jimnoneill/paper-to-field-training huggingface dataset:
MiRNAs and LncRNAs: Dual Roles in TGF-β Signaling-Regulated Metastasis in Lung Cancer

Lung cancer is one of the most malignant cancers around the world, with high morbidity and mortality. Metastasis is the leading cause of lung cancer deaths and treatment failure. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), two groups of small non-coding RNAs (nc-RNAs), are confirmed to be lung cancer oncogenes or suppressors. Transforming growth factor-β (TGF-β) critically regulates lung cancer metastasis. In this review, we summarize the dual roles of miRNAs and lncRNAs in TGF-β signaling-regulated lung cancer epithelial-mesenchymal transition (EMT), invasion, migration, stemness, and metastasis. In addition, lncRNAs, competing endogenous RNAs (ceRNAs), and circular RNAs (circRNAs) can act as miRNA sponges to suppress miRNAs, thereby mediating TGF-β signaling-regulated lung cancer invasion, migration, and metastasis. Through this review, we hope to cast light on the regulatory mechanisms of miRNAs and lncRNAs in TGF-β signaling-regulated lung cancer metastasis and provide new insights for lung cancer treatment.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Research on MPPT technology based on three-stage variable step size disturbance observation method

Abstract For the traditional disturbance observation method, it is impossible to take into account both tracking speed and steady-state accuracy with a fixed step size, so we change the step size and propose disturbance observation method based on three-stage variable step size. The specific method is to set the basic step size and the slope threshold of the P-V curve, and then scale factors according to the interval segment of the slope value of the working point, so as to realize the dynamic adjustment of the step size. Simulation experiments show that after the algorithm is improved, the tracking speed is faster when the environment changes suddenly; when the environment is stable, the power oscillation is reduced. The above has certain positive significance for improving efficiency of the photovoltaic system.

Topic: Photovoltaic System Optimization Techniques
Subfield: Renewable Energy, Sustainability and the Environment
Field: Energy
Domain: Physical Sciences
ADAPTIVE FM SYNTHESIS

This article describes an adaptive synthesis technique based on frequency (phase) modulation of arbitrary input signals. The background and motivation for the development of the technique, as well as related work, are discussed. A detailed description of delay line-based phase modulation of sinusoidal and complex signals is provided. The basic design of an implementation of the technique is presented and commented. A series of examples using four different instrumental sources are discussed. The results show a wide range of possible effects through the use of the technique, from addition of higher components, to changes in the odd-even harmonic balance and the introduction of controlled inharmonicity. 1.

Topic: Advanced Adaptive Filtering Techniques
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Implementation of Total Productive Maintenance Approach: Improving Overall Equipment Efficiency of a Metal Industry

Quality has become one of the most crucial criteria in an institution’s success and survival as there is nothing more than what an era of globalization and intensity demands. Successful businesses recognize that consumer reliability may have a severe influence on their bottom lines. As a result, several competitive companies are constantly raising their quality requirements. Competitive companies think that improving quality is the best way to recover, and most authors have specified various procedures relevant to their processes. The majority of automobile assembly sectors are looking for high-quality requirements in their manufacturing techniques and are executing a quality system known as total productive maintenance (TPM). The study’s goal is to deploy the TPM program inside the metal forming industry to improve metal industry workstations. The overall equipment effectiveness (OEE) for various workstations such as rolling, bending, cutting, and die punching for the fiscal year 2018–2019 has been evaluated. In addition to the other reasons, inefficient resource utilization is a significant component that diminishes the factory’s OEE. In the financial year 2019–2020, the TPM approach was adopted in the enterprise. As a result, there has been an improvement in overall performance.

Topic: Management and Optimization Techniques
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
[The traumatized therapist. Countertransference in a difficult patient].

Anhand der Supervision eines Erstinterviews, in dem der Therapeut in einem komplizierten und traumatischen Gegenubertragungskonflikt das Gefuhl der Rollenumkehr zwischen sich und seinem Patienten entwickelt, rekapitulieren die Autoren die seit Freud kontroverse Diskussion der Gegenubertragung. Dabei machen sie angesichts der Frage, ob Gegenubertragung den therapeutischen Prozes stort bzw. fordert, darauf aufmerksam, das bestimmte Formen der Gegenubertragung hypnoseahnliche Zuge annehmen konnen und die therapeutische Ich-Spaltung auflosen. Dieses Phanomen der »Ubertragungshypnose« sei, so wird gefolgert, wahrscheinlich auch bei einfacheren Formen von Gegenubertragungskonflikten anzutreffen und blockiere dort unerkannt den therapeutischen Prozes.

Topic: Psychoanalysis and Social Critique
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
THE REGULATION OF CARE ACT 2013 APPOINTMENT OF THE MEMBERS OF THE CARE SERVICES TRIBUNAL PANEL

In exercise of the power conferred on it by section 143 of the Regulation of Care Act 2013 and section 4 of the Tribunals Act 2006, the Appointments Commission hereby appoints the following as members of a panel from which the members of the Care Services Tribunal are drawn for a period of three years from the date hereof.

Topic: Healthcare innovation and challenges
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
An Electromagnetic Micro Power Generator Based on Mechanical Frequency Up-Conversion

This paper presents a novel inertial electromagnetic micro power generator. The proposed generator utilizes mechanical frequency up-conversion technique to improve the level of power generated in low environmental frequencies in order to make device more efficient. Power transduction is done by means of electromagnetic induction. The generator's structure consists of two main parts; first part contains of a planar spring with two magnets and a mechanical barrier placed between magnets to up-convert external frequency, and second part is made from four cantilever beams with copper coil deposited on them. The simulation results show 67.4mV and 46.6µW RMS voltage and average power respectively from a single beam by up-converting 75Hz external frequency to 5.9kHz. The total power density gained from four beams is 145.6µW/cm 3 with device internal volume of 0.64cm 3 . 

Topic: Innovative Energy Harvesting Technologies
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Effects of Interior Design of Hotel Rooms on Perceptual and Behavioral Performance of Its’ Users

In this research, interior design quality of classical type hotel rooms has been evaluated regarding the role furniture and decoration play on the perception of space. As part of the research, typical rooms of two five stars hotels from Ankara were included in the research. Each situation was tested by using atmospheric attributes through the use of bipolar adjective pairs on a 1-9 semantic differential scale. Even though the classical type hotel room in each hotel had similar shape, one was a little bit smaller than the other. According to the results the smaller room was the most liked one due to its furniture and decoration. Besides the effect of gender and age on perceptual performance appraisal task was also examined. Compared to middle age group, young users, and compared to female users, male users perceived the space more positively which is important in terms of the statistical evaluation

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Developmental and behavioural characteristics of cri du chat syndrome.

Developmental and behavioural characteristics were assessed in 27 children with cri du chat syndrome using the Society for the Study of Behavioural Phenotypes questionnaire, which gave information on prenatal and perinatal conditions, neurological problems, and developmental and behavioural difficulties. The findings suggest that the behavioural profile of children with cri du chat syndrome incorporates self injurious behaviour, repetitive movements, hypersensitivity to sound, clumsiness, and obsessive attachments to objects. In terms of a developmental profile, children with cri du chat syndrome were able to communicate their needs, socially interact with others, and have some degree of mobility.

Topic: Family and Disability Support Research
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Generating compressed broadband terahertz pulses using aperiodically poled electro-optic crystals

We introduce a general technique to generate compressed broadband terahertz pulses based on difference frequency generation of optical pump radiation using aperiodically poled structures. The pump pulse format and poling of the crystals conceived are such that the emergent terahertz pulse is compressed. The approach circumvents pump pulse distortions that result from non-collinear approaches and the need for external compression. It is particularly efficient for the generation of pulses of intermediate durations of few to tens of cycles. For instance, conversion efficiencies in the few percent range are attainable in cryogenically cooled lithium niobate.

Topic: Terahertz technology and applications
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
MIF as a Disease Target: ISO-1 as a Proof-of-Concept Therapeutic

Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that has been implicated as playing a causative role in many disease states, including sepsis, pneumonia, diabetes, rheumatoid arthritis, inflammatory bowel disease, psoriasis and cancer. To inhibit the enzymatic and biologic activities of MIF, we and others have developed small-molecule MIF inhibitors. Most MIF inhibitors bind within the hydrophobic pocket that contains highly conserved amino acids known to be essential for MIF's proinflammatory activity. The best characterized of these small-molecule MIF inhibitors, (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) has been validated in scores of laboratories worldwide. Like neutralizing anti-MIF antibodies, ISO-1 significantly improves survival and reduces disease progression and/or severity in multiple murine models where MIF is implicated. This MIF inhibitor, its derivatives and other MIF-targeted compounds show great promise for future testing in disease states where increased MIF activity has been discovered.

Topic: Macrophage Migration Inhibitory Factor
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Importance of Monoclonal Gammopathy of Undetermined Significance (MGUS) Surveillance and Difficulty in Diagnosing Monoclonal Gammopathy of Renal Significance (MGRS) in Low-Grade Lymphomas

Abid, Sidrah; Hongalgi, Krishnakumar D.; Beers, Kelly H.; Mehta, Swati Author Information

Topic: CNS Lymphoma Diagnosis and Treatment
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
The impacts of the removable partial dentures on the periodontal statuses of the type II diabetic patients′ abutments

Objective To study the impacts of the removable partial dentures on the periodontal statuses of the typeⅡ diabetic patients′ abutments.Methods Sixty type Ⅱ diabetic patients were selected randomly in the dental clinic.After the non-surgical periodontal treatment,removable partial dentures were restored.Five indices,including plaque index(PLI),gingival index(GI),bleeding index(BI),probing depth(PD) and attachment loss(AL) were compared between the abutments and the counterpart teeth on the opposite side at different time points,including before the restoration and 2 weeks,3 months,6 months,12 months,24 months after the restoration.Results 1) The periodontal indices of the abutments of the type Ⅱ diabetic patients were significantly higher than those of their counterparts(P0.01);2) Indices of PLI,GI,BI,PD and AL of the abutments of the type Ⅱ diabetic patients elevated within 6 months after the restoration(P0.01).However,the periodontal condition tended to be stabilized and relieved as the usage time of the dentures extended further.Conclusions The removable partial denture restoration leads to the increase of the periodontal indices of the abutments of the type Ⅱ diabetic patients.

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Scottish chamber music

Scottish chamber music David Johnson, Musica Scotica, III ( Glasgow University of Glasgow Music Department Publications, 2000), £35 Claire Nelson Claire Nelson Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume XXIX, Issue 3, August 2001, Pages 461–463, https://doi.org/10.1093/earlyj/XXIX.3.461 Published: 01 August 2001

Topic: Scottish History and National Identity
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
Institutions by the Wayside

Abstract Chapter 5 describes Germany’s robust institutions for protecting workers from dismissal, but shows that they are insufficient to protect tech workers from mass layoffs. Just as at IBM San Jose, management at Infineon established market fundamentalism as hegemonic, which complicated workers’ ability to mobilize against layoffs. The chapter traces three collective responses to layoffs at Infineon, led by the works council, the union IG Metall, and by a group of workers who mobilized as shareholders. In each of these responses, organizers developed some of the tactics necessary for building power, but each fell short in a different way. The result was that workers at Infineon were just as precarious as workers in the United States, despite Germany’s formally robust institutions.

Topic: Political Economy and Marxism
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Serum cytokine levels in patients with acute alcohol heart pathology

Aim. To investigate cardiohemodynamic parameters and serum cytokine levels in patients with severe alcohol intoxication (AI). Material and methods. In total, 100 patients with severe AI were examined. All participants underwent 24-hour electrocardiogram (ECG) monitoring, echocardiography (EchoCG), and measurement of serum pro-inflammatory cytokine levels . Results. In patients with severe AI, acute alcohol heart damage (AAHD) was diagnosed relatively often (31.4%). Among these individuals, EchoCG disturbances and increase in serum cytokine levels were maximal. Conclusion. In patients with AAHD, complicated by fatal arrhythmias, pro-inflammatory cytokine synthesis was increased, comparing to arrhythmia-free patients. Maximal cytokine concentration was registered in patients with systolic and/or diastolic left ventricular dysfunction.

Topic: Alcohol Consumption and Health Effects
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
The original technique of the collection and adaptation different types of diagnostic information for congenital urinary malformations in newborns for the systems of automated analysis of three-dimensional images and surgical navigation

The article describes the processes of collecting and adapting the diagnostic information necessary for use in automated analysis of three-dimensional images and surgical navigation. The work is carried out on the basis of the NMRC Obstetrics, Gynecology And Perinatology named after V.I. Kulakov of the Ministry of Health of the Russian Federation with the financial support of the Ministry of Science and Education of the Russian Federation (Agreement dated 03.10.2016 No. 14.607.21.0162, unique identifier RFMEFI60716X0162) The work is devoted to the features of collection, segmentation and description of the results of preoperative radiological diagnostics of newborn patients with congenital urinary malformations such as hydronephrosis (HN), renal duplication with uretherohydronephrosis of the nonfunctional segment (UHN) or multicystic dysplastic kidney (MC). The goal of the work is the development of standards for the collection, classification and segmentation of various diagnostic information of congenital urinary malformations in newborns necessary to use in automated three-dimensional image analysis and surgical navigation. In order to expand the scope of application, it was decided to supplement the data bank with information from the patient's phenotypic chart, compiled by the clinical geneticist when examining the patient. According to the developed and implemented algorithms we collected and segmented 978 series of images belonging to 393 patients with urinary malformations and 452 series of normal urinary system. Available text descriptions of the series are reconstructed to the original developed standard. At present, using this data bank, a subsystem of neural network analysis and reconstruction of diagnostic images of newborn patients is being developed, as well as a surgical navigation system for performing endoscopic surgical manipulations on patients for congenital malformations of the urinal system.

Topic: Pediatric Urology and Nephrology Studies
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Utilizing the mixer method for content management

Content management is a confusing term used in several contexts. We define content management as the organizing of information (for a specific purpose) available in a system. We present the mixer method that uses servlet technology and the model-view-controller design pattern as a way to accomplish content management in a system. The heart of the mixer method is mixer which is a novel helper tool based on a template engine design philosophy. In order to validate our method we show how to solve the problem of separating Java code and HTML code in servlet programming. In our opinion the existing solutions are either too complex or not complete. The mixer method elegantly decouples the data access code, business logic code, and data presentation. Our work shows that the mixer method is easy to learn and to use. We have tested and used the mixer method successfully in large university courses dealing with content management and HTTP server side programming.

Topic: Software Engineering and Design Patterns
Subfield: Development
Field: Social Sciences
Domain: Social Sciences
Evaluating Native Bacillus Strains as Potential Biocontrol Agents against Tea Anthracnose Caused by Colletotrichum fructicola

Anthracnose of the tea plant (Camellia sinensis), caused by Colletotrichum spp., poses a significant threat to both the yield and quality of tea production. To address this challenge, researchers have looked to the application of endophytic bacteria as a natural alternative to the use chemical pesticides, offering potential for enhancing disease resistance and abiotic stress tolerance in tea plants. This study focused on identifying effective microbial agents to combat tea anthracnose caused by Colletotrichum fructicola. A total of 38 Bacillus-like strains were isolated from the tea rhizosphere, with 8 isolates showing substantial inhibitory effects against the mycelial growth of C. fructicola, achieving an average inhibition rate of 60.68%. Among these, strain T3 was particularly effective, with a 69.86% inhibition rate. Through morphological, physiological, and biochemical characterization, along with 16S rRNA gene phylogenetics analysis, these strains were identified as B. inaquosorum (T1 and T2), B. tequilensis (T3, T5, T7, T8, and T19), and B. spizizenii (T6). Biological and molecular assays confirmed that these strains could induce the expression of genes associated with antimicrobial compounds like iturin, fengycin, subtilosin, and alkaline protease, which effectively reduced the disease index of tea anthracnose and enhanced tea plant growth. In conclusion, this study demonstrates that B. inaquosorum, B. tequilensis, and B. spizizenii strains are promising biocontrol agents for managing tea anthracnose.

Topic: Plant Pathogens and Fungal Diseases
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Long‐term follow‐up of Norwegian horses affected with acquired equine polyneuropathy

Summary Background Acquired equine polyneuropathy ( AEP ), a neurological disease clinically characterised by knuckling of metatarsophalangeal joints, has been described in numerous Nordic horses during the last 20 years. Although clinical recovery has been reported, large‐scale data on long‐term follow‐up of survivors have been lacking. Objectives To describe long‐term survival of AEP affected horses registered in Norway, with a focus on athletic performance and possible residual clinical signs connected to the disease. Study design A retrospective cohort study. Methods The study includes 143 horses recorded with AEP in Norway from 2000 to 2012, with the follow‐up period continuing until 2015. Participating owners of survivors completed a standardised questionnaire, providing information on disease and convalescence, management, performance‐level and possible residual clinical signs. To investigate the follow‐up of survivors, we performed 2 multivariable linear regression models. Results The follow‐up time of survivors was 1.0–14.5 years (median 5.3, interquartile range 2.5–7.2). Fifty‐seven horses survived and all but 3 horses returned to previous or higher level of performance. However, possible disease‐related residual clinical signs were reported in 14/57 horses. Forty‐nine of the survivors were in athletic use at time of contact. The majority of survivors were categorised with low severity‐grades at time of diagnosis and the initial grade was significantly associated with time to resumed training. Only 3 horses had experienced relapse/new attack during the follow‐up period. Main limitation Athletic performance was judged by owners, which renders a possible source of bias. Conclusions Although AEP is a potential fatal disease, most survivors will recover and return to minimum previous level of athletic performance. Some horses display residual clinical signs, but often without negative effect on performance and relapse of disease is rare.

Topic: Veterinary Equine Medical Research
Subfield: Equine
Field: Veterinary
Domain: Health Sciences