jimnoneill/paper-to-field-training huggingface dataset:
Abstract A138: Increased CD3(+) cell infiltration during pancreatic intraepithelial neoplasia progression in <i>KrasG12D</i>/Pdx1-Cre transgenic mouse model

Abstract This study aim to quantify the dynamic number changes of CD3(+) lymph cells in a pre-malignant stage of pancreatic cancer, namely, pancreatic intraepithelial neoplasia (PanIN). The experiment was conducted using a well-established KrasG12D/Pdx1-Cre transgenic mouse model. The animal model expressed a pancreas-specific active KrasG12D gene, resulting in PanIN progression and acinar structure loss in a time dependent manner. Experiment mice were sacrificed at 5, 7, 9, and 11 months (n = 3 for each time point). The pancreas tissues were fixed and stained by a rabbit monoclonal [EPR4517] to CD3G (Abcam Cat#: ab134096, 1:500 dilution). The CD3(+) lymph cell number were quantified by Leica optical system and the CD3(+) lymph cells were manually counted (ten fields for each mouse). All experimental conducted were approved by the ethical committee. The CD3(+) lymph cell number was calculated by averaging all field in each time point (thirty fields per time point). The number was then presented as mean ± SEM. Quantitatively, the CD3(+) cell were 11.73 ± 2.83, 14.23 ± 2.07, 14.90 ± 1.99, and 29.13 ± 2.04 per field in 5, 7, 9, and 11 month-old mice. The CD3(+) cell number was not significantly different among 5, 7, and 9 month-old mice. However, the number significantly increase in the 11 month-old mice compared with the 9-month ones (P&amp;lt; 0.0001, unpaired t-test). We observed that CD3(+) lymph cells were predominately present in PanIN area, while almost not observable in the remaining normal acinar area. The phenomenon that CD3(+) lymph cells infiltrate in PanIN area indicates that this type of immune cells may involve in PanIN progression. Citation Format: Xiafei Hong, Hongmei Dai, Xianze Wang, Feng Tian, Wenming Wu, Yupei Zhao. Increased CD3(+) cell infiltration during pancreatic intraepithelial neoplasia progression in KrasG12D/Pdx1-Cre transgenic mouse model [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr A138.

Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Childhood immunization, homeopathy and community nurses

The way for community nurse practitioners to promote medical childhood immunization to parents, is for them to become fully conversant with both alternative and traditional medical approaches to this issue. A brief overview of homoeopathy and its approaches to immunization is outlined highlighting the current debate for and against anti-medical and medical immunization. Arguments are put forward supporting medical immunization and the challenges this presents for nurses practitioners.

Topic: Vaccine Coverage and Hesitancy
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Woodland key habitats in northern Europe: concepts, inventory and protection

Abstract The woodland key habitat (WKH) concept has become an essential instrument in biodiversity-orientated forest management in northern Europe. The philosophy behind the concept is basically the same in all of the countries: to conserve the biodiversity of production landscapes by preserving small habitat patches that are supposed to be particularly valuable. This article reviews the definitions, inventories and implementation processes of WKHs in Sweden, Finland, Norway, Latvia, Estonia and Lithuania. Sweden and the Baltic countries have similar WKH models, while the models in Finland and Norway are clearly deviating. Depending on the country, the definitions emphasize different factors, such as soil and bedrock properties, stand structure and occurrence of indicator species. The mean size of the WKHs varies considerably, from 0.7 ha (Finland) to 4.6 ha (Sweden). The degree of formal protection also differs. Preservation of WKHs is primarily based on forest legislation in Finland, Estonia and Latvia, and on forest certification in the other countries. The implementation of the WKH concept is inconsistent between the countries, resulting in different sets of habitats being included in the WKH networks. This makes direct comparisons between the countries difficult, and may hamper the generalization of research results into other areas.

Topic: Forest Ecology and Biodiversity Studies
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Association Of Serial Beta HCG And Progesterone Level With Outcome In Pregnancy Of Unknown Location

Objective: To study the association of change in serial beta HCG level over 48 hours and serum progesterone with final diagnosis i.e. viable intrauterine pregnancy, ectopic pregnancy or failing pregnancy in cases initially labelled as pregnancy of unknown location. Study Design: prospective population based study Place and duration of study: Early Pregnancy Assessment unit of Homerton University Hospital London from December 2013 to February 2014 Methodology: Fifty patients were recruited in the study who presented to early pregnancy assessment unit and had positive urine for pregnancy test but no evidence of pregnancy on transvaginal scan. Initial beta HCG, progesterone and transvaginal scan were done in all cases. Patients were followed up with repeat HCG at 48 hour interval and repeat TVS until final diagnosis was established. Results: Final diagnosis was miscarriage 58%, viable intrauterine pregnancy 24% and ectopic pregnancy 12%. 67% of patients with rise in HCG &gt;60% had viable intrauterine pregnancy whereas all patients with &gt;50% fall in HCG had a miscarriage. A highly significant association of &gt;60% rise of HCG with viable intrauterine pregnancy and of &gt;50% fall in HCG with miscarriage was observed with p-value&lt;0.0001. 58% of patients with progesterone &gt;30 had viable intrauterine pregnancy whereas 83% of patients with progesterone &lt;10 were miscarriage and 17% had ectopic pregnancy. A highly significant association of final diagnosis of viable intrauterine pregnancy and progesterone level &gt;30 was observed with p-value&lt;0.0001. Conclusion: Although there is high association of &gt;60% rise in 48 hour repeat HCG and progesterone &gt;30 with viable intrauterine pregnancy, ectopic pregnancy cannot be ruled out on the basis of biochemical test. Therefore a high index of suspicion is required to diagnose cases of ectopic pregnancy using clinical signs and symptoms, transvaginal scan as well as biochemical tests such as serial beta HCG and progesterone levels.

Topic: Ectopic Pregnancy Diagnosis and Management
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
INTER-ARM BLOOD PRESSURE DIFFERENCE

Objective: An increased inter-arm systolic blood pressure difference (IBPD) is an easily determined physical examination finding and a significant IBPD has recently been associated with worse cardiovascular outcome. But the prevalence of IBPD in Asian population is unknown and the relationship between IBPD and blood pressure (BP) variability is not yet determined. This study was performed to describe the prevalence and clinical characteristics of the patients with increased IBPD and to examine the association between IBPD and BP variability.Design and method: A representative population (aged 20–65 years) was selected by list-assisted random-digit dialing method from a city with a population of one million. The BP of two arms was simultaneously measured using validated automatic BP measurement devices for 3 times and ambulatory blood pressure monitoring (ABPM) was performed in all included subjects. An increased IBPD was defined as > 10mmHg using the average of 3 BP differences obtained simultaneously in both arms. Results: Five hundreds of subjects were included in this study, and 13 subjects were excluded because of inadequate ABPM measurements. Mean age was 46.9 ± 9.4 years and 309 participants were female (63.4%). Overall systolic BP and diastolic BP were 118.5 ± 13.4 mmHg and 75.1 ± 10.3 mmHg and mean systolic IBPD was 5.7 ± 4.0mmHg. Of 487 subjects, 66 subjects (13.6%) had an increased systolic IBPD. Compared with those with normal IBPD, subjects with increased systolic IBPD showed higher clinic BP (127.2 ± 13.7 vs. 117.2 ± 12.8 mmHg in systolic BP, P < 0.001; 78.7 ± 11.2 vs. 74.6 ± 10.1 mmHg in diastolic BP, P = 0.002), higher 24-hour systolic BP (118.5 ± 12.0 vs. 115.6 ± 10.8 mmHg, P = 0.045) and higher 24-hour pulse pressure (42.4 ± 7.4 vs. 40.2 ± 6.5 mmHg, P = 0.012). The subjects with increased systolic IBPD showed higher 24-hour BP variability; increased standard deviation of daytime BPs, increased weighted standard deviation of BPs, increased coefficient of variation of daytime BPs and increased average real variability of both 24-hour BPs and daytime BPs (Table). There was no significant difference in nighttime dipping pattern of increased IBPD subjects. Conclusions: In this community-based cohort, an increased IBPD is common and associated with an increased short-term BP variability. Bilateral BP measurements should be emphasized in routine clinical practice.

Topic: Blood Pressure and Hypertension Studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Linear independence of indefinite iterated Eisenstein integrals

We prove linear independence of indefinite iterated Eisenstein integrals over the fraction field of the ring of formal power series $\mathbb{Z}[[q]]$. Our proof relies on a general criterium for linear independence of iterated integrals, which has been established by Deneufch{â}tel, Duchamp, Minh and Solomon. As a corollary, we obtain $\mathbb{C}$-linear independence of indefinite iterated Eisenstein integrals, which has applications to the study of elliptic multiple zeta values, as defined by Enriquez.

Topic: Advanced Mathematical Identities
Subfield: Algebra and Number Theory
Field: Mathematics
Domain: Physical Sciences
Study on the Imaging Interference of a Vortex-Light-Modulated Gaussian Beam

Combined with vortex light and airglow, some different physical phenomena are presented in this paper. Based on the ground-based airglow imaging interferometer (GBAII) made by our group, a liquid crystal on silicon (LCoS) device on one arm of a wide-angle Michelson interferometer (MI) of the GBAII is replaced by the reflector mirror to become the GBAII-LCoS system. LCoS generates a vortex phase to convert a Gaussian profile airglow into a vortex light pattern. After the Gaussian profile vortex light equation is obtained by combining the Gaussian profile airglow with the Laguerre–Gauss light, three different physical phenomena are obtained: the simulated Gaussian vortex airglow beam exhibits a hollow phenomenon with the introduction of the vortex phase, and as the topological charge (TC) l increases, the hollow range also increases; after adding the vortex factor, the interference fringe intensity can be ‘broadened’ with the optical path difference (OPD) and TC l increases, which match the field broadening technology for solid wide-angle MI; the ‘Four-point algorithm’ wind measurement for the upper atmosphere based on the vortex airglow is derived, which is different from the usual expressions. Some experimental results are presented: We obtained the influence modes of vortex light interference and a polarization angle from 335° to 245°. We also obtained a series of interference images that verifies the rotation of the vortex light, onto which is loaded a set of superimposed vortex phase images with TC l = 3 into LCoS in turn, and the interference image is rotated under the condition of the polarization angle of 245°. The controlled vortex interference image for different TC and grayscale values are completed.

Topic: Orbital Angular Momentum in Optics
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Clinical treatment of ectodermal dysplasia: a case report.

Ectodermal dysplasia is both physically and emotionally devastating to patients. With proper restorative intervention, the quality of life can be improved for patients with ectodermal dysplasia. This case report outlines a method of restoring function and esthetics for a 14-year-old boy with ectodermal dysplasia. It is important that these patients be treated at an early age to aid in their social interactions.

Topic: dental development and anomalies
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Busting a myth with the Bayes Factor: Effects of letter bigram frequency in visual lexical decision do not reflect reading processes

Psycholinguistic researchers identify linguistic variables and assess if and how these affect cognitive processes. One such variable is letter bigram frequency, or the frequency with which a given pair of letters co-occurs in an orthography. While early studies have shown that bigram frequency affects visual word recognition, subsequent, well-controlled studies have failed to show such an effect. Still, researchers continue to use it as a control variable in psycholinguistic experiments. We propose two reasons for the persistence of this variable: (1) Studies have reported no evidence for an effect of bigram frequency, but this cannot provide evidence for no effect. (2) The theoretical implications of a bigram frequency have been largely neglected. We address the first issue by performing Bayes Factor tests on both a matched item set and large-scale studies, and the second by discussing possible theoretical implications. We find no effects of bigram frequency effects for lexical decisions, though there is some evidence for an effect in reading aloud.

Topic: Reading and Literacy Development
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
The Restorative Justice Attitudes Scale: Development and Initial Psychometric Evaluation

Restorative justice as an applied and theoretical construct has received growing public attention; yet, little research on restorative justice has been conducted within psychology, including counseling psychology—a subfield devoted to social justice, advocacy, and the promotion of human rights and dignity for all people. This may in part be due to the lack of established empirical measurement concerning restorative justice. We developed the Restorative Justice Attitudes Scale (RJAS) using data collected from 650 US adults. Exploratory analyses yielded a 5-factor structure composed of 20 items within five dimensions: (a) Empathic Understanding, (b) Harm and Needs, (c) Restoration Processes, (d) Accountability, and (e) Community Engagement. However, confirmatory analyses suggested the use of a total scale score. Evidence of construct validity was established as the RJAS score was related to measures of empathy and perspective-taking. We discuss implications for the use of the RJAS in practice, advocacy, education, training, and research.

Topic: Criminal Justice and Corrections Analysis
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Incorporation of Axial Chirality into Phosphino-Imidazoline Ligands for Enantioselective Catalysis

A complementary strategy for ligand tuning that enables controlling ligand conformation is described here. The concept is demonstrated with new ligands that are employed in the catalytic enantioselective preparation of the highly important C2-aminoalkyl five-membered heterocycle motif. The alkynylation/cyclization sequence developed here is convergent, highly modular, and allows for a complementary scope to the heteroarylation of imines. This new ligand platform should offer new possibilities for expanding the use of PHIM-type ligands in a large variety of new transformations.

Topic: Asymmetric Synthesis and Catalysis
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Chapter 5. Omics for the Identification and Characterization of Foodborne Pathogens

Foodborne disease is caused in great part by the ingestion of food contaminated with bacterial pathogens, representing a serious but also largely preventable global burden. The detection of the most important foodborne pathogens forms a main part of risk assessment systems to guarantee food safety. No less important is the investigation of foodborne outbreaks, including effective source-tracking and obtaining information about epidemiology, virulence and antibiotic resistance. This chapter reviews the application of omics as powerful tools for screening and subtyping of the most relevant foodborne pathogenic bacteria in foodstuffs and carrying out robust risk assessment in the field of food safety. The approaches discussed include genomics, proteomics and metabolomics, giving special attention to high-throughput techniques, such as next-generation sequencing and mass spectrometry.

Topic: Identification and Quantification in Food
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Mechanism Analysis of Small Box Girder Diseases and Summary of Reinforcement Treatment Strategies

Abstract With the vigorous development of bridge construction in China, the structure of bridges is also more abundant. Among them, the prefabricated small box girder has been widely used in engineering fields at home and abroad due to its large section torsional strength, bending strength, and low cost and fast construction speed. However, due to poor design and improper construction in the early stage, coupled with the vehicle over-aging and inadequate material maintenance, the prefabricated small box girder bridges have different degrees of disease, how to study the disease generation mechanism and take targeted reinforcement. The treatment strategy is related to the safety of transportation in China. In this paper, the statistical analysis of the disease of small box girder in active service is carried out, and the mechanism of various diseases is analyzed and summarized. On this basis, the common methods of reinforcement and treatment of small box girder in China are comprehensively analyzed. The research results of this paper have important reference value for mastering the causes of the disease of small box girder in China’s expressway and the corresponding reinforcement strategy.

Topic: Concrete Corrosion and Durability
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
What does my left hand know?

Tiger, tiger burning bright In the forests of the night What immortal hand or eye Could frame your fearful symmetry Symmetry seems to be a desirable property, yet wherever we look we find asymmetry. This paper explores the presence and nature of asymmetry in biological systems.

Topic: Origins and Evolution of Life
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Problematic fossils from the Upper Cretaceous of western Bulgaria might be the first record of Mesozoic insects in the country

Recent work at the Upper Cretaceous vertebrate locality near the town of Tran, western Bulgaria, brought to light a diverse assemblage of plant mesofossils and other microfossils of uncertain systematic affinities. Here we briefly report on 18 problematic specimens that share a striking morphological similarity to the Late Cretaceous Knoblochia cretacea, an ichnotaxon thought to be an insect egg. This material appears to represent the first record of Mesozoic insects from Bulgaria.

Topic: Fossil Insects in Amber
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Public attitudes on transgender military service : The role of gender

Policy regarding the inclusion of transgender soldiers in the U.S. Military has shifted back and forth in recent years, with public opinion likely a significant factor shaping the eventual policy outcome. As such, this study examines the factors that shape public attitudes toward military service by transgender people. In particular, we examine the influence of sex, social gender roles, and attitudes toward gender in shaping transgender military service attitudes. Further, we hypothesize that personal experiences with the military and with transgender people, along with values, personality predispositions, and religion, are likely to influence individual attitudes. We test these hypotheses using data from a unique October 2015 national survey of American adults. The results suggest that personal experiences, attitudes toward gender roles, and religion have substantial but sometimes conditional effects on attitudes toward military service by transgender people.

Topic: LGBTQ Health, Identity, and Policy
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
The effect of bank regulation on performance of private commercial banks in Ethiopia

The financial system plays a pivotal role in economic activities in any country. Thus it is vital to determine the status and assess the financial health of the financial system and take corrective policy measures continuously. The main objective of the study is to examine the effect of bank regulation on the performance of private commercial banks. The study used balanced panel model in examining the regression model and collect data from ten private commercial banks covering the period of six (6) consecutive years, 2011-2016with a total of 60 observations. To this end, the study employed a quantitative research approach by documentary analysis based on their audited financial statement. The study used panel data techniques specifically fixed effect model on the regression analysis and used E-view8 software. The study used two dependent variables return on asset (ROA) and return on equity (ROE), six independent variables that are NBE bill purchase, legal reserve requirement, equity investment, capital requirement, capital adequacy and bank size. The findings of the study for ROA model revealed that NBE Bill Purchase and Legal reserve requirement have negative and significant effect on performance of private commercial bank in Ethiopia, where as equity investment, capital requirement, bank size and capital adequacy are positive and significant effect on performance of private commercial bank in Ethiopia. The regression result of the second performance indicator ROE model revealed that NBE Bill Purchase and Legal reserve requirement have negative and significant effect on performance of private commercial bank in Ethiopia, where as equity investment, capital requirement, bank size and capital adequacy are positive and significant effect on performance of private commercial bank in Ethiopia. The research concluded that NBE regulation has significant effect on the performance of Ethiopian private commercial banks. Hence, the study recommend in support of each variables for Ethiopian private commercial banks to give due attention on NBE regulation to enhance their performance significantly.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
ChemInform Abstract: Stereoselective Transformation of Aryloxyepoxy Alcohols: Preparation of Functionalized Chromanes.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Synthesis of Organic Compounds
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences