jimnoneill/paper-to-field-training huggingface dataset:
Development of a facial biocosmetic containing levan, almond and cinnamon oils with antioxidant and moisturizing properties

The addition of natural molecules such as microbial exopolysaccharides in cosmetics is a trend in the current market, adding properties and improving the product quality. Therefore, the aim of this study was to develop a facial biocosmetic formulation containing microbial levan, almond and cinnamon oils. The centroid-simplex design was used to evaluate the spreadability, antioxidant activity, moisture retention capacity and viscosity of formulations. Since it is a facial cosmetic, the formulation was optimized using the intermediate viscosity. The optimized formulation with intermediate viscosity was 75% (0.75 g) levan and 25% (2 mL) almond oil, without the addition of cinnamon oil. This formulation was submitted to 90 days under different exposure conditions, and the results showed a spreadability of 805 mm2, pH and density ideal for the facial area, with an antioxidant activity of 72%, hydration capacity of 100.3%, viscosity with no-Newtonian behavior, and normal organoleptic properties when stored at room and low temperature. The formulation with levan associated with almond oil showed potential for application in the facial area, with high antioxidant properties, moisturizing intermediate viscosity and stability for 90 days. The utilization of centroid-simplex design allowed the development of a biocosmetic with desired characteristics just by adjusting the concentrations of the bioactive.

Topic: Microbial Metabolites in Food Biotechnology
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
IL-17A Contributes to the Angiotensin II-induced Neurovascular Coupling impairment through Oxidative Stress

Abstract Hypertension, a multifactorial chronic inflammatory condition, is a risk factor for neurodegenerative diseases including stroke and Alzheimer’s disease. These diseases have been associated with higher concentration of blood interleukin (IL)-17A. However, the role that IL-17A plays in the relationship between hypertension and brain remains misunderstood. Cerebral blood flow regulation may be the crossroads of these conditions. Hypertension alters cerebral blood flow regulation including neurovascular coupling (NVC). In the present study, the effects of IL-17A on NVC in the context of hypertension induced by angiotensin (Ang) II will be examined. Our results show that the neutralization of IL-17A or the specific inhibition of its receptor prevent the Ang II- induced NVC impairment. These treatments reduce the Ang II-induced cerebral oxidative stress. Tempol and NOX-2 depletion prevent NVC impairment induced by IL-17A. These findings suggest that IL-17A, through superoxide anion production, is an important mediator of cerebrovascular dysregulation induced by Ang II.

Topic: Neuroinflammation and Neurodegeneration Mechanisms
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
The Effectiveness of Hybrid and Pure Problem-Based Learning in the Productive Skills and Critical Thinking of Iranian Undergraduate Students through MALL Application

Hybrid problem-based learning (HPBL) as a learner-oriented method involves learning through collaboration while finding solutions to real-world problems. It has been employed in the education of English as a foreign language (EFL) students recently. Implementation of it in an EFL classroom, though might be a challenging task, has been approved a useful method for improving learning of the students. The current study, using a quasi-experimental design, IELTS pretests-posttests, and Honey’s critical thinking questionnaire, attempted to find out the effectiveness of HPBL method in the productive skills and critical thinking of the students by implementing it in an EFL classroom using eight teacher’s made problems through Mobile Assisted Language Learn (MALL) application. The subjects were 60 Iranian undergraduates grouped as one control group (CG) being instructed based on the traditional lecture-based method and two experimental groups being instructed based on HPBL and Pure Problem-Based Learning (PPBL) methods conveniently. Findings of one-way MANOVA, one-sample, and paired-samples t-test revealed that HPBL students had significantly higher mean scores than the PPBL students who were in turn superior to their CG counterparts in terms of productive skills and critical thinking. This study has the potential to advance new ideas and perceptions which can be implemented by EFL learners in improving the productive skills and critical thinking of the learners. Therefore, the findings might bear implications for students, teachers, university curriculum designers, and decision-makers to design more effective curriculums for the teaching of productive skills to the students.

Topic: Problem and Project Based Learning
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
‘Uphill’ permeation of carbon dioxide across a composite molten salt-ceramic membrane

Here, we show how a membrane can be designed and operated to achieve 'uphill' permeation of carbon dioxide against its own chemical potential difference by employing the transport of carbonate ions with coupled 'downhill' permeation of oxygen. Absolute values of the carbon dioxide permeability of the order of 106 Barrers are achieved experimentally over more than 200 h of operation. These permeabilities are some four orders of magnitude greater than polymeric gas separation membranes. We believe that these high permeabilities are due to the effective use of the oxygen chemical potential difference across the membrane as a driving force for carbonate transport.

Topic: Membrane Separation and Gas Transport
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
An Analysis Of Illocutionary Act In The Fault In Our Stars' Film Directed By Josh Boone

This study aims at describing the use of Illocutionary Act in “The Fault in Our Stars” film’ script directed by Josh Boone. The writer used qualitative method that focused on the analysis of utterances, types and functions. A theory from Searle (1979) was chosen to analyze the types of illocutionary act. While a theory from Leech (1983) was chosen to support the analysis of types of illocutionary act based on context. Based on the result of the study, it was found 30 data of illocutionary act from “The Fault in Our Stars” film. The data were classified based on their types, functions and meanings based on the context. The writer 
found 9 Assertive which have the functions of stating and informing. There are 13 Directive data which have functions of command, asking, requesting and inviting. 5 expressive which have functions of happy, loving and condoling. 2 Commissive of wishing and refusing. There is 1 Declarative which has function of supporting. 

Keywords: Pragmatics, Speech Act, Illocutionary Act

Topic: Language Acquisition and Education
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Hybrid RF-Solar Energy Harvesting Systems Utilizing Transparent Multiport Micromeshed Antennas

The design of a hybrid radio frequency (RF) and solar energy harvesting (EH) system utilizing a transparent multiport antenna for indoor applications is described. The system incorporates an eight-port transparent antenna, operating in the unlicensed 2.4-GHz band, and is constructed from transparent copper micromeshed planar conductor. The antenna is integrated on the top surface of a solar cell with rectifiers positioned underneath to form a hybrid RF-solar indoor EH system. A key advantage of this approach is that the surface area of the solar cell is reused for the antenna saving space. Another novelty is the use of a multiport antenna for increasing the RF harvested energy. It is demonstrated that with a light intensity of 360 lux, the solar cell can obtain 1.68-mW power while the rectenna can achieve an additional 4.8%-45.8% harvested power when the incident RF input power density is varied from 13.30 to 52.96 mW/m 2 . The transparent antenna achieves 72.4% efficiency and is one of the highest reported results. In addition, the rectifiers obtain 53.2% RF-to-dc conversion efficiency for an RF input power of -10 dBm. These results demonstrate that the proposed RF-solar energy harvester can increase harvested energy and provide energy diversity.

Topic: Energy Harvesting in Wireless Networks
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Long-term follow-up of three controlled trials comparing cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia [letter]

To the Editor:In 1985, we reported the results of three controlled trials comparing the efficacy of cyclosporine versus methotrexate for preventing acute graft-versus-host disease (GVHD) in 179 patients with genotypically HLA-identical marrow grafts for the treatment of acute myelocytic leukemia (AML) in first remission, chronic myelocytic leukemia (CML), or various leukemias in advanced No significant differences were found in the incidence of acute GVHD (40% Y 55%; P = .13),interstitial pneumonia (22% Y 30%; P = .25),and early survival.We updated the results in 1988 and showed that the incidence of chronic GVHD of cyclosporine versus methotrexate-treated patients was also comparable (42% v 48%; P = .67).4The current report updates the results of the three randomized prospective trials performed in Seattle, WA, with follow-ups ranging from 8 to 11 years.The long minimum follow-up permits us to address more definitively the probabilities of leukemic relapse and disease-free long-term survival.One hundred and seventy-nine patients with leukemia were entered into the three trials between September 1, 1980 and December 31, 1983.Study 1 included 56 patients with advanced leukemia, predominantly CML and AML; study 2 consisted of 75 patients with AML in first remission; and study 3 included 48 patients with CML, 41 in chronic phase and 7 in accelerated phase.Details on the courses of these patients before and after transplantation have been p~blished.I-~All received intravenous (IV) cyclophosphamide (60 mg/kg/d x 2) followed by fractionated total body irradiation, 1,200 to 1,575 cGy.GVHD prophylaxis postgrafting was assigned by random permutation of a set of numbers.Methotrexate was administered at a dose of 15 mg/m2 IV on day 1, 10 mg/m2 on days 3,6, and 11, and then once weekly until day 102.Cyclosporine was administered either orally at a dose of 6.25 mg/kg every 12 hours or IV at a dose of 1.5 mg/kg every 12 hours beginning on day -1 until recovery from chemoradiation therapyinduced gastrointestinal toxicity.The full dose of cyclosporine was administered until day 50 unless renal toxicity developed.After day 50, the cyclosporine dose was decreased by 5% per week and prophylaxis stopped 6 months after marrow grafting.

Topic: Hematopoietic Stem Cell Transplantation
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Satisfaction with Taiwan’s medical institutions of research and analysis

Abstract The purpose of this study in a regional teaching hospital external customers (outpatients) against the hospital for registration, inspection items, Payment approved price collar drug program, the overall environment and comprehensive evaluation of satisfaction research and analysis. A cross-sectional random sampling survey to a regional teaching hospital for one month attending look different times the number of research subjects, for 929 copies of valid questionnaires. Northern Alliance in Taiwan medical instrument for the study of customer satisfaction scale. The study mostly to 40–59 year-old, level of education in order to account for the largest university. The results showed that business services provided by hospital satisfaction ranged from an average of no opinion (3 points) to the satisfaction of (4 points) between; overall satisfaction descending order as: the overall environment of medicine procedures collar → consultation between patient check the item price → Payment approved for registration, the customer age and overall satisfaction showed statistically significant difference was (p < .01), Scheffe test found that customers aged 40–59 years old overall satisfaction is higher than 20–39 years of age; customers with the level of education of medical statistics on the overall environment was a significant positive difference (p < .01), Scheffe test found that customers university level of education above the overall environment of the body satisfaction is higher than the country middle school; customers the availability of a work income institutions overall satisfaction showed statistically significant differences (p < .01). Therefore, this study can provide organizations know customer satisfaction with hospital medical institutions to reviewing and improving the environment, and to provide a fit of high public demand for quality medical services.

Topic: Patient Satisfaction in Healthcare
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Guided field Map Estimation and Image Correction for MRI with LargeMagnetic Field Inhomogeneity

Many methods deployed for Magnetic Resonance Imaging (MRI) suffer from degraded image quality when the static magnetic field ($$$B_0$$$) is nonuniform, as $$$B_0$$$ inhomogeneity causes different types of image artifacts and distortions. ﻿Image correction methods require a prior estimate of the field map. In this work, we study the problem of static $$$B_0$$$ inhomogeneity estimation from distorted and undistorted image pairs, despite undistorted images being noisy. The estimated field map is later utilized to correct distorted images. The efficacy of the proposed approach is demonstrated for different encoding methods in the presence of large magnetic field inhomogeneity via extensive simulations.

Topic: Advancements in Photolithography Techniques
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The effects of thiazide diuretics on bone mineral metabolism.

Thiazide diuretics cause changes in calcium metabolism. Clinically, these changes include a decreased excretion of calcium, and in some instances, this results in a corresponding increase in bone mineral. The study of mineral metabolism in bone is difficult because of the slow turnover rate of bone. For this reason, the rat fracture model was used to study bone mineral metabolism in animals given thiazide diuretics. Fifty rats were divided into four groups: group 1 received a fracture of the right tibia and thiazide diuretics, group 2 received thiazide and no fracture, group 3 received no drugs and a fracture, and group 4 received no drugs and no fracture. At the end of 35 days postinjury, all animals were sacrificed. Biochemical and biomechanical results were analyzed, and revealed that animals that received thiazide diuretics and a fracture had the highest bone mineral content.

Topic: Muscle metabolism and nutrition
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Genome-Wide microRNA Expression Profiling in Human Spermatozoa and Its Relation to Sperm Quality

Background: Sperm samples are separated into bad and good quality samples in function of their phenotype, but this does not indicate their genetic quality. Methods: Here, we used GeneChip miRNA arrays to analyze microRNA expression in ten semen samples selected based on high-magnification morphology (score 6 vs. score 0) to identify miRNAs linked to sperm phenotype. Results: We found 86 upregulated and 21 downregulated miRNAs in good-quality sperm (score 6) compared with bad-quality sperm samples (score 0) (fold change &gt; 2 and p-value &lt; 0.05). MiR-34 (FC × 30, p = 8.43 × 10−8), miR-30 (FC × 12, p = 3.75 × 10−6), miR-122 (FC × 8, p = 0.0031), miR-20 (FC × 5.6, p = 0.0223), miR-182 (FC × 4.83, p = 0.0008) and miR-191 (FC × 4, p = 1.61 × 10−6) were among these upregulated miRNAs. In silico prediction algorithms predicted that miRNAs upregulated in good-quality sperm targeted 910 genes involved in key biological functions of spermatozoa, such as cell death and survival, cellular movement, molecular transport, response to stimuli, metabolism, and the regulation of oxidative stress. Genes deregulated in bad-quality sperm were involved in cell growth and proliferation. Conclusions: This study reveals that miRNA profiling may provide potential biomarkers of sperm quality.

Topic: Sperm and Testicular Function
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Molecularly Imprinted Polymers for Stir Bar Sorptive Extraction: Synthesis, Characterization, and Application

Stir bar sorptive extraction is widely used for the preconcentration of organic and inorganic compounds due to its simplicity and versatility. However, commercially available devices are based on nonselective sorbents. Molecularly imprinted polymers provide selective recognition abilities from the template employed during their preparation. In this review, strategies employed for recent for molecularly imprinted polymers employed in stir bar sorptive extraction are described. The advantages and disadvantages are described, as well as future trends involving this preconcentration methodology.

Topic: Analytical chemistry methods development
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Esophago-gastro-duodenoscopy could be an important tool in the diagnostic dilemma inherent in perforated peptic ulcer: A case report

Acute abdomen is a common and sometimes dramatic clinical condition, which can be fatal if diagnosis is not made in time. Perforated peptic ulcer is a cause of an acute abdomen, which can be diagnosed by imaging investigations. However, erect chest X-ray and CT scan may not always establish the diagnosis. Herein we report a case of a patient with acute abdomen, where radiological imaging and CT scan were not able to provide a clear diagnosis. The patient was diagnosed with perforated peptic ulcer by esophago-gastro-duodenoscopy, and underwent laparotomy to repair the anterior wall duodenal perforation with an omental patch. Early endoscopic evaluation seems to be an essential tool for upper gastrointestinal evaluation in acute abdomen cases with inconclusive imaging results.

Topic: Esophageal and GI Pathology
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
The Technical Efficiency of French Regional Airports and Low-Cost Carrier Terminals

In France, the regional airport&amp;rsquo;s demand for services is facing challenges due to the continuous expansion of the high-speed train, high-speed line, and highway networks. This study focuses on the viability of regional airports in France through technical efficiency using data envelopment, principle component analysis, Malmquist productivity index, and regression analysis using bootstrapping. To face the current competitive environment, the regional airports in France adopted strategies, such as the construction of low-cost carrier (LCC) dedicated terminals (LCCTs) with lower expenses to attract more LCCs, increasing non-aeronautical revenue, and hosting regional hubs of LCCs. This is the first study that analyzes all of the French regional airports. The findings indicate that the existence of LCCTs positively affects technical efficiency on the airport&amp;rsquo;s performance, and share of LCCs at a regional airport leads to neither the efficiency nor the profit level.

Topic: Aviation Industry Analysis and Trends
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Robustness of Anytime Bandit Policies

This paper studies the deviations of the regret in a stochastic multi-armed bandit problem. When the total number of plays n is known beforehand by the agent, Audibert et al. (2009) exhibit a policy such that with probability at least 1-1/n, the regret of the policy is of order log(n). They have also shown that such a property is not shared by the popular ucb1 policy of Auer et al. (2002). This work first answers an open question: it extends this negative result to any anytime policy. The second contribution of this paper is to design anytime robust policies for specific multi-armed bandit problems in which some restrictions are put on the set of possible distributions of the different arms.

Topic: Auction Theory and Applications
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
The Right Design of Supply Chain: Examples

AbstractThe following sections are included:Design the Right Supply ChainResponsive Supply Chain in Manufacturing IndustryResponsive supply chain and fast clock-speed product – Personal computerResponsive supply chain and medium clock-speed product – Automobile industryResponsive supply chain and slow clock-speed product – Commercial aircraftEfficient Supply Chain in Manufacturing IndustryEfficient supply chain and fast clock-speed product – Apparel industryEfficient supply chain and medium clock-speed product – Beer industryEfficient supply chain and slow clock-speed product – Steel industryService IndustryThe book industry – Amazon.comThe retail industry – Wal-MartSynchronizing Supply ChainLink manufacturer to retailer – HP and Wal-MartLinking suppliers to manufacturers – CovisintLessons to LearnRetail industry – K-MartPC industry – IBMSummaryQuestions for PonderingReferences

Topic: Quality and Supply Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
CCDC 2202321: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Sound in ecclesiastical spaces in Cordoba. Architectural projects incorporating acoustic methodology (El sonido del espacio eclesial en Cordoba. El proyecto arquitectonico como procedimiento acustico)

This thesis is concerned with the acoustic analysis of ecclesiastical spaces, and the subsequent implementation of acoustic design methodology in architectural renovations. One begins with an adequate architectural design of specific elements (shape, materials, and textures), with the intention of elimination of acoustic deficiencies that are common in such spaces. These are those deficiencies that impair good speech intelligibility and good musical audibility. The investigation is limited to churches in the province of Cordoba and to churches built after the reconquest of Spain (1236) and up until the 18th century. Selected churches are those that have undergone architectural renovations to adapt them to new uses or to make them more suitable for liturgical use. The thesis attempts to summarize the acoustic analyses and the acoustical solutions that have been implemented. The results are presented in a manner that should be useful for the adoption of a model for the functional renovation of ecclesiastical spaces. Such would allow those involved in architectural projects to specify the nature of the sound, even though somewhat intangible, within the ecclesiastical space. Thesis advisors: Jaime Navarro and Juan J. Sendra Copies of this thesis written in Spanish may be obtained by contacting the advisor, Jaime Navarro, E.T.S. de Arquitectura de Sevilla, Dpto. de Construcciones Arquitectonicas I, Av. Reina Mercedes, 2, 41012 Sevilla, Spain. E-mail address: jnavarro@us.es

Topic: Noise Effects and Management
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences