jimnoneill/paper-to-field-training huggingface dataset:
Abstract 3775: Use of RLI-15 a clinical grade fusion protein with IL-15 superagonistic activity for the activation of anti-tumor immune response

Abstract RLI-15, a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain represents a promising candidate for the induction of anti-tumor immunity. RLI-15 was designed to bypass the need of endogenous IL-15Rα, thereby leveraging the activity of IL-15 in vivo on target immune cells. RLI-15 stimulates the proliferation and the cytotoxic activity of natural killer (NK) cells and memory CD8+ T cells with no significant expansion and activation of regulatory T cell compartment. RLI-15 was previously shown to exhibit a potent anti-metastatic activity in B16F10 melanoma and Renca renal cell carcinoma mouse models. RLI-15 also significantly delayed tumor growth and prolonged survival when combined with anti-PD1 therapy in CT26 and MC38 colon carcinoma models. Here, we report that the combination treatment with clinical-grade RLI-15 and an anti-PD1 antibody leads to a significant anti-tumor efficacy in a TRAMP-C2 prostate cancer mouse model with 70 % of mice remaining tumor free after the treatment. We evaluated the optimal schedule of such combination therapy to set the basis for the design of upcoming clinical trials. We further tested how the administration schedule affects the pharmacodynamics properties of clinical-grade RLI-15 and translates into the anti-tumor efficacy in metastatic Renca and CT26 mouse models. In cynomolgous monkeys, various schedules of administration of RLI-15 showed a dose-dependent expansion of peripheral blood lymphocytes, predominantly of NK cell and memory CD8+ T cell compartments. The toxicity in mice and cynomolgous monkeys was evaluated to determine the maximal tolerated dose of RLI-15. Furthermore, the activity of clinical-grade RLI-15 was tested in vitro on human PBMCs and the superiority over IL-2 and IL-15 stimulatory capacity has been confirmed. The complex analysis of RLI-15 behavior and of the induced anti-tumor immune response will be explored in the design of a planned Phase I clinical study in patients with both solid tumors and hematological malignancies. Citation Format: Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Barbora Tomalova, Marek Kovar, Romana Mikyskova, Milan Reinis, Guy de Martynoff, David Bechard, Ulrich Moebius, Radek Spisek. Use of RLI-15 a clinical grade fusion protein with IL-15 superagonistic activity for the activation of anti-tumor immune response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3775.

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Design of integral biorthogonal wavelet filter for aviation image compression

In the aviation image compression,wavelet is usually adopted,which has the characteristics of linear phase,regularity property,vanishing moment,complete reconstruction,good real-time performance,and is suitable for hardware realization.According to the wavelet filter design,we put forward a method for constructing integral biorthogonal wavelet filter based on image compression.Considering the principle of choosing best wavelet filter and taking CDF9-7 as the reference,we used the compression result as the standard to construct a better integral biorthogonal wavelets filter,and adopted the aviation image as the standard training image.The compression ratio,PSNR and reserved energy percentage after compression are taken as parameters to look for the best wavelet filter.Experiment result showed that this method can carry out very simple operation without floating-point multiplication,thus can reduce the operation and hardware realization complexity.

Topic: Advanced Algorithms and Applications
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
SH3459252.08FU

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.

Topic: Agricultural pest management studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The Therapeutic Use of Music in Critical Care.

Abstract : Music therapy is an area that is oftentimes not widely accepted in the highly technological environment of the critical care unit. This is unfortunate since music has been an integral part of healing dating back to ancient times. An extensive review of nursing research literature indicates physiological and psychological benefits to music therapy. These benefits include reductions in blood pressure, heart rate, respiratory rate, pain and anxiety, along with increases in tolerance levels for patients suffering from acute and chronic pain. The effectiveness of this intervention is dependent upon how well the individual can relate to the music selection. Music therapy promotes a holistic approach to patient care that the critical care Clinical Nurse Specialist can incorporate into the health care team through advanced practice, education, consultation, research and managerial roles. Music therapy is not to be viewed as an alternative to traditional healing modalities but as a complementary addition to standard nursing practice.

Topic: Music Therapy and Health
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
A concise history of the South African Defence Force (1912-1987)

As the SA Defence Force celebrates its 75<sup>th</sup> anniversary, it can look back with pride at a truly remarkable history. Established just two years after Union, the fledging force was to be severely tested within the first two years of its existence to a degree perhaps unparalleled in the history of modern armies. Just over a year after its formation, when it still existed more on paper than in fact, the Union Defence Force (UDF) was called upon to suppress a violent industrial strike on the Reef. Having passed its first test with flying colours, the UDF was confronted a few months later by the far more serious crises of internal rebellion and World War. Once again, however, the young organization proved equal to the occasion, and by the end of the Great War the UDF had developed into a battle-hardened, professional force respected the world over for its prowess, courage and endurance in the field.

Topic: Military, Security, and Education Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Paradoxie der Machttheorie

The 4th edition of the first volume of this work provides an update of the commentary on the preamble and articles 1 to 19 in case law and literature. The structure of the book has been retained and its content supplemented by more recent developments, such as the implications of Europeanisation and digitalisation as well as the Corona pandemic. As of the 4th edition, Frauke Brosius-Gersdorf has taken over the editorship of the commentary.

Topic: German legal, social, and political studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Quantitative measures of the accuracy, comprehensibility, and completeness of a fuzzy expert system

Using optimization tools such as genetic algorithms to construct a fuzzy expert system (FES), focusing only on its accuracy without considering comprehensibility may result in a system that is not easy to understand or the so called a black box model. To exploit the transparency features of FESs for explanation in higher-level knowledge representation, a FES should provide high comprehensibility while preserving its accuracy. The completeness of fuzzy sets and rule structures should also be considered to guarantee that every data point has a response output. This paper proposes some quantitative measures to determine the degree of the accuracy, comprehensibility, and completeness of FESs. These quantitative measures are then used as a fitness function for a genetic algorithm in an optimally built FES.

Topic: Fuzzy Logic and Control Systems
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Open Education: The Need and Opportunity for Greater Visibility within the School

No AccessLanguage, Speech, and Hearing Services in SchoolsEditorial1 Jul 1973Open Education: The Need and Opportunity for Greater Visibility within the School Roberta G. London Roberta G. London Google Scholar More articles by this author https://doi.org/10.1044/0161-1461.0403.148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Additional Resources FiguresReferencesRelatedDetails Volume 4Issue 3July 1973Pages: 148-150 Get Permissions Add to your Mendeley library HistoryReceived: Feb 27, 1973Accepted: Apr 27, 1973 Published in issue: Jul 1, 1973 Metrics Topicsasha-topicsleader-topicsasha-article-typesCopyright & PermissionsCopyright © 1973 American Speech-Language-Hearing AssociationLoading ...

Topic: Education and Technology Integration
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Atheism and Theistic Belief

Abstract This chapter shows that despite its popularity, eliminativism is not the only option for the atheist to adopt. It draws on recent work in sociology, psychology, economics, and other related fields to begin to sketch some reasons why atheists should reconsider the eliminativist approach. The chapter is structured as follows. Section I starts with recent work in meta-ethics by providing an overview of the leading options the moral error theorist has in responding to what (in her mind) are widely held false ethical beliefs. Section II then takes this error's theoretic framework from meta-ethics and shows how a parallel set of issues arises for the atheist with respect to genuine theistic believers. Section III summarizes a range of empirical research which suggests that theistic beliefs and practices are positively correlated with a number of widely held social goods. This research is used to argue that, all things considered, perhaps atheists should not work towards the promotion of a broadly secular society. Section IV considers a number of objections to this claim, and Section V concludes with a discussion of an additional option for the atheist to consider.

Topic: Theology and Philosophy of Evil
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Education and Training in Ergonomics in the Netherlands†

A survey has been made concerning the teaching of ergonomics in the Netherlands. At the tertiary school level of the national educational system and in special courses, sponsored by the Dutch Ergonomics Society, some teaching can be found. It appears that much room for expansion is available, especially in curricula of technological universities and higher vocational schools. It seems to be fruitful in new courses to shift the stress from physiological and psychological theory towards technical, designing and organisational applications and from diagnosis to prevention.

Topic: Ergonomics and Human Factors
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Scheduling ammunition loading and unloading for U.S. Navy ships in San Diego

Tomahawk cruise missiles (TCM) cost over one million dollars and are in short supply. U.S. Navy ships require TCM and other conventional ammunition be loaded in appropriate amounts prior to deploying to sea. A typical deployment lasts for six months and, when completed, any remaining ammunition must be unloaded and made ready for other deploying ships. For ships under Commander, Naval Surface Force U.S. Pacific Fleet (SURFPAC), about 3,500 tons of ammunition must be loaded and unloaded annually; this currently costs 14 million dollars for just pilots, tugboats and fuel. This thesis formulates and solves an integer linear program, Surface Navy Scheduler (SNSKED), to prescribe an ammunition load and unload schedule for San Diego homeported ships. SNSKED seeks a schedule with minimized costs subject to constraints on ships availability, port capabilities and support assets. We test SNSKED on a realistic quarterly scenario consisting of 19 combatant ships, three weapons stations, two ammunition ships, five mission types, two ammunition types, and three ways of loading ammunition. SNSKED provides optimal schedules that reduce costs by over 16 percent. We also use SNSKED to evaluate different operational policies, ammunition port utilization, and ammunition loading times.

Topic: Defense, Military, and Policy Studies
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
ChemInform Abstract: Carotenoproteins: Advances in Structure Determination.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Topic: Antioxidant Activity and Oxidative Stress
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Operating Strategy of Chemical Looping Systems with\nVaried Reducer and Combustor Pressures

In\nchemical looping technology when applied to gasification, reforming,\nand chemical syntheses, the operating pressure is an important factor\nthat dictates the reactant conversion and product formation economics\nof the technology for the processes. Common consideration of the operating\npressure for the chemical looping system that includes reducer/fuel\nreactor and combustor/air reactor operation is based on the condition\nin which the reducer and the combustor are operated under similar\npressures. This study considers another operating condition, characterizing\nthe Fan chemical looping system, where the reducer and the combustor\nare operated under different pressures while solids are continuously\nor discontinuously circulating through the loop system. As an example,\nthe chemical looping natural gas conversion to syngas with the eventual\nproduction of liquid fuels is given in this study. This example illustrates\nthe thermodynamic limits and their associated compression duty with\nchemical looping syngas production at pressures between 1 and 30 atm,\nwith a goal of obtaining syngas suitable for cobalt based Fischer–Tropsch\nsynthesis at 30 atm. The adaptation of thermodynamic operating conditions\nto maximize syngas yield and balance between the syngas compression\nand the air compression are discussed in this study over a range of\noperating pressures and temperatures. Further, a novel operating strategy\ncharacterized by differential operating pressures between the fuel\nreactor and the air reactor in a continuous solid flow system is presented.\nSuch a strategy allows the fuel reactor to operate at elevated pressures,\ncloser to the syngas requirements of downstream units, while the air\nreactor operates near the ambient pressure conditions. This strategy\nhas broad implications for other process system applications such\nas reaction–regeneration and adsorption–desorption processes\nwhere pressure variations are a key part of the optimum operation\nconsiderations. Considering the cost of the key components of the\nsystem including the reactors, valves, and compressors, such a strategy\nis shown to reduce the capital cost for the chemical looping system\nby 29% compared to equal pressure chemical looping reforming.

Topic: Chemical Looping and Thermochemical Processes
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Effect of nitrogen and sulphur on the growth and yield of T. Aman rice (BRRI Dhan 87)

Efficient use of nitrogen (N) and sulphur (S) is crucial for enhancing rice productivity in Bangladesh, where nutrient deficiencies significantly limit yields. This study aimed to evaluate the combined effects of N and S fertilization on the growth, yield, and soil fertility of traditional T. Aman rice (BRRI Dhan 87). A field experiment was conducted during the 2019 T. Aman season at the Agronomy Field Laboratory, Sher-e-Bangla Agricultural University, Dhaka, following a randomized complete block design (RCBD) with 12 N-S fertilizer combinations and three replications. Results revealed that N and S significantly (p&lt;0.05) influenced plant growth, yield attributes, and soil properties. The highest grain yield (5.67 t ha-¹) and straw yield (6.88 t ha-¹) were recorded under the N120S12 treatment, representing a 98.9% yield increase compared to the control (2.85 t ha-¹). The same treatment produced the tallest plants (131.78 cm), highest effective tillers (15.33 hill-¹), filled grains (140.37 panicle-¹), and 1000-grain weight (57.00 g). Post-harvest soil analysis showed improved organic matter (1.42%), total N (0.66%), and available P (27.03 ppm) under N120S12. The findings manifest that an integrated application of 120 kg N ha-¹ and 12 kg S ha-¹ optimizes yield performance and enhances soil fertility while minimizing resource losses. These results provide a sustainable nutrient management strategy for improving rice productivity in Bangladesh in similar agro-ecological zones.

Topic: Agricultural Science and Fertilization
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Spectral analysis of bubble sounds in decompressed guinea pigs.

Doppler ultrasonic monitoring was used to detect bubbles in sixteen guinea pigs subjected to a simulated air-dive profile of 9 ATA for 25 minutes. After completion of the decompression, eight subjects did not demonstrate any signs of decompression sickness (DCS), two developed paraplegia and six died. Under sedation, the Doppler ultrasonic bubble detector was placed precordially to record the bubble signals in both pre-dive and post-dive. The recorded signals were analyzed with a high resolution signal analyzer to compare changes between pre-dive and post-dive spectrograms. Bubble signals appeared in the frequency range between 0.64 +/- 0.02 KHz and 6.08 +/- 0.30 KHz. In terms of the net spectral level versus frequency areas (difference between pre-dive and post-dive spectrograms), the mean areas in the paraplegia group and the death group were significantly larger than those in the group without DCS. Therefore, we concluded that the spectral analysis may be an objective and quantitative adjunctive method to the interpretation of Doppler bubble signals.

Topic: Cardiovascular and Diving-Related Complications
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Advances in cooperative wireless networking: Part I [Guest Editorial]

Over the last few years, fundamental research has demonstrated the great potential of cooperative wireless networking in increasing system capacity and enlarging the coverage area as well as enhancing quality of service (QoS) by taking advantage of cooperative diversity and multiplexing. Consequently, cooperative wireless networking has become one of the widely recognized features for future wireless communication systems. While the conventional research mainly focuses on relatively simple cooperative relay topologies or cooperation schemes under the existing infrastructure networks, cooperative networking for future wireless systems has a unique spectrum of features. Specifically, the frequent user cooperation and interaction empower mobile users with a new role as mobile service providers, in contrast to their traditional role as only consumers. In this sense, mobile users' cooperation strategy and decisions are sensitive to not only the QoS requirements of the end users' applications, but also their own benefits as rewards for providing mobile services. Moreover, the cooperation provided by mobile users does not have to rely heavily on infrastructure networks.

Topic: Cooperative Communication and Network Coding
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Karyotypic studies in Garra lamta and Mystus cavassius (Pisces)

Karyomorphological studies were made on males of Garra lamta (Faro : Cyprinidae) and on both sexes of Mystus cavassius (Faro : Bagridae) from their kidney metaphase complements. Garra lamta had 2n = 50 chromosomes alignable into 25 homomorphic pairs comprising 3 pairs of metacentrics, 9 pairs of submeta- eentrics, 6 pairs of subtelocentrics and 7 pairs of telocentrics (NF = 86). Mystus cavassius had 2n = 58 chromosomes in both sexes and their karyotypes revealed 29 pairs of homomorphic chromosomes consisting of 7 pairs of metacentrics, 13 pairs of submetacentrics, 2 pairs of subtelocentrics and 7 pairs of telocentrics (NF = 102). No sex chromosome was identifiable in any sex of the two species.

Topic: Chromosomal and Genetic Variations
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The Effect of Core Muscle Training Program on Balance Ability

The purpose of this study was to investigate the effects of core muscle training on balance ability. Forty subjects in their 20s participated in a 6 week core muscle training program. Balance ability before and after the intervention were assessed and analyzed using the Romberg test, which was conducted on the floor, pedalo, and balancefit. The differences between the measurement methods of balance ability using varied platforms was also compared and analyzed.After the 6-week core exercise training program, the training group represented statistically significant increases in all 3 methods for static balance ability. In the control group, all 3 methods represented no statistically significant increases. Upon comparing the different methods of the Romberg test, there were no notable differences between conducting the test on varying platforms for both groups.This study suggests that the core muscle exercise training program increased the balance ability.

Topic: Diverse Approaches in Healthcare and Education Studies
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Optimal minimax algorithm for integrating fast oscillatory functions in two dimensions

In this paper, we give a complete description of efficient formulae for the numerical integration of fast oscillating functions of two variables. The focus is on the case encountered frequently in many engineering applications where an accurate value of the Lipschitz constant is not available. Using spline approximations, we demonstrate the main idea of our approach on the example of piecewise bilinear interpolation, and propose optimal‐by‐order (with a constant not exceeding two) cubature formulae that are applicable for a wide range of oscillatory patterns. This property makes the formulae indispensable in many engineering applications dealing with signal processing and image recognition. Illustrative results of numerical experiments are presented.

Topic: Mathematical Approximation and Integration
Subfield: Numerical Analysis
Field: Mathematics
Domain: Physical Sciences