jimnoneill/paper-to-field-training huggingface dataset:
Impact of glacial-lake paleofloods on valley development since glacial termination II: A conundrum of hydrology and scale for the lowstand Brahmaputra-Jamuna paleovalley system

To better define the base of the Brahmaputra River paleovalley, we analyzed an extensive borehole data set from the subaerial Bengal delta and a 255-km-long multichannel seismic survey along the modern river. The data reveal that the paleovalley floor is defined by a gravel unit containing boulder-sized clasts up to 30 cm in diameter, deposited after ca. 30 ka but before ca. 9 ka. Paleohydrology during that time and the previous glacial maximum was characterized by a weak monsoon and reduced river discharge, both of which are inconsistent with large valley formation. However, our work indicates that glacial-lake outburst floods sourced from the Tibetan reaches of the Brahmaputra were routed through the lowstand valley, producing megaflood-scale discharge capable of transporting gravel and cannibalizing the valley margins. The timing of these glacial-lake outburst flood–driven discharge events was coincident with valley development and explains the anomalously large width of the valley and basal gravel surface. Despite the underfit scale of Brahmaputra discharge following the last glacial period, a strengthening monsoon and high sediment discharge in the early Holocene subsequently contributed to the efficient infilling of the massive paleovalley by the mid-Holocene. In a sequence stratigraphic context, this work provides an example of a major unconformity that developed late in the eustatic cycle (i.e., during early transgression rather than an earlier, protracted response to sea-level lowering) and in response to a perturbation originating in the catchment instead of changing accommodation in the basin. As such, it represents a geologically instantaneous time surface that can be used as a marker for stratigraphic correlation but one that is not in phase with eustatic sea-level fall.

Topic: Geology and Paleoclimatology Research
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Damping Characteristics of an Undamped AN/SQS-26 Sonar Dome Section.

This technical memorandum presents the damping characteristics of an undamped AN/SQS-26 sonar dome section in air. The data will be used as a reference for data to be taken on damped AN/SQS-26 sonar dome sections of the same size. (Author)

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Supplementary Figure 1 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma

&lt;p&gt;PDF file - 34K, Schedule of treatment and monitoring:Patients received 3 vaccinations a biweekly interval, followed a delayed type hypersensitivity (DTH) skin test. After completing one cycle and if no progression of disease was confirmed on CT-scan, patients were eligible to receive a maximum of two more cycles and were followed up to 5 years. Abbreviations: Vx = visit x; M = month, D = day, W = week, Y = year, vacx = vaccination x; FU = follow-up; * follow-up visits were planned every 3 months; # CT-scans were planned every 6 months&lt;/p&gt;

Topic: Immunotherapy and Immune Responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Well-Being of High-Growth Women EntrepreneursQuantitative Systematic Literature Review

Despite the increasing gender equality commonplace in various life domains and evident in the business practices worldwide, there is still a rich body of research indicating gender-specific differences in entrepreneurship. In connection with that observation, this quantitative systematic literature review was held to identify the existing body of evidence on the subject of the well-being of high-growth women entrepreneurs. By means of an automatic and manual search of ProQuest and EBSCO Host, 51 articles published on the subject in 2002-2016 were located and analysed in regard to emerging themes. Based on that analysis, the themes of financial and support factors, gender biases about performance, gendered perceptions and expectations, and the role of individual factors and family support surfaced as significant contributors to female entrepreneurs’ business success and correspondingly, well-being. The implications of these findings and gaps in current research are discussed with reference to further potential research directions in the field.

Topic: Entrepreneurship Studies and Influences
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Contemporary Picture of Anxiety Manifestations in Children of Primary School Age

Theoretical research analysis shows that many authors have noted a positive effect of mild anxiety, called the optimal level of anxiety or adaptive anxiety on children development. A study conducted in 2010-2014 was designed to investigate the levels of anxiety in children of primary school age. The study involved 241 elementary school student aged 7 - 11 years. Anxiety was diagnosed by Children's Manifest Anxiety Scale, or CMAS, adapted by A.M. Prikhozhan. The article presents a statistical and qualitative analysis of anxiety manifestations throughout the primary school age. The study revealed the ratio of anxiety levels in primary school children from first to fourth grade, the results are compared with those of previous studies of anxiety. The research allowed to identify the main elementary school periods when children have higher anxiety and often need psychological help.

Topic: Psychology of Development and Education
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Extended and Contorted Conformations of Alkanediammonium Ions in Symmetrical α,α′,δ,δ′-Tetramethylcucurbit[6]uril Cavity

Binding interactions between symmetrical α,α',δ,δ'-tetramethylcucurbit[6]uril (TMeQ[6]) and a series of alkyldiammonium ions in aqueous solution and in the solid state were investigated by (1)H NMR spectroscopy, MALDI-TOF mass spectrometry, X-ray crystallography, and isothermal titration calorimetry (ITC). Their (1)H NMR spectra reveal that the actual binding behaviors vary depending upon the alkyl chain length. Their single-crystal X-ray diffraction analyses indicate the guest 1,2-ethanediammonium is located outside of the TMeQ[6] portal, while the other four alkyldiammonium guests can be accommodated in the TMeQ[6] cavity, forming 1:1 inclusion complexes. Most importantly, the long-chain alkyldiammoniums (1,8-octanediammonium and 1,10-decanediammonium) take a contorted conformation when bound within the TMeQ[6] cavity. Additionally, ITC experiments show that the complexation of the alkyldiammonium guests with TMeQ[6] is mainly enthalpy driven, which benefits from ion-dipole interactions.

Topic: Supramolecular Chemistry and Complexes
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
The Effects of Incidence of Care Needs in Households on Employment, Subjective Health, and Life Satisfaction among Middle‐aged Family Members

Abstract In this study, based on longitudinal data, we investigate whether Japanese middle‐aged men and women become less likely to have a job and whether their sense of well‐being decreases when they have a family member who needs care. We find a consistent negative impact of having a family member who needs care on employment, but no impact on subjective health and life satisfaction. Further, the differences‐in‐differences ( DID ) estimation, based on both unmatched and matched data, shows that the Long‐Term Care Insurance ( LTCI ) introduced in 2000 did not mitigate the adverse impact on the probability of being employed.

Topic: Intergenerational Family Dynamics and Caregiving
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
<i>De Novo</i> Engineering of <i>Corynebacterium glutamicum</i> for <scp>l</scp>-Proline Production

l-Proline is an important amino acid that has various industrial applications. Industrial l-proline-producing strains are obtained by the mutagenesis of <i>Corynebacterium glutamicum</i>. In this study, the optimized <i>C. glutamicum</i> genome-editing tools were further applied in the <i>de novo</i> construction of a hyper-l-proline-producing strain. Overexpression of a feedback inhibition-resistant γ-glutamic kinase mutant ProBG149K, deletion of a proline dehydrogenase to block l-proline degradation, overexpression of glutamate dehydrogenase to increase glutamate synthesis flux, the mutation of 6-phosphate gluconate dehydrogenase and glucose-6-phosphate-dehydrogenase in the pentose phosphate pathway to enhance NADPH supply, the deletion of pyruvate aminotransferase to decrease the byproduct l-alanine synthesis, and weakening of α-ketoglutarate dehydrogenase to regulate the TCA cycle were combined to obtain ZQJY-9. ZQJY-9 produced 19.68 ± 0.22 g/L of l-proline in flask fermentation and was also demonstrated at the 3 L bioreactor level by fed-batch fermentation producing 120.18 g/L of l-proline at 76 h with the highest productivity of 1.581 g/L/h.

Topic: Microbial Metabolic Engineering and Bioproduction
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Bijections in weakly increasing trees via binary trees

As a unification of increasing trees and plane trees, the weakly increasing trees labeled by a multiset was introduced by Lin-Ma-Ma-Zhou in 2021. Motived by some symmetries in plane trees proved recently by Dong, Du, Ji and Zhang, we construct four bijections on weakly increasing trees in the same flavor via switching the role of left child and right child of some specified nodes in their corresponding binary trees. Consequently, bijective proofs of the aforementioned symmetries found by Dong et al. and a non-recursive construction of a bijection on plane trees of Deutsch are provided. Applications of some symmetries in weakly increasing trees to permutation patterns and statistics will also be discussed.

Topic: Graph theory and applications
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Resiliensi dan Burnout Akademik Mahasiswa Program Studi Bimbingan dan Konseling X

This study aims to: 1) describe the resilience level of students in the Guidance and Counseling (BK) study program at X; 2) describe the academic burnout level of students in the BK study program at X. This study uses a quantitative approach with a population of all active students in the BK study program. The research sample consisted of 14 students from semester II to semester VIII. The data collection technique used an instrument in the form of a questionnaire consisting of a resilience scale and an academic burnout scale. The results of the study indicate that on average, students in the BK Study Program at X have a high level of resilience. This finding is obtained from the average score of the resilience instrument that exceeds the cut-off/threshold of the CD-RISC or Resilience Scale, as well as the distribution of respondents who are mostly in the high resilience group. This condition indicates that students are relatively able to face academic pressure with a resilient, optimistic attitude, and are able to adapt to difficulties. This result indicates that resilience plays an important role in maintaining students' psychological well-being. Furthermore, the results of the study also show the distribution of academic burnout levels. Of the total respondents, 4 (25%) were in the low category, 9 (56.25%) in the moderate category, and 1 (6.25%) in the high category. The majority of students fell into the moderate category, meaning they experienced moderate levels of burnout symptoms, such as emotional exhaustion, decreased motivation, and feelings of being overwhelmed by work, but had not yet reached the chronic stage. In other words, academic burnout among students is present, but mostly at a moderate level. Based on the research and analysis, it can be concluded that students in the Guidance and Counseling Study Program at X have relatively high levels of resilience, while academic burnout levels tended to be in the moderate category, with a small percentage experiencing high levels.

Topic: Student Stress and Coping
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
A targeted screening method for peripheral arterial disease: a pilot study

Background Podiatrists play a central role in conducting non-invasive vascular foot assessment in the general population. Routine clinical assessment of lower limb arterial flow in at risk patients is essential in early detection and monitoring of the disease. There are a variety of clinical examinations available to clinicians in order to determine adequacy of blood supply to the lower extremity. However, recent research suggests that certain conditions, such as advanced age, diabetes, renal failure and medial arterial calcification can affect the accuracy of some of these examinations. Currently, there are no specific guidelines dictating the most appropriate methods of assessing lower limb vascular status for Podiatrists. The purpose of this study was to develop and validate a targeted vascular screening method for podiatrists.

Topic: Peripheral Artery Disease Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Automatic composition techniques for video production

Video production involves the process of capturing, editing and composing video segments for delivery to a consumer. A composition must yield a coherent presentation of an event or narrative. This process can be automated if appropriate domain-specific metadata are associated with video segments and composition techniques are established. Automation leads to the support of dynamic composition and customization for applications such as news on demand. In this paper, we present techniques to achieve dynamic, real-time and cohesive video composition and customization. We also identify metrics for evaluating our techniques with respect to existing manually produced video-based news. The results of such an evaluation show that the quality of automatic composition is comparable to-and in some cases, better than-broadcast news video composition. The results also validate the assertions on which the automatic composition techniques are based.

Topic: Multimedia Communication and Technology
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
A Physicalist Manifesto

A Physicalist Manifesto is a full treatment of the comprehensive physicalist view that, in some important sense, everything is physical. Andrew Melnyk argues that the view is best formulated by appeal to a carefully worked-out notion of realization, rather than supervenience; that, so formulated, physicalism must be importantly reductionist; that it need not repudiate causal and explanatory claims framed in non-physical language; and that it has the a posteriori epistemic status of a broad-scope scientific hypothesis. Two concluding chapters argue in detail that contemporary science provides no significant empirical evidence against physicalism and some considerable evidence for it. Written in a brisk, candid and exceptionally clear style, this 2003 book should appeal to professionals and students in philosophy of mind, metaphysics and philosophy of science.

Topic: Philosophy and History of Science
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences
Magnetic coordination clusters and networks: synthesis and topological description

With the discovery of the phenomenon of single-molecule magnetism, coordination chemists have turned their attention to synthesizing cluster aggregates of paramagnetic ions. This has led to a plethora of coordination clusters with various topologies and diverse magnetic properties. In this paper, we present ways of describing and understanding such compounds as well as outlining a new approach, which we have recently developed, to describing cluster topology. Our approach is based upon and pays tribute to the huge contribution made to coordination chemistry through the development of the Schläfli symbols for describing architectures. To illustrate the developments that are taking place in modern coordination chemistry, we start with some basic definitions of relevance to what follows. Then we describe approaches to discovering new magnetically interesting 3d/4f clusters, assigning their topological descriptions. Finally, we show how the concepts behind the construction of metal–organic frameworks can be extended to using clusters as nodes in the frameworks to give super metal–organic frameworks.

Topic: Magnetism in coordination complexes
Subfield: Electronic, Optical and Magnetic Materials
Field: Materials Science
Domain: Physical Sciences
Abstract 4596: Missense mutations in the p53 DNA-binding motifs (DBMs) are associated with shorter time to progression (TTP) in erlotinib-treated, EGFR-mutated patients

Abstract Background: Advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations has an average time to progression (TTP) of 14 months (mo) and overall survival of 27 mo when treated with erlotinib. However, EGFR mutations can only imperfectly predict outcome. In NSCLC cell lines, tyrosine kinase inhibitors (TKIs) induce p53 translocation from the cytoplasm to the nucleus and subsequent up-regulation of Fas and caspase activation leading to apoptosis. This mechanism was defective in p53-null cells. We tested whether mutations in the TP53 gene influence outcome to erlotinib in EGFR-mutated patients (p). Expression levels of the p53 repressor MDM2 were also examined. Methods: We assesed p53 status in pretreatment paraffin-embedded tumor samples from 93 erlotinib-treated, EGFR mutated advanced NSCLC p. Mutations in exons 5, 6, 7 and 8 were screened by High Resolution Melting analysis (HRM) followed by sequencing of the amplified products with non-wild type melt curves. All mutant samples were re-confirmed by standard PCR and sequencing. Expression levels of MDM2 mRNA were determined by quantitative RT-PCR. Results: Mutations in exons 5-8 of the TP53 gene were detected in 26 of 93 p (28%). We found an unusually high frequency of in-frame and frameshift deletions (23% of mutations), indicating that the spectrum of p53 mutations might be different in EGFR-mutated NSCLC. Mutations in the TP53 gene were not associated with sex, age, smoking status, histology, exon 19 vs. 21 mutation, or response, but, within the study population, were significantly less frequent in p with ECOG 2 or above. The mutations were also associated with the presence of the pretreatment T790M mutation. 14 p had mutations in one of the p53 DNA binding motifs (DBMs), and showed TTP to erlotinib of only 9 mo, compared to 19 months for wt p and 27 mo for those carrying a non-DBM mutation. Survival was 24 mo vs. 31 mo, and not-reached, respectively. Finally, MDM2 mRNA levels were significantly lower in tumors with p53 mutations, especially when these affected DBMs. In the case of wt p, high MDM2 expression correlated with a better TTP and survival. Conclusions: TP53 mutations co-exist with EGFR mutations in a significant number of p; and those in the DBMs are associated with poorer response to erlotinib. This finding paves the way for the possibility of combining erlotinib with a drug restoring p53 function in those p harboring DBM mutations in the TP53 gene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4596. doi:1538-7445.AM2012-4596

Topic: Lung Cancer Treatments and Mutations
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Enablers, Barriers and Practical Applications of a Group‐Based Pain Self‐Management Program for Patients Receiving Medical Cannabis: A Qualitative Study of Patients and Clinicians

ABSTRACT Background Pain self‐management (PSM) programs have demonstrated effectiveness as a pain management strategy, yet evidence remains scarce for patients with chronic pain treated with medical cannabis. We aimed to explore feasibility aspects and practical applications of developing and implementing a group‐based PSM intervention in this context. Methods Twenty‐two semi‐structured qualitative interviews were conducted with 10 chronic pain patients treated with cannabis and 12 clinicians from a range of expertise. Results Overall, the interviewees believed that the proposed intervention is feasible; yet it is essential to consider the following aspects during program planning and implementation. Inductive thematic analysis of interview transcripts identified five major themes. The first is that the program enablers include the intrinsic benefits of therapeutic group dynamics, aligning expectations, and setting individual goals at program initiation. The second theme is the program barriers. These include expected challenges for participants due to behavioral and mental changes that necessitate high commitment, the challenge for the group leader in delivering an appropriate response to each participant's emotional narrative; and managing logistical issues. The third theme is the psychological experience of living with pain, with an emphasis on addressing patients' emotional perspectives within the program's framework, namely, their perceptions of pain, fear of pain, and the relations of such to past experiences. The fourth theme is the psychoeducation on pain and cannabis use, including the brain‐pain connection and informed guidance regarding cannabis use. The fifth theme is the integration of guided movement and relaxation techniques in pain management, thus underscoring the importance of practice during the group sessions. Conclusions Our findings suggest key elements that may inform planning PSM‐approach therapy groups, tailored to the particular needs of patients with chronic pain using medical cannabis.

Topic: Cannabis and Cannabinoid Research
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Generalized Convex Functions and Their Applications

This study focuses on convex functions and their generalized. Thus, we start this study by giving the definition of convex functions and some of their properties and discussing a simple geometric property. Then we generalize E-convex functions and establish some their properties. Moreover, we give generalized $ s $-convex functions in the second sense and present some new inequalities of generalized Hermite-Hadamard type for the class of functions whose second local fractional derivatives of order $ α$ in absolute value at certain powers are generalized $ s $-convex functions in the second sense. At the end, some examples that these inequalities are able to be applied to some special means are showed.

Topic: Mathematical Inequalities and Applications
Subfield: Applied Mathematics
Field: Mathematics
Domain: Physical Sciences