jimnoneill/paper-to-field-training huggingface dataset:
Integration of Boltzmann machine and reverse analysis method

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Mamman Mamuda, Saratha Sathasivam; Integration of Boltzmann machine and reverse analysis method. AIP Conference Proceedings 22 October 2015; 1682 (1): 020023. https://doi.org/10.1063/1.4932432 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search

Topic: Neural Networks and Applications
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Non-Coding Sequences Regulating Eukaryotic Gene Expression

Gene expression in eukaryotes is a complex process that is involved with many levels from DNA transcription to mRNA posttranscriptional processing and posttranslational modification.It is the precise execution of these regulations that ensures the faithful completion of biological processes.The complexity of eukaryote certainly requires a more complex and precise regulation mechanism of gene expression.This is the main reason why most of the eukaryotic genome is non-coding sequences.Cis-acting elements,repetitive sequences,introns,untranslated regions and non-coding RNAs are non-coding sequences that play important roles in regulating expression of eukaryotic genes.Cis-acting elements interact with trans-acting factors to regulate gene expression in the transcription.Repetitive sequences can influence the chromatin structure.Introns and untranslated regions mainly regulate the gene expression at the level of post-transcription.Non-coding RNAs control various levels of gene expression.Here the authors review these non-coding sequences that regulate gene expression and their regulation mechanisms.

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CLONING, EXPRESSION AND CHARACTERIZATION OF CHIMERIC BACILLUS THERMOCATENULATUS LIPASE IN E. COLI

Bacterial lipases are members of α/β hydrolase family that hydrolyzed triacylglycerol at the water- lipid interface. Bacillus thermocatenulatus lipase 2 (BTL2) is a thermoalkalophilic lipase that shows optimal activity at 60–75 oC and pH 8–10. BTL2 is an important research target because of its potential industrial applications. At the present study chimeric Bacillus thermocatenulatus lipase contain the consensus sequence of Candida rugosa lipase (207Gly-Glu-Ser-Ala-Gly211) at the nucleophilic elbow region was cloned and expressed in E. coli as secretion protein. Finally, Catalytic activity of chimeric lipases was evaluated at presence of various triglycerides as substrates and the effects of different parameters such as temperature, pH, detergents, organic solvents and metal ions were evaluated on chimeric enzyme activity using a pH-stat assay. The results showed that the chimeric enzyme is most active to C4 substrate, (pH 9.0) and 60 oC. As well as enzyme activity has increased in the presence of organic solvents, N-Hexane, N-heptane, methanol, chloroform and detergents such as Triton X -100, Tween 20, Tween 40. Also, metal ions, respectively decreased general effect on the enzyme activity in chimeric lipase.

Topic: Enzyme Catalysis and Immobilization
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Prevalence of urinary tract infections in febrile children and role of urine interleukins in diagnosis

Background: Urinary tract infections (UTI) are common in the paediatric age group and can contribute to permanent renal damage. Urine culture takes a minimum of 48 hours, thus delaying treatment in suspect cases. It is also expensive and requires training of laboratory technologists. Early diagnosis is important in prevention of serious sequelae such as hypertension and end stage renal disease. Determination of burden of the problem within a population allows appropriate allocation of diagnostic and management resources. Urine interleukins are postulated to be useful adjuncts in diagnosis of UTI.\nObjectives: The primary objective was to determine the prevalence of UTI in febrile children aged 12yrs and below, at theAga KhanUniversityHospital. The secondary objective was to determine the diagnostic utility of urine interleukin 8 (IL-8) and interleukin 6 (IL-6), in detection of UTI using urine culture as the gold standard.\nMethodology: This was a cross-sectional survey conducted at the Aga Khan University Hospital,Nairobi between March and August 2010. All patients ≤12 years of age with fever presenting at theAga KhanUniversityHospital were enrolled .The minimum sample size was 92. Consecutive sampling was carried out until sample size was achieved. Urine samples were collected as mid stream for toilet trained children and urethral catheterization for children ≤two years of age after consent was obtained.\nPrevalence of UTIs was determined and a 2 by 2 contingency table was used in the calculation of the diagnostic utility of urine IL-6 and IL-8.ROC curves were plotted to illustrate sensitivity and specificity of IL-6 &amp; 8 cut offs.\nResults: A total of 98 patients were enrolled, 52% were male and the mean age of patients recruited was 57.6 months (range 0-144 months). Prevalence of UTI was 13.3% (95%CI 7.95-21.4) and 69% of patients with UTI were female. The sensitivity, specificity, positive and negative predictive values of IL-6 were 50% (18.7-81.3%), 69.2% (57.8-79.2%), 17.2% (5.85-35.8%) and 91.5% (81.3-97.2%) while for IL-8 they were 20% (2.52-55.6%), 98.7% (93.1-100%), 66.7% (9.43-99.2%) and 90.6% (82.3-95.8%) respectively. Likelihood ratio for urine IL-6 was 1.6 at &gt;1.8pg/ml (.794-3.24) and 15.6 (1.55-157) for IL-8 at &gt;200pg/ml. Confidence intervals (95%) are shown in brackets.\nConclusion: The overall prevalence of UTI in febrile children at the Aga Khan University Hospital, Nairobi was noted to be similar to that reported in Kenya and higher than that in developed countries. The diagnostic utility of urine interleukins was found to be poor and unsuitable as screening tests but useful adjuncts in ruling out UTI. Although a larger study with enough power to determine actual diagnostic utility of IL6/8 would be most appropriate, it is unlikely that a stronger case can be made for these more expensive tests compared to the basic cheaper tests with higher diagnostic utility.

Topic: Urinary Tract Infections Management
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Prevalence of Chronic Kidney Disease in Individuals With Type 2 Diabetes Within Primary Care: A Cross-Sectional Study

Aims:To assess the prevalence and risk factors for chronic kidney disease (CKD) among adults with type 2 diabetes within primary care.Methods:This cross-sectional study evaluated 1319 individuals receiving standard care across 26 primary units from July 2017 to January 2023. The estimated glomerular filtration rate (eGFR) and albuminuria were used for the diagnosis of CKD. CKD was defined by eGFR values of &lt;60 mL/min/1.73 m<sup>2</sup> and/or albumin-to-creatine ratio ≥30 mg/g. Logistic regression was applied to identify factors associated with CKD and study variables.Results:The median age of participants (60.6% females) was 55 years and the median diabetes duration was 10 years. The overall CKD prevalence in the study population was 39.2%. Within the CKD group, the prevalence rates of albuminuria, albuminuria coupled with low eGFR and isolated low eGFR were 72.1%, 19%, and 8.9%, respectively. The prevalence of CKD was 30.6% among participants under 40 years old and a higher value was observed in middle-aged adults with early-onset diabetes (at age &lt;40 years) compared with the later-onset group. Multivariable analyses identified associations between CKD and factors such as age, the male sex, diabetes duration, hypertension, retinopathy, and metformin use.Conclusion:A relatively high prevalence of CKD, especially in non-elderly adults, was revealed in this primary care study. Early recognition strategies for CKD are crucial for timely prevention within primary care.

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Is PTSD-Phenotype Associated with HPA-Axis Sensitivity?: The Endocannabinoid System in Modulating Stress Response in Rats

Endocannabinoids play a role in adaptation to stress and regulate the release of glucocorticoids in stressed and unstressed conditions. We recently found that basal corticosterone pulsatility may significantly impact the vulnerability for developing post-traumatic-stress-disorder (PTSD), suggesting that the endocannabinoid system may contribute to its development. To examine this, we exposed rats to predator scent stress (PSS). Behavioral reactions were recorded seven days post-PSS. Cerebrospinal fluid (CSF) was collected from anesthetized rats shortly after PSS exposure to determine the levels of 2-arachidonoyl glycerol (2-AG) and anandamide (AEA). To correlate between endocannabinoids and corticosterone levels, rats were placed in metabolic cages for urine collection. To assess the levels of endocannabinoids in specific brain regions, rats’ brains were harvested one day after behavioral analysis for staining and fluorescence quantification. Moreover, 2-AG was elevated in the CSF of PTSD-phenotype rats as compared with other groups and was inversely correlated with corticosterone urinary secretion. Eight days post-PSS exposure, hippocampal and hypothalamic 2-AG levels and hippocampal AEA levels were significantly more reduced in the PTSD-phenotype group compared to other groups. We posit that maladaptation to stress, which is propagated by an abnormal activation of endocannabinoids, mediates the subsequent stress-induced behavioral disruption, which, later, reduces neuronal the expression of endocannabinoids, contributing to PTSD symptomology.

Topic: Cannabis and Cannabinoid Research
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Magnetic Properties of Superconducting Vanadium

Isothermal magnetization data were obtained for an annealed single crystal of vanadium (resistivity ratio $\frac{{\ensuremath{\rho}}_{273\mathrm{K}}}{{\ensuremath{\rho}}_{4\mathrm{K}}}=450$) in prolate spheroidal form in the temperature interval from $T=1.4$ K to ${T}_{c}(=5.43 \mathrm{K})$, which was measured to be 5.43 \ifmmode\pm\else\textpm\fi{} 0.02 K. To minimize surface pinning and increase the reversibility of the bulk magnetization, the sample surface was subjected to an oxidation treatment. Values of the thermodynamic critical field ${H}_{c}(t)$ determined from the data are in good accord with the earlier results of Radebaugh and Keesom, and the Ginzburg-Landau parameter was deduced from the measurements to be $\ensuremath{\kappa}(1)=0.85\ifmmode\pm\else\textpm\fi{}0.02$. In the limit of infinite electronic mean free path it is found that ${\ensuremath{\kappa}}_{0}=0.82$ for this sample. The temperature variations of ${\ensuremath{\kappa}}_{1}(t)$, ${\ensuremath{\kappa}}_{2}(t)$, and the parameter ${h}^{*}(t)=\frac{{H}_{c2}(t)}{{(\ensuremath{-}\frac{d{H}_{c2}}{\mathrm{dt}})}_{t=1}}$ are discussed and compared with previous work. The results tend to confirm the importance of Fermi-surface anisotropy effects in type-II superconductors in the clean limit.

Topic: Physics of Superconductivity and Magnetism
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
‘It is not only an artist village, it is much more than that’1. The binding and dividing effects of the arts on a community

Abstract The value of ‘the arts’ in community development is increasingly being recognized. This paper contributes to emerging insights on the various impacts of the arts on communities by highlighting when and how they can have binding and dividing effects on a community. We draw on a participatory research project conducted in Pingjum, a village in the Netherlands that hosts many cultural activities and in which many artists live. We discuss how the arts in Pingjum influence the community in the village. In our discussion, we pay attention to the sense of community that the arts generate, the meeting opportunities they provide and how the community is engaged by some artists. Our study shows that the influence of the arts is context-dependent, with the arts having both binding and dividing effects on the community in Pingjum. In terms of the value of the arts for community development, we emphasize three key issues: that the arts (i) do not have only advantages for a community; (ii) do not engage the entire community; and (iii) could potentially contribute to community fragmentation. Given these issues, we argue that the arts should be considered as one of several supportive means in community development processes. Ideally, they are integrated into a wider community development strategy and planning, and exist alongside other associations and activities in a community. In this way, the arts can contribute to the robustness of a community and assist it in developing the capacity and resources to flourish.

Topic: Participatory Visual Research Methods
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
LHD sxcamera6O #125336.1

Fast 2-dimensional soft X-ray camera using 6 x 8 = 48 silicon photo diode array to investigate high frequency MHD instability with high mode number. Each diode has a large sensor area of 10 mm x 10 mm with small capacitance to measure signals with the short response time. The detection range is 1 - 10 keV with frequency range of DC - 100 kHz.

Topic: Viral Infectious Diseases and Gene Expression in Insects
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Pravastatin-induced colitis

We report an unusual case of pravastatin-induced colitis in an 80-year old lady. Onset of symptoms was noted within 48 h of starting the medication. Colonoscopy revealed diffuse ulceration throughout the colon with relative sparing of the rectum, with the biopsies showing ulceration and inflammation. The patient received a short course of steroid therapy and 5 months after stopping pravastatin, there was complete macroscopic and microscopic resolution of the colonic lesions. Drug interaction of pravastatin with amitryptiline could have resulted in this uncommon complication.

Topic: Colorectal Cancer Treatments and Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The Maternal Frame and the Rise of the Counterpublic Among Naga Women

Nagaland has witnessed violent conflict for over five decades. It is a heavily militarized space where draconian laws like the Armed Forces Special Powers Act allow army personnel to go unchallenged even after committing violent crimes. Few women have used their tradition-specific gendered role strategically to subvert gender norms and exhibit agency against violence within the conflict situation and the systemic violence that bars them from entering the public-political sphere. This article studies how women from the Naga tribal communities use their tradition-specific gender roles of motherhood to gain agency and resist the formation of a hostile, gendered social space.

Topic: Gender, Security, and Conflict
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Detection of regulation of family size after births of affected children

For family data where some of the children may have a certain inherited disorder, the number of affected children has usually been assumed to be binomially distributed given the total number of children in the family. In this assumption is included the assumption that the distribution of the total number of children does not depend on the probability that a child is affected. For many disorders this assumption is unlikely to hold because the birth of an affected child may lead either to some sort of family limitation or to some sort of overcompensation. In such cases models other than the binomial distribution have to be used.

Topic: Assisted Reproductive Technology and Twin Pregnancy
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes

In diabetic patients, the incidence of clinically manifested deficits in peripheral nervous system function increases with duration of disease and is approx 50% after 25 yr of disease. The resulting diabetic neuropathies comprise a group of distinct disorders that can affect both somatic and autonomic nerves, the most common of which is symmetric sensory polyneuropathy. Clinical signs of overt human diabetic neuropathy include decreases in nerve conduction velocity and action potential amplitude and in resistance to ischemic conduction failure. These abnormalities may be accompanied by sensory deficits and, in some cases, severe pain. In diabetes of long standing, morphological deterioration is evident, and both nerve fiber loss and segmental demyelination may occur.

Topic: Pain Mechanisms and Treatments
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Optimal temperature profile for an ammonia reactor

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimal temperature profile for an ammonia reactorBengt Maansson and Bjarne AndresenCite this: Ind. Eng. Chem. Process Des. Dev. 1986, 25, 1, 59–65Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/i200032a010https://doi.org/10.1021/i200032a010research-articleACS PublicationsRequest reuse permissionsArticle Views698Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

Topic: Ammonia Synthesis and Nitrogen Reduction
Subfield: Catalysis
Field: Chemical Engineering
Domain: Physical Sciences
[Ceftazidime for the treatment of infections in neutropenic children].

Ceftazidime in doses of 100 mg/kg/day was used, combined with netilmicin 6 mg/kg/day, as first-line treatment in two successive studies conducted on febrile neutropenic children (neutrophils less than 500/mm3). Study n. 1, performed at the Infantile Haematology unit of Saint Louis hospital, Paris, included 75 children. Study n. 2 was a multicentre study involving 88 children from 11 medical centres. The children's age in both studies ranged from 2 months to 16 1/2 years (mean 7 years). The percentage of bacteriologically documented febrile episodes was 45 per cent (34/75 and 39/88), and the most frequent infections were those caused by Gram-positive cocci (56 and 58 per cent respectively of the cases). Vancomycin 40 mg/kg/day was introduced if fever was still present 48 hours after the beginning of the antibiotic therapy. Effective treatments were continued until the neutropenia was corrected. These children were being treated for acute leukaemia, lymphoma, solid tumours or bone marrow aplasia. In study n. 1 apyrexia was obtained in 85 per cent of the cases with the ceftazidime-netilmicin combination and in 91 per cent of the cases after addition of vancomycin. The initial therapy was effective in all patients with a documented infection. There were tow super-infections with septicaemia: one due to Streptococcus D, the other to Staph. epidermidis. In study n. 2 73 per cent of the patients were apyretic after the first combination and 85 per cent after vancomycin was introduced. In proven infections the ceftazidime-netilmicin combination was effective in 30 cases and in another 6 cases after addition of vancomycin. Three patients remained febrile until they came out of aplasia. In all cases the bacterial cultures were sterilized by the ceftazidime-netilmicin combination. There was no superinfection. The mean duration of antibiotic therapy was 21 days in study n. 1 and 14 days in study n. 2. The drugs were perfectly tolerated both clinically and biochemically. No death occurred in the two studies. Thus, owing to its broad spectrum, effectiveness and safety ceftazidime is a very useful antibiotic when combined with netilmicin as first-line treatment of febrile neutropenic children.

Topic: Neutropenia and Cancer Infections
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Effects of mindful emotion regulation on parents’ loneliness and social support: A longitudinal study during the coronavirus disease 2019 (COVID-19) pandemic in the United States

The COVID-19 pandemic has introduced unprecedented challenges and demands for parents or caregivers of children who experienced disruptions in social support and feelings of isolation. Mindful emotion regulation may be a resilient factor for parents’ psychosocial outcomes. Mindful emotion regulation refers to individuals’ inherent capacities to regulate emotions mindfully, i.e., through paying attention to one’s experiences in the present moment nonjudgmentally. Based on the theoretical and empirical literature associating mindful emotion regulation with loneliness and perceived social support, the current study tested the effects of mindful emotion regulation on later changes in perceived social support and loneliness in U.S. parents during the pandemic. Participants were 147 parents/caregivers who were living with at least one child or adolescent in their household during the pandemic in the USA. Data were collected from a national online sample at four time points: baseline (April 7–21, 2020), 30-, 60-, and 90-days later. Results of longitudinal mediational structural equation modeling showed that mindful emotion regulation was directly associated with increased perceived social support and decreased loneliness. Moreover, mindful emotion regulation was also associated with perceived social support indirectly through its effects on loneliness. Focusing on the needs of parents is important for promoting family and child wellbeing to ameliorate negative health consequences. More research is needed to elucidate whether and how mindful emotion regulation may be beneficial for parents in the social relationship domain.

Topic: COVID-19 and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
How does ageing affect the wound healing process?

While wound repair is believed to be impaired in older people, there is no consensus on the precise mechanisms involved in delayed healing. Studies are often unable to determine whether ageing alone is responsible or if systemic factors such as medication, nutrition or vascular effects may be synergistic. This paper reviews the research literature on the effects of ageing on various aspects of wound healing.

Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences