jimnoneill/paper-to-field-training huggingface dataset:
A journey's notes

Wilfred Bion first landed in our midst in 1967, invited by Frank Philips, one of the founders of the Sao Paulo Society, who had earlier trained in London and undergone analysis with both Klein and Bion. Our colleagues are unanimous in describing the profound impression this British psychoanalyst had upon our analytic milieu and the deep impact of his thought on the Brazilian Psychoanalytic Society of São Paulo. Almost immediately, his work came to predominate over the classical Kleinianism that had preceded it, offering a breath of innovation and stimulating ever deeper studies into the psyche and the analytic process. This situation lasted to the end of the 1980s, when its supremacy began to be questioned and was followed by an opening to other schools of thought and to a renewed interest in Freud's work. Bion, however, never ceased to be studied—and I believe it is no exaggeration to assert that to date his writings are one of the identifying marks of the São Paulo Society. The work of a great author instigates new intellectual adventures for those who investigate it—and this book bears witness to one of the products of this shared trajectory.

Topic: Psychotherapy Techniques and Applications
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Colorectal Cancer Screening and Surveillance

Colorectal cancer is the third most common cancer in men and women. The incidence and mortality rate of the disease have been declining over the past two decades because of early detection and treatment. Screening in persons at average risk should begin at 50 years of age; the U.S. Preventive Services Task Force recommends against routine screening after 75 years of age. Options for screening include high-sensitivity fecal occult blood testing annually, flexible sigmoidoscopy every five years with high-sensitivity fecal occult blood testing every three years, or colonoscopy every 10 years. In 2012, the U.S. Multi-Society Task Force on Colorectal Cancer updated its surveillance guidelines to promote the appropriate use of colonoscopy resources and reduce harms from delayed or unnecessary procedures; these guidelines provide recommendations for when to repeat colonoscopy based on findings. Adenomatous and serrated polyps have malignant potential and warrant early surveillance colonoscopy. Patients with one or two tubular adenomas that are smaller than 10 mm should have a repeat colonoscopy in five to 10 years. Repeat colonoscopy at five years is recommended for patients with nondysplastic serrated polyps that are smaller than 10 mm. Patients with three to 10 adenomas found during a single colonoscopy, an adenoma or serrated polyp that is 10 mm or larger, an adenoma with villous features or high-grade dysplasia, a sessile serrated polyp with cytologic dysplasia, or a traditional serrated adenoma are at increased risk of developing advanced neoplasia during surveillance and should have a repeat colonoscopy in three years. More than 10 synchronous adenomas warrant surveillance colonoscopy in less than three years. Colonoscopy may be repeated in 10 years if distal, small (less than 10 mm) hyperplastic polyps are the only finding.

Topic: Colorectal Cancer Screening and Detection
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Towards a ‘humanism of justice’ through restorative justice: a dialogue with history

The philosophical, legal, theological and anthropological origins of restorative justice and the programmes inspired by it are premised on a model of ‘doing justice’, which places the individual at its heart. This fact — which is revolutionary in that it marks a sea change from the criminal law perspective focusing solely on the perpetrator of the offence, and incorporates both the victim and the community into the handling of conflicts — has enabled restorative justice to be viewed as a kind of humanism of justice. The article explores the reasons for.

Topic: Criminal Justice and Corrections Analysis
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Copyright © 1997, American Society for Microbiology Characterization of Nicotinamide Mononucleotide

The enzyme nicotinamide mononucleotide (NMN) adenylyltransferase (EC 2.7.7.1) catalyzes the synthesis of NAD1 and nicotinic acid adenine dinucleotide. It has been purified to homogeneity from cellular extracts of the thermophilic archaeon Sulfolobus solfataricus. Through a database search, a highly significant match was found between its N-terminal sequence and a hypothetical protein coded by the thermophilic archaeon Methanococcus jannaschii MJ0541 open reading frame (GenBank accession no. U67503). The MJ0541 gene was isolated, cloned into a T7-based vector, and expressed in Escherichia coli cells, yielding a high level of thermophilic NMN adenylyltransferase activity. The expressed protein was purified to homogeneity by a single-step chromatographic procedure. Both the subunit molecular mass and the N-terminal sequence of the pure recombinant protein were as expected from the deduced amino acid sequence of the MJ0541 open reading frame-encoded protein. Molecular and kinetic properties of the enzymes from both archaea are reported and compared with those already known for the mesophilic eukaryotic NMN adenylyltransferase. NAD1 synthesis can be accomplished either via de novo pathways or through preformed pyridine ring salvage routes (13). All such pathways converge to the reaction nicotinamide mononucleotide (NMN) (or nicotinic acid mononucleotide) 1

Topic: Sirtuins and Resveratrol in Medicine
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Conversion of Nitroalkenes into β-(Trichloromethyl) Nitroalkanes

Abstract The cesium fluoride-catalyzed reaction of (trichloromethyl) - trimethylsilane with conjugated nitroalkenes affords β-(trichloromethyl)nitroalkanes.

Topic: Fluorine in Organic Chemistry
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
[Effects of kidney nourishing and spleen invigorating recipes on glucocorticoid receptors of pulmonary tissue and plasma corticosterone in asthmatic rats].

GQS, BSDCT and LJZT played an up-regulate role of GCR density and improvement of adrenocortical function in asthmatic rats in the management of asthma attacks.

Topic: Herbal Medicine Research Studies
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Uprooting the Pumpkin: Neo‐Colonial Therapeutic Interventions with Formerly Abducted Young People in northern Uganda

The impact of colonisation affects a number of formerly colonised societies. This paper addresses how therapeutic interventions in northern Uganda align with a colonial framework. It explores connections between the English invasion of northern Uganda in the mid‐1800s and therapeutic approaches to young people affected by armed conflict. Two case examples of treatment for young people at major reception centres are provided: (i) World Vision and (ii) Gulu Support the Children Organisation. Both draw on Western mental health interventions as the approach of choice rather than prioritising traditional Acholi values. This conceptual paper explores new directions for Western helping professional in the Global South.

Topic: Migration, Health and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Defense against the Present Accusers (24b3–28b2)

In defending himself against the charges of the first accusers, Socrates told us that he had refuted politicians, poets, and craftsmen but provided no examples of the characteristic errors he encountered. He now begins to correct this omission. In what Socrates describes as an attempt to defend himself against the present accusers (not their charges), he cross-examines and refutes the poet Meletus, who calls himself “good and patriotic,” or as we might say, noble and good (cf. 18a7–b1 and 24b3–4 with b4–6; on “attempt” see 20d2–4, 21c7–8).His effort to display Meletus' “pretense” to care sufficiently about, or to know, the matters concerning which he brings charges – and hence his unworthiness to bring them – shows us comically and obliquely some of what he found (23b6–7, 23d8–9, 24c4–9, 24d4, 24d7–9, 25c1–4, 26a8–b2).

Topic: Biblical Studies and Interpretation
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
[The intraoperative diagnosis of cardiomyocyte damage].

The morphology of myocardial biopsies taken in the course of the operative valve prosthesis is studied light and electron microscopically with the use of the fuchsinorrhagic index and tracer test. The dynamics and morphogenesis of cardiomyocyte injury depend upon their initial state. The myocardial changes characteristic of mitral valvular disease progress during the cardiac arrest. Besides that, observed the destabilization of membrane systems, tracer penetration of the injured cells and inner organelles, the fall of redox potential of mitochondria, the disturbance of the acidic hydrolases compartmentalization, the accumulation of multilamellar bodies indicating the membrane alteration. The combination of these changes determines the myocardial contractility in the period of rehabilitation and raises the risk during the prolonged operations. The suggested tests simultaneously give structural and metabolic estimation of the cardiomyocyte organelles in respect to the prognosis of irreversible injuries.

Topic: Cardiac Valve Diseases and Treatments
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Numerical simulation of material transport in a regional ground-water flow system

A numerical model of a regional ground-water flow system (not site specific) was coupled with a material transport model in order to study the influence of porosity and distribution coefficients in bedded media. The effects on model performance were discerned from long-term material transport simulations. Model performance was based on initial breakthrough time, average breakthrough time, and the standard deviation of the breakthrough curve at a discharge surface. Large differences in model performance occurred when the distribution coefficient was changed less than an order of magnitude, while small differences resulted from changing porosity several orders of magnitude.

Topic: Groundwater flow and contamination studies
Subfield: Environmental Engineering
Field: Environmental Science
Domain: Physical Sciences
An update on the incidence of type 1 diabetes during the <scp>COVID</scp> ‐19 pandemic years

The authors declare that they have no conflicts of interest. The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/dom.15182. Research data are not shared. Upon reasonable request to the corresponding author further analyses can be carried out. Data S1: Supporting information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Topic: COVID-19 and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Multiple Sclerosis Impact Scale (MSIS-29): relation to established measures of impairment and disability

Objective: To validate the newly developed Multiple Sclerosis Impact Scale (MSIS-29) in a large, well characterized, independent group of MS patients by investigating the relation between the MSIS-29 and the Guy’s Neurological Disability Scale (GNDS), the Expanded Disability Status Scale (EDSS) and the MS Functional Composite (MSFC). Methods: Two hundred MS patients were recruited at our outpatient department. At the same visit GNDS, EDSS, MSFC and MSIS-29 were assessed. Data obtained from GNDS, EDSS and MSFC assessment were compared to both physical and psychological impact scores of the MSIS-29. In addition the contribution of GNDS subcategories, EDSS functional systems and MSFC components to the physical and psychological impact scores of the MSIS-29 was studied. Results: Median scores were 37.5 for the physical and 22.2 for the psychological impact score of the MSIS-29, 13.0 for GNDS and 4.0 for EDSS. Mean MSFC was 0.07. The physical impact score showed good correlations with both GNDS (0.79) and EDSS (0.68) and a moderate correlation with the MSFC (- 0.53). The psychological impact score showed weak correlations with EDSS (0.22) and MSFC (-0.30) and a moderately strong correlation with the GNDS (0.58). In 50 (25%) patients, scores on physical and psychological impact scales diverted, i.e., a relative high score on one scale combined with a relative low score on the other scale. This was related to the clinical disease course. Conclusion: Our study supports the use of the MSIS-29 as a measure for the assessment of physical impact of MS on normal daily life. In addition, our data provides a deeper understanding of the factors that determine both physical and psychological disease impact. Discrepancies between the latter two aspects deserve further attention.

Topic: Multiple Sclerosis Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
U.S. nuclear weapons modernization and the impact on the nuclear nonproliferation regime

This chapter examines the tensions between United States (US) nuclear force modernization and the global nonproliferation regime, in the context of weakening US arms control/disarmament leadership and an increasingly challenging international security environment. It discusses the role that the US has played in driving the Nonproliferation of Nuclear Weapons (NPT) and regime through its leadership and political will, albeit this has wavered at various intervals since its inception in 1968. The chapter looks at US nuclear modernization and examine the tensions between US modernization programs and the divisions this is producing within the nuclear NPT. In 1975, the 91 states-parties to the NPT met for the treaty's first review conference and agreed to hold future conferences to review the implementation of the treaty every five years. Of course, the amplified declaratory statements and policy releases of the Trump administration appear to have only widened the gap between the United States modernization drive and meeting its obligations under the NPT.

Topic: Nuclear Issues and Defense
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
UV photodegradation of phenolic aldehydes present in industrial wastewaters. II. Simultaneous degradation of a mixture

Abstract The simultaneous photodegradation of four phenolic aldehydes by a polychromatic UV radiation was studied in a batch reactor. These phenolic substances, protocatechuic aldehyde (3,4‐dihydroxybenzaldehyde), p‐hydroxybenzaldehyde, syringaldehyde (4‐hydroxy‐3,5‐dimethoxybenzaldehyde) and vanillin aldehyde (4‐hydroxy‐3‐methoxy benzaldehyde), were selected because of they are major pollutants contained in wastewaters produced in some agro‐industrial plants. The degradation levels obtained are reported and the influences of the operating variables, temperature and pH, are established. Also, the quantum yields for the photoreaction of each individual aldehyde are evaluated by means of a competitive kinetic method, and correlated as a function of the temperature.

Topic: Water Quality Monitoring and Analysis
Subfield: Industrial and Manufacturing Engineering
Field: Environmental Science
Domain: Physical Sciences
Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

The blood-brain barrier (BBB) is a critical interface separating the central nervous system from the peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled a profound connection between the BBB and circadian rhythms, the endogenous oscillations synchronizing biological processes with the 24-hour light-dark cycle. This review explores the significance of circadian rhythms in the context of BBB functions, with an emphasis on substrate passage through the BBB. Our discussion includes efflux transporters and the molecular timing mechanisms that regulate their activities. A significant focus of this review is the potential implications of chronotherapy, leveraging our knowledge of circadian rhythms for improving drug delivery to the brain. Understanding the temporal changes in BBB can lead to optimized timing of drug administration, to enhance therapeutic efficacy for neurological disorders while reducing side effects. By elucidating the interplay between circadian rhythms and drug transport across the BBB, this review offers insights into innovative therapeutic interventions.

Topic: Circadian rhythm and melatonin
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
The Charged Classroom: Predicaments and Possibilities for Democratic Teaching

At a time when debate over school reform commands unprecedented attention, Judith L. Pace argues we must grapple with the underlying challenges of classroom teaching and, at the same time, strive to realize the ideals of democratic education. Building on three qualitative studies in grades four through twelve, The Charged Classroom examines the deeply embedded tensions, escalating pressures, and exciting possibilities of the contemporary American public school classroom. Through detailed descriptions and analyses of social studies and English language arts classrooms, Pace disentangles how teachers and students navigate three charged arenas: academic expectations, discussion of provocative topics, and curricular demands. In each domain, democratic learning opportunities, such as promotion of positive student identity, dialogue across differences, and exploration of conflict, are both opened up and closed down. A passionate and persuasive call for education reform, the book offers crucial insights about the realities of teaching and key recommendations for advancing democratic education in a multicultural society.

Topic: Educator Training and Historical Pedagogy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Dual-Modal Cellular Nanoparticles for Continuous Neurotoxin Detoxification

Neurotoxins are known for their extreme lethality. However, due to their enormous diversity, effective and broad-spectrum countermeasures are lacking. This study presents a dual-modal cellular nanoparticle (CNP) formulation engineered for continuous neurotoxin neutralization. The formulation involves encapsulating the metabolic enzyme <i>N</i>-sulfotransferase (SxtN) into metal-organic framework (MOF) nanoparticle cores and coating them with a natural neuronal membrane, termed "Neuron-MOF/SxtN-NPs". The resulting nanoparticles combine membrane-enabled broad-spectrum neurotoxin neutralization with enzyme payload-enabled continuous neurotoxin neutralization. The studies confirm the protection of the enzyme payload by the MOF core and validate the continuous neutralization of saxitoxin (STX). <i>In vivo</i> studies conducted using a mouse model of STX intoxication reveal markedly improved survival rates compared with control groups. Furthermore, acute toxicity assessments show no adverse effects associated with the administration of Neuron-MOF/SxtN-NPs in healthy mice. Overall, Neuron-MOF/SxtN-NPs represent a unique biomimetic nanomedicine platform poised to effectively neutralize neurotoxins, marking an important advancement in the field of countermeasure nanomedicine.

Topic: Nerve injury and regeneration
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Application of Machine Learning in Disease Prediction

Abstract: Healthcare is a sector that is always changing. Healthcare professionals may find it challenging to stay current with the constant development of new technologies and treatments. As a result, the purpose of this research paper is to try and implement machine learning features in a specific system for health facilities. Knowing if we are ill at an early stage rather than finding out later is crucial. The entire process of treatment can be made much more effective if the disease is predicted ahead using specific machine learning algorithms as opposed to directly treating the patient. In this work, disease is predicted based on symptoms using machine learning. Machine learning algorithms like Naive Bayes, Decision Tree, Random Forest, and KNN are used to forecast the disease on the provided dataset. As you can see, there are numerous potential applications of machine learning in clinical care in the areas of patient data improvement, diagnosis, and treatment, cost reduction, and improved patient safety.

Topic: Artificial Intelligence in Healthcare
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Mathematical modelling for degradation of water pollution by effective microorganism (EM) in river

Water quality has received considerable attention in allocation processes for maximizing the satisfaction of various sectors. However, pollutant impurities that impede adequate supply of water have a detrimental effect on the quality and harmful for living organisms. For the reduction of water river pollution level, various chemical and biological treatments are available but most of them are costly and non-eco-friendly. However, effective microorganism (EM) technology can save the cost and safely able to purify and clean rivers pollution. Therefore, mathematical model for river pollution has been developed and the effect of EM on the degradation of pollutant in river is studied. The model equations consist of a system of three one dimensional non-linear partial differential equations (PDE). A mathematical model has been simulated to describe degradation of pollutant in river. By using MAPLE software, explicit finite difference method is used to solve the system of non-linear PDE. To see the effect of addition of EM on river pollution, the three cases need to be considered where three different initial bacterial concentrations (25 50 ) are used. Based on the results, a low concentration of pollutant can be achieved in shorter distance and time when higher bacterial concentrations applied.

Topic: Agriculture, Plant Science, Crop Management
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
2. Some Factors Affecting Modern Contract Law

This chapter discusses factors affecting contract law which will be met in the rest of this book. It can usefully be read both at the beginning and the end of the book. These include continental influence in the nineteenth century; the influence of economic theory; inequality of bargaining power; the use of standard form contracts; consumer protection; the relationship between standard form contracts, inequality of bargaining power, and consumer protection; contractual behaviour; the interrelationship of contract and tort; good faith in contract law; the globalization of contract law; and the Human Rights Act 1998.

Topic: Legal principles and applications
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Common coupled fixed point results for probabilistic φ -contractions in Menger PGM-spaces

We consider several hybrid probabilistic contractions with a gauge function ϕ.Without any continuity or monotonicity conditions for ϕ, we obtain some new common coupled fixed point theorems in M enger P GM -spaces.Finally, an example is given to illustrate our main results.

Topic: Fixed Point Theorems Analysis
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences