jimnoneill/paper-to-field-training huggingface dataset:
Down‐regulation of interferon tau gene transcription with a transcription factor, EOMES

Abstract Interferon tau (IFNT), produced for a short interval during early pregnancy by the ruminant embryonic trophectoderm, is essential for the maintenance of early pregnancy, but the mechanism by which it is transcriptionally regulated has not been fully determined. To identify a transcription factor(s) involved in the down‐regulation of IFNT genes, mRNAs for various known transcription factors were investigated by reverse‐transcriptase and real‐time PCR in conceptus tissues collected on Days 15, 17, and 21, or Days 17, 20, and 22 of ovine or bovine pregnancy, respectively. In particular, the T‐box protein eomesodermin ( EOMES ) exhibited high mRNA expression in Day 17 or 22 ovine or bovine conceptuses. Interaction between EOMES and the identified transcription factors was studied using transient transfection, revealing that ovine/bovine IFNT ‐reporter transactivation was down‐regulated by EOMES. Transcription factor interactions with EOMES were further studied through immunoprecipitation, demonstrating an association between EOMES and cAMP‐response element binding protein (CREB)‐binding protein (CREBBP). Uterine flushing media collected from cyclic or early pregnancy animals were added to bovine trophoblast CT‐1 cells cultured on type‐I collagen (monoculture) or bovine uterine epithelial cells (coculture) in an attempt to regulate EOMES expression. In the coculture, but not the monoculture, addition of uterine flushing from Day 17 pregnant animals resulted in increased EOMES expression in CT‐1 cells. These results suggest that as conceptuses attach to the uterine epithelium, IFNT gene transcription is down‐regulated by an increase in EOMES expression and EOMES–CREBBP binding in the attached trophoblast cells. Mol. Reprod. Dev. 80: 371–383, 2013. © 2013 Wiley Periodicals, Inc .

Topic: Reproductive Physiology in Livestock
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Edukasi Penerapan Protokol Kesehatan COVID-19 Di SMAN Titian Teras Abdurrahman Sayoeti Kabupaten Muara Jambi

The spread of Coronavirus disease (COVID-19) is currently increasing, and it is very easy for transmission to occur, especially in an environment that is a center for gatherings. During this pandemic, schools are encouraged to do online learning, but there are some schools that are allowed to do face-to-face learning, one of which is SMA Titian Teras. This becomes very risky for an increase in the transmission of the Covid-19 virus in schools. Efforts that can be made to overcome this are education about the application of the COVID-19 health protocol. This education aims to increase knowledge and practice for teachers, educators, and students at Titian Teras High School in preventing the spread of the Covid-19 disease. This service is carried out at Titian Teras High School with a target number of 20 teachers/students/educational staff offline. This service activity was carried out by 3 lecturers and 5 students.

Topic: COVID-19 Prevention and Impact
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Interference Effects of Fuselage-Stored Missiles on Inlet Duct Model of an Interceptor-Type Aircraft at Mach Numbers 1.5 to 1.9

Memorandum presenting the effect of missile armament on the performance of an interceptor-type aircraft model at Mach numbers 1.5, 1.7, and 1.9 and at angles of attack up to 19 degrees. The aircraft model was characterized by triangular-shaped normal-shock inlets located at wing roots. Results regarding force measurements, effect of armament on inlet-duct performance, fuselage boundary-layer survey, and total-pressure contours at inlet throat and diffuser exit are provided.

Topic: Computational Fluid Dynamics and Aerodynamics
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Priority Analysis of Core Compact City Indicators incorporating the Preventive Planning Factors Against Urban Disaster

도시인구와 에너지 기후 환경의 변화, 경제적 위기 등으로 인하여 도시계획과 정책은 새로운 변화를 필요로 하고 있다. 도시계획의 새로운 패러다임 변화 속에서 압축도시는 지속가능성을 실현할 수 있는 바람직한 대안으로 주목받고 있다. 하지만 서울과 같은 대도시에 적용하는 데에는 한 가지 아쉬운 점이 있다. 바로 방재적 계획요인이 고려되지 못한 점이다. 시의적으로 도시방재계획의 중요성이 점차 높아지면서 자연재해와 도시안전 등의 방재 특성을 평가할 수 있는 지표 역시 반영되어야만 할 것으로 사료된다. 따라서 본 연구에서는 방재적 측면의 계획요인들을 반영하여 압축도시 지표를 개발하고 그 중요성을 비교 평가하고자 하였다. 분석결과, 전체 30개 압축도시 지표 중 방재관련 핵심 5개 지표의 중요도는 다음과 같이 나타났다. 범죄예방환경설계(6위), 건설안전관리(12위), 전염병 예방 및 의료보건서비스(16), 교통안전관리(18), 화재 및 자연재해 예방(20)순으로 산정되었으며, 특히 범죄예방환경설계와 건설안전관리 지표는 각각 상위 20%와 40%내에 포함되었다. It is necessary to concern new city planning and related policy changes due to urban population, economic crisis and changes in the weather and the circumstance. So, Compact City emerges major issue being useful alternative to carry out possible sustainability within a new paradigm of the urban planning. However, it has one of difficulties to apply them in metropolitan cities like Seoul because it is not considering Preventive Planning Factors. As importance of urban preventive plan becomes more crucial, it has to be concerned reflecting evaluation indicators of preventive characters such as urban safety and natural disasters. Therefore, this research aimed to evaluate their priority comparatively using the Analytic Network Process (ANP) after it established compact city indicators reflecting the planning factors in terms of prevention. According to the result, there were 5 essential indicators in priority among total 30 compact city indicators following; Crime prevention through Environmental design (Sixth), Safety in Maintenance and Construction works (twelfth), Epidemic prevention and medical health services (sixteenth), Traffic safety management (eighteenth), Fire and natural disaster prevention (twentieth). Especially some of indicators such as Crime prevention through Environmental design and Safety in Maintenance and Construction works were included in each top 20 and 40 percent.

Topic: Korean Urban and Social Studies
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
Nihilism and the Formulation of a Philosophy of Art

Nihilism is often associated with feelings of despair, hopelessness and meaningless. It is certainly true that once the implications of this philosophy become apparent that these feelings are valid. However, this reaction is merely the first stage of dealing with nihilism and stopping here fails to examine the various types of nihilism that deal specifically with knowledge, ethics, metaphysics, truth, and art. Nihilism at its base is a philosophy that recognizes the history of human thought and what it means to be and to think. My focus is the way in which a completed nihilism is in fact an emancipatory act and the implications it has for art and the artist in the 21st century.

Topic: Phenomenology and Existential Philosophy
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
A multi-epitope vaccine candidate developed from unique immunogenic epitopes against <i>Cryptosporidium hominis</i> by utilizing an immunoinformatics-driven approach

An immunoinformatics-based strategy is being investigated to identify prospective multi-subunit vaccine candidates against <i>Cryptosporidium hominis</i> (<i>C. hominis</i>). We used a systematic technique based on protein structure to create a competent multi-subunit vaccine candidate against <i>C. hominis</i>, with the likelihood of antigenicity, allergenicity, and transmembrane helices as the screening criteria. Using the suitable linkers, the best-screened epitopes such as B-cell epitopes (BCL), Helper T-lymphocytes (HTL), and cytotoxic T-lymphocytes (CTL) were linked together to intensify and develop the presentation and processing of the antigenic molecules. The greatest 3 D model of the component protein was created with the help of modeling software called Raptorax. The validation of the modeled protein was accomplished via the use of PROCHECK. Furthermore, using the ClusPro web server, the projected modeled structure was docked with known receptor TLR-4 to determine their interactions. A molecular dynamics (MD) simulation was used to investigate the stability of the multi-subunit vaccine bound with TLR-4 based on the docking score. Aside from that, the codon optimization and <i>in silico</i> expression demonstrate the possibility of high expression and simple purification of the vaccine product resulting from codon optimization. The overall findings indicated that the multi-subunit vaccine might be a viable vaccination candidate against <i>C. hominis.</i>Communicated by Ramaswamy H. Sarma.

Topic: vaccines and immunoinformatics approaches
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Figure 7 raw data: Effect of variable exposure to PTHrP (1-36) on bone nodules and AP activity in high plating density cultures.

RC cell cultures were maintained in control medium for 21 days (C/C), maintained in control medium and changed to medium containing PTHrP (1-36) on day 11 (C/P), treated with 100 nM PTHrP (1-36) for 21 days (P/P), or exposed to 100 nM PTHrP (1-36) for 10 days and then transferred to control medium on day 11 (P/C). The number of bone nodules (A) and AP activity (B) were determined on day 21.

Topic: Bone health and treatments
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
COGNITIVE MODELING COGNITIVE MODELING COGNITIVE MODELING — DIAGRAMATIC REASONING Formalizing Artistic Techniques and Scientific Visualization for Painted Renditions of Complex Information Spaces

This paper describes a new method for visualiz-ing complex information spaces as painted images. Scientific visualization converts data into pictures that allow viewers to “see ” trends, relationships, and patterns. We introduce a formal definition of the correspondence between traditional visualiza-tion techniques and painterly styles from the Im-pressionist art movement. This correspondence al-lows us to apply perceptual guidelines from visu-alization to control the presentation of information in a computer-generated painting. The result is an image that is visually engaging, but that also allows viewers to rapidly and accurately explore and ana-lyze the underlying data values. We conclude by applying our technique to a collection of environ-mental and weather readings, to demonstrate its vi-ability in a practical, real-world visualization envi-ronment. 1

Topic: ECG Monitoring and Analysis
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
THE PERIODATE-SCHIFF REACTION: SPECIFICITY, KINETICS, AND REACTION PRODUCTS WITH PURE SUBSTRATES

A quantitative test-tube method has been used to study the periodate-Schiff reaction of a number of pure substances. The rate of reaction, the amount of color produced, and in some cases the amount of periodate consumed, have been measured. The dye produced by different carbohydrates has been analyzed by spectrophotometry and paper chromatography. Glycogen, starch and dextran reacted slowly and produced much less color than the corresponding amount of free monosaccharides. Oligosaccharides and heteropolysaccharides were either periodate-Schiff-negative or very weakly positive. Proteins and nucleic acids were negative. There was no simple relation between the intensity of the periodate-Schiff reaction and the amount of periodate consumed or the amount of aldehyde groups formed on the oxidation by periodate. The dyes formed with different carbohydrates had essentially the same absorption curve, but differed in their chromatographic mobility.

Topic: Analytical Chemistry and Chromatography
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Comparative distribution of <sup>3</sup>H‐GABA uptake and GAD immunoreactivity in goldfish retinal amacrine cells: A double‐label analysis

Abstract The comparative distribution of 3 H‐GABA uptake and glutamic acid decarboxylase immunoreactivity (GAD‐ER) in amacrine cells of goldfish retina was studied simultaneously by using a combined autoradiographic/immunocytochemical technique in order to determine the degree of colocalization of these two markers of GABAergic neurons; 3 H‐GABA was taken up most intensely by large pyriform Ab amacrine cells (3% of inner nuclear layer (INL) somata), and less intensely by smaller, polyform amacrine cells (12% of INL somata), cell bodies in the ganglion cell layer (one‐half as common as Ab cells), and cell bodies in the inner plexiform layer (very rare). GAD‐IR was observed in 25% of amacrine cells in the INL, the vast majority of which were polyform in shape, and cell bodies in the ganglion cell layer. Twice as many cells were labeled for GAD‐IR as for 3 H‐GABA uptake. Of the cells that took up 3 H‐GABA, colocalization of 3 H‐GABA uptake and GAD‐IR was observed in 90% of the polyform amacrine cells, 80% of the cells in the ganglion cell layer, and none of the pyriform Ab amacrine cells or cells in the inner plexiform layer. We suggest that the polyform cells compose the major population of GABAergic amacrine cells in the goldfish retina, rather than the pyriform Ab cells. GABAergic displaced amacrine cells or ganglion cells are also indicated by our data. The implications of these data with regard to the physiology of the goldfish retina are discussed as well.

Topic: Retinal Development and Disorders
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Orographic Drag Associated with Lee Waves Trapped at an Inversion

Abstract The drag produced by 2D orographic gravity waves trapped at a temperature inversion and waves propagating in the stably stratified layer existing above are explicitly calculated using linear theory, for a two-layer atmosphere with neutral static stability near the surface, mimicking a well-mixed boundary layer. For realistic values of the flow parameters, trapped-lee-wave drag, which is given by a closed analytical expression, is comparable to propagating-wave drag, especially in moderately to strongly nonhydrostatic conditions. In resonant flow, both drag components substantially exceed the single-layer hydrostatic drag estimate used in most parameterization schemes. Both drag components are optimally amplified for a relatively low-level inversion and Froude numbers Fr ≈ 1. While propagating-wave drag is maximized for approximately hydrostatic flow, trapped-lee-wave drag is maximized for l2a = O(1) (where l2 is the Scorer parameter in the stable layer and a is the mountain width). This roughly happens when the horizontal scale of trapped lee waves matches that of the mountain slope. The drag behavior as a function of Fr for l2H = 0.5 (where H is the inversion height) and different values of l2a shows good agreement with numerical simulations. Regions of parameter space with high trapped-lee-wave drag correlate reasonably well with those where lee-wave rotors were found to occur in previous nonlinear numerical simulations including frictional effects. This suggests that trapped-lee-wave drag, besides giving a relevant contribution to low-level drag exerted on the atmosphere, may also be useful to diagnose lee-rotor formation.

Topic: Ionosphere and magnetosphere dynamics
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Stability of a Natural-Based Cream Containing <i>Lecythis pisonis</i> Extract.

The outer pericarps of <i>Lecythis pisonis</i> Camb. are by-products with a high content of antioxidant substances. The goal of the present study was to analyze the incorporation of <i>L. pisonis</i> pericarp extract in an all-natural formulation. Physical-chemical and organoleptic characteristics and Challenge tests were evaluated before and after the stability test of the cosmetic formulation. The instability of the formulation increased with the increase of the concentration of the extract. The physical-chemical and organoleptic parameters did not present alterations after the stability test. The extract of the outer pericarp of <i>L. pisonis</i> seems to be compatible with the cream formulation. However, the concentration should be analyzed to not interfere with the stability of the product. The natural formulation developed is under the legal requirements of the National Agency of Sanitary Monitoring of Brazil (Agência Nacional de Vigilância Sanitária), presenting an efficient conservation system.

Topic: Phytochemistry Medicinal Plant Applications
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
ST-segment elevation myocardial infarction

Acute myocardial infarction with ST-segment elevation is a common and dramatic manifestation of coronary artery disease. It is caused by the rupture of an atherosclerotic plaque in a coronary artery, leading to its total thrombotic occlusion and resultant ischaemia and necrosis of downstream myocardium. The diagnosis of ST-segment elevation myocardial infarction is based on a syndrome of ischaemic chest pain symptoms, associated with typical ST-segment elevation on the electrocardiogram and an eventual rise in biomarkers of myocardial necrosis. The treatment of ST-segment elevation myocardial infarction is focused on re-establishing blood flow in the coronary artery involved, preferably by percutaneous coronary intervention, or by pharmacological thrombolysis in the case of expected lengthy time delays or lack of availability of facilities. Early mortality from ST-segment elevation myocardial infarction can be attributed to the sequelae or complications of myocardial ischaemia, or complications related to therapy. The former include arrhythmias (such as ventricular tachycardia or fibrillation), mechanical complications (such as ventricular free wall, septal, and mitral chordal rupture), and pump failure leading to cardiogenic shock. The latter includes haemorrhagic complications and coronary stent thrombosis. Given that myocardial necrosis is a critically time-dependent process, the organization of an ST-segment elevation myocardial infarction care system and adherence to the latest clinical trial evidence and guidelines are crucial to ensure that patients are treated in an optimal manner.

Topic: Acute Myocardial Infarction Research
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Correction: Being on the Field When the Game Is Still Under Way. The Financial Press and Stock Markets in Times of Crisis

This paper looks at the relationship between negative news and stock markets in times of global crisis, such as the 2008/ 2009 period.We analysed one year of front page banner headlines of three financial newspapers, the Wall Street Journal, Financial Times, and Il Sole24ore to examine the influence of bad news both on stock market volatility and dynamic correlation.Our results show that the press and markets influenced each other in generating market volatility and in particular, that the Wall Street Journal had a crucial effect both on the volatility and correlation between the US and foreign markets.We also found significant differences between newspapers in their interpretation of the crisis, with the Financial Times being significantly pessimistic even in phases of low market volatility.Our results confirm the reflexive nature of stock markets.When the situation is uncertain and unpredictable, market behaviour may even reflect qualitative, big picture, and subjective information such as streamers in a newspaper, whose economic and informative value is questionable.

Topic: Market Dynamics and Volatility
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Turgor and osmotic relations of the desert shrub <i>Larrea tridentata</i>

Abstract Leaf water relations characteristics of creosote bush, Larrea tridentata , were studied in view of previous reports that its leaves commonly experience zero or negative turgor under dry conditions. Leaf turgor loss point ( ) was determined by a pressure‐volume method for samples subjected to a hydration procedure and for untreated samples. Hydration caused to increase by as much as 3 M Pa. Hydration of samples also caused changes in other leaf water relations characteristics such as symplastic solute content, tissue elasticity and symplasmic water fraction, but total leaf solute content was unchanged. Comparison of our field plant water potential data with values of obtained by the two methods resulted in predictions of turgor loss during part or all of a diurnal cycle based on hydrated samples, and turgor maintenance (at least 0.3 MPa) based on untreated samples. Pooled data for obtained from both partially hydrated and untreated samples showed that L. tridentata maintains fairly constant levels of turgor over a wide range of leaf water potential. Dilution of cell contents by apoplastic water introduced significant errors in psychrometric determinations of osmotic potential in both frozen and thawed leaf tissue and expressed cell sap. Use of these values of osmotic potential resulted in predictions of zero turgor at all plant water potentials measured in the field.

Topic: Plant responses to water stress
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Supplementary Figure 1 from &lt;i&gt;MGMT&lt;/i&gt;-STP27 Methylation Status as Predictive Marker for Response to PCV in Anaplastic Oligodendrogliomas and Oligoastrocytomas. A Report from EORTC Study 26951

&lt;p&gt;Supplementary figure 1 - PDF file 810K, Comparison of baseline variables on Humanmethylation450 beadchips&lt;/p&gt;

Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Applying cooperative coevolution to compete in the 2009 TORCS Endurance World Championship

The TORCS Endurance World Championship is an international competition in which programmers develop and tune their drivers to race against each other using TORCS, a state-of-the-art car racing simulator. In this work, we applied evolutionary computation to develop a driver for the 2009 edition of this competition. In particular, we focused on the optimization of the car setup of an existing driver (the winner of the 2008 edition) and applied cooperative coevolution to evolve the best car setup for the qualifying rounds of each leg of the championship. After 10 legs involving 12 teams, our driver was able to reach the 4th position in the final standings. We believe that this is a very promising result especially if we consider that we only focused on the car setup and the other teams participated also to most of the previous four editions (gaining much domain knowledge). Overall, our results show that cooperative coevolution can be very effective in this complex optimization task producing setups that can be competitive with respect to the ones tuned by human experts. Therefore, our results also suggest that simple evolutionary computation might represent a helpful tool to human designers for improving the performance of already heavily tuned drivers.

Topic: Sports Analytics and Performance
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences