jimnoneill/paper-to-field-training huggingface dataset:
Compressive and Flexural Strength Property Enhancement for Fibre Reinforced M30, M50 and M80 Grade Concrete Using Foundry Sand (FS) and Crushed Concrete Waste (CCW)

Now days, many research works are carried for all grades of concrete to make the concrete most economical and durable there by adding the supplementary cementitious materials and alternative replacement aggregates. In this research work deals with the experimental investigation of mechanical properties of the M30, M50 and M80 grade concrete by replacing the fine and coarse aggregate by foundry sand and crushed concrete waste respectively. Mix design procedures were followed as per IRC44:2017 guidelines and recommendation. Proper dosage of super plasticizer (SP) was maintained in the concrete to make it better performed. In this present investigation, a Poly Propylene fibre (PPF) of 0.3% by weight of the cement is used. Mechanical properties such as Compressive strength and Flexural Strength were determined by preparing the respective mould sizes for specific test and are cured for 7, 14 and 28 days and result obtained for respective days were tabulated and discussed.

Topic: Materials Engineering and Processing
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
109. Seroprevalence of Protective Antibodies against Varicella, Hepatitis-A and Dengue among Indian Children, Adolescents and Adults

Abstract Background Varicella, Hepatitis-A and Dengue cause significant disease burden in our country. Estimation of age-wise seroprevalence of antibodies against these diseases not only help us in understanding age-specific incidence rates and susceptibility, but also help policy makers in deciding need and timing of vaccination. None of these vaccines are part of current national immunization program in India, yet. Methods In this observational cross-sectional study, apparently healthy children (9-12 years), adolescents (15-18 years) and adults (25-30 years) attending OPD of a tertiary care hospital in Northern India over two-year period (July 17- June 19) were enrolled after taking informed written consent, and their 3-ml venous blood sample was collected. Ethical clearance was obtained from Institute Ethics committee, before enrolling subjects. Serum was tested for IgG antibodies using specific commercial ELISA kits. Those who received received Hepatitis-A or Varicella vaccination in past were excluded from enrollment. Results Out of total 240 subjects (M:F=117:123) enrolled, 75 were children, 75 adolescents and 90 adults in specified age groups. Mean age in these three groups were 11.04, 16.52 and 26.53 years respectively. In our study, antibodies (IgG) against Varicella were &amp;gt;12 U/ml (seroprotective) in 36% (27/75), 74.6% (56/75), 64.5% (58/90) in children, adolescent and adults in specified age groups, respectively. Similarly, the antibodies (IgG) against Hepatitis-A were &amp;gt;10 U/ml (seroprotective) in above three groups were 68% (51/75), 85.3% (64/75), 95.5% (86/90). For dengue IgG antibodies also, seropositivity rates in above three groups were 37.3% (28/75), 62.7% (47/75), 53.3% (48/90). Conclusion Large proportion of children, adolescents and adults remain susceptible to Varicella and Hepatitis-A infection in India. Early childhood vaccination with Varicella and Hepatitis-A vaccines should be a part of National Immunization Programme in India, as a part of preventive strategy. Our study also showed a large proportion of children, adolescents and adults remain seronegative for Dengue antibodies in various age groups. Therefore, if currently available dengue vaccine (Dengvaxia) has to be used in our population, it can only be used after individual screening. Disclosures All Authors: No reported disclosures.

Topic: Hepatitis Viruses Studies and Epidemiology
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Novel reconstruction techniques for detecting low mass dark matter in the SuperCDMS experiment and characterization of SuperCDMS SNOLAB detectors

The existence of dark matter has been inferred through many pieces of astrophysical evidence. However, much about its nature is unknown to this day. The several decades-long search for dark matter has given rise to many experiments and even more dark matter candidates. SuperCDMS is a direct detection experiment that uses cryogenic detectors to probe interactions of dark matter particles with Standard Model particles. Work done towards advancing two frontiers of the SuperCDMS SNOLAB experiment will be the main points of discussion in this thesis – (a) the characterization of the new SuperCDMS SNOLAB detectors, and, (b) the development of novel event reconstruction techniques for the experiment. After introducing the motivation for dark matter and the current experimental techniques used to detect it, the thesis will introduce SuperCDMS detection principles and pre-requisite knowledge to motivate and understand most of the work described within. First, preliminary results will be presented from testing and characterizing SuperCDMS detector towers at the Cryogenic Underground TEst facility, a low background test facility at SNOLAB in Sudbury, Canada. The remainder of this thesis will focus on novel reconstruction techniques critical to achieving the experiment’s projected sensitivity post commissioning. This discussion is divided into two. The first aspect will present a detailed discussion of advanced reconstruction algorithms to fit data sampled at non-uniform speeds to keep within the bandwidths of the readout electronics and maintain low trigger thresholds at SuperCDMS SNOLAB. The second major development discussed will be a novel reconstruction technique called the N×M filter, which fits N channels with M shapes/templates simultaneously and develops a pipeline that integrates machine learning to achieve excellent resolution improvement. The key outcomes of this thesis are (a) capability demonstration of the SuperCDMS SNOLAB detectors, (b) development of a less memory-intensive algorithm to process non-uniformly sampled data, and, (c) demonstration of a two-fold improvement and nearly a fourfold improvement in energy resolution in old and new data sets using the N×M filter, respectively.

Topic: Dark Matter and Cosmic Phenomena
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Peer Review #1 of "Segmental analysis by speckle-tracking echocardiography of the left ventricle response to isoproterenol in male and female mice (v0.2)"

We studied by conventional and speckle-tracking echocardiography, the response of the left ventricle (LV) to a three-week continuous infusion of Isoproterenol (Iso), a non-specific beta-adrenergic receptor agonist in male and female C57Bl6/J mice.Before and after Iso (30 mg/kg/day), we characterized LV morphology and function as well as global and segmental strain.We observed that Iso reduced LV ejection in both male (-8.7%) and female (-14.7%)mice.Several diastolic function parameters were negatively regulated in males and females such as E/A, E/E', isovolumetric relaxation time.Global longitudinal (GLS) and circumferential (GCS) strains were reduced by Iso in both sexes, GLS by 31% and GCS by about 20%.For the segmental LV analysis, we measured strain, strain rate, reverse strain rate, peak speckle displacement and peak speckle velocity in the parasternal long axis.We observed that radial strain of the LV posterior segments were more severely modulated by Iso than those of the anterior wall in males.In females, on the other hand, both posterior and anterior wall segments were negatively impacted by Iso.Longitudinal strain showed similar results to the radial strain for both sexes.Strain rate, on the other hand, was only moderately changed by Iso.Reverse strain rate measurements (an index of diastolic function) showed that posterior LV segments were negatively regulated by Iso.We then studied the animals 5 and 17 weeks after Iso treatment.Compared to control mice, LV dilation was still present in males.Ejection fraction was decreased in mice of both sex compared to control animals.Diastolic function parameters, on the other hand, were back to normal.Taken together, our study indicates that segmental strain analysis can identify LV regions that are more negatively affected by a cardiotoxic agent such as Iso.In addition, cessation of Iso was not accompanied with a complete restoration of cardiac function after four months.

Topic: Cardiovascular Function and Risk Factors
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Stories of Blogs, E-books and Time: Slowdown, Participation and Resistance in Wu Ming’s Giap and &lt;i&gt;L’archivio e la strada&lt;/i&gt;

This paper analyses the relationship between Wu Ming’s blog Giap and the e-book Giap: L’archivio e la strada, where the writing collective gathered a selection of blog posts published between 2010 and 2012. Focusing on the temporal dimension of on-line and off-line reading practices, this paper demonstrates that the transmedia transfer of content from the blog to the e-book—a hybrid medium available both on-line and off-line—affects the experience of the reader offering an alternative reading rhythm, slowing it down and engendering a more thoughtful and critical approach to its content. The focus on the temporal dimension of reading practices must be framed into Wu Ming’s cultural project, primarily aimed at sabotaging and undermining the rhythm of life, production, and consumption imposed by Capitalism. As part of this project, the blog Giap promotes practices of resistance to the commodification of cultural products and impulsive forms of content consumption. In particular, the content available on Giap is protected by copy-left policies, while the comments to its most thoughtful posts are blocked until seventy-two hours after their publication. The transmedia transfer of posts from the blog to the e-book reorders their sequence, establishes a different relationship between reader and content and encourages the latter to reflect on the texts within a restructured temporal dimension. The publication of the e-book therefore represents a further form of slowdown that brings about the possibility of an alternative to on-line impulsive reading practices, bridges on-line and off-line dimensions, tackles issues of accessibility and preserves its content from on-line dispersive fluxes.

Topic: Cultural Insights and Digital Impacts
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Approaches for prevention of tumors in patients with rhabdoid tumor predisposition syndrome

Abstract Patients with rhabdoid tumor predisposition syndrome (RTPS) harbor germline alterations in the epigenetic regulator genes SMARCB1 or SMARCA4. Patients usually present with atypical teratoid/rhabdoid tumor (AT/RT) of the brain or malignant rhabdoid tumor (MRT) arising outside the central nervous system. Intensive treatment can lead to remissions, however tumors frequently recur or synchronous or metachronous tumors appear. A maintenance or secondary prevention regimen may prevent these aggressive tumors. Potential maintenance regimens may include low-dose traditional chemotherapy or different epigenetic therapies designed to target the epigenetic imbalance that drives RTs. We here review several potential maintenance regimens that may be useful in RTPS.

Topic: Chromatin Remodeling and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
UNDERSTANDING OF HIGH-SPEED-TRAIN-INDUCED LOCAL VIBRATION OF A RAILWAY STEEL BRIDGE USING LASER MEASUREMENT AND ITS EFFECT BY TRAIN SPEED

ある鉄道鋼箱桁橋において発生した主桁ウェブの垂直補剛材下端回し溶接部付近の変状の原因を明らかにすることを目的として,1)レーザードップラー振動計を複数台用いた振動計測システムを構築し,2)垂直補剛材下端部に設置した補強材がある状態と一時的に撤去した状態の常時微動計測から局部振動モード形を同定し,さらに,3)局部応力と局部振動,列車速度との関係を詳細に計測および調査し,変状の主要因は台車の規則的な通過による主桁下フランジの局部的な振動であることを明らかにした.最後に,実測データを用いた簡易な解析モデルにより列車走行時の振動現象を説明し,局部振動に対する高速運転の影響を予測した.

Topic: Structural Health Monitoring Techniques
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
An Expert Recommendation System for Design Decision Making: Who Should be Involved in Making a Design Decision?

In large software engineering projects, designing software systems is a collaborative decision-making process where a group of architects and developers make design decisions on how to address design concerns by discussing alternative design solutions. For the decision-making process, involving appropriate individuals requires objectivity and awareness about their expertise. In this paper, we propose a novel expert recommendation system that identifies individuals who could be involved in tackling new design concerns in software engineering projects. The approach behind the proposed system addresses challenges such as identifying architectural skills, quantifying architectural expertise of architects and developers, and finally matching and recommending individuals with suitable expertise to discuss new design concerns. To validate our approach, a quantitative evaluation of the recommendation system was performed using design decisions from four software engineering projects. The evaluation not only indicates that individuals with architectural expertise can be identified for design decision making but also provides quantitative evidence for the existence of personal experience bias during the decision-making process.

Topic: Software Engineering Research
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Chloride Ion Transport by PITENINs across the Phospholipid Bilayers of Vesicles and Cells

Small-molecule-based Cl- ion carriers are gaining revived attention because of their recently discovered role toward anticancer activity. Herein, we showed that the anticancer agents, PITENINs, have an efficient transmembrane Cl- ion transport activity. Theoretical calculations, 1H NMR titration, and spectrophotometric analysis suggest that the PITENINs strongly bind with a Cl- ion. In addition to the lipophilicity, the presence of both acylthiourea and phenolic OH moieties of the compounds plays a crucial role in the transport of Cl- ions. Among the tested compounds, PIT-1 and DM-PIT-1 showed higher Cl- ion selectivity and transport efficiency. Mechanistic studies demonstrated that the potent compounds follow the H+/Cl- transport pathway. Cellular activity studies showed that the disruption of Cl- ion homeostasis by PIT-1 and DM-PIT-1 preferentially promotes apoptotic cell death.

Topic: Lipid Membrane Structure and Behavior
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Restaurant customers segmentation based on serving robots" attributes evaluation

본 연구는 인공지능(AI) 기술의 발전과 비대면서비스가 선호되고 있는 현실에 맞추어, 인간의 삶과 공존하게 될 서빙로봇의 속성을 검증하고 이에 따른 고객 세분화를 수행하였다. 외식업계에서 서빙로봇을 사용해본 경험이 있는 294명의 고객을 대상으로 최종 분석을 실시하였다. 분석에는 SPSS 통계 프로그램의 빈도분석, 기술통계분석, 신뢰도분석, 탐색적 요인분석, 군집분석, ANOVA, Scheffe 테스트, 교차분석을 수행하였다. 분석결과, 첫째, 서빙로봇의 속성은 의인관, 활동성, 호감성, 지능, 안전성으로 검증되었다. 둘째, 검증된 속성을 바탕으로 군집분석을 실시하여 3개의 군집이 도출되었다. 군집1은 ‘고평가’ 집단, 군집2는 ‘중간평가’ 집단, 군집3은 ‘저평가’ 집단으로 구분되었고, 군집별로 다양한 특성을 나타내는 결과가 확인되었다. 셋째, 전체 표본 중, ‘고평가’ 집단의 비율이 가장 낮게 나타났고, ‘고평가’ 집단의 경우 남성의 비율이 월등히 높게 확인되었다. 연령은 ‘고평가’ 집단의 경우는 고른 분포를 보였고, ‘중간평가’과 ‘저평가’ 집단의 경우 30대의 비율이 높게 나타났다. ‘고평가’ 집단은 월 소득이 높은 고객의 비율이 가장 높았고, 서빙로봇 사용 횟수도 높은 것으로 분석되었다. 그러나, 결혼여부, 교육수준, 직업, 거주지, 레스토랑 타입에 따른 집단 간 차이는 확인되지 않았다. 본 연구는 다양한 학술적, 실무적 시사점을 도출하였음에도 불구하고 여러 한계점 또한 보이고 있다.

Topic: Nutrition, Health and Food Behavior
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Respiratory Depression of Intravenous Hydroxyzine in Man

The effects of intravenous hydroxyzine and hydroxyzine with naloxone on respiration were determined in man. Drug effect was expressed as the shift in the 20-L intercept of the respiratory response curve measured by a rebreathing technique. The time-effect curve of hydroxyzine was found to be the same for hydroxyzine alone and in combination with naloxone, but significantly different from placebo or naloxone alone. The duration of respiratory depression in man resulting from hydroxyzine, 100 mg IV, is greater than 3 hours. Our data did not support the hypothesis that the respiratory depressant and recently discovered antinociceptive effects of hydroxyzine result from endorphin release or are mediated by opiate receptors.

Topic: Pharmacological Receptor Mechanisms and Effects
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Contextualizing Military Health and Trauma: Recommendations for Integrated Care and Couple-Centered Interventions

Military personnel and their family members are currently facing risks to their health and well-being, yet interventions such as prevention and treatment remain unsuccessful for many families. For instance, almost one-quarter of a million returning troops have been diagnosed with post-traumatic stress disorder (PTSD); however, the estimated prevalence of PTSD is grossly underestimated due to ineffective assessment. Further, only half of military PTSD sufferers are finding relief in their treatment. Through this literature review, assessment, prevention, and treatment recommendations to improve health outcomes for military personnel are provided by expanding previous medical models and incorporating biopsychorelational principles and data.

Topic: Posttraumatic Stress Disorder Research
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Abstract 22: Histone Deacetylase (HDAC) 4 Controls Neointimal Hyperplasia via Stimulating Proliferation and Migration of Vascular Smooth Muscle Cells

Histone deacetylases (HDACs) are transcriptional co-regulators. We have recently demonstrated that a class IIa HDAC, HDAC4 promotes reactive oxygen species (ROS)-dependent vascular smooth muscle inflammation and mediates the development of hypertension in spontaneously hypertensive rats. Pathogenesis of hypertension is in part modulated by vascular structural remodeling via proliferation and migration of vascular smooth muscle cells (SMCs). We thus examined whether HDAC4 controls SMCs proliferation and migration. In rat mesenteric arterial SMCs, small interfering RNA (siRNA) against HDAC4 inhibited platelet-derived growth factor (PDGF)-BB-induced SMCs proliferation as determined by a cell counting (51% inhibition, n=7) or bromodeoxyuridine incorporation assay (95% inhibition, n=6) and migration as determined by Boyden chamber assay (71% inhibition, n=3). Expression and activity of HDAC4 were increased by PDGF-BB (30% increase, n=5 and 170% increase, n=4, respectively). HDAC4 siRNA inhibited phosphorylation of p38 (69% inhibition, n=5) and heat shock protein (HSP) 27 (91% inhibition, n=5) and expression of cyclin D1 (58% inhibition, n=5) as measured by Western blotting. HDAC4 siRNA also inhibited PDGF-BB-induce ROS production as measured fluorometrically using 2’ 7’-dichlorofluorescein diacetate (77% inhibition, n=4) and nicotinamide adenine dinucleotide phosphate oxidase activity as measured by lucigenin assay (61% inhibition, n=4). A Ca 2+ /calmodulin (CaM)-dependent protein kinase (CaMK) II inhibitor, KN93 inhibited PDGF-BB-induced SMCs proliferation (58% inhibition, n=4) and migration (75% inhibition, n=3) as well as phosphorylation of HDAC4 (84% inhibition, n=4). In vivo, a class IIa HDACs inhibitor, MC1568 prevented neointimal hyperplasia in mice carotid ligation model (54% inhibition, n=6). MC1568 also inhibited increased activity of HDAC4 in the neointimal lesions. The present results for the first time demonstrate that HDAC4 controls PDGF-BB-induced SMCs proliferation and migration through activation of p38/HSP27 signals via ROS generation in a CaMKII-dependent manner, which may lead to the neointima hyperplasia in vivo.

Topic: Histone Deacetylase Inhibitors Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
“Fake it to make it”: exploring product counterfeiting in Türkiye

Purpose This paper aims to explore the issue of product counterfeiting in Türkiye and assess Türkiye’s role in the global supply chain of counterfeit goods. It sheds light on the supply-side dynamics of counterfeiting in the Turkish context. Design/methodology/approach Interviews were conducted with 46 key experts, including police officers, customs officers and trademark attorneys. The study also incorporated data from a documentary analysis of counterfeit products seized by the Bulgarian Customs. Findings The findings of this study highlight the significant role of Türkiye in international supply chains, serving as both a manufacturing hub for a wide array of counterfeit products and a crucial transit point for goods bound for European markets. This study suggests that counterfeiting serves as a source of livelihood for many individuals in Türkiye, with counterfeiters often justifying their activities by claiming they contribute to the country’s economy through job creation and the influx of foreign currency. Research limitations/implications While qualitative research is essential for exploring nuanced aspects and gaining in-depth insights, it may not provide the statistical robustness and generalizability associated with larger quantitative studies. Originality/value This paper is an original contribution to the understanding of product counterfeiting in Türkiye, a major counterfeit-producing country, with potential implications for the future of consumer protection and market integrity.

Topic: Global trade, sustainability, and social impact
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Development and optimization of amphiphilic self-assembly into nanostructured liquid crystals for transdermal delivery of an antidiabetic SGLT2 inhibitor

The anti-hyperglycemic sodium glucose co-transporter 2 inhibitor Canagliflozin (CFZ) represents a recent antihyperglycemic modality, yet it suffers from low oral bioavailability. The current work aims to formulate CFZ-loaded transdermal nanostructured liquid crystal gel matrix (NLCG) to improve its therapeutic efficiency. Pre-formulation study included the construction of pseudoternary phase diagrams to explore the effect of two conventional amphiphiles against amphiphilic tri-block copolymer in the formulation of NLCG. The influence of different co-solvents was also investigated with the use of monooleine as the oil. Physical characterization, morphological examination and skin permeation were performed for the optimized formulations. The formula of choice was further investigated for skin irritation and chemical stability. Pharmacodynamic evaluation of the successful formula was conducted on hyperglycemic as well as normoglycemic mice. In addition, oral glucose tolerance test was conducted. Results revealed the supremacy of Poloxamer for stabilizing and maximizing liquid crystal gel (LCG) area percentage that reached up to 12.6%. CFZ-NLCG2 isotropic formula showed the highest permeation parameters; maximum flux value of 7460 μg/cm<sup>2</sup> h and <i>Q</i><sub>24</sub> of 5327 μg/cm<sup>2</sup>. Pharmacodynamic evaluation revealed the superiority of the antihyperglycemic activity of CFZ-NLCG2 in fasting mice and its equivalence in the oral glucose tolerance test (OGTT) compared to the oral one. The obtained results confirmed the success of CFZ-NLCG2 in the transdermal delivery of CFZ in therapeutically effective concentration compared to the oral route, bypassing first pass effect; in addition, eliminates the possible gastrointestinal side effects related to the inhibition of intestinal sodium glucose co-transporter (SGLT) and maximizes its selectivity to the desired inhibition of renal SGLT.

Topic: Advancements in Transdermal Drug Delivery
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences