jimnoneill/paper-to-field-training huggingface dataset:
Incidence and risk of treatment-related mortality in patients with renal cell cancer (RCC) and non-RCC treated with mammalian target of rapamycin (mTOR) inhibitors.

347 Background: Inhibition of the mammalian target of rapamycin (mTOR) is an established therapeutic modality for multiple malignancies including renal cell carcinoma (RCC). Agents that target mTOR have been sporadically associated with an increased risk of potentially life-threatening adverse events. We performed an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in cancer patients treated with mTOR inhibitors, including RCC. Methods: MEDLINE/PubMed, conferences and clinicaltrials.gov databases were searched for articles reported from January 1966 to June 2012. Eligible studies were limited to trials of US Food and Drug Administration—approved mTOR inhibitors (everolimus and temsirolimus) that reported on patients with cancer, randomized design, and adequate safety profiles. Data extraction was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Statistical analyses were conducted to calculate the summary incidence, relative risk (RR), and 95% Confidence Intervals (CIs) by using random-effects or fixed-effects models on the basis of the heterogeneity of included studies. Results: In all 2,990 patients from 8 randomized controlled trials (RCTs) were included, 2033 from everolimus trials and 957 from temsirolimus trials. The incidence of FAEs related to mTOR inhibitors use was 3.4% (95% CI, 1.9-6.0) with a RR of 2.33 (95% CI, 1.32 to 4.10; P = .003) compared to control patients. On subgroup analysis, no difference in the rate of FAEs was found between everolimus and temsirolimus or between tumor types (RCC vs. non-RCC). No evidence of publication bias was observed. Conclusions: The use of mTOR inhibitors is associated with an increased risk of FAEs in RCC and non-RCC patients, compared with control patients.

Topic: Renal cell carcinoma treatment
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Genomic mapping of Tbx3 interactions in the heart

Het eiwit Tbx3, dat een cruciale rol speelt bij de aanleg van het hart, bindt zich bij mensen met een bepaalde genetische variatie minder goed aan het DNA. Dat kan de verklaring zijn voor de vatbaarheid van sommige mensen voor hartritmestoornissen. Transcriptiefactor Tbx3 is cruciaal voor het ontwikkelen van het centrale gedeelte van het hart en het geleidingssysteem. Onderzoek van Elaine Wong toont aan dat Tbx3 door binding genen reguleert die van belang zijn voor het normaal functioneren van het geleidingssysteem. Het blijkt dat sommige mensen met een bepaalde variatie in een van deze genen waaraan Tbx3 bindt, vatbaarder zijn voor hartritmestoornissen. Wong laat zien dat de oorzaak hiervan ligt bij de afgenomen binding van Tbx3 aan het stukje DNA van dit gen, waardoor de werking van het gen zou kunnen worden verstoord. De bevindingen kunnen een bijdrage leveren aan het ontwikkelen en verbeteren van medicijnen en andere therapieën tegen hartritmestoornissen.

Topic: Congenital heart defects research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A feature and conjunction visual search immersive virtual reality serious game for measuring spatial and distractor inhibition attention using response time and action kinematics

The results replicated previous findings, providing support for the use of immersive virtual reality technology for the simultaneous evaluation of spatial and distractor inhibition attention using complex 3D objects.

Topic: Spatial Neglect and Hemispheric Dysfunction
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Indica - 18. Buddhist Legends. Translated from the original Pāli text of the Dhammapada Commentary by Eugene Watson Burlingame. Harvard Oriental Series, vols. xxviii–xxx. 10¼ × 7⅛, 3 vols. Cambridge, Mass., 1921. - 19. Buddhist Parables. Translated from the original Pāli by Eugene Watson Burlingame. 9½ × 6½, xxix + 348 pp., 1 plate. New Haven, 1922. - 20. Anubuddha Buddhaghosa Thera's Paramatthajotika, or the commentary to the Khuddakapátha. … Edited by … Welipitiyé Déwánanda Théra … revised by … Mahagoda Siri Ñanissara Théra. 10 × 6½, i + vi + 176 pp., 1 plate. Colombo, 1922. - 21. Bhadantachariya Buddhadatta Maha Thera's Madhuratthavilásini, or the commentary to the Buddhawansa of the Khuddaka Nikáya. … Edited by … Yagirala Paññánanda Théra … revised by … Mahagoda Siri Ñanissara Théra. 10 × 6½, viii + 268 pp., 1 plate. Colombo, 1922.

Indica - 18. Buddhist Legends. Translated from the original Pāli text of the Dhammapada Commentary by Eugene Watson Burlingame. Harvard Oriental Series, vols. xxviii–xxx. 10¼ × 7⅛, 3 vols. Cambridge, Mass., 1921. - 19. Buddhist Parables. Translated from the original Pāli by Eugene Watson Burlingame. 9½ × 6½, xxix + 348 pp., 1 plate. New Haven, 1922. - 20. Anubuddha Buddhaghosa Thera's Paramatthajotika, or the commentary to the Khuddakapátha. … Edited by … Welipitiyé Déwánanda Théra … revised by … Mahagoda Siri Ñanissara Théra. 10 × 6½, i + vi + 176 pp., 1 plate. Colombo, 1922. - 21. Bhadantachariya Buddhadatta Maha Thera's Madhuratthavilásini, or the commentary to the Buddhawansa of the Khuddaka Nikáya. … Edited by … Yagirala Paññánanda Théra … revised by … Mahagoda Siri Ñanissara Théra. 10 × 6½, viii + 268 pp., 1 plate. Colombo, 1922. - Volume 55 Issue 3

Topic: Indian and Buddhist Studies
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Finding Relevant Points for Nearest-Neighbor Classification

Previous chapter Next chapter Full AccessProceedings Symposium on Simplicity in Algorithms (SOSA)Finding Relevant Points for Nearest-Neighbor ClassificationDavid EppsteinDavid Eppsteinpp.68 - 78Chapter DOI:https://doi.org/10.1137/1.9781611977066.6PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAboutAbstract In nearest-neighbor classification problems, a set of d-dimensional training points are given, each with a known classification, and are used to infer unknown classifications of other points by using the same classification as the nearest training point. A training point is relevant if its omission from the training set would change the outcome of some of these inferences. We provide a simple algorithm for thinning a training set down to its subset of relevant points, using as subroutines algorithms for finding the minimum spanning tree of a set of points and for finding the extreme points (convex hull vertices) of a set of points. The time bounds for our algorithm, in any constant dimension d ≥ 3, improve on a previous algorithm for the same problem by Clarkson (FOCS 1994). Previous chapter Next chapter RelatedDetails Published:2022eISBN:978-1-61197-706-6 https://doi.org/10.1137/1.9781611977066Book Series Name:ProceedingsBook Code:SOSA22Book Pages:v + 320

Topic: Advanced Image and Video Retrieval Techniques
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
The efficient market hypothesis and rational expectations macroeconomics. How did they meet and live (happily) ever after?

This paper benefitted, at an early stage, of the helpful and encouraging comments from Aurélien Goutsmedt, Mauro Boianovsky, and Ed Nelson. We are also grateful for the suggestions we have received in a number of seminars and conferences while presenting our work, notably the A. O. Hirschman seminar (Université Paris 1 Panthéon-Sorbonne), the 2019 History of Economics Society Annual Conference in New York, and the University of the West of England Economics Seminar. This version of our work has been greatly improved by the remarks of two anonymous referees; we thank them both for their careful reading and suggestions.

Topic: Economic Theory and Policy
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Supplementary Figure 1 from Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis

&lt;p&gt;Demethylation treatment in cGAS deficient ovarian cancer cell lines.&lt;/p&gt;

Topic: interferon and immune responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
EM algorithm estimation of a structural equation model for the longitudinal study of the quality of life

Health‐related quality of life (HRQoL) data are measured via patient questionnaires, completed by the patients themselves at different time points. We focused on oncology data gathered through the use of European Organization for Research and Treatment of Cancer questionnaires, which decompose HRQoL into several functional dimensions, several symptomatic dimensions, and the global health status (GHS). We aimed to perform a global analysis of HRQoL and reduce the number of analyses required by using a two‐step approach. First, a structural equation model (SEM) was used for each time point; in these models, the GHS is explained by two latent variables. Each latent variable is a factor that summarizes, respectively, the functional dimensions and the symptomatic dimensions to the global measurement. This is achieved through the maximization of the likelihood of each SEM using the EM algorithm, which has the advantage of giving an estimation of the subject‐specific factors and the influence of additional explanatory variables. Then, to consider the longitudinal aspect, the GHS variable and the two factors were concatenated for each patient visit at which the questionnaire was completed. The GHS and the two factors estimated in the first step can then be explained by additional explanatory variables using a linear mixed model.

Topic: Family Support in Illness
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Monozygotic twins discordant for trisomy 4: a case report and a literature review

Full trisomy 4 is estimated to occur in about 1–2% of spontaneous abortions with anomalous karyotype (Hassold et al. 1996). Cases involving trisomy 4 mosaicism have been rarely reported in the lite...

Topic: Assisted Reproductive Technology and Twin Pregnancy
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
The impact of surface integrity by hard turning versus grinding on rolling contact fatigue – Part I: Comparison of fatigue life and acoustic emission signals

ABSTRACT Hard turning and grinding are finishing processes for the manufacture of precision components, such as bearings, gears and cams. However, the effects of distinct surface integrity by hard turning versus grinding on rolling contact life are poorly understood. Four representative surface types were prepared: as‐turned, as‐ground, turned and polished and ground and polished. Surface integrity was characterized by surface topography, microstructure and micro/nanohardness. Fatigue tests were performed with an acoustic emission sensor and the signal processing software. The surface topographies show that skewness of the as‐ground surface is much more negative than the as‐tuned one while other surface parameters are equivalent. The turned surface has a thicker strain hardened zone and a thinner thermal affected zone than those of the ground one. The ground surface has higher micro‐ and nanohardness on surface and in the subsurface than the turned one. The amplitude of acoustic emission signal is the most stable and sensitive signal to fatigue failure. The turned surface may have a longer life (&gt; 84%) than the ground one with equivalent surface finish. The fatigue lives of the bearing assembly are nearly identical for the turned surface versus the polished surface and the turned polished surface versus the ground and polished surface. In addition, polishing may not necessarily improve fatigue life of the machined surface, but increase bearing assembly life as much as 40%.

Topic: Advanced machining processes and optimization
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
A Descriptive Study to Assess Knowledge and Attitude Regarding Ill-Effects of Substance Abuse among B.Sc. Nursing 1st Year &amp; GNM 1st Year Students of Selected Nursing College in Greater Noida (U.P.)

Substance abuse, also known as drug abuse, is<br> a patterned use of drug in which the user consumes the<br> substances in the amounts or which methods which are<br> harmful to themselves or others, and is form of<br> substance -related disorder.1 Aim: The study's aim was<br> to assess knowledge and attitude regarding ill-effects of<br> substance abuse among B.Sc. Nursing 1st year &amp; GNM<br> 1st year students of selected Nursing College.<br> Methodology: To assess knowledge and attitude<br> regarding ill-effects of substance abuse among B.Sc.<br> Nursing 1st year &amp; GNM 1st year students of selected<br> Nursing College, a descriptive design was utilised.The<br> target population for the study was B.Sc. Nursing 1st<br> year &amp; GNM 1st year students.The analysis of the data<br> was done using the study's aims and assumptions as the<br> basis for the sample size of 60. Statistical Package EZR -<br> Software version 2.4 was used to analyse the data.Conclusion:<br> As the findings of the present study revealed that<br> education regarding ill effects of substance abuse is<br> important for the nursing students as they are upcoming<br> nurses and they can impart the knowledge to their<br> adolescent patients on regular basis Nurses and nursing<br> students should conduct research and workshop on ill<br> effects of substance abuse.

Topic: Health and Well-being Studies
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Linking Language Skills and Social Competence in Children With Developmental Language Disorder: A Systematic Review and Meta-Analysis

Purpose: This systematic review and meta-analysis aimed to examine the association between language skills and social competence in children with developmental language disorder (DLD) and to assess the potential moderators of these associations. Method: The study was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified according to a search strategy carried out in PsycINFO, MEDLINE, Scopus, Linguistics and Language Behavior Abstracts, and ProQuest Dissertations and Theses Global databases. A total of 15,069 articles were independently double screened in the title and abstract phases, with 250 articles proceeding to a full-text review. Inclusion criteria comprised (a) a sample of children with DLD between the ages of 2 and 12 years, (b) a language measure, (c) a social competence measure, and (d) an appropriate statistic. Exclusion criteria were (a) intervention studies with no baseline data, (b) language measures based on preverbal abilities, (c) samples of children with DLD and other clinical conditions, and (d) studies without useable statistics. Data were extracted from 21 studies that met the eligibility criteria for the meta-analysis. Results: Pooled estimates across 21 studies ( M age = 7.52 years; 64% male) and 6,830 children indicated a significant association between language skills and social competence in children with DLD ( r = .18, 95% confidence interval [.12, .24], p &lt; .001), which was small in magnitude. The effect sizes were stronger in studies that assessed overall language skills than in those that specifically measured receptive or expressive language skills. Conclusions: Findings from this study support a subtle and reliable relationship between language and social competence in children with DLD. The implications and limitations of this study and its future directions are also discussed. Supplemental Material: https://doi.org/10.23641/asha.24514564

Topic: Language Development and Disorders
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Accuracy and stability improvement for meat species identification using multiplicative scatter correction and laser-induced breakdown spectroscopy

An efficient method has been developed to identify meat species by using laser-induced breakdown spectroscopy (LIBS). To improve the accuracy and stability of meat species identification, multiplicative scatter correction (MSC) was adopted to first pretreat the spectrum for correction of spectrum scatter. Then the corrected spectra were identified by using the K-nearest neighbor (KNN) model. The results showed that the identification rate improved from 94.17% to 100% and the prediction coefficient of variance (CV) decreased from 5.16% to 0.56%. This means that the accuracy and stability of meat species identification using MSC and LIBS simultaneously improved. In light of the findings, the proposed method can be a valuable tool for meat species identification using LIBS.

Topic: Laser-induced spectroscopy and plasma
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Tūhono : the United Collective : an exhibition report presented in partial fulfilment of the requirements for the degree of Masters of Māori Visual Arts, Massey University, Palmerston North, New Zealand

This exhibition report provides a detailed outline of the pathway undertaken to complete the requirements of a Masters of Māori Visual Arts Thesis and the presentation of works Tūhono in December 2017.&#13;\nTūhono explores the combination of tikanga Māori and customary techniques alongside modern and contemporary processes. The three pou whakairo were developed to align with the kaupapa Te Kore, Te Pō, and Te Ao Mārama. A range of tools and techniques, both traditional and contemporary were used to explore the medium.

Topic: Cultural Industries and Urban Development
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
The Role of Gut Microbiota in Different Types of Physical Activity and Their Intensity: Systematic Review and Meta-Analysis

Background. Intense exercise during training requires dietary modulation to support health and performance and differs in different types of activities. Diet, supplementation with prebiotics and probiotics, and, more recently, even physical activity can potentially improve health outcomes by modifying and protecting the gut microbiota. A systematic review and meta-analysis were conducted to investigate the modulation of gut microbiota in different types and intensities of physical activity and different lifestyles of athletes. Methods. The systematic review and meta-analysis were conducted according to the PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42024500826). Results. Out of 1318 studies, only 10 met the criteria for inclusion in the meta-analysis. The pilot study’s meta-regression analysis highlights the role of type and intensity of exercise in changing the B/B (Bacillota/Bacteroidota) ratio (p = 0.001). Conclusions. As gut training becomes more popular among athletes, it is necessary to map interactions between microbiota and different types of physical activity, personalized diets, physical activities, and ergogenic supplements to enhance performance and athletic wellness.

Topic: Gut microbiota and health
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Indirect Effects of COVID-19 on Maternal, Neonatal, Child, Sexual and Reproductive Health Services in Kampala, Uganda

Background: COVID-19 has impacted global maternal, neonatal and child health outcomes. We hypothesised that the early, strict lockdown which severely limited the movements of individuals in Uganda will have impacted access to services.<br><br>Methods: An observational study, using routinely collected health data from Electronic Medical Records was carried out, utilising data from July 2019 to December 2020 in Kawempe district, Kampala. The mean and 95% confidence intervals were calculated pre-COVID (July 2019 – February 2020) and post-COVID (March-December 2020). The means were compared using t-tests, and the monthly totals analysed as to whether they lay within or outside the normal range, compared to the previous 9 months. <br>Results: Antenatal attendances decreased 96% in April 2020 and remain below pre-COVID levels. We found a rise in adverse pregnancy outcomes for Caesarean sections (5%), haemorrhages related to pregnancy (51%), stillbirths (31%) and low-birth-weight (162%) and premature infant births (400%). We noted a drop in neonatal unit admissions, immunisation clinic attendance and delivery of all vaccinations except measles. There was an immediate drop in clinic attendance for prevention of mother to child transmission of HIV (now stabilised) and an increase of 348% in childhood malnutrition clinic attendance. Maternal and neonatal deaths, immediate post-natal care and contraceptive provision remained within normal limits. <br>Conclusion: The response to COVID-19 in Uganda has negatively impacted maternal, child and neonatal health, with the biggest and longest lasting impact seen in complications of pregnancy, stillbirths and low-birthweight infants likely due to delayed care-seeking behaviour. The decline in vaccination clinic attendance has implications for all vaccine-preventable diseases, with a cohort of infants currently unprotected. Further consideration of the impacts of restricting movement and limiting access to preventative services must be undertaken in responding to future pandemics if key maternal and child health services are to be maintained.<br>

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
JPET #145219 1 Selectivity of Agonists for the Active State of M1- M4 Muscarinic Receptor Subtypes

jpet.aspetjournals.org D ow nloaded from JPET #145219 2 Running title: Agonist activity at muscarinic receptor subtypes To whom correspondence should be addressed:

Topic: Receptor Mechanisms and Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides

Sulphonylureas stimulate insulin secretion from pancreatic β-cells primarily by closing ATP-sensitive K+ channels in the β-cell plasma membrane. The mechanism of channel inhibition by these drugs is unusually complex. As direct inhibitors of channel activity, sulphonylureas act only as partial antagonists at therapeutic concentrations. However, they also exert an additional indirect inhibitory effect via modulation of nucleotide-dependent channel gating. In this review, we summarize current knowledge and recent advances in our understanding of the molecular mechanism of action of these drugs.

Topic: Cardiac Ischemia and Reperfusion
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Electrodeposition of Bi‐Te Alloy Films

Electrochemical deposition of Bi‐Te alloy films from acidic solutions containing and has been investigated. The thickness, compound, and composition of the Bi‐Te alloy films have been examined using stylus‐type surface profiling techniques, x‐ray diffraction peak measurement, and inductively coupled plasma/Auger electron spectroscopy measurements. At potentials where limiting current was observed, the compositions of films were controlled by the mole ratio in the solutions and the relationship between the composition of electrodeposited films and the composition of electrolyte solutions was derived.

Topic: Electrochemical Analysis and Applications
Subfield: Electrochemistry
Field: Chemistry
Domain: Physical Sciences