jimnoneill/paper-to-field-training huggingface dataset:
Drug-use evaluation programs for psychotropic medications

Drug-use evaluation (DUE) programs for psychotropic medications at a state-operated mental health center are described. DUE programs were developed at Western Missouri Mental Health Center to monitor prescribing of medications in the hospital and ambulatory-care settings. DUE criteria were developed for all major groups of psychotropic medications: antipsychotics, antidepressants, antianxiety and hypnotic agents, lithium, and antiparkinsonian drugs. The criteria appear on special forms developed for the programs; pharmacists use these forms to evaluate every medication order for inpatients and every 50th medication order for ambulatory-care patients. Physicians are alerted to noncompliant prescribing practices by memorandum, oral consultation, or both. In 3204 inpatient DUEs conducted from July 1986 to December 1988, orders for antiparkinsonian drugs showed the poorest compliance with DUE criteria. In both the hospital and ambulatory-care settings, antiparkinsonian agents required the most follow-up. The overall compliance rate for inpatient DUEs was 84%; for ambulatory-care DUEs, the compliance rate was 64%. As a result of the ambulatory-care DUE program, basic laboratory studies and dyskinesia rating scales are being ordered on a more timely basis. These DUE programs have increased pharmacist monitoring of patient care and improved documentation of medication use.

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
An audio-video summarization scheme based on audio and video analysis

The availability of video files in the Internet is growing at an exceptional speed and in the near future video browsing will be a common activity. To facilitate such activity it will be necessary to have a small clip for any given video. Currently, video skimming and video summarization techniques can reduce the temporal representation of a given video. However, most of these techniques do not include audio in the produced summaries. Here, we propose a mechanism that, using audio and video analysis, produces video summaries coupled with intelligible audio. Experimental results show that the summaries are largely reduced (up to 50%) and that the perceived video quality may be comparable to the one of the original video (in term of jerkiness). Consumers satisfaction has been investigated through MOS and results show that our summaries can be considered as an alternative to the original videos.

Topic: Video Analysis and Summarization
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Degussa Stabilizers: Accessing the Chinese Market

Degussa, one of the top 10 chemical companies and the largest specialty chemical company in the world, started its operations in China in January 2003. According to one of the key tenets of the Degussa 2008 Program — Make China Happen — the company will significantly need to increase its sales in China by 2008, with focus on Degussa Stabilizers (a division of Degussa which began its operations in China in 2004). In 2005, Degussa Stabilizers held a market share of about 10 percent (in terms of value). Despite positive results, it could not meet the required growth rate and market share projected by the company. Therefore, in order to strengthen its position in the market, the management team of Degussa Stabilizers decided to minimize the production cost and improve customer services. This case challenges students to analyze and evaluate the company's position. Based on the findings from the case study, the students are required to make recommendations that will help Degussa China to adapt to the rapid market changes and increased competition.

Topic: Higher Education Governance and Development
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Introduction of software engineering to freshman: Challenges and rewards

It is likely that the first programming course that a Software Engineering (SE) or a Computer Science (CS) freshman student takes at a university is Object- Oriented (OO) Programming with Java. The emphasis in the typical course is on development/language basics. The importance of process, design, testing, etc., considered core elements of Software Engineering, are typically ignored in such a class. It is believed that these concepts can be taught in later courses. This paper describes our experience of incorporating the core elements of the software engineering process in the first programming course for freshman at the Milwaukee School of Engineering (MSOE). The evolution of the introductory programming sequence at MSOE along with our initial assessment is also presented.

Topic: Teaching and Learning Programming
Subfield: Computer Science Applications
Field: Computer Science
Domain: Physical Sciences
Analysis of the transport users’ behaviours and preferences commuting to traffic generators in Radom

Transport needs result from the essence of human needs (from the need for movement or from natural mobility) and from the scientific, cultural, economic or administrative activities carried out. They have a diverse character resulting from both objective and subjective reasons, and their consequence is the emergence of journeys. The specificity of these mobility can be analyzed in reference to various spaces related to the implementation of journeys.&#x0D; The purpose of the paper is to present the results of research carried out as part of the project Strategy for urban development of the Radom Functional Area (ROF). These studies concerned the recognition of transport users’ behaviours and preferences of commuting in Radom. The research was carried out in traffic generators performing the most important urban functions and defining the specificity of socio-economic processes in Radom.

Topic: transportation and logistics systems
Subfield: Transportation
Field: Social Sciences
Domain: Social Sciences
Abstract 3156: Construction and validation of an activating and inhibitory chimeric antigen receptor (CAR) system

Abstract Introduction: Chimeric antigen receptors (CARs) consists a promising type of adoptive immunotherapy. CARs consist of an antigen recognition unit (scFv), a transmembrane (TM) region and an intracellular activation domain. However, on target/off tumor responses due to target recognition in normal cells limits the widespread application of this therapy. In B-cell precursor acute lymphoblastic leukemia, lymphocytes expressing anti-CD19 CARs (19BBz) are being used in the clinical setting. However, the expression of CD19 as a pan-B marker can lead to undesired side effects such as depletion of mature B cells. As mature B cells express both CD19 and CD20 antigens, we propose the creation of an inhibitory anti-CD20 CAR, that when used in combination with 19BBz would be able to discriminate between leukemic blasts and normal B cells. Methods and results: Three inhibitory CARs were constructed containing signaling domains of CTLA-4, PD-1 or BTLA. Jurkat T cells expressing the plasmid pGL4.30 - expressing luciferase controlled by a NFAT responsive promoter - were generated. K562 cell line was used as target cells and modified to express CD19 (K5-19), CD20 (K5-20) or CD19 and CD20 (K5-19/20). In coculture experiments, Jurkat cells expressing 19BBz showed induction of luciferase activity when cultured with K5-19 or K5-19/20. However, Jurkat expressing both activation and inhibitory CAR showed inhibition of luciferase activity when incubated with K5-19/20 while maintained high activity when cultured with K5-19 cells. Furthermore, all three inhibitory CARs were able to inhibit the expression of the activation marker CD69 induced by 19BBz. In primary human T lymphocytes, the 20PD1 CAR did not inhibit proliferation or cytotoxicity induced by 19BBz. Surprisingly, T cells expressing 19BBz and 20PD1 showed preferential lysis of NALM6 CD19+ CD20+ cells, suggesting that the addition of PD1 domain may increase T-cell function in specific contexts. This effect was partially reversed by using a mutant PD1 domain where the tyrosines were replaced by phenylalanine and was completely reversed by using an anti-CD20 CAR truncated at the TM region, suggesting that this phenomenon is dependent of signaling. Conclusions: Additional experiments are needed to evaluate the activity of 20PD1 in primary human T cells. Experiments with inhibitory CARs 20LAG3 and 20PD1LAG3 are ongoing and can serve as an alternative to CAR 20PD1 in the construction of a conditional response system. Citation Format: Leonardo Chicaybam, Martin H. Bonamino. Construction and validation of an activating and inhibitory chimeric antigen receptor (CAR) system. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3156. doi:10.1158/1538-7445.AM2015-3156

Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Robust Optimization Design of Supply Chain Based on Correlated Multi-Performance Responses

Abstract Aiming at the problem of supply chain robust optimization with multiple performance responses, a robust optimization method was proposed by combining principal component analysis with double response surface method based on Kriging meta-model. Firstly, through principal component analysis, the location characteristics and divergence characteristics of multiple related performance responses were transformed into the principal component comprehensive score of supply chain performance; secondly, the Kriging metamodels of location characteristics and divergence characteristics of multiple performance responses were constructed respectively, and the principal component comprehensive score model of comprehensive performance based on Kriging meta-model was constructed. Thus the optimal operating conditions by optimizing the constructed robust optimization strategy were obtained in order to realize the robust optimization of supply chain system with correlated multiple responses. Finally, a supply chain simulation case was given to illustrate the effectiveness of our proposed optimization method, and the robustness of different methods was also discussed. The comparison results showed that our proposed was more robust.

Topic: Quality Function Deployment in Product Design
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Sources of imprecision in laboratories screening for congenital hypothyroidism: analysis of nine years of performance data.

Abstract We evaluated sources of imprecision in screening assays for congenital hypothyroidism performed between 1979 and 1987 by more than 45 laboratories participating in the national Neonatal Screening Standardization Program offered by the Centers for Disease Control. Reported concentrations were available from approximately 70,000 enriched dried-blood spot samples for thyroxin and thyrotropin, the primary and secondary screening assays, respectively. The most important sources of variation in assayed concentrations are within-laboratory imprecision and the methods or kits used. The importance of each of these sources depends on the analyte and its concentration. In most cases, the greatest source of measurement variation is attributable to within-laboratory imprecision (coefficient of variation 13% to 26%); however, kits are the largest source of variation at the lower concentrations of thyroxin. For both analytes, the greatest relative imprecision occurred at the low concentration, which was within the critical range of the cutoff values for detection of presumptive positive specimens. Imprecision in this range increases the risk of misclassifications. Minimizing within-laboratory imprecision and differences among kits seems to be the best way to improve overall efficiency of screening laboratories.

Topic: Metabolism and Genetic Disorders
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Search for Shangri-La: A Journey Into Tibetan History

The idea of a hidden refuge, a paradise far from the stresses of modern life, has universal appeal. In 1932 the writer James Hilton coined the word 'Shangri-La' to describe such a place, when he gave that name to a hidden valley in the Himalayas in his novel LOST HORIZON. In THE SEARCH FOR SHANGRI-LA acclaimed traveller and writer Charles Allen explores the myth behind the story. He tracks down the sources that Hilton drew upon in writing his popular romance, and then sets out to discover what lies behind the legend that inspired him. In the course of a lively and amusing account of his four journeys into Tibet, Allen also gives us a controversial new reading of the country's early history, shattering our notions of Tibet as a Buddhist paradise and restoring the mysterious pre-Buddhist religion of Bon to its rightful place in Tibetan culture. He also locates the lost kingdom of Shang-shung and, in doing so, the original Shangri-La itself: in an astounding gorge beyond the Himalayas, full of extraordinary ruins.

Topic: Indian and Buddhist Studies
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Hart and Punishment for Negligence

In Punishment and Responsibility, in the essay 'Negligence, Mens Rea and Criminal Responsibility', H. L. A. Hart defends criminalizing and punishing some acts of negligently causing or risking harm. Here is how he opens this essay: 'I didn't mean to do it: I just didn't think.' 'But you should have thought.' Such an exchange, perhaps over the fragments of a broken vase destroyed by some careless action, is not uncommon; and most people would think that, in ordinary circumstances, such a rejection of 'I didn't think' as an excuse is quite justified. No doubt many of us have our moments of skepticism about both the justice and the efficacy of the whole business of blaming and punishment; but, if we are going in for the business at all, it does not appear unduly harsh, or a sign of archaic or unenlightened conceptions of responsibility, to include gross, unthinking carelessness among the things for which we blame and punish. This does not seem like the 'strict liability' which has acquired such odium among Anglo-American lawyers. There seems a world of difference between punishing people for the harm they unintentionally but carelessly cause, and punishing them for the harm which no exercise of reasonable care on their part could have avoided.1

Topic: Free Will and Agency
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Green‐Light‐Induced Inactivation of Receptor Signaling Using Cobalamin‐Binding Domains

Abstract Optogenetics and photopharmacology provide spatiotemporally precise control over protein interactions and protein function in cells and animals. Optogenetic methods that are sensitive to green light and can be used to break protein complexes are not broadly available but would enable multichromatic experiments with previously inaccessible biological targets. Herein, we repurposed cobalamin (vitamin B12) binding domains of bacterial CarH transcription factors for green‐light‐induced receptor dissociation. In cultured cells, we observed oligomerization‐induced cell signaling for the fibroblast growth factor receptor 1 fused to cobalamin‐binding domains in the dark that was rapidly eliminated upon illumination. In zebrafish embryos expressing fusion receptors, green light endowed control over aberrant fibroblast growth factor signaling during development. Green‐light‐induced domain dissociation and light‐inactivated receptors will critically expand the optogenetic toolbox for control of biological processes.

Topic: Light effects on plants
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Neuromyotonia, myokymia and spinocerebellar ataxia in two Patterdale terrier littermates

Abstract Two Patterdale terrier siblings presented with a progressive history of a spinocerebellar ataxia present from 15 weeks of age. Both dogs had daily episodes of myokymia affecting all four limbs. The female dog had a history of three neuromyotonic attacks and was euthanased due to extreme hyperthermia during one attack. Both were homozygous for the genetic mutation of the KCNJ10 gene, which was previously reported in the Jack Russell terrier. This case highlights the clinical reasoning of abnormal gaits and abnormal episodes. This is the first report of this mutation in the Patterdale terrier.

Topic: Genetics and Neurodevelopmental Disorders
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Energetics and kinetics of the reaction of HOCO with hydrogen atoms

The potential energy surface for the reaction of HOCO radicals with hydrogen atoms has been explored using the CCSD(T)/aug-cc-pVQZ ab initio method. Results show that the reaction occurs via a formic acid (HOC(O)H) intermediate, and produces two types of products: H2O+CO and H2+CO2. Reaction enthalpies (0K) are obtained as −102.0kcal∕mol for the H2+CO2 products, and −92.7kcal∕mol for H2O+CO. Along the reaction pathways, there exists a nearly late transition state for each product channel. However, the transition states locate noticeably below the reactant asymptote. Direct ab initio dynamics calculations are also carried out for studying the kinetics of the H+HOCO reaction. At room temperature, the rate coefficient is predicted to be 1.07×10−10cm3molec−1s−1 with a negligible activation energy Ea=0.06kcal∕mol, and the branching ratios are estimated to be 0.87 for H2+CO2, and 0.13 for H2O+CO. In contrast, the product branching ratios have a strong T dependence. The branching ratio for H2O+CO could increase to 0.72 at T=1000K.

Topic: Atmospheric Ozone and Climate
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Methanol oxidation on stoichiometric and oxygen-rich RuO<sub>2</sub>(110)

We used temperature-programmed reaction spectroscopy (TPRS) to investigate the adsorption and oxidation of methanol on stoichiometric and O-rich RuO<sub>2</sub>(110) surfaces.

Topic: Catalytic Processes in Materials Science
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Fluorescein Microangiography of the Ocular Fundus

In a beautiful volume, appropriately titled Fluorescein Microangiography of the Ocular Fundus , Dr. Shimizu offers a sequel to his first text on the subject, Atlas of Fluoresence Fundus Angiography , published five years earlier with Dr. S. Shikano. The author intends the present book to supplement the first. In this work one is treated to a visual feast of fundus angiograms, which are stunning in their contrast and resolution. Photographically, it stands in its area as a landmark of clinical and publishing excellence. Unless the full potential of the technically refined method of fluorescein angiography for demonstrating fine vessel structure and dynamics had been realized, the basic attempt of the book, as connoted by the title, would have been futile. In an admirable way, Dr. Shimizu demonstrates the many kinds of information that can be extracted from high quality fluorograms. Throughout, he attempts to formulate reasonable explanations for phenomena seen in

Topic: Retinal Diseases and Treatments
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Terpenoid Induction in Sweet Potato Roots by Cyclic-3′, 5′-Adenosine Monophosphate

Journal Article Terpenoid Induction in Sweet Potato Roots by Cyclic-3′, 5′-Adenosine Monophosphate Get access Itaro Oguni, Itaro Oguni Laboratory of Food Chemistry, Shizuoka Women’s College, Nunohashi, Hamamatsu 432 Search for other works by this author on: Oxford Academic Google Scholar Keiko Suzuki, Keiko Suzuki Laboratory of Food Chemistry, Shizuoka Women’s College, Nunohashi, Hamamatsu 432 Search for other works by this author on: Oxford Academic Google Scholar Ikuzo Uritani Ikuzo Uritani Laboratory of Biochemistry, Faculty of Agriculture, Nagoya University, Aichi 464, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 40, Issue 6, 1 June 1976, Pages 1251–1252, https://doi.org/10.1080/00021369.1976.10862203 Published: 01 June 1976 Article history Received: 19 January 1976 Published: 01 June 1976

Topic: Banana Cultivation and Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Impact of combining cross-docking and vendor managed inventory in a retail supply chain

The objective of this paper is to examine the impact of combining the cross-docking strategy (XD) and vendor managed inventory (VMI) in a retail supply chain. Particularly, the impact of combining XD and VMI, compared to VMI is investigated. The presented work is based on a case study research methodology. The research was done in collaboration with a fast moving consumer goods company and a French grocery retailer. A cost model has been developed to compare three different scenarios: 1) VMI scenario; 2) a XD scenario; 3) a combination of XD and VMI. The case study provides two main observations: 1) compared to VMI, XD is more economical: a 13% reduction of the cost; 3) combining XD and VMI reduces the supply chain cost by 28%. This paper fills a gap by proposing a cost analysis based on a real case study and by analysing the advantages of implementing different scenarios in the retail supply chain context. Furthermore, the cost model may be used to help managers choose the right distribution strategy for their supply chain.

Topic: Quality and Supply Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
[Effects of paradoxical sleep deprivation on the activity of opiate receptors isolated from synaptic membranes of the rat brain].

The specific binding of 3H-naloxone with opiate receptors isolated from brain synaptic membranes of control and paradoxical sleep deprived rats were studied. This extreme state was shown to reduce the naloxone-binding activity of synaptic membranes by 35% and isolated receptors by 25-28%. The values of Kd and Bmax were calculated for isolated opiate receptors at different stages of purification. Considerable decrease of 3H-naloxone binding sites density (2 times) in the isolated opiate receptors with simultaneous increase of their affinity (3-4,5 times) was found following 24 hours paradoxical sleep deprivation. These findings suggest development of fixed alterations in the structure and functions of integral receptor proteins under extreme influences.

Topic: Neuroscience and Neuropharmacology Research
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences