jimnoneill/paper-to-field-training huggingface dataset:
Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells

Abstract Tissue engineering aims to utilise biologic mediators to facilitate tissue regeneration. Several recombinant proteins have potential to mediate induction of bone production, however, the high production cost of mammalian cell expression impedes patient access to such treatments. The aim of this study is to produce recombinant human osteopontin (hOPN) in plants for inducing dental bone regeneration. The expression host was Nicotiana benthamiana using a geminiviral vector for transient expression. OPN expression was confirmed by Western blot and ELISA, and OPN was purified using Ni affinity chromatography. Structural analysis indicated that plant-produced hOPN had a structure similar to commercial HEK cell-produced hOPN. Biological function of the plant-produced hOPN was also examined. Human periodontal ligament stem cells were seeded on an OPN-coated surface. The results indicated that cells could grow normally on plant-produced hOPN as compared to commercial HEK cell-produced hOPN determined by MTT assay. Interestingly, increased expression of osteogenic differentiation-related genes, including OSX , DMP1 , and Wnt3a , was observed by realtime PCR. These results show the potential of plant-produced OPN to induce osteogenic differentiation of stem cells from periodontal ligament in vitro , and suggest a therapeutic strategy for bone regeneration in the future.

Topic: Transgenic Plants and Applications
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics

Hunting for meat was a critical step in all animal and human evolution. A key brain-trophic element in meat is vitamin B 3 /nicotinamide. The supply of meat and nicotinamide steadily increased from the Cambrian origin of animal predators ratcheting ever larger brains. This culminated in the 3-million-year evolution of Homo sapiens and our overall demographic success. We view human evolution, recent history, and agricultural and demographic transitions in the light of meat and nicotinamide intake. A biochemical and immunological switch is highlighted that affects fertility in the ‘de novo’ tryptophan-to-kynurenine-nicotinamide ‘immune tolerance’ pathway. Longevity relates to nicotinamide adenine dinucleotide consumer pathways. High meat intake correlates with moderate fertility, high intelligence, good health, and longevity with consequent population stability, whereas low meat/high cereal intake (short of starvation) correlates with high fertility, disease, and population booms and busts. Too high a meat intake and fertility falls below replacement levels. Reducing variances in meat consumption might help stabilise population growth and improve human capital.

Topic: GABA and Rice Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Macular Development in Aggressive Posterior Retinopathy of Prematurity

Purpose . To report anatomic outcomes after early and confluent laser photocoagulation of the entire avascular retina, including areas in close proximity to the fovea, in patients with APROP. We aspire to demonstrate fundoscopic evidence of transverse growth and macular development following laser treatment in APROP. Methods . Retrospective review of 6 eyes with APROP that underwent confluent laser photocoagulation of the entire avascular retina. Photographic fundoscopic imaging was performed using the RetCam to compare outcomes after treatment. Results . Mean birth weight and gestational age were 704.8 g and 24.33 weeks, respectively. There were 2 females and 1 male. The average time to laser was 9.3 weeks after birth, with the mean postmenstrual age of 34 weeks. Two eyes had zone 1 and 4 eyes had posterior zone 2 disease. Three eyes developed 4A detachments, which were successfully treated. All 6 eyes experienced transverse growth, with expansion of the posterior pole and anterior displacement of the laser treatment. Conclusion . Confluent photocoagulation of the entire avascular retina, regardless of foveal proximity, should be the mainstay for treating APROP. Examination should be conducted within 5–10 days to examine areas previously hidden by neovascularization to ensure prudent therapy. Macular development involves both transverse and anterior-posterior growth.

Topic: Retinopathy of Prematurity Studies
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
SEE PROFILE

*S Supporting Information ABSTRACT: Thin film morphologies of a 75.5 kg/mol polystyrene-block-polydimethylsiloxane (PS-b-PDMS) diblock copolymer subject to solvent vapor annealing are described. The PS-b-PDMS has a double-gyroid morphology in bulk, but as a thin film the morphology can form spheres, cylinders, perforated lamellae, or gyroids, depending on the film thickness, its commensurability with the microdomain period, and the ratio of toluene:heptane vapors used for the solvent annealing process. The morphologies are described by self-consistent field theory simulations. Thin film structures with excellent long-range order were produced, which are promising for nanopatterning applications. Nanometer-scale architectures in thin films can be achieved from the self-assembly of block copolymers, where interfacial interactions, commensurability, confinement effects, and sur-face energy determine the microdomain morphology.1−9 The

Topic: Block Copolymer Self-Assembly
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Coroplastica dal Quartiere Ellenistico-Romano di Agrigento: un atelier-maison nell'Insula III?

This paper presents the data derived from the study of previously unpublished coroplastic materials discovered during excavations of the so-called Insula III of Agrigento’s Hellenistic-Roman Quarter. Beyond the ter- racottas themselves, the results of this analysis requires a reconsideration of the contexts in which they were excavated. In particular, the sheer quantity of coroplastics discovered within a single deposit in a modest room in the so-called “Casa delle Pelte” demands a reevaluation of the function of the Insula III’s northern area. Terracotta fragments with evidence of burn marks and other production markers, such as a mold for the mass production of Tanagra statuettes, suggest the existence of an ergasterion – perhaps a domestic atelier- maison equipped with a small oven, or a kiln in the immediate vicinity of the deposit. As to the purpose of this proposed kiln, while knowledge of the sacred areas within the urban grid of the city is still limited, a local ritual use for these statuettes seems likely. A provisional hypothesis, further contextual analyses of Agrigento’s coroplastic industry should clarify how unusual such an atelier might actually be.

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions

χ-separation, a novel mathematical model applied to multiecho T2*-images and T2-images shows that young RRMS patients with low disability exhibit higher remyelination capacity, which correlated with clinical disability over a 2-year follow-up.

Topic: RNA regulation and disease
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Proceedings of the ACM SIGKDD Workshop on Outlier Detection and Description

Traditionally, outlier mining and anomaly discovery focused on the automatic detection of highly deviating objects. It has been studied for several decades in statistics, machine learning, and data mining, and has led to a lot of insight as well as automated systems for the detection of outliers. However, for today's applications to be successful, mere identification of anomalies alone is not enough. With more and more applications using outlier analysis for data exploration and knowledge discovery, the demand for manual verification and understanding of outliers is steadily increasing. Examples include applications such as health surveillance, fraud analysis, or sensor monitoring, where one is particularly interested in why an object seems outlying.

Topic: Anomaly Detection Techniques and Applications
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Gowers Norm, Function Limits, and Parameter Estimation

Previous chapter Next chapter Full AccessProceedings Proceedings of the 2016 Annual ACM-SIAM Symposium on Discrete Algorithms (SODA)Gowers Norm, Function Limits, and Parameter EstimationYuichi YoshidaYuichi Yoshidapp.1391 - 1406Chapter DOI:https://doi.org/10.1137/1.9781611974331.ch96PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAboutAbstract Let be a sequence of functions, where p is a fixed prime and Fp is the finite field of order p. The limit of the sequence can be syntactically defined using the notion of ultralimit. Inspired by the Gowers norm, we introduce a metric over limits of function sequences, and study properties of it. One application of this metric is that it provides a simpler characterization of affine-invariant parameters of functions that are constant-query estimable than the previous one obtained by Yoshida (STOC'14). Using this characterization, we show that the property of being a function of a constant number of low-degree polynomials and a constant number of factored polynomials (of arbitrary degrees) is constant-query testable if it is closed under blowing-up. Examples of this property include the property of having a constant spectral norm and degree-structural properties with rank conditions. Previous chapter Next chapter RelatedDetails Published:2016eISBN:978-1-61197-433-1 https://doi.org/10.1137/1.9781611974331Book Series Name:ProceedingsBook Code:PRDA16Book Pages:viii + 2106

Topic: Limits and Structures in Graph Theory
Subfield: Discrete Mathematics and Combinatorics
Field: Mathematics
Domain: Physical Sciences
Clinical immunology and HIV infection.

Clinical immunologists play a major role in the multidisciplinary approach to the management of human immunodeficiency virus (HIV) infection and its complications in Australia, through involvement with the clinical and laboratory management of patients as well as with research on disease pathogenic mechanisms. Consequently, immunological monitoring of the pathogenic effects of chronic HIV infection is commonplace, allowing for studies on the clinical utility of immunological investigations as a means of monitoring the severity of HIV-induced immunopathology and immunodeficiency to be undertaken. Such studies have demonstrated the clinical utility of CD4+ T-cell assays, but studies on cutaneous delayed-type hypersensitivity have demonstrated that the cellular immunodeficiency induced by chronic HIV infection may be more complex than CD4+ T-cell depletion alone. In addition, the involvement of clinical immunologists has greatly facilitated studies on the pathogenic mechanisms underlying HIV-induced immunopathology. Such activities place Australia in a very advantageous position for future studies on the use of immune-based therapies for controlling the pathogenic effects of chronic HIV infection.

Topic: Immunodeficiency and Autoimmune Disorders
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Success through innovation and negotiations : land acquisition in India

This note highlights the key lessons from four State Highway projects in India (in the states of Tamil Nadu, Punjab, Uttar Pradesh and Gujarat) and the Rampur Hydroelectric power project in the state of Himachal Pradesh, India. These particular projects are exemplary given the manner in which issues like inadequate compensation and the typically lengthy process of land acquisition was addressed through innovative valuation and consultations.

Topic: Hydropower, Displacement, Environmental Impact
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Computer simulation of the dechanneling of low-energy protons and antiprotons passing through a crystal

A theoretical analysis is proposed for the CERN experimental data on the channeling of antiprotons with an energy of about 1 MeV. Computer simulation reproduces the basic regularities revealed by the experiment and points to a strong angular spread of antiprotons in dechanneling as compared to the dechanneling of protons.

Topic: Crystallography and Radiation Phenomena
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
[Lower limbs revascularization originated in the descending thoracic aorta].

The revascularization of the lower limbs through a bypass graft from the descending thoracic aorta is one of the most uncommon surgical procedures within the scope of the so-called "extra-anatomic revascularization". It is an highly selective procedure in terms of indications and is regarded as an effective hemodynamic alternative, with acceptable long-lasting results. Two patients who underwent successfully the operation are reported, followed by a discussion on the technical aspects, indications, complications and early and late results of the procedure.

Topic: Peripheral Artery Disease Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
LHD 4O-BC02-L01 #186378.1 (analyzed)

Luminance data of the plasma monitor camera. Time variation of the average and maximum luminance within the ROI (Region of Interests) of the plasma images observed by the 4-O port camera, where ROI is (618,434) - (702,550) of the original image of 1920x1080. The luminance value is between 0 and 255 in arbitrary unit.

Topic: Gastroesophageal reflux and treatments
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
FETHA School of Nursing Abakaliki ,2023/2024 Admission Form, Out

Admin Office:: ☎️07066-280-862 DR ANITA 07066-280-862 The Management of the school hereby inform the general public on the sales 07066-280-862 the general Nursing Admission form into the School of Nursing.And also the sales of two (2) years Post Basic Nursing Programme.contact the school Admin. DR ANITA 07066-280-862 on 07 for more details on how to purchase the form and register online.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Unsupervised deep semantic and logical analysis for identification of solution posts from community answers

These days' discussion forums provide dependable solutions to the problems related to multiple domains and areas. However, due to the presence of huge amount of less-informative/inappropriate posts, the identification of the appropriate problem-solution pairs has become a challenging task. The emergence of a variety of topics, domains and areas has made the task of manual labelling of the problem solution-post pairs a very costly and time consuming task. To solve these issues, we concentrate on deep semantic and logical relation between terms. For this, we introduce a novel semantic correlation graph to represent the text. The proposed representation helps us in the identification of topical and semantic relation between terms at a fine grain level. Next, we apply the improved version of personalised pagerank using random walk with restarts. The main aim is to improve the rank score of terms having direct or indirect relation with terms in the given question. Finally, we introduce the use of the node overlapping version of GAAC to find the actual span of answer text. Our experimental results show that the devised system performs better than the existing unsupervised systems.

Topic: Topic Modeling
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
UHF HIGH-T<sub><font>c</font></sub> SQUID

For the first time we have designed, constructed and investigated an UHF high-T c SQUID pumped at 360 MHz at 77 K. The SQUID is based on an one-hole interferometer with a microbridge Josephson contact made of bulk YBaCuO ceramics by the standard technique of mechanical scribing, followed by finishing with a high-voltage discharge electroerrosion. Magnetic flux sensitivity of the UHF SQUID as measured by the output signal of a quadratic detector with a dc amplifier of 40 kHz bandwidth was found to be about 5 × 10−5ϕ 0 / Hz 1/2 in the quasiwhite noise region (at a frequency over 700 Hz).

Topic: Physics of Superconductivity and Magnetism
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Exploration for plant pathogens against Taeniatherum caput-medusae (medusahead ryegrass).

Taeniatherum caput-medusae (medusahead ryegrass) is an invasive weed in the United States of America with origins in the Mediterranean region extending to central Asia. It is a member of the grass family, with seed germinating in the fall and continuing to grow all winter. Currently, it infests millions of hectares of land, primarily in California, Colorado, Nevada, Oregon, and Utah. Taeniatherum caputmedusae crowds out native plant species and is almost worthless as forage. Current management strategies have been ineffective. This study examines biocontrol, through the use of plant pathogens, as a possible management strategy. In the literature, a few plant pathogens, including Ustilago spp., Tilletia bornmuelleri, Puccinia spp. and Fusarium culmorum, have been reported to occur naturally or to infect T. caput-medusae through artificial inoculation. Several Ustilago spp., a Tilletia sp., two Puccinia spp. and Fusarium arthrosporioides have been found during surveys in the native habitat of T. caputmedusae. Preliminary studies have begun to identify the species and determine their host range and impact. A completed study involving F. arthrosporioides showed that it was not host-specific and, therefore, it is not being pursued as a biocontrol agent. Further explorations will continue to search for new pathogens and assess their host specificity.

Topic: Plant and fungal interactions
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Mukai-Umemura’s example of the Fano threefold with genus 12 as a compactification of <i>C</i><sup>3</sup>

Let ( X, Y ) be a smooth projective compactification with the non-normal irreducible boundary Y , namely, X is a smooth projective algebraic threefold and Y a non-normal irreducible divisor on X such that X – Y is isomorphic to C 3 . Then Y is ample and the canonical divisor K x on X can be written as K x = - r Y (1 ≦ r ≦ 4).

Topic: Algebraic Geometry and Number Theory
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Effect of Ailanthus species and seasons on yarn parameters of eri silk

Present research entails an in-depth analysis on the effect of two secondary host plants of eri silkworm viz., borpat (Ailanthus grandis Prain) and borkesseru (Ailanthus excels Roxb.) and seasons on yarn parameters of eri silk as quality of silk depends on food quality and rearing season. Seasons had significant effect on all the yarn parameters viz., yarn size, breaking load, tenacity and elongation except twist per inch. Significantly the highest yarn size (10.26s) was observed in autumn season which was at par with the spring season. But the maximum breaking load (0.67 kg) and tenacity (1.40 g/denier) were recorded in spring season and elongation (26.54%) in early summer season. Regardless of the seasons, significantly the higher breaking load (0.64 kg) and tenacity (1.51 g/denier) were recorded on the borkesseru leaves. The interaction effect of seasons and two host plants on eri silk yarn was found to be non-significant. Diversiform effect of both the seasons and the host plants pertaining to yarn characters were witnessed. It can be ensured that all the seasons and host plants are relevant with slight alteration in the yarn quality.

Topic: Silkworms and Sericulture Research
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Cultural citizenship, media and sport in contemporary Australia

Mediated sport has assumed an extraordinary position in contemporary global culture. It is enormously popular, especially when stimulated by both artful and ‘carpet bomb’ marketing and promotion. It is, correspondingly, in high commercial demand in the transition from scheduled, ‘appointment’ broadcast television to a more flexible, mobile system of on-demand viewing on multiple platforms. The ‘nowness’ of sport means that it is highly effective in assembling massive, real-time audiences in an era of increasing fragmentation both in terms of numbers and viewing rhythms. At the same time, sport routinely insinuates itself into the everyday lives of citizens in ways that are no more uniform than the people who encounter it. Even among enthusiastic participants in, and aficionados of, sport, there is considerable experiential diversity in engagement with it in mediated form. Socio-cultural variables such as age, gender, ethnicity and social class, as well as dispositions of sporting taste, are responsible for considerable differences in the practices associated with mediated sport. This article addresses current research on cultural citizenship and sport in Australia, drawing on qualitative data from Greater Western Sydney, Australia’s most demographically diverse region, in analysing the various ways in which citizens engage with sport as participants and spectators. It explores the research participants’ views concerning their rights to access ‘live’ mediated sport within a broad framework of cultural citizenship, analysing the tension between commercial and citizen relationships in the production of public culture. Finally, the article considers problems associated with such access, including with regard to the so-called ‘gamblification’ of sport.

Topic: Sport and Mega-Event Impacts
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Retracted: Breaking Stress Criterion That Changes Everything We Know about Materials Failure

The perennial deficiencies of the failure models in the materials field have profoundly and significantly impacted all associated technical fields that depend on accurate failure predictions. The heart of this study is the presentation of a methodology that identifies a newly derived one-parameter criterion as the only general failure theory for noncompressible, homogeneous, and isotropic materials subjected to multiaxial states of stress and various boundary conditions, providing the solution to this longstanding problem. This theory is the counterpart and companion piece to the theory of elasticity and is in a formalism that is suitable for broad application. Utilizing advanced finite-element analysis, the maximum internal breaking stress corresponding to the maximum applied external force is identified as a unified and universal material failure criterion for determining the structural capacity of any system, regardless of its geometry or architecture. A comparison between the proposed criterion and methodology against design codes reveals that current provisions may underestimate the structural capacity by 2.17 times or overestimate the capacity by 2.096 times. It also shows that existing standards may underestimate the structural capacity by 1.4 times or overestimate the capacity by 2.49 times. The proposed failure criterion and methodology will pave the way for a new era in designing unconventional structural systems composed of unconventional materials.

Topic: Structural Response to Dynamic Loads
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences