jimnoneill/paper-to-field-training huggingface dataset:
Image2_Application of an angiogenesis-related genes risk model in lung adenocarcinoma prognosis and immunotherapy.tif

&lt;p&gt;Lung adenocarcinoma (LUAD) is an essential pathological subtype of non-small cell lung cancer and offers a severe problem for worldwide public health. There is mounting proof that angiogenesis is a crucial player in LUAD progression. Consequently, the purpose of this research was to construct a novel LUAD risk assessment model based on genetic markers related to angiogenesis. We accessed The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases for LUAD mRNA sequencing data and clinical information. Based on machine algorithms and bioinformatics, angiogenic gene-related risk scores (RS) were calculated. Patients in the high-risk category had a worse prognosis (p &lt; 0.001) in the discovery TCGA cohort, and the results were confirmed by these three cohorts (validation TCGA cohort, total TCGA cohort, and GSE68465 cohort). Moreover, risk scores for genes involved in angiogenesis were independent risk factors for lung cancer in all four cohorts. The low-risk group was associated with better immune status and lower tumor mutational load. In addition, the somatic mutation study revealed that the low-risk group had a lower mutation frequency than the high-risk group. According to an analysis of tumor stem cell infiltration, HLA expression, and TIDE scores, the low-risk group had higher TIDE scores and HLA expression levels than the high-risk group, and the amount of tumor stem cell infiltration correlated with the risk score. In addition, high-risk groups may benefit from immune checkpoint inhibitors and targeted therapies. In conclusion, we developed an angiogenesis-related gene risk model to predict the prognosis of LUAD patients, which may aid in the classification of patients with LUAD and select medications for LUAD patients.&lt;/p&gt;

Topic: Actinomycetales infections and treatment
Subfield: Microbiology
Field: Medicine
Domain: Health Sciences
Bayesian reference analysis for proportional hazards model of random censorship with Weibull distribution

This article deals with the objective Bayesian analysis of random censorship model with informative censoring using Weibull distribution.The objective Bayesian analysis has a long history from Bayes and Laplace through Jeffreys and is reaching the level of sophistication gradually.The reference prior method of Bernardo is a nice attempt in this direction.The reference prior method is based on the Kullback-Leibler divergence between the prior and the corresponding posterior distribution and easy to implement when the information matrix exists in closed-form.We apply this method to Weibull random censorship model and compare it with Jeffreys and maximum likelihood methods.It is observed that the closed-form expressions for the Bayes estimators are not possible; we use importance sampling technique to obtain the approximate Bayes estimates.The behaviour of maximum likelihood and Bayes estimators is observed via extensive numerical simulation.The proposed methodology is used for the analysis of a real-life data for illustration and appropriateness of the model is tested by Henze goodness-of-fit test.

Topic: Data-Driven Disease Surveillance
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
The K-~+7:-d and K-~+Tc-n Final States in K-d Interactions

were studied in the 30in. MURA bubble chamber. The cross-sections were (130 :~ 30) and (1530 :~ 180) ~b respectively. The final state K-=+=-d was found to be dominated by K*(890) production, while the final state K-~+~-n proceeded substantially through the production of the double resonances K*°(890) A-(1236). The coherent reaction agrees fairly we]l with a multiperipheral model. The decay density matrix elements are presented in both the Gottfried-Jackson and helicity frames.

Topic: Quantum Chromodynamics and Particle Interactions
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Magnetism, muteness, magic Spectacle and the Parisian lyric stage c1830

&lt;p&gt;This study explores four works staged at the Paris Opera between 1827 and 1831 in a theatrical context. After an introductory chapter, in which the importance of &lt;i&gt;spectacle&lt;/i&gt; to the Parisian public is considered, and the theatrical and critical context for my study is set out, there is a short chapter that considers a conspicuous failure at the Opera: Chelard's &lt;i&gt;Macbeth&lt;/i&gt; (1827), which attempted to break new ground, but was criticised for the mishandling of its melodramatic subject. In the second chapter the &lt;i&gt;ballet-pantomime La Somnambule&lt;/i&gt; (1827) is examined, together with the general representation of sleepwalking in a number of works at the secondary theatres, against the background of the growing interest in the phenomenon of magnetism. Chapter Three deals with the interest in mute heroines surrounding the premiere of Auber's opera &lt;i&gt;La Muette de Portici&lt;/i&gt; (1828). A consideration of works staged at the secondary theatres reveals both the difficulties and the potential in the representation of communication through mime and music and provides a context in which to assess the opera.&lt;/p&gt;&lt;p&gt;The final chapter traces the fortunes of &lt;i&gt;Faust&lt;/i&gt; in Paris from 1823, the year that saw the first translations of Goethe's work into French, to 1831, when the Opera staged its phenomenally successful Faustian opera &lt;i&gt;Robert le diable&lt;/i&gt;. The intervening years saw a number of adaptations of the legend as operas and &lt;i&gt;mélodrames&lt;/i&gt;, and this chapter suggests how the Opera absorbed elements of these versions of Goethe and transformed them. In short, these works illustrate the relation between high and low culture, music and &lt;i&gt;mise en scène&lt;/i&gt;, creation and reception. The dissertation as a whole both helps to explain the emergence of &lt;i&gt;grand opéra&lt;/i&gt; and its impact on later European music theatre, and provides an insight into the expectations of audiences and critics at the end of Bourbon Restoration in Paris.&lt;/p&gt;

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Self-Reported Physical Activity of High School Students in Southern Maine

Knowledge of high school students’ physical activity (PA) can assist in identifying areas of programmatic need within physical education (PE) and for out of school programs. PURPOSE: The purpose of this study was to assess the PA levels and patterns of high school students in southern Maine. METHODS: Participants were 142 students (86 females, 56 males) from 4 high schools in southern Maine (one urban, one suburban, two rural). Mean age was 14.9 years with 87% of the sample in grade 9. The validated Physical Activity Questionnaire for Adolescents (PAQA) was used in this study to assess PA. The PAQA asks participants to recall their PA during the previous 7 days. Surveys were administered to students enrolled in PE and were part of a larger study examining attitudes toward PA and PE. RESULTS: Mean overall score for the PAQA was 2.62+0.60 (1=low PA, 5=high PA), with a range of 1.18 to 4.29. Males were slightly more active than females overall (2.75+0.72 vs 2.53+0.66, p=0.068) and reported more PA during evenings (2.96+1.37 vs 2.50+1.29, p=0.044) and the weekend (2.70+1.08 vs 2.32+1.00, p=0.036). Students in urban (3.98+0.81) and suburban schools (4.30+0.76) reported significantly greater activity in PE classes than rural students (3.54+0.86) (p=<0.05) while students in rural schools (1.65+ 1.23) reported greater activity during lunch than urban (1.23+0.43) and suburban students (1.12+0.39) (p=<0.05). Jogging, walking, basketball, and soccer were the most cited activities overall. Females preferred walking, jogging, dance and skipping rope while males preferred jogging, basketball, walking and soccer. Overall, 10% reported daily activity while 14% reported no activity. In PE, 73% reported doing vigorous activity quite often. At lunch, 80% reported sitting. After school, 46% were very active while 28% reported no activity. During evenings, 29% reported being very active while 29% reported no activity. Over the weekend, 52% reported being very active 2 or more times, with 21% reporting no activity. CONCLUSIONS: These findings provide information on high school students’ PA from a sample of southern Maine schools. In addition to PA levels and patterns, knowledge of student preferences for PA would help in PA program development both in PE and for out of school programs.

Topic: Children's Physical and Motor Development
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Assessment of Response to Treatment in Vulvar Vestibulitis Syndrome by Means of the Vulvar Algesiometer

Am J Obstet Gynecol 1999;181(1):99–102 A pilot study investigates the vulvar algesiometer in correlating symptom improvement with treatment response in vulvar vestibulitis syndrome. Women with vulvar vestibulitis syndrome attending a specialist vulvar clinic were assessed with the algesiometer before and after treatment. The conditions of 25 patients had improved to the point of discharge. Readings before and after treatment were compared. There was statistically significant difference in the vulvar algesiometer readings before and after treatment and this improvement was reflected in patient response. Nine patients had no response to treatment and also no significant improvement in vulvar algesiometer score. The vulvar algesiometer provides an easy noninvasive means of assessing vestibular tenderness. It is well tolerated by the patients and provides a degree of biofeedback for them. Editorial Comment: The understanding of vulvar vestibulitis has been hampered by the subjective nature of the clinical syndrome. Importantly, this new technique is a quantitative method for assessing vulvar pain on vestibular touch. It is a noninvasive method of assessing the quantified vestibular tone to assess response to treatment. It should be simple to use and gives recorded results, which may be important in long-term assessment of treated patients. (LBT)

Topic: Sexual function and dysfunction studies
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Iatrogenic injuries of peripheral nerves

In this study, we discuss 68 cases in which peripheral nerve trunks were inadvertently divided by surgeons. Most of these accidents occurred in the course of planned operations. Delay in diagnosis and in effecting repair was common. We list the nerves particularly at risk and the operations in which special care is needed. We recommend steps to secure prompt diagnosis and early treatment.

Topic: Nerve Injury and Rehabilitation
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
ECONOMIC POLICY UNCERTAINTY INDEX MEETS ENSEMBLE LEARNING

We utilize two specific ensemble learning methods (ensemble linear regression model (LM) and random forest (RF)), in a data-rich environment of the Newsbank media database to scrutinize the possibilities of enhancing the predictive accuracy of Economic Policy Uncertainty (EPU) index.LM procedure mostly outperforms both RF-based assessments and the original EPU index.We find that our LM estimate behaves more like an uncertainty indicator that the RF-based uncertainty or the original EPU index.It is strongly correlated to other standard uncertainty proxies, it is more countercyclical, and it has more pronounced leading properties.Finally, we considerably widen the scope of search terms included in the calculation of EPU index.We find that the predictive precision of EPU index can be considerably increased using a more diversified set of uncertainty-related terms than the original EPU framework.

Topic: Market Dynamics and Volatility
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Dietary fat and body weight control

Abstract The global obesity epidemic has heightened the debate about dietary factors contributing to weight gain. Media stories have promulgated the notion that obesity has increased despite reductions in dietary fat intake. Some have even speculated that lower dietary fat levels may be driving the rapid rise in weight gain within the population. A close examination of the science reveals a different picture and supports the hypothesis that dietary fat, within the context of the total dietary composition consumed by many populations, promotes obesity. Hence, dietary fat control is still an important strategy as part of an overall approach to body weight management in our modern environment. Dietary fat increases the energy density of foods. Abundant evidence from preclinical and clinical studies indicates that fat promotes excess energy intake and positive energy balance. Dietary fat does not promote its own oxidation in the body and is stored efficiently, promoting a positive fat balance. Thus, both the behavioral and metabolic responses to dietary fat increase the probability of positive energy balance and body fat gain. Restoring fat balance when consuming diets rich in fat requires increasing the size of the body fat mass, increasing physical activity, or reducing dietary fat intake. Numerous epidemiologic, preclinical, and controlled clinical studies have shown that body fat is positively associated with dietary fat intake and that dietary fat manipulation leads to appropriate changes in body fat mass. Finally, data from the National Weight Control Registry, a database of &gt;3000 individuals who have successfully maintained a substantial weight loss, indicate that moderating dietary fat intake is a key strategy for long‐term management of body weight.

Topic: Adipose Tissue and Metabolism
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application

Purpose: To investigate the protective effects of vitamin A palmitate and carbomer gel on the morphology of conjunctival epithelium and density of goblet cells (GCs) in patients on long-term prostaglandin analogs (PGAs) application. Methods: In this prospective cohort study, 23 primary open-angle glaucoma patients and 7 normal-tension glaucoma patients prescribed PGAs for &gt;1 year were enrolled into 3 identical clinical trials and randomized into 3 groups (10 per group). Patients were treated twice daily with vitamin A palmitate eye gel 0.1%, or carbomer eye gel 0.2%, or no additional application of these 2 drugs. Ocular surface disease index questionnaires, Schirmer 1 test without anesthesia, tear break-up time test, and GCs density assessment by in vivo confocal microscopy and conjunctival impression cytology analysis were performed at baseline and at months 1, 3, and 6 of the study. Results: Both vitamin A palmitate and carbomer gel led to a significant improvement in ocular surface disease index questionnaires score and prevented the gradual decline in tear break-up time. Vitamin A palmitate significantly increased the GC density after treatment. The GC density assessed by in vivo confocal microscopy positively correlated with that measured by conjunctival impression cytology. Conclusions: Vitamin A palmitate and carbomer eye gel can effectively relieve dry eye symptom caused by long-term application of PGAs by increasing the GCs density and thereby reducing the toxicity to the conjunctiva. Vitamin A palmitate and carbomer eye gel may be valuable alternatives for glaucoma patients who prescribed long-term PGAs.

Topic: Glaucoma and retinal disorders
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
OCCURRENCE OF DEPRESSION IN THE PATIENTS SUFFERING FROM CHRONIC INFECTION OF HEPATITIS C VIRUS

<strong><em>Objectives: </em></strong><em>The aim of this research work is to find out the rate of occurrence of depression in the patients suffering from chronic HCV infection prior to interferon treatment utilizing the CES-D questionnaire.</em> <strong><em>Methodology: </em></strong><em>The positive patients for antibodies of hepatitis C virus with the utilization of the EIA for duration of more than six months and who did not obtain interferon treatment were the part of this research work after giving their written consent. The patients who were suffering from co-existing infections like hepatitis B &amp;D virus or HIV virus, or the patients available with other co-occurring liver diseases as cirrhosis, auto-immune hepatitis and Wilson disease were not the part of this research work. CES-D in Urdu version managed to collect the information. Ascore of greater than ten was the standard for consistent with the availability of depression.</em> <strong><em>Results: </em></strong><em>Total 96 patients were the part of this research work in which 59.40% patients were available with depression. There were 57.90%males &amp;42.10% females in this research work. We saw the high occurrence in the under-graduate’s students &amp; there was a positive association with the duration of the HCV infection. </em> <strong><em>Conclusions: </em></strong><em>The findings of this research work showed that 59.40% patients suffering from HCV infection were available with depression before the start of therapy it necessary to assess and treat this issue before the start of the interferon treatment. </em> <strong><em>KEY WORDS: </em></strong><em>Interferon, Treatment, Utilization, HCV Infection, Depression, EIA.</em>

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Short Communication Genotypic Diversity, Antibiotic Resistance and Bacteriocin Production of Enterococci Isolated from Rhizospheres

This study aimed to identify and to characterize rhizospheric-derived enterococci. The results showed the prevalence of Enterococcus faecium species (97%) vs. Enterococcus durans (3%). Susceptibility testing for antibiotics showed a low percentage of resistance to erythromycin (3.2%) and tetracycline (11.2%), and intermediate resistance to vancomycin (6.5%). Nevertheless, a high proportion of bacteriocin production was recorded. Furthermore, PCR detection of antibiotic resistance and bacteriocin production-encoding genes was investigated. Pulsed-field gel electrophoresis typing (PFGE) showed a great variability of enterococci in the rhizosphere. Moreover, mutilocus-sequence-typing analysis (MLST) revealed the identification of three new sequence types (STs), which were registered as ST613, ST614 and ST615. Key words: Enterococci, antibiotic resistance, bacteriocins, MLST, PFGE Soil is a vast reservoir for microorganisms. Many bacteria have been found in soils, especially in the rhizosphere, and the abundance in vegetated soils is due to the availability of nutrients via plant roots and to the diversity of ecological niches (16). Enterococcus spp. colonizes the gastrointestinal tract of many animals and is also commonly found in soil, plants,

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Gastric acid hypersecretion in short bowel syndrome in infants: association with extent of resection and enteral feeding.

To determine the frequency of gastric acid hypersecretion in infants with chronic malabsorption due to short bowel syndrome, acid secretory function was determined in 23 infants with malabsorption 2-22 months following small bowel resection and in a control group of 14 chronically ill, age- and weight-matched infants who did not undergo bowel resection. The prevalence of basal acid hypersecretion (defined as acid output 2 SD above the mean for the control group) was 17% (4 of 23). Basal gastric acid hypersecretion was associated with two factors: massive small bowel resection and initiation of enteral feeding. Basal acid hypersecretion was present on the initial study in 3 of 7 infants with less than one-third of the small bowel remaining, but in only 1 of 16 with more than one-third intact (p less than 0.05). Hypergastrinemia was present in 3 of 6 infants following massive bowel resection, but in only 1 of 15 with more than one-third intact (p less than 0.05), but hypergastrinemia was not consistently associated with hypersecretion. In each of six previously unfed infants, a trial of enteral feeding resulted in increased basal and maximal acid output. Three infants developed basal acid hypersecretion during initiation of enteral feeding. There was no evidence of pentagastrin-stimulated maximal acid hypersecretion in any of the infants.

Topic: Clinical Nutrition and Gastroenterology
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
An Influence of Digitalization and Recent Innovations on the Hospitality and Tourism Sector

Our lifestyle cravings are voracious. The hospitality sector ensures guests are pleased with every new application and connected system that continues to become a business success. For guests, digital technology means a simple life where customer service is all about it. The transition of hospitality is at its tilt stage where everything is possible due to digital technology, where the ability to be improved by the correct technique from the movement of the reservation to check-out and from the ease of connecting to the hotel guest network to the temperature of the guest room when entering for the first time. Therefore, advancement in emerging technologies provides an opportunity for the hospitality business. Hotels strive for their growth to have more guest satisfaction with better experience, provisions, and management.

Topic: Digital Marketing and Social Media
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Solid film lubricants and thermal control coatings flown aboard the EOIM-3 MDA sub-experiment

Additional experimental data were desired to support the selection of candidate thermal control coatings and solid film lubricants for the McDonnell Douglas Aerospace (MDA) Space Station hardware. The third Evaluation of Oxygen Interactions With Materials Mission (EOIM-3) flight experiment presented an opportunity to study the effects of the low Earth orbit environment on thermal control coatings and solid film lubricants. MDA provided five solid film lubricants and two anodic thermal control coatings for EOIM-3. The lubricant sample set consisted of three solid film lubricants with organic binders one solid film lubricant with an inorganic binder, and one solid film lubricant with no binder. The anodize coating sample set consisted of undyed sulfuric acid anodize and cobalt sulfide dyed sulfuric acid anodize, each on two different substrate aluminum alloys. The organic and inorganic binders in the solid film lubricants experienced erosion, and the lubricating pigments experienced oxidation. MDA is continuing to assess the effect of exposure to the low Earth orbit environment on the life and friction properties of the lubricants. Results to date support the design practice of shielding solid film lubricants from the low Earth orbit environment. Post-flight optical property analysis of the anodized specimens indicated that there were limited contamination effects and some atomic oxygen and ultraviolet radiation effects. These effects appeared to be within the values predicted by simulated ground testing and analysis of these materials, and they were different for each coating and substrate.

Topic: Hydrogen embrittlement and corrosion behaviors in metals
Subfield: Metals and Alloys
Field: Materials Science
Domain: Physical Sciences