jimnoneill/paper-to-field-training huggingface dataset:
Warts, cancer and ubiquitylation: lessons from the papillomaviruses.

Certain human papillomaviruses (such as HPV-16 and HPV-18) are associated with specific anogenital cancers, most notably cervical cancer. These viruses encode two oncoproteins, E6 and E7, which are expressed in the HPV positive cancers. E7 functions in cellular transformation, at least in part, through inactivation of pRB, and the other pRB related "pocket proteins" p107 and p130. The major target of the E6 oncoprotein encoded by the genital tract, cancer-associated human papillomaviruses is the p53 tumor suppressor protein. E6 binding to p53 is mediated by a cellular protein, the E6-associated protein (E6AP). In the presence of E6, E6AP catalyses the ubiquitylation and proteolysis of p53. E6AP is an E3 ubiquitin protein ligase and is not normally involved in the regulation of p53 stability in the absence of E6. E6AP is the prototype for the HECT domain family of E3 ubiquitin protein ligases.

Topic: Cervical Cancer and HPV Research
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Relational Energy: A moderated mediation model of Leader-Member Exchange on Job Satisfaction

Interactions with others at work can leave us feeling energized, or not. Relational energy, which is defined as the heightened level of psychological resourcefulness generated from interpersonal interactions that enhances one’s capacity to do work, has been related to a range of positive outcomes. As the notion of relational energy gains momentum in the literature, it remains unclear how relational energy relates to outcomes and where it comes from. Past research has demonstrated that the Leader-Member Exchange (LMX) relationship plays a pivotal role in enhancing employee job satisfaction. In this paper, we examine how and when LMX relates to employee job satisfaction by examining relational energy from supervisor as a mediator and relational energy from co-workers as a boundary condition. We test our theoretical model using a sample of 211 employees nested in 17 teams. Results support our moderated-mediation model.

Topic: Job Satisfaction and Organizational Behavior
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
BIOCHEMICAL CHARACTERIZATION AND EFFECT OF BACTERIAL BLIGHT ON MICRO AND MACRO NUTRIENT CONCENTRATION IN POMEGRANATE

Bacterial blight is a serious disease of pomegranate. The disease affects the yield and quality of pomegranate fruits. In this present work, we investigated the biochemical characterization and role of micro and macro nutrients in diseased and healthy leaves of pomegranate. Pathogen was isolated infected leaves, twigs and fruits and grown on different culture media. Different biochemical tests (Gram staining, KOH, catalase, oxidase, starch hydrolysis, gelatin liquefaction) were performed to identify the bacteria. All these tests confirm the presence of Xanthomonas axonopodis pv punicae. Pathogenicity was done in the greenhouse using three different methods (Pin-pricked, infiltration and spray method) and symptoms appeared in 8 days; and infiltration method showed early symptoms compared to the spray and pin prick method. Ionic contents (Nitrogen, Potassium, Phosphorus, Magnesium, Calcium, Iron, Boron, Zinc and Copper) are reduced by using these nutrients for the growth, multiplication and survival of pathogenic bacteria. Proper application of these nutrients helps the host plant to improve its physiological and biochemical development and resistance to bacterial blight disease in pomegranate.

Topic: Banana Cultivation and Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Strengthened stability analysis of discrete-time Lurie systems involving ReLU neural networks

This paper addresses the stability analysis of a discrete-time (DT) Lurie system featuring a static repeated ReLU nonlinearity. Such systems often arise in the analysis of recurrent neural networks and other neural feedback loops. Custom quadratic constraints, satisfied by the repeated ReLU, are employed to strengthen the standard DT Circle and DT Popov Criteria for this specific Lurie system. The criteria can be expressed as a set of linear matrix inequalities (LMIs) with less restrictive conditions on the matrix variables. It is further shown that if the Lurie system under consideration has a unique equilibrium point at the origin, then this equilibrium point is in fact globally stable or unstable, meaning that local stability analysis will provide no additional benefit. Numerical examples demonstrate that the strengthened criteria achieve a desirable balance between reduced conservatism and complexity when compared to existing criteria.

Topic: Neural Networks Stability and Synchronization
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
The effectiveness of blended learning to improve pre-service teacher TPaCK in developing multimedia learning mathematics at elementary school

Abstract This study aims to determine the effectiveness of blended learning towards the improvement of pre-service teacher TPaCK (Technological Pedagogical Content Knowledge) in developing multimedia learning mathematics in elementary schools. The type of this research is a quasi-experimental design. The research method used is a non-equivalent control group design. The population of this study was the 6th-semester students of the 2018/2019 academic year of the PGSD UAD study program of 315 students grouped in 7 classes. The sample used was an experimental class of the class controller drawn at random. The method of collecting data uses observations in multimedia learning mathematics that have been developed by pre-service elementary school teachers. The research instrument used the TPaCK assessment sheet that had been taken expert validation. The results of the study showed that at a significance level of 5% blended learning was effective in increasing the TPaCK of pre-service teachers in developing multimedia learning mathematics in elementary schools.

Topic: Mathematics Education and Pedagogy
Subfield: Applied Mathematics
Field: Mathematics
Domain: Physical Sciences
Corynebacterium Jeikeium Endocarditis: A Review of the Literature

Corynebacterium jeikeium is a gram-positive, aerobic, pleomorphic, nonspore forming bacillus, commonly present on the skin surface. Infective endocarditis secondary to C. jeikeium most commonly affects left-sided heart valves and has a higher likelihood to require valve replacement compared to other Corynebacterium endocarditis. C. jeikeium endocarditis is extremely difficult to treat as it is characteristically resistant to penicillin, cephalosporins and aminoglycosides, and sensitivity to quinolones, macrolides, tetracyclines and rifampin is variable. Despite treatment, mortality rates as high as 33% have been reported. We hereby review the literature regarding the epidemiology, diagnosis and treatment of this deadly microorganism.

Topic: Diphtheria, Corynebacterium, and Tetanus
Subfield: Endocrinology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Analysis of Muslim-Friendly Tourism Potential in Padang Ganting Hot Spring Tourism, Tanah Datar District, West Sumatra, Indonesia

Purpose: This study aims to analyze the potential of Muslim-friendly tourism and the obstacles to its implementation at the Padang Ganting hot spring tourist destination in Tanah Datar Regency West Sumatera Indonesia. The focus of the research is to identify the four components of Muslim-friendly tourism destinations with the standardization issued by Indonesia Muslim Travel Index (IMTI). They are Accessibility (access), Communication (communication), Environment (environment), and Service (service) Methods: Data were collected by using observation, in-depth interviews and document studies. Furthermore, the data that has been collected will be analyzed using descriptive qualitative analysis techniques. Result: The results show that the potential of Muslim-friendly tourism in the Padang Ganting hot spring is quite large, although there are still obstacles with the following indications: 1) potential Access, that is the road has been paved but is still narrow for four-wheeled vehicles or buses to pass, parking lots and roads exit still needs improvement. 2) The communication aspect includes Muslim-friendly information services through posters and stakeholder training by the district government of Tanah Datar regency, however, is still not geared towards Muslim-friendly tourism and no digital marketing has been carried out. 3) Environmental aspects have supported Muslim tourists but Wi-Fi service is not yet available. 4) There are services and facilities for Muslim tourists but there is no halal food certification, Ramadan services and the need to improve environmental hygiene. Benefits/Contributions: This research is expected to add to knowledge, especially in the analysis of Muslim-friendly tourism potential in a tourist destination. Contribution: This research can contribute to knowledge, particularly with regard to examining the potential for Muslim-friendly tourism in a tourist destination.

Topic: Halal products and consumer behavior
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
CHARACTERISTICS OF CHOROIDAL NEOVASCULARIZATION IN THE COMPLICATIONS OF AGE-RELATED MACULAR DEGENERATION PREVENTION TRIAL

Tufts University School of Medicine Boston, MA Original study reprint requests: CAPT Coordinating Center, University of Pennsylvania, 3535 Market Street, Suite 700, Philadelphia, PA 19104-3309.

Topic: Retinal Diseases and Treatments
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Do outreach activities in secondary STEM education motivate students and improve their attitudes towards STEM?

The present study investigated outreach activities, developed by STEM-based companies or universities in co-creation with secondary education with the aim to inform students about and motivate them for a career in STEM by connecting the work-context with school-science. Although many of such activities are being offered, little is known about their effects. We investigated students’ perceptions with the outreach learning environment, perceived need-fulfilment, self-reported motivation and attitudes towards STEM. Data were gathered from 729 high-school students engaged in 12 activities in the USA and the Netherlands. The students completed a questionnaire, which contained questions about four elements of our theoretical frame based on the Self-Determination-Theory (SDT). Perceived needs-fulfilment and motivation were measured using the basic-psychological-needs-scale and the self-regulation-questionnaire. Attitudes were measured using the test-of-science-related-attitudes. Learning environment perceptions were measured in a previous study using subscales of what-is-happing-in-this-classroom (WIHIC), constructivist-learning-environments-scale (CLES) and classroom-environment-scale (CES) and typified by activity characteristics. Multilevel analyses of variance were conducted for the two motivation scales (controlled and autonomous-motivation) and the two attitude scales (social-implication and career-interest). Activity characteristics explained almost all variance in these variables between activities. Specific characteristics of outreach activities that statistically significantly related to autonomous motivation and positive general attitudes towards STEM were: workshop-format, understanding science, an out-of-school component. The attitude towards a possible STEM-career was positively associated with autonomous-motivation and negatively associated with controlled-motivation. Thus, outreach learning environments indeed created opportunities to increase students’ motivation in STEM and attitude towards STEM, but the impact varied according to particular characteristics of the activities.

Topic: Motivation and Self-Concept in Sports
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Effects of Lithium on the Hypothalamo-Pituitary-Adrenal Axis.

The effect of lithium on the hypothalamo-pituitary-adrenal axis was studied in vivo and in vitro. The levels of plasma vasopressin, ACTH and corticosterone increased after the administration of lithium (LiCl 4 mmol/kg BW, 11 days) in rats, while the tissue vasopressin concentration in the median eminence, the rest of the hypothalamus and the posterior pituitary was decreased. The CRF concentration in the posterior pituitary increased markedly, but it did not change significantly in the median eminence or the rest of the hypothalamus. The elevated plasma ACTH level might be at least partly due to the increased vasopression secretion. Lithium stimulated ACTH secretion per se and also enhanced vasopressin-induced ACTH secretion in cultured pituitary cells and in half pituitary incubations, while it did not affect CRF-induced ACTH secretion. Lithium inhibited CRF-induced cAMP accumulation in half pituitary incubations, while lithium and vasopressin did not affect cAMP accumulation per se or even when administered together. The results suggest that lithium-induced ACTH release is via a cAMP-independent mechanism. Thus, it is possible that lithium stimulates ACTH release by acting directly on the corticotroph, stimulating vasopressin release and potentiating vasopressin-induced ACTH release.

Topic: Stress Responses and Cortisol
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
A Mechanistic Link between<i>STM</i>and<i>CUC1</i>during Arabidopsis Development

Abstract The KNOXI transcription factor SHOOT MERISTEMLESS (STM) is required to establish and maintain the Arabidopsis (Arabidopsis thaliana) apical meristem, yet little is known about its direct targets. Using different approaches we demonstrate that the induction of STM causes a significant up-regulation of the organ boundary gene CUP SHAPED COTYLEDON1 (CUC1), which is specific and independent of other meristem regulators. We further show that the regulation of CUC1 by STM is direct and identify putative binding sites in its promoter. Continuous expression of STM in Arabidopsis leaf primordia also causes the activation of CUC2-3, as well as microRNA MIR164a, which provides a negative feedback loop by posttranscriptionally regulating CUC1 and CUC2. The results bring new insights into the mechanistic links between KNOXI and CUC transcription factors and contribute to the understanding of the regulatory network controlled by STM.

Topic: Plant Molecular Biology Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Seasonal Variation of Hordenine and Gramine Concentrations and Their Heritability in Reed Canarygrass<sup>1</sup>

The antiquality tryptamine alkaloids and their β‐ carboline derivatives in reed canarygrass, Phalaris arundinacea L., are under relatively simple genetic control and can be eliminated by breeding. The nontryptamine alkaloids (hordenine and gramine) are more difficult remove because they can only be controlled genetically by lowering their concentrations. The objectives of this study were to determine seasonal variation of hordenine concentration, its heritability, and relationship to gramine concentration in reed canarygrass. Our studies showed high broad sense heritability estimates for hordenine and gramine of first growth and regrowth forage, a statistically significant but low positive correlation between the two alkaloids, and similar seasonal variation in their concentration. Concentration of gramine (7,000 µg/g dry wt) in regrowth forage was 10 times greater than that in first growth; concentration of hordenine (3,200 µg/g dry wt) in regrowth was twice greater than that in first growth (mean of 155 plants). Leaf blades contained higher concentrations of gramine than did leaf sheaths, whereas the converse was true for hordenine. The upper portion of the canopy contained 69% and 48% of mean herbage concentrations of gramine and hordenine, respectively. Improved techniques for extraction and colorimetric determination of the alkaloids are detailed, and the presence of nor ‐gramine is reported.

Topic: Bioenergy crop production and management
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
On the inscription of a triangle of given shape in a given triangle

§ 1. To inscribe in a triangle ABC a triangle similar to the triangle DEF, and having its sides parallel to those of DEF. In order to inscribe in the triangle ABO (fig. 21), a triangle having its sides parallel to those of DEF, through D, E, F, draw lines parallel to the sides of ABC, and then reduce the figure A′B′C′ in the ratio BC : B′C′.

Topic: Mathematics and Applications
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Small-World Connections to Induce Firing Activity and Phase Synchronization in Neural Networks

We investigate how the firing activity and the subsequent phase synchronization of neural networks with small-world topological connections depend on the probability p of adding-links. Network elements are described by two-dimensional map neurons (2DMNs) in a quiescent original state. Neurons burst for a given coupling strength when the topological randomness p increases, which is absent in a regular-lattice neural network. The bursting activity becomes frequent and synchronization of neurons emerges as topological randomness further increases. The maximal firing frequency and phase synchronization appear at a particular value of p. However, if the randomness p further increases, the firing frequency decreases and synchronization is apparently destroyed.

Topic: Neural Networks and Applications
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Providing better understanding of the true revenues of the organization.

In this commentary, the author suggests that current trends in the healthcare industry have made the traditional approach to recording patient service revenue inadequate. He feels the guidelines set forth in the following Principles and Practices Board statement, "The Presentation of Patient Service Revenues and Related Issues," is a more useful way to present the "true" revenues of the healthcare organization.

Topic: Healthcare Policy and Management
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Zigeuner fordern Volksgruppen-Status

e d e r g esch ich tlich en E n t w ic k lu n g a u f d e m B a lk a n a u fta u c h te , u n d z w ar n a c h d e r U n te rz e ich n u n g d e s u n g lü c k se lig e n B e rlin e r V e rtra g s v o n 1878, d

Topic: Romani and Gypsy Studies
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
A more productive, but different, ocean after mitigation

Abstract Reversibility studies suggest a lagged recovery of global mean sea surface temperatures after mitigation, raising the question of whether a similar lag is likely for marine net primary production (NPP). Here we assess NPP reversibility with a mitigation scenario in which projected Representative Concentration Pathway (RCP) 8.5 forcings are applied out to 2100 and then reversed over the course of the following century in a fully coupled carbon‐climate Earth System Model. In contrast to the temperature lag, we find a rapid increase in global mean NPP, including an overshoot to values above contemporary means. The enhanced NPP arises from a transient imbalance between the cooling surface ocean and continued warming in subsurface waters, which weakens upper ocean density gradients, resulting in deeper mixing and enhanced surface nitrate. We also find a marine ecosystem regime shift as persistent silicate depletion results in increased prevalence of large, non‐diatom phytoplankton.

Topic: Marine and coastal ecosystems
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
BILATERAL PHEOCHROMOCYTOMA.

We report a case of bilateral adrenal pheochromocytoma in a young, male patient who consulted for arterial hypertension. The adrenal tumors had been accurately diagnosed by abdominal ultrasonography and confirmed by CT. The incidence of bilateral involvement in pheochromocytoma is briefly discussed and the methods currently utilized for topographic localization of the tumor are described.

Topic: Adrenal and Paraganglionic Tumors
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Clerical Misconduct in the Church of Sweden 2000–2004

The Church of Sweden, being the national Lutheran Church, was disestablished in 2000 and former state obligations were transferred to the church. Major changes were effected in the oversight of the clergy and all complaints were thereafter to be handled by the church itself. This article considers empirical data concerning those complaints and makes an evaluative comparison with the previous system.

Topic: Theology and Canon Law Studies
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
A Game Theoretic Model for Aggregate Bypassing Behavior of Vehicles at Traffic Diverges

Vehicle bypassing is known to negatively affect delays at traffic diverges. However, due to the complexities of this phenomenon, accurate and yet simple models of such lane change maneuvers are hard to develop. In this work, we present a macroscopic model for predicting the number of vehicles that bypass at a traffic diverge. We take into account the selfishness of vehicles in selecting their lanes; every vehicle selects lanes such that its own cost is minimized. We discuss how we model the costs that are experienced by vehicles. Then, taking into account the selfish behavior of vehicles, we model the lane choice of vehicles at a traffic diverge as a Wardrop equilibrium. We state and prove the properties of Wardrop equilibrium in our model. We show that there always exists an equilibrium for our model. Moreover, unlike most nonlinear asymmetrical routing games, we prove that the equilibrium is unique under mild assumptions. We discuss how our model can be easily calibrated by running a simple optimization problem. Using our calibrated model, we validate it through simulation studies and demonstrate that our model successfully predicts the aggregate lane change maneuvers that are performed by vehicles for bypassing at a traffic diverge. We further discuss how our model can be employed to obtain the optimal lane choice behavior of vehicles, where the social or total cost of vehicles is minimized.

Topic: Traffic control and management
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Giant Proteinosomes As Scaffolds for Light Harvesting

Based\non an interfacial assembly strategy, a giant proteinosome\nwas successfully fabricated by using protein–surfactant as\nbuilding blocks, which formed a thin protein layer as a membrane.\nThis approach of making protein assemblies was very facile, and it\nwas very convenient to remove the templates of oil and get water-filled\nproteinosomes by dialysis. Through modifying acceptor and donor chromophores\non the protein monomers, an efficient artificial light-harvesting\nsystem was successfully fabricated on the proteinosome, which was\na scaffold for efficient light harvesting. Furthermore, the on–off\nswitchable energy transfer was realized by protein folding and unfolding.\nThe efficient artificial light-harvesting systems we designed as the\npotential platforms could be utilized for biomaterials.

Topic: Automotive and Human Injury Biomechanics
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences