jimnoneill/paper-to-field-training huggingface dataset:
A pilot presurgical study evaluating anti-PD-L1 durvalumab (durva) plus anti-CTLA-4 tremelimumab (treme) in patients (pts) with high-risk muscle-invasive bladder carcinoma (MIBC) who are ineligible for cisplatin-based neoadjuvant chemotherapy (NAC).

4551 Background: In MIBC pts, especially in those with high risk features including lymphovascular invasion, hydronephrosis, T3b disease, or variant histology, cisplatin-based NAC followed by cystectomy improves overall survival as compared with cystectomy alone. However, it is estimated that over 50% of pts with MIBC are ineligible for cisplatin-containing therapy. Therefore, we propose this pre-surgical trial with durva + treme for this population of pts. Methods: This is a single-arm, pre-surgical clinical trial with durva + treme in pts with localized, high-risk MIBC (cT2-T4a) who are ineligible for cisplatin-based NAC due to decreased renal function, neuropathy, hearing loss, or heart failure; or refuse cisplatin-based NAC (NCT02812420). Each patient receives durva (1500 mg) plus treme (75 mg) on weeks 1 and 5. Pts then undergo surgery at week 9-11. Pre- and post-treatment blood and tumor samples are collected for correlative biological analyses. Results: Twenty eight of 35 pts have been enrolled on this trial. Twenty-one pts have completed cystectomy as of 11/16/19. Of these 21 pts, 9 (43%) had pathologically complete response (pCR) and two (10%) had pathologic T1N0 (pT1) disease (≤pT1N0 rate = 52%). Fourteen of 21 (67%) had down-staging of disease. Of note, 10 of these 21 pts had 3-D mass (T3) on exam under anesthesia or clinical T4a disease; 5 of these 10 pts (50%) had pCR and one (10%) had pT1 disease (≤pT1N0 rate = 60%). Only 5 of 28 (17%) pts developed grade 3 immune related toxicity including hepatitis and amylase/lipase elevation, and two (7%) resulted in surgery delay for &gt; 30 days. Immune profiling with CyTOF analysis of baseline peripheral blood indicates that pts with pCR have significantly lower frequency of a Th2 subset as compared to pts with up-staging of disease. In addition, gene expression profiling analysis of baseline tumor tissues demonstrates a significantly less immunosuppressive microenvironment in pts with pCR as compared to pts with up-staging of disease. Conclusions: Our data indicate that durva plus treme is an effective and safe neoadjuvant therapy for pts with MIBC ineligible for cisplatin-based therapy. Therefore, neoadjuvant therapy with durva + treme and a number of potential biomarkers warrant testing in a larger phase 3 trial. Clinical trial information: NCT 02812420.

Topic: Bladder and Urothelial Cancer Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
New Philosophy for New Media

June 01 2006 New Philosophy for New Media Eugene Thacker Eugene Thacker School of Literature, Communication, and Culture, Georgia Institute of Technology, Atlanta, GA 30332-0165, U.S.A. E-mail: eugene.thacker@lcc.gatech.edu Search for other works by this author on: This Site Google Scholar Author and Article Information Eugene Thacker School of Literature, Communication, and Culture, Georgia Institute of Technology, Atlanta, GA 30332-0165, U.S.A. E-mail: eugene.thacker@lcc.gatech.edu Online ISSN: 1530-9282 Print ISSN: 0024-094X © 2006 Massachusetts Institute of Technology2006 Leonardo (2006) 39 (3): 266–267. https://doi.org/10.1162/leon.2006.39.3.266 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Eugene Thacker; New Philosophy for New Media. Leonardo 2006; 39 (3): 266–267. doi: https://doi.org/10.1162/leon.2006.39.3.266 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsLeonardo Search Advanced Search This content is only available as a PDF. © 2006 Massachusetts Institute of Technology2006 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Embodied and Extended Cognition
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
DILTIAZEM HCL MICROCAPSULES USING ETHYL CELLULOSE ETHER DERIVATIVE POLYMER AS RELEASE RETARDING AGENT: IN-VITRO CHAPTER

This study presents sustained releasemicroencapsulation of Diltiazem HCL.&#x0D; Its in-vitro dissolution study in phosphate buffer pH 7.4 as dissolution medium and in vivo behaviour in animal subjects. The microcapsules were prepared using polymers Ethocel 7P and Ethocel 7FP at two different drug to polymer (D: P) ratios i.e. 1:5 and 1:10 and the effect of concentration was observed on drug release behaviour. The prepared microcapsules were evaluated for different physical characteristics i.e. Bulk density, Tap density, Compressibility index, Hausner’s ratio and Angle of repose. Characterization of the developed microcapsules was carried out using Differential Scanning Calorimetery and Fourier Transform Infrared Spectroscopy while Scanning Electron Microscopy was performed to observe the morphology of the microcapsules. Model dependent and in dependent approaches were used to find out the drug transport mechanism and to compare the drug release profiles with standard formulation respectively.&#x0D; All the formulations show anomalous, non-Fickian diffusion mechanism and the data was best fitted in Korsmeyer’sPeppas equation.&#x0D; While carrying out in vivo studies, simple and rapid HPLC methods were developed which revealed optimum serum concentration (Cmax) levels for the developed microcapsules predicting least chances of side or adverse effects.

Topic: Drug Solubulity and Delivery Systems
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Perioperative Management of a Patient with Secreting Paraganglioma Undergoing Cesarean Section

Paraganglioma is a catecholamine-secreting tumor (CST) in extra-adrenal autonomic ganglia and a rare cause of hypertension during pregnancy. If not properly treated, it can lead to disastrous outcomes for both the mother and fetus. This report describes the successful anesthetic management of a paraganglioma diagnosed during pregnancy. A pregnant woman, with 32 weeks of gestational age, presented with severe paroxysmal hypertension, refractory to methyldopa and nifedipine at maximum dosages, headache, sweating, and palpitations. Diagnostic work-up was positive for elevated serum and urinary normetanephrines, and magnetic resonance showed a solid nodule above the hilum of the right kidney, suggestive of paraganglioma. Optimal alpha-blockade was achieved with doxazosin, and given the advanced gestational age, tumor resection was postponed until after delivery. Cesarean delivery was scheduled at 34 weeks, under combined spinal-epidural anesthesia and continuous blood pressure monitoring. Antihypertensive drugs were prepared for immediate administration as needed. Intraoperative and postoperative periods went uneventfully for both the mother and newborn, both under intensive care observation for 24 h.

Topic: Adrenal and Paraganglionic Tumors
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Relationships among Emotional Reactions, Impression Evaluations, and Preference Towards Video Pictures

In the research on emotion, films have been used widely as a means for eliciting emotions in a laboratory because they affect psychological states of human beings. The studies by Philippot (1993), Gross & Levenson (1995) and Noguchi (2005) showed that specific emotion states, i.e., amusement, anger, contentment, disgust, fear, happiness, neutral, sadness and surprise, should be reliably elicited by films. In the media society we are living, the use of films as an effective representation for communicating information among ourselves has been increasing. As the previous studies showed, films should elicit emotions, and therefore the films used in the media society should affect the emotional nature of the media society. In order to establish a sound media society, it is required for those who produce films to understand appropriately the psychological states of the people who watch them. The purpose of this study was to develop producers' media literacy by the knowledge how specific films used in the media society should elicit specific emotional states of the viewers. We investigated psychological states of viewers in terms of their Kansei reaction, which is, in this experiment, the ability to induce the preference evaluation, i.e., like or dislike, when watching the films. We used four films associated with different types of information having the same playback time. Forty-nine participants carried out preference evaluations after watching the four films. We measured the Kansei reactions of the participants using 16 emotions proposed by Gross & Levenson (1995) and impression evaluations for 14 adjective pairs proposed by Gwasaki (2002). The result showed the way how the emotions and the impressions affected “like” and “dislike”. In particular, it was found that the emotion of “tension” is the key of the preference evaluation.

Topic: Color perception and design
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
THE FORMATION OF PHYSICAL EDUCATION AMONG ADOLESCENTS AND ITS IMPORTANCE

Annotation: In this article examines the main trends in the development of <br> physical education of secondary school students, reveals the factors of the development <br> of physical education of the younger generation, takes into account the individual and <br> psychological characteristics of students.

Topic: Physical Education and Training Studies
Subfield: Physical Therapy, Sports Therapy and Rehabilitation
Field: Health Professions
Domain: Health Sciences
A Framework for Guaranteed Maximum Price and Contingency Development for Integrated Delivery of Transportation Projects

This paper discusses the components of a guaranteed maximum price (GMP) and proposes a framework for the development of GMPs as contract payment provisions for construction manager-at-risk (CMR) and design-build (DB) contracts for transportation projects. The framework is the synthesis of a comprehensive literature review, a content analysis of CMR and DB solicitation documents and contracts, and case study project output from twelve projects in nine states worth $3.1 billion. The research also discusses the development of three common types of contingencies that are often utilized in projects with GMPs. The study concludes that owners should specify the structure of the GMP and its components to enhance clarity and understanding of the GMP's composition. It recommends that this structure be included in the CMR and DB solicitation documents so that pricing proposals can be formulated in a manner that is consistent with the contract payment provisions that will be useful to practitioners that need to implement GMP-based contracts.

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Gate first high-k/metal gate stacks with zero SiO x interface achieving EOT=0.59nm for 16nm application

Gate first 0.59 nm EOT HfOx/metal gate stacks for 16 nm node application are demonstrated for the first time. By controlling O during HfOx deposition, ldquozerordquo low-k SiOx interface (ZIL) forms despite a 1020degC activation anneal. This 0.59 nm EOT is a 30% improvement over a state of the art 32 nm HK/MG technology. We compare and demonstrate for the first time the improved scalability of ZIL HfOx vs. exotic higher-k. Transistors made with ZIL HfOx show good interfaces (SS=70-80 mV/dec, Nit = 5 times 1010/cm2) and performance (10% Ion-Ioff boost vs. EOT = 0.95 nm), despite mobility loss. Factors contributing to mobility loss in ZIL HfOx are discussed.

Topic: Semiconductor materials and devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
LHD ICH-ICE2 #148878.1

High-frequency Magnetic Probe to measure high-frequency waves, e.g. waves excited by ICRF antennas or waves excited by high-energy particles. Probe head is one-turn loop with Faraday shield. Two loops are paired with different turn direction. Frequency range: approximately 10 kHz - 1 GHz. Loop size: 15 cm x 15 cm.

Topic: Ectopic Pregnancy Diagnosis and Management
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Ecosystem modelling for ecosystem-based management of bivalve aquaculture sites in data‑poor environments

Although models of carrying capacity have been around for some time, their use in aquaculture management has been limited. This is partially due to the cost involved in generating and testing the models. However, the use of more generic and flexible models could facilitate the implementation of modelling in management. We have built a generic core for coupling biogeochemical and hydrodynamic models using Simile (www.simulistics.com), a visual simulation environment software that is well-suited to accommodate fully spatial models. Specifically, Simile integrates PEST (model-independent parameter estimation, Watermark Numerical Computing, www.pesthomepage.org), an optimization tool that uses the Gauss-Marquardt-Levenberg algorithm and can be used to estimate the value of a parameter, or set of parameters, in order to minimize the discrepancies between the model results and a dataset chosen by the user. The other critical aspect of modelling exercises is the large amount of data necessary to set up, tune and groundtruth the ecosystem model. However, ecoinformatics and improvements in remote sensing procedures have facilitated acquisition of these datasets, even in data-poor environments. In this paper we describe the required datasets and stages of model development necessary to build a biogeochemical model that can be used as a decision-making tool for bivalve aquaculture management in data-poor environments.

Topic: Marine Bivalve and Aquaculture Studies
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
Subretinal delivery of AAV5-mediated human <i>Pde6b</i> gene ameliorates the disease phenotype in a rat model of retinitis pigmentosa.

Our results demonstrate that AAV5-<i>Pde6b</i> may be a potential therapeutic gene candidate for RP caused by <i>Pde6b</i> mutations.

Topic: Retinal and Optic Conditions
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Relief of Intraocular Pressure by Applying Pressure on the Posterior Scleral Wound

Tarpon Springs, Florida This section is an open forum and consists of the opinions and personal commentary of the writers. The views expressed care exclusively those of the writers and do not purport to reflect those of ASCRS or the journal.

Topic: Traumatic Ocular and Foreign Body Injuries
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Mirror Reflections: The Influence of Body Perception on Obesity Bias among University Students

<title>Abstract</title> <bold>Background: </bold>This study investigates the relationship between body perception and obesity bias among university students. Understanding these dynamics is crucial for developing interventions that promote positive body image and reduce weight stigma. <bold>Methods: </bold>A descriptive cross-sectional study was conducted with 334 university students (237 females, 97 males) aged 18-24 from Tekirdağ Dormitory at Namık Kemal University. Participants' sociodemographic and anthropometric details were collected, and assessments were made using the Body Cathexis Scale (BCS) and the Obesity Bias Scale (GAMS-27). Statistical analyses included Chi-Square, Kolmogorov-Smirnov, Mann-Whitney U, t-test, Kruskall-Wallis H, One Way ANOVA, correlation analysis, and regression analysis. <bold>Results: </bold>The study found that 81.1% of students had a high perception of their body image. Male students had higher body image and obesity bias scores than female students. Among the participants, 6.3% exhibited no bias, 43.1% were prone to bias, and 50.6% were biased. Obesity bias did not significantly differ among underweight, normal-weight, and overweight students. Individuals with low body perception exhibited higher obesity bias (65.1%) compared to those with high body perception (47.2%). A negative correlation was found between body perception and obesity bias, suggesting that lower body image scores are associated with higher obesity bias. <bold>Conclusions: </bold>Improving body image is essential for reducing obesity bias among university students. Addressing societal ideals and fears related to weight gain can foster positive body perceptions and mitigate bias. Interventions promoting body acceptance and challenging stereotypes are necessary to create a more inclusive environment.

Topic: Obesity and Health Practices
Subfield: Pharmacy
Field: Health Professions
Domain: Health Sciences
Scattered X-ray intensities from fluoroscopy units

We refer to the protection afforded by multileaf Pb aprons on fluoroscopy units and would like to offer our own illustrative example of the importance of such measures in shielding against scattered radiation. Our concern lies with an incident that occurred in a hospital and which involves a fluoroscopy unit (a Siemens Gigantos with a 100 kW multipulse generator capable of delivering 1000 mA and 150 kVp) that was operated in the absence of its protective Pb aprons. Figure 1 shows the image of a gastrointestinal tract (using Curix Agfa Gevaert X-ray film and a CaWO4 normal-speed screen combination) and a superimposed forearm (not that of the patient).

Topic: Radiation Dose and Imaging
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
IMPACT OF THE EXISTENCE OF THE MANDALIKA CIRCUIT ON THE COMMUNITY ECONOMY IN KUTA VILLAGE, CENTRAL LOMBOK

This research is motivated by the existence of the Mandalika Circuit which has brought changes to the people of Kuta Village, Pujut District, Central Lombok Regency. This research uses a descriptive-analytic research method that analyzes the data found with data obtained in the field. The method used to obtain data is by using observation, interviews and documentation methods. As well as data analysis using the data reduction stage, data presentation or data display stage and verification or conclusion drawing stage. The results of this research show that the impact of the existence of the Mandalika Circuit on the income of the people of Kuta Village, Pujut District, Central Lombok Regency has had a positive impact on the economy of the people of Kuta Village. Especially for business actors in Kuta Village, they really feel the change in their business income compared to their income before the Mandalika Circuit existed.

Topic: SMEs Development and Digital Marketing
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
mRNA-based COVID-19 Vaccines Appear to not Increase Immune Events in Cancer Patients Receiving Immune Checkpoint Inhibitors

In parallel to the increased vaccination rates of cancer patients, the real-world data will show the long-term safety of mRNA-based COVID-19 vaccines in cancer patients treated with ICIs."

Topic: SARS-CoV-2 and COVID-19 Research
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Reform and practice of the electronic circuit experiment teaching mode for the purpose of strengthening the electronic system design ability

An analog circuit laboratory course was reformed at Southeast University with the goal of strengthening students' electronic system design ability. Compared to the traditional Chinese laboratory course, this course design included the innovative aspects of combining individual circuits with systems, theory with practice, simulation with implementation, basic with advanced requirements, individual work with teamwork, and included a more comprehensive assessment. This course also aimed to develop the innovative capacity and engineering practice ability of students. Honors students who took this laboratory course believed that it stimulated their interest and motivation to learn and helped them appreciate the spirit of teamwork.

Topic: Experimental Learning in Engineering
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
There still a long way to go for cancer registration in China.

Cancer is currently a global issue. Every year, millions of people die of cancer. Cancer is now the top killer of population health in China because of the pollution of the environment, water and air is getting worse day by day, also the food additives and pesticides are overused widespread. In recent years, the cancer incidence and mortality increased rapidly in China. So, it is very important to collect information about cancer cases, cancer deaths, cancer follow-up and survival data at national level for cancer surveillance, intervention evaluation, and policy or decision-making (1).

Topic: Nutrition, Genetics, and Disease
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Organizational Form, Parental Involvement, and Quality of Care in Child Day Care Centers

This research compares cooperative child day care centers to for-profit and independent nonprofit centers in terms of parental involvement in operations (such as fundraising and classroom participation), parental involvement in governance (specifically, serving on the board and attending the annual meeting), and quality of care. It also tests whether parent control of the board is associated with quality. Findings show that cooperative centers feature greater parental involvement in operational aspects, including fundraising and care of the center or grounds compared to for-profits and independent nonprofits. Cooperatives are also more likely to have parents on their boards and feature boards with parent majorities compared to independent nonprofits, although more than half of these nonprofit centers also have parent-controlled boards. Results also show that while the cooperative form, tested as a distinct organizational type, is not a predictor of quality, parent control of the board is a positive predictor of this outcome.

Topic: Parental Involvement in Education
Subfield: Education
Field: Social Sciences
Domain: Social Sciences