jimnoneill/paper-to-field-training huggingface dataset:
Subconjunctival adalimumab for treatment of dry eye disease in Sjögren’s syndrome

ABSTRACT Objective To describe the use of subconjuctival administration of the anti-tumor necrosis factor agent adalimumab for treatment of dry eye in patients with Sjögren’s syndrome, and to investigate conjunctival healing. Methods Prospective, nonrandomized, noncomparative interventional case series including consecutive patients with Sjögren’s syndrome and dry eye disease treated with subconjunctival adalimumab, who were refractory to conventional treatment. Patients with infectious ocular surface involvement or structural changes in the tear pathway or eyelids were excluded. Data recorded included age, sex, lissamine green staining pattern, Schirmer test results, intraocular pressure, conjunctival mobility, tear break up time and findings of biomicroscopic evaluation, following fluorescein dye instillation. The Ocular Surface Disease Index questionnaire validated for the Portuguese language was used for subjective assessment of patients. Results Eleven eyes of eight patients were studied. Mean patient age was 53±13.4 years. Patients were treated with subconjunctival injection of 0.03 mL of adalimumab and followed for 90 days thereafter. There were no statistically significant objective improvement (objective tests results; p&gt;0.05) and no statistically significant changes in intraocular pressure (p=0.11). Questionnaire responses revealed a significant improvement in ocular symptoms (p=0.002). Conclusion Based on the Ocular Surface Disease Index questionnaire, subconjunctival administration of adalimumab improved dry eye symptoms. However, objective assessments failed to reveal statistically significant improvements.

Topic: Ocular Surface and Contact Lens
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Ankle brachial index (ABI) in a cohort of older women in the Philippines: Prevalence of peripheral artery disease and predictors of ABI

Abstract Objective Cardiovascular disease (CVD) is rising in low and middle‐income countries, but studies of CVD epidemiology in such settings often focus on risk factors rather than measures of disease progression. Here we use the ankle brachial index (ABI) to assess the prevalence of peripheral artery disease (PAD) among older women living in Metropolitan Cebu, Philippines, and relationships between ABI and CVD risk factors and body composition. Methods ABI was measured using the Doppler technique in 538 female participants in the 2015 Cebu Longitudinal Health and Nutrition Survey (mean age 58 years, range 47‐78 years). ABI was related to a panel of CVD risk factors measured in 2005 and 2012, and to 2012 body composition measures. Results The prevalence of PAD (1.8%) was among the lowest reported in any comparably‐aged sample, and only 9.9% of participants had an ABI indicating borderline PAD risk. Smoking ( P &lt; 0.011) and use of CVD medications ( P &lt; 0.0001) predicted lower ABI (indicating higher PAD risk), which was also lower in relation to 2012 systolic blood pressure ( P &lt; 0.054). ABI was unrelated to other CVD risk factors. An apparent protective relationship between body mass index (BMI) and ABI, noted in previous studies, was found to be confounded by protective relationships between ABI and fat free mass, height, and grip strength (all P &lt; 0.05). Conclusions The prevalence of PAD is low in Cebu Longitudinal Health and Nutrition Survey participants, and ABI was related to few CVD risk factors. Past reports of lower PAD risk in relation to BMI may reflect confounding by lean mass, which has protective relationships with ABI.

Topic: Peripheral Artery Disease Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Supplementary Table S3 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in &lt;i&gt;FLT3&lt;/i&gt;-Mutant Leukemia

&lt;p&gt;Table S3: Clinical characteristics of samples from patients with AML used in PDX assays&lt;/p&gt;

Topic: Cancer, Lipids, and Metabolism
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SIJUNZI DECOCTION DEMOLITION PARTIES INHIBIT PROLIFERATION AND INDUCE APOPTOSIS OF HUMAN GASTRIC CANCER BGC823 SIDE POPULATION

Background: Comprehensive treatment combining with Chinese medicine has become the main therapeutic regimen of gastric cancer. Previous&#x0D; evidence demonstrated SD can enhance the effect of chemotherapy in advanced cancer, especially in gastric cancer. In order to investigate the&#x0D; anticancer mechanism of SD in gastric cancer, we observed the effects of SD parties (Ginseng, Atractylodes, Poria, Licorice) on proliferation and&#x0D; apoptosis of SP of human gastric cancer BGC-823.&#x0D; Materials and Methods: 1. BGC-823 side population cells were sorted through flow cytometry. 2. To detect the changes of proliferation of SP&#x0D; and NSP before and after the intervention of serum containing SD parties using cck-8 method. 3. To detect the changes of cell cycle and&#x0D; apoptosis of SP and NSP before and after the intervention of serum containing SD parties through flow cytometry. 4. To detect the effects of&#x0D; serum containing SD parties on apoptosis-related proteins Bax and Bcl-2 of SP and NSP before and after the intervention by western-blot.&#x0D; Results: It was found that four demolition parties serum treatments inhibited cell proliferation in a time-dependent manner. Compared with the&#x0D; control group (normal saline treatment), there were increase in G1/G0 phase population of SP and NSP, and decrease in G2/M and S phase&#x0D; population (P

Topic: Ginseng Biological Effects and Applications
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Obstrução uretral recorrente em felino

The goal of this project is to improve the knowledge of veterinarians and students by registering data and emphasizing information that will help identify common factors associated with Feline Lower Urinary Tract Disease (FLUTD). Clinical signs associated with the feline lower urinary tract are a frequent reason for veterinary appointments, presenting dysuria, hematuria, pollakiuria, periuria and stranguria. The etiology of FLUTD is multifaceted and can include urolithiasis, urethral obstruction, urinary tract infections, neoplasia, trauma, urinary incontinence, neurogenic causes, behavioral factors, and/or feline idiopathic cystitis. For recurring cases, a urethrostomy followed by a penectomy, along with environmental changes, are recommended to promote improved well-being.

Topic: Veterinary Medicine and Surgery
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice

In vitro, the transcription factor sterol regulatory element binding protein-1c (SREBP-1c) mimics the positive effects of insulin on hepatic genes involved in glucose utilization, such as glucokinase (GK) and enzymes of the lipogenic pathway, suggesting that it is a key factor in the control of hepatic glucose metabolism. Decreased glucose utilization and increased glucose production by the liver play an important role in the development of the hyperglycemia in diabetic states. We thus reasoned that if SREBP-1c is indeed a mediator of hepatic insulin action, a hepatic targeted overexpression of SREBP-1c should greatly improve glucose homeostasis in diabetic mice. This was achieved by injecting streptozotocin-induced diabetic mice with a recombinant adenovirus containing the cDNA of the mature, transcriptionally active form of SREBP-1c. We show here that overexpressing SREBP-1c specifically in the liver of diabetic mice induces GK and lipogenic enzyme gene expression and represses the expression of phosphoenolpyruvate carboxykinase, a key enzyme of the gluconeogenic pathway. This in turn increases glycogen and triglyceride hepatic content and leads to a marked decrease in hyperglycemia in diabetic mice. We conclude that SREBP-1c has a major role in vivo in the long-term control of glucose homeostasis by insulin.

Topic: Cholesterol and Lipid Metabolism
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Forms of Work in Interactive Teaching of Mathematics

In accordance with modern teaching methods mathematics, the degree of interactivity of teaching/learning is a basic criterion the quality of the basic mathematics education process. Methodical approach to interactive continues, for each class separately, contains original methodological frameworks with models of interactive processing of all teaching units. Interactive teaching is a social process, learning as an interaction between students and teachers, students, students and parents, peers. The result of this teaching are relatively permanent changes in thinking and behavior, which occur based on experience, tradition and practice achieved in social interaction.

Topic: Educational Methods and Teacher Development
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Investigations of UV-crosslinkable water-soluble acrylic pressure-sensitive adhesives

Titled adhesives based on acrylic acid (AA) or b-acryloyloxy propionic acid (APA) and butyl acrylate (BA) were synthesized. Unsaturated photoinitiators were introduced into their chains, namely: 4-acryloyloxy benzophenone (ABP), 2-hydroxy-1-[4-(2-acryloyloxy-ethoxy) phenyl]-2-methyl-1-propanone (ZLI 3331) or phenyl-1(1-acryloyloxy)-cyclohexyl ketone (PAC). These products were plastified with polyoxyethylene glycols (PEG) differing in molecular weight (400 - 1010 Da) or polyoxypropylene glycols (PPG). The effects of chemical compositions of comonomers, plasticizer types and contents as well as effect of pH on the following basing properties of obtained aqueous adhesive systems (PSA) were investigated: water solubility, cohesion and adhesion. Dependence of water solubility of selected plasticized PSAs on UV curing time was also determined. PSA based on 70 wt. % of AA and 30 wt.% of BA with addition of 0.5 wt. % of ABP as photoinitiator/comonomer, plastified with 60-120 phr of PPG has been found as optimal.

Topic: Photopolymerization techniques and applications
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
1948–1954, now ages 56–62), Late Boomers (born between 1955–1964, now ages 46–55), and Generation Xers (born

between 1965–1974, now ages 36–45). This article reports these 2010 Retirement Savings Shortfalls (RSS). NATIONAL RETIREMENT SHORTFALL: $4.55 TRILLION: The aggregate RSS for these age cohorts expressed in 2010 dollars is $4.55 trillion, for an overall average of $47,732 per individual. The average RSS varies by age cohort as well as gender and marital status. The RSS per individual is always lowest for households, somewhat higher for single males, and more than twice as large for single females. The estimated retirement shortfall for any gender/marital status combination increases for younger cohorts, largely due to the impact of health care-related costs rising faster than the general inflation rate. NURSING HOME AND HOME HEALTH CARE: Adding nursing home and home health care expense increases the average individual RSS for married households by $25,317. Single males experience an average increase of $32,433, while single females have an increase of $46,425. The Impact of the COBRA Premium Subsidy on Coverage ARRA AND THE COBRA SUBSIDY: The American Recovery and Reinvestment Act of 2009 included a provision for the federal government to pay 65 percent of the premium for individuals who were covered under COBRA and who incurred an involuntary job loss between Sept. 1, 2008, and Dec. 31, 2009. The subsidy was made available for up to nine months, and was extended by Congress three times, with the last extension occurring in April 2010. This article

Topic: Financial Literacy, Pension, Retirement Analysis
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
NEWSCRIPTS

RETURN TO ISSUEPREVNewsNEXTNEWSCRIPTSCite this: Chem. Eng. News 2004, 82, 25, 56Publication Date (Print):June 21, 2004Publication History Published online14 November 2010Published inissue 21 June 2004https://doi.org/10.1021/cen-v082n025.p056Copyright © 2004 American Chemical SocietyArticle Views11Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (563 KB) SUBJECTS:Equation of state,Redox reactions Get e-Alerts

Topic: History and advancements in chemistry
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Morning versus evening induction of labour for improving outcomes

Taking into account women's preferences that favoured administration of prostaglandins in the morning, we conclude that caregivers should preferably consider administering prostaglandins in the morning.There is no strong evidence that induction of labour with intravenous oxytocin in the evening is more or less effective than induction in the morning. Consideration may be given to start induction of labour with oxytocin in the evening when indicated.

Topic: Maternal and Perinatal Health Interventions
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
MAGBONS: Novel Magnetically Separable Carbonaceous Nanohybrids from Porous Polysaccharides

Abstract Novel magnetically separable carbonaceous nanohybrids were prepared from porous starch by a direct multistep incorporation method. Materials denoted as MAGBON possessed an unprecedented magnetism at 450 °C and a somewhat similar structure to that of Starbon materials, with a contribution of CC, CO, and aromatic groups. Simple sulfonation of MAGBON450 provided access to sulfonated MAGBON materials with promising catalytic activities as shown in microwave‐assisted oxidations of benzyl alcohol and xylose dehydration to furfural.

Topic: Mesoporous Materials and Catalysis
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
LES DÉBATS SUR LE PARTAGE DE LA TAXE SCOLAIRE À MONTRÉAL

In 1869, the provincial government of P.-J.-O. Chauveau established a school tax in Montreal. This tax was deducted from land properties, and income was divided between the Catholic and Protestant school boards with regard to the landowners’ religion. Generally wealthier than the Catholics, Protestants were favoured by this mode of distribution of the school tax. This article attempts to explain the causes of the adoption and continuation of this mode of financing during more than a century by examining the major debates about the distribution of the school tax at the end of the 19th century. The study concludes that the continuation of this mode of financing is not devoid of ideological foundations strongly connected to the educational concept of the Catholic and Protestant elite and their respective visions of interethnic relations.*&#x0D; &#x0D; * La traduction du résumé est de Gabriel Saint-Jean, sous la supervision de sa professeure d’anglais, Diane Pigeon.

Topic: Canadian Identity and History
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Reduction of <i>Streptococcus mutans</i> Adherence and Dental Biofilm Formation by Surface Treatment with Phosphorylated Polyethylene Glycol

ABSTRACT Initial attachment of the cariogenic Streptococcus mutans onto dental enamel is largely promoted by the adsorption of specific salivary proteins on enamel surface. Some phosphorylated salivary proteins were found to reduce S. mutans adhesion by competitively inhibiting the adsorption of S. mutans -binding salivary glycoproteins to hydroxyapatite (HA). The aim of this study was to develop antiadherence compounds for preventing dental biofilm development. We synthesized phosphorylated polyethylene glycol (PEG) derivatives and examined the possibility of surface pretreatment with them for preventing S. mutans adhesion in vitro and dental biofilm formation in vivo. Pretreatment of the HA surface with methacryloyloxydecyl phosphate (MDP)-PEG prior to saliva incubation hydrophilized the surface and thereby reduced salivary protein adsorption and saliva-promoted bacterial attachment to HA. However, when MDP-PEG was added to the saliva-pretreated HA (S-HA) surface, its inhibitory effect on bacterial binding was completely diminished. S. mutans adhesion onto S-HA was successfully reduced by treatment of the surface with pyrophosphate (PP), which desorbs salivary components from S-HA. Treatment of S-HA surfaces with MDP-PEG plus PP completely inhibited saliva-promoted S. mutans adhesion even when followed by additional saliva treatment. Finally, mouthwash with MDP-PEG plus PP prevented de novo biofilm development after thorough teeth cleaning in humans compared to either water or PP alone. We conclude that MDP-PEG plus PP has the potential for use as an antiadherence agent that prevents dental biofilm development.

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
At The Heart Of The Twelve Years’ Truce Controversies: Conrad Vorstius, Gerard Vossius And Hugo Grotius

The period of the Twelve Years Truce between the Southern and the Northern Netherlands (16091621) was one of the most turbulent episodes of seventeenth-century Dutch history. At the heart of the truce controversies that made the period of the Truce so turbulent were three scholars who tried to preserve the peace in church and country by a scholarly approach to the problems of that period: the Leiden professor Conrad Vorstius from Steinfurt; the rector of the Latin School of Dordrecht, Gerardus Joannes Vossius; and the famous scholar and diplomat Hugo Grotius. This chapter presents the history of these scholars in seven snapshots. Vossius, Vorstius and Grotius tried to point out a safe middle passage to those setting the churchs course, but their signals were not received or were taken amiss. Vossius and Grotius painfully had to rebuild a worthwhile future, a future that Vorstius did not even live to see. Keywords: Conrad Vorstius; Dutch history; Gerard Vossius; Hugo Grotius; Twelve Years Truce

Topic: Seventeenth-Century Political and Philosophical Thought
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
The synthesis and stereochemical assignment of <i>exo</i>‐7‐phenyl‐2,5‐dioxabicyclo[4.1.0]heptane

Abstract The synthesis and stereochemical assignment of exo ‐7‐phenyl‐2,5‐dioxabicyclo[4.1.0]heptane is reported. The stereochemical assignment was made based on data obtained from variable temperature nmr spectra.

Topic: Analytical Chemistry and Chromatography
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Thermodynamic analysis of preliminary design of power plant unit I Patuha, West Java, Indonesia

Patuha geothermal field in west Java, Indonesia has nine production wells and four non-commercial wells that are intended for power plant unit 1. The noncommercial wells can be used as injection wells. The production wells have enthalpies that range between 2400 and 2700 kJ/kg with non-condensable gas contents ranging between 1.10 and 1.77 %-weight of steam. The objective of this study was to determine the optimum output power to be generated using a singleflash system geothermal energy conversion model. The study is based on thermodynamic analyses and uses the Engineering Equation Solver software for its calculations. The results show that with the current supply from the existing nine wells, the turbine can produce 60,130 kW with a power output of 56,262 kW. This value is generated by a 6 bar separator pressure and a 0.08 bar-a condenser pressure. The steam ejector would consume 6.5 kg/s steam, equivalent to about 2,922 kW of electrical power. The auxiliary power needed for pumping, the cooling tower fan and other applications totals 3,868 kW. To obtain optimum output power and reduce equipment size, it is suggested that the power plant be designed using 6.5 bar separator pressure and a 0.1 bar-a condenser pressure. With these pressures, the design turbine-generator would generate 58,141 kW and the output power would be 55,417 kW. The steam ejector would consume 5.2 kg/s steam, equivalent to about 2,327 kW of electrical power. The auxiliary power for pumping, cooling tower fan and other applications would equal 2,724 kW. A double-flash system was also analysed to improve the single-flash plant. By adding a second flash on the separation water, the plant would generate an additional 1,251 kW output power. Also, combined with low-pressure steam from non-commercial wells, the plant could generate an additional 4,661 kW output power. The extra output power would add 8.4% to the single-flash plant output power.

Topic: Geothermal Energy Systems and Applications
Subfield: Renewable Energy, Sustainability and the Environment
Field: Energy
Domain: Physical Sciences
Study of the first excited state in 5Li

The reaction 6Li(3He, α)5Li(α)p has been studied with a 1.8 MeV incident 3He beam. Coincidence spectra (α - α) were measured at θ1 = 25°, 35°, 40° and θ2 = - 150°. The purpose was to locate the first excited state of 5Li. The analysis yields Ex = 3.2 ± 0.2 MeV and Γ = 1.5 ± 0.5 MeV .

Topic: Nuclear physics research studies
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Fuzzy tolerance neighborhood approach to image similarity in content-based image retrieval

The main contribution of this thesis, is to define similarity measures between two images with the main focus on content-based image retrieval (CBIR). Each image is considered as a set of visual elements that can be described with a set of visual descriptions (features). The similarity between images is then defined as the nearness between sets of elements based on a tolerance and a fuzzy tolerance relation. A tolerance relation is used to describe the approximate nature of the visual perception. A fuzzy tolerance relation is adopted to eliminate the need for a sharp threshold and hence model the gradual changes in perception of similarities. Three real valued similarity measures as well as a fuzzy valued similarity measure are proposed. All of the methods are then used in two CBIR experiments and the results are compared with classical measures of distance (namely, Kantorovich, Hausdorff and Mahalanobis). The results are compared with other published research papers. An important advantage of the proposed methods is shown to be their effectiveness in an unsupervised setting with no prior information. Eighteen different features (based on color, texture and edge) are used in all the experiments. A feature selection algorithm is also used to train the system in choosing a suboptimal set of visual features.

Topic: Advanced Image and Video Retrieval Techniques
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences