jimnoneill/paper-to-field-training huggingface dataset:
Digest: Experimental evidence of gene flow impacts on host adaptation to a parasite

Abstract Does gene flow disrupt or facilitate the evolution of parasite resistance in host populations? Lewis et al. use a host–parasite system consisting of Caenorhabditis elegans (host) and Serratia marcescens (parasite) to test the effect of gene flow on adaptation. They find that gene flow from parasite-resistant host populations with divergent genetic backgrounds promotes adaptation to parasites (increased resistance). Findings from this study can be used to address more complex cases of gene flow and can be applied in conservation efforts.

Topic: Evolution and Genetic Dynamics
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supporting data for "Nuclear quantum effects on zeolite proton hopping kinetics explored with machine learning potentials and path integral molecular dynamics"

Supporting data for "Nuclear quantum effects on zeolite proton hopping kinetics explored with machine learning potentials and path integral molecular dynamics" by M. Bocus, R. Goeminne, A. Lamaire, M. Cools-Ceuppens, T. Verstraelen and V. Van Speybroeck, <em>Nature Communications</em>, <strong>2023</strong>, 14, 1008. This dataset contains examples of input files, submission and analysis scripts to train and use a machine learning potential based on the Schnet architecture for the proton hopping reaction in the H-CHA zeolite. The complete DFT training set, obtained by unbiasing the forces printed by CP2K (with PLUMED coupling), is stored as extended xyz files in the folders DFT/A-B/training_data.xyz where A=1-3 and A&lt;B&lt;5. More details on the folder architecture can be found in the README.md file.

Topic: Advanced NMR Techniques and Applications
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Letting Go: Caring for the Dying and the Bereaved. Ian Ainsworth-Smith and Peter Speck

"Letting Go: Caring for the Dying and the Bereaved. Ian Ainsworth-Smith and Peter Speck." The Hospice Journal, 1(2), p. 121

Topic: Grief, Bereavement, and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Intermittent ovarian and thyroid failure and spontaneous twin pregnancy

Intermittent failure of two endocrine systems is unusual and presents diagnostic and management challenges. We report a case of a young woman with intermittent thyroid and ovarian failure who had spontaneous twin gestation four years after the diagnosis of premature ovarian failure was made. This case demonstrates coincidental biochemical and clinical thyroid and ovarian failure both of which spontaneously resolved with no treatment, although subsequently irreversible hypothyroidism ensued after the initial recovery. Elevated gonadotrophins with a menopausal pattern on more than one occasion, in an amenorrhoeic patient with menopausal symptoms, usually indicates permanent ovarian failure. This case demonstrates that this may not be true and while this is probably a rare occurrence, clinicians need to be aware of this possibility. It also re-emphasizes the need to consider the clinical picture when interpreting biochemical results.

Topic: Growth Hormone and Insulin-like Growth Factors
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Pupinidius gregorii Moellendorff 1901

3. Pupinidius gregorii (Moellendorff, 1901) Figs 1, 2 E–F, Buliminus (Pupinidius) gregorii Moellendorff, 1901: 345, pl. 14, figs 9, 10; Kobelt, 1902: 849, pl. 121, figs 9, 10. Pupinidius gregorii Yen, 1939: 84, pl. 7, fig. 52. Material examined. SMF-42003: Lectotype. Ho-dshi-kou b. Mu-Kua-tshi (unrecognized locality name. However this locality is close to some place between Wenxian of Gansu and Nanping of Sichuan), Szechwan, China. Slg. O.v.Moellendorff. SMF-42004: Paratypes. 2 fmss. Ho-dsi-kou b. Mu-kua-tshi, Szechwan, China. Distribution. Sichuan (type locality). Type locality. Ho-dshi-kou b. Mu-Kua-tshi (Sichuan). Diagnosis. Shell with one band; not striate. Aperture indistinctly with angular tubercle. Most swollen part at body whorl and/or penultimate whorl(s). With 7.735–7.750 whorls; height 19.9–21.3, diam. maj. 11.2–11.5. Re-description of shell. Elongate conic. Apex protruded. Most swollen part at body whorl and/or penultimate whorl(s). Dextral; more or less thin; solid; opaque; glossy; not speckled; not spirally grooved (except very weakly present near umbilical region, in type specimens); with 7.375–7.542–7.750 whorls. Whorls not shouldered; flattened. Growth lines usually not very clear. Embryonic shell smooth; polished; with 1.500–1.625–1.750 whorls. Postnuclear whorls smooth. Suture normal, without narrow defined zone on beneath whorl. Last whorl gradually ascending towards aperture; rounded at periphery; without smoothed spiral peripheral depression nor rugate region. Shell 19.9–20.8–21.3 high; 11.2–11.3– 11.5 in diam. maj. Height/width ratio 1.78–1.83–1.89. Aperture in a plane; completely attached to body whorl; ovate; not adnate (but insertions of peristome close to each other); somewhat oblique; not armed; indistinctly with angular tubercle; 8.6–9.5–10.6 high; 7.5–7.7–8.1 wide. Ratio of shell height to aperture height 1.98–2.20–2.32. Peristome reflexed with distinct cuff. Cuff made by reflexed peristome straight and not curved backward. Peristome expanded; sharp. Parietal callus distinct, or indistinct. Columellar margin reflexed. Columella vertical, or slightly oblique abaxially. Outer edge of columellar lip vertical. Umbilicus with very narrow opening. Apical whorls differently tinted. Shell multicoloured in chestnut with a broad white spiral band just above suture, umbilicus region chestnut.

Topic: Acne and Rosacea Treatments and Effects
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Hydrogeochemical study of Morang River draining Rajmahal basalt: Implication to mineral stabili

In this study geochemical investigation of Morang river, draining Rajmahal basalt was carried out to understand the basalt weathering and neoformations.This sessional river was sampled during post-monsoon period along with groundwater samples.Concentration of Ca 2+ and Mg 2+ is high in the upper reach of Morang River and lower reach is relatively high with Na + + K + cations.In all the samples, HCO 3 -is a dominant ion.River and groundwater samples shows Ca 2+ -Mg 2+ -HCO 3 hydrochemical facies.Dissolution of primary minerals and secondary minerals present in the voids of basalt are the major ion source to the river.Unusual high NO 3 -at few locations indicates the anthropogenic input.The pCO 2 is out of equilibrium with atmosphere (>10 -3.5 ) in water samples, indicating possible contribution from the soil CO 2 .All the water samples are either under-saturated or near saturation with respect to carbonates, except two river water.Mineral stability diagram suggests that water is in equilibrium with kaolinite, indicate the limited chemical weathering process in source area.Elemental ratio and Principle Component Analysis (PCA) suggests preferential weathering of pyroxene compared to plagioclase minerals; and pH controlled ionic concentration in the river and groundwater.

Topic: Mineral Processing and Grinding
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Faculty Opinions recommendation of A directional switch of integrin signalling and a new anti-thrombotic strategy.

Integrins have a critical role in thrombosis and haemostasis. Antagonists of the platelet integrin αIIbβ3 are potent anti-thrombotic drugs, but also have the life-threatening adverse effect of causing bleeding. It is therefore desirable to develop new antagonists that do not cause bleeding. Integrins transmit signals bidirectionally. Inside-out signalling activates integrins through a talin-dependent mechanism. Integrin ligation mediates thrombus formation and outside-in signalling, which requires Gα13 and greatly expands thrombi. Here we show that Gα13 and talin bind to mutually exclusive but distinct sites within the integrin β3 cytoplasmic domain in opposing waves. The first talin-binding wave mediates inside-out signalling and also ligand-induced integrin activation, but is not required for outside-in signalling. Integrin ligation induces transient talin dissociation and Gα13 binding to an EXE motif (in which X denotes any residue), which selectively mediates outside-in signalling and platelet spreading. The second talin-binding wave is associated with clot retraction. An EXE-motif-based inhibitor of Gα13-integrin interaction selectively abolishes outside-in signalling without affecting integrin ligation, and suppresses occlusive arterial thrombosis without affecting bleeding time. Thus, we have discovered a new mechanism for the directional switch of integrin signalling and, on the basis of this mechanism, designed a potent new anti-thrombotic drug that does not cause bleeding. PMID: 24162846 Funding information This work was supported by: NHLBI NIH HHS, United States Grant ID: HL080264 NHLBI NIH HHS, United States Grant ID: HL109439 NHLBI NIH HHS, United States Grant ID: T32 HL007829 NHLBI NIH HHS, United States Grant ID: R01 HL109439 NHLBI NIH HHS, United States Grant ID: R01 HL062350 NHLBI NIH HHS, United States Grant ID: R01 HL080264 NHLBI NIH HHS, United States Grant ID: HL062350 More Less keyboard_arrow_down

Topic: Cell Adhesion Molecules Research
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Conformation of magainin-2 and related peptides in aqueous solution and membrane environments probed by Fourier transform infrared spectroscopy

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of magainin-2 and related peptides in aqueous solution and membrane environments probed by Fourier transform infrared spectroscopyMichael Jackson, Henry H. Mantsch, and John H. SpencerCite this: Biochemistry 1992, 31, 32, 7289–7293Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/bi00147a012https://doi.org/10.1021/bi00147a012research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Antimicrobial Peptides and Activities
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Alteration of Folic Metabolism in Breast Cancer

Abstract : My postdoctoral research focuses on alteration of folate metabolism in breast cancer. The connection between folate metabolism and breast cancer has long been recognized. Paradoxically, we know relatively little about the basic science of folate metabolism in the context of breast cancer. We do not yet know whether folate metabolism is altered in breast cancer compared to normal mammary tissues, and whether this alteration can contribute to breast cancer pathogenesis. These are important questions to be addressed in my research. Our central hypothesis is that either direct mutations of folate metabolic enzymes, or altered signal transduction pathways in breast cancer (such as PI3K pathway hyperactivation), leads to altered folate metabolism, which in turn contributes to the uncontrolled cell growth seen in breast cancer. In this fellowship period (Year 1), I have been investing in developing key methodologies that are essential for studying alteration of folate metabolism in breast cancer. Notably, I have successfully developed and validated a robust HPLC method that permits quantitative assessment of intracellular folates and capturing of the dynamics of their interconversions upon various stimuli, thus paving the way for future endeavors in testing specific hypotheses. I have presented part of this project in the poster session of the 2014 FASEB Folic Acid, Vitamin B12, and One- Carbon Metabolism conference. We hope that by gaining basic knowledge of folate metabolism, we can build a firm foundation for rational design of therapeutics and for early detection and diagnosis of breast cancer.

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[HPLC characteristic fingerprints of Xinshenghua Keli].

Xinshenghua Keli is known as the "preferred prescription of postpartum", with large demand in the field of gynecologic medicine. However, the quality of the preparation is uneven in the market, so its clinical efficacy cannot be guaranteed. In order to improve and establish its quality control standard, high performance liquid chromatography (HPLC) was used to establish the fingerprint of Xinshenghua Keli. The detection was performed on Agilent 5 HC-C₁₈ (2) column(4.6 mm×250 mm, 5 microns) with methanol-0.1% formic acid solution as mobile phase for gradient elution, at a flow rate of 1 mL·min⁻¹ with column temperature of 25 °C. The injection volume was 10 μL and detection wavelength was set at the maximum value between 210.0 nm and 400.0 nm by Photo-Diode Array (PDA) detector. The fingerprint of 12 batches of high-quality Xinshenghua Keli was established and 43 common peaks were identified. The similarities of crowned products, 10 batches of ordinary ones made by Jiangsu Rongyu Pharmaceutical and 10 batches produced by different manufacturers were evaluated. The composition identification and source analysis for the common peaks were performed by comparing the retention time of herbal medicines and ultraviolet absorption spectrum, along with high performance liquid chromatography-mass spectrometry (HPLC-MS) technology. The established fingerprint of Xinshenghua Keli, has proven to have good precision, stability and repeatability through the methodology validation, so it can be used to comprehensively evaluate the quality of Xinshenghua Keli.

Topic: Medicinal Plant Pharmacodynamics Research
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
EXTERNAL ADJUSTMENT AND FLEXIBILITY OF THE EXCHANGE RATE REGIME: THE CASE OF TRANSITION COUNTRIES

Milton Friedman’s traditional claim is that flexible exchange rates facilitate external adjustment by means of their cor- rective movements before the balance of payments crisis occurs. In order to test this hypothesis, we employ the first order autoregression based on the panel data on exchange rate regime and external balance expressed as the share of balance of goods and services in GDP. The sample covers 16 Central and Eastern European (CEE) and 12 Common- wealth of Independent States (CIS) transition countries over the period 2000-2019. The results, which are based on the sample of all transition countries, failed to prove that more flexible exchange rate regimes facilitate external adjust- ment. When the analysis was performed on two groups of countries separately, the results showed that the deficit of balance of goods and services in CIS countries has a higher persistence compared to CEE countries. However, a more flexible exchange rate regime does not facilitate external ad- justment. On the other hand, in CEE countries, the relation- ship between exchange rate regime flexibility and the rate of balance of goods and services reversion exists, proving that Friedman’s hypothesis does hold.

Topic: Global Financial Crisis and Policies
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Innovation and output in OECD countries: implications upon emerging economies

The paper analyses the long run relationship between research and development expenditure and GDP in the OECD and emerging countries between 1991 and 2000 using panel cointegration methods. Our results suggest the long-run causality running from research and development investment towards GDP. Estimated elasticities show the increased importance of R&D investment, 1% increase in innovation investments generates on average a 0.58% increase of the output. In addition, we show that unit research and development investment increase generates higher returns in emerging than in developed economies.

Topic: Economic Growth and Productivity
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
The effect of Jupiter's satellites on the diffusion of protons

Proton diffusion data are calculated for the Jovian satellites Amalthea, Io, Europa, Ganymede, and Callisto, assuming an equatorial magnetic field at Jupiter's surface of 10 gauss. The cyclotron radius, bounce period, and drift period are calculated for 1 MeV protons. These characteristics and the proton energy at the satellite, mean life near the satellite before impact, and diffusion time are also calculated for 100 MeV protons which conserve their first adiabatic invariant. The longitudinal distance between successive bounces is of the order of a few satellite radii.

Topic: Astro and Planetary Science
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Immortalizing Central Nervous System Cells

Abstract This unit presents methods for isolating clonal, neural‐derived cell lines. One approach for isolating such neural cell lines involves a replication‐deficient retrovirus encoding a specific oncogene and a selectable marker which are used to infect dissociated CNS cells dissected at a developmental stage at which the cell population of interest has not undergone its terminal mitotic division. Also presented is a method for cloning by limiting dilution, which may be necessary to obtain a pure population of cells. Following growth under appropriate selection conditions, clones are isolated and tested for their ability to differentiate with the desired phenotypic properties. A method is also provided for coating tissue culture dishes, which is necessary for successful culture of CNS neurons.

Topic: Microtubule and mitosis dynamics
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Religious gift and environmental conservation: case study on the movement of GSR (Gerakan Seribu Rupiah) in Semarang municipality Central Java

Religious gift is a phenomenon that is commonly found in various religious communities. In Islam the terms like zakat, infaq, and shadakah referred to the kinds of religious gift. Indeed religious gift is one of the religious orders having the purposes to care for those less fortunate. Although the religious order is common but what is interesting is that the practices of religious gift varied between communities. Religious gift which is practiced in rural area will be differed to the one practiced in urban area. The variation is related to the type of community in which the practice implemented. There is an interesting phenomenon in a residential neighbourhood in Semarang Municipality, the capital of Central Java Province. In this neighbourhood there is a mosque-based movement naming Gerakan Seribu Rupiah (One thousand rupiahs movement). The movement was initiated and executed by women . It has many activities that are oriented to family empowerment. Some of the activities are delivering scholarship, loan for school tuition, loan for family support in economic empowerment, and food aid. What the most interesting of the program is related to a specific way for fund raising that involved all the residents in the residential housing. The program combined garbages from all the residents of the residential housing and support that the garbages given must be intended for religious gift. For the purpose of the description on this phenomenon, this article will show the Gerakan Seribu Rupiah (GSR) as a religious community movement having concern on natural conservation. The detail that will be described are the profile of GSR, religious value of the garbages based fund rising, and the effects of the program toward community in general. This kind of description will inspire another community movement which is based on religious gift.

Topic: Islamic Finance and Banking Studies
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
The uses of authenticity: “Speaking from experience” in a U.K. election broadcast

Abstract Authentic talk is treated as displaying features of spontaneous, unrehearsed discourse close in character to Goffman 's (1981) description of "fresh talk." In the broadcast context it has become associated with eye‐witness accounts and the rendering of firsthand experiences (see Scannell, 2001): the evident lack of a script provides a guarantee of authenticity. This article examines how features of authentic talk can be deployed in political broadcasting by analysing a Party Election broadcast from the U.K. Conservative Party where the message is conveyed as if through the experience of ordinary people.

Topic: Rhetoric and Communication Studies
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Data for Adaptive leadership overcomes persistence-responsivity tradeoff in flocking

Scripts to parse raw files of the simulation framework given by https://github.com/csviragh/robotsim, and data from which figures are generated for the paper titled 'Adaptive leadership overcomes persistence-responsivity tradeoff in flocking' by Boldizsar Balazs, Gabor Vasarhelyi and Tamas Vicsek, published in Journal of The Royal Society Interface in 2020.

Topic: Complex Network Analysis Techniques
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences