jimnoneill/paper-to-field-training huggingface dataset:
[Autosomal dominant polycystosis in the hospital milieu in Dakar (Senegal)].

Autosomial dominant polycystic kidney disease (ADPKD) is an hereditary affection transmitted in a autosal dominant pattern with variable penetrancy. Diagnosis is based upon ultrasound examination and/or familial history. The authors present a 8 years retrospective hospital study in order to precise the epidemiological and clinico-biological aspects of ADPKD in Dakar. So 23 patients were studied. The mean age at the diagnosis was 46 years. They were 9 men and 14 women (sex ratio 0.64). A past history of familial nephropathy was found in 52.2% of cases. The circumstances of diagnosis were dominated by lombar pain (52.2%) and hypertension (17.4%) but at examination, blood pressure was high in 34.8% and represent the main factor of worsening the disease. Enlargement of kidney was found in 47.8% and hepatomegaly in 13% of cases. Anemia was particularly common 56.5%. The most frequent extra renal manifestation was the liver cysts and occurs mainly in women. National prevalence of ADPKD and the specific gene should be precise in further studies.

Topic: Genetic and Kidney Cyst Diseases
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Molecular Characterization of Efflux Pump and Porin Related Genes in Multidrug Resistance Klebsiella pneumoniae Isolates Recovered from Erbil Hospitals

Background: Multidrug-resistant efflux pumps are one of the most significant methods by which bacteria can evade the effects of numerous antimicrobials. The aim of this study was to determine the prevalence of multidrug-resistant MDR, extremely drug-resistant XDR, and pan-drug-resistant PDR K. pneumoniae phenotypes in clinical isolates, as well as to examine the detection and prevalence of efflux pump genes ompK35, ompK36, tolC, and acrAB in multidrug-resistant K. pneumoniae strains.&#x0D; Materials and Methods: This study was conducted on 60 isolates of K. pneumoniae collected from different clinical samples in Erbil hospitals. The frequency of MDR, XDR, and PDR K. pneumoniae phenotypes was characterized through an antibiotic susceptibility profile, and genes associated with efflux pumps and porins were detected by polymerase chain reaction (PCR) assay.&#x0D; Results: All 60 K. pneumoniae isolates were resistance to one or more classes of antibiotics tested in this study. The maximum resistance was observed with ampicillin (95%), followed by piperacillin acid (83%). Among all isolates the percentage of MDR, XDR, and PDR were (38%), (37%), and (25%) respectively. Furthermore, the distribution of efflux pump genes was acrAB (95%) and tolC (93%), while the prevalence of porin-coding genes ompK35 and ompK36 were (80%) and (82%) respectively.&#x0D; Conclusion: Prevalence of MDR, XDR, and PDR K. pneumoniae strains in Erbil city is worrisome in hospital wards. Furthermore, Genes encoding efflux pump and porins such as acrAB, tolC, ompk35, and ompK36 were highly distributed among all isolates.

Topic: Antibiotic Resistance in Bacteria
Subfield: Molecular Medicine
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A convenient access to fluorophosphonium triflate salts by electrophilic fluorination and anion exchange

The <italic>in situ</italic> one-pot electrophilic fluorination of phosphanes with NFSI followed by anion exchange with MeOTf gives highly electrophilic fluorophosphonium triflates – highly efficient catalysts for the synthesis of <italic>N</italic>-sulfonylamidines from amides.

Topic: Chemical Synthesis and Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Is Teaching Residents How to Code a Valuable Intervention? [16N]

INTRODUCTION: Appropriate documentation is an important component of quality health care. In academic medical centers, most documentation is done by residents. Given the scope of topics for resident education, a formal curriculum for documentation is often non-existent. Poor documentation has important consequences, including financial loss and compromise of quality indices. We sought to determine if instructing residents in basic coding principles improved the rate of appropriate documentation for early-term deliveries. METHODS: Residents were given a one-hour lecture focused on inpatient documentation, with a section on documenting appropriate justification for early-term deliveries. Subsequent documentation over a one-week period by each of the second- and third-year residents in attendance (n=7) was reviewed, and the rate of appropriate documentation for early-term deliveries was compared to similar documentation prior to the intervention for the same residents. This was compared to documentation by second- and third-year residents who did not attend the lecture (n=9). RESULTS: There were 153 total encounters analyzed. 29 were for patients who underwent early-term delivery. Of the pre-intervention early-term deliveries, the reasons for delivery in 8/13 (61.5%) were incorrectly documented. Of the post-intervention early-term deliveries, the reasons for delivery in 6/16 (37.5%) were incorrectly documented. 5/6 (83.3%) of the post-intervention early-term deliveries which were incorrectly documented were by residents who had not attended the lecture. CONCLUSION: Teaching residents coding and formal documentation is a valuable intervention. These simple interventions stand to make a significant impact on both financial and quality indices. These interventions will also serve to better prepare trainees for their transition into practice.

Topic: Primary Care and Health Outcomes
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Sandis, Aristidis C., (born 1 Dec. 1951), Ambassador of Greece to the Court of St James’s, 2010–12; Permanent Representative to the International Maritime Organization, 2010

"Sandis, Aristidis C., (born 1 Dec. 1951), Ambassador of Greece to the Court of St James’s, 2010–12; Permanent Representative to the International Maritime Organization, 2010" published on by Oxford University Press.

Topic: Maritime Security and History
Subfield: Transportation
Field: Social Sciences
Domain: Social Sciences
OP069 [Quality and Safety » Errors]: TARGETING ZERO MEDICATION ADMINISTRATION ERRORS IN PEDIATRIC INTENSIVE CARE UNIT: A QUALITY IMPROVEMENT PROJECT

Alali, H.; Ghezaywi, Z.; Mei Ling, C.; Esabia, J.; Al Ahmady, A.; Awani, M.; Murabi, I.; Mncube, O.; Menez, A.; Alsamri, A.; Al Shehri, A.; Antar, M.; Kazzaz, Y. Author Information

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Porcine milk small extracellular vesicles modulate peripheral blood mononuclear cell proteome in vitro

<title>Abstract</title> Small extracellular vesicles (EVs) are a subtype of nano-sized extracellular vesicles that mediate intercellular communication. EVs can be found in different body fluids, including milk. Monocytes internalize porcine milk EVs and modulate immune functions <italic>in vitro</italic> by decreasing their phagocytosis and chemotaxis while increasing their oxidative burst This study aimed to assess the impact of porcine milk EVs on the porcine peripheral blood mononuclear cells (PBMC) proteome. Porcine PBMC were incubated with porcine milk EVs or medium as a control. Extracted proteins were then analyzed using nano-LC-MS/MS. A total of 1584 proteins were identified. The supervised multivariate statistical analysis, sparse variant partial least squares – discriminant analysis (sPLS-DA) for paired data identified discriminant proteins (DP) that contributed to a clear separation between the porcine milk EV treated cells and control groups. A total of 384 DP from both components were selected. Gene Ontology (GO) enrichment analysis with ProteINSIDE provided the evidence that the DP with a higher abundance in porcine milk EVs, like TLR2, APOE, CD36, MFGE8, were mainly involved in innate immunity and EV uptake processes. These results provide a proteomics background to the immunomodulatory activity of porcine milk EVs and to the potential mechanisms used by immune cells to internalize them.

Topic: Extracellular vesicles in disease
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CCDC 672993: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Comparative Study between Intrathecal Low-dose Bupivacaine versus Lidocaine for Anorectal Surgery

Abstract Background: Historically, intrathecal lidocaine used to be the drug of choice for short procedure, but transient neurological symptoms (TNS) were observed during its use. This study was performed to determine whether low-dose bupivacaine is an acceptable alternative to lidocaine for anorectal surgery. Methods: Fifty nine patients; 30 males and 29 females scheduled for minor anorectal surgeries were randomly selected to receive either subarachnoid isobaric lidocaine 30 mg or hyperbaric bupivacaine 5.25 mg. Fentanyl 20 µg was added to both anaesthetics, and the total volume was diluted to 3 ml saline. Onset and highest dermatomal level of sensory block, quality of anaesthesia, incidence of hypotension, and time until T 12 regression, return of lower extremity motor function, ambulation, and micturition were recorded. TNS were evaluated 24 hours after surgery. Results: In this study, there was no significant difference in onset or recovery time between groups, but we observed a longer duration until return of lower extremity motor strength in patients receiving lidocaine. TNS that resolved spontaneously within 48 hours were observed in 2 patients in the lidocaine group but not detected by any patient in the bupivacaine group.

Topic: Anesthesia and Pain Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Trace Length is a Simple Uncertainty Signal in Reasoning Models

Uncertainty quantification for LLMs is a key research direction towards addressing hallucination and other issues that limit their reliable deployment. In this work, we show that reasoning trace length is a simple and useful confidence estimator in large reasoning models. Through comprehensive experiments across multiple models, datasets, and prompts, we show that trace length performs in comparable but complementary ways to other zero-shot confidence estimators such as verbalized confidence. Our work reveals that reasoning post-training fundamentally alters the relationship between trace length and accuracy, going beyond prior work that had shown that post-training causes traces to grow longer in general (e.g., "overthinking"). We investigate the mechanisms behind trace length's performance as a confidence signal, observing that the effect remains even after adjusting for confounders such as problem difficulty and GRPO-induced length bias. We identify high-entropy or "forking" tokens as playing a key role in the mechanism. Our findings demonstrate that reasoning post-training enhances uncertainty quantification beyond verbal expressions, and establish trace length as a practical confidence measure for large reasoning models.

Topic: Diabetes Management and Education
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Comprehensive Approach to High-Performance Server Chipset Debug

This article describes a comprehensive approach for silicon debug of a server chipset that includes a high-performance, third-generation chip-multithreaded (CMT) Sparc microprocessor. Efficiently debugging the chipset required a combination of debug features in silicon and system platforms, firmware support for debug, test generation tools, and debug data interpretation tools. Several useful lessons were learned in the process.

Topic: Parallel Computing and Optimization Techniques
Subfield: Hardware and Architecture
Field: Computer Science
Domain: Physical Sciences
Investigation and Management of Adnexal Masses in Pregnancy

Adnexal masses can be found in 0.19 to 8.8% of all pregnancies. Most masses are functional and asymptomatic and up to 70% resolve spontaneously in the second trimester. The main predictors of persistence are the size (&gt;5 cm) and the imagiological morphocomplexity. Those that persist carry a low risk of malignancy (0 to 10%). Most malignant masses are diagnosed at early stages and more than 50% are borderline epithelial neoplasms. Ultrasound is the preferred method to stratify the risk of complications and malignancy, allowing medical approach planning. Pregnancy and some gestational disorders may modify the levels of tumor markers, whereby their interpretation during pregnancy should be cautious. Large masses are at increased risk of torsion, rupture, and dystocia. When surgery is indicated, laparoscopy is a safe technique and should ideally be carried out in the second trimester of pregnancy.

Topic: Ovarian cancer diagnosis and treatment
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
On the decidability of the embedded multivalued dependency membership problem (database, automated deduction)

The decidability of the membership problem for embedded multivalued dependencies (EMVDs) is an open problem in relational dependency theory. Given a set of EMVDs, determine if another EMVD holds in any relation where the set holds.
A resolution-theoretic view is taken. The dependencies are viewed as clauses in Skolemized conjunctive normal form. Earlier work on the problem is recast in the resolution framework.
A resolution based version of Sadri and Ullman's chase procedure is developed. This procedure extends the deletion feature of the original chase. An original top-down counterpart which includes factoring and deletes resolvents containing function terms is shown to be complete. Some previously known results are more easily proven from this procedure.
Various results regarding axiom classes are given. In an attempt to find a smaller superclass than the template dependencies which contain the EMVDs and have a complete axiomatization, a canonical form for template dependencies is noted. It is shown that attempting to restrict the EMVDs by limiting the attributes in a partition produces no useful results.

Topic: Bayesian Modeling and Causal Inference
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Mental spillover in IT workplace: overthinking and organizational support in the work-family conflict and incivility link among employees in Chennai

Purpose This study aims to examine how work-family conflict (WFC) contributes to workplace incivility (WPI) in high-pressure information technology (IT) environments, emphasizing the mediating role of overthinking (OT) and the moderating effect of perceived organizational support (POS). This study aims to clarify the psychological and organizational mechanisms that transform strain into incivility. Design/methodology/approach A mixed-methods approach was used. The qualitative phase involved semi-structured interviews with 22 IT professionals to explore the psychological effects of WFC. Insights from this phase informed a quantitative survey administered to 410 IT employees in Chennai, India. Structural equation modeling and the PROCESS macro were used to test a moderated mediation model grounded in the conservation of resources theory. Findings The results indicate that OT significantly mediates the relationship between WFC and WPI. Additionally, POS moderates this indirect effect such that the positive association between OT and incivility is weaker when organizational support is perceived as high. Research limitations/implications The cross-sectional nature of this study limits causal interpretation. Future research may benefit from longitudinal designs and larger industry samples. This study contributes to the literature by integrating psychological strain and organizational context into the WFC-incivility link. Practical implications Organizations can reduce incivility by supporting employees facing WFC through stress management interventions and POS-enhancing human resource practices. Promoting support structures may buffer cognitive overload and improve workplace behavior. Originality/value This study offers a novel moderated mediation model explaining how OT links WFC to incivility and how POS attenuates this effect, especially relevant for knowledge-intensive sectors like IT.

Topic: Employment and Welfare Studies
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of <i>k-ras</i> Mutation Status

Abstract Purpose: Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal cancers. We have previously shown successful targeting therapy for colorectal, pancreatic, gastric, and esophageal carcinomas using recombinant adenoviruses expressing dominant negative IGF-IR. Mutation in k-ras is one of key factors in gastrointestinal cancers. In this study, we sought to evaluate the effect of a new monoclonal antibody for IGF-IR, figitumumab (CP-751,871), on the progression of human gastrointestinal carcinomas with/without k-ras mutation. Experimental Design: We assessed the effect of figitumumab on signal transduction, proliferation, and survival in six gastrointestinal cancer cell lines with/without k-ras mutation, including colorectal and pancreatic adenocarcinoma, esophageal squamous cell carcinoma, and hepatoma. Combination effects of figitumumab and chemotherapy were also studied. Then figitumumab was evaluated in the treatment of xenografts in nude mice. Results: Figitumumab blocked autophosphorylation of IGF-IR and its downstream signals. The antibody suppressed proliferation and tumorigenicity in all cell lines. Figitumumab inhibited survival by itself and up-regulated chemotherapy (5-FU and gemcitabine) induced apoptosis. Moreover, the combination of this agent and chemotherapy was effective against tumors in mice. The effect of figitumumab was not influenced by the mutation status of k-ras. Figitumumab reduced expression of IGF-IR but not insulin receptor in these xenografted tumors. The drug did not affect murine body weight or blood concentrations of glucose, insulin, IGF binding protein 3, and growth hormone. Conclusions: IGF-IR might be a good molecular therapeutic target and figitumumab may thus have therapeutic value in human gastrointestinal malignancies even in the presence of k-ras mutations. Clin Cancer Res; 17(15); 5048–59. ©2011 AACR.

Topic: Growth Hormone and Insulin-like Growth Factors
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
<i>Form‐Nostoc</i>

Nos ' toc . M.L. n. Nostoc origin uncertain, supposedly invented by Paracelsus from the old English word Nosthryl (nostril) and the corresponding German word Nasenloch = Nostoch . Cyanobacteria / Subsection IV / Subsection IV.I / Form‐ Nostoc

Topic: Biocrusts and Microbial Ecology
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
THE INVESTIGATION OF SYNTHESIZED PROCESSING CONDITIONS ON SrTiO_3 SYSTEMS MID-HIGH VOLTAGE CAPACITOR CERAMICS

In this paper the synthesized processing conditions on SrTiO\-3 systems mid-high voltage capacitor ceramics are investigated.The results showed that the 2B4-2000 ceramic materials is synthesized via aone calcining processin order to obtain excellent dielectric properties,whose main specifications are as following:\;e 20℃ ≥2000 tgδ40×10\+\{-4\} ρv≥10\+\{12\}Ω·cm Δe/e 20℃ ±10% E\-b9kv/mm

Topic: Ferroelectric and Piezoelectric Materials
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Theory and Practice of Burning Solid Biofuels in Low-Power Heating Devices

Combustion is the most advanced and proven method on the market for using agricultural by-product residues and waste from the agri-food industry. Currently, a wide range of combustion technologies is used to produce heat and electricity in low-power heating devices (&gt;50 kW) using various types of biofuels from biomass (woody biomass, herbaceous biomass, waste and residues from the agri-food industry). Combustion of biomass fuels, especially those of wood origin, causes lower carbon dioxide (CO2) and sulfur oxides (SOx) emissions into the atmosphere compared to coal combustion. The growing interest in solid biofuels has contributed to intensive activities on improving the combustion process and energy devices enabling effective and economic conversion of chemical energy contained in biomass into other usable forms such as heat, electricity. Having good quality fuel, it is necessary to ensure an appropriate, clean combustion technique, which allows to achieve the highest thermal efficiency of the heating device and at the same time the lowest emission of pollutants. The article presents issues related to the theory, characteristics of the combustion process and problems related to the formation of harmful chemical compounds nitrogen oxides (NOx), SOx, carbon monoxide (CO), particulate matter (PM) emitted to the atmosphere during the combustion process in low-power heating devices. The analysis indicates the possibility of minimizing undesirable phenomena during the combustion of these biofuels related to ash sintering, the formation of deposits, corrosion and improving the amount of condensable solid particles formed and therefore reducing the emission of gaseous products to the environment.

Topic: Thermochemical Biomass Conversion Processes
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Building destination resilience through community and organizational resilience

This chapter argues that destination resilience can be conceptualized through the lenses of community and organizational resilience. However, there are multiple views of destination resilience, including socio-ecological and urban, that cannot be ignored. Regardless of how researchers conceptualize destination resilience, two underlying aspects are the vulnerability and coping capacity of the destination to external stressors. In post-conflict destinations, these stressors are often exacerbated by the socio-cultural and political environments. This chapter proposes a model of destination resilience, based on vulnerability and coping capacity, grounded in linkages between community and organizational resilience. It is argues that the resilience of organizations feeds into the resilience of communities; in turn, both contribute to destination resilience. Organization resilience is very much dependent on the resilience of employees, while the resilience of communities is dependent on both the resilience of individuals and that of organizations.

Topic: Disaster Management and Resilience
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences