jimnoneill/paper-to-field-training huggingface dataset:
Policy Gradient Reinforcement Learning for Uncertain Polytopic LPV Systems based on MHE-MPC

In this paper, we propose a learning-based Model Predictive Control (MPC) approach for the polytopic Linear Parameter-Varying (LPV) systems with inexact scheduling parameters (as exogenous signals with inexact bounds), where the Linear Time Invariant (LTI) models (vertices) captured by combinations of the scheduling parameters becomes wrong. We first propose to adopt a Moving Horizon Estimation (MHE) scheme to simultaneously estimate the convex combination vector and unmeasured states based on the observations and model matching error. To tackle the wrong LTI models used in both the MPC and MHE schemes, we then adopt a Policy Gradient (PG) Reinforcement Learning (RL) to learn both the estimator (MHE) and controller (MPC) so that the best closed-loop performance is achieved. The effectiveness of the proposed RL-based MHE/MPC design is demonstrated using an illustrative example.

Topic: Advanced Control Systems Optimization
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
LHD LHDGAUSS_RAY_MWRM3 #161582.1 (analyzed)

Ray trajectories for microwave reflectometry (mwrm) at set3 point obtained using ray-tracing code LHDGauss.

Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Percutaneous Hallux Valgus Surgery Without Distal Metatarsal Articular Angle Correction

Background. Many factors are considered predictors of recurrence after hallux valgus (HV) surgery, including preoperative distal metatarsal articular angle (DMAA). The restoration of the bone and joint alignment would be more important than realigning the cartilaginous surface of the metatarsal head. Therefore, is DMAA correction essential for a good clinical and radiological results after HV surgery? This study aims to illustrate the results of percutaneous forefoot surgery (PFS) for correction of HV deformity without DMAA correction. Material and Methods. A prospective single-center study of 74 patients (89 feet), with mild-to-moderate hallux valgus deformity, who underwent PFS. The mean latest follow-up was 57.3 months. Results. Preoperative median visual analog scale was 7 points and AOFAS scores were 52 points. At the mean latest follow up both scores improved to 0 points and 90 points, respectively. Median HV angle and intermetatarsal angle changed from 30° and 12° preoperatively, to 21° and 11° at mean latest follow-up. Overall, 80% of the patients were satisfied or very satisfied. Recurrence of medial first metatarsal head pain occurred in 12 cases (13.5%). Conclusions. PFS, without DMAA correction, is a valid procedure for surgical correction in patients with HV, despite the slightly worse radiographic results in our study. Levels of Evidence: Level II: Prospective study

Topic: Foot and Ankle Surgery
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Anomalous Origin of a Branch Pulmonary Artery From the Ascending Aorta (Hemitruncus)

Anomalous origin of a branch pulmonary artery from the ascending aorta (AOPAA) has been reported to exist with tetralogy of Fallot (TOF), interrupted aortic arch, aortopulmonary window, isthmic hypoplasia, and ventricular septal defects. Right pulmonary artery origin from the ascending aorta (AORPA) occurs from abnormal migration of the right sixth aortic arch. The right pulmonary artery (RPA) usually arises near the sinotubular junction from the right or posterior aspect of the ascending aorta. Anomalous origin of the left pulmonary artery (AOLPA) occurs when the left pulmonary artery (LPA) arises from the persistent aortic sac as a result of absence of the left sixth arch with persistence of the left fifth arch. Advanced medical imaging with computed tomography angiography (CTA) or magnetic resonance imaging (MRI) is quite useful for operative planning. The repair is performed via a median sternotomy approach with the use of hypothermic cardiopulmonary bypass.

Topic: Congenital Heart Disease Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Spontaneous and induced cerebral plasticity during autobiographical memory and episodic future thinking performance in relapsing-remitting multiple sclerosis patients

Based on a double approach in clinical neuropsychology and neuroimaging, the aim of thepresent thesis was twofold: (i) to study relapsing-remitting multiple sclerosis (RR-MS)patients presenting with autobiographical memory (AM) and episodic future thinking (EFT) impairment, and (ii) to improve AM and EFT functioning in the same patients.Thus, we showed a deficit in both AM and EFT in RR-MS patients, which was expressed by spontaneous brain activity changes in key brain regions of the AM and EFT networks,relatively to healthy controls. Then, we documented that the use of a mental visual imagery (MVI)-based facilitation programme led to AM and EFT improvement, which was notattributable to nursing or learning effects. This clinical benefit was accompanied with anincreased reliance on distinct key brain regions of the core AM and EFT network.Overall, we documented the effectiveness of cognitive facilitation for AM and EFT, and the occurrence of spontaneous and induced brain plasticity changes during AM and EFT performance in RR-MS patients, which were sustained by both common and distinct cerebral mechanisms.

Topic: Multiple Sclerosis Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
[Value of deep small-bowel endoscopy in the diagnosis of Crohn's disease].

DSBE is a valuable modality for detecting CD lesions in the jejunum and ileum and for evaluating lesion involvement and severity. The combination with a comprehensive analysis of routine imaging findings, gastro endoscopy, and clinical data can further enhance the diagnostic efficiency of DSBE.

Topic: Gastrointestinal Bleeding Diagnosis and Treatment
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
AI Ethics in Predictive Policing: From Models of Threat to an Ethics of Care

The adoption of data-driven organizational management - which includes big data, machine learning, and artificial intelligence (AI) techniques - is growing rapidly across all sectors of the knowledge economy. There is little doubt that the collection, dissemination, analysis, and use of data in government policy formation, strategic planning, decision execution, and the daily performance of duties can improve the functioning of government and the performance of public services. This is as true for law enforcement as any other government service.

Topic: Regulation and Compliance Studies
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
A Hierarchical Game Approach to WSP Selection and Bandwidth Allocation in Multi-Tier HCNs

In this work, the inter-linked problems of bandwidth allocation for wireless service providers (WSPs) and WSP selection for users in heterogeneous cellular networks (HCNs) are addressed by employing a multi-hierarchical game framework. Wherein, while the interaction between users are modelled using evolutionary game theory, the interactions between competing WSP's are modelled as a non-cooperative spectrum bandwidth allocation game (N-BAG). Moreover, the interaction between the WSPs and users is modelled as a multi- leader multi-follower Stackelberg game. After that, for the formulated evolutionary game, the existence and uniqueness of the evolutionary equilibrium (EE) was investigated. Conditioned on the obtained EE, the existence of a Nash equilibrium (NE) for the proposed N-BAG has been further proven and an offline algorithm to achieve the equilibrium state was proposed. Finally, simulation results verify the validity of our analysis and demonstrate that a unique NE would be achieved by the HCNs adopting the developed algorithm.

Topic: Advanced MIMO Systems Optimization
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Retinal Changes in Astrocytes and Müller Glia in a Mouse Model of Laser-Induced Glaucoma: A Time-Course Study

Macroglia (astrocytes and Müller glia) may play an important role in the pathogenesis of glaucoma. In a glaucoma mouse model, we studied the effects of unilateral laser-induced ocular hypertension (OHT) on macroglia in OHT and contralateral eyes at different time points after laser treatment (1, 3, 5, 8 and 15 days) using anti-GFAP and anti-MHC-II, analyzing the morphological changes, GFAP-labelled retinal area (GFAP-PA), and GFAP and MHC-II immunoreactivity intensities ((GFAP-IRI and MHC-II-IRI)). In OHT and contralateral eyes, with respect to naïve eyes, at all the time points, we found the following: (i) astrocytes with thicker somas and more secondary processes, mainly in the intermediate (IR) and peripheral retina (PR); (ii) astrocytes with low GFAP-IRI and only primary processes near the optic disc (OD); (iii) an increase in total GFAP-RA, which was higher at 3 and 5 days, except for at 15 days; (iv) an increase in GFAP-IRI in the IR and especially in the PR; (v) a decrease in GFAP-IRI near the OD, especially at 1 and 5 days; (vi) a significant increase in MHC-II-IRI, which was higher in the IR and PR; and (vii) the Müller glia were GFAP+ and MHC-II+. In conclusion, in this model of glaucoma, there is a bilateral macroglial activation maintained over time involved in the inflammatory glaucoma process.

Topic: Glaucoma and retinal disorders
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
On the Effective Development of Pharmaceutical Service of the Hospital

Objective: To investigate the quality and connotation of pharmaceutical service of the hospital and develop it significantly. Methods: The subjects correlated with pharmaceutical service were respectively analysed. Results: Nowadays in our country,whether the pharmaceutical service of the hospital can be effectively developed or not has to depend on hospital controllers and its system but not simply clinical pharmacists. Conclusion: The supporting of more subjects is the basic characteristic of pharmaceutical service of the hospital, which need to greatly co-operate with hospital controllers, staff and pharmacists for the effective development of pharmaceutical service of the hospital.

Topic: Pharmacy and Medical Practices
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Social Modeling for Requirements Engineering

A novel perspective on requirements engineering, founded on social concepts and strategic analysis of relationships among social actors. Much of the difficulty in creating information technology systems that truly meet people's needs lies in the problem of pinning down system requirements. This book offers a new approach to the requirements challenge, based on modeling and analyzing the relationships among stakeholders. Although the importance of the system-environment relationship has long been recognized in the requirements engineering field, most requirements modeling techniques express the relationship in mechanistic and behavioral terms. This book describes a modeling approach (called the i* framework) that conceives of software-based information systems as being situated in environments in which social actors relate to each other in terms of goals to be achieved, tasks to be performed, and resources to be furnished. Social perspectives on computing have provided much insight for many years. The i* framework aims to offer a modeling approach to the relationships embedded in computer systems that is part of an engineering method that offers systematic techniques and tools providing smooth linkages to the rest of the system development process, including system design and implementation. The book includes Eric Yu's original proposal for the i* framework as well as research that applies, adapts, extends, or evaluates the social modeling concepts and approach.

Topic: Software Engineering Techniques and Practices
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Genotype, extrapyramidal features, and severity of variant ataxia-telangiectasia.

OBJECTIVE: Variant ataxia-telangiectasia is caused by mutations that allow some retained ataxia telangiectasia-mutated (ATM) kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant ataxia-telangiectasia and explore genotype-phenotype correlations. METHODS: Cross-sectional data were collected retrospectively. Patients were classified as variant ataxia-telangiectasia based on retained ATM kinase activity. RESULTS: The study includes 57 individuals. Mean age at assessment was 37.5 years. Most had their first symptoms by age 10 (81%). There was a diagnostic delay of more than 10 years in 68% and more than 20 years in one third of probands. Disease severity was mild in one third of patients, and 43% were still ambulant 20 years after disease onset. Only one third had predominant ataxia, and 18% had a pure extrapyramidal presentation. Individuals with extrapyramidal presentations had milder neurological disease severity. There were no significant respiratory or immunological complications, but 25% of individuals had a history of malignancy. Missense mutations were associated with milder neurological disease severity, but with a higher risk of malignancy, compared to leaky splice site mutations. INTERPRETATION: Individuals with variant ataxia-telangiectasia require malignancy surveillance and tailored management. However, our data suggest the condition may sometimes be mis- or underdiagnosed because of atypical features, including exclusive extrapyramidal symptoms, normal eye movements, and normal alpha-fetoprotein levels in some individuals. Missense mutations are associated with milder neurological presentations, but a particularly high malignancy risk, and it is important for clinicians to be aware of these phenotypes. ANN NEUROL 2019;85:170-180.

Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Safety Reviews of Existing Roads: Quantitative Safety Assessment Methodology

Safety reviews of existing roads are becoming an accepted practice in many agencies around the world. These reviews can be highly cost-effective, but the subjective nature of the process can give rise to inconsistencies that limit their effectiveness. To address this issue, a technique to support safety reviews to quantify the safety gains that could be achieved by addressing the problems identified in the review process is presented. The approach is based on known accident relationships. A systematic process to determine which road features should be investigated and how each feature should be evaluated during the review is described. The procedure addresses rural two-lane highways at nonintersections. From the process, a potential for a safety improvement index (PFI) was calculated. Validation of the procedure was carried out by a comparison of the PFI values with the expected collision frequency. PFI was assessed in 406 km of rural two-lane rolling highways in Italy. Collision frequency was determined by application of a collision prediction model, calibrated in the study network, and was refined by application of the empirical Bayes (EB) technique. Correlation between EB safety estimates and PFI values is highly significant, with 93% of the variation in the estimated number of accidents explained by the PFI value. Because of the validation and quantitative nature of the PFI, the procedure can be used to support safety reviews and decision making.

Topic: Traffic and Road Safety
Subfield: Safety, Risk, Reliability and Quality
Field: Engineering
Domain: Physical Sciences
Supplementary Table S6 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1

&lt;p&gt;Two Spreadsheets of RNAseq data for Supplementary Figure 5A and 5B.&lt;/p&gt;

Topic: Chromatin Remodeling and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Association Between Income and Life Expectancy in the United States, 2001-2014

In the United States between 2001 and 2014, higher income was associated with greater longevity, and differences in life expectancy across income groups increased over time. However, the association between life expectancy and income varied substantially across areas; differences in longevity across income groups decreased in some areas and increased in others. The differences in life expectancy were correlated with health behaviors and local area characteristics.

Topic: Global Health Care Issues
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Information security of educational environments of school

\nThe information as an important ecological factor, which defines the security, development and health of children is considered. The article raises the problem of distortion of the information environment of childhood in the post-industrial era. The aim is to ensure information security educational environment for all participants in the educational process. It is proved that the hygienic approach to solving problems is insufficient. Adaptive-developing strategy for information security of the educational environments for children was theoretically justified and proved by the practical results of medical, physiological and neuropsychological research. It provides the school work on the compensation of violations of the information environment of childhood; development resources of students’ resistance to information stress; expanding the sphere of their adaptation to the information load (adaptive norm); the principles and structure of management of educational process on the basis of system-wide control of complex, self-regulating systems.\n

Topic: Technology and Human Factors in Education and Health
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
How Health Information Technology Is Failing to Achieve Its Full Potential

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal

Topic: Electronic Health Records Systems
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Expression of HPV16/18 in Esophageal Squamous Carcinoma in Taixing Area

Objective To explore the expression of human papilloma virus 16/18(HPV16/18) in esophageal squamous carcinoma.Method We applied double-exploring probe to detect HPV16/18 in 72 cases of esophageal squamous carcinoma,18 cases of normal esophageal normal mucosa,12 cases of low-grade intraepithelial neoplasia and 18 cases of high-grade intraepithelial neoplasia and studied its relationship with esophageal squamous carcinoma.Results The positive rate of HPV16/18 in esophageal squamous carcinoma was 55.67%(40/72).The positive rate of HPV in normal esophageal epithelium,high-grade intraepithelia neoplasia and low-grade intraepithelial neoplasia was remarkably lower than that of esophgeal carcinoma and it had statistic significance(P 0.05).Conclusion HPV16/18 had no correlation with the clinical staging,pathological grading,gross morphology,lymph node metastasis,sex,age and the invasive depth of esophageal squamous carcinoma,but had some correlation with maglignant transformation of esophageal squamous epithelium and can provide proof for preventive treatment of esophageal squamous carcinoma.

Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
D^0-$\bar D^0$ Mixing and CP Violation from FOCUS Experiment

Measurement results on $D^0$-$\bar D^0$ mixing and CP violation are presented. FOCUS, a fixed target experiment at Fermilab, collected a high statistics photo-produced charm sample collected during the 96-97 run. We reconstructed more than 1 million charmed particles and compared the lifetimes of two $D^0$ meson decays to $K^-π^+$ and $K^-K^+$. The mixing parameter, $y_{\rm cp}$, we obtained is $(3.42\pm 1.39\pm 0.74)%$. We also searched CP asymmetries in $D^+\to K^-K^+π^+$, $D^0\to K^-K^+$ and $D^0\to π^-π^+$ decay modes. We did not see any evidence of CP violation by comparing the decay rates for particle and antiparticle.

Topic: Particle physics theoretical and experimental studies
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities

Abstract Although higher-order cognitive and lower-order sensorimotor abilities are generally regarded as distinct and studied separately, there is evidence that they not only covary but also that this covariation increases across the lifespan. This pattern has been leveraged in clinical settings where a simple assessment of sensory or motor ability (e.g. hearing, gait speed) can forecast age-related cognitive decline and risk for dementia. However, the brain mechanisms underlying cognitive, sensory, and motor covariation are largely unknown. Here, we examined whether such covariation in midlife reflects variability in common versus distinct neocortical networks using individualized maps of functional topography derived from BOLD fMRI data collected in 769 45-year-old members of a population-representative cohort. Analyses revealed that variability in basic motor but not hearing ability reflected individual differences in the functional topography of neocortical networks typically supporting cognitive ability. These patterns suggest that covariation in motor and cognitive abilities in midlife reflects convergence of function in higher-order neocortical networks and that gait speed may not be simply a measure of physical function but rather an integrative index of nervous system health.

Topic: Functional Brain Connectivity Studies
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences