jimnoneill/paper-to-field-training huggingface dataset:
Malignant transformation in polyneuropathy associated with monoclonal gammopathy

<b>Objective: </b> To assess the frequency of hematologic malignancies at diagnosis and to determine the incidence and predictors of malignant transformation during follow-up in patients with polyneuropathy associated with monoclonal gammopathy. <b>Methods: </b> Potential predictors of malignant transformation from medical history, hematologic, neurologic, and laboratory examination performed each 6 months were evaluated by univariable and multivariable Cox proportional hazard analysis. <b>Results: </b> Of 193 patients with polyneuropathy associated with monoclonal gammopathy, 17 patients had a hematologic malignancy at diagnosis. The incidence rate of malignant transformation in 176 patients without a malignancy at diagnosis was 2.7/100 patient years. Weight loss, progression of the polyneuropathy, unexplained fever or night sweats, and M-protein level were independent predictors. <b>Conclusions: </b> Since hematologic malignancies occur frequently in polyneuropathy associated with monoclonal gammopathy, the authors suggest that all patients should be screened at diagnosis and subsequently during follow-up if malignant transformation is suspected.

Topic: Peripheral Neuropathies and Disorders
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
2. Does the Letter Matter?

Chapter Two (‘Does the Letter Matter?’), taking the definition ‘boundary, landmark[…]pillar (whether inscribed or not)’ as its starting point, returns to the earliest examples of the horos in the archaeological record. Here I confront the Derridean problem of writing as origin. Even if the stone was not marked with the word for boundary (horos), it does not cease to be a boundary because it was nonetheless read as a boundary. Therefore, I turn to the lexicons to discover how the Greeks themselves defined the horos. The result is twofold, like the boundary; a definition of the word must accept the horos as the boundary of writing and reading. It is always inferred in any act of reading because there must be something, whether the inscribed word or the natural rock, for us to read. Horos proliferates from the rock into our definitions of what words mean, and it always remains as the solid foundation of these works of ‘definition.’ It is the difference and bond that is co-terminal with language as such but does not for all that lose its base materiality as stone.

Topic: Classical Antiquity Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Anemia after kidney transplantation

Background: Anemia is a major cardiovascular riskfactor in renal disease. It might be appropriate toextrapolate this association of anemia with cardiovasculardisease to renal transplant recipients who continue tohave a significant cardiovascular risk.The aim of our study was to elucidate the prevalence andrisk factors of anemia after kidney transplantation.Methods: We studied 118 stable adult kidney transplantrecipients [age at transplant ranged between 22 and 58,42 12], 74 (62.7%) were males and 44 were females(37.3%) who received allograft between December 1998and October 2008 and had at least 1 year of posttransplantfollow up data at Sugar Medical Center,Theodor Bilharz Research Institute (TBRI), and HealthInsurance Organization Cairo. Hemoglobin (Hb) level at6 months, and 1 year after renal transplantation wasrecorded, the eGFR was calculated using the MDRDformula. Risk factors for anemia were evaluated usingunivariate and multivariate regression analysis.Results: Anemia (Hb &lt;12 g/dl in females and &lt;13 g/dl inmales) was common (28.8% at 6 months, 31.4% at 1year). Significant anemia (Hb &lt;11 g/dl in females and&lt;12 g/dl in males) was also common (15.3% at 6 months,16.8% at 1 year). Severe anemia (Hb &lt;10 g/dl in bothgenders) at 6 months post-transplant was less commonaffecting 4 out of 118 (3.4%) patients. At 1 year, 8 out of118 (6.8%) had severe anemia. Univariate andmultivariate analysis showed that a higher serumcreatinine level and lower eGFR were significant riskfactors at 6 months and 1 year post transplant. At 1 year,in addition to higher creatinine level and lower eGFR,female gender and immunosuppressive drugs(azathioprine and sirolimus) also were significant riskfactors.Conclusions: Anemia is common during the first yearafter kidney transplantation. High serum creatinine, loweGFR, female gender and immunosuppressive drugs[azathioprine, sirolimus] are independent risk factors forpost-transplant anemia.

Topic: Hemoglobinopathies and Related Disorders
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Superior Vena Cava Reconstruction Using An Iliocaval Allograft

Successful replacements of the superior vena cava (SVC) using autogenous saphenous or superficial femoral vein or prosthetic grafts have been previously performed, but the use of allograft for treatment of SVC syndrome has not been reported. The patient treated by the authors was a forty-one-year-old woman who presented with severe venous congestion of the head and neck caused by fibrosing mediastinitis. In addition, she had sclerosing cholangitis and chronic liver failure. To treat her SVC syndrome and provide access for fluid and blood transfusion and for possible venovenous bypass, SVC reconstruction was performed concomitant to orthotopic liver transplantation. A left innominate vein-right atrial bypass was inserted using an iliocaval allograft. The patient had an uncomplicated recovery, and at six months after surgery her SVC allograft is widely patent and her transplanted liver is functioning well. The venous allograft is an excellent conduit for those patients who are receiving immunosuppression therapy to avoid rejection of a transplanted organ.

Topic: Transplantation: Methods and Outcomes
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Fermentation of oxidized hexose derivatives by Clostridium acetobutylicum

Clostridium acetobutylicum fermentations are promising for production of commodity chemicals from heterogeneous biomass due to the wide range of substrates the organism can metabolize. Much work has been done to elucidate the pathways for utilization of aldoses, but little is known about metabolism of more oxidized substrates. Two oxidized hexose derivatives, gluconate and galacturonate, are present in low cost feedstocks, and their metabolism will contribute to overall metabolic output of these substrates. A complete metabolic network for glucose, gluconate, and galacturonate utilization was generated using online databases, previous studies, genomic context, and experimental data. Gluconate appears to be metabolized via the Entner-Doudoroff pathway, and is likely dehydrated to 2-keto-3-deoxy-gluconate before phosphorylation to 2-keto-3-deoxy-6-P-gluconate. Galacturonate appears to be processed via the Ashwell pathway, converging on a common metabolite for gluconate and galacturonate metabolism, 2-keto-3-deoxygluconate. As expected, increasingly oxidized substrates resulted in increasingly oxidized products with galacturonate fermentations being nearly homoacetic. Calculations of expected ATP and reducing equivalent yields and experimental data suggested galacturonate fermentations were reductant limited. Galacturonate fermentation was incomplete, which was not due solely to product inhibition or the inability to utilize low concentrations of galacturonate. Removal of H2 and CO2 by agitation resulted in faster growth, higher cell densities, formation of relatively more oxidized products, and higher product yields for cultures grown on glucose or gluconate. In contrast, cells grown on galacturonate showed reduced growth rates upon agitation, which was likely due to loss in reductant in the form of H2. The growth advantage seen on agitated glucose or gluconate cultures could not be solely attributed to improved ATP economics, thereby indicating other factors are also important. The metabolic network presented in this work should facilitate similar reconstructions in other organisms, and provides a further understanding of the pathways involved in metabolism of oxidized feedstocks and carbohydrate mixtures. The nearly homoacetic fermentation during growth on galacturonate indicates further optimization of this and related organisms could provide a route to an effective biologically derived acetic acid production platform. Furthermore, the pathways could be targeted to decrease production of undesirable products during fermentations of heterogeneous biomass.

Topic: Microbial metabolism and enzyme function
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Can Mr Imaging Solve the Mysteries of the Small Bowel?

Small bowel diseases have always been a challenge to diagnose and treat. Despite Conventional enteroclysis, CT enteroclysis, capsule endoscopy and double balloon endoscopy not all pathologies can be diagnosed. MR enteroclysis is an evolving technique that can solve most of the mysteries of the small bowel.

Topic: Gastrointestinal disorders and treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Path planning method based on hierarchical hybrid algorithm

A path planning method based on hierarchical hybrid algorithm was proposed, which is aimed at the path planning features in urban road traffic. The method by analyzing and transforming the traffic restriction combines the ant colony algorithm and genetic algorithm. The ant colony algorithm employed at the bottom calculates simultaneously in a few of subnets for the local optimization, and the genetic algorithm is used in the top for the global optimization, which makes the algorithm converged to the global optimization faster. The simulation results show that this algorithm not only has a strong effect of practical applications, but substantially reduces the number of optimization calculations and improves the performance of the algorithm.

Topic: Robotic Path Planning Algorithms
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
100% Results With H12-821_V1.0 Exam Dumps [2022]

Valid H12-821_V1.0 Exam Dumps [2022] - H12-821_V1.0 PDF Dumps - A Perfect Way to Ace Exam\n\nBecause the planet of HCIP-Datacom-Core Technology V1.0 H12-821_V1.0 exam is growing at an impressive rate that makes it significant for the professionals to take the HCIP certification exam. That is why Finding the Valid H12-821_V1.0 Exam Dumps [2022] might help you in obtaining the HCIP-Datacom-Core Technology V1.0 exam questions in the initially attempt. Passing the H12-821_V1.0 exam questions can help you in getting your career to a new complete level. But these H12-821_V1.0 pdf dumps need to be from a well valid platform like DumpsInsider. The Huawei H12-821_V1.0 dumps pdf questions happen to be marked as the ideal technique to prepare for the H12-821_V1.0 practice test by the Huawei professionals.\n\nUpdated H12-821_V1.0 PDF Dumps Questions &amp; Answers Of DumpsInsider\n\nUpdated H12-821_V1.0 pdf dumps that happen to be made up by keeping in mind the real HCIP-Datacom-Core Technology V1.0 test scenario can play an immense role in your preparation for the Huawei H12-821_V1.0 exam questions preparation. real H12-821_V1.0 exam dumps [2022] give you the freedom to prepare and pass the H12-821_V1.0 test questions in the initially attempt. H12-821_V1.0 dumps pdf questions have the 100% passing guarantee that makes you stress-free. With the H12-821_V1.0 exam dumps [2022] you can get the HCIP certification hassle-free. But the most essential thing is that you will be able to get the perfect analysis of each topic of the HCIP-Datacom-Core Technology V1.0 exam syllabus.\n\nDownload H12-821_V1.0 Free PDF: https://www.dumpsinsider.com/huawei/H12-821_V1.0-test-simulator\n\n \n\nPractice Through Real Huawei H12-821_V1.0 Practice Test\n\nIf you feel the want of acquiring practice for the Huawei H12-821_V1.0 exam questions then you ought to get the Huawei H12-821_V1.0 practice test of the DumpsInsider. The approved H12-821_V1.0 exam dumps [2022] have been made up by the H12-821_V1.0 exam real interface. While preparing from the Huawei H12-821_V1.0 dumps pdf questions you will be like taking the real exam. You can use the H12-821_V1.0 practice test as your self-assessment tool for the HCIP-Datacom-Core Technology V1.0 questions preparation.\n\n90 Days Free Updates on H12 821 V1.0 Dumps PDF Questions\n\nBecause the Huawei H12 821 V1.0 dumps pdf questions contain the updated HCIP-Datacom-Core Technology V1.0 questions. So in order to maintain the standard of the H12-821_V1.0 pdf dumps the DumpsInsider keeps on updating the HCIP-Datacom-Core Technology V1.0 exam questions. You can get the 90 days free updates on the H12-821_V1.0 braindumps questions and answers. You can get the 24/7 customer care service with all the H12 821 V1.0 preparation material. All in all finding the real H12-821_V1.0 exam dumps [2022] are like acquiring the HCIP certification in the very first attempt.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Involvement of head and neck in high voltage injuries: A study from Himalayan valley

Background: With increasing use of electricity in our day-to-day life the incidence of electrical injuries is increasing. Incidence is higher in developing countries where people are less acquainted to proper and safe use of electricity in contrast to developed countries. Objectives: (1) To study the clinical profile of high voltage injuries to the head and neck region (2) To know the reason for the higher incidence of such injuries and find out various preventive measures to reduce such injuries in future (3) To launch an awareness program among the electrical department workers about electrical injuries and their prevention. Materials and Methods: All patients with high voltage electrical injuries to the head and neck region reporting to our center were included in the study. The study was conducted retrospectively from January 2001 to May 2008 and prospectively from June 2008 to December 2010. A total of 54 patients were included in the study. Results: Involvement of head and neck region was seen in 25.35% of high voltage electrical injury victims. The most common age group was 20-30 years with a mean age of 29.13 ± 8.37 years. Incidence was higher in rural population 75.93% compared with urban 24.07%. Incidence was higher in winter months. Electricians comprised 59.26% of victims. The most common mode of injury was touching the live wire directly or indirectly and was seen in 74.07% patients. Average total body surface burn was 16.32 ± 8.13%. An average of 2.91 surgical procedures per patient were performed. Reconstructive procedures were required in 85.18% of patients. Average hospital stay was 26.81 days. Conclusions: High voltage injuries are not uncommon in Kashmir valley and electric department workers are at a greater risk. The incidence of high voltage injuries would not have been so high had the electric workers been properly trained, hazards of high tension lines explained and use of safety equipments made mandatory.

Topic: Burn Injury Management and Outcomes
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
The Relation of Maternal Factors to the Severity of Hyperemesis Gravidarum

Objective: To assess the relation of maternal factors to the severity of hyperemesis gravidarum.Study design: Cross-sectional study.Setting: Mansoura University Hospitals.Patients and Methods: 120 pregnant women with an intrauterine viable singleton pregnancy of less than 16 weeks' gestation complaining of vomiting with pregnancy.Results: 33 (65.34%) patients were primigravida, 36 (30%) patients were nullipara, 33 (27.5%) patients were primipara,, 48 (40%) patients had BMI <18 , 31 (25.83%) patients had past history of hyperemesis gravidarum , 24 (20%) patients had dysmenorrhea, 16 (13.33%) patients had family history of HG. These maternal factors were significantly higher in Severe HG group than moderate HG group (P value<0.05). 20 patients (16.67%) patients were passive smokers and it was insignificantly different between severe and moderate groups. Hospital stay ranged from 7 to 14 days with a mean value 9.09 ±2.13 days in severe group and ranged from 2 to 5 days with a mean value 3.14 ±1.14 days in moderate group. Hospital stay was significantly prolonged in severe group than moderate group (P value<0.05). Termination of pregnancy occurred in 1 (3.13%) patient in severe group and in 0(0%) patients in moderate group. Termination of pregnancy was insignificantly different between both groups (P value>0.05).Conclusions: Frequency of vomiting and PUQE score were significantly higher in age group (16-25 y), BMI group (<18), parity (0 and 1), in patients with past history of HG , dysmenorrhea and family history of HG (P value <0.05). ketonuria was significantly higher in age group (16-25 y), BMI group (<18), parity (0 and 1) and in patients with past history of HG (P value <0.05). Ketonuria was insignificantly different in patients with passive smoking.

Topic: Pregnancy and Medication Impact
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
End-user Empowerment: An Interdisciplinary Perspective

In virtue of fast spreading emerging technologies, considering end-user empowerment (or human empowerment) while developing or adapting technologies gains importance. Even though many different approaches to end-user empowerment have been proposed, it is hardly clear what "end-user (human) empowerment" is and how it is possible to develop "end-user empowering systems". This paper offers an interdisciplinary perspective on how it can be possible to arrive at a synthesized concept of end-user empowerment, in particular regarding the development of Information and Communication Technologies (ICTs). The provided interdisciplinary perspective includes concepts from Computer Science, Information Systems, Cognitive Science, Psychology, Sociology, Science-Technology-Society, Design, System Science and Philosophy. Based on an interdisciplinary literature review, and from an enactivist, pluralist, and constructivist perspective, we argue that the individual end-users and their needs and values, as well as the environment (including socioeconomical contexts, other actors, etc.) and technologies they interact with, continuously co-create the conception of end-user empowerment. Moreover, we propose that perceiving technological development as co-creation, and considering technologies as value-bearers could provide the first steps in the development of conceptual frameworks required for the development of end-user empowering systems.

Topic: Innovative Approaches in Technology and Social Development
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Effect of X-ray Irradiation on Articular Cartilage Mechanical Properties

A load bearing tissue found at the ends of articulating bones, the articular cartilage provides low friction surfaces for efficient movement.Its mechanical properties are determined by the structure and composition of type II collagen, proteoglycans and interstitial fluid.This work investigates the effects of X-ray irradiation, previously shown to affect the biological properties of the articular tissue, on mechanical properties of articular cartilage using polarized light microscope for imaging and compressive modulus test applied to articular cartilage to determine the effects of the ionizing radiation on mechanical properties.According to the test results, the relaxation time is significantly longer in control than X-ray exposed samples, while the force is much higher showing that the X-ray irradiation causes the reduction in the stiffness of articular cartilage.

Topic: Osteoarthritis Treatment and Mechanisms
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
DNA-inspired nanomaterials for enhanced endosomal escape

To realize RNA interference (RNAi) therapeutics, it is necessary to deliver therapeutic RNAs (such as small interfering RNA or siRNA) into cell cytoplasm. A major challenge of RNAi therapeutics is the endosomal entrapment of the delivered siRNA. In this study, we developed a family of delivery vehicles called Janus base nanopieces (NPs). They are rod-shaped nanoparticles formed by bundles of Janus base nanotubes (JBNTs) with RNA cargoes incorporated inside via charge interactions. JBNTs are formed by noncovalent interactions of small molecules consisting of a base component mimicking DNA bases and an amino acid side chain. NPs presented many advantages over conventional delivery materials. NPs efficiently entered cells via macropinocytosis similar to lipid nanoparticles while presenting much better endosomal escape ability than lipid nanoparticles; NPs escaped from endosomes via a “proton sponge” effect similar to cationic polymers while presenting significant lower cytotoxicity compared to polymers and lipids due to their noncovalent structures and DNA-mimicking chemistry. In a proof-of-concept experiment, we have shown that NPs are promising candidates for antiviral delivery applications, which may be used for conditions such as COVID-19 in the future.

Topic: RNA Interference and Gene Delivery
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Oral Candida Carriage and Morphotype Differentiation in Chronic Periodontitis Patients with and without Diabetes in the Indian Sub-Continent

The aim of this study was to assess the oral Candida carriage and morphotype differentiation of Candida species in chronic periodontitis patients, with and without diabetes mellitus. This cross sectional study included 30 subjects in the age range of 40–60 years, who were divided into two groups: 15 chronic periodontitis only (CP) patients, and 15 chronic periodontitis patients with diabetes (CPD). Clinical measurements included plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and fasting blood sugar level (FBS). The unstimulated whole saliva samples were collected for fungal analysis. Candida carriage was analyzed by measuring colony forming units (CFU) following the culture of samples. Qualitative morphotype differentiation of Candida species from yeast to hyphal form was analyzed using Periodic acid-Schiff (PAS) staining. There was no statistically significant difference between CP and CPD groups for the periodontal parameters. However, a significantly higher Candida species CFU count was found in CPD (0.33 ± 0.23) as compared to CP (0.05 ± 0.04) group. This pilot study suggests that the occurrence of Candida species is higher in the saliva of chronic periodontitis patients with diabetes as compared to patients with chronic periodontitis alone.

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences