jimnoneill/paper-to-field-training huggingface dataset:
Functional Precision in Pancreatic Cancer: Redefining Biomarkers with Patient-Derived Organoids

Pancreatic cancer remains a lethal disease despite advances in surgery and systemic treatment in the last two decades, underscoring the urgent need to better understand its biological underpinnings. Despite remarkable advances in the molecular characterization of pancreatic ductal adenocarcinoma (PDAC), clinically actionable biomarkers remain scarce, and current treatment remains empiric. Transcriptomic subtypes such as “classical” and “basal-like” offer some prognostic value, but their ability to guide real-time treatment decisions is limited. In this review, we explore the limitations of current biomarker strategies, in particular subtype-based classifications, and argue for a functional reframing of biomarker development in PDAC, centered on patient-derived organoids (PDOs). We explore four key domains in which PDOs deepen our understanding of therapeutic response and resistance, namely, drug response phenotyping, modeling chemoresistance, incorporating tumor microenvironmental complexity through co-culture systems, and more functional profiling through proteomic and metabolomic approaches. Together, these applications move PDOs beyond static avatars of the tumor to dynamic platforms capable of capturing clinically relevant biology. As functional precision medicine gains traction, PDOs may offer a path to more tailored, responsive treatment strategies in a cancer where new options are urgently needed.

Topic: Pancreatic and Hepatic Oncology Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
&lt;title&gt;User interface optimization in a radiography display console&lt;/title&gt;

Radiologist productivity has been a major factor limiting the acceptance of soft copy image displays. This situation is particularly acute in projection radiography. Three principal factors contribute to radiologist productivity: image quality, the user interface and system response time. These factors are not completely separable. In particular, it is difficult to optimize the user interface when system response times are a major limiting factor. A newly developed high speed multi-screen display system has enabled further refinement of the user interface into the subsecond regime. The present work focuses on optimizing control of zoom, roam and gray scale windowing. We describe the clinical optimization protocol and the user interface evolved therefrom. We also discuss the subjective impressions of the radiologists involved.

Topic: Digital Radiography and Breast Imaging
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
How Web 2.0 Shapes Patient Knowledge Sharing

Web 2.0 has totally changed the health communication world. In particular, it has reconfigured peer exchanges about health. These exchanges are important because they allow knowledge sharing and construction between patients, in particular chronic patients. Although their importance is well established, this field of study brings together a variety of theories not uniformly shared or understood. It is not clear how patients use Web for knowledge processes: what kind of knowledge processes happen in Web 2.0 between patients? How does Web 2.0 sustain or impede these processes? The aim of this research is to map virtual exchanges about diabetes in Italy by developing a systematic exploration of Web using the main search engines (Google, Yahoo) and analyzing the site that hosts posts and exchanges about diabetes. According to a psychosocial perspective, findings highlight the main features of online knowledge processes among patients.

Topic: Social Media in Health Education
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
The Role of Civic Engagement for Men’s Health and Well Being in Norway—A Contribution to Public Health

Objectives: Using the example of older men volunteering on teams that restore historic ships, this article examines the effects of volunteering on the well-being of older adults. We consider particularly how volunteering impacts levels of social engagement and explore how the men’s reminiscences as they bond with their fellows …

Topic: Tourism, Volunteerism, and Development
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
Pengaruh Corporate Social Responsibility dan Intellectual Capital Pada Kinerja Keuangan

The aim of this research is to know the influence of corporate social responsibility and intellectual capital on financial performance. Theories used are stakeholder, legitimacy, and resource-based theory. This research conducted on trading companies listed on the Indonesia Stock Exchange in 2015-2017. The samples taken were 26 companies, by non-probability sampling method with purposive sampling technique. Data collected through non-participant observation. The analysis techniques used are descriptive statistical analysis, classical assumptions, and multiple linear analysis. Based on the analysis found that corporate social responsibility has no effect on financial performance. This indicates that the high and low disclosure of CSR will not affect the financial performance of the trade sector. The second hypothesis states that intellectual capital has a positive effect on financial performance. This indicates that the higher the intellectual capital, the higher the financial performance of the company. Combination of intellectual capital can enhance competitive advantage for companies.&#x0D; Keywords: Financial performance, corporate social responsibility, intellectual capital

Topic: Corporate Governance and Financial Management
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Partial Bone Necrosis Following Sagittal Split Ramus Osteotomy: Report of a Complicated Orthognathic Jaw Surgery

Study Design Case Report. Objective To present a case of a previous complicated mandibular orthognathic surgery that aimed to setback the mandible in a female cleft lip and palate (CLP) patient, which led to bone necrosis on one side with subsequent severe mandibular deviation and facial asymmetry. We additionally reviewed the previous reports of similar complications, the pathophysiology and the factors that could lead to this dreadful result. Method A 27-year-old female patient presented with a severe dentofacial deformity secondary to a complicated bilateral sagittal split ramus osteotomy performed five years earlier, which resulted in aseptic bone necrosis on the right side. The patient had marked mandibular deviation, chin and midface retrusion and a pronounced occlusal discrepancy. Imaging demonstrated a bony defect at the right mandibular angle with a superiorly displaced proximal segment. Deviation of the mandible was corrected first by performing vertical ramus subsigmoid osteotomy (RSO) on the left side. The right bone defect was then reconstructed with a reconstruction plate and bone grafting. Maxillary and chin advancement was performed at a second stage. Results On follow-up, the patient shows a significant improvement in facial esthetics and mandibular symmetry and is currently under orthodontic management to enhance the occlusal relationship. Conclusion Bone necrosis is a rare but dreaded problem in orthognathic surgery. Minimizing the musculo-periosteal dissection and competent execution of the bone osteotomy is substantially effective in reducing the risk of bone ischemia and necrosis.

Topic: Cleft Lip and Palate Research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Metabolic Products of Cholesterol in Bile and Feces of Rat. Steroids and Bile Acids

Summary1. After administration of cholesterol-4-C14 to rats the main excretory products in the bile are cholic and chenode-soxycholic acid present as taurine conjugates. 2. The labelled material present in feces has been fractionated. It has been found that most of the conjugate has been split. No unchanged cholic acid seems to be left in the feces. A series of different labelled products have been separated some at least of which contain ketonic groups.

Topic: Aldose Reductase and Taurine
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
ECHR decision to refuse to waive the immunity of a person under article 1 of the protocol no. 6: Individual interpretations of the essence and consequences

In present-day Ukraine, there is no unanimous answer to the question of the essence and consequences of the ECHR decision to refuse to waive immunity under Article 1 of the Protocol No. 6 either in the national criminal procedural legislation, or in the theory of criminal procedure, or among judges, investigators, prosecutors. Therefore, the purpose of the present paper is to try to attempt to formulate individual approaches to address this issue. The relevance of the subject under study is conditioned upon its theoretical and practical components. The former is that there this area is heavily understudied, and judicial practice, among other things, requires a certain scientific basis to formulate individual positions in their unity. The dilemma proposed in the title of this study was also addressed by members of the Scientific Advisory Board of the Supreme Court, who were approached by judges of the Grand Chamber for scientific opinions, emphasising the urgency and necessity of feedback from practitioners. To formulate the individual approaches serving the purpose of this study, the authors employed such general and special research methods as dialectical, induction and deduction, Aristotelian, system-structural, sampling method, comparison, and legal forecasting. Notwithstanding the fact that the ECHR decision to refuse to waive the immunity stipulated in Article 1 of the Protocol No. 6, adopted by its plenary session in accordance with Article 4 of the Protocol No. 6 to the General Agreement on Privileges and Immunities of the Council of Europe, is “procedural”, it was proven that the Grand Chamber of the Supreme Court has the authority to conduct proceedings on the application of such a person to review the judgment precisely in exceptional circumstances. It is emphasised that the ECHR decision should be considered as one that does not aim at the final assessment of criminal proceedings, so it cannot be equated with the decision of an international judicial institution, which would state Ukraine's violation of international obligations in court and the order of its execution will differ. The authors also address the fact that the consequences of the ECHR decision to refuse to waive the immunity stipulated in Article 1 of the Protocol No. 6 are critical. After all, such a decision of the European Court of Human Rights is the “bell” for Ukraine, which, among other things, may hint at the probability that the Court will identify the facts of human rights violations

Topic: Ukrainian Cultural and Linguistic Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Allenyl and Alkynyl Selenols and Selenocyanates. Synthesis,\nSpectroscopic Characterization, and Quantum Chemical Study

Allenyl and alkynyl selenols and selenocyanates with gradually increasing distance between the selenium\natom and the unsaturated group have been synthesized and studied by photoelectron spectroscopy and\nquantum chemical calculations. In the triple-bonded derivatives &lt;b&gt;1&lt;/b&gt;, &lt;b&gt;2&lt;/b&gt;,&lt;b&gt; 5&lt;/b&gt;, and &lt;b&gt;6&lt;/b&gt; (1-alkynylselenium\nderivatives), an enhanced conjugative interaction was observed, which results in a considerable (0.12−0.13 Å) Se−C bond shortening. In the propargyl &lt;b&gt;3&lt;/b&gt; and &lt;b&gt;7&lt;/b&gt; and homoallenyl derivatives &lt;b&gt;10&lt;/b&gt; and &lt;b&gt;13&lt;/b&gt; a slight\nbut readily well observable hyperconjugation effect could be found. In the case of allenyl selenium\nderivatives &lt;b&gt;9&lt;/b&gt; and &lt;b&gt;12&lt;/b&gt; both effects are in operation, which result in a moderate Se−C bond shortening.\nWith the previously reported study of alkenyl selenium derivatives, the type and extent of the interaction\nbetween the SeH or SeCN group and an unsaturated moiety (alkenyl, allenyl, or alkynyl substituent) are\nnow completely clarified.

Topic: Genetic and Environmental Crop Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Automating the determination of low-temperature fracture resistance curves of normal and rubberized asphalt concrete in single-edge notched beam tests using convolutional neural networks

As materials undergo large-scale yielding or exhibit large sizes of fracture process zone in the crack tip region, multi-parameter fracture concepts should be employed to describe the complex crack-tip stress-strain fields. Fracture resistance curves (R-curves) are an established tool in characterizing the entire fracture process of such materials. However, for complex materials such as bituminous mixtures, the development of these curves is subject to experimental and computational intricacies. In this research, a framework is developed to automate the construction of R-curves for normal and rubberized asphalt concrete (AC) mixtures. AC mixtures are produced using PG58–22 and PG58–28 binders. Limestone and siliceous aggregates are used, and three binder contents are considered for the mixtures. Single-edge notched beam (SE(B)) fracture testing is conducted on AC beams with two different notch patterns. A convolutional neural network (CNN) model is developed and trained over 1260 test images with varying temperatures, notch geometries, and setups. The CNN model was used to detect the growing crack on the beam surface and each crack-detected image was sent to an image processing framework to measure the crack length. Crack extension increments were calculated and synchronized with test time and magnitude of load, load-line displacement, and cumulative fracture energy, and the R-curve could be constructed. A training accuracy of 0.91 was obtained for the model and a loss of below 0.10 as a result of a hyperparameter tuning indicating reliable classifications by the CNN architecture. The R-curves showed desirable agreement for control mixtures at temperatures of 0 °C and −15 °C. As the mixtures are rubberized, the R-curves showed favorable agreement in the crack blunting phase, transition zone, as well as the unstable propagation phase at −20 °C. Cohesive energy magnitudes were compared for the two methods with a Pearson coefficient of 0.81 while fracture rate and fracture energy magnitudes showed favorably close magnitudes with coefficients of 0.89 and 0.98 respectively.

Topic: Asphalt Pavement Performance Evaluation
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
The Mode of Overwintering ofTrichogramma nubilaleErtle and Davis12

Laboratory experiments were conducted using a variety of photoperiod and temperature conditions to determine the mode of overwintering exhibited by Trichogramma nubilale Ertle and Davis. The results of these tests show that T. nubilale probably overwinters by hibernation in host eggs. In addition, it was determined that overwintering success is optimal for those parasites which developed to the pupal stage In eggs of the European corn borer, Ostrinia nubilalis (Hübner).

Topic: Insect-Plant Interactions and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Effective employee job crafting in the workplace

Purpose Superior firm performance and a favorable impact on employee well-being are some key benefits attainable when workers engage in job crafting. High levels of intrinsic motivation in the employees involved increases the overall effectiveness of such activities. Team context factors can positively affect motivation levels, with knowledge sharing and mutual trust particularly important. Design/methodology/approach This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings Superior firm performance and a favorable impact on employee well-being are some key benefits attainable when workers engage in job crafting. High levels of intrinsic motivation in the employees involved increases the overall effectiveness of such activities. Team context factors can positively affect motivation levels, with knowledge sharing and mutual trust particularly important. Originality/value The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

Topic: Job Satisfaction and Organizational Behavior
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Impact on financial productivity: A study of training effects on consulting services

Abstract An evaluation study was conducted to assess the return on investment of training. Investment consisted of the development and delivery costs associated with increasing the competence of consultants in a tax specialty area. A three‐phase study was implemented to (1) determine pretraining trends, (2) evaluate the training event, and (3) follow the activities of students after training. While data were obtained from multiple sources throughout the study, key information in determining financial impact was obtained from accounting data bases. Return was defined as the amount of time required for the training to result in a payback equal to the original investment. After the revenues that could be attributed to training were determined, results indicated that the training had a substantive positive financial impact. The findings are discussed from the standpoint of the appropriate theoretical paradigm for this type of evaluation. Specifically, the authors point to the need to avoid issues of cause and effect and to utilize an evidentiary paradigm in drawing conclusions.

Topic: Financial Reporting and Valuation Research
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Mandibular Intraosseous Lipoma: A Case Report and Review of Literature

Case ReportLipoma is a common benign mesenchymal tumor of soft-tissue.In the oral cavity lipomas represent 0.5 to 5% of benign tumors, however, central intraosseous forms are exceptional, mainly at the mandibular bone.Most of intraosseous lipomas are asymptomatic and discovered on x-ray.Symptoms of intraosseous lipoma vary depending on the location and size of the tumor.Radiographically, the lesion generally appears as a well-circumscribed radiolucent image.In fact, the diagnosis of intraosseous lipoma of the mandible can be problematic due to its rarity and clinical and radiological similarity to many other radiolucent lesions, therefore, histopathological examination is always essential.The treatment of choice for intraosseous lipomas is the surgical enucleation of the lesion.The article presents a case report of intraosseous lipoma of mandible in a 58-year old male.Diagnosis, differential diagnosis and treatment of this benign tumor are discussed based on a review of the current literature.

Topic: Tumors and Oncological Cases
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Human leukocyte cathepsin G and elastase specifically suppress thrombin- induced prostacyclin production in human endothelial cells

Polymorphonuclear leukocytes (PMN) when activated release products that can potentially injure endothelial cells or alter endothelial function. Exposure of cultured human umbilical vein endothelial cells to cathepsin G and elastase isolated from human PMN at concentrations reached in vivo (100 ng/mL to 10 micrograms/mL) selectively inhibited thrombin-induced prostacyclin production and the thrombin-induced rise in cytosolic free calcium ([Ca++]i) concentration. These proteases also blocked thrombin-induced release of arachidonic acid from prelabeled endothelial cells (EC). In contrast, induction of prostacyclin (PGI2) production by arachidonate, histamine, or the calcium ionophore A23187 was not altered by treatment of EC with these proteases. The effects of the proteases were concentration-dependent, were blocked by serum or serum protease inhibitors, and were reversed when the endothelial cells were further cultured for 24 hours in the absence of the proteases. Elastase, but not cathepsin G, also produced detachment of endothelial cells. Thus, the major leukocyte proteases selectively suppress thrombin-induced prostacyclin production by human vascular endothelial cells and may alter the hemostatic balance at sites of PMN activation.

Topic: Antiplatelet Therapy and Cardiovascular Diseases
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Treatment outcome of patients with mandibular symphyseal fractures treated with titanium plate and screw fixation

Objective: To describe the clinical and radiographic characteristics of patients with mandibular fractures in the chin region treated with titanium plate and screw fixation at Viet Tiep Hospital in 2023. Subjects and Methods: A cross-sectional descriptive study was conducted on patients diagnosed with mandibular fractures in the chin region who visited and underwent surgical treatment with titanium plate and screw fixation at the Department of Oral and Maxillofacial Surgery, Viet Tiep Hospital, from January 2023 to October 2023 due to trauma. Patient records and CT scan films were fully collected. Mandibular fractures were classified based on anatomical location. Results: The study found that 90% of patients with mandibular fractures underwent surgery within a week of trauma, with most requiring two titanium plates for fixation (63.3%). Post-operative recovery was rapid, with 93.3% discharged within a week, and complications such as wound drainage (20%) and tooth extraction (6.7%) were minimal. Jaw fixation was required for 2-3 weeks in 56.7% of cases, while 10% of patients did not need fixation due to non-displaced fractures. Radiographic evaluations showed excellent outcomes in 83.3% of cases before discharge, with no poor results. At six months post-surgery, anatomical recovery was excellent in 96.7% of patients, with 93.3% achieving optimal functional and aesthetic outcomes. These findings highlight the efficacy and reliability of titanium plate fixation for mandibular fractures. Conclusion: Most patients were hospitalized for treatment within one week after surgery (93.3%), with none requiring more than two weeks. The majority underwent surgical fixation using two titanium plates (63.3%). Jaw fixation was predominant, with most patients requiring fixation for 2-3 weeks. One week after surgery, 83.3% of patients had good outcomes, with no poor results reported. At six months post-surgery, the proportion of patients with excellent outcomes increased to 93.3%, with no recorded poor results in terms of anatomical alignment, functionality, or aesthetics.

Topic: Facial Trauma and Fracture Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
The analysis of health products conference marketing mode

Objective make health products industry develop better and to pefect the conference marketing mode.Method Literature research about Principles of Marketing and analyzing some classic cases.Results get the Strength and weakness of conference marketing.Conclusion conference marketing has to contact with some other methods to make itself and the health products industry develop healthily.

Topic: Conferences and Exhibitions Management
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences