jimnoneill/paper-to-field-training huggingface dataset:
678 Use of Mirabegron in anticholinergic-resistant functional bladder overactivity (OAB) – medium/long term outcomes

<h3>Objective</h3> Mirabegron (either alone or in combination with an anticholinergic) has been shown to be effective in adult patients with OAB but remains unlicensed in the Paediatric population. Our aim was to review the symptomatic outcome ≥24 months after starting Mirabegron in a Paediatric population with significant OAB who had failed urotherapy and anticholinergic medication with urodynamically proven detrusor overactivity. <h3>Methods</h3> Retrospective, single Centre review of lower urinary tract symptoms (LUTS) at start of therapy, 6, 12, 24 months and final follow up. <h3>Results</h3> 84 patients started Mirabegron (25–50mg daily), 56% female at a mean age 11 (range 5–17 years). Baseline LUTS: urinary urgency 81%, daytime wetting (DUI) 75%, (88% of these wet 7/7 days), enuresis (NE) 80% (91% of these wet 7/7 nights), combined day and night time wetting 58%. At 6 months: 71% remained on treatment. 4 patients dry off medication (further 4 had partial response and off medication) and 66% stated improvement. 50% on combination therapy (with anticholinergic). Of those on medication: urinary urgency 50%, DUI 47% (30% wet 7/7 days), NE 57% (33% wet 7/7 nights). At 12 months: 63% remained on treatment. Further 4 dry and off treatment. 70% on combination therapy. Of those on medication: urinary urgency 48%, DUI 43% (15% wet 7/7 days), NE 46% (26% wet 7/7 nights). At 24 months: 45% remained on treatment, further 10 dry off treatment. 79% on combination. Of those on treatment: urgency 29%, DUI 26% (18% wet 7/7 days), NE 26% (18% wet 7/7 nights). At last follow up (24–76 months): 21 patients remained on treatment. 71% on combination. Urinary urgency 19%, DUI 19% (14% severe 7/7) and NE 9% (9% wet 7/7 nights). <h3>Outcomes</h3> Improvement in incontinence over time is shown in figure 1. Overall, 73% good response to treatment with 54% dry (on or off medication) and a further 19% show partial response (50–90%improvement) Figure 2. The mean duration of Mirabegron therapy was 25.9 months. During follow-up 16 (19%) patients reported side effects with 4 stopping treatment. <h3>Conclusion</h3> Mirabegron alone, or in combination with an anticholinergic, offers a well-tolerated and effective treatment for children and young people suffering from frequent urinary incontinence caused by significant detrusor overactivity that has failed to respond to anticholinergics. Resolution of symptoms occurred in nearly half of patients by 24 months.

Topic: Urinary Bladder and Prostate Research
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Enoch H. Crowder: Soldier, Lawyer, and Statesman

Journal Article Enoch H. Crowder: Soldier, Lawyer, and Statesman. By David A. Lockmiller. (Columbia: University of Missouri Press, 1955. 286 pp. Illustrations, bibliography, and index. $5.00.) Get access Erna Risch Erna Risch Washington, D. C. Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 43, Issue 1, June 1956, Pages 146–147, https://doi.org/10.2307/1895317 Published: 01 June 1956

Topic: American Constitutional Law and Politics
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Peridaedala chlorissa

299. Peridaedala chlorissa (Meyrick, 1912) Acroclita chlorissa Meyrick, 1912; J. Bombay nat. Hist. Soc. 21: 859. TL: India, Assam, Khasi Hills [now in Meghalaya]. Distribution: India (Meghalaya); Sri Lanka. Illustrations: Adult and genitalia (Clarke 1958: 271).

Topic: Lepidoptera: Biology and Taxonomy
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Corrosion Behavior of Mild Steel in Sour Environments at Elevated Temperatures

Abstract The objective of this work was to determine the corrosion rate of mild steel and characterize the corrosion products in sour environments at temperatures ranging from 80°C to 200°C. First, a H2S-H2O water chemistry model was developed based on available literature for a closed system at high temperature. Then, H2S corrosion tests were conducted at 80°C, 120°C, 160°C and 200°C with an exposure time of 4 days. Linear polarization resistance (LPR) and weight loss (WL) methods were used to measure the corrosion rates. X-ray diffraction (XRD) and scanning electron microscopy with energy dispersive X-ray spectroscopy microanalysis (SEM/EDS) were employed to characterize the corrosion products and surface morphology. The results show that the initial corrosion rates increased with temperature then decreased as they achieved steady-state. The corrosion product was comprised of two distinct layers. The inner corrosion product was always an iron oxide layer (hypothesized to be Fe3O4), while mackinawite, troilite, pyrrhotite and pyrite were identified as the main components of the outer layer at 80°C, 120°C, 160°C and 200°C, respectively. Pourbaix diagrams generated based on the analysis of water chemistry corroborated the experimental characterization of the corrosion products.

Topic: Hydrogen embrittlement and corrosion behaviors in metals
Subfield: Metals and Alloys
Field: Materials Science
Domain: Physical Sciences
Artemisia argyi-Mediated Synthesis of Monodisperse Silver Nanoparticles as Components of Bioactive Nanofibrous Dressings with Dual Antibacterial and Regenerative Functions

The effective healing of chronic wounds requires balancing antimicrobial activity with tissue regeneration. In this study, we developed a novel, eco-friendly synthesis method using Artemisia argyi extract to produce silver nanoparticles (AgNPs), addressing toxicity concerns associated with conventional chemical synthesis methods. Through optimization of multiple synthesis parameters, monodisperse spherical AgNPs with an average diameter of 6.76 ± 0.27 nm were successfully obtained. Plant-derived compounds from Artemisia argyi extract acted as efficient mediators for both reduction and stabilization, yielding nanoparticles with high crystallinity. The synthesized AgNPs exhibited potent antibacterial activity against both Gram-negative and Gram-positive bacteria, with minimum inhibitory concentrations of 8 μg/mL against Escherichia coli and 32 μg/mL against Staphylococcus aureus, while maintaining high biocompatibility with L929 fibroblasts at concentrations ≤ 8 μg/mL. When integrated into polylactic acid/collagen type I (PLA/Col1) nanofibrous matrices, the optimized 0.03% AgNPs/PLA/Col1 dressing significantly accelerated wound healing in a diabetic rat model, achieving 94.62 ± 2.64% wound closure by day 14 compared to 65.81 ± 1.80% observed in untreated controls. Histological analyses revealed a dual-functional mechanism wherein controlled silver ion release provided sustained antibacterial protection, while concurrently promoting tissue regeneration characterized by enhanced collagen deposition, reduced inflammation, and increased neovascularization. This innovative approach effectively addresses critical challenges in diabetic wound care by providing simultaneous antimicrobial and regenerative functions within a single biomaterial platform.

Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Moduli of semistable sheaves as quiver moduli

In the 1980s Drézet and Le Potier realized moduli spaces of Gieseker-semistable sheaves on $\mathbb{P}^2$ as what are now called quiver moduli spaces. We discuss how this construction can be understood using t-structures and exceptional collections on derived categories, and how it can be extended to a similar result on $\mathbb{P}^1\times\mathbb{P}^1$.

Topic: Algebraic structures and combinatorial models
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Improved Multimodal Fusion for Small Datasets with Auxiliary Supervision

Prostate cancer is one of the leading causes of cancer-related death in men worldwide. Like many cancers, diagnosis involves expert integration of heterogeneous patient information such as imaging, clinical risk factors, and more. For this reason, there have been many recent efforts toward deep multimodal fusion of image and non-image data for clinical decision tasks. Many of these studies propose methods to fuse learned features from each patient modality, providing significant downstream improvements with techniques like cross-modal attention gating, Kronecker product fusion, orthogonality regularization, and more. While these enhanced fusion operations can improve upon feature concatenation, they often come with an extremely high learning capacity, meaning they are likely to overfit when applied even to small or low-dimensional datasets. Rather than designing a highly expressive fusion operation, we propose three simple methods for improved multimodal fusion with small datasets that aid optimization by generating auxiliary sources of supervision during training: extra supervision, clinical prediction, and dense fusion. We validate the proposed approaches on prostate cancer diagnosis from paired histopathology imaging and tabular clinical features. The proposed methods are straightforward to implement and can be applied to any classification task with paired image and non-image data.

Topic: AI in cancer detection
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Functions that Operate in the Fourier Algebra of a Compact Group

Only real-analytic functions operate in the Fourier algebra of any compact group that has an infinite abelian subgroup.This extends the theorems of Helson, Kahane, Katznelson, and Rudin [4] which apply to the algebra of absolutely convergent Fourier series on compact abelian groups.The Fourier algebra of a locally compact group has been studied by H. Mirkil [ó], W. F. Stinespring [9], R. A. Mayer [5], C. Herz [3], and most thoroughly by P. Eymard [l].We will state here the relevant definitions and facts, and prove that the restriction of the Fourier algebra to a closed subgroup is the Fourier algebra of the subgroup, and use this to lift up the theorem on operating functions.

Topic: Advanced Operator Algebra Research
Subfield: Mathematical Physics
Field: Mathematics
Domain: Physical Sciences
A Review Study for Grip Strengths of Hand

Many researches for grip strengths, using diverse ways such as subject, equipment, posture, method, has been conducted to investigate the differences of grip performance of dominant hand and non-dominant hand. It is hard to conclude, however, with one single or simple answer for this question based on researches due to various findings. Although 'the 10% rule' which is the dominant hand may produces a 10% greater grip strength than the non-dominant hand was often mentioned for this issue, there is still lack of supports for utilizing to general cases. This manuscript provides an overall review on the 53 research papers which were measured grip strengths of dominant as well as non-dominant hand in various conditions. According to this review study, many research findings reported that overall the grip strength differences between dominant and non-dominant hands were 6~10%, regardless of gender and age, followed by 0~5%, 11~15%, and over 16%. More detail information for grip strengths in both hands for gender and age groups were also presented in this study.

Topic: Muscle activation and electromyography studies
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
AN EMPIRICAL STUDY ON THE EFFECTS OF REGULATORY AND VOLUNTARY INITIATIVES TO CONTROL VOLATILE ORGANIC COMPOUNDS

VOCの削減を目的とした一連の政策には，「有害大気汚染物質の自主管理計画」と「自主的取り組みと法規制」の二つが存在する．本研究の目的は，これら二つの政策のどちらに削減の効果があったのかを検証することである．本研究では，分析の際に生じるセレクションバイアスをpropensity score matchingによりコントロールし，自主的取り組みや法規制がVOCの排出量および健康リスクに与える効果を計測することを試みた．そしてVOCの削減量/健康リスクについて，自主管理計画による場合と自主的取り組みと法規制の組み合わせによる場合の比較を行った結果，「有害大気汚染物質の自主管理計画」に参加した企業はVOCの健康リスク削減に成功したことが示された．

Topic: Regulation and Compliance Studies
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
A New fatty acid and some triterpenoids from propolis of Nkambe (North-West Region, Cameroon) and evaluation of the antiradical scavenging activity of their extracts

Abstract The aim of this work was to evaluate in vitro antiradical scavenging activity of propolis from Nkambe (North-West, Cameroon). The polyphenol content of the acetone extract was evaluated using the Folin-Ciocalteu reagent as 0.166±0.008 gGAE/100 gRM. Antiradical scavenging activity of hexane and acetone extracts was carried out on DPPH using ascorbic acid as standard. The results showed that the extracts possess antiradical activity with IC 50 of 141 μg/mL and 267 μg/mL for acetone and hexane extracts, respectively. The column chromatography separation on silica gel of the hexane fractionyielded compounds 1 to 3 . The structures of these compounds were elucidated by NMR and mass spectrometry data as Lupenone ( 1 ), a mixture of α and ß -Amyrin ( 2 ) and lastly Hexatriacontanoic acid ( 3 ) which was described for the first time from propolis.

Topic: Bee Products Chemical Analysis
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
A Study on of Make-up Design with the Application of Genre Deconstruction in Hybrids (Ver. 1)

Formatively and artistically aspect, a hybrid can be said to be a phenomenon in which two mutually different genres are combined. Make-up is thought to be very important to arrange the foundation available for predicting and pursuing a flow and direction of future hybrid make-up based on this, by analyzing a flow centering on hybrid trend, which was shown previously. In terms of objectives of this study, the first, aim is to suggest a model for researching make-up by grasping the developmental process and the characteristics of hybrid art through considering an art theory of hybridity, shown in make-up. The second, aim is to design make-up by analyzing trends in make-up style after deconstructing the hybrid genre. The modern make-up design through genre-deconstruction characteristics beyond diverse plurality and genre could be known to be highlighted as aesthetic characteristic by a slight attempt as communication of open space, which connects culture and genre, which had failed to be recognized and was neglected. Empirical research has, produced a work by systematically arranging make-up design. This study, identifies two kind of barrier demolition, such as the class deconstruction and the temporal, spatial disorder centering on genre deconstruction of hybrid. There are infinite possibilities in developing make-up design in line with modern sensation through aesthetic element and symbolic significance through genre deconstruction. It was the expression mode in future make-up, to providing basic data, and to strengthening competitive edge of culture and art.

Topic: Fashion and Cultural Textiles
Subfield: Museology
Field: Arts and Humanities
Domain: Social Sciences
About the strategy of development for professional and pedagogical competence of teachers in the field of special training of police officers

The article presents the results of a study carried out for the Public Service and Personnel Department of the Ministry of Internal Affairs of the Russian Federation. Based on the multidisciplinary and multisectoral approaches, the readiness of teachers of weapons and physical training for professional activities aimed at building competencies in the use of police force among employees is studied. Functions, role and potential of teachers formed the basis of strategic directions for the development of their professional and pedagogical competence in the field of special training. The professional and pedagogical competence of teachers in the field of special training of police officers is the competency associated with the ability to form the willingness of employees to use physical force and firearms. In this holistic personal quality, related components are distinguished: motivational value, cognitive, technological. In the empirical part of the work, a competency assessment scale is substantiated, the uniformity of the sample is evaluated, and the values of other statistical indicators that underlie the study are determined. The strategy for the development of professional and pedagogical competence of teachers in the field of special training for police officers is associated with the organization of professional activities, with the expansion of the educational potential of teachers. The strategy is aimed at organizing scientific and methodological activities, at developing new approaches to teaching, new technologies in the special training of police officers.

Topic: Psychology of Development and Education
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Transient Hyperglobulinemia and Plasmacytosis of Bone Marrow during an Acute Infection

Journal Article Transient Hyperglobulinemia and Plasmacytosis of Bone Marrow during an Acute Infection Get access Allan J. Goulding, M.D., Allan J. Goulding, M.D. From the Medical Service, Veterans Hospital, Bronx, New York Search for other works by this author on: Oxford Academic Google Scholar Manuel J. Rowen, M.D., Manuel J. Rowen, M.D. From the Medical Service, Veterans Hospital, Bronx, New York Search for other works by this author on: Oxford Academic Google Scholar Leo M. Meyer, M.D. Leo M. Meyer, M.D. From the Medical Service, Veterans Hospital, Bronx, New York Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 20, Issue 8, 1 August 1950, Pages 779–782, https://doi.org/10.1093/ajcp/20.8.779 Published: 01 August 1950 Article history Received: 21 January 1950 Published: 01 August 1950

Topic: Hematological disorders and diagnostics
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Anti-Inflammatory Effects of Isopropyl 3-(3, 4-Dihydroxyphenyl)-2-Hydroxypropanoate, a Novel Metabolite from Danshen, on Activated Microglia

Parallel abstracts Down-regulation of microglial activation represents a practical strategy for combating diverse brain disorders such as stroke and neurodegenerative diseases. In the present study, we showed evidence that isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP), a new bioactive metabolite of Danshen (Salvia miltiorrhiza Bunge), exerted an anti-inflammatory effect in lipopolysaccharide (LPS)-induced microglia. Our data showed that IDHP significantly reduced the production of nitric oxide (NO), tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in LPS-induced BV-2 cells and rat primary microglia in a dose-dependent manner. IDHP also suppressed mRNA expression of LPSinduced inducible nitric oxide synthase (iNOS), TNF-αand IL-1β. Moreover, IDHP significantly suppressed the production of reactive oxygen species (ROS), nuclear factor κB (NF-κB) translocation and DNA binding activity induced by LPS treatment in BV-2 cells. These findings indicated that IDHP might be of value in the treatment of various microglia-mediated neuroinflammatory diseases. Parallel keywords isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate ； microglia ； neuroprotection ； inflammation

Topic: Traditional Chinese Medicine Analysis
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation

Aims To clarify the association of p53 and CD34 expression with development of malignant solitary fibrous tumour we have studied 10 cases of solitary fibrous tumour arising in the pleura, retroperitoneum and pelvic cavity with clinicopathological features of malignancy. Methods and results Tumours were localized solid masses with or without necrosis in eight and they nearly totally occupied the pleural cavity in two. Basic histology of the tumours was the proliferation of spindle cells arranged in ‘patternless’ pattern or in interlacing bundles with nuclear atypia and mitotic activities of various degree. In two, high‐grade foci were present within low or intermediate‐grade tumours. Recurrent tumours also showed more atypical features than primary tumours in two. Immunohistochemical studies showed CD34 positivity in seven, but three of them showed marked diminution or complete loss of CD34 expression in high‐grade foci or a recurrent tumour. Three high‐grade cases showed totally negative staining for CD34. p53 was strongly expressed in cases with fatal outcome, clinical recurrence, nuclear atypia, high mitotic activity or local invasion, whereas almost negative in benign tumours. Conclusions Malignant solitary fibrous tumours may occur de novo or by transformation within benign or low‐grade tumours and may be associated with p53 mutation. Although CD34 is a useful marker in the diagnosis of solitary fibrous tumour, one should bear in mind that its expression can be lost in high‐grade tumours.

Topic: Soft tissue tumor case studies
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Motor innervation of large arteries: With particular reference to the lower limb

Journal Article Motor innervation of large arteries: With particular reference to the lower limb Get access J B Kinmonth, J B Kinmonth The Department of Surgery of St. Thomas's Hospital, LondonDepartment of Surgery, The Massachusetts General Hospital, Boston Search for other works by this author on: Oxford Academic Google Scholar F A Simeone F A Simeone The Department of Surgery of St. Thomas's Hospital, LondonDepartment of Surgery, The Massachusetts General Hospital, Boston Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 39, Issue 156, January 1952, Pages 333–335, https://doi.org/10.1002/bjs.18003915613 Published: 05 December 2005

Topic: Cardiovascular Issues in Pregnancy
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Delusional Bromidrosis in Psychotherapy – a Case Study

<b><i>Background: </i></b>Delusional disorders related to the skin, such as subjective bromidrosis, are clinically associated with a chronic course and doubtful prognosis. Case studies showing in detail the process of psychotherapy and its results are few. <b><i>Case Report: </i></b>A 32-year-old African graduate student suffered from the delusive idea that other people might be embarrassed by his 'malodor' (bromidrosis). He retired from social contact, stopped studying, and became increasingly depressed. He developed the conviction that he was afflicted with a life-threatening physical illness which had not yet been diagnosed. <b><i>Psychotherapy: </i></b>Transferred to our psychodermatological hospital unit, he entered a short-term course of psychodynamic treatment, which focussed on his projective defenses, directed against severe aggressive strivings resulting from a painful divorce. The patient gained insight and his complaints improved. <b><i>Follow-up: </i></b>After discharge, the patient's mental state improved clinically and psychometrically (SCL-90-R, ACS), compared with the initial scores. A follow-up 3 years later confirmed a gradual but decisive change in psychic functioning and a better social adjustment. <b><i> Conclusion: </i></b>The psychodynamic function of his symptomatology is discussed in summary. It can be concluded that insight-oriented, psychodynamic treatment may alleviate severe psychodermatological conditions.

Topic: Sympathectomy and Hyperhidrosis Treatments
Subfield: Physiology
Field: Medicine
Domain: Health Sciences