jimnoneill/paper-to-field-training huggingface dataset:
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL) patients and compared it to non-high-risk APL cases. Despite the lack of common genetic signatures, we found that human hrAPL blasts from patients with extremely poor prognosis display specific patterns of histone H3 acetylation, specifically hyperacetylation at a common set of enhancer regions. In addition, unique profiles of the repressive marks H3K27me3 and DNA methylation were exposed in high-risk APLs. Epigenetic comparison with low/intermediate-risk APLs and AMLs revealed hrAPL-specific patterns of histone acetylation and DNA methylation, suggesting these could be further developed into markers for clinical identification. The epigenetic drug MC2884, a newly generated general HAT/EZH2 inhibitor, induces apoptosis of high-risk APL blasts and reshapes their epigenomes by targeting both active and repressive marks. Together, our analysis uncovers distinctive epigenome signatures of hrAPL patients, and provides proof of concept for use of epigenome profiling coupled to epigenetic drugs to 'personalize' precision medicine.

Topic: Retinoids in leukemia and cellular processes
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Cytochrome <scp>P450 2J2</scp> is required for the natural compound austocystin D to elicit cancer cell toxicity

Abstract Austocystin D is a natural compound that induces cytochrome P450 (CYP) monooxygenase‐dependent DNA damage and growth inhibition in certain cancer cell lines. Cancer cells exhibiting higher sensitivity to austocystin D often display elevated CYP2J2 expression. However, the essentiality and the role of CYP2J2 for the cytotoxicity of this compound remain unclear. In this study, we demonstrate that CYP2J2 depletion alleviates austocystin D sensitivity and DNA damage induction, while CYP2J2 overexpression enhances them. Moreover, the investigation into genes involved in austocystin D cytotoxicity identified POR and PGRMC1 , positive regulators for CYP activity, and KAT7 , a histone acetyltransferase. Through genetic manipulation and analysis of multiomics data, we elucidated a role for KAT7 in CYP2J2 transcriptional regulation. These findings strongly suggest that CYP2J2 is crucial for austocystin D metabolism and its subsequent cytotoxic effects. The potential use of austocystin D as a therapeutic prodrug is underscored, particularly in cancers where elevated CYP2J2 expression serves as a biomarker.

Topic: Pharmacogenetics and Drug Metabolism
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
A numerical insight into stress mode shapes of rectangular thin-plate structures

Thin-plate structures are widely exploited in many areas due to their excellent structural properties. This study numerically investigates the mechanics characteristics of the stress mode shapes (SMSs) in thin plates. First, theoretical basis of the SMSs is concisely illustrated for thin-plate structures. Then, finite element models are constructed in numerical simulations. The SMSs of the flat plate are compared with the conventional displacement mode shapes (DMSs). The modal participation factors (MPFs) are used to extract the predominant SMSs. The SMSs in x-, y-, xy- directions and von Mises stress are evaluated in detail. Based on results of the flat plate, local thickness and elastic modulus modifications are performed to examine the changes in SMSs. Modal assurance criterion (MAC) is utilized to evaluate the modal data. The information of SMSs from the modified plates indicates the powerful capability for detecting the local variations of structural properties. Lastly, modal order determination via modal effective mass is numerically verified for accurate dynamic stress calculation.

Topic: Structural Health Monitoring Techniques
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
Productive Inconvenience: Facilitating Posture Variability by Stimulating Robot-to-Human Handovers

Collaborative robots that physically interact with humans in an ergonomic and safe manner are essential to the future of industry. A common task across many industrial applications is robot-to-human handover, in which the location of object exchange is vital in cultivating a seamless interaction. Most prior work on computing these exchange locations aims to adjust human posture towards a better ergonomic state during a single handover. This procedure typically involves the robot estimating the human's biomechanical properties, e.g. center of mass and base of support, before determining an optimal handover location according to some ergonomics assessment scale. In a similar vein, we compare two methodologies for object handover, whereby the handover location is computed to either "assist" or "stimulate" the human receiver. Unlike existing approaches, we posit that improvements in human posture can be derived by stimulating the receiver's movement dynamics to facilitate posture variability, rather than constrain or stabilize it. To compare methodologies, we conduct a within-subjects study where participants perform 78 object handovers with a collaborative robot architecture. Our ndings indicate an improvement in ergonomics scores for the "stimulating" approach, hinting at the importance of productive inconvenience in long-term robot-to-human handover.

Topic: Robot Manipulation and Learning
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone

We report a case of diffuse large B-cell lymphoma (DLBCL) treated successfully with clarithromycin (CAM) and prednisolone (PSL). A 71-year-old woman presented with fever and cervical pain. DLBCL was diagnosed based on histological results from lymph node biopsy. Cervical pain was thought to be caused by the invasion of lymphoma cells into the cervical vertebrae. She initially received radiotherapy for the cervical lesion. She did not receive conventional chemotherapy because of the risk of recurrent non-tuberculous mycobacteria infection; therefore, she was treated with 20 mg/day PSL and 800 mg/day CAM to induce apoptosis in lymphoma cells. Complete remission was achieved after 6 months. The present findings suggest that CAM and PSL may be effective in some cases of DLBCL.

Topic: Lymphoma Diagnosis and Treatment
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
THE INFLUENCE OF THE COMMEDIA DELL'ARTE ON THE FRENCH THEATRE BEFORE 1640

Journal Article THE INFLUENCE OF THE COMMEDIA DELL'ARTE ON THE FRENCH THEATRE BEFORE 1640 Get access R. C. D. PERMAN R. C. D. PERMAN OXFORD Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume IX, Issue 4, October 1955, Pages 293–303, https://doi.org/10.1093/fs/IX.4.293 Published: 01 October 1955

Topic: Renaissance Literature and Culture
Subfield: Classics
Field: Arts and Humanities
Domain: Social Sciences
Strategies and Challenges of Timestamp Tampering for Improved Digital Forensic Event Reconstruction (extended version)

Timestamps play a pivotal role in digital forensic event reconstruction, but due to their non-essential nature, tampering or manipulation of timestamps is possible by users in multiple ways, even on running systems. This has a significant effect on the reliability of the results from applying a timeline analysis as part of an investigation. In this paper, we investigate the problem of users tampering with timestamps on a running (``live'') system. While prior work has shown that digital evidence tampering is hard, we focus on the question of \emph{why} this is so. By performing a qualitative user study with advanced university students, we observe, for example, a commonly applied multi-step approach in order to deal with second-order traces (traces of traces). We also derive factors that influence the reliability of successful tampering, such as the individual knowledge about temporal traces, and technical restrictions to change them. These insights help to assess the reliability of timestamps from individual artifacts that are relied on for event reconstruction and subsequently reduce the risk of incorrect event reconstruction during investigations.

Topic: Digital and Cyber Forensics
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Nuclear Risk and Rationality: Reevaluating Rational Decision Making through the Lens of Tohoku’s Nuclear Evacuees

The purpose of this paper is the examination of previous STS-based frameworks for rational risk evaluation and the role of Fukushima residents as co-creators of new technical codes in safety and risk. To accomplish this task, the causes of nuclear refugees’ uncertainty and distrust towards the industry and the applicability of frameworks for scientific proceduralism and democratic rationalization by Kristin Shrader-Frechette and Andrew Feenberg to this issue will be discussed.

Topic: Nuclear and radioactivity studies
Subfield: Safety, Risk, Reliability and Quality
Field: Engineering
Domain: Physical Sciences
Electro Steam Thermal Complex Powered by Wind-Driven Generator for the Treatment of the Oil Formation’s Bottomhole Area

Abstract In this article authors propose application of the wind-driven power units as power source of bottomhole electric steam generator for the thermal high-viscosity oil reservoir stimulation. The structure of the electro steam thermal complex is proposed. An analysis of the wind energy potential in the areas where the largest high-viscosity oil deposits in Russia are located is carried out. As part of the complex under consideration, the type of the dependence of the bottomhole electric steam generator’s power on the formation depth has been established. The calculation of the required installed capacity of wind power plants for placement as part of the electro steam thermal complex at the largest high-viscosity oil deposits in Russia has been performed.

Topic: Enhanced Oil Recovery Techniques
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Nonstationary Optimal Control of Dual-Stage Actuator System Including Spring and Damping Elements.

Nonstationary optimal regulator (NOR) is one of the effective methods for positioning control of vibration systems. NOR corresponds to an LQ regulator utilizing time-varying weighting functions and produces positioning trajectories taking the vibration characteristic of a controlled object into account. Generally, many positioning or tracking mechanisms such as information equipments, machine tools and robots adopt dual-stage actuator systems (DSASs). DSASs consist of coarse and fine actuators and realize efficient and high performance responses. However, the control method for DSASs with mechanical flexibility has not been fully addressed. This study utilizes the NOR technique for positioning control of DSASs taking spring and damping elements of controlled objects into account. We use a proper combination of time-varying weights for this problem. The effectiveness of this method is verified by numerical calculations and experiments.

Topic: Dynamics and Control of Mechanical Systems
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
VALUATIVE DOMAINS

A (commutative integral) domain R is said to be valuative if, for each nonzero element u in the quotient field of R, at least one of R ⊆ R[u] and R ⊆ R[u -1 ] has no proper intermediate rings. Such domains are closely related to valuation domains. If R is a valuative domain, then R has at most three maximal ideals, and at most two if R is not integrally closed. Also, if R is valuative, the set of nonmaximal prime ideals of R is linearly ordered, at most one maximal ideal of R does not contain each nonmaximal prime of R, and R P is a valuation domain for each prime P except for at most one maximal ideal. Any integrally closed valuative domain is a Bézout domain. Valuation domains are characterized as the quasilocal integrally closed valuative domains. Each one-dimensional Prüfer domain with at most three maximal ideals is valuative.

Topic: Rings, Modules, and Algebras
Subfield: Algebra and Number Theory
Field: Mathematics
Domain: Physical Sciences
Use of the oyster Crassostrea gigas embryo bio-assay on water and sediment elutriate samples from the German Bight

Oyster embryo bioassays were carried out on samples of sub-surface water, surface microlayer and sediment elutriates collected during the Bremerhaven Workshop from 9 stations along a transect from the inner German Blght to the Dogger Bank.The results gave no indication of poor water quality in the surface waters.Oyster embryo development was impaired in 2 of the 4 surface microlayer samples and in the sediment elutriate samples from the 3 inner stations.

Topic: Marine Bivalve and Aquaculture Studies
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
Religion and the State in Singapore

Journal Article Religion and the State in Singapore Get access Joseph B. Tamney Joseph B. Tamney Professor of Sociology Ball State University in Muncie, Indiana Search for other works by this author on: Oxford Academic Google Scholar Journal of Church and State, Volume 30, Issue 1, Winter 1988, Pages 109–128, https://doi.org/10.1093/jcs/30.1.109 Published: 01 January 1988

Topic: Socioeconomic Development in Asia
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Highly Reversible Ambipolar Photocurrents by Modulating Ta in Ba<sub>2</sub>Bi<sub>2–<i>x</i></sub>Ta<i><sub>x</sub></i>O<sub>6</sub> Double Perovskites

Ta5+-doped Ba2Bi2–xTaxO6 (0.2 ≤ x ≤ 0.8) double perovskites are synthesized by a soft chemical sol–gel method. X-ray diffraction (XRD) results show the formation of a double perovskite structure. Systematic shifts of Bragg diffraction peaks to larger angles confirm the incorporation of increasing amounts of Ta5+ dopant ions in the Ba2Bi2O6 (BBO) crystal lattice. The optical absorption spectra and Tauc plots reveal a monotonic increase of the optical band gaps for Ba2Bi2–xTaxO6 (0.2 ≤ x ≤ 0.8) from 1.5 to 2.3 eV. Photoelectrochemical (PEC) and electrochemical tests signify the advantages of doping Ta5+ in improving the photoelectrode resistance to electrochemical corrosion. Highly reversible ambipolar photocurrents are observed for photoelectrodes with x ≥ 0.4 that can be further enhanced by anodic or cathodic poling treatment for facilitated interface photocharge injection. Ba2Bi1.6Ta0.4O6 photoelectrodes exhibit both the highest cathodic photocurrent of 65.5 μA cm–2 at 0 VRHE with an onset potential of 1.43 VRHE, and the highest anodic photocurrent of 37 μA cm–2 at 2 VRHE with an onset potential of 1.03 VRHE among other Ta5+ containing counterpart samples. The deteriorating PEC photocurrents of photoelectrodes with x ≥ 0.5 are the result of both inferior light absorption ability due to large band gaps and lower charge carrier concentrations due to defect compensation. The understanding and control of this switchable-photocurrent phenomenon by doping strategies are significant to further tailor the electronic band structure for compatible homojunctions of BBO-based double perovskites.

Topic: Perovskite Materials and Applications
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Measuring the Impact of Electronic Publishing on Citation Indicators of Education Journals

With the growth in electronic availability and distribution of scholarly journals, citation indicators of these journals may be expected to change. This study estimated how electronic publishing affects citation indicators, Impact Factors and Immediacy Indexes, from 1995 to 2003. Two citation indicators of 70 journals in education, educational research, and special education in Journal Citations Reports were analysed in this study. The result shows that Impact Factors remain essentially unchanged while Immediacy Indexes increased significantly. For all journals, 75% had their Immediacy Indexes increase drastically recently and had higher Impact Factors than average. Because more journal articles are available in electronic form, both as part of complete electronic journals and within databases of separate articles, many more scientists access and use new articles without delay than in the past. Electronic publishing can be regarded as one of the factors affecting not only citation frequencies but also citation indicators. Digital access to scholarly journals promises to bring changes in citation indicators, especially Immediacy Indexes of well-established journals in education.

Topic: scientometrics and bibliometrics research
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Using Dynamic Semantic Network to Construct Knowledge Base

Knowledge base building is a key branch of modern artificial intelligence research. Current methods in this field mainly focus on computational efficiency, decidability, data exchange, and machine readability. In this paper, a novel human like knowledge representation method called dynamic semantic network (DSN) is proposed. With the inspiration of high level human brain cognitive models, DSN aims at building more practical and abundant knowledge base. The inference and learning mechanism on DSN are latterly studied. And the construction issues are also discussed.

Topic: Cognitive Computing and Networks
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Agents that enhance or reduce movement of mobile genetic elements: Detection in microbial assays and implications for toxicological assessment

Abstract A comprehensive assessment of the potential toxicological effects of an environmental chemical or mixture of chemicals must take into account the possibility of genetic damage to cellular organisms. In conventional assays (e.g., the Ames test), point mutations (both base‐pair substitutions and frameshifts) have come into widespread use as indicators of genetic damage, but it is important that such end points be supplemented by indicators of more extensive genetic damage such as deletions or other large scale rearrangements of sections of genetic material. In the present paper, the ability of certain chemicals to cause gross changes to DNA sequences will be reviewed. The changes to be considered are primarily those that result from movements of mobile genetic elements, and focus especially on description and discussion of factors that enhance or inhibit the movement of transposons such as Tn 10 . © 1993 John Wiley &amp; Sons, Inc.

Topic: Genetically Modified Organisms Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Mean-field games with logistic population dynamics

In its standard form, a mean-field game can be defined by coupled system of equations, a Hamilton-Jacobi equation for the value function of agents and a Fokker-Planck equation for the density of agents. Traditionally, the latter equation is adjoint to the linearization of the former. Since the Fokker-Planck equation models a population dynamic, we introduce natural features such as seeding and birth, and nonlinear death rates. In this paper we analyze a stationary meanfield game in one dimension, illustrating various techniques to obtain regularity of solutions in this class of systems. In particular we consider a logistic-type model for birth and death of the agents which is natural in problems where crowding affects the death rate of the agents. The introduction of these new terms requires a number of new ideas to obtain wellposedness. In a forthcoming publication we will address higher dimensional models. ©2013 IEEE.

Topic: Stochastic processes and financial applications
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
TASEP with Discontinuous Jump Rates

We prove a hydrodynamic limit for the totally asymmetric simple exclusion process with spatially inhomogeneous jump rates given by a speed function that may admit discontinuities. The limiting density profiles are described with a variational formula. This formula enables us to compute explicit density profiles even though we have no information about the invariant distributions of the process. In the case of a two-phase flow for which a suitable p.d.e. theory has been developed we also observe that the limit profiles are entropy solutions of the corresponding scalar conservation law with a discontinuous speed function.

Topic: Stochastic processes and statistical mechanics
Subfield: Mathematical Physics
Field: Mathematics
Domain: Physical Sciences
Effect of Modification Manner on the Photodynamic Antitumor Activity of C60 Modified with Pullulan

To design a novel cytospecific photosensitizer for photodynamic antitumor therapy, a fullerene (C(60)) was chemically modified with pullulan, a water-soluble polysaccharide with a high affinity for asialoglycoprotein receptors (ASGPRs). The effect of the molecular weight of pullulan and the modification manner to C(60) on the photodynamic antitumor activity of C(60) modified with pullulan was evaluated. In this study, two modification manners were selected. First, ethylene diamine was chemically introduced to the hydroxyl groups of pullulan with different molecular weights. Then, C(60) was coupled to pullulan through the amino groups introduced (pendant type). Second, ethylene diamine was introduced to the terminal aldehyde groups of pullulan by a reductive amination reaction, and then the pullulan with the terminal amino groups was coupled to C(60) (terminal type). Irrespective of the pullulan molecular and the modification manner, the C(60)-pullulan conjugates exhibited a similar ability to generate superoxide anions upon light irradiation. Comparing the C(60)-pullulan conjugates of pendant and terminal types, a high lectin affinity was observed for the latter conjugates. The conjugates showed a high affinity for HepG2 cells with ASGPRs and, consequently, a strong in vitro antitumor activity on the cells. It is concluded that the manner of pullulan modification is a key factor contributing to the photodynamic antitumor activity of modified C(60).

Topic: Fullerene Chemistry and Applications
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Facilitation of diphosphate group elimination from geranyl diphosphate by magnesium ion chelation in cyclic monoterpenoid biosynthesis

The role of divalent metal ions in the biosynthesis of cyclic monoterpenoids has been investigated by an analysis of the 31P and 13C NMR spectra of geranyl diphosphate (GPP) in the presence and in the absence of Mg2+. This study revealed that Mg2+ binds to the diphosphate moiety of GPP in the ratio of 1 : 1, equidistantly from both phosphorus atoms, and that Mg2+ chelation weakens the C(1 )–O(5) bond of GPP, facilitating elimination of the diphosphate group.

Topic: Plant biochemistry and biosynthesis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences