jimnoneill/paper-to-field-training huggingface dataset:
Bioactive secondary metabolites from Australian invertebrates, Indonesian marine sponges, and an Indonesian terrestrial plant

A survey on marine natural products isolated from Indonesian sponges and their associated organisms is presented according to the type of the compounds and their biosynthetic origins. An Australian marine sponge from South East Queensland yielded the highly unsaturated tetracyclic merosesquiterpene puupehenone while the sponge Darwinella sp. which was collected from the same region yielded the diterpene aplysillin. The later compound was fully characterised and its complete NMR spectra were assigned. Aplysillin showed very strong activity against the larval stages of Haemonchus contortus and Trichostrongylus columbriformis. It displayed 100% inhibition of the development of H. contortus at any concentration tested and 100 % inhibition of development of T. colubriformis at concentrations of 100 µg/mL and 10 µg/mL. In addition, two bromotyrosine derivatives 11,19-dideoxyfistularin 3 and aerothionin were isolated from a verongiid sponge collected near Heron Island. The sponge MOOL-29 which was collected in Mooloolaba was found to contain a furanoterpene pallescensone. An imidazole alkaloid clathridine was isolated from the nudibranch Notodoris gardineri collected near Lizard Island, Great Barrier Reef A bioassay guided chemistry study of secondary metabolites from Indonesian sponges collected off Gili Trawangan Island in Lombok has been carried out. A Leucetta-like sponge LS-45 yielded two novel imidazole alkaloids deoxypyronaamidine and isopyronaamidine in addition to the known pyronaamidine. Two aromatic bisabolenes (+)-curcuphenol and (+)-curcudiol together with s-sitosterol were also isolated from the sponge LS-3 (order Halichondrida, family Halichondriidae). Furthermore, a 5ɑ,8ɑ-epidioxysterol was isolated from the sponge LS-4 (order Haploscerida, family Petrosiidae). Structure elucidation of these compounds using ID and 2D NMR analysis was described. All pyronaamidines demonstrated cytotoxic activity against the P388 cell line even at very low concentrations (30-40% inhibition at 1.22 µg/mL) while (+)-curcuphenol and (+)-curcudiol exhibited 99% inhibition with IC50 values of 77.97 and 64.11 µg/mL, respectively. An investigation on the fruit extract from an Indonesian medicinal plant Garcinia picrorhiza collected at the Botanical Garden in Bogor afforded a polyisoprenylated benzophenone guttiferone F. The structure of this compound was studied based on comparison of the NMR spectra and the physical properties with literature data.

Topic: Marine Sponges and Natural Products
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Processes triggered in guanine quadruplexes by direct absorption of <scp>UV</scp> radiation: From fundamental studies toward optoelectronic biosensors

Abstract Guanine quadruplexes (GQs) are four‐stranded DNA/RNA structures exhibiting an important polymorphism. During the past two decades, their study by time‐resolved spectroscopy, from femtoseconds to milliseconds, associated to computational methods, shed light on the primary processes occurring when they absorb UV radiation. Quite recently, their utilization in label‐free and dye‐free biosensors was explored by a few groups. In view of such developments, this review discusses the outcomes of the fundamental studies that could contribute to the design of future optoelectronic biosensors using fluorescence or charge carriers stemming directly from GQs, without mediation of other molecules, as it is the currently the case. It explains how the excited state relaxation influences both the fluorescence intensity and the efficiency of low‐energy photoionization, occurring via a complex mechanism. The corresponding quantum yields, determined with excitation at 266/267 nm, fall in the range of (3.0–9.5) × 10 −4 and (3.2–9.2) × 10 −3 , respectively. These values, significantly higher than the corresponding values found for duplexes, depend strongly on certain structural factors (molecularity, metal cations, peripheral bases, number of tetrads …) which intervene in the relaxation process. Accordingly, these features can be tuned to optimize the desired signal.

Topic: DNA and Nucleic Acid Chemistry
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A New Approach to Identify the Motor Vibration and Noise Dependent on Harmonic and FFT Transform

Study Objective<br/>The vibration measurement is mainly used natural frequency and resonance frequency to predict the magnetic device operation status. These categories are the value of the predicted frequency. There are applicable the smart device induced as the motor, transformer, robot integration platform [1]. This common feature is focused the electric motor device where is made by the electromagnetic silicon steel sheet. This study is used the magnetostrictive variation induced by the electromagnetic silicon steel sheet through the exciting power of the current and magnetic field which is to accelerate the vibration and noise variation. It is caused by the excitation of the core and coil. It can intercept the required characteristic signal, analyze the performance of dynamic magnetostrictive of ESS under DC bias and its complex dynamic anisotropy. The motors running under high-frequency conditions cause noise and vibration due to the interaction between magnetomotive forces (MMF) is concerned.<br/>2. Experiment Results and Discussion<br/>Regarding to the vibration frequency prediction as a multi-type classification problem, it uses the neural network features of deep learning to combine the input signal, as shown in Figure 1. That is classified into different categories. To use an optimized method with feedforward convolutional neural network, it can predict the frequency and analyze the AC and DC vibration frequency of the power motor and the non-fixed periodicity of the mechanical robot arm belong to different spectrum models. The sound pressure level is related to the sound intensity level (SIL). The conversion of voltage signal, current signal, and time domain and frequency domain FFT. As shown in Figure 2, to predict the vibration and sound module by using artificial intelligence method, it is verified the operating system through by measurement, numerical analysis and optimal calculation of NN method to identify the vibration and noise of the motor.

Topic: Olfactory and Sensory Function Studies
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Conceptualizing the place of redundant steelworkers in the class structure

This chapter arises from the attempt to understand the labour market experience of a sample of steelworkers made redundant from the British Steel Corporation's Abbey Works at Port Talbot. The behaviour of redundant workers has to be understood not only in terms of their previous employment and labour market histories, but in terms of the redundancy process itself, which the investigator is rarely there to observe. Employment at the Abbey works reached its peak in 1969 when it employed just under 18,000 workers. Most of the redundants had little experience of the external labour market because they had been existing in a large internal market. There are a number of empirical grounds for attaching considerable importance to social location as a determinant of labour market experience. Networks of relationships are the origin, and their structuration the expression, of the existence of identity groups according to whose normative standards reputation may be judged.

Topic: Migration, Ethnicity, and Economy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Implications of the Withdrawal of the Reservation to the Art.13 (2) (c) of the International Covenant on Economic, Social and Cultural Rights

When Japan ratified the International Covenant on Economic, Social and Cultural Rights (ICESCR) in 1979, it reserved the right not to be bound by “in particular by the progressive introduction of free education” in applying the provision of subparagraph (c) of paragraph 2 of article 13 of ICESCR. Although Japan withdrew the reservation 33 years later, on September 11, 2012, the percentage of household expenditure in the total of public and private expenditure for tertiary education has significantly increased. This situation is a result of government policy, “The beneficiary payment principle”. The Basic Plan for the Promotion of Education, which was approved by the Japanese cabinet on June 14, 2013, did not include increasing public expenditure to the average of OECD countries, despite a recommendation in the draft of the Basic Plan by the Central Education Council. In this article, through researching General Comments of Committee on Economic, Social and Cultural Rights (CESCR) and ICESCR, I argue that the Japanese government is obligated to take steps to fully implement article 13 (2) (c).

Topic: Ombudsman and Human Rights
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Methods of Screening-Purification and Antimicrobial Potentialities of Bacteriocin in Health Care

The conclusion of this review presented the significance of a fundamental framework for planning to understanding the basic requirement needed for fast, cost effective screening and purification of bacteriocins. The summered area of their utilities also helpful to extend the research field of bacteriocin. Thus, this report would be useful not only to scale up the screening and production strategies faster at economical rate, but also provides a platform to extend the research field of bacteriocin in many ways.

Topic: Bacterial Identification and Susceptibility Testing
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
PENGARUH KOMPENSASI, MOTIVASI KERJA, DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PT MORODADI BERKAH JAYA BOYOLALI

This research was used to analyze the effect of compensation, work motivation and work discipline on the employee performance of PT Morodadi Berkah Jaya Boyolali. The total population in this study was 105 employees. The research sample of 83 employees with the sampling technique is proportional cluster random sampling. The technique of collecting data is done by using a questionnaire method. The results of this study indicate that partially or simultaneously compensation, work motivation and work discipline have a significant effect on employee performance.

Topic: Employee Performance and Management
Subfield: Human Factors and Ergonomics
Field: Social Sciences
Domain: Social Sciences
Linked collectors and determiners for: Two new species of Colombian Epigomphus (Odonata: Gomphidae).

Natural history specimen data linked to collectors and determiners held within, "Two new species of Colombian Epigomphus (Odonata: Gomphidae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7fbdd6a3-8010-4616-965d-241515af8423 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7fbdd6a3-8010-4616-965d-241515af8423. Formatted as a Frictionless Data package.

Topic: Freshwater macroinvertebrate diversity and ecology
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. Therefore, other therapeutic modalities, such as stereotactic radiosurgery, have emerged. In the current review, we provide an overview of the historical outcomes achieved for RIMs through radiosurgery and microsurgical resection. Furthermore, we provide a discussion of clinical and radiological parameters that affect the decision-making process with regard to the management of RIMs. We also provide an outline of recent changes in our understanding of RIMs, based on molecular and genetic markers, and how these will change our management perspective. We conclude the review by summarizing some of the current obstacles in the management of RIMs with SRS and how current and future research can address these challenges.

Topic: Meningioma and schwannoma management
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
The Powerless Therapist and the Helpless Borderline: Acceptance, Aloneness, and Dyadic Joining

The encounter between therapist and borderline patient brings with it a humbling experience of powerlessness. The therapist or helping agent must confront her or his own feelings of inability to change anything in the patient's mental or material life. With this comes a corresponding reality that the locus of therapeutic action remains very circumscribed indeed. Many therapists, particularly new ones to the field, may feel overwhelmed by anxiety, grief, guilt, and fear, tempting them to jump precipitously into interpretations or thinly veiled advice-giving—or, alternatively, to deflect emotion with hollow “empathic” mirroring. By actively getting in touch with and using his or her experience of powerlessness, however, the therapist can find a way forward that relies on dyadic joining and a more useful conception of the therapist/patient system (whose dynamics, as we will see, are also increasingly clarified thanks to emergent neuroscience findings). Central aspects of this approach have been present since borderline first appeared in the literature, continuing through more recent contributions, notably those of Marsha Linehan and the Dialectical Behavior Therapy (DBT) school.

Topic: Counseling, Therapy, and Family Dynamics
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Evaluation of Shelf Life of Superchilled Cod (Gadus morhua) Fillets and the Influence of Temperature Fluctuations During Storage on Microbial and Chemical Quality Indicators

ABSTRACT Quality changes of aerobically packed cod fillets stored under superchilling and abusive temperature conditions were characterized by the growth of specific spoilage organisms (SSO) and the production of microbial metabolites measured by an electronic nose along with traditional sensory and chemical analysis (total volatile basic nitrogen [TVB‐N], pH). A new process based on quick contact freezing and cold air blasting was used to achieve superchilling of fillets before chilled (0.5 °C) or superchilled (‐1.5 °C) storage. Photobacterium phosphoreum dominated under temperature abusive conditions coinciding with high levels of TVB‐N and increased electronic nose responses indicating increased levels of alcohols and aldehydes at sensory rejection. Dominating growth of Pseudomonas spp. in 1 batch was associated with the origin, the catching method, and the cooling conditions during processing. The superchilling process followed by superchilled storage (‐1.5 °C) extended the sensory shelf life of the fillets for at least 3 d compared with traditional process, resulting in a total shelf life of 15 d. High content of TVB‐N was observed in superchilled fillets at sensory rejection. P. phosphoreum counts were lower under superchilling conditions (6.0 to 6.8 log colony‐forming units [CFU]/g), compared with the traditionally processed chilled fillets (7.2 log CFU/g). However, H 2 S‐producing bacteria appeared to grow steadily under superchilling conditions reaching counts as high as 7.6 log CFU/g at sensory rejection.

Topic: Meat and Animal Product Quality
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Metabolomic Insights into COVID-19 Severity: A Scoping Review

Background: In 2019, SARS-CoV-2, the novel coronavirus, entered the world scene, presenting a global health crisis with a broad spectrum of clinical manifestations. Recognizing the significance of metabolomics as the omics closest to symptomatology, it has become a useful tool for predicting clinical outcomes. Several metabolomic studies have indicated variations in the metabolome corresponding to different disease severities, highlighting the potential of metabolomics to unravel crucial insights into the pathophysiology of SARS-CoV-2 infection. Methods: The PRISMA guidelines were followed for this scoping review. Three major scientific databases were searched: PubMed, the Directory of Open Access Journals (DOAJ), and BioMed Central, from 2020 to 2024. Initially, 2938 articles were identified and vetted with specific inclusion and exclusion criteria. Of these, 42 articles were retrieved for analysis and summary. Results: Metabolites were identified that were repeatedly noted to change with COVID-19 and its severity. Phenylalanine, glucose, and glutamic acid increased with severity, while tryptophan, proline, and glutamine decreased, highlighting their association with COVID-19 severity. Additionally, pathway analysis revealed that phenylalanine, tyrosine and tryptophan biosynthesis, and arginine biosynthesis were the most significantly impacted pathways in COVID-19 severity. Conclusions: COVID-19 severity is intricately linked to significant metabolic alterations that span amino acid metabolism, energy production, immune response modulation, and redox balance.

Topic: Metabolomics and Mass Spectrometry Studies
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Innovative technology of hip-potherapy in complex treatment of manifestations of dysplastic and dystrophic syndrome in children

The article presents pathomechanical grounding of application of designed method of hippotherapy in treatment of manifestations of dysplastic and dystrophic syndrome with evaluation of remote outcomes of complex treatment in 5 years in 120 children. The basics of therapeutic impact of horse riding lie in natural movements of a horse, helping a rider to organize and systematize his or her movements. Hippotherapy (with performing special correcting exercises) as a method of complex treatment of children with dysplastic and dystrophic syndrome forms the skill of space orienting, improves coordination of movements, strengthens and trains muscles. Together with all that it improves psychoemo-tional state of a patient. This method of treatment of combined pelvis and spine deformity in children in comparison with other known techniques provides expressed therapeutic effect due to simultaneous correction of pelvic and spinal muscles, development of muscular-articular perception and muscular-sensor coordination, and also due to reconstruction and formation of a new movement stereotype.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Analytical and computer dynamic discrete simulation model of the mechanism for the formation of monetary amounts to be paid to the enterprise for the production of rocket and space equipment

The key point of flow process modeling is that it is based on the use of discrete models. In traditional approaches to modeling production processes, time is considered as a continuous quantity. Static models are far from reality, since any production has a cyclical nature, since any product is produced in a finite time. In the modern theory and practice of modeling, mathematical models of economic processes in which time changes discretely are of great importance. The work combines various aspects of management, found a common language and structure in describing various conditions in production, the supply of components, raw materials, materials, as well as research, based on investments in staff training and product quality. The key point of flow process modeling is that it is based on the use of discrete models. In traditional approaches to modeling production processes, time is considered as a continuous quantity. Static models are far from reality, since any production has a cyclical nature, since any product is produced in a finite time. In the modern theory and practice of modeling, mathematical models of economic processes in which time changes discretely are of great importance. The work combines various aspects of management, found a common language and structure in describing various conditions in production, the supply of components, raw materials, materials, as well as research, based on investments in staff training and product quality. This article discusses the actual problems of the formation of flows that characterize the financial results of the company's activities for the production of launch vehicles. It is shown that the main flow parameters characterizing the financial condition of the enterprise are the cash flow to be paid and the cash flow to receive incoming funds for the sale of rocket kits, each of these flows is represented by a discrete simulation equation, the solution of which is carried out using computer models. An equation has been formed to determine the cash flow for the payment of wages to the main production personnel at the enterprise. To assess the magnitude of the effect as the final result of the company's activities, an equation has been formed that allows determining the specific cost of the launch vehicle. At a known price and its unit cost, mathematical and computer models of the profit flow received by the enterprise are formed. The graphs of the trajectories of changes in the flow of profit and the expenditure on wages presented in the work allow us to determine the time of the transition process and its dynamic stability under imposed disturbances in the volume of the order from Roscosmos.

Topic: Economic and Technological Developments in Russia
Subfield: Development
Field: Social Sciences
Domain: Social Sciences