jimnoneill/paper-to-field-training huggingface dataset:
A case of pseudogout successfully treated with prednisolone and clarithromycin

To the Editor pseudogout (PG) is an acute arthritis induced by calcium pyrophosphate dihydrate crystal deposition, and it frequently develops in theelderly population. Non-steroidal anti-inflammatory drugs and/or corticosteroids, such as prednisolone (PSL), administered either by local intra-articular injection or systemic therapy remain the mainstay of PG treatment.1Macrolide antibiotics (MACs), such as clarithromycin (CAM) and azithromycin (AZM) provide not only antibacterial activity but also anti-inflammatory properties. Several recent studies reported the successful treatmentof rheumatoid arthritis2 and polymyalgia rheumatica3 using CAM as an anti-inflammatory agent. Herein, we describe a case of PG treated with PSLin combination with CAM, considering their anti-inflammatory properties.A 92-year-old female with Alzheimer’s disease, hypertension and osteoporosis presenting with fever, arthralgia and articular swellings in her bilateralshoulders, elbows, and wrists, was referred to our hospital. At the age of 91,she was diagnosed with PG by an orthopedic doctor. So far, she has experienced two PG attacks. The laboratory findings on this visit were as follows: white blood cell count, 8,990/μL (basophils, 0.3%; eosinophils, 1.0%;neutrophils, 78.4%; lymphocytes, 12.7%; and monocytes, 7.6%); C-reactive protein (CRP), 11.81 mg/dL; rheumatoid factor, 5 IU/L; anti-cyclic citrullinated peptide antibody, 0.5 U/mL; and antinuclear antibody titer, 1:40.A blood culture yielded negative results. No abnormal findings suggestiveof infection could be found in the systemic survey, including the chest roentgenogram and urinalysis. Bone roentgenogram revealed intra-articularcalcification compatible with PG. The aforementioned symptoms were similar to those of the previous PG attacks; therefore, the patient was diagnosed with PG attack. Initially, she was treated with acetaminophen (800mg/day), which was unsuccessful, although it was effective in the previousPG attacks. Therefore, she was treated with PSL (10 mg/day). Seven daysafter PSL treatment, fever and articular symptoms rapidly improved with adecreased CRP of 1.12 mg/dL. Therefore, the PSL dosage was decreasedto 7.5 mg/day. A week later, fever and articular symptoms relapsed with an

Topic: Hematological disorders and diagnostics
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Partial evaluation and automatic program generation

Functions, types and expressions programming languages and their operational semantics compilation partial evaluation of a flow chart languages partial evaluation of a first-order functional languages the view from Olympus partial evaluation of the Lambda calculus partial evaluation of prolog aspects of Similix - a partial evaluator for a subset of scheme partial evaluation of C applications of partial evaluation termination of partial evaluation program analysis more general program transformation guide to the literature the self-applicable scheme specializer.

Topic: Software Engineering Research
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Mixture GAN For Modulation Classification Resiliency Against Adversarial Attacks

Automatic modulation classification (AMC) using the Deep Neural Network (DNN) approach outperforms the traditional classification techniques, even in the presence of challenging wireless channel environments. However, the adversarial attacks cause the loss of accuracy for the DNN-based AMC by injecting a well-designed perturbation to the wireless channels. In this paper, we propose a novel generative adversarial network (GAN)-based countermeasure approach to safeguard the DNN-based AMC systems against adversarial attack examples. GAN-based aims to eliminate the adversarial attack examples before feeding to the DNN-based classifier. Specifically, we have shown the resiliency of our proposed defense GAN against the Fast-Gradient Sign method (FGSM) algorithm as one of the most potent kinds of attack algorithms to craft the perturbed signals. The existing defense-GAN has been designed for image classification and does not work in our case where the above-mentioned communication system is considered. Thus, our proposed countermeasure approach deploys GANs with a mixture of generators to overcome the mode collapsing problem in a typical GAN facing radio signal classification problem. Simulation results show the effectiveness of our proposed defense GAN so that it could enhance the accuracy of the DNN-based AMC under adversarial attacks to 81%, approximately.

Topic: Wireless Signal Modulation Classification
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Les Radios locales privées en France au travers de l’exemple du département de la Gironde. (1976 – 1986

Summary The development of the private local radios in Gironde, as at the national level, is done in a legislative context altered on several occasions but which is never used. The social phenomenon, marginal and claimant of the „free radios“ offering an anarchic character rediscovers quickly its proper laws of regulation which are essentially economic. At the experiences of associatives radios succeed the experiences of business radios with a very clear tendency at the concentration by the integration of the radios in national networks. We have to reflect on the reason which have permitted a such evolution so distant from the initial hopes.

Topic: Historical Studies and Socio-cultural Analysis
Subfield: History and Philosophy of Science
Field: Arts and Humanities
Domain: Social Sciences
Dermatological manifestations of tuberous sclerosis complex (TSC)

Summary Tuberous sclerosis complex (TSC) is a genetic multisystem disorder with prominent skin involvement that frequently occurs in early childhood. Dermatologic manifestations include facial angiofibromas, hypomelanotic macules, fibrous cephalic plaques, shagreen patches, and ungual fibromas. The International TSC Consensus Conference in 2012 provided guidelines for standardized baseline evaluation and follow‐up. Detailed clinical dermatological evaluation at the time of diagnosis and annual skin examination is recommended for both pediatric and adult populations. The onset of dermatological manifestations is clearly age‐related. However, dermatologists also have to assess for clinical manifestations beyond their own specialty. With advances in genetics and the advent of mTORC1 inhibitors, new specific therapeutic options have become available for TSC patients with skin manifestations. Early intervention is commonly recommended for symptomatic, rapidly evolving, disfiguring, or debilitating lesions. The consensus guidelines recommend “treatment as appropriate for the lesion and clinical context” and suggest the use of surgical excision, laser therapy, or topical mTORC1 inhibitors. Topical mTORC1 inhibitors present a useful option for TSC‐associated skin lesions, particularly in medically complex patients. They may prevent or reduce the risks of subsequent surgeries and permanent scarring.

Topic: Tuberous Sclerosis Complex Research
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
CCDC 856971: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Cavitation on single electron bubbles in liquid helium at small negative pressure

Liquid helium under negative pressure represents a unique possibility for studying the macroscopic quantum nucleation phenomena in condensed media. We analyze the quantum cavitation rate of single electron bubbles at low temperatures down to absolute zero. The energy dissipation and sound emission processes result in the different temperature behavior of quantum cavitation rate in normal fluid $^3$He and superfluid $^4$He below the thermal-quantum crossover temperature. The position of rapid nucleation line in the temperature-pressure phase diagram is discussed as well.

Topic: Quantum, superfluid, helium dynamics
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
The Curated Food System: A Limiting Aspirational Vision of What Constitutes “Good” Food

In an effort to elucidate an aspirational vision for the food system and explore whether the characteristics of such a system inadvertently set unattainable standards for low-wealth rural communities, we applied discourse analysis to the following qualitative datasets: (1) interviews with food experts and advocates, (2) scholarly and grey literature, (3) industry websites, and (4) email exchanges between food advocates. The analysis revealed eight aspirational food system discourses: production, distribution, and infrastructure; healthy, organic, local food; behavioral health and education; sustainability; finance and investment; hunger relief; demand-side preferences; romanticized, community led transformations. Study findings reveal that of eight discourses, only three encompass the experiences of low-wealth rural residents. This aspirational food system may aggravate the lack of autonomy and powerlessness already experienced by low-wealth rural groups, perpetuate a sense of failure by groups who will be unable to reach the aspirational food vision, silence discourses that might question those that play a role in the inequitable distribution of income while sanctioning discourses that focus on personal or community solutions, and leave out other policy-based solutions that address issues located within the food system. Further research might explore how to draw attention to silenced discourses on the needs and preferences of low-wealth rural populations to ensure that the policies and programs promoted by food system experts mitigate poor diets caused by food insecurity. Further research is needed to inform policies and programs to mitigate food insecurity in low-wealth rural populations.

Topic: Food Security and Health in Diverse Populations
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Thermal Spray Coating: A Study

Surface coating is a reliable and cost effective process, used for the production of tools, materials, and machine components that requires desired surface properties like corrosion, erosion and wear resistance. The main purpose of applying the coating may be decorative, functional, or both. To improve surface properties such as adhesion, erosion, corrosion and wear resistance, functional coating may be used. Whereas, decorative coating such as artists paints are applied to make the product/material more attractive. Now days, number of coating methods are applied to achieve the desired functional or decorative properties. Thermal spray coating process is one of the effective and attractive methods to preserve/protect the new machine components from wear, hot corrosion, and erosion. This paper briefly explains various spray processes, their basic principles, advantages, and applications. In addition to this features, characteristics of coating methods and various corrosion prevention methods are briefly described..

Topic: High-Temperature Coating Behaviors
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
The Use and Abuse of Unjust Enrichment. Essays on the Law of Restitution. By J. Beatson. [Oxford: Clarendon Press. 1991. xxviii, 258 and (Index) 5pp. Hardback £35·00 net.]

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.

Topic: Legal principles and applications
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Diagonalisation conjointe non négative par congruence pour l'analyse en composantes indépendantes semi-non négative

La Diagonalisation Conjointe par Congruence (DCC) d'un ensemble de matrices apparaît dans nombres de problèmes de traitement du signal, tels qu'en Analyse en Composantes Indépendantes (ACI). Les développements récents en ACI sous contrainte de non négativité de la matrice de mélange, nommée ACI semi-non négative, permettent de tirer profit d'une modélisation physique réaliste des phénomènes observés tels qu'en audio, en traitement d'image ou en ingénierie biomédicale. Par conséquent, durant cette thèse, l'objectif principal était non seulement de concevoir et développer des algorithmes d'ACI semi-non négative basés sur de nouvelles méthodes de DCC non négative où la matrice de passage recherchée est non négative, mais également d'illustrer leur intérêt dans le cadre d'applications pratiques de séparation de sources. Les algorithmes de DCC non négative proposés exploitent respectivement deux stratégies fondamentales d'optimisation. La première famille d'algorithmes comprend cinq méthodes semi-algébriques, reposant sur la méthode de Jacobi. Cette famille prend en compte la non négativité par un changement de variable carré, permettant ainsi de se ramener à un problème d'optimisation sans contrainte. L'idée générale de la méthode de Jacobi est de i) factoriser la matrice recherchée comme un produit de matrices élémentaires, chacune n'étant définie que par un seul paramètre, puis ii) d'estimer ces matrices élémentaires l'une après l'autre dans un ordre spécifique. La deuxième famille compte un seul algorithme, qui utilise la méthode des directions alternées. Un tel algorithme est obtenu en minimisant successivement le Lagrangien augmenté par rapport aux variables et aux multiplicateurs. Les résultats expérimentaux sur les matrices simulées montrent un gain en performance des algorithmes proposés par comparaison aux méthodes DCC classiques, qui n'exploitent pas la contrainte de non négativité. Il semble que nos méthodes peuvent fournir une meilleure précision d'estimation en particulier dans des contextes difficiles, par exemple, pour de faibles valeurs de rapport signal sur bruit, pour un petit nombre de matrices à diagonaliser et pour des niveaux élevés de cohérence de la matrice de passage. Nous avons ensuite montré l'intérêt de nos approches pour la résolution de problèmes pratiques de séparation aveugle de sources. Pour n'en citer que quelques-uns, nous sommes intéressés à i) l'analyse de composés chimiques en spectroscopie par résonance magnétique, ii) l'identification des profils spectraux des harmoniques (par exemple, de notes de piano) d'un morceau de musique mono-canal par décomposition du spectrogramme, iii) l'élimination partielle du texte se trouvant au verso d'une feuille de papier fin. Ces applications démontrent la validité et l'intérêt de nos algorithmes en comparaison des méthodes classique de séparation aveugle de source.

Topic: Blind Source Separation Techniques
Subfield: Signal Processing
Field: Computer Science
Domain: Physical Sciences
The opioid peptide dynorphin suppresses pituitary‐ovary axis in the tilapia <scp><i>Oreochromis mossambicus</i></scp>

Abstract The opioid peptides are involved in the regulation of neuroendocrine functions in vertebrates. Nonetheless, the influence of an opioid peptide, dynorphin A (DYN), on reproduction in fish is understudied. The aim of this work was to study the influence of DYN on the pituitary‐ovary axis in Oreochromis mossambicus . Daily injections (ip) of 250 μg DYN kg −1 body weight for 22 days during the ovarian cycle caused a reduction in the intensity and the per cent area of luteinizing hormone (LH) immunoreactive content in the proximal pars distalis region of the pituitary gland compared with an intense immunostaining in time‐matched controls. In the ovary, DYN treatment caused a decrease in the number of stage I (previtellogenic) follicles compared with time‐matched controls. No difference was observed in the number of stage IV (vitellogenic) follicles among different experimental groups, whereas the numbers of stage II and stage III follicles (previtellogenic) were higher in DYN‐treated fish than in time‐matched controls. Nonetheless, there was a reduction in the number of stage V (preovulatory) follicles in DYN‐treated fish compared with time‐matched controls. Taken together, these results indicate that DYN exerts an inhibitory effect on follicular recruitment at the late vitellogenic stage, through the suppression of LH secretion in fish.

Topic: Reproductive biology and impacts on aquatic species
Subfield: Physiology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Temperature dependent transport behavior of n-InN nanodot/p-Si heterojunction structures

The present work explores the temperature dependent transport behavior of n-InN nanodot/p-Si(100) heterojunction diodes. InN nanodot (ND) structures were grown on a 20 nm InN buffer layer on p-Si(100) substrates. These dots were found to be single crystalline and grown along [001] direction. The junction between these two materials exhibits a strong rectifying behavior at low temperatures. The average barrier height (BH) was determined to be 0.7 eV from current-voltage-temperature, capacitance-voltage, and flat band considerations. The band offsets derived from built-in potential were found to be ΔEC=1.8 eV and ΔEV=1.3 eV and are in close agreement with Anderson’s model.

Topic: GaN-based semiconductor devices and materials
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Locally curved quantum layers

We consider a quantum particle constrained to a curved layer of a constant width built over an infinite smooth surface. We suppose that the latter is a locally deformed plane and that the layer has the hard-wall boundary. Under this assumptions we prove that the particle Hamiltonian possesses geometrically induced bound states.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
ASSESSING THE EFFECT OF COHORT, GENDER, AND RACE ON DIFFERENTIAL ITEM FUNCTIONING (DIF) IN AN ADAPTIVE TEST DESIGNED FOR MULTI-AGE GROUPS

Differential item functioning (DIF) statistics were computed using items from the Peabody Individual Achievement Test (PIAT)-Reading Comprehension subtest for children of the same age group (ages 7 through 12 respectively). The pattern of observed DIF items was determined by comparing each cohort across age groups. Differences related to race and gender were also identified within each cohort. Characteristics of DIF items were identified based on sentence length, vocabulary frequency, and density of a sentence. DIF items were more frequently associated with short sentences than with long sentences. This study explored the potential limitation in the longitudinal use of items in an adaptive test.

Topic: Educational and Psychological Assessments
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
A New Optical Technique to Study Aerosol Phase Transitions:  The Nucleation of Ice from H<sub>2</sub>SO<sub>4</sub> Aerosols

A new optical microscope technique has been developed to investigate phase transitions in micrometer-sized droplets. This technique has been used to study the nucleation of ice from aqueous H2SO4 aerosols 0−35 wt % in composition in the temperature range from 273 to 170 K. The aerosols were produced with a nebulizer and were deposited on a quartz plate, which was coated with a hydrophobic silane monolayer to minimize the effects of heterogeneous nucleation. More than 1200 aerosol particles were monitored individually with the optical microscope, and their freezing temperatures and melting points were recorded. The observed freezing temperatures are lower than the ones from comparable aerosol studies reported in the literature, the differences in the freezing temperature being up to 30 K, especially for the more concentrated aerosols. No freezing was observed above 170 K for compositions greater than 27 wt %. A thermodynamic model has been used to apply the new freezing temperature data to the formation of clouds in the upper troposphere and lower stratosphere. The results indicate that the homogeneous nucleation of ice particles in cirrus clouds requires saturation ratios with respect to ice ranging from about 1.5 at 230 K to 1.6 at 205 K. In addition, the formation of type II polar stratospheric clouds under volcanically perturbed conditions where H2SO4 is the main aqueous aerosol component at low temperatures is predicted to occur about 3 K below the ice frost point.

Topic: Atmospheric chemistry and aerosols
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
The <i>m</i>/<i>z</i> 91 rearrangement ion in the mass spectra of some 1,4‐benzodiazepines

Abstract With the aid of isotope labeling and by substituent shifts, the relatively strong m/z 91 ion in the mass spectra of 7‐chloro‐2‐methoxy‐5‐phenyl‐3 H ‐1,4‐benzodiazepine and related compounds was shown to contain the 5‐phenyl ring and the 3‐CH 2 group. Mechanisms involving the opening of the 7‐membered ring and the migration of the phenyl ring from C‐5 to C‐3 are postulated for the formation of this ion. This rearrangement ion was also observed in the mass spectra of some 1‐alkyl‐7‐chloro‐1,3‐dhydro‐5‐phenyl‐2 H ‐1,4‐benzodiazepin‐2‐ones.

Topic: Nonlinear Optical Materials Research
Subfield: Electronic, Optical and Magnetic Materials
Field: Materials Science
Domain: Physical Sciences
Figure S5 from Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis

&lt;p&gt;Small extracellular vesicles derived from MDA-MB-468 DXR-treated cells prime the pre-metastatic niche.&lt;/p&gt;

Topic: Biomarkers in Disease Mechanisms
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Evaluating the Effectiveness of Clinical Supervision in the Care Coordination Workforce

Clinical supervision is noted in other fields as instrumental to attaining better outcomes for people who receive care. This study which occurred in New York State during the COVID-19 pandemic, explored using the Manchester Clinical Supervision Scale (MCSS-26) alignments between the perceptions of care coordinators and care coordinators’ supervisors of the effectiveness of clinical supervision in the health home context, the impact of COVID-19 on clinical supervision sessions, increased remote care coordination, and best practices of clinical supervision in the health home. Findings revealed differences in perceptions of the effectiveness of clinical supervision and of the impact of COVID-19 on clinical supervision. There were alignments on MCSS-26 subscales of “Importance and Value of Supervision,” “Finding time,” and “Trust and Rapport” and on the effectiveness of the increase in remote care coordination. However, misalignments were significant on the MCSS-26 subscales of “Improve Care,” “Reflection,” “Supervisor Support and Advice” and the overall perception of the effectiveness of clinical supervision. There was further misalignment in the perceptions of care coordinators of the impact of COVID-19 on clinical supervision. However, few care coordinators and most of the care coordinators supervisors’ satisfaction remain the same with both in-person clinical supervision and telesupervision during COVID-19. Finally, findings revealed that current supervisory practices did not mirror best practices of clinical supervision in the area of discussion of topic related to self during clinical supervision while practices such as the frequency, duration of clinical sessions, and discussion of client care mirrored best practices of clinical supervision.

Topic: Nursing Roles and Practices
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences