jimnoneill/paper-to-field-training huggingface dataset:
Grenselandet mellom yrkesetikk og god klinisk praksis – en kasuistikk

English summary The boundary between professional ethics and good practice Nor Tannlegeforen Tid. 2025; 135: 360-5. The authors describe a case in which a patient sought dental treatment for aesthetic correction of an asymmetric midline, proximal discoloration (11. 21), and tooth shape issues in the anterior maxilla. This case is presented from four perspectives: the patient’s perception of the treatment situation, the specialist clinic at the Department of Clinical Dentistry at the University of Bergen that reviewed the treatment, the expert assessment from the Norwegian National Patient Complaint Board (NPE), and the decision made by the Vestland County Governor, who oversees patient complaints. The dentist provided extensive irreversible treatment, preparing and cementing full crowns on eight teeth (14–24). No X-rays were taken before or after the treatment. The outcome failed to meet the patient's aesthetic or functional needs. This case study illustrates how a lack of professional ethics and adherence to sound clinical practice can adversely affect a patient’s health, well-being, and financial stability.

Topic: linguistics and terminology studies
Subfield: Language and Linguistics
Field: Arts and Humanities
Domain: Social Sciences
ATRT-20. ATYPICAL TERATOID RHABDOID TUMOR: ASSOCIATION OF CLINICAL, HISTOLOGICAL, RADIOLOGICAL, MOLECULAR, AND THERAPEUTIC DATA WITH THE SURVIVAL OF PATIENTS ATTENDED AT IOP/GRAACC/UNIFESP

Abstract BACKGROUND In childhood, Atypical Rhabdoid Teratoid Tumor accounts for 2% of cases of brain tumors. There is no consensus for the treatment, resulting in multiple protocols. METHODS Retrospective study at the Institute of Pediatric Oncology-IOP/GRAACC/UNIFESP, from January 2000 to December 2022. There were 31 patients admitted during this period. The classification of the histological type into rhabdoid/classic, small round and blue cells, epithelial, and mesenchymal was carried out by the same pathologist, and a 50% cutoff characterized the predominant pattern. A neuro-radiologist reviewed the radiological data. Molecular analysis was performed using NGS. RESULTS In patients &amp;lt;3yo, 74.9% of patients died. Overall survival (OS) at 3 years was 24.5%, and progression-free survival (PFS) at 3 years was 13.8%. In patients &amp;lt;3yo, the absence of metastases was associated with a higher OS and PFS (3y-OS 35.6% and 3y-PFS 23.7%, vs 3y-OS 10% and 3y-PFS 0% in patients with M+). The OS was higher in patients who received radiotherapy at the first treatment (3y-OS of 66.6% vs 7.8% in the non-irradiated group). The classic histological pattern had a lower PFS than the epithelial and small cell groups (p=0.021). In patients&amp;gt;3 yo, 57.1% of patients died. The 3y-OS was 38.1% and the 3y-PFS was 53.5%. In this age group, there was no difference in OS and PFS considering metastases, location, histological pattern, and tumor volume. For post-surgical status, only PFS was significantly higher in patients with complete resection (3y-PFS of 75%, p=0.008). The mean survival time in patients &amp;lt;3 yo was 1.9 years, and the mean survival time in patients &amp;gt;3 yo was 2.5 years. The genetic alterations found were SMARCB1, NOTCH1, and KMT2D. CONCLUSION Patients &amp;gt;3yo seem to have a higher OS and PFS than those &amp;lt;3 yo. Early diagnosis of ATRT may corroborate to a better outcome. The radiotherapy in the first treatment can improve the outcome of patients under 3 years of age. The classic histological pattern was associated with worse PFS.

Topic: Chromatin Remodeling and Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Hubungan Percaya Diri dan Harga Diri dengan Kemampuan Bergaul Mahasiswa

The purpose of this research was to find out the correlation between self-confidence and self-esteem both individually and collectivelly and the interpersonal relationship ability. The subjects were 100 students of educational faculty of IKIP Ujung Pandang. The data were obtained by applying a set of scales for revealing interpersonal relationship, self-confidence, and self-esteem. The data were subjected to regression and analysis of variance. Based on the data analysis, it was concluded that the ability in interpersonal relationship was influenced by the students` self-confidence and students' self-esteem. Furthermore, self-confidence had a greater influence than self-esteem on ability in interpersonal relationship

Topic: Student Stress and Coping
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Holistic, person-centred care is vital for people living with cancer

Four months ago, I began my role as chief nursing officer (CNO) at Macmillan Cancer Support (MCS). This is a joint leadership position, which I share with our chief medical officer Richard Simcock. Alongside this, I continue to work part time as a nurse consultant so that I can remain clinically informed and up-to-date with professional issues that affect our ability as nurses to provide high-quality care.

Topic: Palliative Care and End-of-Life Issues
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
[Glomus tumor as a cause of coccygodynia].

Painful glomus tumors near the coccyx have not yet been described before. Three patients with coccygodynia were treated by excision of the glomus coccygeum. All of them were free of pain afterwards. Two glomus tumors were found. The tumors of the glomus coccygeum are compared with the well-known glomus tumors "Masson".

Topic: Soft tissue tumors and treatment
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Related Article from Identification of Modulated Genes by Three Classes of Chemopreventive Agents at Preneoplastic Stages in a p53-Null Mouse Mammary Tumor Model

Related Article from Identification of Modulated Genes by Three Classes of Chemopreventive Agents at Preneoplastic Stages in a p53-Null Mouse Mammary Tumor Model

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A Method of Detecting Abnormal Signals using Statistical Analysis for Residual Sequence of AR Model Estimation Error.

逐次最尤推定法による自己回帰モデルの推定残差列統計量解析を用いたプロセス異常信号の検出法を開発した.本手法は, 逐次最尤推定法によりプロセス信号を自己回帰モデルに近似し, モデルの推定残差列から対数尤度関数と自己相関関数の二乗和を用いて白色性の検定を行い, 異常信号を検出する.本手法の有効性を確認するため, 直鎖状低密度ポリエチレン製造装置触媒供給系での触媒流量異常信号の検出に適用した.その結果, 本手法は異常信号の検出に有効であることがわかった.

Topic: Engineering Diagnostics and Reliability
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Effects of different temperatures and diets on nutritional and bio‐functional components in the juvenile lined seahorse (<i>Hippocampus erectus</i>)

Abstract A two‐factorial experiment (temperature with three levels: 23°C, 25.5°C and 28°C; diet with four kinds: live Artemia sp., copepods, live Artemia sp. + copepods and frozen Neomysis awatschensis [FNA]) was carried out to evaluate the effects of different temperatures and diets on biochemistry in the juvenile lined seahorse ( Hippocampus erectus ) for thirty days. The juveniles ( n = 1260, body height: 5.1 ± 0.48 cm, initial wet weight: 0.42 ± 0.14 g) were distributed in 36 experimental aquaria (35 individuals each). Each treatment had 3 replicates. On day 30, the seahorses were vacuum freeze‐dried at −56°C before chemical analysis. Amino acids, fatty acids, Se, Zn, nucleosides, and nucleotides were measured in the present study. The results show that temperature, diet, and their interaction significantly affected all components. The content of amino acids and fatty acids in the juveniles fed FNA at 23°C was the highest. The content of Zn in the juveniles fed FNA at 23°C, and the content of Se fed Artemia sp. + copepod at 25.5°C were the highest, respectively. The content of uracil, adenine, and thymidine in the juveniles at 23°C was significantly lower than those treatments at 25.5°C and 28°C. The levels of uracil, guanine, cytosine, uridine, and guanosine at 28°C were significantly higher than those at 23°C or 25.5°C when fed Artemia sp. + copepod. The juveniles fed Artemia sp. + copepod and Artemia sp. at 28°C has the highest comprehensive scores of nucleoside and nucleotide. In conclusion, FNA is the best feed to improve the content of amino acids, fatty acids, and Zn at 23°C.

Topic: Aquatic life and conservation
Subfield: Aquatic Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Variation in plastid genomes and transcriptomes in the gynodioecious species Silene vulgaris

<title>Abstract</title> Background Gynodioecious species exist in two genders – male-sterile females and hermaphrodites. Male sterility in higher plants often results from mitonuclear interaction between the CMS (cytoplasmic male sterility) gene(s) encoded by mitochondrial genome and by nuclear-encoded restorer genes. Mitochondrial and nuclear-encoded transcriptomes in females and hermaphrodites are intensively studied, but little is known about gender-specific gene expression in plastids. We have compared plastid transcriptomes between females and hermaphrodites in two haplotypes of a gynodioecious species Silene vulgaris with known CMS candidate genes. Results We generated complete plastid genome sequences from five haplotypes S. vulgaris including the haplotypes KRA and KOV, for which complete mitochondrial genome sequences were already published. We constructed a phylogenetic tree based on plastid sequences of S. vulgaris. Whereas lowland S. vulgaris haplotypes including KRA and KOV clustered together, the accessions from high European mountains diverged early in the phylogram. S. vulgaris belongs among Silene species with slowly evolving plastid genomes, but we still detected 212 substitutions and 112 indels between two accessions of this species. We estimated elevated Ka/Ks in the ndhF gene, which may reflect the adaptation of S. vulgaris to high altitudes, or relaxed selection. We compared depth of coverage and editing rates between female and hermaphrodite plastid transcriptomes and found no significant differences between the two genders. We identified 51 unique C to U editing sites in the plastid genomes of S. vulgaris, 38 of them in protein coding regions, 2 in introns, and 11 in intergenic regions. The editing site in the psbZ gene was edited only in one of two plastid genomes under study. Conclusions We revealed no significant differences between the genders in plastid transcriptomes of two haplotypes of S. vulgaris. It suggests that gene expression of plastid genes is not affected by CMS in flower buds of S. vulgaris, although both genders may still differ in plastid gene expression in specific tissues. We revealed the difference between the plastid transcriptomes of two S. vulgaris haplotypes in editing rate and in the coverage of several antisense transcripts. Our results document the variation in plastid genomes and transcriptomes in S. vulgaris.

Topic: Plant Diversity and Evolution
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Comparison of serum troponin level and echocardiographic parameters between male and femal patients with ACS

Background: Acute Coronary Syndrome is one of the commonly diagnosed life threatening condition as of now. Hence it is necessary to diagnose early and assess the severity of disease as soon as possible. Troponin is considered a specific marker for the diagnosis of acute coronary syndrome (ACS). Aim: To estimate the high-sensitivity cardiac troponin (hs-cTn) in Acute coronary syndrome patients. Also to compare serum troponin levels and echocardiographic parameter in patient's gender. Materials and Methods: 70 patients of both sexes who got admitted within 24 hours after onset of symptoms and diagnosed as Acute Coronary Syndrome in Hospital of Baghdad /medical city during the period of December 2020 to December 2021. The (hs-cTn) was measure in the blood with Elisa Assay kit. Results: This study included 70 patients, they divided into two groups: Male group and female group. The control group included 20 healthy persons. There was a significant increase in the frequency of ACS among males in comparison to females (P-value =0.0027). The mean (± SEM) value of serum hs-troponin I concentrations did not differ significantly (p=0.372) as compared with mean (± SEM) value of serum control group.

Topic: Acute Myocardial Infarction Research
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Diffusive motions in living cytoplasm probed by laser Doppler microscopy

SUMMARY We have examined cytoplasmic motions in growing pollen tube tips using laser Doppler microscopy, a non‐invasive and non‐destructive technique. The observed correlation functions were consistent with the existence of diffusive motions in the tip cytoplasm. Further analysis of the data revealed the existence of at least two major and a third, minor, diffusing species in the cytoplasm. Information from quantitative electron microscopy and from published literature values of cytoplasmic viscosity was used to tentatively identify the organelles contributing to the observed diffusive motions. It is concluded that motions of mitochondria and secretory vesicles dominate the observed correlation functions with a minor component detected from either ribosomes or the microfilament network. Sources of variation in the observed data are discussed, as are the physical limitations that prevent a more positive analysis of the present data.

Topic: Plant Reproductive Biology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Extracorporeal shock wave lithotripsy of biliary and pancreatic stones

textabstractThe aim of the study was to answer the following questions:
Is extracorporeal shock wave lithotripsy for gallbladder stones a safe and effective therapy?
(Chapter 2)
Is simultaneous treatment with extracorporeal shock wave lithotripsy and the solvent methyl
te.rt-butyl ether feasible, safe. and more effective than either treatment alone? (Chapter 3)
Is ultrasonography reliable for the evaluation of ESWL-results? (Chapter 4)
What proportion of patients, with symptomatic gallbladder stones, is suitable for the current
operative and non-operative treatment modalities? (Chapter 5)
Is stone recurrence inevitable after gallbladder saving therapies? (Chapter 6)
Is extracorporeal shock wave lithotripsy a safe and effective therapy for common bile duct
stones? (Chapter 7)
Is extracorporeal shock wave lithotripsy a safe and effective therapy for pancreatic duct
stones? (Chapter 8)

Topic: Kidney Stones and Urolithiasis Treatments
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
THE TWO GREAT COMMANDMENTS IN THE TESTAMENTS OF THE TWELVE PATRIARCHS

L'a. cherche a montrer la complexite de l'etude des Pseudepigraphes de l'Ancien Testament et la prudence dont il faut faire preuve. S'appuyant sur le traitement des deux premiers commandements dans le Testament des Douze Patriarches, il etablit que, contrairement aux affirmations de R.H. Charles, il est impossible de dissocier d'eventuelles interpolations chretiennes du fond juif. L'etude de l'histoire de la transmission des Pseudepigraphes a convaincu l'a. de considerer les Pseudepigraphes de l'Ancien Testament avant tout comme litterature chretienne.

Topic: Biblical Studies and Interpretation
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Adults in Involuntary Career Transition: An Analysis of the Relationship Between the Psychological and Career Domains

This investigation examined the relationship between psychological and career domains in a sample of 371 involuntarily laid off workers in the midwestern United States. The psychological domain was operationalized using the NEO Five Factor Inventory. The Career Transitions Inventory was used to examine internal psychological resources which adults may assess when making a career transition. A latent variable model was developed between the two sets of constructs to explore the possible direct relationships between these sets. The results indicated that neuroticism and openness to experience explained a significant amount of variance in the career transition variables. Self-efficacy was found to be predicted by four of the five personality factors. Implications concerning the importance of assessing underlying personality traits as well as more specific career constructs are discussed. In addition, the implications of these data for the greater integration of the psychological and career domains within our training programs is also highlighted.

Topic: Career Development and Diversity
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
Additional file 1 of Are radiomics features universally applicable to different organs?

Additional file 1: Supplementary Table 1. Definition of extracted radiomics features. Supplementary Methods. Patients and imaging datasets. Imaging differences at the organ level. Supplementary Results. Fig. S1. The Kaplan-Meier plots using the radiomics score based on test set2 (kidney). Fig. S2. The Kaplan-Meier plots using the radiomics score based on test set2 (brain).

Topic: Radiomics and Machine Learning in Medical Imaging
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Supplementary Figures from Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

&lt;p&gt;SF1:Super-enhancer profiling identifies three subtypes of LUSC. SF2: Brn2 is expressed in a subset of human primary LUSC tumors. SF3: Brn2 and Sox2 co-localize and collaborate in the 'neural' LUSC cells. SF4: DNp63 overexpression in the 'neural' LUSC cells suppresses Brn2 expression and induces phenotypic changes. SF5: Brn2 overexpression and p63 ablation in the 'classical' LUSC cells and Brn2 ablation in the 'neural' LUSC cells. SF6: DNp63 induces a classical squamous-cell transcriptional program and G1 phase arrest in the 'neural' LK2 cells. SF7: DNp63 suppresses the 'neural' lineage program and induces the classical squamous-cell transcriptional program. SF8: DNp63 alters ErbB family signaling in the 'neural' LK2 cells.&lt;/p&gt;

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Adrenal insufficiency in a general hospital over a 14-year period.

Over a 14-year period, 26 patients with adrenal insufficiency of multiple etiology were evaluated. Eight were diagnosed at autopsy, six of whom had acute bilateral adrenal hemorrhage. Nine had chronic adrenal insufficiency. Of these, five were idiopathic and three had polyglandular disorders. Four others had tuberculosis. Six of nine patients with chronic adrenal insufficiency were hyperpigmented. Unusual manifestations of adrenal hypocorticism included hypercalcemia, flaccid paralysis, and joint contractures. The presence of multiple hormonal deficiencies focused the diagnosis on hypopituitarism. Two cases of isolated ACTH deficiency were detected. Patients with familial Mediterranean fever with amyloidosis commonly presented with reduced adrenal reserve rather than overt insufficiency. Metastatic cancer of the adrenal glands was a rare cause of reduced adrenal reserve.

Topic: Adrenal Hormones and Disorders
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Applying Advanced Ground-Based Remote Sensing in the Southeast Asian Maritime Continent to Characterize Regional Proficiencies in Smoke Transport Modeling

ABSTRACT This work describes some of the most extensive ground-based observations of the aerosol profile collected in Southeast Asia to date, highlighting the challenges in simulating these observations with a mesoscale perspective. An 84-h WRF Model coupled with chemistry (WRF-Chem) mesoscale simulation of smoke particle transport at Kuching, Malaysia, in the southern Maritime Continent of Southeast Asia is evaluated relative to a unique collection of continuous ground-based lidar, sun photometer, and 4-h radiosonde profiling. The period was marked by relatively dry conditions, allowing smoke layers transported to the site unperturbed by wet deposition to be common regionally. The model depiction is reasonable overall. Core thermodynamics, including land/sea-breeze structure, are well resolved. Total model smoke extinction and, by proxy, mass concentration are low relative to observation. Smoke emissions source products are likely low because of undersampling of fires in infrared sun-synchronous satellite products, which is exacerbated regionally by endemic low-level cloud cover. Differences are identified between the model mass profile and the lidar profile, particularly during periods of afternoon convective mixing. A static smoke mass injection height parameterized for this study potentially influences this result. The model does not resolve the convective mixing of aerosol particles into the lower free troposphere or the enhancement of near-surface extinction from nighttime cooling and hygroscopic effects.

Topic: Atmospheric chemistry and aerosols
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Gas formation mechanism of marine carbonate source rocks in China

By breaking through the conventional ideology on the study of gas-formation mechanism of source rocks which focused on merely the characteristics of source rocks themselves, and based on the development and distribution characteristics of marine carbonate source rocks in the medium-to-bottom parts of the Chinese superimposed sedimentary basins as well as various processes in the course of gas generation and reservoir forming, the complex hydrocarbon-gene rating model of carbonates is established. Such a model concerns not only the "three-stage" gas formation characteristics of carbonates, but also the gas generation process due to a thermal cracking of oil and the re-generation process of gas from heated secondary organic matters during the gas-generation and reservoir-forming course. The high-quality hydrocarbon generating matter of marine carbonate source rocks determined a high gas-oil ratio and tended to form paleo-oil-reservoirs, representing an enrichment process of organic matters. The thermal cracking of oil in palaeo-oil-reservoirs is an important means for the effective formation of gas reservoirs. The secondary organic matters in carbonate reservoirs may regenerate gas after a secondary deep burial, thus becoming an effective gas source.

Topic: Hydrocarbon exploration and reservoir analysis
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
Development and Characterisation of Phenolic Resin Moulding Materials for the Production of New Short Fibre-Reinforced C/C-SiC Composites

This article focuses on the development of phenolic resin moulding materials for the production of new carbon fibre-reinforced ceramic composite materials based on C/C-SiC by utilising the LSI (liquid silicon infiltration) production method. The production of these moulding materials is being accomplished by combining phenolic resin and carbon fibres with the addition of a few selected parts of processing aids, during which the influence of the used lubricants on the processability of the moulding materials is examined. The starting materials, microstructures and mechanical properties of the materials were characterised at every step of the entire process (CFRP and C/C composites) as well as the end of the whole production (C/C-SiC composites). During this investigation a link between the portions of the lubricant used, the forming of the porosity and the impact on the mechanical properties was discovered. In regards to the optimisation of the process the involved parties were able to determine an optimal lubricant ratio.

Topic: Additive Manufacturing and 3D Printing Technologies
Subfield: Automotive Engineering
Field: Engineering
Domain: Physical Sciences