Hyperglycemia and Hypertriglyceridemia Among Persons with Coronary Heart Disease

Article1 July 1967Hyperglycemia and Hypertriglyceridemia Among Persons with Coronary Heart DiseaseLEON D. OSTRANDER JR., M.D., F.A.C.P., BEVERLY J. NEFF, PH.D., WALTER D. BLOCK, PH.D., THOMAS FRANCIS JR., M.D., SC.D., FREDERICK H. EPSTEIN, M.D.LEON D. OSTRANDER JR., M.D., F.A.C.P., BEVERLY J. NEFF, PH.D., WALTER D. BLOCK, PH.D., THOMAS FRANCIS JR., M.D., SC.D., FREDERICK H. EPSTEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-34 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoronary heart disease has been associated with a number of physiologic abnormalities, of which hypertension and hypercholesterolemia have been most clearly defined as risk factors.Regardless of the mechanism of atheroma formation high serum levels of cholesterol or other lipid fractions would be expected to accelerate atherogenesis. This relationship is supported by a great deal of epidemiologic evidence (1-3).High levels of blood glucose are also found with significant frequency among persons with atherosclerosis (4-6), but it is difficult to rationalize a direct relationship between an abnormality in carbohydrate metabolism and the development of atheroma, which consist largely of lipid...References1. STAMLERLINDBERGBERKSONSHAFFERMILLERPOINDEXTER JHADMAWA: Prevalence and incidence of coronary heart disease in strata of the labor force of a Chicago industrial corporation. J. Chronic Dis. 11: 405, 1960. CrossrefMedlineGoogle Scholar2. KANNELDAWBERKAGANREVOTSKIESTOKES WBTRANJ: Factors of risk in the development of coronary heart disease—six year follow-up experience. The Framingham study. Ann. Intern. Med. 55: 33, 1961. LinkGoogle Scholar3. PAULLEPPERPHELANDUPERTUISMACMILLANMCKEANPARK OMHWHGWAHH: A longitudinal study of coronary heart disease. Circulation 28: 20, 1963. CrossrefMedlineGoogle Scholar4. 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KANELONGCOPEPAVLATOSGRODSKY JPCFCGM: Studies of carbohydrate metabolism in idiopathic hypertriglyceridemia. Metabolism 14: 471, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the University of Michigan Medical School, Ann Arbor, Mich.This study was supported by program project grant HE-6378 to the Cardiovascular Research Center, University of Michigan, from the National Heart Institute, National Institutes of Health, Bethesda, Md.Dr. Epstein was supported by Public Health Service research career program award HE-K6-6748, the National Heart Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Leon D. Ostrander, Jr., M.D., Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich. 48104. 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Evaluation of paper electrophoresis techniqueSOME EFFECTS OF ORAL CONTRACEPTIVES ON CARBOHYDRATE METABOLISMInterrelationships of Hyperinsulinism and Hypertriglyceridemia in Young Patients with Coronary Heart DiseaseAlterations of Factors Predisposing to Coronary Heart DiseaseLEON D. OSTRANDER JR., M.D., F.A.C.P.Current Metabolic-Genetic Interrelationship in Human Atherosclerosis With Therapeutic ConsiderationsPETER T. KUO, M.D., F.A.C.P.PREDNISONE-GLUCOSE TOLERANCE AND SERUM LIPIDS IN SURVIVORS OF MYOCARDIAL INFARCTIONSPECIAL ARTICLE 1 July 1967Volume 67, Issue 1Page: 34-41KeywordsAtheromasAtherosclerosisCoronary heart diseaseHyperglycemiaHypertensionLipidsLongitudinal studiesMedical risk factorsPrevention, policy, and public healthResearch laboratories Issue Published: 1 July 1967 PDF DownloadLoading ...

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences