AUC). Results: Compared to those with normal cognitive function, MCI participants generated a greater proportion of words out of the total number of words during the timed conversation sessions (p=0.01). This difference remained after controlling for participant age, gender, interviewer and time of assessment (p=0.03). The logistic regression models showed the ROC AUC of identifying MCI (vs. normals) was 0.71 (95% Confidence Interval: 0.54 â 0.89) when average proportion of word counts spoken by subjects was included univariately into the model. Conclusion: An ecologically valid social marker such as the proportion of spoken words produced during spontaneous conversations may be sensitive to transitions from normal cognition to MCI.

Topic: Dementia and Cognitive Impairment Research
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Association of Non-Alcoholic Fatty Liver Disease with Metabolic Syndrome: A Single Center Study

Background: NAFLD is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver (&gt; 5% of hepatocytes histologically). Non-alcoholic fatty liver disease is increasingly being recognized as a major cause of liver-related morbidity and mortality among 15-40% of the general population. Aim of the study: To evaluate the clinical profile of patients with non-alcoholic fatty liver disease and its association with metabolic syndrome.Methods:The present cross-sectional, retro-spective study was conducted as outdoor patient basis in the Department of Medicine, Jashore medical college hospital &amp; a private diagnostic centre, Jashore.. A total of 74 cases were included for the study. All patients in the study underwent routine investigations including complete blood counts, blood sugar, liver function tests, HBsAg, anti-HCV, lipid profile andUSG of whole abdomen. The data was collected during OPD treatment and was recorded in predesigned and pretested proforma and analyzed.Results:Mean age of the patient was 53.70±7.22 years. On physical examination findings showed the mean BMI was 27.6±4.39 kg/m2, mean waist circumference was 74.22±7.44 cm. Mean diastolic blood pressure (mm Hg) was 92.87±6.25 and mean systolic blood pressure (mm Hg) 132.0±18.17. Maximum 52% patients had triglycerides &gt;150 mg/dl while low serum HDL level was seen in 37% patients and increased waist circumference was found in 32% patients. Altered ALT ≥41 IU was observed in 10 (62.50%) of Grade II of patients with NAFLD with metabolic syndrome. Central obesity was observed in 12 (75.00%) of Grade II patients with NAFLD with metabolic syndrome. While 14 (87.50%) Grade II of patients with NAFLD with metabolic syndrome showed impaired fasting glucose (&gt;110 mg/dl). Hypertriglyceridemia (&gt;150 mg/dl) in 12 (70.58%) seen in Grade I of patients with NAFLD without metabolic syndrome.Conclusion:Higher prevalence of all the components of metabolic syndrome in cases of NAFLD was observed. It can be concluded that symptoms and signs of NAFLD are non-specific and occur later in the course of the disease hence the physician should have a high index of suspicion in order to detect NAFLD early in the course of the disease.

Topic: Liver Disease Diagnosis and Treatment
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Layered languages of ludology : the core approach

1 1 Digital Games Interdisciplinary & Embedded 3 2 How to Tell a Game Playing Experience? 4 3 Adoptable Languages of Media Studies 11 4 Digital Games as Generators of Experience 13 5 Layered Languages – The Core Approach 14 5.1 Elementary Formal Language Levels . . . . . . . . . . . . . . . . 15 5.2 Elementary Mappings between Languages . . . . . . . . . . . . . 16 5.3 Higher Level Languages . . . . . . . . . . . . . . . . . . . . . . . 18 5.4 Relations in a Language Lattice . . . . . . . . . . . . . . . . . . . 18 5.5 Multi-Layer Language Expressions . . . . . . . . . . . . . . . . . 19 6 Summary and Conclusions 20

Topic: Multimedia Communication and Technology
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
The Effect of Work Environment, Work Discipline, and Work Motivation on Employee Performance in Manufacturing Company

The purpose of this study was to determine the significance of the effect of work environment, work discipline, and work motivation on employee performance. This research was conducted at the manufacturing company CV. Mertanadi. The theory used in this research, namely attribution theory, is put forward to study the process of how a person interprets an event, reason, or behavior. The number of samples in this study was 58 employees with the method of determining the sample, namely the saturated sampling technique. Data was collected by distributing questionnaires. The results showed that the work environment had a positive and significant effect on employee performance. Work discipline has a positive and significant effect on employee performance. Work motivation has a positive and significant effect on employee performance. The results of this study can be taken into consideration in making decisions and providing information to CV. Mertanadi to improve employee performance.

Topic: Employee Performance and Management
Subfield: Human Factors and Ergonomics
Field: Social Sciences
Domain: Social Sciences
Fractal Volatility Of Price Series

The problem of constructing an interval valuation of the volatility (root–mean–square deviation) of price time series is studied in this paper. Dependencies are given allowing determining the real, substantially different from the corresponding indicators under the normal law of their distribution, the volatility range based on the base time interval. The proposed methodology makes it possible to take into account the risks of investing in the real conditions of the functioning of the stock market. The study of the simplest algorithm for estimating the fractal dimensions of time series based on the calculation of the Hurst index is carried out. The method is based on a one-point approximation of the magnitude of the normalized span at the planning step by a linear function. The estimation of the spectrum of fractal dimensions based on the Hurst index is made, the analysis of which makes it possible to carry out a complex justification of the choice of a tool for investing. The practical approbation of the proposed methodology was carried out by examining the shares of issuers belonging to different echelons in terms of liquidity. The developed methods and algorithms are simple, unified and easily implemented, for example, in the MS Excel environment.

Topic: Complex Systems and Time Series Analysis
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Health technology assessment

Health technology assessment (HTA) provides information about the effectiveness, costs and broader impact of health technologies to those who plan, administer or receive care in the national health system. ''Technology'' includes all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. An HTA program addresses the questions to which patients and the national health systems need answers, by investigating four main factors: whether the technology (intervention) works, for whom and at what cost, and how it compares with alternatives. Health technology assessment is not simply another kind of research. It has a number of key features that are critical to its ongoing impact and distinguish it from research: it is policy oriented, it is interdisciplinary in its content and procedures, it summarizes information from databases/reviews and sometimes produces original data; moreover, those engaged in health technology assessment recognize the importance of disseminating and communicating the information acquired. Health technology assessment constitutes a bridge between the world of research and the world of decision-making, particularly policy-making, in health care.

Topic: Health Systems, Economic Evaluations, Quality of Life
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
A novel frequency discrimination method based on all phase FFT for anti-towed decoy

This paper proposes a novel frequency discrimination method and discusses its application on anti-towed decoy. Before describing the proposed method, the principle of all phase FFT is first introduced. Then, based on the property of phase invariant, a novel frequency discrimination method based on all phase FFT is presented. Furthermore, the performance is specifically analyzed via numerical experiments to demonstrate the advantages of all phase FFT. Compared with the conventional method, the proposed method has higher frequency resolution and is more suitable for distinguishing the target from the towed decoy. Simulation results verify the validity of the proposed method and show the good performance in anti-towed decoy jamming.

Topic: Wireless Signal Modulation Classification
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Simplified management of epistaxis

ABSTRACT Primary care, urgent care, and emergency department providers periodically treat epistaxis, either as recurrent nosebleed or an acute persistent episode. Silver nitrate application to the decongested and anesthetized nasal mucosa addresses the former in most cases. The plethora of commercial nasal packing devices testifies to the discomfort, technical difficulty, and frustration associated with traditional gauze-packing methods. Inflatable anterior nasal balloon packs reliably control most nosebleeds. Addition of a Foley catheter nasopharyngeal balloon pack manages most posterior epistaxis. Cautery and the two packing techniques mentioned above should treat most cases not requiring otolaryngology consultation or interventional radiology. Appropriate anesthetic and analgesics lessen the unpleasantness for both the patient and the provider. Topical moisturizing facilitates mucosal healing. Oxymetazoline 0.05% nasal spray provides the patient means to address rebleeding after discharge from treatment.

Topic: Vascular Anomalies and Treatments
Subfield: Genetics
Field: Medicine
Domain: Health Sciences