jimnoneill/paper-to-field-training huggingface dataset:
Supplementary Table 2 from Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in &lt;i&gt;RET&lt;/i&gt;-Rearranged Lung Adenocarcinoma

&lt;p&gt;Supplementary Table 2. siRNA sequences&lt;/p&gt;

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Do we need Moodle in medical education? A review of its impact and utility

Various learning management systems (LMSs) are available to facilitate the development, management, and distribution of digital resources for both face-to-face and online instruction. In recent decades, these methods have shown potential for greater efficiency compared to traditional "chalk and talk" approaches. Additionally, they have paved the way for the establishment of ubiquitous learning environments, marking a new era in education. In a trend accelerated by the coronavirus disease 2019 pandemic, LMSs have been increasingly adopted to overcome the restrictions inherent to in-person education. In medical education, LMSs such as Moodle, Canvas, Blackboard Learn, and others have been introduced and used to support teaching, learning, and assessment activities. Of these, Moodle stands out as the most popular choice for many medical schools and institutions, primarily due to its flexibility, functionality, and user-friendliness. The learning environment is gradually transforming from traditional in-person teaching to a hybrid educational approach, driven by the need to fulfill diverse educational demands. Numerous research studies have examined the usability of Moodle in medical education, demonstrating its effectiveness in addressing challenges related to adaptive personalized learning, collaborative learning, blended learning, and more. Consequently, Moodle has emerged as a valuable solution for medical educators seeking a versatile and robust platform to enhance their teaching methodologies. The present review focuses on the practical utilization of Moodle in medical education and the advantages it offers to this field.

Topic: Innovative Teaching Methods
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Whole body autoradiographic and quantitative tissue distribution studies with 14C-cefotaxime in the rat.

The absorption, distribution and elimination of radioactivity following intravenous (i.v.) or intramuscular (i.m.) administration of 14C-cefotaxime (14C-HR 756) to the rat has been examined by qualitative and quantitative techniques. After i.v. and i.m. doses to male albino animals radioactivity was extensively distributed throughout the body and rapidly eliminated with a predominant half-life of approximately 30 to 40 min. Maximum plasma levels for the i.m. dose were reached within 20 min and approximately 85% of the dose was recovered from the urine (74%) and faeces (11%) within 8 h after dosing. In all quantitative studies 100 +/- 5% of the dose was recovered within 24 h. Whole body autoradiography studies showed good distribution of radioactivity from the blood into the tissues including lung, liver, kidney, heart, bone marrow and the gastrointestinal tract. Lowest levels were seen in the eye and brain. There was limited placental transfer of radioactivity in 14-day pregnant animals although by day 18 of the gestation period radioactivity was detected in the foetus but distribution into individual organs and tissues could not be seen. There was no evidence to show that retention of radioactivity in pigmented tissues had occurred nor was there any suggestion of accumulation of radioactivity in any organ or tissue as a consequence of multiple dosing with 14C-cefotaxime.

Topic: Drug Transport and Resistance Mechanisms
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Comparison of three scattering models for ultrasound blood characterization

Ultrasonic backscattered signals from blood contain frequency-dependent information that can be used to obtain quantitative parameters reflecting the aggregation level of red blood cells (RBCs). The approach is based on estimating structural aggregate parameters by fitting the spectrum of the backscattered radio-frequency echoes from blood to an estimated spectrum considering a theoretical scattering model. In this study, three scattering models were examined: a new implementation of the Gaussian model (GM), the structure factor size estimator (SFSE), and the new effective medium theory combined with the structure factor model (EMTSFM). The accuracy of the three scattering models in determining mean aggregate size and compactness was compared by 2-D and 3-D computer simulations in which RBC structural parameters were controlled. Two clustering conditions were studied: 1) the aggregate size varied and the aggregate compactness was fixed in both 2-D and 3-D cases, and 2) the aggregate size was fixed and the aggregate compactness varied in the 2-D case. For both clustering conditions, the EMTSFM was found to be more suitable than GM and SFSE for characterizing RBC aggregation.

Topic: Ultrasound Imaging and Elastography
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
UNITED TERRITORIAL COMMUNITIES FINANCIAL CAPACITY STRENGTHENING IN THE CONDITIONS OF BUDGETARY DECENTRALIZATION

Стаття присвячена дослідженню фінансового потенціалу об'єднаних територіальних громад (ОТГ) в умовах бюджетної децентралізації та визначенню основних положень його зміцнення задля створення фінансових передумов сталого розвитку територій. Наведено хронологію розвитку поняття «фінансовий потенціал ОТГ» у вітчизняній економічній науці. Визначено послідовність етапів та пріоритетні напрями посилення фінансового потенціалу ОТГ. Встановлено, що особливої уваги потребують оцінка рівня й сили впливу фінансових ризиків та вдосконалення нормативно-правового підґрунтя регулювання діяльності суб'єктів економіки. Зроблено висновок, що використання додаткових можливостей посилення фінансового потенціалу ОТГ сприятиме підвищенню фінансової стійкості місцевих бюджетів та потребує дієвого державного регулювання й ефективного використання програмно

Topic: Economic Issues in Ukraine
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Evaluation of a Dutch Educational “Driving While Intoxicated (DWI)” Prevention Program for Driving Schools

A DWI prevention program for driving schools consisting of a videotape, slides, a textbook, and a manual was developed and evaluated. Effects of the program on knowledge, attitude, behavior intention, and self-reported DWI behavior were measured by means of a pretest, posttest, one-year follow-up evaluation design. Two-hundred and eight driving school students followed the program and participated in all three measurements. A control group of 228 pupils followed a traditional curriculum without the DWI program and also participated in all three measurements. Principal findings were that knowledge improved, attitudes and behavior intentions were already positive at pretest, DWI was equally reported by both groups, and there was a positive effect on riding with an intoxicated driver.

Topic: Substance Abuse Treatment and Outcomes
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
SOME PROPERTIES AND APPLICATIONS OF BERYLLIUM WIRE

The physical properties of Be are tabulated, and a description is given of the fabrication of Be wire. Graphs are presented showing tensile properties, formability, and electrical resistivity of annealed and hard drawn Be wire. Applications of Be wire, including properties of a Be filament wound composite structure are discussed. (TCO)

Topic: Mechanical stress and fatigue analysis
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Reducing the peak-to-average power ratio using unitary matrix transformation

A theoretical analysis is presented to show that in orthogonal frequency division multiplexing systems, the peak-to-average power ratio (PAPR) can be reduced by performing a unitary matrix transformation on the input vector of N symbols. The authors also prove that this transformation does not degrade the bit error rate (BER) or power spectral density (PSD) performance. Based on this, the inverse discrete Fourier transform matrix is proposed as the unitary matrix to reduce the PAPR. The simulation results show that the proposed scheme can obtain significant PAPR reduction while maintaining good performance in the BER and the PSD. To further evaluate the performance of the proposed scheme, the authors compare it with some well known PAPR reduction techniques by simulations. It is demonstrated that the proposed scheme can offer better system performance and achieve a better compromise with regard to the PAPR reduction, BER, spectral efficiency and computational complexity.

Topic: PAPR reduction in OFDM
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Additional file 4 of The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis

Additional file 4. Construction of in-frame deletion and complementation strains of theHAPS_0849gene inG. parasuis. (A and B) Schematic diagram of the HAPS_0849 mutant or complementation strain constructed in this study. Abbreviations: Kanr, kanamycin resistance gene; Gmr, gentamicin resistance gene; Up, upstream sequence of HAPS_0849; Dn, downstream sequence of HAPS_0849. (C) Locus structure of the HAPS_0849 mutant or complementation strain. Detection primers are shown as solid black arrows. (D) PCR analysis confirming the constructs. Lane M, DNA molecular marker; lanes 1–3, SC096, ΔHAPS_0849 and complementation strain with primers P21 and P22, as shown in this figure part C; lanes 4-6, the same strains with primers P23 and P24; lanes 7 and 8, ΔHAPS_0849 and its complementation strain with primers P9 and P10.

Topic: Microbial infections and disease research
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
A "cold" discharge mechanism for low-noise fast charge amplifiers

We present a new discharge mechanism for low-noise fast preamplifiers for /spl gamma/-ray spectroscopy. Such circuital solution has been conceived in the framework of the INFN Mars experiment, which imposes stringent requirements for both the signal-to-noise ratio and the rise time of the front-end preamplifiers. Basically, a noninverting low-gain (G) stage is interposed between the output of a conventional charge amplifier and the high-value feedback resistor. It can be easily found that this adds no noise but the discharge time constant is reduced by a factor G, because the voltage drop across the resistor is G times as high, and such is the discharge current. A similar effect could also be obtained in the standard charge amplifier by diminishing the feedback resistor by a factor G. But this would yield an increase of a factor G of its thermal current noise. In this sense our equivalent discharge resistor is "cold", because it carries a current noise G times as low. This permits us to use a relatively large feedback capacitance which inherently yields a fast risetime. A rise time of 15 ns and an overall electronic noise of 1.03 keV FWNM at 3 /spl mu/s shaping time have been obtained, with an input capacitance of 33 pF, and 1.5 pF feedback capacitor, 150 /spl mu/s discharge time constant.

Topic: Nuclear Physics and Applications
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Improved survival with percutaneous ethanol injection in patients with large hepatocellular carcinoma

Objective: To evaluate the efficacy of percutaneous ethanol injection in the management of patients with large hepatocellular carcinoma. Design: Prospective controlled study. Ten patients were randomized to receive percutaneous ethanol injection and five served as controls. Setting: Tertiary hospital. Participants: Fifteen patients with large (>5cm) lesions with or without cirrhosis and no ascites. Mean tumour size in the percutaneous ethanol injection group (82.5 ±59 cm2) and in the control group (87.1 ±58 cm2) was comparable. Intervention: Percutaneous ethanol injection was performed under ultrasound guidance. Repeated injections (mean 5.1±1.6 sessions) were given and a mean 38.8±8.3 ml ethanol was injected per patient until the lesion appeared 'marble like' at ultrasound. Results: There was a significant (P< 0.01 ) decrease in the median tumour size (median 14%; range, 0–68%) in nine of the 10 patients compared with a 20% increase in size in the untreated patients. Median survival in the percutaneous ethanol injection group was 9 months (range, 4–38 months) and 5 months in the control group (range, 1–8 months); the difference was significant (P<0.05). Conclusion: Percutaneous ethanol injection is a safe and effective technique which arrests tumour growth, may decrease tumour size and can improve survival in patients with large hepatocellular carcinoma.

Topic: Hepatocellular Carcinoma Treatment and Prognosis
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
The Danish Cartoons Reconsidered: Catholic Social Teaching and the Contemporary Challenge of Free Speech

The Danish cartoon controversy was extremely problematic for Muslims. But the publication of the cartoons also raised profound normative questions about speech for the Catholic Church as well. This article addresses the cartoon controversy in light of the Catholic social teaching's tradition on speech. In particular, the article addresses the issues of offensive speech; the relationship of speech and the secular; and the normative prioritization of the rights to the free exercise of religion and to freedom of speech.

Topic: Religious Education and Schools
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Design Concepts forHigh-Voltage, Variable-Capacit ance,

50OMW~~~~~~~ at±IIk, odt.1. V-CFUNDIMENTALS AND SIMULATION MODEL Thecostofanoffshore windfarmoperating withHVDC transmission (2,8,10)couldpotentially bereduced bytheA.Fundamentals direct generation ofHVDC powerasopposed tothemore Thelowpowerdensity ofelectrostatic machines within conventional approachof generator-transformer-rectifier conventional applications, whencompared toelectromagnetic

Topic: High-Voltage Power Transmission Systems
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Study of transductive learning and unsupervised feature construction methods for biological sequence classification

Next Generation Sequencing (NGS) technologies have led to fast and inexpensive production of large amounts of biological sequence data, including nucleotide sequences and derived protein sequences. These fast-increasing volumes of data pose challenges to computational methods for annotation. Machine learning approaches, primarily supervised algorithms, have been widely used to assist with classification tasks in bioinformatics. However, supervised algorithms rely on large amounts of labeled data in order to produce quality predictors. Oftentimes, labeled data is difficult and expensive to acquire in sufficiently large quantities. When only limited amounts of labeled data but considerably larger amounts of unlabeled data are available for a specific annotation problem, semi-supervised learning approaches represent a cost-effective alternative. In this work, we focus on a special case of semi-supervised learning, namely transductive learning, in which the algorithm has access during the training phase to the instances that need to be labeled. Transduction is particularly suitable for biological sequence classification, where the goal is generally to label a given set of unlabeled instances. However, a challenge that needs to be addressed in this context consists of identification of compact sets of informative features. Given the lack of labeled data, standard supervised feature selection methods may result in unreliable features. Therefore, we study recently proposed unsupervised feature construction approaches together with transductive learning. Experimental results on two classification problems, namely cassette exon identification and protein localization, show that the unsupervised features result in better performance than the supervised features.

Topic: Machine Learning in Bioinformatics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Coments on "Complexities of Large-Scale Technology Project Failure: Seattle Popular Monorail Authority"

(2008). Coments on 'Complexities of Large-Scale Technology Project Failure: Seattle Popular Monorail Authority' Public Performance & Management Review: Vol. 31, No. 3, pp. 479-482.

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
[Renal magnetic resonance].

MRI is very useful in the study of renal disease due to its high spatial resolution. Its cost, and because it is not widely available, have limited the indications of MRI to those cases whose diagnosis cannot be established by other imaging techniques (US and CT) and patients in whom iodated contrast material (i.e., allergy to iodine or renal failure) or ionizing radiation (i.e., pregnancy) is contraindicated. MR has a high diagnostic reliability in the evaluation of the extent of the renal tumors. MR angiography and MR urography permit adequate and non-invasive assessment of the vascular and collecting systems without the need to utilize iodated contrast agents.

Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
CogView3: Finer and Faster Text-to-Image Generation via Relay Diffusion

Recent advancements in text-to-image generative systems have been largely driven by diffusion models. However, single-stage text-to-image diffusion models still face challenges, in terms of computational efficiency and the refinement of image details. To tackle the issue, we propose CogView3, an innovative cascaded framework that enhances the performance of text-to-image diffusion. CogView3 is the first model implementing relay diffusion in the realm of text-to-image generation, executing the task by first creating low-resolution images and subsequently applying relay-based super-resolution. This methodology not only results in competitive text-to-image outputs but also greatly reduces both training and inference costs. Our experimental results demonstrate that CogView3 outperforms SDXL, the current state-of-the-art open-source text-to-image diffusion model, by 77.0\% in human evaluations, all while requiring only about 1/2 of the inference time. The distilled variant of CogView3 achieves comparable performance while only utilizing 1/10 of the inference time by SDXL.

Topic: Video Analysis and Summarization
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Behavioral Modeling of Class E Amplifiers via Modified Nodal Analysis Formulation

The behavioral model of class E amplifiers in the steady state are given via the modified nodal analysis (MNA) formulation. The MNA formulation that provides circuit equations is adopted in general-purpose circuit simulators such as SPICE. Even though the circuit configuration is changed，the circuit equations are easily obtained. Hence, the behavioral model can be certainly obtained without difficulty in the setting up of the circuit equations. To produce the behavioral model, the MOSFET included in the class E amplifier is replaced with an ideal switch. Each dynamical system that depends on the "on" and "off" states of the switch is categorized as a descriptor system in control theory. The behavioral model of the class E amplifiers is obtained, on the basis of control theory. The proposed method is applicable to behavioral modeling of other types of resonant power amplifiers.

Topic: Advanced Power Amplifier Design
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Regulatory mechanisms in cell-mediated immune responses. VIII. Differential expression of I-region determinants by suppressor cells and their targets in suppression of mixed leukocyte reactions.

The phenotypic expression of I-region determinants on cells producing and responding to MLR suppressor factor (MLR-TsF) was established in these studies. Alloantigen-activated MLR suppressor T cells (MLR-Ts), which produce MLR-TsF bearing gene products of the I-C subregion, were exposed to anti-I subregion sera and complement (C) before in vitro culture for MLR-TsF production. Suppressor activity was prevented by removal of cells bearing I-C determinants, whereas elimination of cells expressing I-A/B determinants had no effect. Interestingly, cytotoxic elimination of cells displaying I-J determinants also prevented MLR-TsF production. Admixture of anti-I-J and I-C antiserum-treated cells for MLR-TsF production failed to reconstitute suppressor activity, indicating that I-C and I-J gene products are expressed on a single population of cells critical to MLR suppression, rather than on distinct interacting subpopulations. Anti-I-C serum activity specific for I-C+ MLR-Ts was removed by adsorption with nylon wool-nonadherent splenic T cells and concanavalin A-activated thymocytes; adsorption with splenic B cells from anti-Thy-1,2 serum and C-treated spleen failed to remove relevant anti-I-C activity. These data suggest that regulatory I-C molecules, like I-J molecules, are preferentially expressed on T lymphocytes. Expression of I-C, or other I-region molecules on responder cell targets of MLR-TsF activity was also investigated. Responder cells were pretreated with anti-I subregion-specific sera in blocking or complement-dependent cytotoxic protocols before addition to MLR with MLR-TsF. Neither blocking nor the cytotoxic removal of cells bearing I-C or other I-region determinants from MLR responder populations interfered with MLR-TsF suppression. Because it has previously been demonstrated that MLR-TsF interacts optimally with activated, I-C syngeneic target cells, blocking and cytotoxic studies with anti-I subregion sera were also performed with responder cells activated by 24 h culture in MLR in the absence of MLR-TsF. Brief MLR-TsF pulse after antiserum treatment generated marked suppression regardless of blocking or absence of cells bearing serologically detected I-region determinants. I-C restricted suppression may thus be mediated not by interaction with I-C-bearing cells, but by target cells which exist in requisite association with populations of I-C+ cells.

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
DIABETIC FOOT ULCER GRADES

Diabetic foot is one of the most common complications of diabetes mellitus. The management and out come is very much dependent on proper assessment of foot ulcer severity. Objectives: To asses severity of diabetic foot and to find a correlation between Ankle Brachial Pressure Index (ABPI) and foot ulcer grades. Study design: Prospective study. Period: Jan 2001 to Dec 2003. Patients &amp; Methods and Setting: Patients with diabetic foot ulcers from all the medical and surgical units of Ayub teaching hospital Abbottabad were enrolled in the study. Results: Ankle Brachial Pressure Index (ABPI) levels revealed 5 (5.8%) with ABPI &lt; 0.5 for grade V, 8 patients (9.3%) ABPI 0.5 – 0.89 for grade IV, 18 patients (20.9%) ABPI 0.9-1 for grade III, 44 (51.2%) ABPI 0.9-1 for grade II, and 9 patients (10.5%) ABPI &gt; 1 for grade I diabetic foot ulcer. This data was analyzed via SPSS version 8.0. Conclusions: Ankle brachial pressure index is a good diagnostic tool to assess the lower extremity arterial disease in diabetic foot patients. ABPI readings should be cautiously interpreted as these may be falsely elevated in atherosclerotic patients.

Topic: Diabetic Foot Ulcer Assessment and Management
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences