jimnoneill/paper-to-field-training huggingface dataset:
[Effects of acute lymphoblastic leukemia children bone marrow mesenchymal stem cells on drug resistance of K562/A02 cell line].

The aim of study was to investigate the effect of acute lymphoblastic leukemia (ALL) children bone marrow mesenchymal stem cells (MSC) on resistance of K562/A02 cells and its mechanism. MSC obtained from bone marrow of AL children were cultured and identified. The co-culture of MSC and K562/A02 and the culture of K562/A02 cell suspension alone was performed, of which 2 kinds of cells were treated with same concentration of adriamycin (ADM), and the rate of apoptosis was detected by flow cytometry, bcl-2 and bax of K562/A02 were detected by RT-PCR, while mdr1 gene level was detected by FQ-PCR. The results indicated that the MSC separation and proliferation were viable and steady. The apoptosis rate of the K562/A02 cells co-cultured with MSC was 1.97 ± 0.11%, while apoptosis rate of the K562/A02 cells cultured alone was 8.38 ± 0.29%, there was significant difference (p < 0.05). As compared with the K562/A02 cells cultured alone, the bcl-2 gene expression in K562/A02 cells co-cultured with MSC obviously increased; ratio of bcl-2/bax was obviously enhanced. The mdr1 gene level in K562/A02 co-cultured with MSC was no statistical different from K562/A02 cultured alone (p > 0.05), which suggested that adhesion co-cultured with MSC did not induce mdr1 expression higher than the culture of suspension. It is concluded that the MSC of ALL children can escape the leukemia cells from proapoptotic effect of drugs, the resistance of K562/A02 to ADM may be involved in enhancement of bcl-2 gene expression of K562/A02 cells co-cultured with MSC, but not in relation to mdr1 gene in K562/A02 cells themselves.

Topic: Mesenchymal stem cell research
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Synthesis, Structure, and Characterization of New Mononuclear Mn(II) Complexes. Electrochemical Conversion into New Oxo-Bridged Mn<sub>2</sub>(III,IV) Complexes. Role of Chloride Ions

Two Mn(II) complexes are isolated and X-ray characterized, namely, cis-[(L(2))Mn(II)(Cl)(2)] (1) and [(L(3))Mn(II)Cl(OH(2))](ClO(4)) (2(ClO(4))), where L(2) and L(3) are the well-known tetradentate N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine and N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)propane-1,3-diamine ligands, respectively. The crystal structure reveals that whereas the ligand L(2) is in the cis-alpha conformation in complex 1, the ligand L(3) is in the more unusual cis-beta conformation in 2. EPR spectra are recorded on frozen solutions for both complexes and are characteristic of Mn(II) species. Electrochemical behaviors are investigated on acetonitrile solution for both complexes and show that cation 2 exists as closely related Mn(II) species in equilibrium. For both complexes exhaustive bulk electrolyses of acetonitrile solution are performed at oxidative potential in various experimental conditions. In the presence of 2,6-lutidine and after elimination of chloride ligands, the formation of the di-mu-oxo mixed-valent complexes [(L(2))Mn(III)(mu-O)(2)Mn(IV)(L(2))](3+) (3a) and [(L(3))Mn(III)(mu-O)(2)Mn(IV)(L(3))](3+) (4) is confirmed by UV-vis and EPR spectroscopies and cyclic voltammetry. In addition crystals of 4(ClO(4))(3) were isolated, and the X-ray structure reveals the cis-alphaconformation of L(3). In the absence of 2,6-lutidine and without elimination of the exogenous chloride ions, the electrochemical oxidation of 1 leads to the formation of the mononuclear Mn(III) complex, namely, [(L(2))Mn(III)(Cl)(2)](+) (5), as confirmed by UV-vis as well as parallel mode EPR spectroscopy and cyclic voltammetry. In the same conditions, the electrochemical oxidation of complex 2 is more intricate, and a thorough analysis of EPR spectra establishes the formation of the binuclear mono-mu-oxo mixed-valent [(L(3))ClMn(III)(mu-O)Mn(IV)Cl(L(3))](3+) (6) complexes. Electrochemical conversion of Mn(II) complexes into mixed-valent Mn(2)(III,IV) oxo-bridged complexes in the presence of 2,6-lutidine is discussed. The role of the chloride ligands as well as that of L(3) in the building of oxo bridges is discussed. Differences in behavior between L(2) and L(3) are commented on.

Topic: Metal-Catalyzed Oxygenation Mechanisms
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Attraction and Development of Ips Bark Beetle Populations in Artificially Infested Pine Bolts Exposed on Firetowers and Turntables in Florida

The rapid buildup of Ips bark beetle populations in suitable host material has been investigated by several workers. Among these, Anderson (1948) first noted that Ips pini (Say) adults were not strongly attracted to uninfested host logs. After a few beetles had entered these logs, the logs then became attractive to other I. pini of both sexes. Anderson further observed that only males newly established in the inner bark attracted other males and females. Wood and Vite (1961) found a similar pattern of behavior in Ips confusus, (Le Conte). The studies presented here concern some of the characteristics of attraction and population development in Florida Ips species.

Topic: Forest Insect Ecology and Management
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Pilot Trial of a Smartphone-Based Intervention to Reduce Alcohol Consumption among Veterans with HIV

Veterans engage in disproportionate levels of alcohol use, which can impact treatment outcomes among veterans with HIV. The TRAC (Tracking and Reducing Alcohol Consumption) intervention, which combines smartphones, mobile breathalyzers, and motivational interviewing (MI), was developed to help reduce alcohol use among this population. This study reports results of an 8-week pilot trial of TRAC among veterans with HIV (<i>N</i> = 10). Participants attended weekly MI sessions conducted <i>via</i> videoconferencing or phone and completed twice-daily self-monitoring of alcohol consumption using breathalyzers and surveys. They also completed pre- and post-intervention questionnaires and a qualitative interview. Analyses explored adherence to self-monitoring tasks, perceptions of the intervention, and preliminary effects of TRAC on alcohol use and readiness to change drinking behavior. Participants completed 76% of breathalyzer readings and 73% of surveys and completed more daytime than evening monitoring tasks. AUDIT hazardous drinking scores significantly decreased between baseline and post-test. Qualitative interviews revealed positive attitudes toward the technologies and MI sessions. Overall, this pilot demonstrated that the TRAC intervention has potential to reduce alcohol use among veterans with HIV, though additional effort is needed to improve adherence to mobile monitoring. Results were used to refine the intervention in preparation for a randomized controlled trial.

Topic: HIV/AIDS Research and Interventions
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Crosslinguistic variation in the processing of aspect

Bott, O. &amp; F. Hamm (submitted). Crosslinguistic variation in the processing of aspect. In B. Hemforth, B. Schmiedtová &amp; C. Fabricius-Hansen (eds.), Psycholinguistic Approaches to Meaning and Understanding across Language. (Studies in theoretical psycholinguistics). Berlin et al.: Springer.

Topic: Discourse Analysis and Cultural Communication
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Effect of Short Fermentation Times with Lactobacillus paracasei in Rheological, Physical and Chemical Composition Parameters in Cassava Dough and Biscuits

Dough fermentation with lactic acid bacteria has been extensively studied due to the associated health benefits and its effects on physical and rheology parameters in dough and bread. However, most of the studies rely on long fermentation times. The aim of this study is to evaluate the effect of short fermentation times (0 to 8 h) with Lactobacillus paracasei in rheology, physical and chemical properties on cassava dough and biscuits. Both storage modulus and loss modulus decreased as the fermentation times increased, down to 54,206.67 ± 13,348 and 17,453.89 ± 3691 Pa, respectively. Fermentation with L. paracasei influenced biscuit’s hardness and chemical properties, and gas cell sizes were increased notably. These results suggest that short fermentation times could be used to improve dough’s rheological characteristics.

Topic: Food composition and properties
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Synthesis, α-Amylase Inhibitory Activity and Molecular Docking Studies of 2,4-Thiazolidinedione Derivatives

Introduction: 2,4-Thiazolidinedione and its derivatives exhibit a variety of pharmacological activities including antidiabetic, antiviral, antifungal, anti-inflammatory, anti-cancer and aldose reductase inhibitory activities. Keeping in mind the pharmacological potential of 2,4-Thiazolidinedione derivatives as antidiabetic agents, seven arylidene derivatives of 2,4-thiazolidinedione 1(a-g) and four corresponding acetic acid derivatives 2 (a-d) have been synthesized by a three-step procedure. Methods: All the synthesized compounds were characterized by elemental analysis, FTIR, 1 HNMR, and 13 CNMR and further screened for their α-amylase inhibitory potential. Results: All the compounds 1(a-g) and 2(a-d) showed varying degree of α-amylase inhibition, especially compound 1c (IC 50 = 6.59μg/ml), 1d (IC 50 =2.03μg/ml) and 1g (IC 50 = 3.14μg/ml) displayed significantly potent α-amylase inhibition as compared to the standard acarbose (IC 50 = 8.26μg/ml). None of the acetic acid derivatives of 5-arylidene-2,4-thiazolidinedione showed prominent inhibitory activity. Docking results indicated that the best binding conformation was found inside the active site cleft of enzyme responsible for hydrolysis of carbohydrates. Conclusion: Therefore, it can be concluded that 2,4-thiazolidinedione derivatives can be used as effective lead molecules for the development of α-amylase inhibitors for the management of diabetes.

Topic: Natural Antidiabetic Agents Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Employee Perceived Occupational Health and Safety Concerns at Phosphate Hill Fertiliser Plant

[Extract] As part of the James Cook University (JCU) study on the workplace environment and health at the Phosphate Hill fertiliser plant of Western Mining Corporation Fertilizers Pty Ltd (WMC), a qualitative research project comprising a series of seven focus groups and one semi-structured interview were conducted at the Phosphate Hill fertiliser plant in December 2001. As a follow up to this a further series of focus groups were conducted in September 2002 to determine if there had been any shift in some of the perceived occupational health and safety issues. These focus groups were also used as an opportunity to add some additional questions that would be used to assist the dehydration study, to assess employee perceptions about the change in rostering that has been implemented and also to assess perceptions and attitudes about the overall JCU study.

Topic: Occupational Health and Safety Research
Subfield: Radiological and Ultrasound Technology
Field: Health Professions
Domain: Health Sciences
Online Personal Training in Patients With Marfan Syndrome: A Randomized Controlled Study of Its Impact on Quality of Life and Physical Capacity

Background Marfan syndrome (MFS) is a genetic disorder affecting the vascular and musculoskeletal systems. Limited knowledge exists regarding the exercise benefits for this population. This study aimed to explore the impact of a structured exercise program on the quality of life (QoL) and physical capabilities of patients with MFS. Methods and Results This was a randomized, controlled, parallel‐group trial. Patients with MFS were randomized in a 1:1 ratio to either a training group or a control group. The trial included a 3‐month online supervised training program. Seventy patients with MFS were compared with healthy subjects. They were randomized into a training group (MFS‐T) and a control group (MFS‐C). The training consisted of 2 supervised online sessions weekly for 3 months. The primary outcome was QoL, assessed using the Medical Outcomes Study Short‐Form 36 questionnaire. Baseline QoL in all dimensions was lower in patients with MFS. Their peak oxygen uptake was 25% lower, and muscle elasticity was diminished compared with healthy subjects. Postintervention, significant improvements were observed in the MFS‐T group relative to the MFS‐C group: QoL (+20.2±14.3 versus +0.7±0.5), peak oxygen uptake (+34% versus +14%), muscle elasticity index (11.5±8.2 versus +1.2±1.7), reduced blood pressures during isometric squats (systolic −19±30 versus 0±6; diastolic −27±39 versus +2±15), and reduced pulse wave velocity at rest (−1.20±1.89 versus −0.40±1.61) and postexercise (−0.42±0.45 versus +0.08±0.48). The aortic diameter remained stable in both groups (MFS‐T−0.19±1.1 versus MFS‐C+0.11±0.78). After training, QoL remained lower in MFS‐T than in healthy subjects, but peak oxygen uptake, pulse wave velocity at rest, and postexercise were similar to those of healthy subjects. Conclusions The 3‐month online training program significantly enhanced QoL and cardiovascular/muscular metrics in patients with MFS without affecting aortic root diameter, suggesting its potential as part of a management strategy for MFS. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04553094.

Topic: Connective tissue disorders research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Round Robin of fire modelling for performance‐based design

Summary Nine participants, representing eight different Swedish fire consultancy firms participated in a Round Robin study where two different cases were simulated with the Fire Dynamics Simulator. The first case included a large open warehouse where the activation of a sprinkler system was to be studied. In the second case time to critical conditions in a theatre was to be calculated. The participants were given clear instructions on the building layout and heat release rate for the two cases. Still, the results demonstrate a significant variation in time to sprinkler system activation (range of 110 seconds) and available safe escape time (range of 60 seconds), between the participants. It is important to emphasise that some degree of variation is unavoidable, as engineers can model things differently without the modelling solution necessarily being incorrect. Even though it is hard to isolate and specific cause of the variation, some of the variation seen in this study is related to modelling choices that are questionable and consequently problematic for the reliability of the fire safety design.

Topic: Evacuation and Crowd Dynamics
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Protein Kinase C (PKC) Isozymes and Cancer

Protein kinase C (PKC) is a family of phospholipid-dependent serine/threonine kinases, which can be further classified into three PKC isozymes subfamilies: conventional or classic, novel or nonclassic, and atypical. PKC isozymes are known to be involved in cell proliferation, survival, invasion, migration, apoptosis, angiogenesis, and drug resistance. Because of their key roles in cell signaling, PKC isozymes also have the potential to be promising therapeutic targets for several diseases, such as cardiovascular diseases, immune and inflammatory diseases, neurological diseases, metabolic disorders, and multiple types of cancer. This review primarily focuses on the activation, mechanism, and function of PKC isozymes during cancer development and progression.

Topic: Protein Kinase Regulation and GTPase Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Effect of ZrO2 on Radiation Shielding Properties of xZrO2-(55-x) B2O3-15Bi2O3-10MgO-20PbO Glass: XCOM and Phy-X/PSD Database Software

This paper aims to determine the effect of ZrO2 on the parameters of glass-based radiation shielding with the molecular formula xZrO2-(55-x)B2O3-15Bi2O3-10MgO-20PbO (mole fraction, x= 0, 4, 8, 12, and 16 mol%). The parameters tested include Mass Attenuation Coefficients (MAC), Linear Attenuation Coefficient (LAC), Half-Value Layer (HVL), Tenth-Value Layer (TVL), Mean Free Path (MFP), and Effective Atomic Number (Zeff), which are measured using the XCOM and Phy-X/PSD programs in the energy range between 0.015 MeV and 15 MeV. The MAC values ​​obtained for all samples are between 0.0439-76.4100 cm2/g for 0ZrO, 0.0440-75.9300 cm2/g for 4ZrO, 0.0441-75.4700 cm2/g for 8ZrO, 0.0443-75.0200 cm2/g for 12ZrO, 0.0444-74.5800 cm2/g for 16ZrO. The difference in results between XCOM and Phy-X/PSD is very small, less than 0.1%. Compared with commercial shields such as RS-253-G18 glass shield and 40% synthetic borax radiation shield, ZrO2-based glass shield has better radiation capability. The 16ZrO sample has the best quality among all ZrO2-based glass shield samples at various radiation photon energies. This study is expected to be a reference in making glass radiation shields in further experiments. Keywords: Radiation Shielding, Zirconium Oxide, Bi2O3, XCOM, Phy-X/PSD, S

Topic: Radiation Shielding Materials Analysis
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
CCDC 2004053: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Estimating the dark halo mass from the relative thickness of stellar disks

We analyze the relationship between the mass of a spherical component and the minimum possible thickness of stable stellar disks. This relationship for real galaxies allows the lower limit on the dark halo mass to be estimated (the thinner the stable stellar disk is, the more massive the dark halo must be). In our analysis, we use both theoretical relations and numerical N-body simulations of the dynamical evolution of thin disks in the presence of spherical components with different density profiles and different masses. We conclude that the theoretical relationship between the thickness of disk galaxies and the mass of their spherical components is a lower envelope for the model data points. We recommend using this theoretical relationship to estimate the lower limit for the dark halo mass in galaxies. The estimate obtained turns out to be weak. Even for the thinnest galaxies, the dark halo mass within four exponential disk scale lengths must be more than one stellar disk mass. 1 1

Topic: Galaxies: Formation, Evolution, Phenomena
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Photoelectron diffraction study of O, N and C adsorption structures on Ni(100) and Cu(110)

Scanned energy mode adsorbate 1s photoelectron diffraction measurements have been taken from half-monolayer structures of O on Ni(100) and on Cu(110), and from C and N on Ni(100). The sensitivity of these data to the various structural parameters of these surface phases is investigated. In particular, the fact that 180° scattering contributions typically dominate the spectra in this form of the photoelectron diffraction experiment leads to a strong sensitivity to adsorbate–second layer substrate spacings. Even in the case in which the adsorbate and top substrate layers are nearly coplanar, however, some sensitivity to top layer geometry is retained, except in the case of the Cu(110) surface for which the lower rotational symmetry, combined with the plane polarisation of the incident radiation, leads to insensitivity to certain sites.

Topic: Electron and X-Ray Spectroscopy Techniques
Subfield: Surfaces, Coatings and Films
Field: Materials Science
Domain: Physical Sciences
First-price auctions, Dutch auctions, and buy-it-now prices with Allais paradox bidders

This paper investigates first-price and Dutch auctions when bidders have preferences exhibiting the Allais paradox. We characterize an equilibrium for both auctions, paying particular attention to the dynamic inconsistency problems which can arise with such preferences. We show that the Dutch auction systematically yields a higher revenue than the first-price auction. This stands in sharp contrast with the presumption that these auctions are strategically equivalent, which is indeed valid in the expected utility case. We also show that introducing a "buy-it-now-price" to the first-price auction increases seller's expected revenue when bidders have Allais paradox preference while it does not for expected-utility maximizers.

Topic: Auction Theory and Applications
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Character of cossack Kyrylo Tur in the deleted fragment of P. Kulish’s novel “Chorna rada” (“The Black Council: The Chronicle of 1663”)

The subject of the inquiry is editions and versions of the text of the novel “The Black Council: The Chronicle of 1663” by Panteleimon Kulish. The objective of the study is to analyze a fragment of the original edition (released in 1846), that was not included in the final text (released in 1857), peculiar in that it contains materials to characterize the image of the Cossack. Analysis of this fragment in the interpretive and textual planes provides for a better understanding of the creative method of P. Kulish as the author of the “The Black Council”. The methodology of the article comprises of a combination of source studies and comparative methods, which helps to solve the raised textual problems. In particular, the comparison of different editions reveals the effect of the “blind eye” when reading the final text: the omitted place correlates with the immediate context, and upon careful reading of the novel one could notice a possible omission, because its presence somewhat violates the logic of presentation. As a result, it has been revealed that the Russian-language equivalent of the fragment is contained in a magazine publication “Kyiv Pilgrims in the 17th Century” (1846). This text is a dialogue between hetman Yakym Somko, Cossack Kyrylo Tur, colonel-priest Ivan Shram and his friend Matvii Cherevan. V. Petrov’s statement that the writer “builds his novel by wide concentric closed motivational circles”, using the methods of refutations and oppositions, has been confirmed. In textual criticism terms, this fragment in the final version reveals the effect of the “blind eye” while reading the novel. Cherevan’s remark (that only in the Sich everybody knows how to “live the right way”) is in response to Tur’s statement that the Cossacks are hardy drinkers and Tur’s ignoring of Somko’s accusations that the Cossacks sit up to their neck in vodka in the final text are less motivated than in the original version. Also, it is revealed that the source of Tur’s statement is that the Sich Cossacks divide the spoils of war in three parts: to the needs of the church, to the military needs and Cossacks festivities and fun. The author used an allusion to the epic song [duma] about Samiilo Kishka. The analyzed fragment of the original edition is published for the first time, which determines the novelty of the study. The analysis of Kyrylo Tur’s image in this fragment is promising in connection with the forthcoming comprehensive study of the topic, which will become possible after the publication of all draft texts of both versions of the novel in Complete Works by P. Kulish.

Topic: Soviet and Russian History
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences