jimnoneill/paper-to-field-training huggingface dataset:
The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated Diseases

The receptor for advanced glycation end products (RAGE) is a multi-ligand pattern recognition receptor that is highly expressed in lung epithelial cells. It helps alveolar epithelial cells to maintain their morphology and specific architecture. However, in various pathophysiological conditions, pulmonary tissues express a supraphysiological level of RAGE and its ligands including advanced glycation end products, high mobility group box 1 proteins, and S100 proteins. On interaction with RAGE, these ligands stimulate downstream signaling that generates inflammation and oxidative stress leading to asthma, chronic obstructive pulmonary disease, lung cancers, idiopathic pulmonary fibrosis, acute lung injury, pneumonia, bronchopulmonary dysplasia, cystic fibrosis, and sepsis. Thus, pharmacological agents that can either suppress the production of RAGE or block its biological activity would offer promising therapeutic value against pathogenesis of the aforementioned lungassociated diseases. This review presents a comprehensive overview of the recent progress made in defining the functions of RAGE in lung-associated diseases.

Topic: Advanced Glycation End Products research
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Croissance du chômage et développement des théories économiques

Unemployment growth and progress in economic theory. Progress in neo-classic and keynesian theory has led to unemployment analysis as «Job Search» or «Classic and Keynesian unemployment». But the ability of those analyses to understand unemployment growth and continuance in the whole developed world is moderate. Attempts to synthesise classic and keynesian unemployment in an unique process do not take into consideration that, from a macro-economic point of view, wages are both a cost and an income. Explaining unemployment as a result of a process of intensive accumulation leads to very disturbing conclusions: even the end of the crisis will not lead to founding more jobs. So, if unemployment will persist, job rationing scheme matters a good deal. As now, «dual society» is mainly dependant upon official economy and not upon black or informal economy, as often quoted.

Topic: Economic Theory and Policy
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Immunostimulation

The primary objective of this “Glossary of Terms Used in Immunotoxicology” is to give clear definitions for those who contribute to studies relevant to immunotoxicology but are not themselves immunologists. This applies especially to chemists who need to understand the literature of immunology without recourse to a multiplicity of other glossaries or dictionaries. The glossary includes terms related to basic and clinical immunology insofar as they are necessary for a self-contained document, and particularly terms related to diagnosing, measuring, and understanding effects of substances on the immune system. The glossary consists of about 1200 terms as primary alphabetical entries, and Annexes of common abbreviations, examples of chemicals with known effects on the immune system, autoantibodies in autoimmune disease, and therapeutic agents used in autoimmune disease and cancer. The authors hope that among the groups who will find this glossary helpful, in addition to chemists, are toxicologists, pharmacologists, medical practitioners, risk assessors, and regulatory authorities. In particular, it should facilitate the worldwide use of chemistry in relation to occupational and environmental risk assessment.

Topic: Immunotoxicology and immune responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Safety Factor Calculations for High-strength Inclined Belts Based on NDT Signal Analysis

High-strength steel cord and fabric reinforced conveyor belting is widely used in the coal mining industry. Of prime importance to the reliable operation of a coal mining facility is the conveying system. In many cases, the conveyor is the life-line of a mine, and its failure through damaged reinforcement is usually unpredictable. Research has progressed on two fronts aimed at predicting the safety factor of high-strength belting with known damage and defect levels. By coupling non-destructive testing (NDT) signals analysis to the mechanical properties of load sharing in composite materials, it is possible to calculate the effect of damaged reinforcement inside the belt on the belt safety factor. Safety factor calculations presented in this paper have significant value to operators of long overland and slope conveyors, and are of particular importance to the coal mining industry because of the influence of corrosive mine water on the rusting of steel cords inside rubber belting.

Topic: Belt Conveyor Systems Engineering
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
A Cognitive Typology of Religious Actions

Abstract The rapid but disproportionate growth of the cognitive science of religion in some areas, coupled with the desire to meaningfully connect with more traditional, function-inspired classifications, has left the field with an incomplete and sometimes inconsistent typology of religious and related actions. We address this shortcoming by proposing a systematic typology of counterintuitive actions based on their cognitive representational structures. This typology may serve as the framework of a research program that seeks to establish (1) psychologically, whether each class of events receives different cognitive treatment within a given context and similar representation across contexts; and (2) anthropologically, whether the different classes are characterized by different performance frequencies, social functions, and kinds of interpretations, making them useful explanatory and predictive distinctions.

Topic: Religion, Spirituality, and Psychology
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Analytical Subcellular Fractionation of Guinea-pig Myocardium with Special Reference to the Localization of the Adenosine Triphosphatases

Conference Article| October 01 1974 Analytical Subcellular Fractionation of Guinea-pig Myocardium with Special Reference to the Localization of the Adenosine Triphosphatases FREDERICK J. BLOOMFIELD; FREDERICK J. BLOOMFIELD 1Department of Medicine, Royal Postgraduate Midical School, London W12 OHS, U.K. Search for other works by this author on: This Site PubMed Google Scholar T. J. PETERS T. J. PETERS 1Department of Medicine, Royal Postgraduate Midical School, London W12 OHS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (5): 1098–1101. https://doi.org/10.1042/bst0021098 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation FREDERICK J. BLOOMFIELD, T. J. PETERS; Analytical Subcellular Fractionation of Guinea-pig Myocardium with Special Reference to the Localization of the Adenosine Triphosphatases. Biochem Soc Trans 1 October 1974; 2 (5): 1098–1101. doi: https://doi.org/10.1042/bst0021098 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Cardiomyopathy and Myosin Studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Reply on EC1

<strong class="journal-contentHeaderColor">Abstract.</strong> In this paper, we present a custom-designed nuclear magnetic resonance (NMR) platform based on a broadband complementary metalâoxideâsemiconductor (CMOS) NMR-on-a-chip transceiver and a synchronous reference signal generator, which features arbitrary phase control of the excitation pulse in combination with phase-coherent detection at a non-zero intermediate frequency (IF). Moreover, the presented direct digital synthesis (DDS)-based frequency generator enables a digital temperature compensation scheme similar to classical fieldÂ locking without the need for additional hardware. NMR spectroscopy and relaxometry measurements verify the functionality of the proposed frequency reference and temperature compensation scheme as well as the overall state-of-the-art performance of the presented system.

Topic: NMR spectroscopy and applications
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Genome-Wide Identification and Expression Analysis of the TCP Genes in Jatropha curcas L. Reveals Its Roles in Involvement of Leaf Shape

Jatropha curcas var. nigroviensrugosus CV Yang (Jn) exhibits wrinkled leaves and higher flowering and fruiting rates compared to Jatropha curcas L. (Jc). Teosinte branched1/Cincinnata/Proliferating cell factors (TCPs) are known to play crucial roles in plant development and physiological processes. However, it remains unknown whether or not the TCP gene family regulates in leaf development of Jc and Jn. Here, we systematically performed a genome-wide analysis of the Jc TCP family and investigated the differences in the expression of TCP in different leaf morphologies. In total, our results showed that 18 TCP members were identified in the whole genome sequence of Jatropha curcas L.; Jc TCP genes were classified into two categories by phylogenetic tree construction, among which there were 11 members in the Class I subfamily, seven members in the Class Ⅱ subfamily. It was shown that 12 members of Jc TCP genes were located at the seven chromosomes, and proteins belonging to the same TCP group exhibit higher similarity than those from different groups. Furthermore, the expression profiles of 15 TCP genes were discovered at different leaf developmental stages of Jc and Jn. Jc TCP 4, Jc TCP 5, Jc TCP 8, Jc TCP 13, Jc TCP 14, and Jc TCP 16 showed significantly different expressions, and can be used as candidate genes for regulating leaf development. Therefore, the TCP genes play important roles in regulating the leaf development in Jc, and the manipulation of Jc TCP genes can potentially be an important tool used for the genetic improvement of the leaf.

Topic: Plant Molecular Biology Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The difference of two brain states: A simultaneous EEG/fMRI study

Simultaneous EEG/fMRI is a new technique which can record the EEG and fMRI signal currently. By using this new method people expect to obtain both high temporal and spatial resolution of brain activity. Resting state, which is referred to the brain state under no task conditions, has been one of the focuses of the neuroscience research field. Recently researchers have found the resting state is well organized into very complex structure. Several studies using simultaneous EEG/fMRI have demonstrated that there is some relationship between the EEG and fMRI patterns. In our study, we explored the difference between the functional networks of the two brain states under the resting state, which were identified by two prominent EEG rhythms (alpha and theta). The results demonstrated that the default mode network's activity deceased whereas the other resting networks' activity increased when the prominent rhythm shifted from alpha to theta.

Topic: Functional Brain Connectivity Studies
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Effects of Wind Turbine Noise on Male Greater Prairie-Chicken Vocalizations and Chorus

Wind energy facilities are constructed without full knowledge of their effects on birds, and the noise generated by wind turbines is a particular concern. I investigated the effects of wind turbine noise on male Greater Prairie-Chicken (Tympanuchus cupido pinnatus) vocalizations and chorus near Ainsworth, NE, USA in 2013 and 2014. I studied 14 leks located in the area surrounding a 36-turbine wind energy facility. I used two main approaches in this study. First, I recorded Greater Prairie-Chicken boom, cackle, whine, and whoop vocalizations at each of the study leks and measured the duration, sound pressure level, peak frequency, dominant frequency, fundamental frequency, bandwidth and nonlinearities of each vocalization. I used linear models to determine whether the vocalizations at leks near the wind energy facility differed from vocalizations at leks farther away. I found that within 1000 meters of the wind energy facility, boom and whoop sound pressure levels were higher, boom duration was shorter, whine fundamental frequency was higher, and cackle biphonations occurred less often. These differences suggest that male Greater Prairie-Chickens are adjusting aspects of their vocalizations in response to wind turbine noise. In the second approach, I placed audio recorders along transects extending from leks to record the sound of the Greater Prairie-Chicken chorus. I also placed audio recorders at locations in a grid formation overlaid on the wind energy facility. I created models to describe how the chorus and wind turbine noise were affected by covariates. I used the models to predict levels of the chorus and wind turbine noise and assess the potential for wind turbine noise to mask the chorus under specific scenarios. The results suggested that wind turbine noise may have the potential to mask the Greater Prairie-Chicken chorus at 296Hz under these scenarios, but the extent and degree of masking is uncertain. Many factors, including the accuracy of the masking threshold, variation in signal detection, and characteristics of the chorus, may affect the masking assessment.\nAdvisors: Larkin A. Powell and Mary Bomberger Brown

Topic: Animal Vocal Communication and Behavior
Subfield: Developmental Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Pilot Crossover Study of Berberine and its Short-Term Effects on Blood Glucose Levels in Healthy Volunteers

Abstract INTRODUCTION: Different berberine preparations were evaluated for their effectiveness on lowering blood glucose in a pilot, open-label, crossover study conducted in healthy adults. METHODS: Fourteen healthy volunteers of both sexes were recruited, and seven completed all treatments in the study. Study participants ingested one of three berberine preparations containing 500mg of berberine, respectively. A one week wash out period was included between treatments. A control group was included to measure the participants’ baseline response to a 75g glucose solution without any treatment, and the following interventions were administered: berberine powder in hard gelatin capsules, berberine in an oil matrix encapsulated in soft-gelatin capsules, and berberine in LipoMicel® matrix encapsulated in soft-gelatin capsules. Blood glucose concentrations in each participant were monitored from pre-dose baseline, before the capsules were ingested, until up to 3 hours after the capsules were ingested. RESULTS: LipoMicel Berberine treatment led to reduced blood glucose concentrations Area Under Curve (AUC, mean difference: 1.57; 95% CI: 0.021 - 3.12; P = 0.046; Cohen’s d = 1.53) and reduced maximum glucose concentration (Gmax, mean difference: 1.07; 95% CI 0.004 - 2.14; P = 0.049; Cohen’s d = 1.52) compared to the control group when no-treatment was given. No adverse events related to berberine treatments were reported by participants throughout the study period. CONCLUSIONS: LipoMicel Berberine was effective in lowering blood glucose AUC by 12% after two 500mg doses in 7 participants. Berberine in other formulations may require a longer dosing regimen before blood glucose lowering effects can be demonstrated.

Topic: Berberine and alkaloids research
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access “Enhancing Student Success”: Meeting the Unique Needs of University Students with Deaf-Blindness

Abstract: This article discusses particular challenges that students face who are Deaf-blind at university, for whom it is not effective simply to combine strategies that help students who are blind with those that work for students who are Deaf. Innovative ways of working have been developed by a B.A. student with Deaf-blindness collaborating with an academic language and learning (ALL) adviser, leading to marked improvements in the student&amp;apos;s academic work. First, through regular dialog about the content of her assignments, the student extends her understanding of the routines of enquiry in her discipline. Secondly, we have devised a simple, systematic method by which to offer feedback on her written work, which is easily recognizable to someone using a Braille display to read documents exchanged via email. While these methods were developed to meet the particular needs of a student with a dual sensory impairment, it is likely that the first – which draws on Vygotsky&amp;apos;s insights into language learning, and Bakhtin&amp;apos;s notion of social dialects – could also be helpful to students who are Deaf, while the second, by simplifying feedback and revision, could be helpful to students who are blind.

Topic: Hearing Impairment and Communication
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
study on performance of Indian bank

A financial institution is a business that engages in financial transactions such as investing, lending, and depositing money. Almost everyone has regular interactions with financial institutions. All must be done through financial institutions, from depositing money to taking out loans and exchanging currencies. Here's a rundown of some of the most important forms of financial institutions and their positions in financial systems. The banking system is an essential component of any economy's growth, and this sector is critical to the country's modern economic development. Indian bank is a nationalized bank among the public sector banks, and its success has an impact on the country's economy. Economists have expressed a wide range of views on the efficacy of banking systems in fostering economic development by facilitating large amounts of financial assistance. The Indian Bank, a premier bank owned by the Indian government, was established on March 5, 1907 as Indian Bank Limited and began operations on August 15, 1907. Current research papers provide opportunities to know about profitability and performance of Indian Bank from 2008-09 to 2017-2018.

Topic: Banking Sector Performance and Management
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Both Sides of the Counter

Abstract Background The Motor Neurone Disease (MND) Association of Western Australia provides information, education and advocacy for people living with MND. The role and function of the personnel who provide this service has not been described in the literature and is therefore poorly understood by both healthcare professionals and the public. Purpose To describe the role and function of the West Australian Motor Neurone Disease Association (MNDA [WA]) Care Advisors (CAs). Method Ethnographic observation of seven MNDA (WA) CAs in their normal daily setting. Interviews with end users of CA service (people living with MND and their carers). Analysis of the observations and interview transcripts was undertaken to identify themes. Findings The CAs were observed to undertake their supportive role with passion. Clarity around the role and function was ambiguous, even amongst the people in the roles. It is suggested this is due to limited formalised processes and procedures in an organisation that has moved from originally being run by volunteers through to a professional not-for-profit organisation. This in turn led to issues in recruitment and retention, clinical knowledge versus clinical care and demonstrating capabilities against Key Performance Indicators (KPI’s) for reporting to funding bodies. Conclusion Multiple opportunities were highlighted during this study for these service providers to develop robust procedures to record the nature of their work, develop resilience in their work place, and ensure ongoing professional develop processes are engaged.

Topic: Amyotrophic Lateral Sclerosis Research
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
The Impact of Genetic Testing and Genetic Information on Ethical, Legal and Social Issues in North America

This chapter discusses the impact of genetic testing and genetic information. It proposes a framework that facilitates a critical analysis of the ethical, legal, and social issues of genetic testing. The ethical effects include privacy infringement, genetic discrimination, misleading advertisement, psychological impact, and individual autonomy. The legal impacts embrace consistent terminology, referral guidelines, patent wars, and new legislations. The social effects pertain to inequality, higher insurance fees, tax burden, and fear of new eugenics. Information and communication technologies dramatically augment the effect of genetic testing on these outcomes. This chapter argues that information and communication technologies and rapid advances in genetics challenge the existing legislation systems in North America. Therefore, policy-makers need to address the tension between the potential benefits and harms of genetic testing and genetic information.

Topic: Reproductive Health and Technologies
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Comparison of finite-difference time-domain SAR calculations with measurements in a heterogeneous model of man

A finite-difference time-domain technique was used to calculate the specific absorption rate (SAR) at various sites in a heterogeneous block model of man. The block model represented a close approximation to a full-scale heterogeneous phantom model. Both models were comprised of a skeleton, brain, lungs, and muscle. Measurements were conducted in the phantom model using an implantable electric-field probe and a computer-controlled data acquisition system. The calculation and measurement of SAR distributions were compared primarily in the head (including the neck) and chest. To obtain the necessary spatial resolution with the computer model, the head and neck were modeled with approximately 105,000 cells, while 86,000 cells were used to configure the chest. Planewave fields, polarized in the E orientation, were utilized to irradiate the models at an exposure frequency of 350 MHz. Reasonable correlation existed between the calculations and measurements.

Topic: Microwave Imaging and Scattering Analysis
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences