jimnoneill/paper-to-field-training huggingface dataset:
CCDC 207525: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: X-ray Diffraction in Crystallography
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Effect of statins on the serum soluble form of receptor for advanced glycation end-products and its association with coronary atherosclerosis in patients with angina pectoris

Advanced glycation end-products (AGEs) and their receptor (RAGE) play an important role in the pathogenesis of diabetic vascular complications. Recently, soluble form of RAGE (sRAGE) has been identified in mice and humans. Statins have been reported to increase serum sRAGE levels. However, whether modulation of circulating sRAGE levels has a beneficial effect on the progression of atherosclerosis is unknown. We reviewed 91 patients who had undergone percutaneous coronary intervention for angina pectoris. Coronary atherosclerosis in non-culprit lesions in the target vessel was evaluated, using virtual histology intravascular ultrasound, and serum levels of AGEs and sRAGE were measured, at baseline and after 8 months of statin therapy. Statins had no effects on serum AGEs levels; however, serum levels of sRAGE were significantly higher at the 8-month follow-up. A significant decrease in external elastic membrane (EEM) volume (− 1.6%, p = 0.005) was observed, whereas a decrease in plaque volume did not reach statistical significance (− 1.9%, p = 0.16). Univariate regression analyses showed that the percentage changes in serum sRAGE were negatively correlated with those in EEM volume (r = − 0.198, p = 0.06) and plaque volume (r = − 0.247, p = 0.02). Multivariate regression analysis showed that an increase in serum sRAGE level was an independent predictor of atheroma regression after statin therapy (β = − 0.290, p = 0.006). Statin therapy increased serum sRAGE levels, and this increase was associated with negative vessel remodeling and atheroma regression in the coronary artery.

Topic: Advanced Glycation End Products research
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
EFFECTS OF 8-WEEK ELECTRICAL MUSCLE STIMULATION ON THE MUSCLE CONTRACTILE PROPERTIES IN ADOLESCENT GIRLS

The study aimed to determine the effect of 8-week unilateral electrical muscle stimulation (EMS) training of leg muscles: vastus lateralis, vastus medialis and biceps femoris with the same number of muscle contractions in comparison to controls. Contractile properties were monitored by measuring the maximal voluntary isometric contraction (MVC) and the rate of force development in first 50 ms (RFD50) of knee extensors and flexors and tensiomyography of stimulated muscles. In addition, we also investigated the retained effect after 8 weeks without EMS training. Nineteen healthy young female athletes aged 15 to 18 years (average 16.4 ± .9 years) were randomly divided in a control group (CG; N=8) and experimental group (EG; N=11). CG performed maximal unilateral voluntary contractions while the EG performed also EMS training of the same leg by stimulating both vasti muscles and biceps femoris. There were no changes in CG after 8-weeks of maximal unilateral voluntary training; however, EG improved MVC in knee extensors (12.6%; P =.085) and RFD50 (142.1%; P =.049) where RFD50 retained increased also 8 weeks after EMS training (73%; P =.090). Tensiomyography revealed decreased amplitude (13.2%; P=.011) only in EG, representing higher muscle tone after 8-weeks of EMS in comparison to CG. Our findings indicate that EMS training has a positive effect on muscle contractile properties in young female athletes even after comparing to matched controls by the number of contractions.

Topic: Muscle activation and electromyography studies
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
[Diabetes mellitus and periodontal diseases].

Opinions on the interdependence between diabetes mellitus and oral periodontal disease are controversial. Experimental and clinical investigations carried out so far have not brought unique results. General objective of our research is to investigate on the strictly defined group of subjects aged 35-44 with diabetes mellitus type I the influence of metabolic control HbA1C on changes of periodontium and other organs. According to duration of diabetes mellitus the patients are divided into subdecade and postdecade groups. This group consists of 56 patients out of which 33 patients are with subdecade and 23 with postdecade insulin-dependent diabetes mellitus. In this group periodontal pocket depths, gingival index, number of extracted teeth and the volume of nonstimulated saliva are measured in comparison with a control group. The incidence of oral diseases and complications in other organs of insulin-dependent patients in subdecade and postdecade period are also examined and recorded. Periodontal diabetic disease is verified by pathohistological findings. Values of HbA1C in either subdecade or postdecade group with diabetes mellitus are above normal values. Values of periodontal pocket depths as well as the values of gingival index are substantially greater at insulin-dependent diabetes mellitus patients compared to the control group.

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Modulaton of gene expression in human aortic smooth muscle cells by Porphyromonas gingivalis : a possible association between periodontitis and atherosclerosis

Porphyromonas gingivalis is a gram-negative, rod-shaped, and anaerobic bacterium that is involved in the pathogenesis of periodontitis. P. gingivalis produces a variety of virulence factors includi ...

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
The Scattering of 9.6 MeV Protons by Mg

Absolute differential cross sections are given for the elastic and inelastic scattering of 9.62 MeV protons by Mg for an angular range of 25°-145° (laboratory coordinates). For scattering by the 1.37 MeV level of 24Mg, the angular distribution is also given for an incident energy of 8.86 MeV. A marked difference in angular distribution at the two energies is noted.

Topic: Nuclear physics research studies
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
A Historical Context for Understanding “An Eye Roll Test for Hypnotizability” by Herbert Spiegel, M.D.

Herb Spiegel was known for many professional and scientific achievements. He may be best remembered for his discovery of the Eye Roll Sign (ERS) and its relation to innate trance capacity and the parallel creation and development of the Hypnotic Induction Profile (HIP). The present paper provides a historical context for understanding Herb's 1972 publication of "An Eye Roll Test for Hypnotizability" which originally appeared in the American Journal of Clinical Hypnosis 38 years ago and is reprinted in this journal issue.

Topic: Pain Management and Placebo Effect
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Degenerate electron gas effects in the modulation spectroscopy of pseudomorphic Al0.32Ga0.68As/In0.15Ga0.85As/GaAs high electron mobility transistor structures

The effects of a degenerate two-dimensional electron gas on the interband optical excitations, occurring in the active channel of Al0.32Ga0.68As/In0.15Ga0.85As/GaAs high electron mobility transistor structures, were investigated by using phototransmittance spectroscopy. The ground state transition at room temperature exhibited a characteristic steplike line shape, which was considered to be an effect of the screening of excitons by the degenerate electron gas. A line shape fitting by using a first derivative of the absorption coefficient with respect to the electron sheet concentration ns, allowed an estimation of the latter quantity by phototransmittance. An observed temperature-sensitive excitonlike signal, associated with the second electron subband was attributed to the modulation of the many-body correlation-enhanced excitonic absorption, known as the Fermi-edge singularity.

Topic: Semiconductor Quantum Structures and Devices
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Stakeholder Management: A Universal Strategic Health Services Management Approach to Unlock a Profitable Return on Investment

There have been sustained global policy and fiscal pressures for businesses, including health care services to demonstrate unique customer-oriented entrepreneurship capabilities in terms of marketing and innovativeness, influenced by the recent global financial crisis, leading to business closures, budgetary shortfalls, and constant operational challenges for survival. For several health care managers, this entails effectively managing the increasing influence of active and powerful stakeholders to achieve a competitive advantage in terms of productive and allocative efficiency over customer-driven results and innovativeness. A focus on value addition by itself is a precursor of effective stakeholder management, clinician leadership model, and a decentralized activity based management, which integrates customer values from basic and expected services to desired and unexpected services as well as combining product quality and high quality customer services needed to usher a competitive advantage to organizations through cost leadership or product differentiation. However, a stakeholder management tool that is universally applicable across all health care business entities is still work in progress. This paper debated upon relevant previous literature on stakeholder management as a central feature for customerdriven business practices, for implementation in form of a universal stakeholder management tool, in order to advance sound entrepreneurship capabilities that support dynamic high quality customer care-driven health care and innovation.

Topic: Organizational Leadership and Management Strategies
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
A CI Supporting Model for Software Outsourcing

With the increasing development of software outsourcing (SO) in many countries, the competition between different software outsourcing vendees is very fierce. This paper provides a nontechnical analysis of ways that competitive intelligence (CI) system can be used by SO receivers to acquire information of the competitors, market and industry in order to gain perpetual competitive advantages. A conceptual model is designed with an insightful structure of both intangible and tangible measures. Detailed measures are enunciated in 3 parts: environmental analysis, competitor analysis and SO contractees analysis. Finally, the significance and creativity of this research are concluded.

Topic: Outsourcing and Supply Chain Management
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
EFFECT OF DURATION OF STEAM-BOILED CASTOR BEAN CAKE ON PERFORMANCE OF BROILER CHICKENS

The effect of duration of steam-boiled castor bean cake on the performance of broiler chickens was investigated. Castor bean cake was steam boiled for 0, 30, 40, 50 and 60 minutes respectively for treatments one to five and included at 15% in their diets. Apart from the control diet which had no inclusion of castor bean cake, birds fed diets with castor bean cake steam boiled for 30 minutes showed the best results in average daily weight gain, feed intake, feed to gain ratio and feed cost per kilogram weight gain. The declined performance with increasing durations of steam boiled castor bean cake was attributed to possible compromise of the protein quality. The study therefore concluded that castor bean cake can supplement other protein sources in broiler diets at 15% inclusion level if it is steam boiled for 30 minutes. Further steaming of castor bean cake beyond 30 minutes is not productive as it may alter the protein quality.

Topic: Food Science and Nutritional Studies
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Development of a Wireless Application for Remote Control of Space Test Facilities

A wireless application based on a PDA and a mobile phone has been developed at AEROSPAZIO Tecnologie to allow remote control of space test facilities and increase the staff mobility. The application developed in house has been compared with the available software over different networks. The test activities and results are described

Topic: Energy Efficient Wireless Sensor Networks
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
How Disclosure Requirements Affect Investors and Sponsors:Evidence from Real Estate Crowdfunding

The development of real estate crowdfunding in the past few years is attributed mostly to the passage of the JOBS Act. Although the SEC set disclosure requirements for crowdfunding, we notice there are still different levels of disclosure among platforms. In this thesis, we examine whether the different disclosure policies set by platforms affect projects’ proposed return and sponsors’ behavior. Due to the two-way causality relationship between disclosure requirements and proposed return, we use the simultaneous regression model to estimate. The empirical results show sponsors who launch projects on a platform with lower disclosure standard raise projects proposed returns as an attractive means. Sponsors who were supposed to prefer a less stringent regulation are surprisingly willing to disclose more information. This study is the first information asymmetry study on debt-based crowdfunding and provide implications for practice.

Topic: FinTech, Crowdfunding, Digital Finance
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Near focus NBI endoscopy plus acetic acid for optical polyp characterization in the colorectum - A proof of principle study

<b>Background and study aim:</b> Optical polyp characterization (OPC) in the colorectum is an upcoming challenge for endoscopists. Narrow band imanging (NBI) has been proposed to be helpful for OPC. However, data from clinical studies have shown that quality of OPC differs markedly between endoscopists. The aim of this study was to test the value of a combined NBI plus acetic acid (<i>NBI + AA</i>) approach for OPC in the colorectum. <b>Patients and methods:</b> This was a prospective, single-arm study at a tertiary referral center in Germany. The study was designed as a proof of principle study. Initially polyps were characterized using High-definition white light (<i>HDWL</i>) only. Additionally, the same polyps were investigated using <i>NBI + AA</i> (1.5% solution) in order to predict polyp pathology in a real time setting. The near focus function was used for both <i>HDWL</i> and <i>NBI + AA</i> assessment. The primary endpoint was accuracy of colorectal polyp prediction when using <i>NBI + AA</i>. <b>Results:</b> A total of 63 polyps were detected in 55 patients. <i>NBI + AA</i> based accuracy of real-time predictions was 85.5% compared to 80.6% using <i>HDWL</i> (<i>p</i> = .450). Accuracy was 90.2% in the high confidence setting for both <i>NBI + AA</i> and <i>HDWL</i> predictions. A higher share of polyps were assessed with high confidence when using <i>NBI + AA</i> compared to <i>HDWL</i> (<i>p</i> = .006). The use of <i>NBI + AA</i> led to a better identification of polyp margins (<i>p</i> < .001) compared to <i>HDWL</i>. <b>Conclusions:</b> The use of acetic acid led to a high level of accuracy and confidence in the prediction of polyp histology. These data justify further investigation in a randomized controlled study.

Topic: Colorectal Cancer Screening and Detection
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
番茄microtubule-associated RING E3 ligase 1之功能分析

我們先前發現一功能未知之番茄C3H2C3 type RING E3 ubiquitin ligase，將之命名為SlREL1 (Solanum lycopersicum RING E3 Ligase 1)。SlREL1可能參與番茄抗青枯病品系H7996之防禦反應，其表現在花與熟果較高，且其蛋白產物可能坐落在細胞骨架上。本研究旨在進一步探討SlREL1與其同源基因之蛋白質特性及功能。序列比對結果發現番茄有另一REL基因(SlREL2)；此兩蛋白質在其C端除了保守的RING domain外，也同時有一序列保守但功能未知的DAR1 domain (domain associated with RING 1)。SlREL1被預測具有一進核訊號與許多可能可被激酶進行磷酸化的區域。微管螢光標定物與微管聚合抑制劑試驗確認SlREL1坐落在微管網路上，且其胺基酸片段1-170為必要區段。In vitro self-ubiquitination assay證實SlREL1具有E3 ligase活性，且RING和DAR1 domains在其活性上具關鍵角色。SlREL1-RNAi轉殖番茄之青枯病抗性提高，且其花粉萌發情形較為遲緩，而過量表現SlREL1的轉基因菸草其青枯病病程發展則略為提早。根據短暫基因靜默與過量表現試驗結果初步推測SlREL1在乾旱、鹽害及氧化逆境反應也許不具關鍵功能。此外，阿拉伯芥有三個REL基因(AtREL1、AtREL2及AtREL3)，且其蛋白質產物在C端亦具有保守的RING domain與DAR1 domain；阿拉伯芥微陣列資料顯示AtREL1/2之轉錄表現在花粉中最高且會受許多病害與非生物性逆境因子調控，而AtREL3表現則較不受這些因子影響。此外，AtREL1也在細胞中呈現絲狀分布，且亦具有E3 ligase活性。這些結果指出SlREL1為一坐落在微管上之E3 ligase，其RING與DAR1 domain皆參與其酵素活性之維持，且阿拉伯芥AtREL1亦具有與SlREL1類似的蛋白質特性。SlREL1可能參與花粉萌發與青枯病反應。

Topic: Ubiquitin and proteasome pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The characterisation of circulating biomarkers and body composition before and after cardiac resynchronisation therapy in patients with chronic heart failure and their role in predicting response

Heart failure is a common condition which carries a high mortality and morbidity. Despite improved medical therapy the outcomes for heart failure with a reduced ejection fraction remain poor. Cardiac resynchronisation therapy has revolutioned the treatment of patients with heart failure with a reduced ejection fraction and dyssynchrony, refactory to medical therapy, improving morbidity and mortality. Unfortunately a significant minority fail to respond to this expensive therapy, which is challenging for both the patient and society.&#13;\n&#13;\nOver the last 15 years research has focused on attempting to predict non-response. Evidence suggests wider QRS duration and bundle branch morphology on the resting electrocardiograph are the most important predictors of response and outcome following implantation of a cardiac resynchronisation device. However, the non-response rate remains unchanged despite extensive research.&#13;\n&#13;\nMolecular systems have been shown to alter with the development and progression of heart failure. Many of these systems are now utilised in the diagnosis and prognostication of heart failure. Cardiac resynchronisation therapy device implantation has been shown to alter these dysregulated molecular systems. Specific circulating biomarkers reflect these respective systems. Cardiac extracellular matrix is a dynamic support structure that has altered turnover in heart failure and is affected when cardiac resynchronisation devices are implanted. Micro ribonucleic acids have been observed recently to be important in molecular systems regulation and dysregulation has been observed in heart failure. Furthermore altered expression following cardiac resynchronisation therapy device implantation has been reported. The evidence suggests circulating biomarkers for these systems have the potential to predict response. Our prospective study examined specific biomarkers that the literature suggests has the potential to predict response, but the evidence is currently inconclusive. Moreover we utilised other important patient variables known to be predictors from the wider literature and our own retrospective cohort analysis of response to test alongside specific circulating biomarkers. We offer an informed pilot study to test important circulating biomarkers for their clinical ultility to predict heart failure patient’s ability to respond to cardiac resynchronisation therapy.

Topic: Cardiac pacing and defibrillation studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Multimodal and Multi-Output Deep Learning Architectures for the Automatic Assessment of Voice Quality Using the GRB Scale

&lt;p&gt;This paper addresses the automatic assessment of voice quality according to the GRB scale, based on the use of a variety of deep learning architectures for prediction purposes. The proposed architectures are multimodal, because they employ multiples sources of information; and also multi-output, because they simultaneously predict all the traits of the GRB scale. A feature engineering approach is followed, based on the use of deep neural networks and a set of well-established features such as MFCC, perturbation and complexity characteristics. Likewise, a representation learning is considered, using convolutional neural networks feed on modulation spectra extracted from voices. Finally, diverse loss functions are also investigated, including two surrogate ordinal classification, a conventional weighed categorical cross-entropy, and a mean square error function. Experiments are carried out in a dataset containing registers of the sustained phonation of three vowels. The best deep learning architecture provides a relative performance improvement of 6.25% for G, 14.1% for R and 18.1% for B, in comparison with recently published results using the same dataset.&lt;/p&gt;

Topic: Speech Recognition and Synthesis
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Development of the Steel Rod Technique for the Assessment of Aeration in Urban Soils

Diagnosis of poor performance in urban trees requires means of evaluating soil aeration. A technique using 60 cm long steel rods inserted into the ground has been developed into an effective and practical means of assessing the vertical and spatial distribution of soil aeration in urban soils; even those covered by hard surfaces. A laboratory study verified the interpretation of the four types of corrosion found on steel rods with respect to soil aeration, although the presence of uncorroded metal could not be clearly related to suitability for root growth. A field study indicated that the best numerical reflections of soil aeration are the total presence of corrosion types indicative of inhospitable soil conditions, and the contrast between inhospitable conditions in the top 30 cm and the bottom 30 cm of the rod.

Topic: Tree Root and Stability Studies
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
In the shadow of the wrinkle: experimental models

Summary Research on aging has run for decades, and knowledge on the biologic process of skin chronological and photoaging is still increasing thanks to read across results generated between human, animal, and in vitro studies. However, wrinkles should not be considered to result only from the aging process. There are few reports on specific wrinkle histological features compared to the surrounding skin, and there is thus a need in really wrinkling skin animal and in vitro models. UV‐irradiated Hr mouse is a good model because it develops wrinkles. Nevertheless, as mouse skin is somehow different from human skin, the innovative model of wrinkling human skin xenograft on SCID mice seems to be really promising. Concerning in vitro and ex vivo models, although there have been considerable advances in reconstructing realistic aged skins, there is still a lack of in vitro wrinkling skin model, and unfortunately, this gap will probably be difficult to fill.

Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences