jimnoneill/paper-to-field-training huggingface dataset:
[Granulocytopoiesis in acute lymphoblastic leukemia in children].

The number, proliferative potential and differentiation potentialities of bone marrow granulocytic-macrophagal precursors were investigated in 130 ALL patients (77 children in the acute period of disease, 53 children in remission) and in the bone marrow of 65 controls without hematologic pathology. A decrease in the number of clonogenic precursors was observed in all stages of acute lymphoblastic leukemia, the decrease being particularly marked in the acute period of disease characterized by substantial bone marrow infiltration by leukemic cells. A decrease in the number of precursors and their proliferative potential was shown to be associated with the influence of leukemic blasts. In remission the numerical reduction of the precursor pool was determined by a cytostatic therapeutic effect. The ability to differentiation of granulocytic and macrophagal clonogenic precursors in ALL children was unchanged.

Topic: Acute Myeloid Leukemia Research
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Measurement of crystallization of potassium bromate from its quiescent aqueous solution by differential scanning calorimeter. Homogeneous nucleation rate.

To examine the validity of the procedures for measurementof homogeneous nucleation rate in the previous work1^the rate of potassium bromate from its quiescent supersaturated aqueous solution was measured in terms of the waiting time by using a differential scanning calorimeter and analyzed by the rate expression proposed previously.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Evaluation of the proteomic profile in saliva of brazilian home-based and informal workers

BACKGROUND AND AIM: The Brazilian city of Limeira consolidates a pole of jewelry production with homemade and informal processes of assembly, welding, and electroplating, constituting a scenario of outsourced services. These processes can expose workers to potentially toxic elements (PTE: Hg, Pb, Ni, Cd, Zn, As, Cu, Cr, and Sn), and the productive chain encompasses the related families. This study aimed to evaluate the effects of PTE exposure on protein expression performing a proteomic approach. METHODS: Saliva samples were collected from 26 individuals, Welders Group (n=13) and Control Group (n=13). Blood PTE levels were determined by ICP-MS and saliva samples' proteins by UPLC coupled to a mass spectrometry (Q-TOF), shotgun runs. Bioinformatics analysis was performed using PEAKS Studio 8.5. RESULTS:Significant differences were found for Sn (p0.000004) and Cu (p0.0005) concentrations between the groups. In total, 979 proteins were identified in both groups and, removed the proteins with fifty percent of missing values, and substituted by mean values, 411 proteins. The data was autoscaled, then performed the multivariate analyses using MetaboAnalyst 4.0. Principal components analyses and partial least square discriminate analysis showed a group separation. By t-student test performed, we found 40 significant proteins (p0.05). Gene ontology analysis showed biological processes more represented for viral transcription, maintenance of cell polarity, nuclear-transcribed mRNA catabolic process, and nonsense-mediated decay. Pearson correlation showed 28 significant proteins correlated with metals (p0.05). ARP2 and 1433G proteins were correlated with Pb and Sn. IF4A1, ARF6, RS10, PLBL1 and RS9 correlated with Sb. The proteins MNDA, CRBG1, RAB5B, SAP, LV39, NUCB1, CAPZB, HV64D, IMB1, ARP3, LV743, SPR1A, HV459, HV461, HVD82, HVD34, DDX3X, CDC42, PDIA6, CAN1, TM11D, ARG1, FLNB correlated with Sn. We found 16 of these proteins with greater expression in the Welders group. CONCLUSIONS:The informal, home and outsourced work performed by welders is influencing their internal exposome. KEYWORDS: Proteomics, toxic elements, informal work.

Topic: Heavy Metal Exposure and Toxicity
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
DEVELOPMENT OF A SPECIALISED TAPE MEASURE TO ESTIMATE THE SIZE-SPECIFIC DOSE ESTIMATE

Abstract The risk in computed tomography (CT) examinations is radiation exposure. We aimed to develop a specialised tape measure for determining the size-specific dose estimate (SSDE) for patients undergoing CT scans. The scanning parameters used were those of the abdominal protocol in our institute. With this method, the SSDE220 and standard deviations obtained from CT images for the liver, pelvic and lung areas, corresponded closely to the SSDEtape and standard deviations obtained using the tape measure. We thus devised a new idea that allows the estimation of the SSDE220 using a specialised tape measure before the CT examination, allowing for an informed explanation of the radiation dose to the patient. Although the tape measure developed in this study is specific to one particular CT instrument, the method could be adapted to a wide range of radiography applications.

Topic: Radiation Dose and Imaging
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Negotiating pleasure and sexual risk: Alcohol use among female university students

This study explores how female university students navigate the interplay between the pleasure that alcohol gives them and the risks to their sexual safety it poses. This mixed-method study employed an open-ended questionnaire administered by a student-researcher. The sample comprised 76 voluntary female students who reported consuming alcohol. The findings indicate that women who consume alcohol exercise personal agency in their self-expression, yet they do so within a context of gender and sexual violence. Participants articulated various strategies for mitigating risks to their sexual safety while drinking, such as consuming alcohol within supportive social networks, avoiding financial dependence, and regulating their alcohol intake. Contribution: This article contends that alcohol consumption at university plays a significant role in the expression of gender and sexuality, offering both pleasure and risk. Consequently, arguments about equality must acknowledge risk-taking as an inherent aspect of university life for young adults and prioritise strategies for managing alcohol-related risks rather than simply advocating for blanket prohibitions on alcohol use.

Topic: Gender Roles and Identity Studies
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
LONG-TERM CORRELATED RESPONSE, INTERPOPULATION COVARIATION, AND INTERSPECIFIC ALLOMETRY

A model of long-term correlated evolution of multiple quantitative characters is analyzed, which partitions selection into two components: one stabilizing and the other directional. The model assumes that the stabilizing component is less variable than the directional component among populations. The major result is that, within a population, the responses of characters to selection in the short term differ qualitatively from those in the long term. In the short term, the responses depend on genetic correlations between characters, but in the long term they are only determined by the fitness functions of stabilizing and directional selection, independent of genetic and phenotypic correlations. Treating the stabilizing component as a constant and assuming the directional component to vary among populations, I present formulas for the interpopulation covariation and interspecific allometry, which are functions of the intensity matrix of stabilizing selection. Particular attention is paid to the relationship between intra- and interpopulation correlations.

Topic: Animal Behavior and Reproduction
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Mineral-Rich Brines from Portuguese Coastal Lagoons: Insights into Their Use in Thalassotherapy and Skin Care

This study characterized saline waters from traditional and semi-industrial saltpans located in the Ria Formosa and Ria de Aveiro Portuguese coastal lagoons, aiming to evaluate their potential for thalassotherapy and dermatological applications. Five saline water samples were collected and analyzed for physicochemical parameters (pH, electrical conductivity, dissolved oxygen, and total dissolved and suspended solids) and chemical composition (major, minor, and trace elements), complemented by SEM-EDS analyses of the suspended solids. All samples exhibited salinities above 70 g/kg, classifying them as mineral-rich brines. Sodium was the dominant element, followed by Mg, K, and Ca, with concentrations significantly higher than those of seawater. Apparent geochemical differences were observed between the two lagoons, with Ria de Aveiro water enriched in Ca, while Ria Formosa showed higher Mg and K contents. Suspended solids were composed mainly of halite, gypsum, K-Mg salts, and biogenic aggregates, reflecting the interaction between evaporitic and microbial processes. These findings highlighted the high therapeutic potential of Portuguese saline waters for skin-related applications, supporting the safe use of natural saline resources in evidence-based wellness and dermatological practices.

Topic: Therapeutic Uses of Natural Elements
Subfield: Complementary and Manual Therapy
Field: Health Professions
Domain: Health Sciences
Gastrin-Enhanced Tumor Growth of a Xenotransplantable Human Gastric Carcinoma in Nude Mice

A human tumor line serially transplantable in nude mice, originating from a well-differentiated papillo-tubular adenocarcinoma of the stomach, was established. The growth of this tumor was enhanced by daily injection of C-terminal tetrapeptide gastrin into the mice. Although there was little difference in histology, the gastrin-stimulated tumor had larger glandular spaces filled with mucin-like substance than the control tumor. 3H-thymidine uptake of the gastrin stimulated tumor was higher than that of control, as shown by microradiography and counting of radioactivity in tissue homogenates. The plasma membrane fraction of the tumor revealed positive binding for gastrin and the cytosol fraction contained cyclic AMP dependent- and independent protein kinases. Incubation of tumor slices with gastrin caused a conformational change in the enzymes. Therefore we conclude that this G4 tumor line xenotransplantable in nude mice is sensitive to gastrin in its trophic and secretory mechanisms.

Topic: Cancer Research and Treatments
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Influence of sea cucumbers on chromophoric of dissolved organic matter in multitrophic aquaculture tanks

Background. The effluents of the mono-specific aquaculture contain high concentrations of dissolved nutrients and organic matter, which affect negatively water quality of the recipient aquatic ecosystems. A key feature of water quality is its transparency. Chromophoric dissolved organic matter (CDOM) determines most of the light transmission in the ultraviolet and blue bands in the aquatic ecosystems. A sustainable alternative to mono-specific aquaculture is the integrated multitrophic aquaculture that includes species trophically complementary named “extractive” species. Sea cucumbers are recognized as efficient extractive species, with a high potential to improve water quality, due to the consumption of particulate organic matter (POM). However, the effects of sea cucumbers on CDOM are still unknown. Methods. During one year, we biweekly monitored CDOM in two aquaculture tanks with different trophic structure. One of the tanks (- holothurian tank) only contained the primary species, Anemonia sulcata , whereas the other tank (+ holothurian tank) also contained individuals of Holothuria tubulosa and H. forskali . We routinely performed CDOM absorption spectra from 200 nm to 750 nm and determined quantitative (absorption coefficients at 325 nm) and qualitative (spectral slopes and molar absorption coefficients at 325 nm) optical parameters in the inlet waters, in the tanks, and in their corresponding effluents. Results. Absorption coefficients at 325 nm (a 325 ) and spectral slopes from 275 to 295 nm (S 275-295 ) were significantly lower in the effluents of the + holothurian tank (average: 0.33 and 16 μm -1 , respectively) than in the effluents of the − holothurian tank (average: 0.69 m -1 and 34 μm -1 , respectively), being the former similar to those found in the inlet waters (average: 0.32 m -1 and 22 μm -1 , respectively). This reduction in CDOM absorption appears to be mediated by the POM consumption by the holothurians. The reduction of POM concentration in the +holothurian tank may weaken the process of POM disaggregation into dissolved organic matter, which ultimately might have generated CDOM in the –holothurian tank. Discussion. Extractive species such as holothurians improve water transparency through POM consumption, likely because reduces POM disaggregation into CDOM. We suggest that CDOM monitoring in aquaculture facilities, using automatic probes or even remote sensing, could be a useful tool to trace the effectiveness of extractive species at large scales of time and space.

Topic: Echinoderm biology and ecology
Subfield: Aquatic Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[Influence of a high-carbohydrate meal on taste perception].

1. The consumption of a high-carbohydrate meal influences the sweet and sour taste perception and the effect is sex-dependent: - in men, both the taste sensitivity to saccharose and the hedonic response to sweet taste were decreased, whereas in women such influence was not observed; - in women, the taste sensitivity to citric acid increased and the hedonic response to sour taste decreased, whereas in men such influence was not observed. 2. There is negative correlation between the intensity of taste perception and the hedonic response to the sweet taste both in men and in women after a high-carbohydrate meal, whereas in fasting state such correlation was not observed.

Topic: Nutrition and Health Studies
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Aggregation Indices of Cotton Arthropods in Texas1

Journal Article Aggregation Indices of Cotton Arthropods in Texas Get access Edward P. Pieters, Edward P. Pieters Dept. of Entomology, Texas A&M University, College Station, TX 77843 Search for other works by this author on: Oxford Academic PubMed Google Scholar Winfield L. Sterling Winfield L. Sterling Dept. of Entomology, Texas A&M University, College Station, TX 77843 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 3, Issue 4, 1 August 1974, Pages 598–600, https://doi.org/10.1093/ee/3.4.598 Published: 01 August 1974 Article history Received: 04 December 1973 Published: 01 August 1974

Topic: Insect-Plant Interactions and Control
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Development of Technology for the Production of a Milk Protein Product

Key words: milk, ricotta, syneresis, globulin, albumin, thermophilic bacteria The aim of our research is to obtain a milk protein product similar to ricotta cheese. In its appearance and production technology, ricotta is somewhere between cheese and cottage cheese. But in terms of texture, softness and versatility, this is a unique product. Our idea is to get a superfood from yogurt and ricotta. The new product, due to a special technology, will not contain lactose and will be useful for people with lactose intolerance, as well as children and athletes. The developed technology of the above product will undoubtedly interest local producers and open a new direction for dairy production in Armenia. The production of soft, especially fresh and early ripening cheeses can be widely implemented at existing farm and urban dairy enterprises without significant capital investments, which will increase the volume of cheeses and improve the efficiency of their production. The experimental ricotta was made from reconstituted milk. fat content: 3.2%, dry fat-free substances: 8.2%, density: 1027 kg/m3, titratable acidity: not higher than 21oT. Reconstituted milk was kept for 9-12 hours at 6...8°C for hydration. Based on the results of the research, from the samples made in three ways, the one corresponding to the properties we needed was chosen. In the production by the thermoacid method, the yield was 0.148 kg per 1 liter of milk. It has a pronounced aroma and good taste, delicate, but not uniform, with low taste. The yield of the sample obtained using citric acid by the thermoacid method was 0.157 kg per 1 liter of milk. With a pleasant taste and aroma, delicate, but again not uniform enough. When using calcium chloride by the thermo-salt method, a homogeneous fine-grained clot with good taste and aroma was obtained. Milk yield was 0.165 kg per 1 liter of milk.

Topic: Food Industry and Aquatic Biology
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Crop water budgeting for rainfed cotton for crop planning and management in Coimbatore

Analysis of water balance components was carried out for cotton crop in Annur block of Coimbatore district (11o 14´ to 11o 23´ N latitude and 77o 08´ to 77o 13´E longitude)based on the soil information (1:50, 000scale) and thirty years (1975-2005) climatic data.Soil moisture availability index showed that 37th standard week was found to be highly suitable for taking up cotton sowing due to assured rainfall. The water requirement satisfaction index indicated that about 87 per cent of the crop water requirement is satisfied by the soil moisture in the control section irrespective of soil type. The crop will facemoisture deficit from 4th to 8th standard weeks which coincide with harvesting stage.

Topic: Agricultural Economics and Practices
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Red Cell Distribution Width as a Predictor of Severity of Acute Pancreatitis

Introduction: Acute pancreatitis (AP) is a disorder featured by local and systemic inflammatory response, which manifests as mild, self-limited disorder to severe and sometimes fatal disease. Red cell distribution width (RDW) is reflective of systemic inflammation and has been shown to be effective at predicting severity. This study was aimed to investigate the association between Red cell distribution width as coefficient of variation (RDW -CV) on admission and severity of acute pancreatitis.&#x0D; Method: This was a hospital based prospective study conducted in the Department of Surgery, Nepalgunj Medical College Teaching Hospital for a period of 2 years from July 2017 to June 2019. The patients with acute pancreatitis were categorized into mild, moderate and severe acute pancreatitis. The value of RDW-CV on admission was correlated with the severity of acute pancreatitis.&#x0D; Results: RDW-CV on admission was significantly correlated with the severity of AP (p value &lt;0.001). Receiver Operating Characterstic (ROC) analysis showed that RDW has very good discriminative power for severe acute pancreatitis [AreaUnder curve (AUC) 0.963, 95% CI, 0.919 to 1.007, p-value &lt;0.001] but not useful to predict mild AP (AUC 0.157, 95% CI, 0.063 to 0.250, p value 0.14) and moderate AP (AUC 0.397, 95% CI, 0.252 to 0.541, p value 0.234). The maximum sensitivity and specificity of detecting severe AP was 95.7% and 91.5% respectively. The positive predictive value (PPV) and negative predictive value (NPV) was 84.6% and 97.7% respectively.&#x0D; Conclusion: RDW-CV width on admission is a predictor of severity in patients with severe acute pancreatitis.

Topic: Inflammatory Biomarkers in Disease Prognosis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
The quality and volatile‐profile changes of camellia oil (<b><i>Camellia oleifera</i></b> Abel) following bleaching

Abstract Bleaching is a necessary step in the production of refined camellia oil ( Camellia oleifera Abel) since crude oil has a dark brown color, due to pigments extracted from the seed coat during pressing, which is unacceptable to consumers. In order to understand the quality change and oxidative state of camellia oil in the bleaching step, measurements of various quality parameters, i.e. peroxide value (POV), free fatty acids (FFA), UV absorbance, and the volatile profiles of crude and bleached oils, were carried out. The results showed that FFA, K 270 , and K 232 increased, whereas POV decreased, with increase of the activated earth dosage of 0–4% and of bleaching time from 0 to 40 min at 110 °C. As the amount of activated earth was increased from 0 to 4% with bleaching at 110 °C for 30 min, various classes of volatile compounds increased in concentration: aldehydes (23.7 µg/g), alcohols (13.2 µg/g), esters (8.0 µg/g), alkenes (2.0 µg/g) and ketones (1.9 µg/g). Likewise, when bleaching was carried out at 110 °C with 3% activated earth and the bleaching time varied between 0 and 40 min, the concentrations of volatile compounds also increased: aldehydes (27.7 µg/g), alcohols (18.2 µg/g), esters (7.3 µg/g), ketones (3.2 µg/g) and alkenes (0.6 µg/g). These findings indicate that hydroperoxides in the oil were decomposed into lower‐molecular‐weight products in the process of bleaching and that the extent of this decomposition can be controlled by time and amount of activated earth.

Topic: Edible Oils Quality and Analysis
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Managing Lessons Learned

An organization’s knowledge is built on the experience of its human resources, such as individual competencies, group working experiences, problem-solving abilities, and the lessons learned, which these resources use during the execution of tasks or processes. This organizational knowledge is stored in individual minds, or implicitly encoded in organizational processes, services, and systems. In the context of knowledge intensive organizations or learning organizations, besides labor, capital, and land, this experience-based knowledge has been recognized as an important productivity factor. For example, Lessons Learned (LL) are crucial to the learning organization’s continued success. LL were originally conceived as guidelines, tips, or checklists of what went right or wrong in a particular event or organizational business process. A Lessons Learned System (LLS) is a type of knowledge management system that serves the purpose of capturing, storing, disseminating, and sharing an organization’s verified LL, but Lessons Learned Systems have not been well studied and researched. Based on the literature review, the authors develop an evaluation framework for understanding LLS research. The framework identifies six dimension areas of emphasis in LLS research: LL process, LL representation, LL content, LL architecture, organization type, and type of processes. This chapter introduces the evaluation framework and concludes with a discussion of emerging issues, new research directions, and the practical implications of LLS research.

Topic: Big Data and Business Intelligence
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences