jimnoneill/paper-to-field-training huggingface dataset:
The Association Between Hepatitis C Virus Infection and Renal Cell Cancer, Prostate Cancer, and Bladder Cancer: A Systematic Review and Meta-Analysis

<title>Abstract</title> <bold>Background: </bold>To update the current evidence on whether hepatitis C virus (HCV) infection represents a possible risk factor for renal cell cancer (RCC), prostate cancer (PCa) and bladder cancer (BC). <bold>Methods:</bold> We searched literatures on Pubmed, Web of Science and Embases before February 2020. A systematic review and meta-analysis were performed. <bold>Results: </bold>Finally, we extracted 12 studies based on the eligible criteria. Across 11 studies for HCV and RCC, the incorporated RR was 1.28 (95% CI 1.05-1.55), which meant that participants with HCV infection were associated with a higher risk of RCC. The pooled RR in hazard ratio (HR) subgroup (HR 1.59, 95% CI 1.22-2.08), cohort studies (CS) subgroup (RR 1.47, 95% CI 1.18-1.82), and North America subgroup (RR 1.71, 95% CI 1.40-2.09) detected a stronger association between HCV and RCC risk. Although an inverse association was seen for PCa (RR 0.75, 95% CI 0.54-1.03) across 7 studies, it was not statistically significant (P = 0.075). There was no significant association between HCV and BC with an incorporated RR of 0.92 (95% CI, 0.82-1.03) across 5 studies.<bold>Conclusions:</bold> Our study demonstrated that HCV infection was significantly associated with increased RCC risk. There appeared to be an inverse association for HCV in PCa risk but no statistically significant. No significant association was found between HCV and BC risk. Prospective, large-scale and well-designed cohort studies are required to validate the association between HCV and RCC, and to investigate the role of HCV on PCa.

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Estrogen induces cytokeratin aggregation in primary cultures of Armenian hamster hepatocytes

The effect of estrogen administration to cultured Armenian hamster was studied. Isolated Armenian hamster hepatocytes were cultured in RPMI medium supplemented with β-estradiol (E2). β-estradiol treatment for 24–48 hr induced cytoplasmic inclusion bodies which by immunocytochemistry were positive for cytokeratin (CK) 8, CK 18, and ubiquitin but negative for CK 7 and CK 19. These inclusion bodies appeared as filamentous tangles or amorphous aggregates when observed by electron microscopy. F-actin, tubulin, and desmosomes were not influenced by the presence of the inclusion bodies. Addition of ethanol to culture medium increased the incidence of the inclusion formation. In combination with 0.5% ethanol 1 μM of E2 induced five to six times more inclusion bodies, while the number of inclusion bodies decreased when epidermal growth factor (EGF) was added to the medium in combination with E2. This reduction effect was nullified by treatment with anti-EGF receptor antibody. These findings suggest that E2 treatment to Armenian hamster hepatocytes in vitro induces Mallory body-like inclusions whose incidence can be influenced by addition of ethanol or EGF to the culture medium. Cell Motil. Cytoskeleton 43:35–42, 1999. © 1999 Wiley-Liss, Inc.

Topic: Liver physiology and pathology
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
MSJ918978_supplemental_material – Supplemental material for Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study

Supplemental material, MSJ918978_supplemental_material for Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study by Svenja Kiljan, Paolo Preziosa, Laura E Jonkman, Wilma DJ van de Berg, Jos Twisk, Petra JW Pouwels, Geert J Schenk, Maria A Rocca, Massimo Filippi, Jeroen JG Geurts and Martijn D Steenwijk in Multiple Sclerosis Journal

Topic: Multiple Sclerosis Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Brief Introduction to Internal Auditing in Geological Prospecting Units

Internal auditing means an independent,objective supervision and evaluation activities in the inner of an organization,which aims at reaching the object via examination and evaluation of business activities and plus the adaptability,legal nature,and availability of internal control.The current internal auditing has developed very slowly.On this account,the paper offers some suggestions for improving this situation,these include: making the functions of internal auditing clear,establishing and perfecting the organization,disposing personnel scientifically and rationally,standardizing the contents and range and perfecting internal control system.

Topic: Reservoir Engineering and Simulation Methods
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
A Study on Transparent Electrode Properties of Indium Tin Oxide Thin Films Deposited From Recycled Target

In this study, we investigated the transparent electrode and mechanical properties of indium tin oxide (ITO) thin films deposited from recycled targets of In 2 O 3 (90 wt %) and SnO 3 (10 wt %). We also evaluated the effect of their heat treatment at different temperatures. The ITO thin film deposited on the glass substrate at ambient temperature exhibited microcrystallization characteristics in which the amorphous state was incorporated. When the annealing temperature was over 200 °C, the ITO thin film showed stable transparent electrode characteristics with a sheet resistance value of 7.2 Ω/sq and high transmittance of more than 85% in the visible light region through recovery and recrystallization. Under compressive stress, the ITO thin film exhibited stable elastic modulus and hardness values of more than 110 GPa and 6.0 GPa, respectively. It is anticipated that these outcomes will meet the electrical, optical, and mechanical property requirements for commercial ITO transparent electrodes.

Topic: ZnO doping and properties
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Correction: DNA barcodes corroborating identification of mosquito species and multiplex real-time PCR differentiating Culex pipiens complex and Culex torrentium in Iran

[This corrects the article DOI: 10.1371/journal.pone.0207308.].

Topic: Mosquito-borne diseases and control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Basics and guidelines of complementary filters for small UAS navigation

Orientation estimation is very important for development of unmanned aerial systems (UAS). Kalman filters are widely used; however they assume linearity and Gaussian statistics. While these assumptions work well for high-quality, high-cost sensors, they do not work as well for low-cost, low-quality sensors. In these cases, complementary filters are used since no assumptions are made with regards to linearity and statistics. This paper gives a review of the different types of complementary filters being developed. Basic examples are shown with details about how they are derived and simulations that show how they work. Guidelines are then given about when complementary filters are best used for UAS navigation.

Topic: Target Tracking and Data Fusion in Sensor Networks
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Development of Land Markets in Selected EU-Countries and Land Ownership Strategies on the Farm Level

The development of the land markets for selected European Countries (B, DK, D-W, F, NL) and the effects of agricultural policy reforms on land prices are analysed in "Part I - Land Markets at the Country Level" of this article. The variables describing the agricultural land markets are land prices, prices for rental land and the share of rented land. Over a longer period of about two decades, the prices for agricultural land have been decreasing in real terms in general (exception NL) while rental prices have been more stable. A regression analysis shows increasing price effects on prices for agricultural land and on rental prices due to the ha-premiums, which were introduced by the Common Agricultural Policy(CAP)-Reforms in 1992. In "Part II - Farm Level Strategies for Land Purchase" the economic effects of changing land ownership are analysed using the data base of Part I. Recommendations for farmers are to find out if long term rental contracts are available to avoid tying up capital. If land market prices are lower than a certain threshold, land can be bought considering the financial liquidity of the enterprise. Selling land could be appropriate to avoid financial liquidity stress, but this should be only temporary and restricted to a marginal amount of land stocks. If profitability of crop production is relatively low or land prices are relative high and rental contracts terminated, an entrepreneur should seek to rent new land, if possible, or find alternative investments which yield higher profits than crop production.

Topic: Agricultural Economics and Policy
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Acetaldehyde-induced impairment of protein glycosylation in liver Golgi apparatus.

The effects of acute ethanol intoxication on the glycoprotein metabolism of rat liver Golgi apparatus have been investigated. A marked reduction of the galactosyltransferase and sialyltransferase activities was observed in Golgi membranes 6 h after ethanol administration (6g/Kg body wt) together with the retention of glycoproteins in the hepatocyte. Methylpyrazole, an inhibitor of alcohol dehydrogenase, administrated "in vivo" (10 mg/Kg body wt) prevented the ethanol-induced inhibition of both the transferase activities. Acetaldehyde formed "in vitro" unstable and stable adducts with Golgi membrane proteins and with purified galactosyltransferase. These results suggest that the impairment of glycoprotein metabolism at the level of liver Golgi apparatus may be mediated, at least in part, through the acetaldehyde formation during ethanol oxidation.

Topic: Alcohol Consumption and Health Effects
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Communication Theory Of Identity: Artists Becoming Politicians (Case Study Nafa Urbach): Systematic Literature Review

This systematic literature review explores the identity transformation of artists transitioning into politics, using Nafa Urbach's journey as a case study and applying the Communication Theory of Identity (CTI) by Michael Hecht. The study aims to identify key factors influencing this transition, including communication strategies, media portrayals, and public perceptions. Through a comprehensive analysis of scholarly literature, this review examines how artists negotiate their identities across personal, relational, communal, and material frames to gain political legitimacy. The findings indicate that artists must strategically communicate their political agenda and reshape their public image to establish credibility and overcome initial skepticism from both the public and media. Media portrayals significantly influence audience perception, underscoring the need for effective media engagement strategies. The study also highlights the broader implications of identity transformations on political communication dynamics. As artists navigate dual expectations from their entertainment fanbase and politically engaged audiences, maintaining a coherent and relatable identity becomes crucial for political success. The research contributes to a deeper understanding of how communication strategies shape identity negotiation and political acceptance for celebrity politicians. This review offers practical insights for political campaign strategists and media professionals while laying a foundation for future studies on identity formation in political contexts.

Topic: Jewish and Middle Eastern Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Can neighborhoods protect residents from mental distress during the COVID-19 pandemic? Evidence from Wuhan

Neighborhoods have begun to play an increasingly prominent role in shaping mental health during the coronavirus disease 2019 (COVID-19) pandemic because residents are spending more time at home and in their immediate neighborhoods. Using data collected from 3,031 urban residents during the COVID-19 lockdown of Wuhan, China’s earliest epicenter, this study investigates the relationship between neighborhoods’ social infrastructure and residents’ mental distress. Results of structural equation modeling estimation reveal that services provided by urban residents’ committees (cheng shi ju wei hui) and volunteer groups significantly decrease the adverse impact of the COVID-19 outbreak on residents’ mental health in a Chinese context, and social cohesion is one of the mechanisms underpinning this influence. Residents’ committees and volunteer groups are found to increase their support when neighborhoods are facing an escalated level of COVID-19 risk. The residents who receive more support from their neighborhood organizations perceive a higher level of social cohesion and experience less mental distress. The findings suggest that mobilizing neighborhoods’ organizational resources and fostering social cohesion are crucial strategies to minimizing residents’ mental distress during COVID-19 pandemic. © 2020 Taylor &amp; Francis Group, LLC.

Topic: Health disparities and outcomes
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
HF-UHF pulse shaping for testing high-speed circuits

The paper discloses a method of construction and the results of examining of the ultra wideband pulse signals shaping device designed for testing integrated circuits. The paper analyses the devices with linear and nonlinear transformations of the amplitude and phase signal spectrum. Phase method for defining the parameters of the pulse signal is proposed. A shaper on a powerful GaAs current switch is experimentally tested over the front duration and maximum frequency, limits of regulation and the error of assignment of pulse levels.

Topic: Advanced Research in Systems and Signal Processing
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Complex Software Systems in Legacy and Modern Environments: A Case Study of the PicklingTools Library

Most complex software systems are written in many languages and utilize multiple frameworks. The PicklingTools is an open-source collection of libraries (see the website at http://www.picklingtools.com) allowing multiple systems (both modern and legacy) to communicate. The original purpose of the PicklingTools was to allow users to communicate with a legacy product (written with a monolithic legacy framework called Midas 2k) without needing the legacy framework. Since then, the toolset has evolved to become a standalone framework for building applications in the C++ and Python programming languages. This case-study explores how the PicklingTools has been used to evolve existing legacy applications, exploit existing legacy installations, and author new modern applications.

Topic: Scientific Computing and Data Management
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Protective Effects of Active Compounds from Salviae miltiorrhizae Radix against Glutamate-Induced HT-22 Hippocampal Neuronal Cell Death

Oxidative stress is considered one of the factors that cause dysfunction and damage of neurons, causing diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and Parkinson’s disease (PD).Recently, natural antioxidant sources have emerged as one of the main research areas for the discovery of potential neuroprotectants that can be used to treat neurological diseases. In this research, we assessed the neuroprotective effect of a 70% ethanol Salvia miltiorrhiza Radix (SMR) extract and five of its constituent compounds (tanshinone IIA, caffeic acid, salvianolic acid B, rosmarinic acid, and salvianic acid A) in HT-22 hippocampal cells. The experimental data showed that most samples were effective in attenuating the cytotoxicity caused by glutamate in HT-22 cells, except for rosmarinic acid and salvianolic acid B. Of the compounds tested, tanshinone IIA (TS-IIA) exerted the strongest effect in protecting HT-22 cells against glutamate neurotoxin. Treatment with 400 nM TS-IIA restored HT-22 cell viability almost completely. TS-IIA prevented glutamate-induced oxytosis by abating the accumulation of calcium influx, reactive oxygen species, and phosphorylation of mitogen-activated protein kinases. Moreover, TS-IIA inhibited glutamate-induced cytotoxicity by reducing the activation and phosphorylation of p53, as well as by stimulating Akt expression. This research suggested that TS-IIA is a potential neuroprotective component of SMR, with the ability to protect against neuronal cell death induced by excessive amounts of glutamate.

Topic: Traditional Chinese Medicine Analysis
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Micro-/Nano-Texturing of Aluminum by Precise Coining for Functional Surface Decoration

The AISI316 austenitic stainless steel die was prepared and nitrided at 673 K for 14.4 ks. Through this low temperature plasma nitriding, the AISI316 die was homogeneously hardened up to 1400 HV within its surface layer of 50 μm. This nitrided AISI316 die was utilized to print the tailored micropattern with nanotextures onto its surface by the femtosecond laser processing. Each micropattern consisted of the tailored segments to have unidirectional nanotextures with different orientations. Each segment was recognized by its intrinsic surface plasmonic brilliance to tailored nanotextures. The CNC (Computer Numerical Control) stamping system was used to coin these micropatterns with nanotextures onto the AA1060 aluminum plates with the thickness of 1 mm. SEM (Scanning Electron Microscopy) and optical microscopy were employed to characterize the original micro-/nano-textures on the AISI316 die as well as the coined nanotextured patterns on the AA1060 plate surfaces.

Topic: Metal and Thin Film Mechanics
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Development and Validation of a Rapid HPLC Method for the Direct Determination of Colchicine in Pharmaceuticals and Biological Fluids

Abstract A reversed‐phase high performance liquid chromatographic (RP‐HPLC) method is developed and validated for the determination of the colchicine, an anti‐gout alkaloid. The analytical column, an Inertsil ODS‐2, 5 µm, 250×4 mm, was operated at ambient temperature. Isocratic elution with A: 48% CH3COONH4 0.05 M and B: 52% CH3OH, was used at a flow rate of 1.0 mL/min. Inlet pressure was 270 kg/cm2. UV detection was performed at 245 nm. The Limit of Detection was 0.5 ng, per 20 µL injection volume, while linearity held up to 2.5 ng/µL. Codeine was used as Internal Standard at a concentration level of 10 ng/µL. The statistical evaluation of the method was performed in terms of intra‐day (n=8) and inter‐day calibration (n=8) and was found to be satisfactory, with high accuracy and precision results. The method was successfully applied to commercial pharmaceuticals and biological fluids. Blood serum samples, after deproteinization with acetonitrile, yielded high recovery rates from 97.2 to 104.6%, while direct analysis of urine after a 10‐fold dilution provided recovery rates ranging from 89.5 to 104.0%. Keywords: ColchicinePharmaceuticalsBiological fluidsSerumUrineHPLC Acknowledgments The authors would like to thank Professor P. Nikitas (Laboratory of Physical Chemistry, Chemistry Department of University of Thessaloniki) for kindly providing the chromatographic software for data acquisition.

Topic: Drug-Induced Hepatotoxicity and Protection
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Factors Associated With Acceptance of Telehealth-Based Antimicrobial Stewardship Program Recommendations in a Community Hospital Health System

Abstract Background Telehealth-based antimicrobial stewardship programs (TeleASPs) have led to reduced broad-spectrum antimicrobial utilization. Data on factors associated with acceptance of stewardship recommendations are limited. Methods A TeleASP, facilitated by remote infectious disease physicians and local pharmacists, was implemented in 2 community hospitals from February 2018 through July 2020. Variables potentially affecting acceptance of TeleASP recommendations were tracked. Odds ratios of acceptance were determined utilizing multiple logistic regression. Results During the 30-month period, 4863 (91.2%) of the total 5333 recommendations were accepted. Factors associated with a higher odds of acceptance in multivariable analysis were recommendations for antimicrobial dose/frequency adjustment (odds ratio [OR], 2.63; 95% CI, 1.6–4.3) and order for labs/tests (OR, 3.30; 95% CI, 2.1–5.2), while recommendations for antimicrobial de-escalation (OR, 0.75; 95% CI, 0.60–0.95) and antimicrobial discontinuation (OR, 0.57; 95% CI, 0.42–0.76) were associated with lower odds of acceptance. Female physicians were more likely to accept recommendations compared with males (93.1% vs 90.3% acceptance; OR, 1.65; 95% CI, 1.3–2.2). Compared with physicians with &amp;lt;3 years of experience, who had the highest acceptance rate (96.3%), physicians with ≥21 years of experience had the lowest (87.1%; OR, 0.26; 95% CI, 0.15–0.45). Conclusions TeleASP recommendations were accepted at a high rate. Acceptance rates were higher among female physicians, and recommendations to stop or de-escalate antimicrobials led to lower acceptance. Recommendations made to the most experienced physicians were the least accepted, which may be an important factor for stewardship programs to consider in education and intervention efforts.

Topic: Antibiotic Use and Resistance
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Challenges of Commutation -- An Advertisement

We consider a few problems connected to the commutation of languages, in particular finite ones. The goal is to emphasize the challenging nature of such simply formulated problems. In doing so we give a survey of results achieved during the last few years, restate several open problems and illustrate some approaches to attack such problems by two simple constructions.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences