jimnoneill/paper-to-field-training huggingface dataset:
Validation data confusion matrix.

&lt;div&gt;&lt;p&gt;In addition to affecting people’s bodily and mental health, the Covid-19 epidemic has also altered the emotional and mental well-being of many workers. Especially in the realm of institutions and privately held enterprises, which encountered a plethora of constraints due to the peculiar circumstances of the epidemic. It was thus anticipated that the present study would use a group method of data handling (GMDH) neural network for analyzing the relationship of demographic factors, Coronavirus, resilience, and the burnout in startups. The test methodology was quantitative. The research examined 384 startup directors and representatives, which is a sizable proportion of the limitless community. The BRCS, the MBI-GS, and custom-made assessments of stress due to the Coronavirus were all used to collect data. Cronbach’s alpha confirmed the polls’ dependability, and an expert panel confirmed the surveys’ authenticity. The GMDH neural network’s inherent potential for self-organization was used to choose the most useful properties automatically. The trained network has a three-layered topology with 4, 3, and 2 neurons in each of the hidden layers. The GMDH network has significantly reduced the computational load by using just 7 parameters of marital status, stress of covid-19, job experience, professional efficiency, gender, age, and resilience for burnout categorization. After comparing the neural network’s output with the acquired data, it was determined that the constructed network accurately classified all of the information. Among the achievements of this research, high accuracy in predicting job burnout, checking the performance of neural network in determining job burnout and introducing effective characteristics in determination of this parameter can be mentioned.&lt;/p&gt;&lt;/div&gt;

Topic: Peanut Plant Research Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
An Introduction to Linear Algebra: A Curricular Unit for Pre-Calculus Students

Matrices are important mathematical tools that facilitate the process of organizing and manipulating data. In this work, the matrix operations of addition, subtraction, scalar multiplication, and matrix multiplication are built logically from the intuition of the students and their knowledge of real numbers. From this knowledge, the concepts of inverses, determinants, and consistency and inconsistency of linear systems of equations are formed. Interesting applications of matrices in the areas of Markov chains, curve fitting, and eigenpairs are included and are not beyond the comprehension of pre-calculus students when they are presented carefully. Pre-calculus students can also appreciate many of the numerical challenges that can be encountered when real-world problems are solved; therefore, we include a discussion of some of these topics.

Topic: Mathematics Education and Teaching Techniques
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
LOW TRANSLATION DOWNSTREAM OF TOR ACTIVATES MYOGENE EXPRESSION AND ENHANCES HEALTH OF BODY MUSCLE IN C. ELEGANS

Abstract Previous studies reported that DR or low nutrient signaling reduces translation and extends lifespan, while attenuating growth and reproduction. In this study using C. elegans as a model organism, we found that reduced translation in neurons or germ tissues increases survival and primes the HSR against unfolded protein stress in adult animals. Surprisingly, lowering translation in these tissues significantly upregulates transcription of several key muscle maintenance genes, including those encoding the myogenic response factor HLH-1 and heavy myosin chain factor UNC-54 and MYO-3. It also improves muscle maintenance according to motility assays. However, reduced translation in muscle tissue does not activate the same level of myogenic gene expression. Instead, lowering translation in striated body muscle results in increased reproduction and accelerated development. To further investigate, we examined maintenance of muscle health via deconvolution fluorescent microscopy and immunostaining. Using computational analyses involving Fiji ImageJ and MATLAB program, we discovered that lowering translation delays decrepitude in body muscle structure, resulting in improved mitochondrial morphology and increased thermotolerance. Here we report that, combining physiological, molecular, and microscopic technique, muscle is protected during low translation, low TOR signaling, or DR. We hypothesize that results reflect evolutionary responses that preserve function required for foraging during nutrient scarcity and accelerate development during times low energy usage and high nutrient abundance.

Topic: Genetics, Aging, and Longevity in Model Organisms
Subfield: Aging
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Renal Transplantation and the Living Donor

Renal transplantation in end-stage renal disease is now an accepted medical procedure but the source and origin of the grafted organ (living donor vs. cadaveric kidney) remain controversial and it appears that each transplant team has to work out its own guidelines. We present the results of questionnaires and interviews of a large number of donors, many of them looking back on their experience with the knowledge that unfortunately, and in the long run, their sacrifice proved to be in vain. All our subjects evaluated their participation as donors in the transplant program in a very positive way. There was general agreement that none of them was significantly harmed by his action and that, in the realms of self-knowledge and feelings of self-worth and self-respect, the act of donorship turned out to be a very positive and very highly valued experience. These donors' opinions and attitudes, their relatively unconflicted conduct, are in sharp contrast with the agonizing appraisal of many a transplant team. It remains the task of the team doctors to weigh and balance risks and advantages of such an intervention and to be the advocate of both the donor and the recipient. It is to them that we offer our findings in the hope that it may help them in that difficult decision-making process.

Topic: Organ Donation and Transplantation
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Amplifying vortex shedding for energy harvesting with active flow control

Energy harvesting from vortex-induced vibrations is a promising technology that relies on the vibrations of bluff bodies due to vortex shedding. Increasing the vibration amplitude at a given free stream kinetic energy is therefore equivalent to enhancing the efficiency of the harvesting device. In this study, we assess the potential of alternate slot blowing to amplify force fluctuations. Pressurized air is ejected alternatingly from the top and bottom parts of the cylinder. Through experimentation in a low-speed wind tunnel ($Re=8,000$), we show that the magnitude of lift fluctuations can be enhanced by up to a factor of three compared to the unforced flow when the actuation is aligned with the natural vortex shedding frequency. Velocity field measurements indicate that this is caused by strong streamline bending whereas, at a higher forcing frequency, vortex shedding is suppressed. The results presented in this article suggest that a significant increase in the dynamic load acting on a cylinder can be achieved with carefully chosen active flow control parameters, thereby promoting future energy harvesting applications.

Topic: Innovative Energy Harvesting Technologies
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Dry Matter Production and Photosynthetic Ability of &lt;i&gt;Oryza officinalis&lt;/i&gt; Wall ex Watt under Salinity Stress Condition

野生稲Oryza officinalis Wall ex Wattの耐塩性を評価するために，耐塩性の高いO. latifolia Desv.，O. sativa L. cv. Pokkaliおよび感受性野生稲のO. rufipogon Griff.，O. australiensis Dominを用いて，播種後60日目から32日間の塩水処理（12 dS m-1 NaCl）を行ない，乾物生産，葉身のイオン含有率および光合成速度を比較した．塩ストレス環境下のO. officinalisおよびO. latifoliaの葉身乾物重の低下程度は，Pokkaliより低かった．またO. officinalisおよびO. latifoliaの葉身水分含有率はPokkaliと同程度であり，葉身のNa+含有率は，Pokkaliより高かった．播種後81日目 （塩水処理21日目） のO. officinalisおよびO. latifoliaの光合成速度は，Pokkaliより低下しなかった．光合成速度と葉内CO2濃度の関係から，O. officinalis，O. latifolia，O. australiensisおよびPokkaliにおける光合成の低下要因は，気孔開閉の影響が大きいと考えられた．しかし，光合成速度と気孔伝導度の関係では，O. officinalisは高い相関，O. latifoliaは中程度の相関が認められた．以上の結果，塩ストレス環境下のO. officinalisは，Pokkaliより葉身にNa+を多く蓄積するにも関わらず，光合成速度および乾物生産の低下は少ないことから，O. latifoliaと同等の耐塩性を有することがわかったものの，光合成速度の律速要因は別であることが示唆された．

Topic: Plant responses to water stress
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
An Effective End-to-End Modeling Approach for Mispronunciation Detection

Recently, end-to-end (E2E) automatic speech recognition (ASR) systems have garnered tremendous attention because of their great success and unified modeling paradigms in comparison to conventional hybrid DNN-HMM ASR systems. Despite the widespread adoption of E2E modeling frameworks on ASR, there still is a dearth of work on investigating the E2E frameworks for use in computer-assisted pronunciation learning (CAPT), particularly for Mispronunciation detection (MD). In response, we first present a novel use of hybrid CTCAttention approach to the MD task, taking advantage of the strengths of both CTC and the attention-based model meanwhile getting around the need for phone-level forced alignment. Second, we perform input augmentation with text prompt information to make the resulting E2E model more tailored for the MD task. On the other hand, we adopt two MD decision methods so as to better cooperate with the proposed framework: 1) decision-making based on a recognition confidence measure or 2) simply based on speech recognition results. A series of Mandarin MD experiments demonstrate that our approach not only simplifies the processing pipeline of existing hybrid DNN-HMM systems but also brings about systematic and substantial performance improvements. Furthermore, input augmentation with text prompts seems to hold excellent promise for the E2E-based MD approach.

Topic: Speech Recognition and Synthesis
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
[Chronic urticaria and infectious diseases].

There is not enough clear-cut data to affirm a direct link between chronic urticaria and infectious diseases, except in occasional case reports. Therefore, systematic screening for infectious markers cannot be recommended in chronic urticaria. A role of Toxocara canis infections should be re-evaluated by controlled studies.

Topic: Urticaria and Related Conditions
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Tandem C–C/C–N Formation via Palladium-Catalyzed\nC–H Activation/Styrenation and Sequential Annulation of &lt;i&gt;O&lt;/i&gt;‑Methylketoxime with Styrenes

A novel route for tandem C–C/C–N\nformation via palladium-catalyzed\nC–H activation/styrenation and annulation of &lt;i&gt;O&lt;/i&gt;-methylketoxime with styrenes to synthesize benzothienopyridines\nand benzofuropyridines has been developed. Furthermore, the intermolecular\nalkenylation of the ketoxime with acrylates produces 3-alkenyl &lt;i&gt;O&lt;/i&gt;-methylketoximes in good to excellent yields. The method\nfeatures mild reaction conditions and good functional group tolerance,\nproviding a direct approach for the preparation of fused heterocycles.

Topic: Catalytic C–H Functionalization Methods
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Marked genetic divergence revealed by allozymes among populations of the guppy Poecilia reticulata (Poeciliidae), in Trinidad

Populations of the guppy Poecilia reticulata from six locations in N. Trinidad were examined by starch gel electrophoresis to estimate their degree of genetic divergence. Variability at seven enzyme-coding loci demonstrated that populations differed markedly in allele frequencies with some allelic substitution between sites (for 23 loci, Nei's mean genetic identity, Ī ranged from 0.869–1.00; the coefficient of gene differentiation, GST= 0.086; and the absolute differentiation between populations, D̄m= 0.044). There was a good correspondence between degree of physical isolation and extent of genetic differentiation, as exemplified by the partitioning of gene diversity (Nei's gene diversity analysis = 66% between river basins; 32% within river basins; 2% within rivers), though there was considerable variability in the contribution of individual loci. Most populations were in Hardy-Weinberg equilibrium, and any significant deviations were due exclusively to heterozygote deficiencies. The patterns of population differentiation are discussed in relation to probable past geological and historical events, and present-day evolutionary forces. Notable among these are previous continental land connections, periodic immigration from N.E. South America, and post-colonization events including differential predation, sexual selection, apparent restricted vagility and small effective population sizes.

Topic: Genetic diversity and population structure
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Photographic Phytography

This paper explores my practice-based research project Arboreal Encounters, a collection of tannin toned cyanotypes made with six heritage oak trees that form an element of my part-time, practice-based Ph.D. at the University of Brighton, UK. It comprises a brief history and background of the project before exploring how photographic practice might interact with and integrate notions of vegetal intelligence within artistic practice. By thinking of the production of Arboreal Encounters as if an invitation to the trees to become part of the process of their own representation, I consider how such interactions might act symbolically as human-plant collaborations and how methods of thinking, as well as doing, may resist notions of the plant as commodity within artistic practice.

Topic: Plant Pathogens and Fungal Diseases
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Surgical limb lengthening--experiences and results].

This paper describes the experiences and results in 172 operative lengthening procedures on 134 patients, performed in the Orthopaedic Department of Charité Hospital in Berlin. The bone length increase was on an average 8.5 cm (min.: 1 cm, max.: 20 cm), this gives altogether a bone increase of over 14 meters. Patients are differentiated in groups of age, indication, localization, mode of procedure (callus-distraction, epiphysealdistraction) and in regard to the used external fixation devices. Authors present their own model of wire fixed external fixateur (so called "Berlin type-external fixateur"), a modification of the original Ilizarov-device. Importance of procedure-planning and time-balance as well as the high rates of complications (146 complications = 84.8%) are discussed.

Topic: Bone fractures and treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Molecular characteristics of class 1 integrons in Salmonella Enterica isolated from poultry and swine

A total of a hundred and fifty Salmonella enterica isolated from poultry and swine representing 31 serovars were used in this study. Antibiotic susceptibility was examined and resistance pattern was analyzed. All the isolates were investigated for occurrence and characteristics of class 1 integrons. Localization of class 1 integrons and their transferability were assessed by conjugal experiment. The presence of Salmonella genomic islands were assessed. The S. enterica strains that were resistant to at least one of antibiotic were 86% and 59.3% was multidrug resistant. Two common resistance patterns found were the SPC-STR-SUL (6.21%) and the AMP-CHP-SPC-STR-SUL-TET-TRI (6.21%) phenotype. The intI1 gene was present in 25.6%, of which 55.5% carried gene cassettes with size ranging from 650 to 2,300 bp. Sequence analysis revealed 10 distinct Integrons profiles (IPs), in which genes blaPSE-1, dfrA1, dfrA12, aadA2, aadA4, silB, incompleted sat and incompleted codB were present in variable regions. The gene cassettes array dfrA1-orfC was most frequenly found among the isolates. Class 1 integrons were identified on conjugative plasmid in 7 Salmonella isolates. SGI1 variants (SGI1-A and SGI1-F) were present in 9 isolates belonging to serovars Albany, Emek, Kedougou and Kingston.

Topic: Salmonella and Campylobacter epidemiology
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Implants and Human Rights, in Particular Bodily Integrity

Human ICT implants can have various implications for human rights. In particular, the right to bodily integrity may be at stake due to the direct connection to the human body. In this chapter, the scope of the right to bodily integrity is discussed. A more detailed discussion on how the right is affected by implants is largely based on biotechnological implants. In this field, the distinction between therapy and enhancement, as well as implications of implants for the concept of the body and its integrity, has been largely debated. Subsequently, the right is approached with a focus on other, non-living implants. Specific emphasis is given on nanotechnological implants and information carriers. It also appears to be relevant whether the implant has an active or a passive functionality. Finally, some concluding remarks are made by pointing at additional challenges for human rights resulting from ICT implants.

Topic: Neuroethics, Human Enhancement, Biomedical Innovations
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Prenatal ultrasonographic diagnosis characteristics analysis of congenital heart big vascular malformation

Objective To analyze the clues for prenatal ultrasonographic diangnosis of congenital heart vessels abnormality.Methods 10 000 cases were collected from the cases who excepted the routine obstetric ultrasound examination and suspected fetal congenital heart defects or other organs anomalies in our hospital from Jan 2011 to Jan 2013.Every one were given Fetal echocardiography including the great arteries and three vessels view and four-chamber view.We evaluated their vessel's size,number,arrangement,location of the transverse aortic arch in relation to the trachea and flow character in great artery on these views.Results 44 cases were found with great vessel anomalies by prenatal ultrasonography,which included 21 cases with abnormal vessel size,11cases with abnormal vessel number,14 cases with abnormal vessel arrangement,2 cases with abnormal location of the transverse aortic archin relation to the trachea,23 cases with abnormal flow character.Conclusion Parallel arrangement of the root of the great artery,abnorm-al vessel size,abnormal vessel number,abnormal location of the transverse aortic arch in relation to the trachea and abnormal flow character are the clues for prenatal ultrasonographic diagnosis of congenital heart great vessel abnormality.Titling slightly the transducer towards the fetal head on four-chamber base view is more reliable means of detecting fetal heart great vessel anomalies.All of them have great value in the clinical.

Topic: Congenital Heart Disease Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Knockdown of lncRNA HCP5 Suppresses the Progression of Colorectal Cancer by miR-299-3p/PFN1/AKT Axis

Ni Bai, Ying Ma, Jia Zhao, Bo Li Department of Laboratory Medicine, The Affiliated Xi&rsquo;an Centre Hospital of Xi&rsquo;an Jiaotong University College of Medicine, Xi&rsquo;an, Shaanxi 710003, People&rsquo;s Republic of ChinaCorrespondence: Bo LiDepartment of Laboratory Medicine, The Affiliated Xi&rsquo;an Centre Hospital of Xi&rsquo;an Jiaotong University College of Medicine, 161 Xi Wu Road, Xi&rsquo;an, Shaanxi 710003, People&rsquo;s Republic of ChinaEmail yo1124yo@163.comBackground: Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system. The lncRNA HCP5 has been reported to affect the progression of tumor in several types of cancer. Here, in this research, we focus on the role and function of lncRNA HCP5 in human colorectal cancer.Materials and Methods: Tissue samples from colorectal cancer patients were used for detecting the expression of HCP5 by qRT-PCR. Proliferation, migration, invasion and apoptotic cells were assessed by CCK-8, colony formation, transwell assays and flow cytometry in SW480 and HCT-116 cells. The interactions between miR-299-3p and HCP5 or PFN1 were analyzed and confirmed by online database and luciferase reporter assays. The changes in PFN1 and AKT proteins were measured by Western blot. In vivo experiment was used to confirm the role of HCP5 in CRC.Results: The expression of HCP5 had a higher level in colorectal cancer samples and cells by qRT-PCR, comparing with the normal colorectal tissues and human normal colon epithelial cell. It was revealed that knockdown of HCP5 inhibited viabilities, migration and invasion, while inducing apoptosis in SW480 and HCT-116 cells. Then, HCP5 negatively regulated the expressions of miR-299-3p, which negatively regulated the expressions of PFN1 by targeting PFN1. Furthermore, miR-299-3p inhibitor could alleviate the inhibiting effect by si-HCP5 on cell process of SW480 and HCT-116 cells. In addition, the lncHCP5/miR-299-3p/PFN1 axis could affect the progression of CRC through activating the AKT signaling. Last, we confirmed that knockdown of HCP5 inhibited the progression of CRC with an in vivo experiment.Conclusion: The experiments and analyses support our hypothesis that knockdown of lncRNA HCP5 suppresses the progression of colorectal cancer by miR-299-3p/PFN1/AKT axis.Keywords: lncRNA HCP5, miR-299-3p, PFN1, AKT, human colorectal cancer

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences