jimnoneill/paper-to-field-training huggingface dataset:
RF AND SRF COMPONENTS FOR BERLINPRO

The Energy Recovery Linac ERL project BERLinPro is funded as of January 2011 and is now in the design phase. BERLinPro should demonstrate the feasibility to use ERL technology for high current low emittance applications, The planned SRF layout is described including the RF transmitter, the couplers and the configuration of the SRF modules. The project has been reviewed by a machine advisory committee MAC

Topic: Phytochemistry and biological activity of medicinal plants
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Anti-Inflammatory Effects of Aspalathus linearis and Cyclopia spp. Extracts in a UVB/Keratinocyte (HaCaT) Model Utilising Interleukin-1α Accumulation as Biomarker

Ultraviolet B (UVB) radiation is one of the major predisposing risk factors of skin cancer. The anticancer and photoprotective effects of unoxidized rooibos (Aspalathus linearis) and honeybush (Cyclopia) herbal teas, containing high levels of dihydrochalones and xanthones, respectively, have been demonstrated in skin cancer models in vivo. In the current study, the anti-inflammatory effects of methanol and aqueous extracts of these herbal teas were investigated in a UVB/HaCaT keratinocyte model with intracellular interleukin-1α (icIL-1α) accumulation as a biomarker. Extracts of green tea (Camellia sinensis) served as benchmark. Both extracts of green tea and rooibos, as well as the aqueous extract of C. intermedia, enhanced UVB-induced inhibition of cell viability, proliferation and induction of apoptosis, facilitating the removal of icIL-1α. The underlying mechanisms may involve mitochondrial dysfunction exhibiting pro-oxidant responses via polyphenol-iron interactions. The methanol extracts of honeybush, however, protected against UVB-induced reduction of cell growth parameters, presumably via antioxidant mechanisms that prevented the removal of highly inflamed icIL-1α-containing keratinocytes via apoptosis. The dual antioxidant and/or pro-oxidant role of the polyphenolic herbal tea constituents should be considered in developing preventive strategies against UVB-induced skin carcinogenesis. The indirect removal of UVB damaged keratinocytes by herbal tea extracts via apoptosis may find application in the prevention of photo-induced inflammation.

Topic: Tea Polyphenols and Effects
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Propagation d'impulsion laser ultracourtes dans un cristal non linéaire

In this paper, we present a mathematical model for ultrashort pulses propagation in nonlinear optical crystals. For ultrashort pulses, classical models based on the slowly varying envelope approximation are no longer relevant. The microscopic model based on the Maxwell-Bloch model, that we present, can accurately describe the wave-propagation while accounting for dispersive nonlinearities. We will describe this model and its numerical discretization in two dimensions of space. Finally, we perform two numerical experiments.

Topic: Laser-Matter Interactions and Applications
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Clinical Evidence for Critical Cardiac Care

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal

Topic: Heart Failure Treatment and Management
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Traction Model Development.

Abstract : This report provides the theoretical background, the numerical procedures and a comparison with test results for a PC-based computer program for computing traction force components and torque in an elastohydrodynamically lubricated contact. The program provides a comprehensive tribological assessment of a general lubricated, concentrated contact under combined rolling, spinning and sliding. The joint effect of 34 input variables can be considered in the descriptive characteristics of the contact. Keywords: Traction, Modelling, Traction model.

Topic: Gear and Bearing Dynamics Analysis
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Evangelical Anglicans in a revolutionary age, 1789–1901. By Nigel Scotland. Pp. xiii+457. Carlisle: Paternoster, 2004. £19.99 (paper). 1 84227 231 4

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.

Topic: Religion, Society, and Development
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Isolation and Characterization of New Bacillus thuringiensis Strains with Insecticidal Activity to Difficult to Control Lepidopteran Pests

Strains were isolated from soil samples collected from mountains and fields of Yeong–Dong and Ok–cheon, ChungBuk province in order to select B. thuringiensis strains with high insecticidal activities against lepidopteran pests. Eight B. thuringiensis strains producing spores and endotoxin proteins were selected from a total of 26 soil samples. Tests of biological activities in Spodoptera litura, Spodoptera exigua, Plutella xylostella, and Aedes aegypti were performed with 8 isolates of B. thuringiensis. CAB565 and CAB566 strains were selected, because such strains showed more than 80% of insecticidal activities against four kinds of pests. Selected two strains formed endotoxin proteins in a typical bipyramidal type. CAB565 and CAB566 strains were identified as thuringiensis subsp. kurstaki, and thuringiensis subsp. aizawai, respectively. LC_&lt;50&gt; value of CAB566 strain against larvae of S. litura at the fourth stage was 7.7×10^5 (cfu/ml), which was the highest activity. LC_&lt;50&gt; value of CAB565 strain against larvae of S. exigua at the fifth stage was 3.0×10^6 (cfu/ml), which was high activity. Through SDS–PAGE, CAB565 and CAB566 strains showed a band at 130 kDa. After it reacted with midgut juice of S. litura and S. exigua, a band of toxin protein was shown at 65 kDa. According to results of PCR analysis, it was found that cry1Aa, cry1Ac and cry1I genes were present in CAB565 strain and it was different from B. thuringiensis subsp. kurstaki. cry1Aa, cry1C, cry1D and cry1I genes were present in CAB566 strain and it was different from B. thuringiensis subsp. aizawai. As a result of plasmid DNA patterns, B. thuringiensis subsp. kurstaki KB099 strain and CAB565 strain had 5 and 10 plasmid DNAs, respectively. B. thuringiensis subsp. aizawai KB098 strain and CAB566 strain had 9 and 7 plasmid DNAs, respectively.

Topic: Insect Resistance and Genetics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Biodistribution of a polyethylene glycol-modified superoxide dismutase in mice and its effect on myocardial ischemia treatment in rats

We have performed a comparative study of the biodistribution in mice of native and monomethoxypolyethylene glycol-modified superoxide dismutase isolated from bovine liver after intravenous injection. Polymer modification greatly influenced the biodistribution of enzyme preparation. Monomethoxypolyethylene glycol-modified SOD (mPEG-SOD) exhibited a longer residence time and a considerably longer half-time in the blood, lungs, and heart than the native enzyme. Using a rat model of ischemia, we demonstrated that an intravenous bolus administration of mPEG-SOD reduced the size of the myocardium necrosis zone by 40% compared with a 13% reduction by native enzyme. These results suggest that mPEG-SOD is a promising agent for decreasing reperfusion injury to the cardiovascular system.

Topic: Cardiac Ischemia and Reperfusion
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
A Conceptual Framework to Program Risk Management Bruno Rafael Dias de Lucena

The benefits associated with program risk management are related to increasing the program capability to meet its strategic objectives. Despite the popularity of risk management in projects, the discussion on program risk management is quite recent. Some initiatives have emerged to adjust the project risk management concepts and techniques for use in programs, but the dissimilarities in their natures and goals make them unsatisfactory. This paper proposes a conceptual framework for understanding the risk management process in programs and deploying it without losing the strategic perspective. Contrasting with the existing published guidelines for program risk management, the framework presented emphasizes the strategic and dynamic character of program management thus exposing important aspects of program risk management often neglected, among them: (a) because program management subject matter changes with the program lifecycle phase, and with revisions of strategic objectives, risk management must be well integrated into program management structure and processes;(b) in planning risk management it must be recognized that the risk identification process also varies according to the phase of the program, having different objectives, involving different people, and requiring different analyses and treatment; (c) program risks may arise at different levels of management and it is up to the program management to recognize what risks it must manage, which ones it may just monitor, and which ones it must delegate completely to the project management level; (d) for the same token, program management must be able bring to the attention of top management risks of strategic importance that are not visible to them (i.e. originated in the program or project realm). Though the focus of the paper is on the program management as a special organizational device, the framework extends to different levels of management. The program characteristics necessary to make this approach applicable are discussed.

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Effects of sterol structure on insect herbivore physiology, biochemistry and molecular biology

Sterols serve two important biological functions in animals - they act as cellular membrane components, and as the precursor to steroid hormones. Insects require a dietary source of sterol because they cannot synthesize sterols de novo. Cholesterol is the most common sterol in plant-feeding insects, but because plants contain very little cholesterol, plant-feeding insects must convert plant sterols into cholesterol. In this dissertation I investigate the effect of common and novel plant sterols and steroids found in a transgenic tobacco line on several caterpillar species. I also explore the metabolism of these sterols and steroids, and use a microarray approach to identify genes involved in sterol use and metabolism in plant-feeding insects. I also study cholesterol homeostasis using a grasshopper species.\n\nModified tobacco plants containing a novel sterol profile negatively affected performance three different caterpillar species, especially in the second generation. Insects reared on modified plants contained less total sterols and cholesterol than those on control plants having normal sterol profile. Similar results were found using artificial diets containing atypical steroids, e.g., cholestanol and cholestan-3-one, identified in the tobacco plants that were fed to my experimental caterpillars. More importantly, the sterol/steroid ratio, but not their absolute amount in the diets, determined the negative effects.\n\nCaterpillar species could convert stigmasterol, a common plant sterol, into cholesterol. They could also convert cholestan-3-one into cholestanol and epicholestanol, although this ability varied among different species. A microarray study, that focused on gene expression in midgut tissue, indicated that stigmasterol, cholestanol and cholestan-3-one could induce different gene expression level, and that cholestan-3-one caused a the largest pool of genes to be regulated. The genes possibly involved in the metabolism of stigmasterol and cholestan-3-one were reported. These findings are important in directing further research on the potential application of plant sterol modification to control pests in agricultural systems.\n\nInsect herbivores could behaviorally regulate the intake of several nutrients, but they could not regulate their sterol intake. They did, however, practice cholesterol homeostasis, by postingestively regulating tissue sterol levels, even when feeding on diets with high cholesterol content. Collectively, the results from this dissertation provide unique insight into cholesterol regulation, which is difficult to achieve in mammals that are capable of synthesizing their own sterols.

Topic: Insect-Plant Interactions and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[Psychological and neurologic long-term consequences of brain tumors in children. A pilot study].

Brain tumor is one of the most common forms of cancer in children. The therapy includes surgical interventions, radiation of the central nervous system and chemotherapy. Combining these methods of treatment has remarkably improved the survival of children with certain brain tumours (e.g. medulloblastoma). However, long-term studies have revealed serious psychological and somatic consequences of the disease and the treatment. This paper presents the results of a pilot study of nine children with brain tumor. The patients were examined using a battery of neuropsychological methods (Luria's Neuropsychological Investigation, WISC-R), a semi-structured interview (Child Assessment Schedule), a parent report form (Achenbach Child Behaviour Checklist) and a clinical neurological examination. The most striking finding from this investigation was in the psychosocial field. Except for one child, all the patients showed an introvert reaction pattern with a tendency towards anxiety, depression and social withdrawal. All the children showed some neurological and neuropsychological deficits. Except in the case of two mentally retarded children, cognitive functions were within the lower normal range. Specific learning, memory and fine-motor disabilities were found in more than half of the patients. The investigation suggested that both fine-motor and mental performance was detrimentally affected by increased speed. This seems to be an area of special interest for further studies.

Topic: Childhood Cancer Survivors' Quality of Life
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Intergenerational Ambivalence from Adolescence to Young Adulthood: Implications for Well-being

The parent-child relationship is often characterized by ambivalence, defined as the simultaneous experience of positive and negative relationship quality. This study examines reports of intergenerational ambivalence among adolescents, emerging adults, and young adults and the implications of ambivalence for well-being over a 12 year period. Participants ranging in age from 13 to 29 completed surveys in 1992 and again in 2005. Results indicate that overall, offspring’s feelings of ambivalence decreased over time (between Wave 1 and Wave 2). Ambivalence towards mothers and fathers predicted greater depressive symptoms over time. These results suggest that later well-being is vulnerable to the quality of the parent-child relationship in early life.

Topic: Intergenerational Family Dynamics and Caregiving
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
[Sequence of events in the process of factor-promoted translocation in the ribosome].

A system of translation of matrix-bound poly(U) by purified Escherichia coli ribosomes was used to obtain pre-translocation state ribosomes in columns and then to induce translocation under controlled conditions by passing the elongation factor G (EF-G) with the non-cleavable GTP analog (guanylyl-methylene diphosphonate). It has been shown that translocation in the ribosome, checked by the release of deacylated tRNA, as well as by the puromycin reaction, is induced by the attachment of EF-G (with the non-cleavable GTP analog) to the ribosome and not by its detachment. In accordance with this, the ionic conditions under which the affinity of EF-G with the GTP analog to the ribosome is increased (NH4Cl instead of KCl, a lowered ionic strength) have been also found to be more effective for translocation. On the other hand, it has been shown that the detachment (removal) of EF-G is a strict pre-requisite for the appearance of competence to bind the next aminoacyl-tRNA, and thus for a continuation of the elongation cycle. A conclusion is made that the mechanical shifts of products and substrates, such as peptidyl-tRNA and deacylated tRNA, within the ribosome in the process of translocation are promoted only by the affinity of EF-G to the ribosome and does not depend on the cleavage of GTP. On the basis of the results obtained, the following sequence of events is deduced for the process of EF-G-promoted translocation: 1) interaction of EF-G.GTP with the pre-translocative ribosome, 2) translocation displacements of products and substrates, including the release of deacylated tRNA (probably conjugated with the shift of mRNA), 3) GTP hydrolysis, 4) release of EF-G and GTP from the post-translocated ribosome.

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Correction of aberrant imprinting by allele‐specific epigenome editing

Imprinting disorders are caused by the loss of the normal allele‐specific DNA methylation at imprinting centers. Epigenetic editing is a promising approach to alter DNA methylation at defined genomic target regions. The novel development of CRISPR‐Cas9‐based DNA binding domains may allow for an allele‐specific editing of DNA methylation at imprinted loci, for the first time offering a rational approach for correction of the molecular defects in imprinting disorders.

Topic: CRISPR and Genetic Engineering
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
First isolation of enteric adenoviruses type 41 from children with acute gastroenteritis in Hungary.

In a retrospective study, 122 stool specimens, collected 1989-1990, from children with gastroenteritis were found to contain adenoviruses. Twenty-nine adenoviruses of 50 randomly selected adenovirus-positive fecal samples were successfully propagated in Graham 293 cells and were typed by DNA restriction enzyme analysis with SmaI. Six strains were typed as adenovirus 41 (Ad41), and 23 strains as non-enteric adenovirus. All six adenoviruses type 41 had the same DNA pattern identical with that of the variant Ad41/D12. Ad40 viruses were not detected. Enteric Ad41 infections were observed only in males and were found throughout the year. This is the first report on isolation and typing of enteric adenoviruses 41 in Hungary.

Topic: Viral gastroenteritis research and epidemiology
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Extraordinary circumstances: Covid-19 – Italian Serie A scenario

Unpredictable and uncontrollable situations have happened throughout history. Inevitably, such situations have an impact on various spheres of life. The coronavirus disease 2019 has affected many of them, including sports. The ban on social gatherings has caused the cancellation of many sports competitions. This paper proposes a methodology based on hierarchical cluster analysis (HCA) that can be applied when a need occurs to end an interrupted tournament and the conditions for playing the remaining matches are far from ideal. The proposed methodology is based on how to conclude the season for Serie A, a top-division football league in Italy. The analysis showed that it is reasonable to play 14 instead of the 124 remaining matches of the 2019–2020 season to conclude the championship. The proposed methodology was tested on the past 10 seasons of the Serie A, and its effectiveness was confirmed. This novel approach can be used in any other sport where round-robin tournaments exist.

Topic: Sports Analytics and Performance
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Magnetic resonance imaging parameters in predicting the ablative efficiency of high-intensity focused ultrasound for uterine fibroids

The signal intensity ratio of fibroid to skeletal muscle on T2WI can be used as a factor for predicting the effectiveness of HIFU ablation of uterine fibroids.

Topic: Uterine Myomas and Treatments
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Fluorescent label improves assay speed and sensitivity

A new ultrabright fluorescent label might make bioassays faster and more sensitive. Srikanth Singamaneni and coworkers at Washington University in St. Louis make their "plasmonic-fluor" labels of a bovine serum albumin scaffold attached to approximately 210 copies of a near-infrared-active fluorophore, a biotin biorecognition group, and a polymer-coated gold nanorod (Nat. Biomed. Eng. 2020, DOI: 10.1038/s41551-020-0547-4). The nanorod boosts fluorescence intensity, resulting in a label that is about 6,700 times as bright as an individual fluorophore. The biotin recognition element enables binding to streptavidin, which is commonly used in various types of bioassays. In this way, the plasmonic-fluor can be incorporated as a final step in otherwise normal assay protocols. The researchers used the new label in a variety of bioassays, including immunomicroarrays, flow cytometry, and immunocytochemistry. By using the label, the researchers detected analytes in fluorescence-linked immunosorbent assays (FLISA) at about 20 fg/mL, compared with 95 pg/mL for conventional

Topic: Pharmaceutical studies and practices
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Writing Successful Covering Letters for Unsolicited Submissions to Academic Journals

Writing a covering letter is a necessary step before submitting an unsolicited manuscript to an academic journal. In cases where the author has not queried the editor of the target journal prior to submission, the covering letter can - and should - be drafted to serve three functions. This article demonstrates how a covering letter can (1) establish the author's credibility, (2) help ensure that the manuscript is seriously considered for publication, and (3) initiate a positive rapport with the editor and editorial staff of the journal. In addition, this article includes sample texts from ‘successful’ covering letters: covering letters that, ultimately, result in having the accompanying manuscript accepted for publication.

Topic: Academic Writing and Publishing
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences