jimnoneill/paper-to-field-training huggingface dataset:
Investigating increased hematopoietic stem cell fitness in a novel mouse model

T-cell acute lymphoblastic leukaemia (T-ALL) is a bone marrow (BM) malignancy affecting children and adults. Typically treated with chemotherapy, leukaemia remains a major death cause in people under 20 years old. Understanding molecularly altered pathways in T-ALL may lead to new therapeutic avenues in the future. Ras pathway dysregulation is common in T-ALL. We have shown elevated expression levels of the Ras guanine nucleotide exchange factor RasGRP1 in T-ALL patients, which results in constant production of active Ras (RasGTP). When leukaemia cell lines are exposed to cytokines, RasGTP levels further increase in a RasGRP1-dependent manner. How overexpressed RasGRP1 may impact primary BM cells has remained unknown. We recently published a new <i>RoLoRiG</i> mouse model that allows for pIpC-induced overexpression of RasGRP1 in haematopoietic cells, which can be traced with an ires-EGFP cassette. This novel model revealed that RasGRP1 overexpression bestows a fitness advantage to haematopoietic stem cells (HSCs) over wild-type cells. Intriguingly, this increased fitness only manifests in native Hematopoiesis, and not in BM transplantation (BMT) assays. In this commentary, we summarize key features of our <i>RoLoRiG</i> model, elaborate on BM niche importance, and discuss differences between native Hematopoiesis and BMT in the context of stem cell metabolism.

Topic: Hematopoietic Stem Cell Transplantation
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Stapedius Tendon Reconstruction during Stapedotomy: Technique and Results

During surgery for otosclerosis, it is common for the surgeon to cut the stapedius tendon. Even without reconstruction of the tendon, the results of this kind of surgery are particularly satisfactory. The stapedial reflex is more important for improving intelligibility of speech in the presence of background noise than for protection against hazardous levels of noise. An intact stapedial reflex improves ones ability to follow speech in the presence of background noise. This report will present a technique to reconstruct the stapedius tendon, along with the results obtained when adding this procedure to stapedotomy surgery.

Topic: Ear Surgery and Otitis Media
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
[Heart ventricular cells of neonatal rats in a culture: DNA synthesis, ultrastructure and localization of atrial natriuretic peptide].

We determined the optimal conditions suitable for expanding cardiac cells in vitro for their future use in experimental transplantation into injured myocardium of adult animals. Ventricular cardiac cells were isolated enzymatically from 2-3 day-old rats and cultured at different cell densities within 5-7 days to 4 weeks. Mixed cultures of muscle and non-muscle cells were examined by light autoradiography, electron microscopy, and immunogold method. The best results were obtained at a density of 3 x 10(5) cells/ml in the medium, consisting of 90% DMEM and 10% fetal calf serum, during 5-7 days of cultivation. In such cultures myocytes made 62.5 +/- 7.9%. After a 24 h incubation with 3H-thymidine, 22.0 +/- 2.2% of myocytes were labeled. Muscle cells contact with each other and with non-muscle cells, contain myofibrils, contract and display atrial natriuretic peptide (ANP)-like immunoreactivity.

Topic: Tissue Engineering and Regenerative Medicine
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
OPTIMUM APPLICATION OF MODERN ANTITHROMBOTIC DRUGS AMONG PATIENTS WITH THE ACUTE CORONARY SYNDROME WITH THE RISK OF STRICTURE FORMATION OF CORONARY ARTERIES.

The purpose of the research is to give the effectiveness and safety of ticagrelor in combination with acetylsalicylic acid as preoperative treatment of primary stenting in patients with ACS. We have investigated 42 patients with ACS, 3 of which were diagnosed with cardiogenic shock, age from 38 to 82 years (63 ± 6.5 years). The ACS diagnosis was verified using the results of the ECG, a troponin test and x-ray contrast coronary angiography. The purpose of preoperative antiplatelet treatment prior to primary PCI ticagrelor was administered in the dose of 180 mg and aspirin at a dose of 200 mg. Emergency coronary angiography and primary PCI was performed 15-90 minutes from the time of diagnosis. TIMI III flow in the infarct-related coronary arteries was achieved in all patients. None of the patients the phenomenon of "No-Reflow" has not developed. The appointment of the antiplatelet drug ticagrelor before primary PCI contributes to the achievement of full blood flow restoration in the infarct-related coronary artery, and also reduces the risk of intraoperative and postoperative complications.

Topic: Coronary Interventions and Diagnostics
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
A CASE OF A PRESACRAL EPIDERMOID CYST

症例は36歳,女性.下腹部違和感を主訴にて来院,直腸診で肛門縁から4～5 cmの下部直腸右側に,弾性軟,表面平滑な腫瘤を触知した.骨盤部超音波, CT, MRI検査により前仙骨部嚢胞性腫瘤と診断し,経腹的腫瘤摘出術を施行した.摘出標本は, 7.7×6.8×6.8cm大,表面平滑で弾性軟の単胞性嚢胞であり,内容物は黄白色の粥状物であった.病理組織学的には,嚢胞壁は重層扁平上皮に被われ,皮膚付属器を認めず, epidermoid cystと診断した.仙骨前epidermoid cystの本邦報告例は36例あり,自験例を含めた37例を集計し,検討を加えた.

Topic: Teratomas and Epidermoid Cysts
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Inquérito de suplementação nutricional e experiência no treinamento resistido entre jovens do interior e litoral paulista

To the practitioners of resistance exercise, a better performance is associated with nutritional habits and the help of nutritional supplements. Whatever, this use has been made improperly and without foundation, advised by persons not trained, leading to misuse. To analyze the profile of practitioners in the knowledge of and access to supplements, as well as knowledge about the sport and the need to use additional food resources. A questionnaire will be used to youths aged 15 to 21 consumers of nutritional supplements on the sports, the substance used, why the substance used, who appointed her, which substances have been used, satisfaction with that product, and socioeconomic characteristics of the individual. The data will be correlated by Pearson's correlation coefficient. It is expected that the abuse of supplements is associated with ease by socioeconomic status and experience in the sport for the little progress with the adoption of a routine training exercise in the circumstances only. The major difference compared to the goal of practice, was the motivation for the improvement of physical fitness (Guaruja 21% and Bauru 9.6%), with the intention of increasing muscle mass response occurring closer (Guaruja 22% and Bauru 19.2%) among respondents, and reported more emphasis on the Interior Health (17.3%). The use of supplements is somewhat similar to trends involving body aesthetics and fitness for participation in sports, in the Coast (hypertrophy: 33% body fat reduction, improved endurance and improved performance in sports: 20%), and beauty, fitness and health, the Interior (hypertrophy: 41% increase in strength: 22%, and quality of life: 15%). Interest in the use of supplements is mostly aimed at the improvement of overload training (Guaruja 67% and Bauru 56%) but the sources of information on the use of supplements have become more secure among the respondents of the Interior (gym teacher: 20%, Conferences and Symposia: 12%, and the...

Topic: Muscle metabolism and nutrition
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Assessment of the Prospects of Polish Non-Food Energy Agriculture in the Context of a Renewable Energy Source

This paper describes examples of energy crops that are profitable to burn, and whose cultivation is not complicated or expensive. Rapid growth of biomass, especially the green mass of energy crops, is indicated, which means that, in relation to fossil fuels, energy crops are considered renewable raw materials. An assessment of Polish non-food energy agriculture was conducted in the context of the prospects of a renewable energy source, namely, biomass. Recommendations for crop cultivation, the size of possible yields and the most important parameters of the obtained biomass, which have the greatest impact on the suitability of energy use, are presented. Materials of biological origin for combustion are divided into three groups: wood waste, by-products and plant products for the energy industry. It is indicated that 2 tons (Mg) of dry wood or straw is energetically equivalent to 1 Mg of coal, and 1 m3 of biogas is energetically equivalent to 1 kg of Polish coal. A novelty of this article is the interpretation of obtaining primary energy, including energy from renewable sources, in the European Union and Poland, taking into account the production of wood waste, straw, cereals and energy crops. The mechanism of the impact of the production parameters of energy crops was revealed during the prepared analysis of the prospects of Polish energy agriculture. Additionally, we conducted an analysis of the potential of biomass as a source of energy in the context of: obtaining primary energy, including energy from renewable sources, in the European Union and Poland; the number of biogas plants in Poland; and the area of agricultural land that is potentially useful for the cultivation of energy crops.

Topic: Bioenergy crop production and management
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Motor Vehicle Brake Fluid Based Upon Glycols, Glycol Ethers and the Corresponding Borates

&lt;div class="section abstract"&gt; &lt;div class="htmlview paragraph"&gt;This SAE Standard covers motor vehicle brake fluids of the nonpetroleum type, based upon glycols, glycol ethers, and borates of glycolethers, and appropriate inhibitors, for use in the braking system of any motor vehicle such as a passenger car, truck, bus, or trailer. These fluids are not intended for use under arctic conditions. These fluids are designed for use in braking systems fitted with rubber cups and seals made from styrene-butadiene rubber (SBR), or a terpolymer of ethylene, propylene, and a diene (EPDM).&lt;/div&gt;&lt;/div&gt;

Topic: Adsorption, diffusion, and thermodynamic properties of materials
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Robotics Integration in Manufacturing: Case Study of South Korea

Purpose: Aim of the study was to analyze the robotics integration in manufacturing: case study of South Korea. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: Robotics integration in South Korean manufacturing has revolutionized industry, boosting efficiency, productivity, and global competitiveness. Key sectors like automotive and electronics have seen significant benefits, including reduced labor costs, enhanced product quality, and faster production cycles. This advancement has also spurred innovation in robotics technology, making South Korea a leader in this field globally. Unique Contribution to Theory, Practice and Policy: Diffusion of innovations theory, technology acceptance model (TAM) &amp; network externalities theory may be used to anchor future studies on robotics integration in manufacturing: case study of South Korea. Develop practical guidelines for integrating robotics into diverse manufacturing sectors. South Korea's experience underscores the importance of sector-specific customization and scalability in robot deployment. Establish regulatory frameworks that balance innovation with safety and ethical considerations in robotic manufacturing. South Korea's proactive regulatory policies support industry standards for robot safety and data privacy, fostering a conducive environment for technological innovation.

Topic: Digital Transformation in Industry
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Difficulty of falling asleep and non-high-density lipoprotein cholesterol level among Canadian older adults: a cross-sectional analysis of the Canadian Longitudinal Study for Aging baseline data.

The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males. Further research is needed to confirm these findings.

Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Surface energy balance errors in AGCMs: Implications for ocean‐atmosphere model coupling

The oceanic poleward heat transport ( T O ) implied by an atmospheric General Circulation Model (GCM) can help evaluate a model's readiness for coupling with an ocean GCM. A well known problem is that the sub‐tropical Southern Hemisphere T O implied by many models is equatorward, contrary to most observationally‐based estimates. By correcting the T O of a diversity of models with satellite‐derived observations, an earlier study demonstrated that the dominant T O problems could be explained by model errors in cloud radiative effects. Such errors were argued to be primarily responsible for the erroneous Southern Hemisphere T O . However, systematic evaluation of one model in a later study suggested that the equatorward Southern Hemisphere T O might also be attributable to biases in the ocean surface latent heat flux. In this study we revisit the problem with a more recent suite of simulations, and demonstrate that collectively models have improved, but only slightly. We then use ocean surface fluxes estimates to examine the problem from a surface point of view. Our results clarify that common model errors in the surface latent heat flux can afflict T O as dramatically as errors in cloud radiative effects. To illustrate the relative importance of the two errors, diagnostic tests are introduced that should become increasingly useful as estimates of ocean surface fluxes are improved.

Topic: Climate variability and models
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
CCDC 843147: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Development and validation of cfd model for compost barn with artificial ventilation

Computer simulation can provide reliable information about fluid flow behavior, including ventilation, in animal production systems. The ventilation system is essential for thermal conditioning, as it favors animal comfort and enhance productivity. The objective of this study was to develop and validate a CFD (Computational Fluid Dynamics) model to analyze the ventilation system in a compost barn. A mesh with greater refinement was used near the air inlet and outlet and the floor, that is, in these regions the mesh number of cells was larger, which makes a denser mesh. For the validation, data on air velocity were collected in the barn to compare with the results of the simulation. Dead zones of ventilation were identified in the barn, there was an increase in the average air velocity at the air outlet, and temperatures and air velocity were found below the optimal recommended by the literature. However, the adjusted model showed good fit with the values measured, indicating that is a good tool to predict the behavior of air velocity. In addition, the detection of ventilation dead zones inside the barn demonstrates the need for a supplementary ventilation system.

Topic: Effects of Environmental Stressors on Livestock
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Additional file 2: of Erratum to: Estimation of country-specific and global prevalence of male circumcision

This spreadsheet shows data for number of males using CIA data and estimates of number of circumcised males in all 237 countries and territories in the world, as well as basis for the estimate and MC percentage for each. (XLSX 29 kb)

Topic: Genital Health and Disease
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
The Influence of Dyspnea on Chronic Pain and Psychological Distress Among Adult Patients With Sickle Cell Disease (SCD)

While pain is the hallmark symptom of SCD, respiratory illnesses within this population are common. Respiratory illnesses and their influences on physiological and psychological functioning are not well understood. The purpose of this study was to investigate the effect of dyspnea, a primary respiratory symptom associated with many diseases, on pain and psychological functioning among adult African American patients with SCD. Our results indicated that dyspnea, after controlling for age and gender, did not exert influence on reports of pain

Topic: Hemoglobinopathies and Related Disorders
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Non‐isothermal kinetics of the dehydration process of Na<sub>2</sub>MoO<sub>4·</sub>2H<sub>2</sub>O

Abstract The dehydration process of Na 2 MoO 4 ·2H 2 O and its kinetics have been studied by TG‐DTG. Using Malek method, SB( m,n ) was defined as the kinetic model of the dehydration process. The corresponding kinetic and thermodynamic parameters were obtained.

Topic: Thermal and Kinetic Analysis
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Demonstrating rubber elasticity

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTDemonstrating rubber elasticityF. Rodriguez Cite this: J. Chem. Educ. 1973, 50, 11, 764Publication Date (Print):November 1, 1973Publication History Received3 August 2009Published online1 November 1973Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/ed050p764https://doi.org/10.1021/ed050p764meeting-reportACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Rheology and Fluid Dynamics Studies
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
Scientific prodution about the competencies and skills of the auditor nurse

Introduction: The role of the nurse auditor is to visit the health units and the patients/clients themselves with the objective of evaluating the quality of the facilities, equipment, assistance provided, analyzing the medical records/nursing records; check the compatibility of procedures; guarantee of its functionality, among others. Objective: To analyze the scientific production about the competencies and skills of the nurse auditor. Method: The proposal is a descriptive study, of the narrative review type. Results: Two categories were identified due to content similarity: "Main skills and abilities of the nurse auditor" and "Importance of auditing in nursing". Discussion: Therefore, it can be seen that the nurse auditor is important for the hospital organization, ensuring the best performance of the team as a whole, avoiding as much as possible losses due to errors and waste of the organization's financial resources. Conclusion: From reading the studies that addressed the skills and abilities of the nurse auditor, highlighting the “Main skills and abilities of the nurse auditor” and “Importance of auditing in nursing”.

Topic: Business and Management Studies
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
The reader as subjective entropy: a novel analysis of multimodal readability

Purpose The purpose of this study was to explore the viability of transinformation analysis as a multimodal readability metric. A novel approach was called for, considering that existing and established readability metrics are strictly used to measure linguistic complexity. Yet, the corpus of multimodal literature continues to grow, along with the need to understand how non-linguistic modalities contribute to the complexity of the reading experience. Design/methodology/approach In this exploratory study, think aloud screen recordings of eighth-grade readers of the born-digital novel Inanimate Alice were analyzed for complexity, along with transcripts of post-oral retellings. Pixel-level entropy analysis served as both an objective measure of the document and a subjective measure of the amount of reader information attention. Post-oral retelling entropy was calculated at the unit level of the word, serving as an indication of complexity in recall. Findings Findings confirmed that transinformation analysis is a viable multimodal readability metric. Inanimate Alice is an objectively complex document, creating a subjectively complex reading experience for the participants. Readers largely attended to the linguistic mode of the story, effectively reducing the amount of information they processed. This was also evident in the brevity and below average complexity of their post-oral retellings, which relied on recall of the linguistic mode. There were no significant group differences among the readers. Originality/value This is the first study that uses entropy to analyze multimodal readability.

Topic: Reading and Literacy Development
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences