jimnoneill/paper-to-field-training huggingface dataset:
Application of Analysis of Variance Method in Evaluating Construction Project Cost Performance: A Case Study of the Ministry of Finance Apartment Complex in Jayapura

In a stage of project implementation, there are problems that can cause a project to experience cost overruns so that it can cause losses. Seeing from the problems found to get maximum results with good quality and quality of work, it is necessary to evaluate and control costs on project profits as a whole. During the construction of the Jayapura Ministry of Finance flat project, there were 5 addendums when the structural work was carried out starting from January to August. These changes have a major impact on the overall time and cost of a project and have a direct and indirect adverse impact. The method used in a control is the Variant Analysis method. Control aims to be able to find out the cost of the most dominant variant during the working period. This method will show the difference between the implementation cost and the budget. The application of this variant analysis method is only in the work of the structure of the flats of the Ministry of Finance of Jayapura from January to August. Based on the analysis using the Variance Analysis method, the most dominant cost variance occurs in the 2nd floor work item with a variance value - RP. 58,239,966.11 then in the lower structure work with a variance value - RP. 46,060,221.40 and in the 3rd floor work with a variance value - Rp. 36,434,137.98.

Topic: Construction Project Management and Performance
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Proximate Analysis and Ecological Niche Modeling of Macrofungi in Ecologically Significant North-East India

Background and Objective: Macrofungi are diverse in their occurrence and topography. They play an inevitable role in agriculture, forestry, pharmacology and other industries. Studies on the diversity, occurrence, frequency distribution and nutritive values of the putative macrofungal genetic resources in the pristine locations of N.E. India holds the potential to attract the global economy and human welfare. The present survey was carried out to explore the less-explored macrofungal species diversity in nine undisturbed reserved forests of Dhemaji district, Assam. Materials and Methods: Mushroom identification was made using the standard taxonomy of fungi identification. Macrofungal proximate analysis for diverse categories was made using standard protocols. Ecological niche modelling of Hygrocybe splendidissima, macrofungi, enlisted in the IUCN red list of threatened species is made to identify the unexplored topography of the species and equally to report their utility in future conservation. Results: A total of 40 macrofungal species, belongs to 32 genera and 24 families were identified. Proximate nutritive values showed differences in the various edible mushrooms studied. The results of the analysis showed protein content, ranging from 10.65±0.03-42.76±0.021 g/100 g and carbohydrate content ranged from 27.67±0.03 70.09±0.028 g/100 g. Further ecological niche modelling of H. splendidissima, identified various forest areas in Northeast India that have suitable climatic conditions for reinforcement and in-situ conservation of the fungus. Conclusion: The present approach holds promises in exploiting the less explored and putative mushroom species of ecologically biodiverse regions like Northeast India.

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Mutant Huntingtin Causes Context-Dependent Neurodegeneration in Mice with Huntington's Disease

Huntington's disease (HD) mouse models that express N-terminal huntingtin fragments show rapid disease progression and have been used for developing therapeutics. However, light microscopy reveals no significant neurodegeneration in these mice. It remains unclear how mutant huntingtin induces neurodegeneration. Using caspase staining, terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, and electron microscopy, we observed that N171-82Q mice, which express the first 171 aa of mutant huntingtin, displayed more degenerated neurons than did other HD mouse models. The neurodegeneration was also evidenced by increased immunostaining for glial fibrillary acidic protein and ultrastructural features of apoptosis. R6/2 mice, which express exon 1 of mutant huntingtin, showed dark, nonapoptotic neurons and degenerated mitochondria associated with mutant huntingtin. In HD repeat knock-in mice (HdhCAG150), which express full-length mutant huntingtin, degenerated cytoplasmic organelles were found in both axons and neuronal cell bodies in association with mutant huntingtin that was not labeled by an antibody to huntingtin amino acids 342–456. Transfection of cultured cells with mutant huntingtin revealed that an N-terminal huntingtin fragment (amino acids 1–208 plus a 120 glutamine repeat) caused a greater increase in caspase activity than did exon 1 huntingtin and longer huntingtin fragments. These results suggest that context-dependent neurodegeneration in HD may be mediated by different N-terminal huntingtin fragments. In addition, this study has identified neurodegenerative markers for the evaluation of therapeutic treatments in HD mouse models.

Topic: Genetic Neurodegenerative Diseases
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Ghazal I, and: Ghazal II

“Ghazal I”: Traditionally inclined ghazal that is an epithalamium, which uses the Diné word for “one I spend my life with” as the form’s radif. “Ghazal II”: Traditionally inclined ghazal that uses dark subject matter in juxtaposition to natural imagery.

Topic: African history and culture analysis
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
EFFLUENT TREATMENT FACILITY PEROXIDE DESTRUCTION CATALYST TESTING

The 200 Area Effluent Treatment Facility (ETF) main treatment train includes the peroxide destruction module (PDM) where the hydrogen peroxide residual from the upstream ultraviolet light/hydrogen peroxide oxidation unit is destroyed. Removal of the residual peroxide is necessary to protect downstream membranes from the strong oxidizer. The main component of the PDM is two reaction vessels utilizing granular activated carbon (GAC) as the reaction media. The PDM experienced a number of operability problems, including frequent plugging, and has not been utilized since the ETF changed to groundwater as the predominant feed. The unit seemed to be underperforming in regards to peroxide removal during the early periods of operation as well. It is anticipated that a functional PDM will be required for wastewater from the vitrification plant and other future streams. An alternate media or methodology needs to be identified to replace the GAC in the PDMs. This series of bench scale tests is to develop information to support an engineering study on the options for replacement of the existing GAC method for peroxide destruction at the ETF. A number of different catalysts will be compared as well as other potential methods such as strong reducing agents. The testing should lead to general conclusions on the viability of different catalysts and identify candidates for further study and evaluation.

Topic: Water Quality Monitoring and Analysis
Subfield: Industrial and Manufacturing Engineering
Field: Environmental Science
Domain: Physical Sciences
Preliminary results of a phase II trial of gefitinib in progressive metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study

4083 Background: Metastatic NET (including islet cell carcinoma (ICC) and carcinoid tumors) are progressive in nature despite their indolent behavior. Systemic treatment options are limited. Immunohistochemichal (IHC) data suggest these tumors frequently express the epidermal growth factor receptor (EGFR). This suggests that EGFR mediated signaling may contribute to the growth of NET. Gefitinib is a small-molecule inhibitor of the EGFR tyrosine kinase domain. Methods: We evaluated 6 month progression-free survival (PFS) in two separate cohorts (ie, carcinoid and ICC) and using two separate Phase II trial designs. PFS rates at 6 months of 30% (carcinoid) and 10% (ICC) were considered promising. Importantly, objective radiologic progression by RECIST criteria was required for study entry. Other eligibility criteria included: ECOG PS ≤ 2, ≤ 1 prior chemotherapy, and good organ function. Prior or concurrent octreotide and prior interferon were allowed. Results: 37 patients (pts) were enrolled: (22 carcinoid, 15 ICC). There were 16, 20, and 1 patients with PS of 0, 1, and 2 respectively. Median age was 56 yrs (range 36–79). 14 of 22 (64%) pts with carcinoid tumors and 2 of 15 (13%) pts with ICC were progression-free at 6 months. No objective responses have been observed. Grade 3–4 toxicity (i.e. at least possibly related to gefinitib) was observed in 3 carcinoid pts including diarrhea (1), nausea (1), duodenal ulcer (1), anorexia (1), dehydration (1), fatigue (1), and rash (1);and 3 ICC pts including fatigue (1), hyperglycemia (1), and rash (1). IHC markers of the EGFR pathway on tumor tissue will be presented. Conclusion: Gefitinib can produce prolonged disease stabilization in pts with prior documented objective progression of carcinoid tumors and ICC. Further accrual to this multicenter P2C trial is ongoing. Supported by NOI CM17104. No significant financial relationships to disclose.

Topic: Neuroendocrine Tumor Research Advances
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Microbial Cell Factories for Tetrahydroisoquinoline Alkaloid Production

Abstract For decades, plants have represented an inexhaustible source of natural products used in various sectors such as health and industry. However, one recurring problem is the low accumulation of these compounds in planta and, therefore, their production costs and supply. In recent years, unprecedented hope has been brought by the metabolic engineering of microorganisms, which opens up prospects for supply of these molecules at lower cost with high added value. However, many of these productions remained at a laboratory scale. In a recent article published in Nature Communication , Vincent J. J. Martin's team has developed an optimized yeast strain capable of synthesizing not only a huge amount of ( S )‐reticuline, a major precursor of the plant tetrahydroisoquinoline alkaloid series, but also a whole range of new‐to‐nature compounds from this prominent family of natural products. This synthesis, reaching industrial scales, thus paves the way to efficient production in microbial cell factories.

Topic: Plant biochemistry and biosynthesis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
West Nile Virus Trials

The National Institute of Allergy and Infectious Diseases is expanding its clinical trial of an experimental West Nile virus (WNV) treatment. The trial opened at 36 sites last September, and it is expected to add about 24 new sites this summer.

Topic: Mosquito-borne diseases and control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Tachosil® in hepatobiliary surgery - our experience

TachoSil® is a product used in surgical branches of medicine as a supportive therapy. Specifically, this product is used for local support of haemostasis and tissue sealing during surgical treatment where satisfactory results have not been achieved by conventional techniques. We observed the duration of intraoperative hemostasis, compared it with already available results showing the duration of haemostasis in other cases and clearly demonstrated the benefits of TachoSil®. In a sample of ten patients with intraoperative use of TachoSil®, the mean value of haemostasis was 4.2 min (3.2 min-7 min). A leakage of bile into the abdominal drain was observed in only one patient after the administration of TachoSil®. In hepatobiliary surgery, cost/benefit ratio is undoubtedly in favour of TachoSil®. Our results correlate well with those of our colleagues from around the world.

Topic: Gallbladder and Bile Duct Disorders
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
A Behavioral Finance Analysis on ETF Investment Behavior

Since the global financial tsunami, Exchange Traded Funds have attracted much attention, as investors are increasingly concerned with the underlying risk exposure and transparency in their investments. However, much is yet to be learned about its behavioral characteristics, in addition to the traditional risk and return factors. In this paper, we take a behavioral finance perspective to investigate additional behavioral factors during the ETF investment process. We have found some behavioral characteristics, that are unique for the ETF investment and the Hong Kong regions.

Topic: Financial Markets and Investment Strategies
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Green Synthesized Silver Nanoparticles Induced Accumulation of Biomass and Secondary Metabolites in Hairy Roots of Rehmannia glutinosa

The hairy roots of Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. &amp; C. A. Mey. are capable of producing active compounds such as iridoid glycoside, and phenylethanoid glycosides, which have potential applications in the pharmaceutical industry. Silver nanoparticles (AgNPs) have been used as novel elicitors in the induced cultivation of hairy roots, but there is a lack of research regarding their effects on R. glutinosa hairy roots. In the present study, silver nanoparticles (Pp-AgNPs) synthesized by the endophytic fungus Penicillium polandii PG21 were adopted to elicit hairy roots of R. glutinosa, to investigate their influences on the biomass, color, secondary metabolites, antioxidant activity, sucrose metabolism, and phytohormone-related gene expression. The results revealed that the dry weight and fresh weight of R. glutinosa hairy roots were both higher in the treated group than in the control group after addition of 2 mg/L Pp-AgNPs for 20 d. The content of verbascoside, total phenylethanol glycosides and total cycloartenoid in the treatment group reached the highest level at 20 d, which were 1.75, 1.51, 1.44 times more than those in the control group, respectively. Pp-AgNPs significantly stimulated the enzyme activities of catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD). The growth-promoting effect of Pp-AgNPs may be accomplished by increasing sucrose metabolism, and regulating the synthesis and signal transduction of gibberellin (GA) and indoleacetic acid (IAA). Moreover, expressed sequence tags-simple sequence repeat (EST-SSR)-based genetic diversity analyses indicated that there was little possibility of genetic variation among samples under different treatment conditions. In conclusion, the appropriate concentration of Pp-AgNPs can be used as an effective elicitor to improve the biomass and secondary metabolites content in R. glutinosa hairy roots.

Topic: Plant tissue culture and regeneration
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Anastomosis between the left and the right lingual artery].

The aim this study was to investigate the presence of anastomosis between the left and the right lingual artery, as well as their localisation and caliber. Thirty fresh preparations of the tongue, together with the floor of the oral cavity, were investigated. The following methods were used: corrosion, Spalteholz's method, histology (hamatoxylin-eosin and Van Gieson) and radiography of micropaque injected specimens. In each of the three injected specimens (of 30 studied by all these methods) one anastomosis of 0.5 mm in the diameter, was found. Two of the three were between the suprahyoid arteries, and one between the left and the right lingual artery. In all the India ink injected specimens contralateral small vesels were filled. This suggested the presence of capillary or arteriolar anastomoses. The number of these anastomoses gradually decreased in retrocaudal direction (from the apex to the base of the tongue).

Topic: Oral and Maxillofacial Pathology
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Antenatally diagnosed choroidal fissure cysts: a less benign clinical entity?

Poster: RANZCR ASM 2013 / R-0041 / Antenatally diagnosed choroidal fissure cysts: a less benign clinical entity?  by:  A. Rayner , A. M. Fink; Melbourne/AU

Topic: Pregnancy and preeclampsia studies
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Enzymatic Degradation of Polygalacturonic Acid by <i>Yersinia</i> and <i>Klebsiella</i> Species in Relation to Clinical Laboratory Procedures

As scored by several specified plating procedures, clinical and environmental strains of Yersinia enterocolitica, Yersinia pseudotuberculosis , and Klebsiella pneumoniae “Oxytocum” showed detectable, albeit generally weak, ability to digest polygalacturonic (pectic) acid. None of these bacterial strains had the vigorous and rapid pectolytic activity on these polygalacturonic acid-containing media that is typical of soft-rot Erwinia species, although some of the Oxytocum strains came fairly close. Analyses of the pectolytic enzyme contents of the cells and culture supernatants of the Yersinia and Klebsiella species revealed that readily detectable quantities of cell-bound polygalacturonic acid trans -eliminase and hydrolytic polygalacturonase were formed by the Yersinia and Klebsiella species; however, the total units of enzyme activity produced by these bacteria were, in general, lower than were produced by soft-rot Erwinia species. Furthermore, unlike the situation in soft-rot Erwinia cultures, these pectolytic enzymes of Yersinia and Klebsiella species were not excreted rapidly and massively into the growth medium. Cultures of other enterobacteria ( Citrobacter species, Enterobacter species, Erwinia amylovora, Erwinia herbicola, Escherichia coli, Proteus species, Salmonella typhimurium , and Serratia marcescens ) showed no pectolytic ability whatsoever by any of the plating procedures used and (to the extent they were so examined) produced no pectolytic enzymes detectable either in their cells or culture supernatants. This slow or weak release of pectolytic enzymes by Yersinia and Klebsiella species has a bearing on clinical laboratory procedures suitable for detecting their pectolytic activity; methods adequate for this purpose are detailed.

Topic: Probiotics and Fermented Foods
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
MAP READABILITY: EXPERIMENTAL RESEARCH

Previous theoretical research on the characteristics of map readability [see MSRS, 1988, No. 4, pp. 276-283] is tested using several groups of subjects (already familiar with map use) in order to ascertain the most important elements facilitating map readability or detracting from it. The results are modeled through a series of regression equations in an effort to determine the relationships between specific characteristics (number of symbol size classes, frequency of symbols within classes, background complexity) and map readability (speed and accuracy of symbol identification). Translated by Edward Torrey, Alexandria, VA 22308 from: Vestnik Leningradskogo Universiteta, serlya 7 (geologiya, geografiya), 1988, No. 2, pp. 40-46.

Topic: Geographic Information Systems Studies
Subfield: Geography, Planning and Development
Field: Social Sciences
Domain: Social Sciences
The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

C-Circles, self-primed telomeric C-strand templates for rolling circle amplification, are the only known alternative-lengthening-of-telomeres (ALT)-specific molecule. However, little is known about the biology of C-Circles and if they may be clinically useful. Here we show that C-Circles are secreted by ALT+ cancer cells inside exosomes, and that a blood-based C-Circle Assay (CCA) can provide an accurate diagnostic for ALT activity. Extracellular vesicles were isolated by differential centrifugation from the growth media of lung adenocarcinoma, glioblastoma, neuroblastoma, osteosarcoma, and soft tissue sarcoma cell lines, and C-Circles were detected in the exosome fraction from all eleven ALT+ cancer cell lines and not in any extracellular fraction from the eight matching telomerase positive cancer cell lines or the normal fibroblast strain. The existence of C-Circles in ALT+ exosomes was confirmed with exosomes isolated by iodixanol gradient separation and CD81-immunoprecipitation, and C-Circles in the exosomes were protected from nucleases. On average, 0.4% of the total ALT+ intracellular C-Circles were secreted in the exosomes every 24 h. Comparing the serum-based and tumor-based CCAs in 35 high risk neuroblastoma patients divided randomly into ALT+ threshold derivation and validation groups, we found the serum-based CCA to have 100% sensitivity (6/6), 70% specificity (7/10), and 81% concordance (13/16). We conclude that the secretion of C-Circles by ALT+ cancer cells in the exosomes provides a stable blood-based biomarker and a potential clinical diagnostic for ALT activity.

Topic: Extracellular vesicles in disease
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation

&lt;p&gt;Supplementary Table S3. Association of various factors with invasion and metastasis determined by logistic regression.&lt;/p&gt;

Topic: Ubiquitin and proteasome pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Higher education curriculum design for sustainable development: towards a transformative approach

Purpose Education is widely recognized as a key domain for the promotion of the sustainable development goals (SDGs), prompting an increased focus on sustainable development in foreign language education. Despite increased attention, guidelines about SDGs are often primarily policy-based without concrete guidance, and the integration of education for sustainable development (ESD) within higher education curricula has been slow. This paper aims to mitigate this gap by providing an outline for the curriculum development for three elective English courses integrating SDG themes. Design/methodology/approach The paper begins by introducing the SDGs, ESD and its application to language education. From there, this paper outlines three content and language integrated learning courses that integrate global issues into their curriculum. Finally, there is a discussion and consideration of various factors to consider when implementing global issues into an English language classroom. Findings Following practical examples of how to integrate global issues into an English language classroom, considerations such as socio-cultural context, teaching context and the expertise of the instructor are discussed. Originality/value This paper covers a variety of social topics related to sustainable development in addition to the often addressed environmental topics. Many guidelines about integrating SDGs into education are policy-based without concrete guidance, so this paper aims to provide practical examples and considerations.

Topic: Global Education and Multiculturalism
Subfield: Education
Field: Social Sciences
Domain: Social Sciences