jimnoneill/paper-to-field-training huggingface dataset:
Lockwood's Dreams and the Key to Wuthering Heights

Research Article| June 01 1969 Lockwood's Dreams and the Key to Wuthering Heights Ronald E. Fine Ronald E. Fine Search for other works by this author on: This Site PubMed Google Scholar Nineteenth-Century Fiction (1969) 24 (1): 16–30. https://doi.org/10.2307/2932349 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ronald E. Fine; Lockwood's Dreams and the Key to Wuthering Heights. Nineteenth-Century Fiction 1 June 1969; 24 (1): 16–30. doi: https://doi.org/10.2307/2932349 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentNineteenth-Century Literature Search This content is only available via PDF. Copyright 1969 By The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Short Stories in Global Literature
Subfield: Literature and Literary Theory
Field: Arts and Humanities
Domain: Social Sciences
Supplementary_material – Supplemental material for Revisiting the Effect of Varying the Number of Response Alternatives in Clinical Assessment: Evidence From Measuring ADHD Symptoms

Supplemental material, Supplementary_material for Revisiting the Effect of Varying the Number of Response Alternatives in Clinical Assessment: Evidence From Measuring ADHD Symptoms by Dexin Shi, E. Rebekah Siceloff, Rebeca E. Castellanos, Rachel M. Bridges, Zhehan Jiang, Kate Flory and Kari Benson in Assessment

Topic: Attention Deficit Hyperactivity Disorder
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Specification Analysis of Affine Term Structure Models

In this paper, we explore the features of affine term structure models that are empirically important for explaining the joint distribution of yields on short and long-term interest rate swaps. We begin by showing that the family of N-factor affine models can be classified into N+1 non-nested sub-families of models. For each sub-family, we derive a maximal model with the property that every admissible member of this family is equivalent to or a nested special case of our maximal model. Second, using our classification scheme and maximal models, we show that many of the three-factor models in the literature impose potentially strong over-identifying restrictions on the joint distribution of short- and long-term rates. Third, we compute simulated method-of-moments estimates for several members of one of the four branches of three-factor models, and test the over-identifying restrictions implied by these models. We conclude that many of the extant affine models in the literature fail to describe important features of the distribution of long- and short- term rates. The source of the model misspecification is shown to be overly strong restrictions on the correlations among the state variables. Relaxing these restrictions leads to a model that passes several goodness-of-fit tests over our sample period.

Topic: Probability and Risk Models
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Optimization Design for Structure of a Shroud Base on Fluent

This paper reports a CFD modeling study on the optimization design for the shroud structure of a three-phase electroslag furnace using double electrode series technique by a commercial code FLUENT. The Realizable kε turbulence model, Do radiation model and Mixture model are amply used to compute the flow of gases in the furnace under different entrance layouts of the shroud, and the influence of entrance layout on the air volume fraction in the furnace is obtained. Finally, a suited suggestion on the entrance layout of shroud is presented that ring topologies should be adopted.

Topic: Metallurgical Processes and Thermodynamics
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Relationships between the health of Alaska Native communities and our environment -- phase 1, exploring and communicating

Alaska Natives depend on local natural resources for nutritional and, for many, spiritual health. As a result, public health in Alaska is strongly influenced by the relationship between people and their surrounding physical, chemical, and biological environments. Alaska is vast with diverse wildlife and plant communities that are valued as subsistence foods (fig. 1). These resources are supported by equally diverse ecosystems and their underpinning landforms and geologies. The U.S. Geological Survey (USGS) is attempting to integrate physical, chemical, and biological information to better describe current (2013) environments and project scenarios for the future. Integrating ecological data into the public health dialogue is challenging for the more than 280 rural communities of Alaska. This fact sheet reviews a recent USGS effort, the Geographic Information System (GIS) Native Health Project, to better incorporate scientific information into such dialogue.

Topic: Indigenous Studies and Ecology
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Protists and Multiple Routes to the Evolution of Multicellularity

The aim of this chapter is to ask what aspects pertaining to the evolutionary origin of multicellular life might be inferred from a survey of otherwise dissimilar protists that display one or both of two features: a unicellular-to-multicellular transition as part of their normal life cycle, or membership of a closely related group that contains both unicellular and multicellular members. Accordingly, we highlight aspects of multicellular development in three different "supergroups" of eukaryote protists: Dictyostelid or cellular slime molds (CSMs) (supergroup Amoebozoa, Mycetozoa; Section 4.2); Choanoflagellates, Filastareans, and Icthyosporeans (Opisthokonta, unicellular Holozoa; Section 4.3); and Volvocine green algae (Archaeplastida, Chlorophyceae; Section 4.4); their last common ancestor is believed to lie at the very root of the evolutionary tree of eukaryotes (Burki). In the first two, multicellularity is achieved by the aggregation of single cells, in the third, by the products of cell division staying together.

Topic: Coccidia and coccidiosis research
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Adaptive evolution of a candidate gene for aging in\n Drosophila

Examination of the phenotypic effects of specific mutations has\n been extensively used to identify candidate genes affecting traits of\n interest. However, such analyses do not reveal anything about the\n evolutionary forces acting at these loci, or whether standing allelic\n variation contributes to phenotypic variance in natural populations.\n The Drosophila gene methuselah\n (mth) has been proposed as having major effects on\n organismal stress response and longevity phenotype. Here, we examine\n patterns of polymorphism and divergence at mth in\n population level samples of Drosophila melanogaster,\n D. simulans, and D. yakuba. Mth has\n experienced an unusually high level of adaptive amino acid divergence\n concentrated in the intra- and extracellular loop domains of the\n receptor protein, suggesting the historical action of positive\n selection on those regions of the molecule that modulate signal\n transduction. Further analysis of single nucleotide polymorphisms\n (SNPs) in D. melanogaster provided evidence for\n contemporary and spatially variable selection at the mth\n locus. In ten surveyed populations, the most common mth\n haplotype exhibited a 40% cline in frequency that coincided with\n population level differences in multiple life-history traits including\n lifespan. This clinal pattern was not associated with any particular\n SNP in the coding region, indicating that selection is operating at a\n closely linked site that may be involved in gene expression. Together,\n these consistently nonneutral patterns of inter- and intraspecific\n variation suggest adaptive evolution of a signal transduction pathway\n that may modulate lifespan in nature.

Topic: Genetics, Aging, and Longevity in Model Organisms
Subfield: Aging
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Statistical Challenges in Modern Astronomy II

This work may not bc tronslatoo or copicd in whole or in pan without the writtro pcrmission ofthe publisher (Springcr-SeirocL'+l3usiness Media.LLC), except for brief cxecrpts in eonncction with revicws or scholarly analysis.Usc in eonncction with any fonn of information storage ami rctrie\'al.dcctronic adaptation, computer software.or hy similar or dissimilar mcthodology now known or hcrcaficr developcd is forbidden.The usc of general dcscriptive names.

Topic: Probability and Statistical Research
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Thoracoscopic treatment of persistent right aortic arch in dogs with and without one lung ventilation

Abstract Objective To evaluate thoracoscopic treatment of persistent right aortic arch (PRAA) in dogs with and without the use of one lung ventilation (OLV). Study Design Retrospective cohort study. Animals Twenty‐two (client‐owned and shelter) dogs diagnosed with PRAA. Methods Medical records were reviewed retrospectively and intraoperative and immediate postoperative data were compared between dogs that underwent thoracoscopic treatment of PRAA with (OLV+) and without (OLV‐) OLV. Results Ten of the 12 dogs in the OLV+ group and 7/10 dogs in the OLV− group had their left ligamentum arteriosum successfully ligated during thoracoscopy. Median surgical time, surgery complications, anesthesia complications, and rate of conversion to an open thoracotomy due to limited visualization or surgical complications were similar between the two groups. Conclusion Thoracoscopic treatment of PRAA can be performed with or without OLV. Surgical time, intraoperative complications, and conversion rates were similar between dogs that underwent thoracoscopic treatment of PRAA with and without OLV. OLV may not have contributed to improved visualization in this group of dogs. Clinical Significance (or Impact) The use of OLV is safe during thoracoscopic treatment of PRAA. OLV did not appear to provide significant benefits in this case series and thoracoscopic treatment of PRAA in dogs may be performed successfully with or without the use of OLV.

Topic: Tracheal and airway disorders
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Community pharmacists’ knowledge and practices towards antimicrobial stewardship: findings and implications

Abstract Background Antimicrobial stewardship (AMS) programmes have been implemented around the world to optimally manage antimicrobial use to attenuate antimicrobial resistance (AMR). This study assessed the knowledge and practices of community pharmacists towards AMS strategies in the Lusaka District, Zambia. Methods This cross-sectional study was conducted among 194 community pharmacists in the Lusaka district using a structured questionnaire from August 2022 to September 2022. Data analysis was done using Statistical Package for Social Science (SPSS) version 22.0. Results Of the 194 participants, 86% of the community pharmacists had good knowledge of AMS. The present study found that 83.5% were aware of AMS strategies used in community pharmacy practice. Further, 83.5% of the CPs were familiar with the goals of AMS and 89.2% believed that AMS was necessary for their pharmacy practice. Furthermore, 66.7% of the participants exhibited good practice towards the AMS strategies. Finally, 61.3% frequently avoided the use of broad-spectrum antimicrobials that were not necessary. Conclusions According to the findings of this study, the majority of community pharmacists had good knowledge of the AMS strategies that were employed to combat AMR; nonetheless, some of them had poor practices. Therefore, there is a need for community pharmacists to have access to sufficient ongoing professional development programmes and educational activities through AMS programmes to address AMR.

Topic: Antibiotic Use and Resistance
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Quality Improvement: A Strategyfor Planned Organizational Change

IN ADDITION TO DETERMININGEXACTLY what quality improvement means in a library environment, there is the challenge of identifying and using an appropriate strategy for implementation. Among the factors that can delay or even prevent adoption of quality improvement efforts, such as Total Quality Management (TQM), is fear that the adoption itself may fail. This fear is well founded; many organizations, among them libraries, have a history of starting and then abandoning planned change. Even with the best of intentions-i.e., carefully developed plans and seeming commitment to the ideals of quality-not every implementation is successful. An examination of the literature of change offers several major perspectives on effecting organizational change and yields insights that can be overlaid on the foundations of continuous improvement; taken together, these then suggest strategies by which adoption of quality improvement can be undertaken successfully. By viewing the adoption of an improvement strategy as two distinct but related challenges-one dealing with the philosophy and values of the library and the other with the technical requirements of TQM tools and processes-the adopting library will increase the probability of its selecting and using appropriate strategies. Of necessity, these strategies must be situation specific, but some possible strategies for libraries to use are identified.

Topic: Irish and British Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Moderating Effect of Audit Committee Financial Expertise on the Relationship between Audit Quality and Earnings Management of Quoted Consumer Goods Firms in Nigeria

This study examined the moderating effect of audit committee financial expertise on the relationship between audit quality and earnings management among quoted consumer goods companies in Nigeria. Earnings management as dependent variable was proxied by discretionary accruals while audit quality is explained using audit fees and auditor industry specialization.The study adopted Ex post facto research design. Population included all the 21 companies in the consumer goods sector. The study purposively, sampled 17 out of the entire population for the purpose of data collection. The study covered the period 2012 to 2021. Secondary data were extracted from the annual accounts of the companies for the period of the study. The study employed the use of multiple regression technique to analyse the data. The result of the study showed that both audit fees and auditor industry specialization have positive significant relationship with earnings management when moderated by audit committee financial expertise. The study concluded that both variables can be used as determinants of real earnings management when there is a financial expert on the audit committee. From the findings, it was recommended that efforts should be made with respect to legislations to strengthen auditors’ quality in Nigeria by ensuring that audit committee members have financial expertise since it is a viable corporate governance tool towards enhancing reported earnings quality.

Topic: Auditing, Earnings Management, Governance
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
16 Reaching Out – Engagement Through Events and Festivals – The Cathedrals of England

All religions are characterised by a focus around a calendar of events yet the degree to which religion permeates the event and festival sector is much overlooked and frequently misunderstood. Traditionally, religious events closely follow the cycle of sacred beliefs which underpin the faiths but there has also been a strong link with the celebration of the seasons and harvests. In Christianity, Easter and Christmas have formed the backbone of the event calendar for centuries and Lent is preceded by the busy Carnival season, especially in Catholic countries. These religious festivals have become ever more elongated, commercialised and exploited by wider society. This in itself is an interesting and long standing trend but this chapter will concentrate its analytical eye on the link between the Christian church and the burgeoning event sector of the early twenty first century. It will focus on (Anglican) Cathedrals in England and investigate the extent to which these great institutions and buildings have harnessed their centuries-old skills and knowledge in the staging of events to explore new ways of reaching out to diverse audiences, whether local residents, tourists or pilgrims. It will reflect on the challenges and tensions which cathedrals must overcome to diversify their event portfolios and consider why events have become a much more significant aspect of their activity and mission. This review is underpinned by the author’s professional interest in events and festivals and his own experience in managing a cathedral city destination (Rochester, in the south-east of England). This has been supported by secondary research and through a series of interviews and discussions with senior cathedral representative during the summer of 2015. While the case studies are drawn from Anglican cathedrals, the trends and issues revealed have implications for cathedrals in Europe and beyond.

Topic: Religious Tourism and Spaces
Subfield: Geography, Planning and Development
Field: Social Sciences
Domain: Social Sciences
Molecular Evolution of Vertebrate Neurotrophins: Co-Option of the Highly Conserved Nerve Growth Factor Gene into the Advanced Snake Venom Arsenalf

&lt;div&gt;&lt;p&gt;Neurotrophins are a diverse class of structurally related proteins, essential for neuronal development, survival, plasticity and regeneration. They are characterized by major family members, such as the nerve growth factors (NGF), brain-derived neurotrophic factors (BDNF) and neurotrophin-3 (NT-3), which have been demonstrated here to lack coding sequence variations and follow the regime of negative selection, highlighting their extremely important conserved role in vertebrate homeostasis. However, in stark contrast, venom NGF secreted as part of the chemical arsenal of the venomous advanced snake family Elapidae (and to a lesser extent Viperidae) have characteristics consistent with the typical accelerated molecular evolution of venom components. This includes a rapid rate of diversification under the significant influence of positive-selection, with the majority of positively-selected sites found in the secreted β-polypeptide chain (74%) and on the molecular surface of the protein (92%), while the core structural and functional residues remain highly constrained. Such focal mutagenesis generates active residues on the toxin molecular surface, which are capable of interacting with novel biological targets in prey to induce a myriad of pharmacological effects. We propose that caenophidian NGFs could participate in prey-envenoming by causing a massive release of chemical mediators from mast cells to mount inflammatory reactions and increase vascular permeability, thereby aiding the spread of other toxins and/or by acting as proapoptotic factors. Despite their presence in reptilian venom having been known for over 60 years, this is the first evidence that venom-secreted NGF follows the molecular evolutionary pattern of other venom components, and thus likely participates in prey-envenomation.&lt;/p&gt; &lt;/div&gt;

Topic: Venomous Animal Envenomation and Studies
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes.

Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung function but gastrointestinal effects are unclear. We aimed to see if a CFTR modulator (tezacaftor-ivacaftor,TEZ/IVA) improves gastrointestinal outcomes in CF. Methods We conducted a randomised, double-blind, placebo-controlled, two-period crossover trial (2019-2020) at Nottingham University Hospitals. The effects of TEZ/IVA on gut physiology were measured using MRI. Participants were randomly assigned to treatment sequences AB or BA (A:TEZ/IVA, B:placebo, each 28 days), with a 28-day washout period. Participants had serial MRI scans at baseline and after 19-23 days of each treatment. Due to the COVID-19 pandemic, a protocol amendment allowed for observer-blind comparisons prior to and during TEZ/IVA. In such cases, participants were not blind to the treatment but researchers remained blind. The primary outcome was oro-caecal transit time (OCTT). Secondary outcomes included MRI metrics, symptoms and stool biomarkers. Results We randomised 13 participants. Before the COVID-19 pandemic 8 participants completed the full protocol and 1 dropped out. The remaining 4 participants followed the amended protocol. There were no significant differences between placebo and TEZ/IVA for OCTT (TEZ/IVA >360minutes [225,>360] vs. placebo 330minutes [285,>360], p=0.8) or secondary outcomes. There were no adverse events. Conclusions Our data contribute to a research gap in the extra-pulmonary effects of CFTR modulators. We found no effect after TEZ/IVA on MRI metrics of gut function, GI symptoms or stool calprotectin. Effects might be detectable with larger studies, longer treatment or more effective CFTR modulators. ClinicalTrials.gov registration NCT04006873 (02/07/2019)

Topic: Cystic Fibrosis Research Advances
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Incidence of Atrial Fibrosis in Non-Valvular Atrial Fibrillation Patients and its Impact on Recurrence after Pulmonary Vein Antral Isolation

The presence of the atrial fibrosis in the left atrium is an independent predictor of atrial fibrillation recurrence after pulmonary vein antrum isolation after 6 months without left atium substrate modification.

Topic: Atrial Fibrillation Management and Outcomes
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences