jimnoneill/paper-to-field-training huggingface dataset:
Analyses of locomotion, wing morphology, and microbiome in Drosophila nigrosparsa after recovery from antibiotics

Abstract Antibiotics, such as tetracycline, have been frequently used to cure arthropods of Wolbachia endosymbionts. After the symbionts have been removed, the hosts must recover for some generations from the side effects of the antibiotics. However, most studies do not assess the direct and indirect longer‐term effects of antibiotics used to remove Wolbachia , which may question the exact contribution of this endosymbiont to the effects observed. Here, we used the fly Drosophila nigrosparsa treated or not with tetracycline for three generations followed by two generations of recovery to investigate the effects of this antibiotic on the fly locomotion, wing morphology, and the gut microbiome. We found that antibiotic treatment did not affect fly locomotion two generations after being treated with the antibiotic. In addition, gut‐microbiome restoration was tested as a more efficient solution to reduce the potential side effects of tetracycline on the microbiome. There was no significant difference in alpha diversity between gut restoration and other treatments, but the abundance of some bacterial taxa differed significantly between the gut‐restoration treatment and the control. We conclude that in D. nigrosparsa the recovery period of two generations after being treated with the antibiotic is sufficient for locomotion, and suggest a general assessment of direct and indirect effects of antibiotics after a particular recovery time.

Topic: Insect symbiosis and bacterial influences
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Caribbean Sampler (review)

Boozoo Chavis and the Magic Sounds Who Stole My Monkey? Rounder, 1999 CD 21 56, $1 5.OO Boozoo Chavis rocks. A pioneer of the zydeco sound in the 195os, the accordionist remains one of its most influential artists. His latest CD reflects his abiUty to form wide-ranging musical interests into a zydeco flavor rooted in the rural southwest Louisiana where he stiU Uves. Backed by die Magic Sounds, Chavis puts his own take on standbys Uke "AUons a Lafayette," "Baby Please Don't Go," and a CUfton Chenier classic, "LucUle." He also includes many of his own songs, most notably his famous bawdy pieces: "Uncle Bud," and "Deacon Jones," whose subject matter and language have resulted in the "parental advisory" stamped on the cd cover. Longtime underground favorites, these two cuts hint at a deep vein ofAmerican vernacular song that has largely been ignored. Luckily, Chavis has not been similarly overlooked, but, given his infectious and exuberant music, that would be nearly impossible to do. Caribbean Sampler Rounder, 1999 CD I72I, $1 5.OO In 1962 the folklorist Alan Lomax documented Caribbean musical traditions with a series of field recordings much Uke those he had done in the American South. That material was never made commerciaUy available until now. This introductory cd to Rounder's Caribbean Voyage series samples material from Dominica, Grenada, Guadeloupe, Martinique, Carriacou, St. Lucia, St. Barthélémy, AnguiUa, Trinidad, and Nevis. Stressing styles deeply rooted in West and Central Africa and die adaptation of European styles and instruments, the disc also includes a French baUad sung by a white inhabitant of St. Barthélémy and a Hindu prayer from Nevis's East Indian residents. An excellent thirty-seven page booklet puts the digitaUy remastered material in context and provides photos, transcriptions, and a bibUography. Caribbean Sampler is an economical overview of the Caribbean Voyage set and an important document in die history of the African Diaspora. 94 southern cultures, Fall ?999 : GavinJames Campbell ...

Topic: Caribbean history, culture, and politics
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Relationship of Blue and Orange Flower-Color Types in Nemesia strumosa

1. Two flower-color types in Nemesia strumosa are blue-margin and blue. In blue-margin plants possessing the eyebrow gene, there is a band of pale blue color on the inside of the corolla limb around the margins of the lobes of the upper lips, and some blue color is present on the inside of the lower lip at the sides of the tube, frequently extending over the throat. In blue-margin plants homozygous for the allele of eyebrow, the blue color covers practically the entire surface of the inner part of the upper lip. In the blue type both lips are blue on the inner surface. In both types there is little or no orange pigmentation in the lower part of the tube. 2. When combined with the color gene C, blue forms a more bluish-purple color that is often hard to identify, but blue-margin forms a type which is purple on the upper lip and a shade of rose on the lower. This type resembles the bicolor type but can usually be differentiated by the lesser amount of orange in the tube. 3. Blue and blue-margin seem to form a series of multiple alleles with orange and white with orange the top dominant, white dominant to the blue types, blue-margin dominant to blue, and blue recessive to the other three types. The genes are designated, respectively, O, o, obm, and obl. 4. A recessive gene for blue-margin reducer, br, reduces the width of the margin in blue-margin, eyebrow plants. In some places the margin is broken. 5. There is indication of the presence of a dominant gene that acts as an anthocyanin inhibitor.

Topic: Plant and animal studies
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
SIEĆ OSADNICZA I SZLAKI KOMUNIKACYJNE NA ZACHÓD OD POZNAŃSKIEGO PRZEŁOMU WARTY W STARSZYCH FAZACH WCZESNEGO ŚREDNIOWIECZA

In the oldest stages of the early Middle Ages, the settlements located between the Warta and the Obra were concentrated predominantly in a few areas: between the Warta, the Sama and the Samica Stęszewska, in the vicinity of Pniewy and Lwówek, and to the west of Sieraków. The resulting structure, over time supplemented with settlement clusters in Opalenica Plain, formed the basis for a network of gords established in the 9th and the early 10th centuries. The arrangement of hamlets and gords allowed to reconstruct long-range transport routes connecting these regions with south Wielkopolska, Lusatia as well as the north-western Slavic domains.

Topic: Historical and Archaeological Studies
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
2015 Beers criteria medication review in assisted living facilities

ABSTRACT Background and purpose: The elderly population is expected to double by 2050 with falls and hospitalizations due to adverse drug events having a major effect on health and quality of life. With the release of the revised 2015 American Geriatrics Society (AGS) Beers criteria, usage of potentially inappropriate medications (PIMs) should be studied to determine their effect on falls and hospitalizations in frail populations such as those in assisted living facilities. Methods: This quality improvement project used a retrospective chart review on residents from a purposive sample of two assisted living facilities in Northern Virginia. Residents were aged ≥65 and lived at the facility for at least 6 months and were not enrolled in hospice and/or palliative care or living in the dementia unit. The 2015 AGS Beers criteria were used to evaluate the effect of PIMs on falls and hospitalization rates. Conclusions: This project did not find statistical significance between PIMs and falls ( p = .276). A favorable, but not statistically significant trend, was noted between PIMs and hospitalizations ( p = .079). Implications for practice: Understanding the effect of PIMs on falls and hospitalizations could help providers improve prescribing practices for the elderly population who are at the greatest risk for potential adverse effects from polypharmacy.

Topic: Pharmaceutical Practices and Patient Outcomes
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Data from Inhibition of Ubiquitin-Specific Protease 14 Suppresses Cell Proliferation and Synergizes with Chemotherapeutic Agents in Neuroblastoma

&lt;div&gt;Abstract&lt;p&gt;Neuroblastoma is the most common extracranial malignant solid tumor in children, and drug resistance is a major reason for poor outcomes. Elevated proteasome activity plays an important role in neuroblastoma tumor development and resistance to conventional chemotherapy. Ubiquitin-specific protease 14 (USP14), one of three deubiquitinases associated with the regulatory subunit of the proteasome, is emerging as a potential therapeutic target in multiple tumor types. However, the role of USP14 in neuroblastoma is yet to be elucidated. We found that USP14 inhibition in neuroblastoma via knockdown or a specific inhibitor such as b-AP15 suppressed cell proliferation by inducing cell apoptosis. Furthermore, b-AP15 significantly inhibited neuroblastoma tumor growth in NGP and SH-SY5Y xenograft mouse models. For combination treatment, b-AP15 plus conventional chemotherapeutic agents such as doxorubicin or VP-16 resulted in synergistic antitumor effects on neuroblastoma. Our study demonstrates that USP14 is required for cell viability and is a novel therapeutic target in neuroblastoma. Moreover, USP14 inhibition may add value in combination therapy due to its powerful synergistic effects in treating neuroblastoma.&lt;/p&gt;&lt;/div&gt;

Topic: Ubiquitin and proteasome pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Brainstorm

&#x0D; &#x0D; &#x0D; &#x0D; Brainstorming in design typically uses an informal scattered approach. In contrast to this we introduce a focused brainstorm-&#x0D; ing process, adapted from an approach called Motivational Modelling, to guide the process of designing brands. We describe a case study of four real-world briefs, where 79 graphic designers created brandmarks over 12 weeks. The Motivational Modelling approach involves a structured, three- stage process. First, Do/Be/Feel goal generation sessions create word lists. Second, initial brand value diagrams are produced from a subset of the word lists to build brand understanding by entering the words into a custom designed software program. Finally, branded story diagrams are designed to match the brands. We found that the three-stage process was easily adopted by the graphic designers. Creating the diagrams kickstarted the overall branding strategy, which successfully prompted interesting brand values, and clarified project and organizational goals. Clients appreci- ated and implemented the final brainstorming and branding outcomes.&#x0D; &#x0D; &#x0D; &#x0D;

Topic: Creativity in Education and Neuroscience
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Development and validation of machine learning risk prediction models for detection of early-onset colorectal cancer: Data from 30 health systems in the United States.

3613 Background: Incidence of early-onset colorectal cancer (EoCRC) in patients without any family history has been increasing in recent years. Our study leveraged advanced Large Language Models (LLM), like GPT-4, to predict EoCRC in a population comprised of multiple health systems across the United States. There is potential to improve patient care by suggesting early screening for patients who are predicted to be at risk by the model. Methods: We identified a population of 5532 patients aged between 18 and 44 in the Truveta data, which is a collection of 120+ million patient journeys across 30 U.S. health systems. 1376 (24.87%) were diagnosed of CRC based on their ICD and SNOMED-CT codes. Data was split into training (80%) and testing (20%) sets. For the prediction task, we applied GPT-4o and compared with XGBoost, one of the strongest non-generative machine learning models. We used patient demographics (age, gender, race, ethnicity), conditions, and lab results within the last 2 to 7 months prior to CRC diagnosis for model training. The last month before CRC diagnosis was excluded to avoid highly predictive signals. For XGBoost, the demographics were represented as one-hot feature vectors, indicating their presence or absence. Conditions were encoded by their diagnosis frequency within the time frame, while the actual values of the lab results were used as model features. For the LLM model, all patient information was input as plain text. Both conditions and lab results were represented by the names of ICD and LOINC codes in order to capture the clinical context. A Chain-of-Thought prompting strategy, incorporating detailed instructions and CRC-specific knowledge, was employed to guide the LLM. Results: Our test set consisted of 1105 patients in which 279 (25.25%) were diagnosed with CRC. Both XGBoost and GPT-4o achieved comparable results. Despite the uneven distribution of CRC diagnoses in the test samples, the fine-tuned GPT-4o achieved the highest precision (87.43%) and recall (57.35%). This indicates that the model can accurately predict EoCRC in the near future for over half of the patients. Conclusions: This study highlights the potential of using LLM to predict EoCRC in younger population. While the GPT-4o base model contains general medical knowledge, supervised fine-tuning with explicit guideline enhances its predictive capabilities. The high precision of the model performance minimizes the burden of unnecessary screening by identifying patients with relatively high risk. As AI technologies continues to advance, with sufficient governance policy in place, predictive models can be valuable tools for clinicians to suggest early screening and mitigate EoCRC for patients. Model Precision Recall F1 score Accuracy XGBoost 83.77% 57.35% 68.09% 86.43% GPT-4o (base) 68.61% 54.84% 60.69% 82.26% GPT-4o (fine-tuned) 87.43% 57.35% 69.26% 87.15%

Topic: Colorectal Cancer Screening and Detection
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
A New Map Of Arkansas Compiled From The Latest Information by James Callan, Civil Engineer, Washington City. Philadelphia. Published by S. Augustus Mitchell. 1839. Sold By Thomas, Cowperthwait &amp; Co. No. 253 Market Street. Entered ... 1836 by S. Augustus Mitchell ... Pennsylvania. Engraved by J.H. Young.

1st edition 1836, copyright 1836; this is likely the third edition. Scarce, not in Phillips. This map is not listed in any collections; it an early and important map of Arkansas, first published the year (1836) that Arkansas became a state. James Callan compiled the map but little else is known about him. The map shows Land Districts and offices, Military Bounty Lands and Military Townships "unfit for cultivation," Steam Boat Routes, and much other political and physical detail. In the southwest corner of the state the boundary line is west of the final boundary and a line even further west is listed as "Proposed Boundary of Arkansas." See Heaston Catalogue 11 #16 for a copy of the 1837 edition described as "one of the few early Arkansas pocket maps." Full color, folded into beautiful stamped burgundy leather covers 12.5x7.5 with "Mitchell's Map Of Arkansas" in gilt. Prime meridian is Washington D.C. Relief shown by hachures.

Topic: Plant Gene Expression Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
BALANCE IN YOUNG GYMNASTS: AGE-GROUP DIFFERENCES

The aim of this study was to investigate the differences in balance test scores and success on the balance beam of young gymnasts competing at the international level of competition. Forty-eight young female gymnasts divided into two age groups participated in the study (Group 1: n=22, age 9.0 ± 1.1 years, height 136.0 ± 7.6 cm, weight 30.8 ± 4.3 kg; Group 2: n=26, age 12.1 ± 0.6 years, height 146.0 ± 7.0 cm, weight 36.9 ± 6.6 kg). For the assessment of static balance, the participants had to perform three stance variations (double leg, single leg and tandem) on stiff surfaces and the three specific static-balance tests consisted of gymnastics elements on the balance beam (scale, handstand and side handstand). For the assessment of dynamic balance, the participants had performed multidirectional maximal single-leg reaches from a unilateral base of support (Y - balance test) and three specific dynamic-balance tests which consisted of a connection of two gymnastic elements (the 360° turn, jump with a rotation of 180° and the cartwheel). In the static balance tests there is a significant difference only in the one-leg stance (.021) and the specific static balance test (.000). In the dynamic balance tests, there was a significant difference in performing two cartwheels between the two groups (p=.043). These results suggest that the older gymnasts had better results in demanding tests such as the one-leg stance, handstand, and cartwheel on the balance beam. To achieve top results in Women's Artistic Gymnastics it is necessary to achieve good results on the balance beam, and monitor balance ability.

Topic: Sports Performance and Training
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Intracanalicular aneurysm of the anterior inferior cerebellar artery revealed by multi-detector CT angiography.

A 62-year-old woman had sudden-onset headache and posterior neck pain, and a subarachnoid hemorrhage was revealed by unenhanced CT. Both multi-detector CT angiography and digital subtraction angiography were performed and revealed a small intracanalicular aneurysm of the left anterior inferior cerebellar artery. The patient underwent successful retrosigmoid craniectomy and trapping of the aneurysm. This case shows the ability of multi-detector CT angiography to indicate bony landmarks that can alter the surgical approach.

Topic: Intracranial Aneurysms: Treatment and Complications
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
In-Suit Light Exercise (ISLE) Prebreathe Protocol Peer Review Assessment

The performance of extravehicular activity (EVA) by National Aeronautics and Space Administration astronauts involves the risk of decompression sickness. This risk has been mitigated by the use of oxygen "prebreathe" to effectively wash out tissue nitrogen prior to each EVA. Now that the Space Shuttle Program (SSP) is being retired, high-pressure oxygen will become a limited resource. The In-Suit Light Exercise (ISLE) Prebreathe Protocol offers several potential benefits including its potential to save 6 pounds of oxygen per EVA. At the request of the NASA Engineering and Safety Center, the peer review convened on October 14, 2010. The major recommendation of the Review Committee was that the ISLE protocol was acceptable for operational use as a prebreathe option prior to EVA. The appendices to Volume I of the report are contained in this document.

Topic: Cardiovascular and Diving-Related Complications
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Prognostic Significance of EIF4G1 in Patients with Pancreatic Ductal Adenocarcinoma&lt;strong&gt; &lt;/strong&gt;

Background: The advances of genomics have greatly improved the survival rate cancer patients. However, due to genetic heterogeneity, pancreatic ductal adenocarcinoma (PDAC) is still difficult to diagnose early and the survival rate is extremely low. Therefore, we identified biomarkers that predict the prognosis of PDAC patients by using independent cohort data. Methods: To develop a novel prognostic biomarker, we used gene expression and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). In Kaplan-Meier survival curve using median values of genes as cut off, the only statistically significant gene in the three cohorts was EIF4G1. We analyzed prognostic significance of EIF4G1 using the time-dependent area under the curve (AUC) of the Uno's C-index, the AUC value of the receiver operating characteristics (ROC) at 3 years, and multivariate cox analysis. Also, we compare EIF4G1 levels between tumor and matched non-tumor. Results: EIF4G1 is the only prognostic gene patients with PDAC which was selected by Kaplan-Meier survival analysis. Kaplan-Meier survival analysis showed that high expression of EIF4G1 was associated with poor prognosis of PDAC with good discriminative ability in 3 independent cohorts. Risk stratifying ability of EIF4G1 was demonstrated by analyzing C-indices and AUC values. Multivariate cox regression analysis confirmed its prognostic significance. EIF4G1 expression was significantly higher in the PDAC tissues than in the matched normal tissues. Conclusions: Herein, the novel prognostic biomarker EIF4G1 could be used as prognostic maker for PDAC and determining suitable treatment options.

Topic: Pancreatic and Hepatic Oncology Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
A New Route for the Preparation of 10,11-Dihydro-5<i>H</i>-dibenzo[<i>a,d</i>]cycloheptene Using Friedel-Crafts Intramolecular Cyclobenzylation

A convenient preparation of 10,11-dihydro-5H-dibenzo [a,d]-cycloheptene based on a novel Friedel-Crafts intramolecular cyclobenzylation, involving five steps from 1,2-diphenylethane, is described.

Topic: Chemical Synthesis and Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supplementary Figures S1-S8 from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

&lt;p&gt;Figure S1. Expression of 14q32 miRNAs in tumor samples from lung adenocarcinoma patients according to EGFR, KRAS and TP53 mutation status. Figure S2. Methylation analysis of imprinting control regions of the 14q32 cluster in lung adenocarcinoma patients. Figure S3. Association of disease-free survival and N stage in never-smoker lung adenocarcinoma patients. Figure S4. Cell viability of lung adenocarcinoma cells after increasing 14q32 miRNA levels by CRISPR activation technology. Figure S5. Differential expression of genes adjacent to the 14q32 miRNA cluster activated by CRISPR activation technology. Figure S6. Association of genes modulated by 14q32 miRNAs with disease-free survival in lung adenocarcinoma patients. Figure S7. Cell viability of lung adenocarcinoma cells after increasing levels of 14q32 miRNAs by transfection of specific miRNA mimics. Figure S8. Validation of the migratory and invasive effects of miR-323b, miR-487a, and miR-539 on lung adenocarcinoma cells with different genetic background.&lt;/p&gt;

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Fatal COVID-19-Associated Pulmonary Aspergillosis Due to <i>Aspergillus niger</i> Complicated By Pneumothorax: A Case Report.

COVID-19-associated pulmonary aspergillosis (CAPA) carries high mortality. <i>Aspergillus niger</i> is not commonly associated with CAPA. A middle-aged woman presented with cough, fever, and dyspnea for ten days and was subsequently diagnosed with COVID-19. She was mechanically ventilated and given methylprednisolone and broad-spectrum antibiotics. The initial computed tomography pulmonary angiogram (CTPA) was negative for pulmonary embolism, yet the patient's condition continued to worsen. A repeat CT scan of the thorax on day 17 revealed two new cavities. Ensuing tracheal culture was positive for <i>Aspergillus niger</i>, and later complicated with pneumothorax. She was treated with amphotericin B, but her clinical course was complicated by a pneumothorax, for which a chest tube was inserted. Despite all efforts, the patient eventually succumbed. <i>Aspergillus niger</i> infection can have devastating consequences in the setting of severe COVID-19 infection. It raises urgent questions about the need for antifungal prophylaxis. Pneumothorax is a potential complication of CAPA, especially when the cavities are very peripheral.

Topic: Antifungal resistance and susceptibility
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences