jimnoneill/paper-to-field-training huggingface dataset:
Anti-inflammatory Effects of Magnolia sieboldii Extract in\nLipopolysaccharide-Stimulated RAW264.7 Macrophages

Purpose: To investigate the effect of Magnolia sieboldii extract\n(MSE) on the production of pro-inflammatory cytokines by macrophage.\nMethods: The whole plant of M. sieboldii was extracted with methanol at\nroom temperature. The in vitro anti-inflammatory activity of MSE was\ninvestigated on lipopolysaccharide (LPS)-stimulated RAW264.7\nmacrophages. LPS-induced nitric oxide(NO) production was determined by\nGriess method. Production of pro-inflammatory cytokines including\nInterleukin-1 beta (IL-1 β), Interleukin-6 (IL-6), tumor necrosis\nfactor- alpha (TNF-α) and cyclooxygenase-2 (COX-2) was examined\nusing reverse trancriptase - polymerase chain reaction (RT-PCR) and\nWestern blot analysis. Results: Under in vitro conditions, MSE in doses\nranging from 25 - 100 μg/mL significantly inhibited\nlipopolysaccharide (0.5 μg/mL)-induced nitric oxide production (p\n&lt; 0.001), and the production of pro-inflammatory mediators (p &lt;\n0.05). Conclusions: The anti-inflammatory effect of MSE on\npro-inflammatory cytokines seems to ameliorate inflammatory symptoms\nvia immune regulation.

Topic: Magnolia and Illicium research
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Assessing Students’ Ethnicities and Critical Thinking Skill to Develop PBL Based-Biology Learning Tools

A survey has been conducted in grade XI natural science of senior high school, at odd semester, academic year 2016/2017 in Samarinda, Indonesia. The focus of this research are to determine the students’ ethnicities, and the responses of biology teachers about students' critical thinking skills, and Problem-Based Learning. Sampling technique was total sampling. The research instrument was a questionnaire. Data was analysed by techniques used descriptive. The results of the data analysis show that the compositions of students’ ethnics are: Java (12.7%), Bugis (6.9%), Kutai (13.3%), Banjar (13.3%), and other ethnics (28.5%). Most of the teachers (86.0%) who already understood about the learning approaches, said that they already understood, while the remaining 14% did not understand the patterns of Problem-Based Learning. In addition, 23.3% teachers said that students were less able to explain, express opinions, and make conclusions; 76.7% said that students are sufficiently able to explain, express opinions, and make conclusions. Future research related to biology learning in multiethnic students needs to be conducted to get more information. The design of learning tools needs to consider the ethnic of the students in strengthening critical thinking skills. Similar research needs to be done to obtain more information.The findings of this research are the students’ ethnicities of the XI class of Natural Sciences, as well as the responses of high school biology teachers about students' critical thinking skills in Biology.

Topic: Education and Critical Thinking Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
"Breakthrough" as Critique of Form: The Finale of Mahler's First Symphony

Research Article| October 01 1996 "Breakthrough" as Critique of Form: The Finale of Mahler's First Symphony James Buhler James Buhler Search for other works by this author on: This Site PubMed Google Scholar 19th-Century Music (1996) 20 (2): 125–143. https://doi.org/10.2307/746904 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation James Buhler; "Breakthrough" as Critique of Form: The Finale of Mahler's First Symphony. 19th-Century Music 1 October 1996; 20 (2): 125–143. doi: https://doi.org/10.2307/746904 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Content19th-Century Music Search This content is only available via PDF. Copyright 1996 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Musicology and Musical Analysis
Subfield: Music
Field: Arts and Humanities
Domain: Social Sciences
Steroid Dependent Ulcerated Erythema Nodosum Leprosum 16 Years after Successful Treatment of Leprosy

Leprosy could be best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses. The second is lepra reaction, whose course and sequelae often extend many years beyond the cure of the infection and may have severely debilitating physical, social, and psychological consequences. Type-2 lepra reaction is also termed Erythema nodosum leprosum (ENL) regardless of the site of involvement, which is in turn a Coomb and Gell Type III hypersensitivity reaction. The paradox of ENL is that it can be a life-threatening disorder and requires control with immunosuppression which may itself pose life-threatening risks for patients Indian studies found its prevalence rate of almost 50% in those with LL and 9% in BL cases and the mean time to presentation with ENL was 3.7 months after starting multi-drug therapy (MDT). Hitherto we report a severe and steroid dependent case of chronic ulcerated ENL, not only occurred sixteen years after successful treatment of lepromatous leprosy, but also had an unusual initial presentation of arthritis. To the best of our knowledge, ENL for such a prolonged period of 15 years was not reported earlier. Â doi:10.3329/jom.v10i1.2002J Medicine 2009; 10: 31-33

Topic: Leprosy Research and Treatment
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Paleocene dinoflagellates from the turtle mountain formation, southwestern Manitoba, Canada

Abstract Shallow marine deposits of the Paleocene Turtle Mountain Formation on the northeastern flank of the Williston Basin, southwestern Manitoba, yielded dinoflagellate assemblages which include Senegalinium microgranulatum, S. obscurum, Senegalinium sp., Spinidinium densispinatum, S.? pilatum, Cerodinium speciosum, Isabelidinium viborgense and Phelodinium magnificum. The assemblages indicate that the Turtle Mountain Formation is Early to early Late Paleocene in age. Low species diversity and high dominance of a few species are characteristics of the assemblages and suggest a nearshore depositional environment for the formation. Additional investigation of dinoflagellates of the Cannonball Formation in southcentral North Dakota confirms an early Late Paleocene age which permits correlation of the Cannonball Formation with the upper part of the Turtle Mountain Formation. Distinct similarities are present in dinoflagellate assemblages of Paleocene marine deposits within the Williston Basin. The assemblages also have marked similarities with Paleocene assemblages of the eastern Gulf Coastal Plain, U.S.A., which suggests extension of the Gulf sea into the Williston Basin during the Paleocene.

Topic: Marine Biology and Ecology Research
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
United States-Iran Relations: The Trump Impact

In spite of the ongoing enmity between the United States (U.S.) and Iran, the signing of the 2015 nuclear deal during the Presidency of Barack Obama was a turning point that had a potential to repair the bilateral relations. On the other hand, President Donald Trump’s decision to withdraw from the deal in 2018 dashed hopes of many for the stabilization of bilateral relations as well as the containment of the nuclear threat. Recently, President Joe Biden’s potential reengagement with Iran is being questioned, even though the use force might still be an attractive choice. In that context, the article will shed light on the U.S.-Iran relations during the Presidencies of Obama, Trump and Biden respectively. Thus, the fluctuation in recent bilateral relations will be understood from a comparative perspective. It is argued that the anti-Iran strategy of Trump pushed the bilateral relations into a stalemate and his foreign policy legacy prevailed over the efforts to reconcile with Iran by both Obama and Biden administrations.

Topic: Economic Sanctions and International Relations
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Is there a role for the radiologist in dermatology?

There are at least 100 entities that present a significative conjunction between skin signs and skeletal or other bony changes that can be detected by radiological means (skin and bones and others). The aim of this article is to underline that sometimes a radiological examination could guide to a correct diagnosis in dermatology. In addition, bloody diagnostic procedures could be avoided in ambiguous skeletal lesions if the radiologist remembers that skin and bone diseases exist. We review the literature and suggest a practical classification, including skin markers of occult radiological changes, skin diseases often associated with skeletal or other bony changes that require a radiological evaluation for a diagnosis, radiological changes mimicking cutaneous diseases, skeletal side effects of dermatological therapies (topical and systemic) and skin lesions occurring as a consequence of bone injury.

Topic: Genital Health and Disease
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Dietary Fat Predicts Conversion From Impaired Glucose Tolerance to NIDDM: The San Luis Valley Diabetes Study

OBJECTIVE To determine if dietary fat intake measured at a baseline exam in subjects with impaired glucose tolerance (IGT) predicted the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS Based on an oral glucose tolerance test (OGTT) (World Health Organization criteria), we identified 134 eligible subjects with IGT from a geographically based sample of subjects with no prior history of diabetes. One to three years after the baseline exam, 123 subjects (92%) had a repeat OGTT. Diet was assessed by a 24-h diet recall reported before the baseline OGTT. RESULTS The mean percentage of energy eaten as fat was 43.4% in 20 people subsequently developing NIDDM compared with 40.6% in 43 people remaining IGT and 38.9% in 60 subjects who subsequently reverted to normal glucose tolerance. In comparing the 20 subjects who developed NIDDM with the 103 who remained IGT or normal, an increase in fat intake of 40 g/day was associated with an increase in risk of NIDDM of 3.4-fold (95% confidence interval [CI] 0.8–13.6) adjusted for energy intake, age, sex, ethnicity, and obesity. The odds ratio increased to sixfold (95% CI 1.2–29.8) after adjustment for fasting glucose, insulin, and 1-h insulin. CONCLUSIONS Fat consumption significantly predicts NIDDM risk in subjects with IGT after controlling for obesity and markers of glucose metabolism.

Topic: Nutritional Studies and Diet
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Battery Charging Method

A charging and equalizing method for a battery having a control computer in a charging system in communication with a plurality of module processors. Charging and equalization pauses periodically for voltage measurement by the module processors. The control computer determines when to equalize battery cells in the modules based on their open circuit voltages transmitted by the module processors. A selected group of cells in each module can be equalized. Equalization is carried out in the modules until all of the module processors indicate that equalization has been completed. Charging can then resume until charging is complete or cells reach a maximum voltage given by the control computer. In an alternative embodiment, a selected group of cells may be partially bypassed while charging to reduce the charge rate of the cell.

Topic: Advanced Battery Technologies Research
Subfield: Automotive Engineering
Field: Engineering
Domain: Physical Sciences
2955 – Europe Challenges the Burden of Mental Disorders

Time based composite measures of disability have replaced the traditional use of death rates to evaluate society's mental health status as a more meaningful measures for the burden of diseases and the need for treatment and care. These measures have revealed with some variability and increasing precision that mental and neurologic disorders account for a major and further increasing proportion of the all-cause disability burden worldwide. In Europe, mental and neurologic conditions combined are already now the most disabling diseases. A recent pan-European study covering 30 countries and the EU-population of 514 million people, recently examined comprehensively the size and burden and cost of mental and other “disorders of the brain”. Findings e. g.: Each year, 38.2% of the EU population (64.8 million people) suffers from a mental disorder. The treatment situation remains highly deficient. Only 1/3 of all cases affected receive treatment, those receiving treatment do so with considerable delays of several years and rarely with appropriate, state-of-the-art therapies Additionally, many millions patients suffer from neurologic disorders such as stroke and Parkinson's disease, cases that may add on top of the above estimates. The total cost burden is immense (approx 800 billion €), mainly due to indirect costs. The low direct (treatment) cost proportion is unique to mental disorders and markedly different from other prevalent somatic diseases (e.g. cancer, diabetes).

Topic: Mental Health Treatment and Access
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Ring coupling model: Implications for the ground state of the magnetosphere

The ring coupling model predicts that the radius of the polar cap remains appreciable down to very small values of the transpolar potential Φ and then decreases rapidly to zero as Φ goes to zero. Electric field data from the S3‐2 spacecraft are shown to be consistent with the prediction in that both the theory and the data show a weak dependence of polar cap radius on potential in the observed range. This behavior leads to theoretical insights about the ground state of the magnetosphere. Because the theoretical ground state (Φ = 0) has no polar cap, the model implies that the finite polar cap observed after extended periods of northward interplanetary magnetic field (IMF) is the result of a small potential being generated continually by the solar wind. If it is assumed that this potential is generated on closed magnetic field lines by some viscouslike interaction, and the bulk of potential is generated sporadically by magnetic merging, then the model implies that the polar cap retains open flux during extended periods of northward IMF and that it does so because of the presence of the potential generated by the viscouslike interaction.

Topic: Geomagnetism and Paleomagnetism Studies
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Study of Steady State for Distance Headway

Generally speaking, traffic headway comprises distance headway and time headway, which varies according to velocity and acceleration. Distance headway is a part of the traffic follow model as an expression of the stimulus-response factor. A more responsive driver accelerates and decelerates more frequently in response to the vehicle in front, thereby reducing the capacity of the traffic lane. This study attempts to calculate the distance headway in both the Macro Traffic Model and the Micro Traffic Model, and thus determine a steady state for the distance headway. The research results show that the Macro Traffic Model reaches Steady State at 20-23 seconds and the Micro Traffic Model reaches Steady State at 19-23 seconds. This research can be applied to traffic planning, calculation of crossroad traffic saturation rates, or in traffic simulation applications.

Topic: Traffic control and management
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
The Influence of Interdependence on Trust Calibration in Human-Machine Teams

In human-machine teams, the strengths and weaknesses of both team members result in dependencies, opportunities, and requirements to collaborate. Managing these interdependence relationships is crucial for teamwork, as it is argued that they facilitate accurate trust calibration. Unfortunately, empirical research on the influence of interdependence on trust calibration during human-machine teamwork is lacking. Therefore, we conducted an experiment (n=80) to study the effect of interdependence relationships (complete independence, complementary independence, optional interdependence, required interdependence) on human-machine trust calibration. Participants collaborated with a virtual agent during a simulated search and rescue task in teams characterized by one of the four interdependencies. A machine-induced trust violation was included in the task to facilitate dynamic trust calibration. Results show that the interdependence relationships during human-machine teamwork influence perceived trust calibration over time. Only in the teams with joint actions (optional and required interdependence) does perceived trust in the machine not recover to its initial pre-violated value. However, results show that the correlation between perceived trust in the machine and machine trustworthiness is strongest in these teams with joint actions, suggesting a more accurate trust calibration process. Overall, our findings provide some first evidence that interdependence relationships during human-machine teamwork influence human-machine trust calibration.

Topic: Human-Automation Interaction and Safety
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
A user-independent sensor gesture interface for embedded device

Sensor based gesture interaction gains increasing attention in ubiquitous computing; however most algorithms suffer from large database for training and user dependency limitation. This paper summarize the gesture generating model, and propose a new physical analysis based gesture recognition method which can fulfill user-independent no-training gesture recognition. It utilizes principle component analysis for energy distribution analysis to bypass the gratitude influence, and extracts the physical characteristics of the gesture trajectory for classification. In our real-time gesture recognition system, first the acceleration data of a gesture is collected through Bluetooth interface between Wii-Remote and PC; then the energy distribution shape is calculated, then several physical trajectory characteristic is organized as motion feature cascade classification. The proposed method is compared with the published method under the Nokia dataset, whose recognition accuracy could achieve 97.35% for user-independent situation.

Topic: Hand Gesture Recognition Systems
Subfield: Human-Computer Interaction
Field: Computer Science
Domain: Physical Sciences
Ingestion of topical steroid triggering pustular psoriasis?

Conflicts of interest: none declared. Sir, A 7‐year‐old girl was admitted as an emergency under the care of the paediatricians, with painful erythroderma, systemic upset and pyrexia of up to 40 °C. She had a history of special educational needs and hyperactive behaviour, and had previously been treated for psoriasis by her general practitioner (GP), although she had not needed to use any topical therapy for 6 months. There was a strong family history of psoriasis, with both her mother and her maternal grandmother affected. Seven days prior to admission she had ingested more than half of a 100‐g tube of clobetasone butyrate (Eumovate®; GlaxoSmithKline, Uxbridge, U.K) belonging to her mother. Forty‐eight hours after this she began to develop redness and scaling initially on the face and subsequently on the lower limbs. When the GP was consulted the following day pustules were noted, and oral flucloxacillin suspension 125 mg four times daily was commenced along with topical Aqueous Cream. Despite these measures the rash became more widespread, resulting in admission.

Topic: Drug-Induced Adverse Reactions
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Abstract 6647: Targeting DCLK1-mediated glutamine addiction in chemoresistant ovarian cancer

Ovarian cancer (OC) presents significant therapeutic challenges due to its frequent late-stage diagnosis accompanied by distant metastases and the development of chemoresistance. As existing FDA-approved targeted therapies for OC do not adequately address peritoneal metastases, there is an urgent need for innovative treatment strategies that specifically target the molecular and cellular pathways underlying metastasis and disease recurrence. Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase with a demonstrated role in cancer cell stemness, epithelial-mesenchymal transition (EMT), disease progression in gastrointestinal and pancreatic cancers and resistance in ovarian and lung cancer. The study objective is to evaluate the functional role of DCLK1 in the peritoneal metastasis of OC and investigate the associated benefits of antagonizing it as a novel strategy to mitigate OC metastasis. Our prior studies demonstrate DCLK1 inhibition reduces the number of visible metastases in an orthotopic OC model in mice. In this study, we used pharmacological inhibition (DCLK1-IN-1), and genetic manipulation (DCLK1 CRISPR-knockout (KO) and over-expression systems) to assess the role of DCLK1 in promoting OC metastasis. We observed that elevated DCLK1 expression enhanced OC cell adhesion to different extracellular matrices including collagen, fibronectin, and laminin. Furthermore, DCLK1 inhibition effectively reduced mesothelial cell clearance relative to control. Targeted gene expression profiling and pathway analysis revealed DCLK1 inhibition in cisplatin resistant (CPR) OC spheroids upregulated genes involved in glutamine metabolism. Using metabolic flux assays, we demonstrated increased oxygen consumption in DCLK1 KO CPR cells that was abrogated by BPTES (glutamine oxidation inhibitor). Furthermore, we show that combined treatment of OC CPR spheroids with DCLK1 inhibitor (DCLK1-IN-1) and glutamine antagonist (DRP-104) showed a synergistic cytotoxic effect. In addition, the novel combination strategy was significantly effective in reducing OC cell adhesion and mesothelial cell clearance relative to single agent alone. Collectively, our findings establish DCLK1 as a key regulator of metastasis and demonstrate that its inhibition induces glutamine dependency in chemoresistant tumor cells. Thus, the combined use of DCLK1 inhibitors (e.g., DCLK1-IN-1) with glutamine metabolism inhibitors (e.g., DRP-104) represents a rational therapeutic approach to mitigate peritoneal metastases in a chemoresistant setting. Citation Format: Samrita Dogra, Cole Hladik, Sugantha Priya Elayapillai, Bethany Hannafon. Targeting DCLK1-mediated glutamine addiction in chemoresistant ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6647.

Topic: Cancer, Hypoxia, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences