jimnoneill/paper-to-field-training huggingface dataset:
Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

Nineteen independently isolated hybridomas producing monoclonal antibodies to the glycoprotein of vesicular stomatitis virus were isolated and studied for their capacity to neutralize viral infectivity. By measuring competitive binding of 125I-labeled monoclonal antibodies in a radioimmunoassay. 11 different, non-cross-reacting antigenic determinants were identified on the vesicular stomatitis virus G protein. All monoclonal antibodies reacting with determinants 1, 2, 3, and 4 resulted in viral neutralization, whereas those binding to the other seven determinants did not neutralize infectivity. The mixture of two monoclonal antibodies binding to different determinants resulted in a more rapid neutralization than either antibody alone, suggesting that different antibodies can exert a synergistic effect on viral neutralization. Kinetic experiments revealed biphasic neutralization curves similar to those expected for heterologous antibody. No evidence could be obtained to relate biphasic kinetics of viral neutralization to heterogeneous populations either of antibody molecules or of virus. The possible significance of the kinetic data with monoclonal antibodies is discussed.

Topic: Parvovirus B19 Infection Studies
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Hybrid neurocomputing: the integration between the human brain and artificial intelligence for the next generation of neurotechnological interfaces

This article explores the concept of hybrid neurocomputing, focusing on the integration of the human brain with artificial intelligence systems for the development of next-generation neurotechnological interfaces. The study analyzes current advances in neurotechnology, artificial intelligence, and brain–computer interaction, highlighting their potential applications in healthcare, rehabilitation, and human–machine collaboration. The work emphasizes the relevance of hybrid neurocomputing for improving clinical outcomes, enhancing assistive technologies, and supporting innovation within the healthcare and biomedical engineering sectors. By addressing the convergence of neuroscience and artificial intelligence, this publication contributes to ongoing discussions on the future of neurotechnology and its implications for public health and technological advancement.

Topic: EEG and Brain-Computer Interfaces
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Desmopressin Reverses Overly Rapid Serum Sodium Correction in a Hyponatremic Patient Undergoing Living Donor Liver Transplantation: A Case Report

Patients with end-stage liver disease are often hyponatremic due to multiple physiological processes associated with hepatic failure. For severely hyponatremic patients undergoing liver transplantation, intraoperative management of serum sodium concentration ([Na] s ) is challenging. [Na] s tends to increase during transplantation by the administration of fluids with higher sodium concentration than the patient’s [Na] s . An overly rapid increase in [Na] s (&gt;1 mEq·L − 1 ·hour − 1 ) is difficult to avoid and increases the risk of serious perioperative complications. We report the successful use of intravenous desmopressin to reverse an overly rapid rise in [Na] s during living donor liver transplantation.

Topic: Electrolyte and hormonal disorders
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Conceptualization of Anger in Modern Standard Arabic and English: A Comparative Study

Figurative language is part of our everyday life where meaning is communicated indirectly. Metaphor is among the major figurative devices that are commonly encountered in interactions. The aim of this study is to investigate the use of metaphors to conceptualize abstract concepts namely that of anger in both English and Arabic. To this extent, a corpus consisting of metaphorical expressions denoting anger in both languages was utilized. These expressions were classified based on their metaphorical mappings and later on analysed using Kövecses’ (2002) framework. Results indicated that even though the two languages share a number of anger conceptualizations, they had certain differences. These differences were attributed to difference in language, in the sense that language genius and vocabulary repertoire often influence the conceptualization process. Culture, too, proved to be another source of as elements like climate and life style manipulate the conceptualization process. Note that the study of metaphorical conceptualization of emotions in general and anger specifically is underestimated in Arabic and further research is required

Topic: Language, Metaphor, and Cognition
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Perforation of the Nasal Septum and Nasal Ulcers

A case about a HIV woman with nasal ulcers is described in this paper. In every inmunodepressed patient who has mu-cosal or cutaneous ulcers, infection by leishmanial parasites needs to be ruled out, especially when ulcers have not re-gression with usual treatments. The Leishmanial nasal disease usually shows swelling and mucosal ulcers, that may progress to necrosis. Delaying in appropriate therapy might cause irreversible damage.

Topic: Research on Leishmaniasis Studies
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Oleanane Triterpenoids from Cedrela montana (Meliaceae)

Two new oleanane-type triterpenes, characterized as 3-oxo-11α,12α-epoxy-oleanan-28,13β- olide and 3-oxo-olean-11-en-28,13β-olide , were isolated from the fruits and seeds of Cedrela montana (Meliaceae). In addition, the known compounds oleanonic acid , a mixture of β-sitosterol and stigmasterol, and the limonoid photogedunin were also isolated. The structures of the new compounds were established by spectroscopic methods, including 2D NMR.

Topic: Phytochemical compounds biological activities
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
FEATURES OF THE TECHNOLOGICAL PROCESS OF MANUFACTURING SPACE-BASED MICROCHIPS USING CMOS KNS TECHNOLOGY

The article deals with the technological process of manufacturing CMOS integrated circuits on KNS (silicon on sapphire) structures for space purposes. The technology is based on an n-type CMOS process with one level of polysilicon and two levels of metal. The components of the technological process are analyzed. The sequence of the technological process and its features are given. An example of a description of one of the elements is considered.

Topic: Aerospace, Electronics, Mathematical Modeling
Subfield: Nature and Landscape Conservation
Field: Environmental Science
Domain: Physical Sciences
Removal of clock gene <i>Bmal1</i> from the retina affects retinal development and accelerates cone photoreceptor degeneration during aging

Significance Circadian rhythms are not simply a passive consequence of cyclic fluctuations in the environment, but instead originate within the organism. Accumulating evidence indicates that disruption of circadian rhythms contributes to the development of many diseases. Here, we demonstrate that removal of the clock gene Bmal1 from the retina has multiple effects on rod and cone pathways. In the cone pathway, the primary effect is on cone viability, an effect accentuated in aging mice. In the rod pathway, we observed that retinal Bmal1 removal caused stunting of rod bipolar cell dendrites and thinning of the outer plexiform layer in both young and old mice. Hence, our data suggest that circadian clock dysfunction contributes to aberrant visual function during development and aging.

Topic: Circadian rhythm and melatonin
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
NFO Process in Mutual Fund at India Infoline

The purpose of this project creates a design in relation to process of NFO (NEW FUND OFFER) and how this process is carried out till the end.The school work of this project is based on the procedure takes place in India Infoline while going through the NFO.To schoolwork the technical procedure, legal dimensions of NFO at India info line and examine briefly the organizational structure, communication network, resource, requirements to launch a new fund. The analysis is made by carrying the applications of reliance equity fundThe data for his study is colleted from various sources like magazines, Books, Websites, and from the staff of Indian Info Line.It generates an Idea to the investors in knowing the technical procedure in carrying a NFO by the Organization.

Topic: Private Equity and Venture Capital
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Altered Expression Pattern of Polycystin-2 in Acute and Chronic Renal Tubular Diseases

Polycystin-2 represents one of so far two proteins found to be mutated in patients with autosomal-dominant polycystic kidney disease. Evidence obtained from experiments carried out in cell lines and with native kidney tissue strongly suggests that polycystin-2 is located in the endoplasmic reticulum. In the kidney, polycystin-2 is highly expressed in cells of the distal and connecting tubules, where it is located in the basal compartment. It is not known whether the expression of polycystin-2 in the kidney changes or whether it can be manipulated under certain instances. Therefore, the distribution of polycystin-2 under conditions leading to acute and chronic renal failure was analyzed. During ischemic acute renal failure, which affects primarily the S3 segment of the proximal tubule, a pronounced upregulation of polycystin-2 and a predominantly combined homogeneous and punctate cytoplasmic distribution in damaged cells was observed. After thallium-induced acute injury to thick ascending limb cells, polycystin-2 staining assumed a chicken wire-like pattern in damaged cells. In the (cy/+) rat, a model for autosomal-dominant polycystic kidney disease in which cysts originate predominantly from the proximal tubule, polycystin-2 immunoreactivity was lost in some distal tubules. In kidneys from (pcy/pcy) mice, a model for autosomal-recessive polycystic kidney disease in which cyst formation primarily affects distal tubules and collecting ducts, a minor portion of cyst-lining cells cease to express polycystin-2, whereas in the remaining cells, polycystin-2 is retained in their basal compartment. Data show that the expression and cellular distribution of polycystin-2 in different kinds of renal injuries depends on the type of damage and on the nephron-specific response to the injury. After ischemia, polycystin-2 may be upregulated by the injured cells to protect themselves. It is unlikely that polycystin-2 plays a role in cyst formation in the (cy/+) rat and in the (pcy/pcy) mouse.

Topic: Genetic and Kidney Cyst Diseases
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Influences on birth spacing intentions and desired interventions among women who have experienced a poor obstetric outcome in Lilongwe Malawi: a qualitative study

Stillbirth and neonatal mortality are very high in many low-income countries, including Malawi. Use of family planning to encourage birth spacing may optimize outcomes for subsequent pregnancies. However, reproductive desires and influences on birth spacing preferences of women who have experienced a stillbirth or neonatal death in low-resource settings are not well understood.We conducted a qualitative study using 20 in-depth interviews and four focus group discussions with women who had experienced a stillborn baby or early neonatal death to explore attitudes surrounding birth spacing and potential interventions to promote family planning in this population. Qualitative data were analyzed for recurrent patterns and themes and central ideas were extracted to identify their core meanings.Forty-six women participated in the study. After experiencing a stillbirth or neonatal death, most women wanted to wait to become pregnant again but women with living children wished to wait for longer periods of time than those with no living children. Most women preferred birth spacing interventions led by clinical providers and inclusion of their spouses.Many influences on family size and birth spacing were noted in this population, with the most significant influencing factor being the spouse. Interventions to promote birth spacing and improve maternal and neonatal health in this population need to involve male partners and knowledgeable health care providers to be effective.Clinicaltrials.gov NCT02674542 Registered February 1, 2016 (retrospectively registered).

Topic: Global Maternal and Child Health
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Duplex DNA as a Self-Assembling Template for the Identification of Bidentate Protein-Binding Agents

This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 12°C increase in the melting temperature of the duplex in the presence of streptavidin.

Topic: Advanced biosensing and bioanalysis techniques
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Enthalpy and phase behavior of coal derived liquid mixtures. Technical progress report, January-March 1985

On July 15, 1984, work was initiated on a program to study the enthalpy and phase behavior of coal derived liquid model compound mixtures. During the third quarter modifications to both the calorimeter and the phase equilibria system were completed. The phase equilibria system was checked out against literature data for methanol/ethanol. Results of these tests are included in this report. The calorimeter was evaluated using previously confirmed heptane data and published data by Thinh, et al. These results are also reported. Initial calorimetry data have been obtained for tetralin and the data will be reported when the data set has been completed. 5 refs., 5 figs., 3 tabs.

Topic: Thermodynamic properties of mixtures
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
Functional outcomes and laryngectomy-free survival after transoral CO₂ laser microsurgery for stage 1 and 2 glottic carcinoma.

There is a higher likelihood of hoarseness after laser surgery, but the severity of this handicap is mild in most patients. Laser microsurgery results in excellent laryngeal preservation rates, which may exceed those of radiation.

Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Effects of self phase modulation of chirped pulses on compressed pulses

The pre-pulse duration and contrast are very important in the ultra-high power CPA laser system. The effects of the self phase modulation(SPM) were simulated on the peak intensity, pre-pulse duration and contrast of the compressed pulse, when the chirped pulse duration was 141 ps, the chirp coefficient was 1 000 and the B-integral value was 0, 1 or 2. The results show that when the B-integral value is 2, the SPM causes the peak intensity of the compressed pulse to decrease to 65%, and the pulse duration and pre-pulse duration to increase to 200 % and 300% respectively. When the B-integral ranges from 0.5 to 2, an approximate linear formulation can be used to describe the relationship between the pre-pulse duration and the B-integral value.

Topic: Laser Design and Applications
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The political engagement of women in post-conflict Kosovo

The Republic of Kosovo was created several years after the breakup of the Socialist Federal Republic of Yugoslavia. Its problems were visible during Josip Broz Tito’s presidency. Over the last ten years Kosovo has had two female presidents. The question is, what is the position of women on the Kosovan political scene? This phenomenon is particularly significant from the point of view of the post-conflict reconstruction of the state. The aim of this article is to analyse the evolution of the role of Kosovo Albanian women in the politics of Kosovo at the central level. For this reason, the article includes women involved in the armed conflict in Kosovo, especially in the activities of the Kosovo Liberation Army (KLA, alb. Ushtria Çlirimtare e Kosovës, UÇK). The author also presents the role of women in the Kosovan political arena since 1999, with particular emphasis on changes that took place after the declaration of independence of Kosovo. Furthermore, the author examines the profiles of selected female politicians. The article is based on an analysis of primary and secondary sources, the comparative and historical method, and an analysis of statistical data.

Topic: Balkans: History, Politics, Society
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Re: Estimating the Number of Vasectomies Performed Annually in the United States: Data From the National Survey of Family Growth

No AccessJournal of UrologyLetter to the Editor/Errata1 Apr 2011Re: Estimating the Number of Vasectomies Performed Annually in the United States: Data From the National Survey of Family GrowthM. L. Eisenberg and L. I. Lipshultz J Urol 2010; 184: 2068–2072 Michael L. Eisenberg and Larry I. Lipshultz Michael L. EisenbergMichael L. Eisenberg and Larry I. LipshultzLarry I. Lipshultz View All Author Informationhttps://doi.org/10.1016/j.juro.2010.11.058AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Estimating the Number of Vasectomies Performed Annually in the United States: Data From the National Survey of Family Growth." The Journal of Urology, 185(4), pp. 1541–1542 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4April 2011Page: 1541-1542 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael L. Eisenberg More articles by this author Larry I. Lipshultz More articles by this author Expand All Advertisement PDF downloadLoading ...

Topic: Male Reproductive Health Studies
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Maritime Transport - Report 1: Review of the Measurement of External Costs of Transportation in Theory and Practice

In the last years public concerns regarding the environmental impacts of maritime transport have been increasing. This is due to the fact that, despite the better environmental performance of this mode of transport with respect to other modes, its overall impacts will be out weighted by the expected increase in the volume of ship movements. In order to define effective measures to internalise the external costs of maritime transport it is necessary to assess these costs and find adequate methodologies to evaluate them. Besides external costs estimation, it is important to understand the degree of internalization of such costs, so as to give some insights on how to apply policy instruments that should be informed by efficiency and equity principles.\n\nThis report summarizes the state of the art in evaluation of transport externalities. Different transport modes have been considered through a comprehensive review of theoretical and empirical studies, by carrying out both EU funded research and national studies. the analytical approach adopted to assess environmental costs (with particular reference to those relating to air emissions) in order to be applicable to maritime transport have to be adjusted to consider the following aspects. 1. The existing literature on climate change external costs focus on shadow price of CO2. However, in maritime transport other GHGs, such as NOx, are relevant. As a consequence, a shadow price for NOx needs to be defined; 2.Health effects of ship emissions depend on exposure to pollutants. Of course this occurs only for activities at ports, whilst health effects of other activities (like cruising) could turn to be negligible to the absence of exposure. Dose response function should consider this aspect.

Topic: Maritime Ports and Logistics
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Effect of Sulfate on Rhenium Partitioning during Melting of Low-Activity Waste Glass Feeds

The volatile loss of technetium-99 (99Tc) is a major concern of the low-activity waste (LAW) vitrification at Hanford. We investigated the incorporation and volatile loss of Re (a nonradioactive surrogate for 99Tc) during batch-to-glass conversion up to 1100°C. The AN-102 feed, which is one of the representative Hanford LAW feeds, containing 0.59 wt% of SO3 (in glass if 100% retained) was used. The modified sulfate-free AN-102_0S feed was also tested to investigate the effect of sulfate on Re partitioning and retention during melting. After heating of the dried melter feed (mixture of LAW simulant and glass forming/modifying additives) to different temperatures, the heat-treated samples were quenched. For each heat-treated sample, the salts (soluble components in room temperature leaching), early glass forming melt (soluble components in 80°C leaching), and insoluble solids were separated by a two-step leaching and the chemical compositions of each phase were quantitatively analyzed. The final retention ratio of AN-102 and AN-102_0S in glass (insoluble solids) are 32% and 63% respectively. The presence of sulfate in the salt phase between 600 and 800°C leads to a significantly higher Re loss via volatilization from the salt layer. At ≥800°C, for both samples, there is no more incorporation of Remore » into the insoluble phase because: for AN-102_0S there is no salt left i.e., the split into the insoluble and gas phases is complete by 800°C and for AN-102 all the Re contained in the remaining salt phase is lost through volatilization. The present results on the effect of sulfate, although not directly applicable to LAW vitrification in the melter, will be used to understand the mechanism of Re incorporation into glass to eventually develop the methods that can increase the 99Tc retention during LAW vitrification at Hanford.« less

Topic: Nuclear materials and radiation effects
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
STRUCTURE FOR THE 2D OVER-COMPLETE

We studied the computational complexity of the over-complete wavelet representation for the commonly used Spline wavelet family with an arbitrary order. By deriving a general expression for the complexity, it is shown that the inverse transform is significantly more costly in computation than the forward transform. In order to reduce the computational complexity, a new spatial implementation is proposed. This new implementation exploits the redundancy between the lowpass and the bandpass outputs that is inherent to the over-complete wavelet scheme. It is shown that the new implementation can greatly simplify the computations, give an efficient inverse structure and allow the use of an arbitrary boundary extension method without affecting the ease of the inverse transform.

Topic: Image and Signal Denoising Methods
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences