jimnoneill/paper-to-field-training huggingface dataset:
Water-Soluble Conjugated Oligomers:  Effect of Chain Length and Aggregation on Photoluminescence-Quenching Efficiencies

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTWater-Soluble Conjugated Oligomers: Effect of Chain Length and Aggregation on Photoluminescence-Quenching EfficienciesBrent S. Gaylord, Shujun Wang, Alan J. Heeger, and Guillermo C. BazanView Author Information Departments of Chemistry and Materials University of California, Santa Barbara, California 93106 Cite this: J. Am. Chem. Soc. 2001, 123, 26, 6417–6418Publication Date (Web):June 8, 2001Publication History Received12 February 2001Published online8 June 2001Published inissue 1 July 2001https://pubs.acs.org/doi/10.1021/ja010373fhttps://doi.org/10.1021/ja010373frapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views2524Altmetric-Citations224LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conjugated polymers,Differential thermal analysis,Fluorescence,Quenching,Surfactants Get e-Alerts

Topic: Luminescence and Fluorescent Materials
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Real-world effectiveness and safety of nirsevimab, RSV maternal vaccine and RSV vaccines for older adults: a living systematic review and meta-analysis

Background The long-acting monoclonal antibody nirsevimab and respiratory syncytial virus (RSV) vaccines became available for prevention of severe RSV-associated disease in 2023. While clinical trials showed good efficacy and safety, their restrictive inclusion criteria, small sample sizes and short follow-up limit generalisability. We aimed to summarise real-world evidence on the effectiveness and safety of nirsevimab, RSV maternal vaccine and RSV vaccines for older adults. Methods A living systematic review and meta-analysis, with 5 monthly updated searches in three databases was performed. Eligible studies were published from 1 December 2022 to 10 March 2025. Meta-analyses for the effectiveness of nirsevimab and RSV vaccines were carried out using random-effects model. Safety data were summarised narratively. Results A total of 50 publications, covering approximately 7.6 million people, were included. Nirsevimab showed 80.7% effectiveness (95% CI: 75.7% to 85.7%; seven studies) against RSV-related emergency department visits, 80.7% (95% CI: 76.1% to 85.2%; 17 studies) against hospital admissions and 75.6% (95% CI: 63.3% to 87.9%; eight studies) against intensive care unit admissions. The effectiveness of RSV vaccines for older adults against RSV-related hospital admissions was 79.6% (95% CI: 73.8% to 85.3; three studies). No effectiveness data were available for RSV maternal vaccine. No severe adverse events were reported for nirsevimab, while RSV vaccines in older adults had fewer than 10 Guillain-Barré syndrome cases per million doses. No severe adverse events were reported for RSV maternal vaccine, although evidence was limited. Conclusions Our review demonstrated high effectiveness of nirsevimab in reducing RSV-related healthcare utilisation in infants and a favourable safety profile. More evidence is needed for evaluating RSV vaccines in pregnant people and older adults. PROSPERO registration number CRD42025643585.

Topic: Respiratory viral infections research
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Optimized Plant Disease Prediction using CNN and Fertilizer Recommendation Engine

A large portion of the Indian economy depends on agricultural productivity, and the impact of plant diseases can be significant. The consequences of a plant being affected by a disease can result in a considerable decrease in output, and the experiencing decline in financial losses is a unique consequence of a decline in both the caliber and amount of agricultural goods. To avoid a reduction in agricultural productivity and quantity, it is essential to recognize plant diseases. While enormous acres of crops are being monitored, plant disease detection is receiving an increasing amount of attention. Thus, this is possible by making use of image processing methods for plant disease diagnosis. The major limitation of the existing system is, it only predicts a plant disease, and this work not only detects the plant disease but also recommends a suitable fertilizer. The dataset used in the proposed model contains 16870 images and the model is implemented using a deeper Convolutional Neural Network (CNN). The level of accuracy accomplished by the model is 96% for fruit leaves and 89% for vegetable leaves.

Topic: Smart Agriculture and AI
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells

<title>Abstract</title> Myeloid malignancies with <italic>DDX41</italic> mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the mechanisms underlying these specific conditions remain elusive. Here, we demonstrate that loss of DDX41 function impairs efficient RNA splicing, resulting in DNA replication stress with excess R-loop formation. Mechanistically, DDX41 binds to the 5ʹ splice site (5ʹSS) of coding RNA and coordinates RNA splicing and transcriptional elongation; loss of DDX41 prevents splicing-coupled transient pausing of RNA polymerase II at 5ʹSS, causing aberrant R-loop formation and transcription-replication collisions. Although the degree of DNA replication stress acquired in S phase is small, cells undergo mitosis with under-replicated DNA being remained, resulting in micronuclei formation and significant DNA damage, thus leading to impaired cell proliferation and genomic instability. These processes may be responsible for disease phenotypes associated with <italic>DDX41</italic> mutations.

Topic: RNA Research and Splicing
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
European Film Noir

The most transnational of genres, film noir is nonetheless, as Andrew Spicer points out in his introduction to European Film Noir, hailed as a quintessentially American genre. While the French and British traditions of noir cinema have gained some recognition recently (not least through citation by contemporary American filmmakers), there has been little comprehensive study of non-American film noir. This collection goes a long way to fill this gap, and to establish European cinema not merely as a provider of early references to what was to become an American canon, but as the site of diverse film noir traditions in their own right. Bringing together key specialists, this collection provides diachronic studies of French, British, German, Spanish and Italian cinemas. Ginette Vincendeau offers a typically captivating account of film noir as a French tradition, weaving together an investigation of the historical context with a revealing analysis of key thematic and stylistic elements. She traces this tradition back to nineteenth-century French literature, and links its development in film form to the success of the hard-boiled American novel (translated for the famous Série noire paperback series that gave its name to the genre) as well as French crime writers – Simenon in particular.

Topic: Cinema and Media Studies
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Effect of the fixed combination of irbesartan 300 mg/hydrochlorothiazide 25 mg on the circadian blood pressure profile in essential hypertension

Most hypertensive patients included in morbidity and mortality trials needed two or more drugs to achieve a sustained blood pressure reduction. Therefore, safe combinations using higher doses of antihypertensive drugs are frequently required to control blood pressure. The aim of the present study is to evaluate the magnitude of the effect of a once-daily fixed combination of irbesartan 300/hydrochlorothiazide 25 mg on the circadian blood pressure profile in essential hypertensive patients not controlled with full-dose single therapy or low-dose combined therapy. After a 1-week wash-out period, 57 patients (28m, 29f) aged 45-78 years showing a mean daytime-BP (from 10:00 to 20:00 hours) higher than 135/85 mmHg were treated with irbesartan 300/HCTZ 25 for 12 weeks. Twenty-four hour ambulatory blood pressure monitoring (ABPM) was performed at the end of the wash-out period and during the last week of treatment. After treatment a significant reduction in the average values of both clinic and ambulatory BP values was observed in the whole group of 57 patients (from 146.0± 11.0 to 123.3± 13.3 mmHg, p<0.001 for 24-h SBP; and from 89.8± 8.2 to 76.5± 9.4 mmHg, p< 0.001 for 24-h DBP). The response rate was 94.7% (ABPM lowering > 5 mmHg of either 24h-SBP or 24h-DBP values) and the control rate 68.4% (daytime BP< 135/85 mmHg) at the end of treatment. The average lowering of ambulatory SBP and DBP at peak was 25.2± 14.5 and 14.7± 9.5, respectively, whereas the lowering at trough was 22.3± 18.3 and 12.3± 10.9 mmHg, respectively. The trough-to-peak ratio (T/P) of the group was 0.92 for SBP (0.97 in responders) and 0.84 for DBP (0.89 in responders). The smoothness index (SI) calculated as the average of all individual values was 1.66± 1.0 for SBP (1.76± 0.9 in responders) and 1.29± 0.8 for DBP (1.48± 0.6 in responders). Only 7 side effects in 6 patients were reported. No metabolic changes were observed and no patient discontinued the study. The fixed combination of irbesartan 300/HCTZ 25 administered once-daily was very effective in reducing 24-hour blood pressure and very well tolerated, preserving the circadian profile as showed by T/P ratios very close to 1 and SI > 1 for both SBP and DBP.

Topic: Blood Pressure and Hypertension Studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Omni-Channel Retailing : Blurring the lines between online and offline

Background Omni-channel retailing has developed as an extension of multi-channel retailing. The difference between the concepts is the level of integration, where an omni-channel requires seamless and complete channel integration compared to a multi-channel where the level of integration varies from non-existing to high. Today’s customers expect an integrated shopping experience where they can combine the different channels according to their preferences and omni-channel is a way for retailers to meet this need. Purpose The purpose of this thesis is to explore the concept of omni-channel retailing and its implementation in retail firms operating in the Swedish market. Method This study is based on an interpretive approach and takes the form of an exploratory multiple case study through the investigation of four retailers. Qualitative data was collected through semi-structured interviews and the findings were analyzed abductively. Conclusion The conclusion of this thesis is that the investigated retailers still have, more or less, a long way to go in their integrative efforts. The retailer that has come the furthest in their effort has only implemented nine out of fifteen omni-channel criteria. Three main incentives for implementing an omni-channel strategy were identified. These are to respond to customer demands, to optimize the individual sales channels and to gain a competitive advantage. Additionally, several challenges arise as the retailer moves towards an omni-channel. These include technological investments, change management, channel conflict, return management and consistency. Furthermore, five potential sources of these challenges were identified as technological requirements, organizational changes, sales accreditation policies, in-store returns and finally the franchise business model.

Topic: Consumer Retail Behavior Studies
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
Identification of the Schistosoma mansoni Molecular Target for the Antimalarial Drug Artemether

Plasmodium falciparum and Schistosoma mansonii are the parasites responsible for most of the malaria and schistosomiasis cases in the world. Notwithstanding their many differences, the two agents have striking similarities in that they both are blood feeders and are targets of an overlapping set of drugs, including the well-known artemether molecule. Here we explore the possibility of using the known information about the mode of action of artemether in Plasmodium to identify the molecular target of the drug in Schistosoma and provide evidence that artemether binds to SmSERCA, a putative Ca²⁺-ATPase of Schistosoma . We also predict the putative binding mode of the molecule for both its Plasmodium and Schistosoma targets. Our analysis of the mode of binding of artemether to Ca²⁺-ATPases also provides an explanation for the apparent paradox that, although the molecule has no side effect in humans, it has been shown to possess antitumoral activity.

Topic: Malaria Research and Control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen

Significance IgE antibody interaction with allergen proteins is the main driver for life-threating allergic responses. Using a nanoparticle-based method, we identified the most crucial binding sites for IgEs on peanut proteins by testing a small population of patient serum with a clinical history of severe allergies to peanuts. We then synthesized inhibitors, we call covalent heterobivalent inhibitors, which specifically and permanently prevent IgEs from binding to peanut proteins and triggering allergic responses. This is significant as it seems that only a few binding sites on peanut allergen proteins drive allergic responses. Also, this is a functional example of selective IgE inhibition to a relevant food allergen and establishes cHBIs as a class of allergy therapeutics.

Topic: Food Allergy and Anaphylaxis Research
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Analysis of Lateral Maneuver‐Induced Lift Loss of Navy Fighter/Attack Aircraft During Approach to Carrier

Abstract The purpose of this analysis was to provide guidance to designers of future tactical Navy aircraft on one aspect of carrier suitability that has contributed to the operational success of the F‐14 and F/A‐18 in carrier operations. Specifically, the ability of both of these aircraft to perform aggressive lateral maneuvers to capture desired glide path, without excessive altitude loss, has contributed to the favorable carrier suitability characteristics of each aircraft. The intent of this analysis was to quantify lift and altitude loss for the F‐14 and F/A‐18 due to lateral maneuvers in the lineup correction task, and determined the causes and components of the lift loss. A secondary intent was to determine whether the amount of lift loss due to lateral maneuvers was a good indicator of an aircraft's ability to execute precise flight path control with minimum pilot workload. Twenty‐six offline simulations of F‐14B and F/A‐18C aircraft, conducted at Manned Flight Simulator at the Naval Air Warfare Center Aircraft Division in Patuxent River, MD, provided the raw data for the analysis. Results and conclusions on the causes and components of lift loss and subsequent altitude loss associated with the 26 simulations were drawn, and where applicable, comparisons between F‐14 and F/A‐18 were made.

Topic: Aerospace and Aviation Technology
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Supplementary Figure 1 from Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells

Supplementary Figure 1 from Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells

Topic: RNA Interference and Gene Delivery
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Flora of Ceará, Brazil: Onagraceae

Abstract This study aimed to provide the floristic survey of Onagraceae in Ceará state. The floristic study consisted of analyzing material deposited in the herbaria EAC, ESA, FUEL, HCDAL, HUEFS, HUVA, HVASF, INPA, K, MO, NY, P, RB, UFRN and US, as well as field work carried out between 2015 and 2017. In the study area, Onagraceae is represented by the genus Ludwigia, and seven species were recorded: L. erecta, L. helminthorrhiza, L. hyssopifolia, L. leptocarpa, L. nervosa, L. octovalvis and L. tomentosa. All seven species were also sampled in Conservation Units, with L. erecta recorded in six of them. L. erecta and L. helminthorrhiza have a broader distribution in the state. L. nervosa and L. tomentosa are indicated as new occurrences for Ceará, both with only one record in the south of the state, expanding their range in Northeastern Brazil. The information in this manuscript allows identification of Onagraceae representatives in Ceará state, through morphological descriptions, identification keys, taxonomic comments, illustrations, photographs and geographic distribution data.

Topic: Plant Diversity and Evolution
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The North Calotte Committee

The North Calotte has been an area of priority in Nordic cross-border co-operation. Resources from the Nordic Council of Ministers and the Nordic Committee of Nordic Senior Officials for Regional Policy have been channelled into regional development via the North calotte Committee. The processes of change and the emergence of new priorities at the international, national and regional levels have created new opportunities, particularly in the North calotte area. North Calotte co-operation aims at promoting economic development and raising the general level of skills in the region. The challenges to further development of the North Calotte include a hard climate, a vulnerable nature, large distances, and a very low population density. The over-riding goal of the North Calotte Committee is to contribute to the development of the region into a functional region in Europe. The general goal for cultural co-operation is to increase consciousness as regards the importance of culture for regional development and identity.

Topic: Regional Development and Policy
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
A revision of the South American species of the ant genus Probolomyrmex (Hymenoptera: Formicidae).

This dataset contains the digitized treatments in Plazi based on the original journal article Agosti, D. (1995): A revision of the South American species of the ant genus Probolomyrmex (Hymenoptera: Formicidae). Journal of the New York Entomological Society 102: 429-434, URL: http://research.amnh.org/entomology/social_insects/ants/publications/8080/8080.pdf

Topic: Insect and Arachnid Ecology and Behavior
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
7 dB quadrature squeezing at 860 nm with periodically-poled KTiOPO4

We observed -7.2 dB quadrature squeezing at 860 nm by using a sub-threshold continuous-wave pumped optical parametric oscillator with a periodically-poled KTiOPO4 crystal as a nonlinear optical medium. The squeezing level was measured with the phase of homodyne detection locked at the quadrature. The blue light induced infrared absorption was not observed in the experiment.

Topic: Photorefractive and Nonlinear Optics
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Special Issue on Toxicologic Neuropathology of the Peripheral Nervous System: A Special Compendium of Past, Present, and Future Developments in a Neglected Field

Neuropathology of the peripheral nervous system (PNS) is an underappreciated area in toxicologic pathology. Toxicity to nerves and ganglia can result from toxic insults following exposure to environmental, occupational, and industrial chemicals; drugs and biologics; cosmetics and food additives; and even physical agents such as noise. The following introduction provides an overview of this special issue of Toxicologic Pathology on toxicologic neuropathology of the PNS and highlights the range of key topics in this field that are reviewed in this compilation.

Topic: Immunotoxicology and immune responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Mast cell–mediated inflammatory responses require the α2β1 integrin

Abstract Although the α2β1 integrin is widely expressed and has been extensively studied, it has not been previously implicated in mast cell biology. We observed that α2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and interleukin-6 responses during Listeria monocytogenes– and zymosan-induced peritonitis. Since exudative neutrophils of wild-type mice expressed little α2β1 integrin, it seemed unlikely that this integrin mediated neutrophil migration directly. Here, we demonstrate constitutive α2β1 integrin expression on peritoneal mast cells. Although α2-null mice contain normal numbers of peritoneal mast cells, these α2-null cells do not support in vivo mast cell–dependent inflammatory responses. We conclude that α2β1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection.

Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences