jimnoneill/paper-to-field-training huggingface dataset:
A molecular docking insight: Phyllanthus niruri L. constituents targeting MMP-9 for angiogenesis inhibition and IL-1beta for antiinflammatory action in endometriosis therapy

Endometriosis, characterized by inflammatory lesions resembling endometrium outside the uterine cavity, induces chronic inflammation, anatomical changes and persistent pain. The expression of Interleukin 1beta (IL-1beta) is significantly associated with endometriosis, contributing to inflammatory process and fertility issues. Matrix metalloproteinase 9 (MMP-9) is crucial in the adhesion and angiogenesis of endometrial tissue. This study investigates the potential of Phyllanthus niruri L. in inhibiting MMP-9 and IL-1beta through molecular docking analysis. Molecular docking was performed using Discovery Studio Visualizer, Open Babel, PyRx and AutoDock Vina. The inhibitory activities of bioactive compounds on MMP-9 and IL-1beta were predicted. Biological activity and cytotoxicity were assessed using PASS and CLC-Pred respectively. Kaempferol and quercetin from P. niruri exhibited significant MMP-9 expression inhibitory activity. Search Tool for Interacting Chemicals (STITCH) analysis revealed interactions of quercetin and galangin with specific proteins involved in pathways related to endometriosis. Biological activity analysis indicated that quercetin, kaempferol, herbacetin and galangin show potential as MMP -9 expression inhibitors. CLC-Pred analysis suggested high cytotoxicity of kaempferol against glioma. Molecular docking results showed quercetin's potential as an MMP-9 inhibitor and galangin's potential as an IL-1 beta inhibitor. These findings support the therapeutic potential of P. niruri for endometriosis, providing insights for further research in developing innovative therapies targeting endometriosis-related inflammation and angiogenesis.

Topic: Phytochemistry and Bioactivity Studies
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Changing Epidemiological and Clinical Aspects of Imported Malaria in Belgium

The incidence of subacute malaria dropped significantly in the last decade. Although this presentation is almost limited to residents, the decline in malaria can not be explained by an overall shorter duration of stay, since the decline in this particular clinical presentation of malaria was also spectacular in residents. Apparently, insufficient treatment of malaria attacks in the previous months is the only independent risk factor.

Topic: Malaria Research and Control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Abstract 149: Differences In Self-reported Health Status Among Underrepresented Populations In Stroke Survivors Enrolled In <i>All Of Us</i>

Background: Self-reported outcomes in stroke survivors remain understudied. Mounting evidence indicate that the burden of stroke is disproportionately high in underrepresented groups. We investigated differences in self-perceived health status in stroke survivors across broadly defined underrepresented minorities. Methods: We analyzed data from stroke survivors enrolled in All of Us. Ischemic and hemorrhagic stroke were defined using validated ICD10 codes. Self-perceived health status was evaluated using 5 domains (quality of life, physical health, mental health, social activities and overall health), each with 5 answers (excellent, very good, good, fair and poor). Each domain was dichotomized as favorable (excellent, very good or good) or unfavorable (fair/poor). We used multivariate logistic regression to model the odds of favorable self-perceived health status in underrepresented groups defined by race/ethnicity, education, income and insurance type. Results: 6,977 stroke survivors were included (mean age 64, female sex 58%), including 1,623 (23.3%) Blacks, 856 (12.3%) Hispanics/Latinos, 654 (9.4%) with less than a high school degree, 2,679 (38.4%) with income &lt;U$S 35k, 3,091 (44.3%) with Medicare/Medicaid and 13 (0.18%) uninsured. A number of underrepresented groups had significantly different self-perceived health status after stroke (Table): low income, limited education and Medicare/Medicaid insurance were associated with self-perceived unfavorable health status in all 5 domains (all results with 95%CI &lt;1). Conclusion: Among stroke survivors, underrepresented groups defined by income, education and health insurance were more likely to perceive their health status as unfavorable. Evaluation of underrepresented groups defined by factors other than race/ethnicity was important to identify these differences. Further research should evaluate whether these differences correlate with objectively measured outcome measures.

Topic: Cardiovascular Health and Risk Factors
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
AN INCIDENT OF BILATERAL MASTODYNIA AFTER THE MENOPAUSE

Abstract. A 54‐year‐old postmenopausal woman is described who quite suddenly experienced intense tenderness and tension in both breasts lasting for about 3 weeks. Subsequently she had a uterine bleeding. Excessively increased levels of estradiol (peak value 2 325 pmol/1) were found during the period of mastodynia. Seven months previous to this event, hyperthyroidism had been diagnosed. She had, however, been treated with porpylthiouracil and was euthyroid long before and during the period of mastodynia.

Topic: Biotin and Related Studies
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Storying and Recovering the Self: A Journey Towards Transformation in Men in Addictions and Trauma Recovery

This paper examines the stories of transformative learning of two men reflecting on their recovery from addictions and trauma. We employ the Hero’s journey as a useful frame within which to understand their stories of becoming more and progressing towards a recovered self. The article challenges the dominant biomedical model of addiction, and of recovery as being primarily about abstinence. It also provides further evidence for understanding transformative learning as a process of (re)integration which is supported through archetypal storytelling.

Topic: Optimism, Hope, and Well-being
Subfield: Applied Psychology
Field: Psychology
Domain: Social Sciences
[A case of recurrent gastrointestinal stromal tumor with complete response from treatment with reduced dose of imatinib mesylate].

We report a patient who had a complete response by treatment with 200 mg of imatinib mesylate daily for peritoneal recurrences of gastrointestinal stromal tumor(GIST)of the stomach. On March 2007, a 68-year-old woman underwent distal gastrectomy for GIST of the stomach. On May 2007, peritoneal recurrences were recognized on CT scan, and treatment with 400 mg daily of imatinib mesylate was started. Because grade 2 systemic edema and rash developed one week later, the imatinib mesylate dose had to be reduced to 200 mg daily from July 2007. After reduction of imatinib mesylate, the adverse reactions resolved. Peritoneal dissemination disappeared on CT scan from April 2010, and complete response has been maintained for 18 months.

Topic: Gastrointestinal Tumor Research and Treatment
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Non-Destructive In-Process Quality Evaluation Of Plant-Sourced Food During Drying

Abstract Plant-sourced food has a crucial role in the human food supply as the source of calories and many valuable micronutrient compounds that enhance a balanced and healthy lifestyle. However, a portion of food intended for human consumption produced globally become wastage per year because of a lack of proper processing and preservation technologies. Drying is one of the broadly utilised preservation technologies in plant-sourced food. Most drying studies focused on post-process evaluation on product quality; meanwhile, monitoring and controlling amid the drying process (in-process) is essential because these activities can improve the drying condition and optimise the end product’s quality. Furthermore, the non-destructive inspection method is essential in developing smart food processing units and can be more efficient, rapid, reduced sample waste, and environmentally friendly than traditional inspection methods. The authors also discuss the overview of quality parameters investigated during plant-sourced food drying with in-process and non-destructive quality evaluation techniques. Finally, the authors also discuss the prospects and challenges of the real-time and non-destructive quality evaluation application.

Topic: Food Drying and Modeling
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Tierney, B., Origins of Papal Infallibility 1150—1350. A Study on the concepts of Infallibility, Sovereignty and Tradition in the middle ages. Leiden: E. J. Brill 1972. X, 298 p. = Studies in the History of Christian Thought VI.

"Tierney, B., Origins of Papal Infallibility 1150—1350. A Study on the concepts of Infallibility, Sovereignty and Tradition in the middle ages. Leiden: E. J. Brill 1972. X, 298 p. = Studies in the History of Christian Thought VI." published on 24 Nov 1974 by Brill | Schöningh.

Topic: Theology and Canon Law Studies
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Analysis of the crystal oscillators phase noises and methods of their reduction

The article determines main components of the communication devices phase noises and observes methods of measurement and assessment of main components of quartz oscillators phase noises. A practical study of the parameters of crystal oscillators and the means of optimizing of the phase noises introduced by them was conducted. The article introduces a method for reducing the noises with thermostat structural means, in order to increase thermodynamic stability of the quartz resonator. Factors affecting the level of noises are observed, depending on the manufacturing technology of the quartz resonator. According to the results of the experimental data the article provides recommendations for their reduction.

Topic: Advanced Scientific Research Methods
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Long-Term Influences on Demented Patients in Different Caring Milieus, a Collective Living Unit and a Nursing Home: A Descriptive Study

Environmental influences on demented patients in a collective living (CL group, n = 5) and a nursing home (NH group, n = 5) were studied during 22 months. Intellectual functions rated by the GBS scale indicated a smaller deterioration in the CL group (p &amp;#60; 0.05). A quotient was constructed of EEG alpha/delta activities, which ratio had increased in the CL group, indicating a reduction of dementia-induced changes, and was reduced in the NH group (p &amp;#60; 0.05). The CL group showed signs of better social abilities, more alertness, reduced signs of depression, but caused more 'disturbances'. It seemed, however, as if these patients' behaviour were better accepted by the staff.

Topic: Geriatric Care and Nursing Homes
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Die Staublungenerkrankungen

REVIEWSderivates have been given with good results.Under a recent Italian law all workers using vibrating tools are required to undergo an annual medical examination.In some ways Italian law seems ahead of that of other countries, particularly in the recognition and introduction of regulations to limit new hazards.Thus beryllium was early recognized as a highly toxic material and those working with it appear to be adequately safeguarded.This is also the case with the industrial use of fluorides.This book is attractively produced and contains many useful illustrations and figures.

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Web 2.0 and Opportunities for Entrepreneurs

The increasing value of Web 2.0 applications and their effects on consumers and organizations are frequently attracting academic and professional communities. A new set of new technologies, called Web 2.0, offers new opportunities, and blurs the boundaries between online and offline activities, opening a new era characterized by: openness, collaboration, and participation. It presents a new affordable channel for entrepreneurs in different sectors to market and build communities, and to receive a direct feedback about their products and services. Even though entrepreneurship in general and their use of Web 2.0 in particular are relatively new concepts especially in developing countries, entrepreneurship has gained a special interest in Egypt due to the success realized by some youth entrepreneurs who consider the Internet and different Web 2.0 applications as an integral aspect in their daily lives. Hence, the present chapter investigates opportunities for small businesses in the Web 2.0 era. In-depth semi-structured interviews were arranged with a number of Egyptian entrepreneurs who started their business. The research conducted revealed that Web 2.0 adoption by Egyptian entrepreneurs is affected by three main factors: age of entrepreneur, date of establishment of the company, and nature of the business: traditional or virtual. It was concluded also that Egyptian entrepreneurs are still at an early stage in using Web 2.0 since a large number of the sample used in this research are still reluctant to consider incorporating this technology in their working practice. For those already embracing Web 2.0, they limit such use on social media only without considering other applications (such as podcasts, really simple syndication, blogs, wikis, etc.), and they do not have clear objectives and strategies that govern such use. Findings of this study can provide helpful guidelines for small businesses to begin using and leveraging Web 2.0. This chapter provides a valuable contribution to the field of entrepreneurship and electronic business research. Specifically, the chapter highlights the applicability of Web 2.0 in entrepreneurial activities in developing countries: an area of research yet unexplored.

Topic: Digital Marketing and Social Media
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Clinical characteristics of newborn with different birth weight (results of a multicenter cohort study)

This article is dedicated to analysis of clinical characteristics of children with different birth weight included in the multicenter cohort study of newborns. The study analyzed data 572 children who were stratified according to birth weight (normal, low, very low and extremely low body weight). As part of the protocol incorporating the patient’s visit was provided at the time of birth (visit 0), a retrospective collection of anamnestic data about the mother (Visit -1) and visit prospective study of children aged 12 months (Visit 1). As a result of the analysis, it was found that the increase in frequency of operative delivery, and reduction of Apgar score and the presence of the studied pathological conditions, to the greatest extent, common in children who had birth weight of less than 1500 in this case. The probability of a combination of 3 or more conditions (described in this paper), in the case of a child with an extremely low birth weight was higher in the 44-fold (OR = 44.52; CI95% 15,5-127,5), while when the newborn had very low birth weight - a chance of development was significantly higher only in the 7-fold (OR = 7.12; CI95% 2,4-20,9) compared with children who had a low birth weight. In this regard, there is a need not only to the use of modern technologies nursing of low birth weight infants, but also provide preventive care in a group of women with a high degree of perinatal risk and risk of preterm delivery, allowing prolong pregnancy up to 32 weeks and/or weight of the fruit body of more than 1000 g, which can improve the survival rates of patients and the prevention of premature severe disabling conditions in the future.

Topic: Child and Adolescent Health
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Alpha-1-antitrypsin deficiency: increasing awareness and improving diagnosis

Alpha-1-antitrypsin deficiency (AATD) is a hereditary disorder that is characterized by a low serum level of alpha-1-antitrypsin (AAT). The loss of anti-inflammatory and antiproteolytic functions, together with pro-inflammatory effects of polymerized AAT contribute to protein degradation and increased inflammation resulting in an increased risk of developing chronic obstructive pulmonary disease (COPD) and emphysema, especially in smokers. AATD is a rare disease that is significantly underdiagnosed. According to recent data that are based on extrapolations, in many countries only 5–15% of homozygous individuals have been identified. Furthermore, the diagnostic delay typically exceeds 5 years, resulting in an average age at diagnosis of about 45 years. Although the American Thoracic Society/European Respiratory Society recommendations state that all symptomatic adults with persistent airway obstruction should be screened, these recommendations are not being followed. Potential reasons for that include missing knowledge about the disease and the appropriate tests, and the low awareness of physicians with regard to the disorder. Once the decision to initiate testing has been made, a screening test (AAT serum level or other) should be performed. Further diagnostic evaluation is based on the following techniques: polymerase chain reaction (PCR) for frequent and clinically important mutations, isoelectric focusing (IEF) with or without immunoblotting, and sequencing of the gene locus coding for AAT. Various diagnostic algorithms have been published for AATD detection (severe deficiency or carrier status). Modern laboratory approaches like the use of serum separator cards, a lateral flow assay to detect the Z-protein, and a broader availability of next-generation sequencing are recent advances, likely to alter existing algorithms.

Topic: Protease and Inhibitor Mechanisms
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Hisashi Nasu, Lester Embree, George Psathas, and Ilja Srubar (eds.), Alfred Schutz and His Intellectual Partners; Sandra P. Thomas and Howard R. Pollio, Listening to Patients, A Phenomenological Approach to Nursing Research and Practice; Matthew Ratcliffe, Rethinking Commonsense Psychology: A Critique of Folk Psychology, Theory of Mind and Simulation

Hisashi Nasu, Lester Embree, George Psathas, and Ilja Srubar (eds.), Alfred Schutz and His Intellectual Partners; Sandra P. Thomas and Howard R. Pollio, Listening to Patients, A Phenomenological Approach to Nursing Research and Practice; Matthew Ratcliffe, Rethinking Commonsense Psychology: A Critique of Folk Psychology, Theory of Mind and Simulation

Topic: History of Science and Medicine
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences
A New Route to Diaminoacetylenes

Inspired by the preparation of diaryl-acetylenes, a general synthetic approach to diaminoacetylenes (ynediamines) has been developed based on the Fritsch-Buttenberg-Wiechell rearrangement. Both aromatic and aliphatic diaminoacetylenes 5 can be synthesized conveniently in moderate to high yields. X-ray crystal structures of the diaminoacetylenes (5a and 5b) have been determined for the first time, confirming the theoretical prediction that the two NC3 planes are almost perpendicular.

Topic: Ferrocene Chemistry and Applications
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
ORTHOTOPIC PARTIAL LIVER TRANSPLANTATION IN THE RAT

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Topic: Organ Transplantation Techniques and Outcomes
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Refractive Index Formulae for Radio Waves

The radio refractive index formula adopted in 1963 by the International Union of Geodesy and Geophysics (IUGG) and the International Association of Geodesy (IAG) is being reviewed. Forty years ago, this formula was essential for the reduction of distances measured with microwave EDM instruments. Since then, long-range EDM has been replaced by the Global Positioning System (GPS). Today, the formulae are important for accurate measurements using radio waves, including GPS and VLBI (Very Long Baseline Interferometry). The new radio wave refractive index formulae of the last decades are discussed and the inherent problems of some of them are pointed out. State-of-the art formulae for routine and precise measurements in the radio wave spectrum are discussed as are computer programs that model the influences of resonance lines. Two formulae for hand calculations of the radio refractive index Nr (in ppm, for infinite wavelengths) have been designed, one based on 'best available' coefficients and one based on 'best average' coefficients. For air with 0.0375% (375 ppm) content of CO2, the latter is:

Topic: GNSS positioning and interference
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences