jimnoneill/paper-to-field-training huggingface dataset:
Study of Dual-Wavelength Mode Competition in an Erbium-Doped Fiber Laser (EDFL) Produced by Acoustic Waves

Distributed sensing using all-fiber laser-based acoustic sensors has been demonstrated recently for large area sensing. However, the sensitivity of this type of sensor has so far been much lower by comparison with currently available optical microphones. This paper studies the use of controlled interaction between the modes of oscillation in a fiber laser to enhance the sensitivity of acoustic wave detection. The responses of individual longitudinal modes to acoustic waves in a dual-wavelength fiber laser are demonstrated. With the experimental setup that has been developed, observation of a single wavelength output from the dual-wavelength laser shows optical responses to acoustic waves at 23 dB below the triggering threshold of laser dynamics, when compared with the previous scheme based on uncontrolled multimode operation.

Topic: Advanced Fiber Optic Sensors
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
10-Amino-9-(4-chlorophenyl)-3,3,6,6-tetramethyl-3,4,5,6,9,10-hexahydroacridine-1,8(2<i>H</i>,7<i>H</i>)-dione

The title compound, C23H27ClN2O2, has been synthesized by the reaction of 9-(4-chloro­phen­yl)-3,3,6,6-tetra­methyl-2,3,4,5,6,7-hexa­hydroxanthene-1,8-dione with hydrazine in ethanol under microwave irradiation. The dihydro­pyridine ring adopts a boat conformation.

Topic: Bioactive Compounds and Antitumor Agents
Subfield: Toxicology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Retinoic acid repression of cell-specific helix-loop-helix-octamer activation of the calcitonin/calcitonin gene-related peptide enhancer.

We have investigated the mechanism underlying repression of calcitonin/calcitonin gene-related peptide (CT/CGRP) gene expression by retinoic acid. Retinoic acid treatment of the CA77 thyroid C-cell line decreased CT/CGRP promoter activity two- to threefold, which correlates well with the decrease in calcitonin and CGRP mRNA levels. Repression is mediated through the nuclear retinoic acid receptors (RAR) on the basis of the retinoid specificity, the sensitivity of repression (half-maximal repression at 0.2 nM), and the additional repression caused by cotransfection of an alpha-RAR expression vector. The sequences required for retinoic acid repression were localized to an 18-bp element containing cell-specific enhancer activity. The enhancer binds helix-loop-helix (HLH) and octamer transcription factors that act synergistically to activate transcription. Retinoic acid repression requires both these factors since mutations in either motif resulted in the loss of repression. Furthermore, repression was observed only in cell lines containing enhancer activity. We have used electrophoretic mobility shift assays to show that repression does not involve direct DNA binding of RAR or RAR-retinoid X receptor heterodimers. Instead, repression appears to involve interactions with the stimulatory enhancer factors. Following retinoic acid treatment, there was a specific decrease in an enhancer complex containing both HLH and octamer proteins. Formation of the HLH-octamer complex was also specifically blocked by the addition of exogenous RAR-retinoid X receptor protein. These results demonstrate that RAR can repress CT/CGRP gene transcription by interfering with combinatorial activation by cell-specific HLH and octamer proteins.

Topic: Retinoids in leukemia and cellular processes
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Synthesis of Proviral DNA in Inbred Mouse-derived Clones of Cells Expressing Different Fv-1 Phenotypes

Formation of proviral DNAs by B-tropic murine leukaemia viruses (MLVs) was examined in N-type and dually permissive mutant cells derived from two inbred mouse strains, DDD and G, both of which are N-type. In the N-type cells, formation of circular proviral DNA was strongly suppressed relative to that of linear DNA. Mutation resulting in loss of the N-type Fv-1 restriction resulted in efficient formation of circular DNA by the previously restricted B-tropic MLV. This showed that Fv-1 restriction and inhibition of closed circular DNA formation were controlled by the same gene. The efficiency of formation of circular proviral DNA by the defective Kirsten murine sarcoma virus was determined by the tropism of the helper virus.

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Beliefs and Attitudes that Influence Learning

Mind, Brain, and Education (MBE) is a transdisciplinary area that joins neuroscience, psychology, and education to inform teaching practice and educational policy with research that can be translated into applicable and reflective tenets and principles of how students learn more effectively. It is well established in the MBE literature that what leads students to success are not only cognitive abilities but also beliefs and attitudes towards learning, which forms a complex and multifaceted universe with different levels of influence. This study has conducted a literature review on the contributions of MBE concerning these beliefs and attitudes and attempted to summarize them into a useful guide that might help students reflect on their academic achievement throughout life. Four essential elements were analysed and discussed, namely: growth mindset, metacognition, self-efficacy, and neuroplasticity. It is argued that these concepts are of paramount importance to anyone who wishes to accomplish both academic and career goals and they are aligned with the notion of lifelong learning.

Topic: Neuroscience, Education and Cognitive Function
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Congenital syngnathia in pediatric patient (virtual surgical planning in a pediatric patient with syngnathia): a case report and literature review

Congenital craniofacial disorders account for approximately 20% of all birth defects. One of the less common disorders is syngnathia. The case presented includes bony fusion of the alveolar processes of the maxilla and mandible and the ascending ramus with the zygomatic bone. This case report will present details from the gestational birth to the first month of age when the baby underwent the first attempt. to release syngnathia and postoperative control.

Topic: Cleft Lip and Palate Research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Distribution of Mallophaga on the body of Acridotheres tristis (Aves).

4 species of Mallophaga (2 Amblycera, Menacanthus eurysternus and Myrsidea sp., and 2 Ischnocera, Brueelia chayanh and Sturnidoecus affinis) coexist on the body of Common Myna, Acridotheres tristis. The distribution of eggs, nymphs and adults of these species on the body of host is discussed. The patterns of distribution coincides with their morphological adaptations.

Topic: Bird parasitology and diseases
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
KNOWLEDGE, ATTITUDE AND SKILLS OF NURSING STUDENTS REGARDING EVIDENCE BASED PRACTICE IN TERTIARY HOSPITALS

Evidence-based practice (EBP) is essential for improving healthcare outcomes by integrating clinical expertise, patient preferences, and research evidence. However, the adoption of EBP remains challenging, particularly in developing countries like Pakistan. Objective: To assess the knowledge, attitudes, and skills of nursing students regarding EBP in tertiary hospitals in Pakistan. Methods: A descriptive cross-sectional study was conducted among 150 nursing students using purposive sampling. Data were collected through a validated questionnaire and analyzed using SPSS version 26. Descriptive statistics were used to summarize demographic variables and EBP-related responses. Results: The majority of participants (46.2%) were aged 26-30 years, and most held a BSN qualification (43.1%). Knowledge about EBP was limited, with only 28.5% correctly defining it and 46.9% recognizing clinical practice guidelines as the most useful knowledge source. Attitudes were predominantly negative, with only 26.2% agreeing that EBP aids clinical decision-making. Skills assessment revealed that while 66.2% were confident in evaluating scientific articles, only 34.5% could formulate clinical questions for evidence searching. Conclusion: The findings highlight substantial gaps in EBP-related competencies among nursing students in Pakistan. Curriculum enhancements, mentorship programs, and improved access to research resources are urgently needed to address these deficiencies and promote the integration of EBP into nursing practice.

Topic: Health Sciences Research and Education
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Value of CT-Textural Features and Volume-Based PET Parameters in Comparison to Serologic Markers for Response Prediction in Patients with Diffuse Large B-Cell Lymphoma Undergoing CD19-CAR-T Cell Therapy

The goal of this study was to investigate the value of CT-textural features and volume-based PET parameters in comparison to serologic markers for response prediction in patients with diffuse large B-cell lymphoma (DLBCL) undergoing cluster of differentiation (CD19)-chimeric antigen receptor (CAR)-T cell therapy. We retrospectively analyzed the whole-body (WB)-metabolic tumor volume (MTV), the WB-total lesion glycolysis (TLG) and first order textural features derived from 18F-FDG-PET/CT, as well as serologic parameters (C-reactive protein [CRP] and lactate dehydrogenase [LDH], leucocytes) prior and after CAR-T cell therapy in 21 patients with DLBCL (57.7 ± 14.7 year; 7 female). Interleukin 6 (IL-6) and IL-2 receptor peaks were monitored after treatment onset and compared with patient outcome judged by follow-up 18F-FDG-PET/CT. In 12/21 patients (57%), complete remission (CR) was observed, whereas 9/21 patients (43%) showed partial remission (PR). At baseline, WB-MTV and WB-TLG were lower in patients achieving CR (35 ± 38 mL and 319 ± 362) compared to patients achieving PR (88 ± 110 mL and 1487 ± 2254; p &lt; 0.05). The “entropy” proved lower (1.81 ± 0.09) and “uniformity” higher (0.33 ± 0.02) in patients with CR compared to PR (2.08 ± 0.22 and 0.28 ± 0.47; p &lt; 0.05). Patients achieving CR had lower levels of CRP, LDH and leucocytes at baseline compared to patients achieving PR (p &lt; 0.05). In the entire cohort, WB-MTV and WB-TLG decreased after therapy onset (p &lt; 0.01) becoming not measurable in the CR-group. Leucocytes and CRP significantly dropped after therapy (p &lt; 0.01). The IL-6 and IL-2R peaks after therapy were lower in patients with CR compared to PR (p &gt; 0.05). In conclusion, volume-based PET parameters derived from PET/CT and CT-textural features have the potential to predict therapy response in patients with DLBCL undergoing CAR-T cell therapy.

Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Distributed Coordinated Precoding for MIMO Cellular Network Virtualization

This paper presents a new virtualization method for the downlink of a multi-cell multiple-input multiple-output (MIMO) network, to achieve service isolation among multiple Service Providers (SPs) that share the base station resources of an Infrastructure Provider (InP). Each SP designs a virtual precoder for its users in each cell, as its service demand to the InP, without the need to be aware of the existence of the other SPs or to know the channel state information (CSI) outside the cell. The InP performs network virtualization to meet the SPs' service demands while managing both the inter-SP and inter-cell interference. We consider coordinated multi-cell precoding at the InP and formulate an optimization problem to minimize a weighted sum of signal leakage and precoding deviation, with per-cell transmit power constraints. We propose a fully distributed semi-closed-form solution at each cell, without any CSI exchange across cells. We further propose a low-complexity scheme to allocate the virtual transmit power, for the InP to regulate between interference elimination and virtual demand maximization. Simulation results demonstrate that our precoding solution for network virtualization substantially outperforms the traditional spectrum isolation alternative. It can approach the performance of fully cooperative precoding when the number of antennas is large.

Topic: Advanced MIMO Systems Optimization
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Role of Investment Banks in Facilitating Initial Public Offerings (IPOs) in Emerging Markets: Challenges, Strategies, and Performance Analysis

Abstract This research paper explores the indispensable role played by investment banks in facilitating Initial Public Offerings (IPOs) in emerging markets, with a focus on India as a representative case. Utilizing a mixed-methods approach that integrates both quantitative survey data and qualitative thematic analysis, the paper examines the complex interplay between institutional frameworks, investment bank functions, and IPO outcomes. The findings underscore that investment banks play a central role in underwriting, pricing, regulatory compliance, marketing, investor engagement, and post-listing stabilization. Despite this significance, key challenges such as transparency deficits, regulatory delays, valuation disputes, and lack of investor education continue to persist. By evaluating empirical evidence and theoretical constructs, this paper contributes a holistic understanding of how investment banks shape IPO performance and proposes a set of actionable recommendations for stakeholders.

Topic: Private Equity and Venture Capital
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
6. Petra, its History and Monuments. By SirAlexander B. W. Kennedy, LL.D., F.R.S., F.R.G.S. 12½ × 9¾, xiv + 88, 212 plates and 4 maps. London: Country Life, 1925.

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Topic: Archaeology and Historical Studies
Subfield: Archeology
Field: Arts and Humanities
Domain: Social Sciences
Factors Influencing the Healing of Maxillary Sinusitis of Endodontic Origin After Non-Surgical Endodontic Treatment

Background/Objectives: The purpose of this study was to indicate factors influencing the healing of maxillary sinusitis of endodontic origin (MSEO) after non-surgical endodontic treatment. Methods: The study was performed retrospectively on medical records and CBCT data of 114 teeth in 114 patients, who were referred to endodontic treatment between 2016 and 2024, performed by the same operator and according to the same treatment protocol. Fifteen factors were chosen for their possible influence on the healing of MSEO. Results: The rate of the complete healing of MSEO after RCT was 76.32%. The healing of MSEO was higher when CHX was applied in the final irrigation protocol (p = 0.022) and was less likely when there was a flare-up in-between visits or after obturation of the canals (p = 0.002). MSEO was more likely to heal when a tooth was treated in two appointments than with single-visit RCT (p = 0.012). The number of endodontic interventions significantly influenced the healing of MSEO, as it was less likely to heal when there was more than one endodontic retreatment for a tooth (p = 0.01). Conclusions: Within the limitations of this retrospective study, four factors significantly influenced the healing of MSEO, and these should be taken into consideration in obtaining treatment protocols for dental-induced sinusitis and the better assessment of the possible success of this non-invasive treatment approach.

Topic: Endodontics and Root Canal Treatments
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Pseudooutbreak of Cedecea lapagei bacteremia in emergency room

Background: Cedecea lapagei is a very rare pathogen for human infection. There was only one report of prior isolation of C. lapagei from blood. We experienced a pesudooutbreak of C. lapagei bacteremia in emergency room (ER). We described the outbreak and outbreak investigation, along with performing genetic analysis of the isolated bacteria. Methods: From September 28 to November 5, 2009, 19 blood samples, which were collected from 11 patients in ER, were positive for C. lapagei. The 19 isolates showed similar antibiogram. The isolates were genotyped by pulsed-field gel electrophoresis (PFGE). We performed case-control study to identify risk factors of the outbreak. Environmental surveillance culture was performed to determine the source of the outbreak. Results: The case patients had been diagnosed with various different types of diseases at the time of the admission to ER. There was no influence in the clinical course of the patients even though proper antibiotics were not administered for C. lapagei. The PFGE results showed an indistinguishable pattern. In the results of case-control study, the case patients were older than the control patients (51.27 ± 23.31 years vs. 27.22 ± 28.54 years, P = o.oo7). The case patients had more drugs injected intravenously during staying in the ER than control patients (1.64 ± 1.57 vs. 0.38 ± 0.81, p < 0.001). The blood sampling of the case patients were performed by seven different interns. There were no significant differences in sex, chronic underlying diseases, use of a nebulizer, O2 supply, wound dressing, total parenteral nutrition, urinary catheter, central catheter, nasogastric tube, length of stay in ER before performing blood culture, and the area of the patients' staying in the ER. Among 73 environmental samples, there was no sample positive for C. lapagei. After the outbreak, the infection control unit instituted infection control measures including aseptic techniques, and no more outbreak of C. lapagei has been documented for one month in the ER. Conclusion: We suggested that multiple manipulations such as intravenous injection might be a risk factor of a pseudooutbreak and aseptic technique should be emphasized for preventing contamination. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive

Topic: Enterobacteriaceae and Cronobacter Research
Subfield: Endocrinology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
1507: IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME: REFRACTORY SHOCK TRIGGERED BY INFLUENZA B INFECTION

Zec, Simon; Garces, Juan Pablo Domecq; Jain, Nitesh; Khan, Syed Anjum Author Information

Topic: Immunodeficiency and Autoimmune Disorders
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Investigation and Reflection on the Living Conditions of Land-lost Farmers around Suburbs——Study on Liyuan village,eastern suburbs of Puer City,Yunnan Province

Since the 1990s,with the rapid development of urbanization in our country,a great amount of farmers have been swarming into cities.Therefore cities have been expanding, farming lands around cities have been taken over for use.The number of  land-lost farmers has been rapidly increasing.The changes of their living modes and living conditions as well as the process of urbanization are concerned by scholars and governments.

Topic: Regional Development and Environment
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
To feed, or not to feed? Evaluating enteral nutrition practices in surgical neonates

Background: Early enteral feeding initiation following surgical procedures in neonates has demonstrated several benefits. In high income countries, where parenteral nutrition is readily available, enteral feeding initiation is often delayed. This study seeks to examine clinical factors and decision-making processes that guide nutrition practices in surgical neonates in the United States (US) and Kenya. Methods: A REDCap survey was developed and distributed to pediatric surgery attendings and fellows at Riley and Peyton Manning Children’s Hospitals in Indiana (US) and Shoe4Africa Children’s and AIC Kijabe Hospitals in Kenya. Nine responses were collected during the initial two-week long pilot, then analyzed using REDCap and SPSS 25. Results: Responses were collected from eight pediatric surgery attendings and a fellow practicing in Indianapolis, IN. The three most highly ranked clinical factors important for initiation of enteral feeds were stability of the patient, nasogastric or orogastric output color, and gastric output volume. Factors most highly ranked for advancement of feeds included frequency and volume of emesis and abdominal distension. These factors were similarly ranked for foregut and hindgut procedures. Protocols for pyloric stenosis (n=6) include initiation of enteral nutrition within 24-48 hours. Four of nine respondents felt that surgeons at their institution are not aggressive enough in feeding surgical neonates. The primary perceived barrier to achieving full enteral nutrition was patient gut dysmotility (n=8). All respondents felt that they were similarly (n=4) or more (n=5) proactive in feeding surgical neonates compared to their peers. Conclusions and Impact: Feeding practices in surgical neonates are dependent on individual clinician decision-making processes and patient factors. Once the data from the Kenyan surgeons is collected, comparisons between practice patterns will be analyzed. Real-world enteral feeding practices will be evaluated in an adjunct observational study, which we hope will inform protocols with earlier enteral feeding initiation in the future.

Topic: Intestinal Malrotation and Obstruction Disorders
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
DARS-associated leukoencephalopathy can mimic a steroid-responsive neuroinflammatory disorder

Objective: To describe the expanding clinical spectrum of a recently described hereditary leuko-encephalopathy, hypomyelination with brainstem and spinal cord involvement and leg spasticity, which is caused by mutations in the aspartyl tRNA-synthetase encoding gene DARS, including patients with an adolescent onset.

Topic: RNA regulation and disease
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Russel Wright and Japan: Bridging Japonisme and Good Design through Craft

AbstractRussel Wright was an American designer who promoted the "American Modern" design and the "Good Design" movement from the 1930s through the 1950s. While he is familiar in the Western design context, his postwar involvement in Asia through the American foreign aid program promoting the idea of "Asian Modern" is little known. Wright and his associates gave the Japanese government advice on the promotion of handcraft, and informed the selection and modification of handcrafts for export to the United States. His advice pushed forward the official launch of the "Japanese Good Handcrafts Promotion Scheme," and subsequent implementation of design policy and system. This process also contributed to the development of the "Japanese Modern" style for craft-based design. In the context of the United States, Wright's Asian project can be seen not only as an extended experiment of the Good Design movement, but also a reflection of Japonisme, which formed an integral part of the modern American cultural identity. This article investigates the nature and extent of Wright's intervention in Japan with a particular focus on the way that the crafts facilitated cross-fertilization between ideas of nationality and the Good Design movements both in the United States and Japan.Keywords: Russel WrightJapancraftthe Good Design movementJaponismeCold War

Topic: Crafts, Textile, and Design
Subfield: Museology
Field: Arts and Humanities
Domain: Social Sciences