jimnoneill/paper-to-field-training huggingface dataset:
Extraskeletal Myxoid Chondrosarcoma: State of the Art and Current Research on Biology and Clinical Management

Extraskeletal myxoid chondrosarcoma (EMC) is an ultra-rare mesenchymal neoplasm with uncertain differentiation, which arises mostly in the deep soft tissue of proximal extremities and limb girdles. EMC is marked by a translocation involving the NR4A3 gene, which can be fused in-frame with different partners, most often EWSR1 or TAF1. Although EMC biology is still poorly defined, recent studies have started shedding light on the specific contribution of NR4A3 chimeric proteins to EMC pathogenesis and clinical outcome. Standard treatment for localized disease is surgery, plus or minus radiation therapy with an expected prolonged survival even though the risk of relapse is about 50%. In advanced cases, besides the standard chemotherapy currently used for soft tissue sarcoma, antiangiogenic agents have recently shown promising activity. The aim of this review is to provide the state of the art of treatment for localized and advanced disease, with a focus on pharmacological treatments available for EMC. The biological basis of current research and future perspectives will be also discussed.

Topic: Bone Tumor Diagnosis and Treatments
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Improvement for Hydraulic Support with Valve Comprehensive Performance Test Rig Hydraulic System

Hydraulic valve for comprehensive performance test rig with hydraulic system is improved and perfected.According to traditional hydraulic support operating valve test rig not setting forth relevant standards for integrated circuit,and test content not conforming with relevant standards,so test rig can only test for several foundation.Design of new test rig hydraulic system is introduced,make test rig can of hydraulic support with valves to big flow experiment.Compared with original test rig hydraulic system structure is simple,test results are reliable

Topic: Iterative Learning Control Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
The Western Australia Olfactory Memory Test: Reliability and Validity in a Sample of Older Adults

Abstract Objective The Western Australia Olfactory Memory Test (WAOMT) is a newly developed test designed to meet a need for a comprehensive measure of olfactory episodic memory (OEM) for clinical and research applications. Method This study aimed to establish the psychometric properties of the WAOMT in a sample of 209 community-dwelling older adults. An independent sample of 27 test-naïve participants were recruited to assess test retest reliability (between 7 and 28 days). Scale psychometric properties were examined using item response theory methods, combined samples (final N = 241). Convergent validity was assessed by comparing performance on the WAOMT with a comprehensive neuropsychological battery of domains (verbal and visual episodic memory, and odor identification), as well as other neuropsychological skills. Based on previous literature, it was predicted that the WAOMT would be positively correlated with conceptually similar cognitive domains. Results The WAOMT is a psychometrically sound test with adequate reliability properties and demonstrated convergent validity with tests of verbal and episodic memory and smell identification. Patterns of performance highlight learning and memory characteristics unique to OEM (e.g., learning curves, cued and free recall). Conclusion Clinical and research implications include streamlining future versions of the WAOMT to ease patient and administrative burden, and the potential to reliably detect early neuropathological changes in healthy older adults with nonimpaired OEM abilities.

Topic: Olfactory and Sensory Function Studies
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Female perception of copulatory courtship by male titillators in a bushcricket

Males of the bushcricket Metrioptera roeselii bear paired titillators that are spiny genital structures supposedly functioning as copulatory courtship devices. During copulation, the male inserts its titillators into the female's genital chamber, where they rhythmically tap on the sensilla-covered dorsal surface of the genital fold. Here, we investigated the stimulatory function of male titillators during mating in M. roeselii . Tracer backfills of presumptive mechanosensory sensilla at the female genital fold revealed a thick bundle of sensory axons entering the last unfused abdominal ganglion (AG-7). Electrophysiological recordings of abdominal nerves demonstrated that females sense mechanical stimulation at their genital fold. The mechanosensory responses, however, were largely reduced by the insecticide pymetrozine that selectively blocks scolopidia of internal chordotonal organs but not campaniform and hair sensilla on the outer cuticle surface. In mating experiments, the females showed resistance behaviours towards males with asymmetrically shortened titillators, but the resistance was largely reduced when mechanoreceptors at the female's genital fold were either pharmacologically silenced by pymetrozine or mechanically blocked by capping with UV-hardened glue. Our findings support the hypothesis that the male titillators in these bushcrickets may serve as copulatory courtship devices to mechanically stimulate the female genitalia to reduce resistance behaviour.

Topic: Animal Behavior and Reproduction
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Effect of Moringa Leaf Extract and its Solution Application Forms on Growth and Yield of Okra

Specieesculentus and family Malvaceae.It is locally known as Bhindi.Among different vegetables okra is one of the oldest vegetable that is grown around the globe.Okra originated in the hotter regions of Africa and is still grown in Mediterranean basin.At present,

Topic: Moringa oleifera research and applications
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Factors Affecting the Readiness of Malaysian Schools toward ICT Management: A Theoretical Context

ICT is now widely adopted within the education system in Malaysia. As such, teachers are now required to integrate ICT into their teaching and learning practices. The integration of ICT requires organizational change and adequate supports from schools to create an ICT culture. However, underutilization of ICT elicits the issue of the lack of ICT management readiness in schools. This paper aims to analyze the possible factors of ICT management readiness. A number of relevant studies have been discussed in this paper. A few propositions and a theoretical framework for ICT management readiness are recommended for the attention of school principals.

Topic: Gender and Technology in Education
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Clinical Significance of Marginal Zinc Deficiency as a Predictor of Covert Hepatic Encephalopathy in Patients with Liver Cirrhosis

Covert hepatic encephalopathy (CHE) can worsen the quality of life and prognosis of patients with cirrhosis. We analyzed the risk factors of CHE and identified patients at high risk for overt hepatic encephalopathy (HE) who would benefit from therapeutic interventions. We included 145 patients without a history of or treatment for overt HE. Patients were divided into the CHE and no-CHE groups (n = 91 and 54, respectively). CHE had a score above the age-based cutoff value of one of the neuropsychological tests, such as the Stroop and number connection tests. CHE prevalence was 62.8% (n = 91). Compared with the no-CHE group, the CHE group had significantly lower serum zinc and albumin levels. Multiple logistic regression analysis identified serum zinc levels at a cutoff value of 74 µg/dL. Subclinical zinc deficiency showed a diagnostic performance of 55.6% sensitivity and 81.5% specificity for CHE. Blood ammonia levels and liver functional reserves were not predictive of CHE. Compared with patients with zinc levels &lt; 74 µg/dL (n = 102), those with ≥74 µg/dL (n = 43) had significantly lower CHE prevalence and better hepatic functional reserve. Subclinical zinc deficiency was associated with CHE occurrence in patients with cirrhosis without a history of or treatment for overt HE. Measurement of zinc levels facilitates early detection of CHE by neuropsychological testing.

Topic: Liver Disease and Transplantation
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
BCL-6 mutations in normal germinal center B cells: Evidence of\nsomatic hypermutation acting outside Ig loci

The molecular mechanism involved in the process of antigen-driven\nsomatic hypermutation of Ig genes is unknown, but it is commonly\nbelieved that this mechanism is restricted to the Ig loci. B cell\nlymphomas commonly display multiple somatic mutations clustering in the\n5′-regulatory region of BCL-6, a proto-oncogene encoding for a\nPOZ/Zinc finger transcriptional repressor expressed in germinal\ncenter (GC) B cells and required for GC formation. To determine whether\nBCL-6 mutations represent a tumor-associated phenomenon or reflect a\nphysiologic mechanism, we screened single human tonsillar GC B cells\nfor mutations occurring in the BCL-6 5′-noncoding region and in the Ig\nvariable heavy chain sequences. Thirty percent of GC B cells, but not\nnaive B cells, displayed mutations in the 742 bp region analyzed within\nthe first intron of BCL-6 (overall frequency: 5 ×\n10−4/bp). Accordingly, an expanded survey in lymphoid\nmalignancies showed that BCL-6 mutations are restricted to B cell\ntumors displaying GC or post-GC phenotype and carrying mutated Ig\nvariable heavy chain sequences. These results indicate that the somatic\nhypermutation mechanism active in GC B cells physiologically targets\nnon-Ig sequences.

Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Contribution to the flora of Greece: a new species of<i>Arundo (Poaceae)</i>

Danin, A., Raus, Th. & Scholz, H.: Contribution to the flora of Greece: a new species of Arundo (Poaceae). — Willdenowia 32: 191–194. 2002. — ISSN 0511-9618.The new species Arundo hellenica is described from Greece. It is related to A. plinii but differs in smaller size of all morphological structures and in the configuration of the lemma, which, below the awn, is entire at the apex, not bifid as usually in the genus Arundo. The new species, probably a Greek endemic strongly confined to disturbed habitats, behaves as an aggressive weed and may become invasive in other countries.

Topic: Plant Taxonomy and Phylogenetics
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The Effects of Modes on Text Editing by Experienced Editor Users

Experienced nonclerical users of two screen editors, vi and emacs, were asked to do a series of editing and composition tasks. The results suggest that moded editing, as exemplified by the vi editor, may be preferable far fixed editing tasks, whereas modeless editing, as exemplified by the emacs editor, may have some advantages during composing. The vi subjects left fewer errors in their final files and showed a tendency to do the editing tasks faster, though the time differences may have resulted from differences in typing rates. They made few mode errors, and those few were rapidly and easily corrected. The emacs subjects tended to do more of their editing during the first-draft stage of composing than did the vi subjects; this result agrees with the hypothesis that modeless editing is more flexible than moded editing. However, the total editing done while composing, the composing time, and most writing-style variables were similar far the two groups.

Topic: Software Engineering Research
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
In vivo Molecular Labeling of Halogenated Volatile Anesthetics using Adaptively Phase-modulated Femtosecond Pulses

We determined the low-frequency vibrational modes of sevoflurane and isoflurane, two of the most representative volatile anesthetics, by anti-Stokes Raman scattering (CARS) microscopy using adaptively phase-modulated femtosecond pulses. These modes were found to be associated with multiple halogen atoms. Because halogen atoms rarely appear in biological compounds, the entire spectral landscape of these modes is possibly a good marker for investigating the spatial localization of these drugs within the intracellular environment. We detected the unique CARS signal of sevoflurane for the first time in a live squid giant axon.

Topic: Spectroscopy Techniques in Biomedical and Chemical Research
Subfield: Biophysics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supplementary Table 2 from The Stem Cell Factor &lt;i&gt;HMGA2&lt;/i&gt; Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites

&lt;p&gt;Cox regression models for overall, tumor-specific and progression-free survival time (only HPV-negative cases)&lt;/p&gt;

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
PHENOMICS IN ABIOTIC STRESS MANAGEMENT

Several abiotic stresses resulting from increased population, global warming, and other possible climatic conditions have affected the development and production of several agriculturally essential crops. Drought, flood, salinity, high temperature, and other abiotic stressors affect plant physiology as well as its appearance which can occasionally result in a famine-like condition. In this context, plant breeders have a difficult problem in developing climate-resilient varieties: understanding the crops reaction to various stress situations and the underlying stress resistance processes. Over the last decade, advances in molecular tools and functional genomics have made the process of cloning and characterization of essential genes much easier that driving abiotic stress traits. To fully assess a genotype's potential under stress, however, phenotypic behaviour must be evaluated, as well as the components that coordinate such reactions. As a result, in this post-genomic age, sophisticated phenotyping technologies are required for optimal use of the huge amount of genetic data in climate-resilient breeding. Advanced phenomics devices measure shoot and root development, chlorophyll content, canopy temp, and other morphological features of plants in response to various abiotic stimuli with a high degree of precision and in a short amount of time. As a result, phenomics is an important tool for narrowing the gap between genotyping and phenotyping, and it is highly advisable for addressing climate change.

Topic: Genetic Mapping and Diversity in Plants and Animals
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Ictus isquémico recurrente criptogénico

Ictus isquémico recurrente criptogénicoDescargar caso en PDFEnviar caso a un amigoRevista Neurorecordings: 2022 - Vol: 4 Num: 1 | ISSN: 2386-8031Mujer | 58 añosDiagnóstico final: Carotid web (displasia fibromuscular atípica)Nivel de certeza: Neurología: Patología cerebrovascularEtiología: IctusBelén Baena Álvarez - Hospital Universitario Ramón Y CajalSebastián García Madrona23-Jun-2021 doi: 10.26429/nr-5973 Resumen del casoMujer de 58 años que acude a nuestro centro por cuadro de torpeza de la mano izquierda y disartria de 10 min de duración. A nuestra valoración la paciente se encontraba neurológicamente asintomática con TA...

Topic: Renal and Vascular Pathologies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
TO REPORT A CASE OF UNILATERAL PAPILLITIS IN A YOUNG FEMALE

Objectives: The purpose of the study is to report a case of unilateral papillitis in a young female. Methods: A 13-year-old girl presented in our outpatient department with sudden, painful, and progressive diminution of vision in the left eye for the past 7 days. The best-corrected visual acuity in R/E was 6/6 and in L/E was FC 5 m. On slit-lamp examination of the anterior segment, RAPD was present in L/E and rest findings were within normal limits. Fundus examination of R/E was within normal limits and of L/E – blurred disc margin, elevated disc, hyperemic disc, flame-shaped hemorrhages along superior arcuate vessels, retinal vessels were tortuous and foveal reflex was present. The case was evaluated with optical coherence tomography, Goldmann applanation tonometer, and color vision test (Ishihara test). Ocular movements were at full range. Results: Retinal imaging of L/E showed blurred disc margin, elevated disc, hyperemic disc, flame-shaped hemorrhages, tortuous retinal vessels, and foveal reflex present and of R/E, CD ratio – 0.3, retinal vessels – normal, and foveal reflex – present. Intraocular pressure on Goldmann applanation tonometer was 16 mmHg in R/E and 18 mmHg in L/E. A color vision test showed severely impaired color vision in her L/E. Conclusion: Papillitis refers to the involvement of the optic disc in inflammatory and demyelinating disorders of the optic nerve. The patient was counseled regarding the nature of lesion and rare incidence of complications such as postneuritic optic atrophy leading to complete blindness in case of a recurrent attack of papillitis. Optic neuritis treatment trial was started and significant improvement in visual acuity and fundus findings were seen.

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Data from Overcoming Cancer Immune Tolerance and Escape

&lt;div&gt;Abstract&lt;p&gt;Although HER2/neu–targeted cancer vaccines have shown initial promise in the adjuvant setting, a therapeutic vaccine remains elusive due to the tumor escape mechanisms of established cancer. As described by Seavey et al. in this issue of CCR, a &lt;i&gt;Listeria&lt;/i&gt;-delivered vaccine may help overcome immune tolerance, leading to an effective therapeutic vaccine.&lt;/p&gt;&lt;/div&gt;

Topic: Immunotherapy and Immune Responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
A New Non-Isolated Buck-Boost Converter with High Voltage Gain and Positive Output Voltage for Renewable Energy Applications

In this paper, a new buck-boost dc-dc converter, which is applicable to renewable energy sources, is proposed. The proposed converter is capable of delivering the desired output voltage over a wide range of input voltage variations. Depending on the load requirements, by changing the duty cycle of the switches, the proposed converter can operate as a buck-boost converter. In this converter, the output voltage polarity is the same with the input voltage polarity, and the input has a common ground with the output. The voltage gain of the proposed converter is high compared to similar structures. The proposed converter is thoroughly analysed under CCM operation and simulated in the PSCAD/EMTDC software environment to confirm the mathematical analysis.

Topic: Advanced DC-DC Converters
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
In Search of a New Cognitive Schema: Unsettling Colonial Epistemologies in Dionne Brand’s A Map to the Door of No Return

In this paper, I argue that Dionne Brand’s A Map to the Door of No Return: Notes to Belonging unsettles the epistemic foundations of the (Post-)Colonial Anthropocene, which prioritize linearity, binarity, and purported objectivity. Dominant contemporary epistemologies, as Sylvia Wynter has demonstrated, race and gender legitimate knowledge production as the preserve of Man, to the exclusion of human and non-human others. Instead, writing towards the multipolarity and -modality of the Door of No Return, Brand posits and practices, through both form and content, an anti-colonial epistemology, in which temporality and spatiality are recursive and knowledge is embodied and pluriversal.

Topic: Ecocriticism and Environmental Literature
Subfield: Literature and Literary Theory
Field: Arts and Humanities
Domain: Social Sciences
Alternative approaches to K-12 school technology illustrated by an experimental course in technical investigations

School technology programmes in the western world are being pursued through the age ranges 5-15/16 and 11-15/16 and in some countries they are compulsory. Information technology is likely to be a cross curricular activity. The objectives and content of such programmes may differ considerably from the objectives that engineers might believe they should have. The term technology is broadly interpreted, as in every day life, and there is no specific focus on engineering. Given that they are based on design and make activities they respond to neglected areas of the curriculum, i.e. the provision of practical work, the tapping of spatial ability and creative talent, and the development of problem-solving skills. Such aims contribute to the completion of a child's general education and there the matter should rest. Among the criticisms that have been levelled against these programmes are that they pay inadequate attention to the role of science in technological development. However, it may be objected that students would, in any event, be more able to cope with an engineering oriented curriculum in senior high school (i.e. post 15/16).

Topic: Science Education and Pedagogy
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Here comes the flood! Stress effects of continuous and interval waterlogging periods during the growing season on Scots pine saplings

Abstract Future climate scenarios for the boreal zone project increasing temperatures and precipitation, as well as extreme weather events such as heavy rain during the growing season. This can result in more frequent short-term waterlogging (WL) leading to unfavorable conditions for tree roots. In addition, it is decisive whether short-term WL periods during the growing season occur continuously or periodically. We assessed the effects of short-termed WL on 4-year-old Scots pine (Pinus sylvestris L.) saplings after shoot elongation started. Waterlogging (WL) lasted either continuously for 2.5 weeks (ContWL) or noncontinuously for 5 weeks, consisting of three repeated 1-week-interval WL periods (IntWL). Both treatments resulted in the same duration of soil anoxia. We studied soil gases, root and shoot growth and physiology, and root survival probability and longevity during the experiment. In the final harvest, we determined shoot and root biomass and hydraulic conductance and electrical impedance spectra of the root systems. Soil CO2 and CH4 concentrations increased immediately after WL onset and O2 decreased until anoxia. Waterlogging decreased fine root survival probability, but there was no difference between WL treatments. Shoot growth suffered more from ContWL and root growth more from IntWL. Needle concentrations of pinitol increased in the WL saplings, indicating stress. No WL effects were observed in photosynthesis and chlorophyll fluorescence. Increased starch concentration in needles by WL may be due to damaged roots and thus a missing belowground sink. Electrical impedance indicated suffering of WL saplings, although root hydraulic conductance did not differ between the treatments. Oxidative stress of short-term and interval WL can have long-lasting effects on shoot and root growth and the physiology of Scots pine. We conclude that even short-term WL during the growing season is a stress factor, which will probably increase in the future and can affect carbon allocation and dynamics in boreal forests.

Topic: Plant responses to water stress
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences