jimnoneill/paper-to-field-training huggingface dataset:
Identification of SNPs Associated with Somatic Cell Score in Candidate Genes in Italian Holstein Friesian Bulls

Mastitis is an infectious disease affecting the mammary gland, leading to inflammatory reactions and to heavy economic losses due to milk production decrease. One possible way to tackle the antimicrobial resistance issue stemming from antimicrobial therapy is to select animals with a genetic resistance to this disease. Therefore, aim of this study was to analyze the genetic variability of the SNPs found in candidate genes related to mastitis resistance in Holstein Friesian bulls. Target regions were amplified, sequenced by Next-Generation Sequencing technology on the Illumina® MiSeq, and then analyzed to find correlation with mastitis related phenotypes in 95 Italian Holstein bulls chosen with the aid of a selective genotyping approach. On a total of 557 detected mutations, 61 showed different genotype distribution in the tails of the deregressed EBVs for SCS and 15 were identified as significantly associated with the phenotype using two different approaches. The significant SNPs were identified in intergenic or intronic regions of six genes, known to be key components in the immune system (namely CXCR1, DCK, NOD2, MBL2, MBL1 and M-SAA3.2). These SNPs could be considered as candidates for a future genetic selection for mastitis resistance, although further studies are required to assess their presence in other dairy cattle breeds and their possible negative correlation with other traits.

Topic: Milk Quality and Mastitis in Dairy Cows
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
THE NAKED NECK FOWL

SUMMARY The genetic value of ancient breeds of livestock is recognized increasingly all over the world. This seems especially important in the case of domestic fowl where hybrids are increasingly dominating everywhere. This paper describes some old Hungarian breeds. Within the species of domestic fowl in Hungary the following breeds should be taken into consideration for preservation: the three colour variants white, yellow and speckled - of improved fowl, already classified as individual breeds called White Hungarian, Yellow Ijungarian and Speckled Hungarian, respectively. The white and speckled breeds both have a naked neck variety too The Transylvanian Naked Neck, although similar to the above variants, is oi different origin.

Topic: Animal Nutrition and Physiology
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
DFM: where's the proof of value?

How can design teams employ new tools and develop response methodologies yet still stay within design budgets? How much effort does it require to be an early adopter and what kind of measurable results compensate for this effort? Panelists discuss how their design-for-manufacture (DFM) tools fit into a fixed design methodology, budget and timeline, and give examples of expected ROI (monetary, quality, reduced time-to-market, and comprehensive yield). The aim of this panel is to provide a serious comparison of related DFM technologies on the market and some idea of the cost and difficulty of integrating the tools into a fixed design budget and timeline. Specific results are cited, along with examples of expected ROI (monetary, quality, reduced time-to-market, and comprehensive yield enhancement). The audience should walk away with enough information to make an informed decision on which companies would make sense for their DFM challenges, to reach their own yield and throughput goals.

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Evaluation of an in-house indirect immunoperoxidase test for detection of antibodies against African swine fever virus

African swine fever (ASF) is a high-consequence transboundary animal disease caused by African swine fever virus (ASFV). Given that vaccines are not widely available, ASFV detection, including by molecular and serologic assays, is paramount to efficacious control and mitigation of ASF. ASFV-specific antibodies can be detected as early as 7–10 d postinfection in infected animals and may persist for several months or longer. Accurate detection of ASFV-specific antibody is critical for the identification of chronically infected, subclinically infected, or recovered animals. ELISAs are commonly used for the rapid screening of large numbers of animals for ASFV antibodies. The World Organisation for Animal Health recommends that ELISA-positive results should be confirmed with a second serologic method, such as an indirect immunofluorescent assay, indirect immunoperoxidase test (IPT), or immunoblot test. Commercial kits are not available for those tests. We developed and validated an in-house IPT by using a currently circulating genotype II ASFV strain as antigen. The sensitivity and specificity of the in-house IPT are comparable to the reference IPT developed by an international ASFV reference laboratory and superior to a commercial blocking ELISA.

Topic: Animal Disease Management and Epidemiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) are associated with vasculitis. Current therapy involves administration of toxic therapy that is not optimally effective. The review will summarize evidence for the pathogenicity of ANCA, which will suggest possible strategies for improving treatment.

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
The Effect of Prangos Ferulacea Vaginal Cream on Accelerating the Recovery of Bacterial Vaginosis: A Randomized Controlled Clinical Trial

Background: The present study was conducted on the effect of prangos ferulacea vaginal cream on accelerating the recovery of bacterial vaginosis. Methods: This randomized controlled clinical trial was conducted on 100 non-pregnant women referring to health centers affiliated to Lorestan University of Medical Sciences in 2016 with the diagnosis of bacterial vaginosis based on the patient’s complaints, Amsel’s clinical criteria, and the Nugent microscopic criteria. The women were randomly divided into two groups of 50. One group was treated with oral metronidazole plus Prangos ferulacea vaginal cream and the other with oral metronidazole plus a placebo vaginal cream for seven days. The patient’s complaints, Amsel’s clinical criteria and the Nugent microscopic criteria were assessed seven days after treatment. The data were analyzed using SPSS, version 20, with a significance level of 0.05. Results: The response to oral metronidazole plus Prangos ferulacea vaginal cream treatment was 94% according to Amsel’s clinical criteria and 88% according to the Nugent microscopic criteria. The response to oral metronidazole plus placebo vaginal cream treatment was 94% according to Amsel’s criteria and 86% according to the Nugent criteria. The analysis of the patients’ complaints, Amsel’s clinical criteria and the Nugent microscopic criteria showed significant differences in each group before and after the treatment. Conclusion: This trial showed that Prangos ferulacea vaginal cream accelerated the recovery of bacterial vaginosis of patients with bacterial vaginosis. It can be used effectively as a complementary treatment with oral metronidazole in cases of medication resistance and also in people wishing to use herbal remedies Trial Registration Number: IRCT2016042327534N1

Topic: Garlic and Onion Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Talking about School Transition (TaST): an emotional centred intervention to support children over primary-secondary school transition

Transitions are an unavoidable part of life, often conceptualised as ‘make it or break it periods’. They are important for personal growth and learning but can also be damaging in terms of our psychological wellbeing. Primary-secondary school transition is no exception and can heavily draw on children’s ability to cope. However, support for children that pays attention to their feelings about the transfer is often lacking. Very few interventions focus on developing children’s emotional resilience. There are also problems with the sustainability of such interventions. Thus, the present emotional-centred intervention, Talking about School Transition (TaST), aims to narrow this gap. The evaluation of the intervention is ongoing and will be reported in a separate publication. Following an introduction of the limitations in supporting children’s emotional well-being over primary-secondary school transition within schools, this paper provides details of the TaST intervention, including a brief description of the lessons’ content. Attention is given to the design of the TaST intervention and how preliminary research, in combination with psychological theory and existing research, have informed the intervention content. The proposed research has short-term implications for present participating Year 6 children’s adjustment and provides professionals working in schools with the knowledge and resources necessary to deliver TaST. In addition to this, the research has long-term implications for the field in highlighting the importance of supporting children’s emotional wellbeing over this period.

Topic: Early Childhood Education and Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Health Promotion and Disease Prevention

FIFTEEN YEARS ago, the US Department of Health, Education, and Welfare published<i>Healthy People: The Surgeon General's Report on Health Promotion and Disease Prevention</i><sup>1</sup>as a primary strategy for improving the health of US citizens and emphasizing health promotion as an essential element of the prevention imperative. In 1991, the publication of<i>Healthy People 2000: National Health Promotion and Disease Prevention Objectives</i><sup>2</sup>set forth priorities and specific objectives for health promotion, health protection, and preventive services and developed goals to enhance quality of life, decrease preventable death and disability, achieve universal access for preventive services, and reduce disparities in health status. Today, with clinicians, researchers, analysts, and policy makers striving to develop health care systems that provide accessible, affordable, and comprehensive health care, the concepts of health promotion and disease prevention have emerged at the forefront of the reform debate and are receiving greater attention than perhaps ever

Topic: School Health and Nursing Education
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
Retrospective study of the relative frequency of cattle respiratory disease pathogens in clinical laboratory samples submitted by UK veterinary practices

Abstract Background The objective of this study was to explore the relative frequency and seasonality of bovine respiratory pathogens in the UK, based on clinical case submission for laboratory PCR testing. Methods This study used retrospective data generated by a central Scotland laboratory using 407 clinical (pooled) samples collected by 95 veterinary practices located throughout the UK between November 2020 and September 2022. Statistical analyses were performed using descriptive spatial analysis (choropleth maps), chi‐squared analysis, Poisson and logistic regression modelling. Results The majority (77.6%) of the samples had more than one species of bacteria identified, and 17.7% had multiple viruses identified. In comparison with the colder months of autumn and winter (September to February), the warmer months (March to August) were significantly associated with lower odds of respiratory disease caused by certain pathogens. Poisson models showed small but significant univariable associations between total viruses (coefficient = ‒0.01, standard error [SE] = 0.004, 95% confidence interval [CI] = ‒0.02 to ‒0.003) and total pathogens (coefficient = ‒0.005, SE = 0.002, 95% CI = ‒0.008 to 0.002) and increasing weekly age. Limitations This is an inherently biased population because it only comprises clinical samples submitted to a single UK laboratory, and the data were analysed retrospectively. Conclusions A large majority of clinical bovine respiratory disease (BRD) samples were multipathogenic, and pathogens such as bovine coronavirus (which has generally not been considered a significant contributing pathogen in the BRD complex in the UK) were prevalent.

Topic: Microbial infections and disease research
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
A Novel Topology forMultiple Output DC-DC Converters forOne CycleControl

Multiple output DC-DCconverters areneededby manyutilities/ industry applications. TheControl ofmultiple output converters ischallenging astheoutputs derive theinput powerformsamesource andthereby haveastrong coupling. A novelMultiple Outputconverters topology hasbeenproposed to havedecoupling ofoutputs fromindividual control. A closed loop control hasbeensuggested fortheproposed converter suchthatit hasonecycle control ofalltheoutputs individually aswellas collectively. The proposed converter hasbeenverified by simulation andexperimentation. IndexTerms-- DC-DCConverter.

Topic: Advanced DC-DC Converters
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Trends of Media Coverage about Libraries in Korea: Using Semantic Network Analysis of Portal News

Abstract The purpose of this study is to understand the trends and problems of media coverage about Korean libraries by selecting keywords from Korean portal news articles and conducting semantic network analysis. As a result, Korean news reports focus on public libraries rather than school and university libraries. Elsewhere, libraries’ lifelong learning program performance, such as cultural events and educational lectures, are overly biased on press release. In addition, news articles in all kinds of libraries are dominated by simple publicity about businesses or events rather than policy issues about library laws, budgets and manpower. Korea’s libraries reflected in the media are analyzed as cultural and social educational institutions rather than knowledge information centers.

Topic: Educational Systems and Policies
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Supplementary data from Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies

&lt;p&gt;Supplementary file containing Supplementary materials and methods, supplementary figure legends and supplementary references.&lt;/p&gt;

Topic: Connective tissue disorders research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Monitoring the organizational wellness of a physician residency program: A quality improvement process

Background Burnout and depression throughout physicians’ career cycles have been increasing. There has been a call for medical education leaders to devote resources to bolster the next generation of providers and shift the culture of medicine to organizational initiatives that impact physician well-being. Objective: The goal of this project has been to monitor and improve the organizational wellness of a residency program based on four core organizational areas: (1) culture of meaning and mission, (2) work capacity, (3) control and flexibility in decision-making, and (4) creativity in work–life balance. Method: A quality improvement strategy was implemented to monitor organizational wellness. The wellness was assessed five times over the course of 18 months. The survey was designed to evaluate the four core components. At each time interval, improvement strategies were implemented to address the wellness drains and strengthen drivers. Results: The four time series evaluations (residents: n = 19) indicated that culture of meaning, teamwork, and personal creativity are consistent wellness drivers. Work capacity and lack of control over decision-making were consistent drains. From first until last measurement, there was a slight improvement in control-decision-making; however, the burden of electronic medical record (EMR) charting and strains of coverage continue to drain our residency. Discussion and Conclusions: This model incorporates four categories for assessing organizational wellness within a residency program. The conceptual model is used as a framework to define, measure, analyze, and improve on organizational wellness. This process provides programs with a feedback approach to continually monitor and reassess the wellness of the organizational systems.

Topic: Healthcare professionals’ stress and burnout
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
“It Shone with the Glory of the Lord”. On Beauty and Christian Telos

This chapter discusses whether two fields of study - eschatology and aesthetics - have intersected fruitfully enough. During its two thousand year journey, Christian theology has developed sophisticated proposals about the afterlife. The question is whether these visions have paid sufficient attention to beauty as a primary quality of the end. This exploration focuses on the relation between telos and beauty. The one focuses exclusively on God, with an emphasis on contemplation; the other one has a much greater emphasis on sensuality and on social relations and activity. Throughout history the eschatological imagination vacillated between these two directions, with ever new configurations. The seminal essay by Rahner on The Hermeneutics of Eschatological Assertions has rendered a valuable service in articulating the contours of such a consciousness. He stresses that eschatological knowledge is the experience of God's salvific action in Jesus Christ: Christ himself is the hermeneutical principle of all eschatological assertions. Keywords:christian telos ; divine beauty; eschatological imagination

Topic: Byzantine Studies and History
Subfield: Classics
Field: Arts and Humanities
Domain: Social Sciences
CLINICAL OBSERVATIONS WITH PROLONGED CONTINUOUS ADMINSTRATION OF NORETHISTERONE ACETATE.

48 women submitted to uninterrupted treatment with norethisterone ac etate (2.5 mg daily) for 2-24 months. The effects of this therapy on the endometrium and on the vagina is reported. 15 women had atrophic en dometrium and 11 had atypical endometrium. 5 vaginal biopsies showed n ormal stratified epithelium and 7 showed normal stratified epithelium w ith absence of the superficial karyopyknotic layer; the absence of the karyopyknotic layer occurred after 6 months of therapy. No pregnancies occurred; all women had breakthrough bleeding varying from 1 to 8 months followed by amenorrhea. 20 of 22 women with chronic pelvic pain prior to therapy showed complete relief of their pain. Defeminization occurred in 1 woman decrease in libido in 5 hot flushes in 5 introital dyspareunia in 2 and weight gain in 54%. Recovery of normal ovulation occurred in 15-50 days after cessation of treatment in most women.

Topic: Ovarian function and disorders
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Establishing World History as a Teaching Field: Comments from the Field

IN THE PAST TWENTY YEARS, world history advocates have persuaded states across the nation to replace western civilization courses in the public schools with world history. The trend to adopt world history courses is happening perhaps more rapidly than was anticipated. With some frustration, however, world historians are recognizing that the world history label on a course does not necessarily mean a global perspective is being taught in the classroom. If teachers were presenting a curriculum informed by a global perspective, by interpretations based on the work of world historians, and by teaching strategies that were tailored to the world history field, we might say that world history had been established as a teaching field. That clearly has not happened yet, because state curriculum committees, public schools and teachers seem to have settled for a curriculum that merely reflects the old western civilization paradigm rather than presenting a fresh and dynamic global approach to world history. What needs to be done to ensure that instruction reflects world historiography and that we move beyond old curricula? As a world history educator at the undergraduate and graduate level and a methods instructor for history/social science teacher candidates at a university with a long tradition of teacher training in California, I have compiled a series of

Topic: Educator Training and Historical Pedagogy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors as<i>in situ</i>tumor vaccine for colorectal cancer

Abstract Although cancers can naturally elicit immune responses, immune ignorance is a common observation preventing immune-mediated elimination of tumor cells. We assessed whether intratumoral expression of respiratory syncytial virus fusion (RSV-F) protein, encoded by a replication-defective adenovirus vector (Ad.RSV-F), alone or in combination with local coexpression of cytokines can induce tumor-specific immune responses in a syngeneic murine colon cancer model. We confirmed in vitro by dye colocalization that transduction of murine cells with Ad.RSV-F induces cell-cell fusion. In vivo, we showed in a bilateral syngeneic s.c. colon cancer model in C57BL/6 and BALB/c mice that intratumoral injection of Ad.RSV-F leads to a significant volume reduction not only of the directly vector-treated tumor but also of the contralateral not directly vector-treated tumor. The intratumoral administration of Ad.RSV-F in combination with adenovirus vectors encoding interleukin (IL)-2, IL-12, IL-18, IL-21, or granulocyte macrophage colony-stimulating factor significantly enhanced the antitumor effect on the directly vector-treated tumor and also on the contralateral tumor. The antineoplastic efficacy of this combined treatment was significantly higher than that of the individual treatment components and was associated with the induction of a tumor-specific CTL response and increased infiltration of the tumors by natural killer cells and macrophages. Intratumoral coexpression of RSV-F and IL-21 resulted in the highest tumor growth inhibition and improved survival. Our experimental data indicate that intratumoral expression of RSV-F in combination with cytokines is a promising novel tool for the development of in situ tumor vaccination approaches. [Mol Cancer Ther 2007;6(7):1942–50]

Topic: Virus-based gene therapy research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Do we need community geriatrics?

Community geriatrics has evolved as a specific aspect of geriatric medicine in the UK. In Ireland there is uncertainty as to how it should be planned. This is the first national survey of consultants, specialist registrars and general practitioners to seek their opinions. Most consultants and GPs reported already having a community aspect to their current practice, e.g. nursing home visits or community hospital visits, whereas most SpRs did not. Forty three of 62 respondents (69%) agreed that there is a need for community geriatricians and that there should be integration with hospital medicine. Fifty seven of 62 respondents (92%) felt that there would be a beneficial effect on GP services, though some expressed concern about work overlap. Thirteen of the 25 SpRs (52%) in training hoped to begin practice in community geriatrics in the future.

Topic: Frailty in Older Adults
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences