jimnoneill/paper-to-field-training huggingface dataset:
Effects of Nd3+ on Calcium-Dependent Processes in Isolated Rat Heart Mitochondria and Frog Heart Muscle

The inotropic and chronotropic effects of neodymium ions (Nd3+) on the heart muscle of a frog Rana ridibunda and the influence of Nd3+ on respiration, swelling, and potential (∆Ψmito) of Ca2+-loaded rat heart mitochondria (RHM) were studied. It was found that Nd3+ reduced the amplitude and frequency of spontaneous heart contraction (Fmax); Nd3+ also prevented a short-term increase in Ca2+-induced basal respiration of mitochondria and their swelling in salt media, as well as a decrease of ∆Ψmito on the inner mitochondrial membrane (IMM). At the same time, Nd3+ slightly affected mitochondrial respiration in state 3 or in 2,4-dinitrophenol (DNP)-uncoupled state. These effects of Nd3+ may indicate that Nd3+ inhibits the mitochondrial permeability transition pore (MPTP) opening, which is formed in calcium loaded mitochondria. The data obtained are important for a better understanding of the mechanisms of action of rare earth elements on Ca2+-dependent processes in the myocardium of vertebrates.

Topic: Mitochondrial Function and Pathology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The hidden symbiotic star SU Lyn -- detection of flickering in U band

We report photometric observations of the hidden symbiotic star SU Lyn in the optical bands. In five nights we detect a weak flickering in U band with amplitude of about 0.05 magnitudes. No intranight variations are found in B, V, g' and r' bands. This is one more indication that the secondary component is a white dwarf accreting at low accretion rate. We also searched for intranight variability of a dozen related object (RR Boo, RT Boo, AM Cyg, AG Peg, BF Cyg, NQ Gem, StHa190, V627 Cas, XX Oph, FS Cet and Y Gem) in which no variability above the observational errors is detected.

Topic: Astrophysics and Star Formation Studies
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Steel, Corrosion-Resistant, Bars, Wire, Forgings, Extrusions, and Rings 5.0Mn - 22Cr - 12.5Ni - 2.2Mo - 0.20Cb - 0.30N - 0.20V Solution Heat Treated

&lt;div class="section abstract"&gt; &lt;div class="htmlview paragraph"&gt;This specification covers a corrosion-resistant steel in the form of bars, wire, forgings, extrusions, flash welded rings, and stock for forging, extruding, or flash welded rings.&lt;/div&gt;&lt;/div&gt;

Topic: Metal Alloys Wear and Properties
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Faculty Opinions recommendation of Contemporary Management of Vascular Anomalies of the Head and Neck-Part 1: Vascular Malformations: A Review.

Importance: Vascular anomalies of the head and neck are relatively rare lesions. Management is challenging because of the high likelihood of involvement of functionally critical structures. Multiple modalities of treatment exist for vascular anomalies of the head and neck, including medical therapies, sclerotherapy and embolization procedures, and surgery. This review focuses on the accurate diagnosis and the relative roles of the various therapeutic options.Observations: Vascular anomalies are classified by the International Society for the Study of Vascular Anomalies into 2 major groups: vascular tumors and vascular malformations. Vascular tumors encompass proliferative lesions ranging from infantile and congenital hemangiomas to kaposiform hemangioendothelioma. Alternatively, vascular malformations are embryologic errors in vasculogenesis. This article focuses on the management of vascular malformations. The 3 primary vascular malformation subclassifications are lymphatic, venous, and arteriovenous. The burden of disease, diagnosis, and current management options are discussed in detail for each subtype.Conclusions and Relevance: Most vascular malformations of the head and neck require a multidisciplinary approach. Available medical, interventional radiologic, and surgical interventions are constantly evolving. Optimization of function and cosmesis must be balanced with minimization of treatment-associated morbidity. Otolaryngologists-head and neck surgeons must remain up to date regarding options for diagnosis and management of these lesions. PMID: 33237296

Topic: Vascular Malformations and Hemangiomas
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Multi-population Adaptive Evolutional Algorithm Based on Immune Theory

On the basis of multi-population evolution, immune theory is combined with evolution algorithm, selection, memory, clone, hyper-mutation and concentration control operators are defined, where memory operator is used to memory good gene information of parents and supervise creation of offspring, adaptive hyper-mutation operator enables individuals to confirm the search field according to self choiceness degree and number of evolution generations and concentration control operator is applied for diversity of groups. And then a novel immune algorithm based on multi-population. Emulational results show that IAM has efficient convergent speed and can be converged to the global optimal point. Compared with multi-population genetic algorithm and mind evolutionary computing, its convergent speed and convergent probability are larger

Topic: Artificial Immune Systems Applications
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
A LITURGICAL ALLUSION IN GUY OF WARWICK

Journal Article A LITURGICAL ALLUSION IN GUY OF WARWICK Get access ROGER DALRYMPLE ROGER DALRYMPLE Worcester CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 45, Issue 1, March 1998, Pages 27–28, https://doi.org/10.1093/nq/45-1-27 Published: 01 March 1998

Topic: Medieval Literature and History
Subfield: Classics
Field: Arts and Humanities
Domain: Social Sciences
Tilrettelagt tannhelsetilbud: Erfaringer med tverrfagligbehandling av pasient med sammensatt odontologisk og psykologisk problematikk

English summary TInterdiciplinary dental care: A case study investigating dental and psycological aspects 98-103 The purpose of this case presentation is to make the TOO service known among dentists, as well as pointing out challenges and pitfalls associated with longer courses of treatment involving various groups of professionals and general anaesthesia in hospitals. The presentation places particular emphasis on the part of TOO that practices exposure therapy. This is exemplified by a case concerning a 43-year-old man diagnosed with Asperger's syndrome and odontophobia. While working on this case presentation, we discovered: - In order to give a qualitative good dental treatment for vulnerable patients, extra time and resources are needed as well as an interest in working interdisciplinary. - A lack of litterature concerning post operative follow up after dental treatment performed with general anaesthesia among patients with known psychological difficulties.

Topic: Dental Anxiety and Anesthesia Techniques
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
[Transformation of mouse peritoneal macrophages to foam cells in intraperitoneal injection of low density lipoproteins, cholesterol and its oxidized products].

To investigate the possibility of macrophage transformation to foam cells in vivo, the authors studied 14C-oleate incorporation into cellular cholesterol esters (CES) and the content of free cholesterol (CS) and CES in mouse peritoneal macrophages harvested 24 hours after intraperitoneal injection of native low density lipoproteins (LDL), acetylated LDL (acetyl-LDL), purified CS and CS autooxidated at 60 degrees C for a month. The rate of 14C-oleate incorporation into CES and the content of CES in the macrophages increased in relation to CS levels in the preparations and the nature of the injected agents. Injection of acetyl-LDL (2 mg CS/18 g body weight) and oxidized CS (1 mg/18 g body weight) caused a 10-fold increase of 14C-oleate incorporation into CES and a 60-fold increase of CES concentrations in the macrophages, which was evidence of their transformation to foam cells. The model of obtaining foam cells in vivo may be used in the study of atherogenesis.

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The development of CALL environment on the WWW for teaching academic English

The paper describes a course supported by a hypermedia language-learning environment, called "AcademicEnglish" based on a communicative language teaching approach, for EFL/ESL academicians to improve their communicative competence in academic contexts, and shows the design and implementation of the courseware in this environment. To support our hypotheses in building such an environment, we conducted a questionnaire survey of the difficulties in academic language learning. Moreover, we have explored the research findings of SLA from the educators' and learners' points of view. The focus is to present our approach in communicative-oriented courseware development. Based on our hypotheses, we built an illustrative prototype system, which intends to allow learning goal communication, learning activity negotiation and collaboration between learners.

Topic: Innovative Teaching and Learning Methods
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
A Treatable but Commonly Missed Etiology;An Unusual Presentation of Primary Hyperparathyroidism as Acute on Chronic Recurrent Pancreatitis- A Case Report

Abstract Introduction: Acute pancreatitis is an identified, but uncommon presentation of Primary hyperparathyroidism with prevalence of 3.6%. Hypercalcemia is a rare but known cause of pancreatitis as it leads to premature intra pancreatic activation of protease and destruction of pancreatic tissue leading to pancreatitis. Here we present a case of primary hyperparathyroidism that went undiagnosed for years, and was finally diagnosed after recurrent episodes of pancreatitis of unclear etiology. Case Presentation: A 46-year-old female with history of recurrent pancreatitis presented to the emergency department due to constant epigastric pain for 6 hours associated with nausea and vomiting. Patient reported recurrent episodes of pancreatitis over the past 4 years. Patient was told that etiology of pancreatitis is unclear despite workup. Patient was frustrated that her pancreatitis attacks were usually labeled as alcoholic pancreatitis as she works as a bartender. She strongly states she only drinks alcohol occasionally. She underwent cholecystectomy 2 years ago in attempt to prevent further pancreatitis attacks. Her vital signs were stable. Physical exam was remarkable for epigastric tenderness. CT abdomen and pelvis with contrast showed chronic pancreatitis, pseudocyst and free fluid in the pancreatic bed characteristic of acute pancreatitis. Abdominal US showed post cholecystectomy changes, with no biliary dilatation or stones. Initial labs showed: lipase 2001 U/L, Alcohol level &amp;lt; 10 mmol/L, Calcium 11.5 mg/dl, ionized calcium 4.9 mg/dl, phosphate 2.7 mg/dl, and Triglycerides 52 mg/dl. Subsequently parathyroid hormone was checked and was 116.8 pg/ml. Vitamin D was normal. NM parathyroid scan showed increased tracer activity demonstrating parathyroid adenoma. Patient was given IVF and supportive treatment and her symptoms improved. Endocrinology recommended parathyroidectomy. Patient elected to be discharged and undergoes parathyroidectomy outpatient. Discusion: In this case we emphasize the importance of considering PHPT in acute pancreatitis of unclear etiology especially when Calcium level is elevated. PHPT was missed as a treatable etiology despite mildly elevated calcium level in prior hospitalizations. It is reported that pancreatitis is frequently associated with hypocalcemia with prevalence of 15–88%. Moreover, hypocalcemia is a component of Ranson’s scoring system for severity of pancreatitis. This is explained by precipitation of calcium soaps, hypoalbuminemia and increased calcitonin secondary to glucagon release. PTHT induced pancreatitis management has the same general principles of supportive management. All these patients, once stable, should undergo parathyroidectomy for definitive treatment. Data suggests nearly 100% improvement in pancreatitis symptoms and prevention of recurrent pancreatitis episodes after the cure of PHPT.

Topic: Pancreatitis Pathology and Treatment
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Brownfields, Crime, and Tax Increment Financing

When the determinants of property value include a central city—a location in which private businesses are often reluctant to invest—property values are no longer a simple function of land and demand features but are also influenced by health and welfare issues such as neighborhood crime and environmental contamination. To maintain economic vitality, central cities require not only the presence of market forces and the provision of public amenities that commonly increase the value of property but also the implementation and effectiveness of public policies directed at stimulating property valuation to combat the negative influences of these unique features of the urban environment. This article examines tax increment financing in relation to the health and welfare issues of crime and brownfields. The authors empirically show that the public policy of tax increment financing can effectively increase districtwide property valuation to counteract the negating effects of crime and brownfields.

Topic: Housing Market and Economics
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
4 Shuttle Orbiter Production Change Impact Assessment Process ‐ A Collaborative Team Effort

Abstract The present Space Shuttle program is one in transition ‐ both from the government agency and the contractor level. NASA is restructuring the management of the Space Shuttle Program by turning over the reins of the day‐to‐day operations to a prime contractor, United Space Alliance (USA) ‐ a joint venture partnership with Boeing and Lockheed Martin as major subcontractors. This move is intended to save millions of dollars in costs by eliminating duplicate resources, streamlining operations, and reducing nonessential program requirements. Most separate shuttle related contracts have been consolidated into one Shuttle Program. While this consolidation effort is taking place, NASA, USA, Boeing are working closely together to provide the American public a Space Shuttle Program that continues to be technically viable, safe, and now more cost effective. Central to organizational consolidation is the way people think and do their work. Changes have been made emphasizing working together as teams and improving the processes they use. A critical process, that was changed, is the Orbiter modifications and upgrades change process. This process covers all changes to the Orbiter hardware, which fix flight to flight anomalies (modifications) as well as make upgrades, which increase safety, meet upcoming manifests, improve supportability and reduce costs. This paper deals specifically with process improvements made to the change control process methodology and implementation procedures (known as the change impact assessment process) by NASA, USA and Boeing to be more proactive and cost effective.

Topic: Technology Assessment and Management
Subfield: Safety, Risk, Reliability and Quality
Field: Engineering
Domain: Physical Sciences
Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells

Miltirone (1) is a diterpene quinone extracted from a well-known Chinese traditional herb (Salvia miltiorrhiza). We investigated the cytotoxic effects of miltirone toward sensitive and multidrug-resistant acute lymphoblastic leukemia cell lines. Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp)-overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that miltirone induced G2/M arrest and apoptosis. Furthermore, miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation of caspases and poly ADP-ribose polymerase (PARP). Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with miltirone-induced G2/M arrest. Moreover, miltirone decreased cell adherence to fibronectin. Molecular docking revealed that miltirone bound to the ATP-binding site of IKK-β. In conclusion, miltirone was collateral sensitive in multidrug-resistant P-gp-overexpressing cells, induced G2/M arrest, and triggered apoptosis via ROS-generated breakdown of MMP and DNA damage. Therefore, miltirone may be a promising candidate for cancer chemotherapy.

Topic: Acute Myeloid Leukemia Research
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Blended e-Learning: Survey of On-line Student Assessment

The e-studium project (https://estudium.unipg.it/) has experimented the introduction of blended e-learning course support in heterogeneous courses of University of Perugia. The assessment process in the e-studium project consists of two main stages: first students apply for an exam through an additional module purposely developed for e-studium, and integrated in the basic platform; then online exam tests are delivered to the candidate which interacts with a quiz management module. In this paper we report and analyze data collected in the two-year period 2007-2008, and referring to four Computer Science course exams. Data about exam enrollment, test assessment, number of attempts and time needed for test completion have been analyzed. A comparative time-related analysis has been carried out for the four course exams, relationships between teaching and learning activities performed over the platform have been investigated, and used to evaluate the effectiveness of the proposed approach within an academic setting.

Topic: Artificial Intelligence in Education
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
<i>In vitro</i> metabolism of neostigmine and pyridostigmine

Journal Article In vitro metabolism of neostigmine and pyridostigmine Get access P A Burdfield, P A Burdfield Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK Search for other works by this author on: Oxford Academic Google Scholar T N Calvey, T N Calvey Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK Search for other works by this author on: Oxford Academic Google Scholar J B Roberts J B Roberts Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3BX, UK Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 25, Issue 5, May 1973, Pages 428–429, https://doi.org/10.1111/j.2042-7158.1973.tb10045.x Published: 12 April 2011 Article history Received: 11 February 1973 Published: 12 April 2011

Topic: Fungal Biology and Applications
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
A Facilitated Survey Instrument Captures Significantly More Anesthesia Events Than Does Traditional Voluntary Event Reporting

Survey of Anesthesiology: August 2008 - Volume 52 - Issue 4 - p 204-205 doi: 10.1097/01.SA.0000307949.10717.46

Topic: Cardiac, Anesthesia and Surgical Outcomes
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Wound healing in pinealectomized rats

Wound healing is a complex repairing process. Melatonin which is secreted in darkness at night is a molecule that has both antioxidant and systemic effects. In our study, by making pinealectomy, we aimed to investigate how chronically impaired basal secretion of melatonin affected wound healing process. In this study 14 Sprague-Dawley male rats were used. These rats were separated into two groups, and pinealectomy was performed to one of these groups. Six excisional skin wounds were opened on dorsal part of all rats under anesthesia 15 days after pinealectomy. Wound tissues were excised under anesthesia after the measurement of wound area eight days later. Measurements of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and hydroxyproline (OH-proline) were made in these tissues. Excision of the pineal body caused increase in MDA levels in the wound tissues (p

Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Sr-Nd isotopic heterogeneities in high-grade metamorphic conditions: an example from the anatectic complex of Toledo (Spain)

Preliminary data on the study of Sr-Nd isotopes in metapelitic, restite-rich granitoids and anatectic leucogranites from the Anatectic Complex of Toledo (Centro-lberian Hercynian zone), reveal the absence of isotopic homogenization as it would be expected in a high grade metamorphic area in which important volumes of anatectic leucogranites are generated. Several factors as the short-lived metamorphic climax, the highly anhydrous conditions, and the source heterogeneity seem to be crucial for isotopic homogenization to be not achieved

Topic: Geological and Geochemical Analysis
Subfield: Geophysics
Field: Earth and Planetary Sciences
Domain: Physical Sciences
A refresher on the basics

This chapter will provide a “refresher” on some of the background topics necessary for the following chapters. It is assumed that the reader is already relatively familiar with the basics of characterizing noise and distortion, with the principles behind the classic data converter architectures, and with some rudimentary idea of calibration. These are, in fact, topics that are much more extensively covered in other books and publications [5, 34, 52, 53, 54]. The intent here is to recall them and to build upon them by expanding the topic a bit more than is usually done in analog design textbooks, to prepare the ground for the more advanced topics covered in the following chapters.

Topic: Analog and Mixed-Signal Circuit Design
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Effect of Pituitary Adrenocorticotrophic Hormone (ACTH) on Experimental Poliomyelitis and Equine Encephalomyelitis

Journal Article Effect of Pituitary Adrenocorticotrophic Hormone (ACTH) on Experimental Poliomyelitis and Equine Encephalomyelitis Get access Albert Milzer Albert Milzer Department of Bacteriology and Virology, Medical Research Institute of Michael Reese Hospital, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 88, Issue 1, January 1951, Pages 54–55, https://doi.org/10.1093/infdis/88.1.54 Published: 01 January 1951 Article history Received: 08 July 1950 Published: 01 January 1951

Topic: Leptospirosis research and findings
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences