jimnoneill/paper-to-field-training huggingface dataset:
A new species of Macrotarsomys (Rodentia: Muridae: Nesomyinae) from southwestern Madagascar

ABSTRACT A new species of Macrotarsomys, M. petteri (Rodentia: Muridae: Nesomyinae), is described based on a single specimen taken during a 2003 biological survey of the Forêt des Mikea in southwestern Madagascar. This is the third species known in this endemic genus, and all are confined to the dry forest formations of western Madagascar. The region where M. petteri occurs is a unique transitional forest habitat that is under considerable threat from human-induced habitat degradation and steps need to be swiftly taken to protect the Forêt des Mikea.

Topic: Animal Ecology and Behavior Studies
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Network pharmacology exploration to reveal molecular insights of Phyllanthus niruri in non-alcoholic fatty liver: In vitro and in silico evidence

The hepatic manifestation of metabolic syndrome, associated with various metabolic diseases such as type 2 diabetes, insulin resistance, and high cholesterol, is called non-alcoholic fatty liver disease (NAFLD). Despite several research efforts, no approved medicine is currently available for the treatment of this illness. Swiss Target Prediction was used to screen phytochemicals. To examine potential targets, the protein-protein interaction (PPI) network was developed. Cytoscape was used to create the component-target-pathway (C-T-P) network, and AutoDock was used to assess molecular docking. Antioxidant and anti-inflammatory qualities were tested in vitro . Naringenin, ellagic acid, and cyanidin were found to be the main active components. As important targets, PPARA, PPARG, and AKT1 were selected. Through enrichment analysis, a total of 20 crucial signaling pathways, including insulin resistance (IR), NAFLD, relaxin, PI3K-Akt, HIF-1, AGE-RAGE, and MAPK, were identified. The in silico computational techniques predicted the molecular pathway for the active ingredients and the disease targets, thus helping to further research.

Topic: Phytochemistry and Bioactivity Studies
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Predicting Postoperative Complications and Long-Term Survival After Lung Cancer Surgery Using Eurolung Risk Score

Stratification based on the parsimonious Eurolung scoring system showed good discriminatory ability for predicting postoperative morbidity, mortality, and long-term survival in South Korean patients with surgically resected non-small cell lung cancer. This might help clinicians to provide a detailed prognosis and decide the appropriate treatment option for high-risk patients with non-small cell lung cancer.

Topic: Lung Cancer Diagnosis and Treatment
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Identifying rodent olfactory bulb structures with micro-DTI

Olfactory bulb (OB) is one of the most developed systems in rodent models with complex neuronal organization and anatomical structures. MR diffusion tensor imaging (DTI) is a non-invasive technique to probe tissue microstructures by examining the diffusion characteristics of water molecules. This paper presents how different OB layers can be identified and quantitatively characterized by micro-DTI using a specially constructed micro-imaging radio frequency (RF) coil. High spatial resolution and high signal to noise ratio (SNR) DTI images of ex vivo rat OBs were obtained. Distinct contrasts were observed between various olfactory bulb layers in trace map, fractional anisotropy (FA) map and FA color map, all in consistency with the known OB neuroanatomy. These experimental results demonstrate the utility of micro-DTI in investigation of complex OB organization.

Topic: Olfactory and Sensory Function Studies
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Mathematical Solutions for Solving Periodic Railway Transportation

Train scheduling has been a significant issue in the railway industry. Over the last few years, numerous approaches and tools have been developed to compute railway scheduling. In this paper, we present a set of heuristics for a constraint‐based train scheduling tool, which is a project in collaboration with the National Network of Spanish Railways (RENFE), Spain. We formulate train scheduling as constraint optimization problems. Three heuristics are developed to speed up and direct the search toward suboptimal solutions in periodic train scheduling problems. The feasibility of our problem‐oriented heuristics is confirmed with experimentation using real‐life data. The results show that these techniques enable MIP solvers such as LINGO and ILOG Concert Technology (CPLEX) to terminate earlier with good solutions.

Topic: Railway Systems and Energy Efficiency
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
КІНОТУРИЗМ ЯК ІННОВАЦІЙНИЙ ІНСТРУМЕНТ РОЗВИТКУ СФЕРИ ГОСТИННОСТІ УКРАЇНИ

The film industry, as part of the creative industry, is designed itself to generate certain emotions of the consumer, which, in fact, push the consumer of a particular film product to further steps - to organize a trip to places you see or hear while watching films, programs, etc. This study is devoted to the development trends of cinema tourism and related hospitality. The purpose of the study: analysis of the level of cinema tourism in the world and in Ukraine, taking into account the available natural, historical and cultural resources that will be used for domestic cinema tourism, and will be the basis for creating new tourist routes and hospitality enterprises for various tourists, as well as for the east of the country. Research methods: in the process of scientific work were used general and special methods of scientific abstraction, induction and deduction, statistical analysis, analogy and quantitative and qualitative comparison. Research hypothesis: it is assumed that the development of cinema tourism and related hospitality enterprises as components of the tourism industry in the regions of Ukraine should be based on a set of theoretical principles, historical background and current socio-economic circumstances of each region. Research results: The review of theoretical aspects and historical facts of cinema tourism development allowed to clarify its definition and supplement the existing classification of its types. Analysis of cinema tourism development trends in Ukraine shows that, despite the already interesting film products, thorough historical and cultural heritage and infrastructural resources of the hospitality industry, the country is only taking the first steps towards implementing this innovative tool for tourism and hospitality. Owners of hospitality establishments in the regions that are popularized in modern Ukrainian cinema and television programs already have a significant benefit. Conclusions and prospects for further research: The eastern regions of Ukraine, being in a depressed state, need new tools for development. cinema tourism has every chance to become a catalyst that will help restore abandoned areas and sites of historical and cultural heritage, infrastructure and hospitality enterprises, identify alternative ways to develop them and create new tourist magnets.

Topic: Global Healthcare and Medical Tourism
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
LIVER CIRRHOSIS FROM AUTOIMMUNE HEPATITIS IN A NIGERIAN WOMAN: A CASE REPORT.

Autoimmune hepatitis (AIH) is a rare cause of chronic liver disease (CLD). It presents with varied clinical features from acute hepatitis to CLDs like chronic viral hepatitis and alcoholic liver disease, making it difficult to diagnose in the absence of a high index of suspicion and adequate laboratory support. Autoantibody-mediated hepatocyte injury is the major feature of AIH. We present a 44 year old woman with recurrent jaundice, ascites, splenomegaly, coagulopathy, negative chronic viral hepatitis screening, elevated IgG and positive anti-smooth muscle antibody. The patient responded well to immunosuppressive therapy. This report brings to the fore the need for physicians to maintain a high index of suspicion and thoroughly evaluate all CLD cases of seemingly 'unknown' etiology for AIH in order to prevent progression to end-stageliver- disease, since the disease is highly amenable to immunosuppressive therapy.

Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Fibroma and giant-cell tumor of tendon sheath: a case report

Abstract: A 53-year-old man presented in 2009 with a tumor over the dorsum of his hand and wrist. Magnetic resonance imaging was performed before surgery and histopathological and immunohistochemical studies were performed after surgery. This demonstrated an ill-defined lesion measuring 46 mm × 31 mm confined to the subcutaneous tissues, extensor tendons, and articular capsule on the dorsum of the hand and wrist with heterogeneous intermediate and high T1 and T2 signal suggesting a complex mixture of fat and fibrous elements. A histopathological differential diagnosis of hemosiderotic fibrohistiocytic lipomatous lesion/tumor (HFLL/T) and giant-cell tumor of tendon sheath and fibroma of tendon sheath was made. We describe this rare lesion and call attention to important points in diagnosis. Keywords: giant cell tumor, fibroma tumor, sheath tendon tumor

Topic: Musculoskeletal synovial abnormalities and treatments
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Sampled populations of &lt;i&gt;Cattleya liliputana&lt;/i&gt; occurring in the Iron Quadrangle.

&lt;p&gt;(a) Espinhaço Range Region above 1,000 m a.s.l. in eastern tropical South America. (b) Altitude map of the Iron Quadrangle showing the &lt;i&gt;Cattleya liliputana&lt;/i&gt; populations analysed in the study.&lt;/p&gt;

Topic: CRISPR and Genetic Engineering
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Michel Foucault, Postmodernity, Nietzsche, and Buddhism

Abstract: This paper introduces some strands of thought that may account for Foucault thinking along the lines of post-modernity: existential concern with his homosexuality, Nietzschean ideas on transvaluing and overcoming of ressentiment, interest in Zen Buddhism and process thought, and an openness to cultural history and non-linear thinking.

Topic: Foucault, Power, and Ethics
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Abstract 19252: Ideal Cardiovascular Health and Employee Productivity

Introduction: The AHA has defined ideal cardiovascular health (CVH) as the simultaneous presence of 4 optimal health behaviors (not smoking, eating a healthy diet, meeting physical activity goals, and maintaining a healthy weight) and 3 optimal health factors (lower blood pressure, blood sugar, and cholesterol). An association between ideal CVH and employee productivity has not yet been established. Objectives: In this study, we sought to investigate whether employees with high CVH are more productive than employees with moderate or low CVH. Methods: In fiscal year 2015, an academic medical center offered health risk appraisal surveys (HRAs) to its 6,500 employees. Completion rates have been &gt;90% to date (n=6,144). Ideal, intermediate, and poor levels for each of the 7 components listed above were calculated from HRA responses according to standard AHA definitions and assigned values of 2, 1, and 0 respectively. An overall CVH score was calculated for each respondent from the sum of individual component scores with a range of 0-14 (low 0-7 points, moderate 8-10, and high 11-14). Productivity was measured by responses related to missed work days due to illness (absenteeism) and days employees came to work but did not feel at their best (presenteeism). In this cross-sectional analysis, we used logistic regression to compare productivity responses between employees with high, moderate, and low CVH adjusting for race and sex (age was unavailable due to employee privacy concerns). Results: Overall, 35% of employees were in high CVH, 58% moderate, and 6% low. The odds of missing at least one workday due to illness during a two-week period were 67% lower among employees with high CVH compared to employees with low CVH (adjusted OR 0.33; 95% CI, 0.20-0.56). The odds of reporting that physical or emotional health problems made it difficult to concentrate on work at least half the time were 85% lower among employees with high CVH compared with low CVH (adjusted OR 0.15; 95% CI, 0.07-0.33). Conclusions: Self-reported higher CVH was strongly associated with better employee productivity as measured by fewer sick days and better concentration at work. These results support the notion that helping employees stay healthy may represent a valuable near-term strategy for employers.

Topic: Cardiovascular Health and Risk Factors
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Characterization of a reverse molding sequence at the mesoscale for in‐mold assembly of revolute joints

Abstract In‐mold assembly and miniature molding have been combined to realize miniature assemblies. Our previous work has shown that for realizing in‐mold assembly at the mesoscale, the molding sequence is the reverse of that used at the macroscale. Moreover, special features are needed in the mold to prevent plastic bending of the pin because of the pressure exerted by the second stage melt. This article presents novel mold designs and computational methods to enable the use of the reverse molding sequence to prevent: (1) plastic bending of the premolded component, and (2) joint jamming during the mesoscale in‐mold assembly process. The computational methods are also validated through experimentation. Results reported in this article show that for making in‐mold assembled revolute joints with the polymer combination of ABS and LDPE, a reversed molding sequence needs to be used for joints sizes less than 1.5 mm. POLYM. ENG. SCI., 50:1843–1852, 2010. © 2010 Society of Plastics Engineers

Topic: Injection Molding Process and Properties
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Pathogenic germline variants in patients with early-onset colorectal cancer according to phenotype.

<title>Abstract</title> We assessed retrospectively the prevalence of pathogenic germline variants (PGVs) in 271 French adult patients diagnosed with colorectal cancer (CRC) before age 41, stratified by phenotype. <italic>APC, BMPR1A, CDH1, EPCAM, MLH1, MSH2, MSH3, MSH6, MUTYH, POLE, POLD1, PTEN, PMS2, SMAD4,</italic> and <italic>STK11</italic>were analysed. Overall, 21.4% of cases carried a PGV. A high prevalence was observed in Mismatch Repair-deficient (MMRd) CRC (59.7%, <italic>MMR</italic> genes) and CRC associated with polyposis (48%, <italic>APC</italic>, biallelic <italic>MUTYH</italic> and <italic>MSH3</italic>, <italic>POLE</italic>). In contrast, MMR-proficient, non-polyposis cases only had a 1.7% prevalence. The only gene involved in this third group was <italic>POLE</italic>, and two out of three cases had either two synchronous CRC or a CRC family history. PGV prevalence is dependent on CRC phenotype, questioning the need for systematic germline testing in early-onset cases. A more targeted approach, focusing on MMRd CRC, or CRC associated with polyposis, might be warranted.

Topic: Genetic factors in colorectal cancer
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Relationship of Histology to Prognosis in Thyroid Carcinoma

Prognosis in carcinoma of the thyroid varies more widely and consistently with the histologic pattern than perhaps any other neoplasm. This fact has been observed particularly in relation to the papillary forms, which have a good although not necessarily an excellent prognosis. The follicular form is associated with only a fair prognosis, and the anaplastic forms are invariably rapidly fatal. A major proportion of the differentiated carcinomas of the thyroid exhibit a mixed pattern of both papillary and follicular elements. The clinical implications of the respective roles of these two components in the mixed forms have not been emphasized by most studies of thyroid cancer. The usual classifications do not recognize the mixed forms as such, assigning given tumors to either papillary or follicular categories according to predominant cell type. In an effort to evaluate the clinical significance of predominance of either the papillary or follicular elements in the mixed

Topic: Thyroid Cancer Diagnosis and Treatment
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Clinical Significance of Morphological Inspection in the Early Diagnosis of Ocular Surface Infective Disease

Objective By Morphological examination,as soon as possible to understand the infective status.To help physician to indentify the species of infection before microorganisms culture results.Methods 2009,our hospital out-patient hospital and some ocular diseases were 151 separate specimens,while for bacterial smear and culture,fungal smear and culture,special specimens do amoeba under your doctor or chlamydia smears.Results Of 151 samples,88 cases of smear-positive specimens,the positive rate was 58.3%.Of which 48 cases of smear-positive bacteria,the positive rate of 31.8%,fungal smear positive in 51 cases,the positive rate of 33.8%.Bacterial smear-positive rate(31.8%) and bacterial culture was positive(28.5%) had no significant difference.Fungal smear positive rate(33.8%) and fungal culture was positive(25.8%) significant difference between.Conclusion Smears in early diagnosis of ocular surface disease plays a very important role,it can help a doctor as soon as possible to understand infectious pathogens,early medical guide rational drug use.

Topic: Ocular Surface and Contact Lens
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Peer Review #1 of "Construction and validation of an RNA-binding protein-associated prognostic model for colorectal cancer (v0.1)"

Colorectal cancer (CRC) is one of the most prevalent and fatal malignancies, and novel biomarkers for the diagnosis and prognosis of CRC must be identified.RNA-binding proteins (RBPs) are essential modulators of transcription and translation.They are frequently dysregulated in various cancers and are related to tumorigenesis and development.The mechanisms by which RBPs regulate CRC progression are poorly understood and no clinical prognostic model using RBPs has been reported in CRC.We sought to identify the hub prognosis-related RBPs and to construct a prognostic model for clinical use.mRNA sequencing and clinical data for CRC were obtained from The Cancer Genome Atlas database (TCGA).Gene expression profiles were analyzed to identify differentially expressed RBPs using R and Perl software.Hub RBPs were filtered out using univariate Cox and multivariate Cox regression analysis.We used functional enrichment analysis, including Gene Ontology and Gene Set Enrichment Analysis, to perform the function and mechanisms of the identified RBPs.The nomogram predicted overall survival (OS).Calibration curves were used to evaluate the consistency between the predicted and actual survival rate, the consistency index (c-index) was calculated, and the prognostic effect of the model was evaluated.Finally, we identified 178 differently expressed RBPs, including 121 up-regulated and 57 down-regulated proteins.Our prognostic model was based on nine RBPs (PNLDC1, RRS1, HEXIM1, PPARGC1A, PPARGC1B, BRCA1, CELF4, AEN, and NOVA1).Survival analysis showed that patients in the high-risk subgroup had a worse OS than those in the low-risk subgroup.The area under the curve value of the receiver operating characteristic curve of the prognostic model is 0.712 in the TCGA cohort and 0.638 in the GEO cohort.These results show that the model has a moderate diagnostic ability.The c-index of the nomogram is 0.77 in the TCGA cohort and 0.73 in the GEO

Topic: RNA Research and Splicing
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Networks of Coordination: Swiss Business Associations as an Intermediary between Business, Politics and Administration during the 20<sup>th</sup>Century

Until the 1990's, Switzerland could be classified as either a corporatist, cooperative or coordinated market economy where non-market mechanisms of coordination among economic and political actors were very important. In this respect, Business Interest Associations (BIAs) played a key role. The aim of this paper is to look at the historical evolution of the five main peak Swiss BIAs through network analysis for five assorted dates during the 20th century (1910, 1937, 1957, 1980 and 2000) while relying on a database that includes more than 12,000 people. First, we examine the logic of membership in these associations, which allows us to analyze their position and function within the network of the Swiss economic elite. Until the 1980's, BIAs took part in the emergence and consolidation of a closely meshed national network, which declined during the two last decades of the 20th century. Second, we investigate the logic of influence of these associations by looking at the links they maintained with the political and administrative worlds through their links to the political parties and Parliament, and to the administration via the extra-parliamentary commissions (corporatist bodies). In both cases, the recent dynamic of globalization called into question the traditional role of BIAs.

Topic: Political Influence and Corporate Strategies
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Preparation of Sodium Deoxycholate (DOC) Conjugated Heparin Derivatives for Inhibition of Angiogenesis and Cancer Cell Growth

We describe new DOC (sodium deoxycholate)-heparin nanoparticles for in vivo tumor targeting and inhibition of angiogenesis based on chemical conjugation and the enhanced permeability and retention (EPR) effect. Heparin has been used as a potent anticoagulant agent for 70 years, and has recently been found to inhibit the activity of growth factors which stimulate the smooth muscle cells around tumor. From the results, DOC and heparin were conjugated by bonding carboxyl groups of heparin with amine groups of aminated sodium deoxycholate. Larger antitumor effects of the DOC-heparin VI (8.5 mol of DOC coupled with 1.0 mol heparin) were achieved in animal studies, compared to heparin alone. We confirmed that the conjugated heparin retained its ability to inhibit binding with angiogenic factor, showing a significant decrease in endothelial tubular formation. These results provide new insights into the nontoxic anticancer drug carrier as well as the design of multifunctional bioconjugates for targeted drug delivery.

Topic: Proteoglycans and glycosaminoglycans research
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Merly.jl: Web Framework in Julia

Merly.jl is a package for creating web applications in Julia. It presents features such as the creation of endpoints with function notation and with macro notation, handling of static files, use of path parameters, processing of data sent by a web client in the body in a personalized way, handling of CORS and compatibility with the use of middleware. It presents a familiar syntax with the rest of the most popular web frameworks without neglecting the execution performance. This manuscript mentions the operation and main features of Merly.jl

Topic: Service-Oriented Architecture and Web Services
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences