jimnoneill/paper-to-field-training huggingface dataset:
Establishment of the first international large-scale, genomic screening platform to identify patients with rare oncogene drivers in non-small cell lung cancer (NSCLC) in East Asia.

9605 Background: A rapidly increasing number of oncogenic drivers have been identified in non-small cell lung cancer (NSCLC), and most of them occur in less than 5% of patients. Large-scale genomic screening to identify patients with rare driver alterations is thus necessary to enable precision medicine and to support the development of novel targeted therapies and companion diagnostics (CDx). Methods: A lung cancer genomic screening project (LC-SCRUM-Asia) capturing clinical outcome was established in 2013 with 206 institutions in Japan and 5 in Taiwan currently participating. A separate genomic screening project with similar structure was established in China (LC-IRICA-China) in collaboration with LC-SCRUM-Asia in 2019 (3 institutions enrolling, 17 about to open, 63 undergoing review). Samples are analyzed by a multi-gene PCR panel and targeted next-generation sequencing. The target is to enroll 70000 NSCLC patients (20000 from LC-SCRUM-Asia and 50000 from LC-IRICA-China) by 2022. Results: From March 2013, a total of 9383 lung cancer patients were enrolled in LC-SCRUM-Asia, and from October 2019, 1649 pts were included in LC-IRICA-China (January 2020). The rates of genomic alterations in LC-SCRUM-Asia: EGFR (17%) of which ex20ins (2%), KRAS (13%) of which G12C (4%), ALK fusions (2%), ROS1 fusions (2%), RET fusions (2%), HER 2 ex20ins (3%), MET ex14skip (2%), BRAF V600E (1%), NRG1 fusions (0.2%) and NTRK3 fusions (0.03%). Corresponding rates in the initial 243 pts in LC-IRICA China: EGFR (45%) of which ex20ins (2%), KRAS (8%), ALK (5%), ROS1 (2%), RET (1%), HER2 (2%), MET ex14skip (1%), BRAFV600E (1%). Through the screening, 266 patients from Japan and Taiwan were enrolled into genotype-matched clinical trials of unapproved targeted drugs. In Japan, ROS1-, BRAF- and TRK-targeted therapies were successfully approved based on these clinical trials, and a NGS-based multi-gene CDx for EGFR/ALK/ROS1/BRAF targeted-therapies was approved based a concordance study using archival samples from the project. Conclusions: An East Asian international genomic screening platform has been established to enable precision medicine for patients, accelerate drug and diagnostic development in patients with very rare alterations and to help provide a deeper understanding of the underlying biology of NSCLC in East Asian patients. The screening network will be further expanded to other countries in East Asia in the near future.

Topic: Cancer Genomics and Diagnostics
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The influence of developer multi-homing on competition between software ecosystems

Having a large number of applications in the marketplace is considered a critical success factor for software ecosystems. The number of applications has been claimed to determine which ecosystems holds the greatest competitive advantage and will eventually dominate the market. This paper investigates the influence of developer multi-homing (i.e., participating in more than one ecosystem) in three leading mobile application ecosystems. Our results show that when regarded as a whole, mobile application ecosystems are single-homing markets. The results further show that 3% of all developers generate more than 80% of installed applications and that multi-homing is common among these developers. Finally, we demonstrate that the most installed content actually comprises only a small number of the potential value propositions. The results thus imply that attracting and maintaining developers of superstar applications is more critical for the survival of a mobile application ecosystem than the overall number of developers and applications. Hence, the mobile ecosystem is unlikely to become a monopoly. Since exclusive contracts between application developers and mobile application ecosystems are rare, multi-homing is a viable component of risk management and a publishing strategy. The study advances the theoretical understanding of the influence of multi-homing on competition in software ecosystems.

Topic: Digital Platforms and Economics
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
BS 1149.1 extensions for an online interconnect fault detection and recovery

Loss of signal integrity in today's deep sub-micron designs puts communication links at a higher risk of permanent or more frequent intermittent faults. This results in performance and reliability reduction. This paper presents an online interconnect BIST method that applies to a hybrid serial/parallel communication scheme. The proposed BIST method is implemented by a simple extension to the boundary scan standard, which facilitates online testing methodology with negligible hardware overhead. The online hardware works in the idle state of the Boundary Scan TAP controller. The proposed method includes fault detection and diagnosis phases. Moreover, for error handling, it uses the same test hardware added to the communication interface. It effectively reuses the existing boundary scan structure to act as a signature generator, an error detector and locater for testing interconnects, and an error handling mechanism. Our method can detect about 90% of the interconnect faults after six block transfers.

Topic: VLSI and Analog Circuit Testing
Subfield: Hardware and Architecture
Field: Computer Science
Domain: Physical Sciences
A Study Of Sir/Epdm Mixtures For Outdoor Insulators

This paper deals with the flashover voltages on samples of silicone rubber/ethylene propylene diene monomer (SiR/EPDM) mixtures under the influence of a uniform electric field. Five different mixtures of SiR/EPDM were investigated. Various SiR/EPDM mixtures (100% EPDM, 10% SiR + 90% EPDM, 30% SiR + 70% EPDM, 50% SiR + 50% EPDM, 70% SiR + 30% EPDM, 90% SiR + 10% EPDM, 100% SiR) were tested for different water droplet arrangements, different water conductivities, different droplet volumes as well as different droplet positioning w.r.t. the electrodes. The 50% SiR + 50% EPDM mixture proved to be the best mixture regarding the flashover voltage.

Topic: High voltage insulation and dielectric phenomena
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Effect of early stage hyperglycemia on prognosis in patients with acute craniocerebral injury

【Objective】To investigate the effect of hyperglycemia on prognosis in patients with acute craniocerebral injury.【Methods】The level of blood glucose was monitored in 57 cases of craniocerebral injury who had no history of diabetes or important extracranial complications.The relationship between the level of blood glucose and the degrees of injury as well as the prognosis was analyzed.【Results】Patients with mild(GCS 13～15),moderate(GCS 9～12) or severe(GCS 3～8) traumatic brain injury showed hyperglycemia at different level,and the level of blood glucose was consistent with the degree of injury.The average blood glucose level of patients with moderate traumatic brain injury was significantly higher than that of patients with mild traumatic brain injury(P 0.05).The average blood glucose level of patients with severe traumatic brain injury was significantly higher than that of patients with mild or moderate traumatic brain injury(P 0.05).The death rate of patients with blood glucose11.1 mmol/L was significantly higher than that of patients with blood glucose11.1 mmol/L(P 0.05).The blood glucose level of non-survivors was significantly higher than that of survivors(P 0.05).【Conclusion】Hyperglycemia reflects the severity of traumatic brain injury,which can be used as an early and simple indicator of prognosis.

Topic: Hyperglycemia and glycemic control in critically ill and hospitalized patients
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Efficacy of Topical Alpha Ointment (Containing Natural Henna) Compared to Topical Hydrocortisone (1%) in the Healing of Radiation-Induced Dermatitis in Patients with Breast Cancer: A Randomized Controlled Clinical Trial

Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients. &#13;\nMethods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy]) and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30) or topical hydrocortisone cream (1%) (control arm, n=30) immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. &#13;\nResults: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) (P=0.001). This effect was significant in the second week (P=0.007). In addition, Alpha ointment decreased the patients’ complaints such as pain (P&lt;0.001), pruritus (P=0.009), and discharge (P=0.010) effectively and meaningfully. &#13;\nConclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) in our patients with breast cancer. &#13;\nTrial Registration Numbers: IRCT201206099979N1&#13;\n ACTRN12612000837820

Topic: Complementary and Alternative Medicine Studies
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
A Risk-Based Cost Contingency Estimation Model for Infrastructure Projects

Cost overrun of infrastructure projects is widespread and represents significant financial risks to stakeholders. The cluster analysis on the data of 41 commonly cited causes identified four dimensions of causes: scope changes, market and regulatory uncertainty, inadequate planning and control, and unforeseen circumstances. Subsequently, these four dimensions were then used to develop a risk-based cost contingency estimation model (RBCCEM) to improve the accuracy of cost contingency estimation which was then validated using a bootstrapping approach. The accuracy of the cost estimation measures was used to compare RBCCEM with other methods, namely fixed cost contingency, reference class forecasting, and a hybrid method. The findings suggested that RBCCEM could be more accurate as the error decreased by 10%. As a result, RBCCEM produces contingency estimates that are more consistent and brings project costs closer to actual costs than alternative approaches, such as reference class forecasting (RCF).

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
LHD Crystal3 #186884.1

X-ray crystal spectrometer is mesurement for ion temperature in the plasma center of a large helical device (LHD) using Doppler broadening of a He-like resonance line of ArXVII, TiXXI, CrXXIII, or FeXXV.

Topic: Hearing Loss and Rehabilitation
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Notification of Publisher Error

The publisher regrets that a production error occurred which led to the publication of a retraction notice that was linked to this article. The retraction notice was not associated with this article and has been removed from the publication record of the article.This error bears no reflection on the article or its authors. The publisher apologizes to the authors and the readers for this unfortunate error.

Topic: Radiology practices and education
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
A De-Embedding Method to Characterize Differential

This paper analyses the noise and gain measurement of microwave differential amplifiers using two passive baluns. A model of the baluns that includes potential losses and unbalances has been considered. This analysis allows to de-embed the actual performance of the differential device from the single-ended measurements of the two-port cascaded system and the baluns. The method has been validated with measured results from a fully-differential amplifier prototype.

Topic: Radio Frequency Integrated Circuit Design
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Strategies for Reducing Secondary or Vicarious Trauma: Do They Work?

This cross-sectional design study sought to assess whether therapists believed and engaged in commonly recommended forms of prevention for secondary and vicarious trauma and whether engaging in these activities resulted in lower levels of distress. In this study of 259 therapists, time spent with counseling trauma victims was the best predictor of trauma scores. Although participants generally believed in the usefulness of recommended&#13;\ncoping strategies including leisure activities, self-care activities and supervision, these beliefs did not translate into time devoted to engaging in the activities. Most importantly, there was no association between time devoted to coping strategies and traumatic stress scores. Intervention strategies for trauma counselors that focus on education of therapists and augmenting coping skills unduly individualize the problem.

Topic: Migration, Health and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Zirconia-Based Aerogels for Sorption and Degradation of Dimethyl Methylphosphonate

Inspired by recent breakthroughs with Zr(OH)4-type materials that decompose chemical warfare agents (CWAs), we explore aerogel forms of zirconium oxyhydroxide (ZrOxHy) as reactive sorbents for dimethyl methylphosphonate (DMMP), a common simulant for organophosphorous CWAs. Zirconia gels were synthesized using propylene oxide and aqueous ZrCl4, followed by supercritical-CO2 extraction to yield monolithic ZrOxHy aerogels. Subsequent calcination at temperatures ≥350 °C removes organic byproducts of the epoxide-based synthesis while preserving high specific surface area (up to 234 m2 g–1) and the aerogel-like, cocontinuous pore-solid structure. Infrared (IR) spectroscopy and 1H nuclear magnetic resonance spectroscopy confirm that ZrOxHy aerogels retain a high concentration of surface hydroxyls, even when heated to 600 °C and converted to nanocrystalline cubic/monoclinic ZrO2. We used in situ IR spectroscopy to probe the interactions of DMMP with a series of ZrOxHy aerogel powders, showing that DMMP rapidly decomposes by reacting with the hydroxyl-rich aerogel to form surface-bound Zr–OCH3 and bridging O–P–O species. We compare these results to those of related zirconia-type materials and discuss prospects and advantages of ZrOxHy aerogels for CWA mitigation.

Topic: Pesticide Exposure and Toxicity
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Constructing an adult orofacial premotor atlas in Allen mouse CCF

Premotor circuits in the brainstem project to pools of orofacial motoneurons to execute essential motor action such as licking, chewing, breathing, and in rodent, whisking. Previous transsynaptic tracing studies only mapped orofacial premotor circuits in neonatal mice, but the adult circuits remain unknown as a consequence of technical difficulties. Here, we developed a three-step monosynaptic transsynaptic tracing strategy to identify premotor neurons controlling vibrissa, tongue protrusion, and jaw-closing muscles in the adult mouse. We registered these different groups of premotor neurons onto the Allen mouse brain common coordinate framework (CCF) and consequently generated a combined 3D orofacial premotor atlas, revealing unique spatial organizations of distinct premotor circuits. We further uncovered premotor neurons that simultaneously innervate multiple motor nuclei and, consequently, are likely to coordinate different muscles involved in the same orofacial motor actions. Our method for tracing adult premotor circuits and registering to Allen CCF is generally applicable and should facilitate the investigations of motor controls of diverse behaviors.

Topic: Neural dynamics and brain function
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Total proteins and 11S protein fraction (Helianthinin) of sunflower seed (<i>Helianthus annuus</i> L.) — Effect of acetylation and succinylation

Abstract The total proteins and helianthinin (11S) from sunflower seeds were chemically modified by acetylation and succinylation. The extent of acetylation of the total proteins and helianthinin were 12%, 51%, 52%, 56% and 12%, 36%, 69%, 71%, respectively, while the extent of succinylation were 8%, 21%, 33%, 49% and 10%, 30%, 44%, 61%, respectively. The extent of modification was monitored by the availability of free lysyl residues in the proteins. The ultraviolet absorption maximum shifted to higher wavelengths in total proteins and in helianthinin; there was also an increase in absorbance in the 260 nm wavelength, as a function of increased chemical modification. The sedimentation velocity profile indicated the dissociation of the proteins to low molecular weight fraction (2S) through a 7S component. The dissociation occurred at low modification levels in both total proteins and in helianthinin. There was a gradual red shift and quenching in the fluorescence emission maximum at higher modification levels indicating the denaturation of the proteins as a result of this chemical modification. The change in absorbance as a function of temperature indicates minor changes suggesting that the conformation of the proteins is already altered to significant extents due to the chemical modification.

Topic: Phytase and its Applications
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Comparative habitat use by syntopic Kelp Gulls (<i>Larus dominicanus</i>) and Olrog's Gulls (<i>L. atlanticus</i>) in coastal Patagonia

We studied comparative microhabitat use by breeding Kelp Gull (Larus dominicanus) and the threatened Olrog's Gull (Larus atlanticus) at six colonies through the distributional range of Olrog's Gull in coastal Patagonia, Argentina. The ranges of values for most of the 13 microhabitat variables measured (related to vegetation, soil and topography) were broader for the Kelp Gull than Olrog's Gull, with those of that latter within the range of Kelp Gull, indicating potential spatial conflict between the two species. There was particular overlap in nest-site characteristics, but differences were observed between the two species. Multivariate analyses showed that the most important differences in habitat between the two species related to vegetation cover and distance to the high-tide line. Compared with Kelp Gulls, Olrog's Gulls placed their nests in sites with lower proportion of vegetation cover, lower percentages of silt-clay in the substrate, and closer to the high-tide line. For both species the patterns of nest-site selection did not vary among colonies, although the extent of differences between the two species varied with availability of habitat at each colony. Although Olrog's Gulls started laying 12–14 days earlier than the larger Kelp Gulls, the latter occupied breeding colonies earlier and may, therefore, interfere with settlement of Olrog's Gulls. Considering the increase in the numbers, colony area and nesting density of Kelp Gulls currently observed in coastal Patagonia, there is an urgent need to implement monitoring programs for both species and conduct studies to better predict the results of their interactions.

Topic: Avian ecology and behavior
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Helping Plants Survive Heat Stress

Plants rely on microorganisms in the local environment for various important processes. One of the most commonly known is nitrogen fixation by symbiotic bacteria that colonize the roots of some plants. McLellan et al . provide evidence that fungi in the rhizosphere (the soil surrounding the roots of plants) may also contribute to heat tolerance. Previously, two inhibitors of mammalian heat shock protein 90 (HSP90) were discovered in extracts from Sonoran desert plant-associated fungi, McLellan et al . follow up on this result and show that one of these, monocillin I (MON), specifically binds and inhibits the chaperone activity of Arabidopsis HSP90 in vitro. Exposure of Arabidopsis seedlings to MON increased the expression and abundance of the heat shock response protein AtHSP101. Pretreatment of seedlings with MON before what would be a lethal heat stress in untreated plants increased the survival of the MON-exposed seedlings. The rescue of growth by MON required HSP101, consistent with MON’s triggering the heat shock response. When Arabidopsis seedlings were cultured with the fungus that produces MON, hypocotyl elongation was decreased compared with that in plants grown in the absence of MON; however, the plants tolerated heat stress much better in the presence of the fungus. C. A. McLellan, T. J. Turbyville, E. M. K. Wijeratne, A. Kerschen, E. Vierling, C. Queitsch, L. Whitesell, A. A. L. Gunatilaka, A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor. Plant Physiol. 145 , 174-182 (2007). [Abstract] [Full Text]

Topic: Heat shock proteins research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Advanced bio-polymers for bone regeneration: Harnessing anti-inflammatory, oxidative stress, and pro-angiogenic strategies

Bone defects resulting from trauma, tumor resection, or infection constitute significant clinical challenges in orthopedics, frequently causing compromised healing and elevated complication rates. While inflammatory responses and reactive oxygen species (ROS) are essential for initiating bone repair, their excessive persistence disrupts osteoblast-osteoclast homeostasis, suppresses angiogenesis, and ultimately impedes osseous regeneration. Conventional treatments, including autografts, allografts, and synthetic materials (bioceramics/metals), exhibit limitations in biocompatibility, donor availability, and dynamic responsiveness to pathophysiological demands. Innovative polymer-based biomaterials integrating anti-inflammatory, ROS-neutralizing, and angiogenic functions enable precise spatiotemporal modulation of bone microenvironments through synergistic immunoregulation, vascular network formation, and osteogenic differentiation.This review examines the bone healing process and identifies bioactivators targeting key signaling pathways, including pharmaceuticals, metal ions, growth factors, and exosomes. We highlight advancements in multifunctional polymeric scaffolds, such as stimuli-responsive hydrogels, 3D-printed structures, and nanocomposite networks, which mimic the mechanical properties of the native extracellular matrix (ECM) and enable controlled delivery of bioactivators. Furthermore, we discuss recent progress and challenges in clinical translation, including large-scale production, sterilization techniques, and regulatory barriers. This review aims to provide researchers and clinicians with comprehensive insights to advance the development of next-generation polymers for bone regeneration.

Topic: Bone Tissue Engineering Materials
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences