jimnoneill/paper-to-field-training huggingface dataset:
ASSOCIATION OF NON-HISTONE PROTEINS INDUCED BY ANTIGEN WITH ACTIVE CHROMATIN

Conference Abstract| April 01 1981 ASSOCIATION OF NON-HISTONE PROTEINS INDUCED BY ANTIGEN WITH ACTIVE CHROMATIN E. M. Rakowicz-Szulczynska E. M. Rakowicz-Szulczynska 1Institute of Human Genetics, Polish Academy of Sciences, Swiecickiego 6,60-781, Poznań, Poland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 129P. https://doi.org/10.1042/bst009129pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation E. M. Rakowicz-Szulczynska; ASSOCIATION OF NON-HISTONE PROTEINS INDUCED BY ANTIGEN WITH ACTIVE CHROMATIN. Biochem Soc Trans 1 April 1981; 9 (2): 129P. doi: https://doi.org/10.1042/bst009129pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Genomics and Chromatin Dynamics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Speed of onset of regional analgesia in labour: a comparison of the epidural and spinal routes

This study compares the speed of onset of effective analgesia in two randomly assigned groups of patients requesting analgesia in labour. Patients in the combined spinal–epidural group ( n = 69) were given a subarachnoid injection of 1.5 ml containing bupivacaine 2.5 mg and fentanyl 25 μ g for initiation of analgesia. Patients in the epidural group ( n = 73) were given an epidural injection of 10 ml containing bupivacaine 12.5 mg and fentanyl 50 μ g. Mean (SD) onset times to the first pain‐free contraction were 10.0 (5.7) min in the combined spinal–epidural group and 12.1 (6.5) min in the epidural group (p = 0.054). Patients in the combined spinal–epidural group suffered a higher incidence of motor weakness and proprioceptive deficit than those in the epidural group (p = 0.01). The incidence of technique failure and side‐effects was similar in the two groups. It is our contention that the statistically nonsignificant difference in onset times does not justify the additional potential for side‐effects and the extra cost of the equipment involved in the combined spinal–epidural technique.

Topic: Anesthesia and Pain Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Evaluation of Learning Teams Versus Root Cause Analysis for Incident Investigation in a Large United Kingdom National Health Service Hospital

Introduction Significant resource is invested into investigation of adverse healthcare events. Outcomes of such investigations have varying degrees of effectiveness. The “hierarchy of effectiveness” model proposes system-focused changes have greater impact than person-focused actions. The traditional approach to investigation is root cause analysis (RCA); however, such an approach does not prioritize system-focused action generation. Learning team-based investigations are thought to generate more effective system-focused actions; however, this has not been evaluated. Methods Retrospective mixed methods evaluation of learning teams compared with RCA. Twenty-two learning team investigations compared with 22 RCA investigations, with quantitative assessment of the number of system-focused and person-focused actions generated. Assignment of the two different methods to incidents was not random, with learning teams being selected for cases, which were initially judged to be process-focused problems. Semistructured interviews were conducted with four learning team facilitators with thematic analysis to identify causes for outcome variations. Results Learning team investigations yielded a median of 7.5 actions compared with 3.5 actions for RCA: 57% of learning team actions were system focused versus 30% for RCA. We identified variations in personnel involved, culture of the investigation, and differences in the investigative approaches as potential drivers for these differences. Conclusions We observed that learning team investigations that targeted process-focused problems generated more actions and a higher number of system-focused actions. There is a difference in culture created during learning team investigations. Although learning teams are not suitable for all investigations, they represent a readily reproducible and valuable addition to the investigative toolkit.

Topic: Patient Safety and Medication Errors
Subfield: Emergency Medical Services
Field: Health Professions
Domain: Health Sciences
Reduction of Nitrate and Acrylamide in Cereal Baking Using Lactobacillus casei and Herbal Extracts

Background: Nitrate and acrylamide as carcinogenic substances are increased during the baking process of foods, such as cereals. Objective: This study aimed to reduce the amount of acrylamide and nitrate in three types of cereals, wheat, barley, and maize, by treatment with probiotic bacteria and several plant extracts. Methods: Three types of plant extracts were prepared from Coriandrum sativum, Nigella sativa, and Thymus sp. leaves and stem. Also, Lactobacillus casei subspecies rhamnosus LCR6013 was used as probiotic bacteria for bacterial treatment. Acrylamide and nitrate were measured by HPLC and UV-vis spectrophotometry. Results: Adding plant extracts and LCR 6013 bacteria could reduce the level of nitrate and acrylamide in the cereal samples. Among plant extracts, nigella could reduce nitrate in all samples below detectable levels. Also, it was effective in reducing acrylamide content from samples to the extent of 87% in barley, 60% in wheat, and 100% in corn. Bacterial treatment could also reduce nitrate levels between 70 and 100% while having a variable impact on decreasing acrylamide. Oneway analysis of variance (ANOVA) was used to determine statistically significant results. Conclusion: It was concluded that pre-baking exposure to plant extract and bacteria is effective in the reduction of nitrate and acrylamide quantity in the heat processing of cereals.

Topic: Potato Plant Research
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Experimental Measurement of Competitive Ion-Induced and Binary Homogeneous Nucleation in SO<sub>2</sub>/H<sub>2</sub>O/N<sub>2</sub>Mixtures

Alpha-ray radiolysis of SO₂/H₂O/N₂ gas mixtures is carried out to investigate the competitive processes of ion-induced and binary homogeneous nucleation in this system. Charged particles in the system are indicative of ion-induced nucleation and most likely involve water clusters. Charged particle neutralization was prevented by application of a dc electric field, therefore, uncharged particles in the system result from homogeneous nucleation. Hydroxyl (OH) radicals are generated by the a-ray radiolysis. Oxidation of SO₂ by OH radicals leads to sulfuric acid (H₂SO₄) vapor molecules and to subsequent binary homogeneous nucleation of H₂SO₄/H₂O. At increased SO₂ concentrations the contribution of binary homogeneous nucleation increases relative to that of ion-induced nucleation. Electrical mobility distributions of bipolar ions and nanometer-sized charged particles were measured with a cluster-differential mobility analyzer combined with a Faraday cup electrometer. In this system, ion-induced nucleation occurred preferentially on negative rather than positive ions.

Topic: nanoparticles nucleation surface interactions
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Genomics in the real world.

The term genomics has evolved into a catch-all term for a variety of information intensive biological methodologies. While the promise of genomics in the bio/pharmaceutical industry is great, its impact on the drug discovery pipeline has not yet been realized, excluding a few notable exceptions. As companies acquire several years of experience in working with genomic data, it is likely that the impact on the discovery process will slowly emerge as we learn to integrate these new technologies into individual discovery programs. It is clear that extracting novel biologically valid targets targets from exponentially growing amounts of sequence data requires time and considerable investment in biological research infrastructure. In order to accelerate the process of target validation, a variety of functional genomics technologies are also being developed to try to predict the effect of inhibitory compounds in advance of development. Resources spent on early stage exploratory efforts such as these can pay off by improving the success rate for screening and medicinal chemistry.

Topic: Genetics, Bioinformatics, and Biomedical Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Developing a 3D model viewer for iOS using COLLADA and OpenGL ES

This hands-on, interactive studio course delivers a native iOS app built from scratch, with powerful 3D graphics technologies from the Khronos Group. We explore the latest Xcode IDE and SDK frameworks available to develop the skills and learn the tools needed to make an engaging, mobile, 3D model viewer.

Topic: Augmented Reality Applications
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
The Fractional Covariance

Abstract This is the first of three chapters that deal with the distribution of the covariance between the nonstationary partial sums of a fractional process and a stationary fractional process. This is motivated by the role of expressions of this kind arising in cointegration models, that is to say, regressions with nonstationary partial sum processes and a stationary disturbance. The chapter has five sections. Section 1 sets up a bivariate framework with assumptions on the shock processes and proves a law of large numbers and a central limit theorem for the products of a fractional pair. In Section 2 a decomposition of the covariance is constructed, separating it into terms having means of zero and a ‘mean term’ whose mean is the same as that of the covariance. The remainder of this chapter analyses this ‘mean term’. The large-sample limit of the expected value is derived under various assumptions on the d parameters. Section 3 deals with the long memory case and derives a closed form for the expectation and Section 4 deals with the antipersistent case. In Section 5, a law of large numbers is proved, showing that with suitable normalization the ‘mean term’ does converge in mean square to the limiting expected value.

Topic: Financial Risk and Volatility Modeling
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Reviewer #2 (Public Review): Mitochondrial temperature homeostasis resists external metabolic stresses

Based on studies with a fluorescent reporter dye, Mito Thermo Yellow, and the genetically encoded gTEMP ratiometric fluorescent temperature indicator targeted to mitochondria, the temperature of active mitochondria in four mammalian and one insect cell-line was estimated to be up to 15 °C above that of the external environment to which the cells were exposed. High mitochondrial temperature was maintained in the face of a variety of metabolic stresses, including substrate starvation or modification, decreased ATP demand due to inhibition of cytosolic protein synthesis, inhibition of the mitochondrial adenine nucleotide transporter and, if an auxiliary pathway for electron transfer was available via the alternative oxidase, even respiratory poisons acting downstream of complex I. We propose that the high temperature of active mitochondria is an inescapable consequence of the biochemistry of oxidative phosphorylation and is homeostatically maintained as a primary feature of mitochondrial metabolism.Mitochondria are at least 15 °C hotter than their external environment in living cells. In response to diverse metabolic stresses, mitochondrial temperature re-adjusts to this value whenever possible.

Topic: Mitochondrial Function and Pathology
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Phaseolus vulgaris cytoplasmic leucyl-tRNA synthetase. Purification and comparison of its catalytic, structural, and immunological properties with those of the chloroplastic enzyme.

The cytoplasmic leucyl-tRNA synthetase was purified from bean (Phaseolus vulgaris) leaves. After ammonium sulfate fractionation and chromatography on Sephadex G-50, DEAE-cellulose, hydroxylapatite, and phosphocellulose, complete purification was achieved by blue Sepharose CL-6B chromatography using specific elution with pure yeast tRNALeu1. The enzyme was purified 1050-fold and had a specific activity of 940 nmol of leucyl-tRNA formed/min/mg of protein. Polyacrylamide gel electrophoresis of the native enzyme showed one band, but the denatured enzyme showed two bands. These two protein bands are structurally related. The smallest protein appears to be a cleavage product from the largest one, suggesting the presence of a sensitive cleavage site in the cytoplasmic leucyl-tRNA synthetase. The cytoplasmic enzyme is a monomer (Mr = 130,000), larger than its chloroplastic counterpart (Mr = 120,000). The two enzymes differ in their substrate (tRNA) specificity, tryptic peptide map, and amino acid composition. Antibodies were raised against the cytoplasmic enzyme and against the chloroplastic enzyme and no cross-immunological reaction was detected, showing that the two enzymes do not share any antigenic determinant. Taken together, these results suggest that P. vulgaris cytoplasmic and chloroplastic leucyl-tRNA synthetases are coded for by different genes.

Topic: RNA and protein synthesis mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Septic osteoarthritis of the hip with acetabular involvement in children. Value of x-ray computed tomography].

The authors reported a case of osteomyelitis of the acetabulum associated with a septic hip arthritis in an eight year old child. They confirmed the difficulties of the diagnosis of this rare disease, and they pointed out the importance of tomographic scan (CT scan).

Topic: Orthopedic Infections and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Electronic Means for Human Reources Research

During the past several decades the increasing complexity of problem solving by individuals and institutions (both public and private) has emphasized the importance of information: its acquisition, processing and use. The rapid development of technology has provided new options for generating, processing and distributing data-increasing individual and collective awareness with concomitant with clerical functions have been entrusted with new definitions. New vocations based on the applications of data and knowledge have emerged. These developments have challenged and continue to challenge institutions in their charge to prepare individuals for such vocations.

Topic: Competency Development and Evaluation
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Comparisons of Shredded Newspaper and Wheat Straw as Crop Mulches

This study compared shredded newspaper, wheat straw ( Triticum aestivum L.) mulch, and bare soil as surface treatments under sweet corn [ Zea mays L., var. Saccharata (Surt.)], field corn ( Z. mays L.), soybean [ Glycine max (L.) Merr.], and processing tomatoes ( Lycopersicon esculentum Mill.). In a replicated study with limited mechanical weed control and no chemical weed control in 1990, and no weed control except for the mulch in 1991, the mulches provided a cooler, moister soil environment and effective suppression of most annual and some perennial weeds. The rank order of yields was the same for all three crops in 1990: newspaper mulch &gt; wheat straw mulch &gt; bare soil cover. In 1991 the rank order for yield was: soybeans/newspaper mulch &gt; wheat straw &gt; bare soil ( P &lt; 0.01); field corn/newspaper mulch &gt; bare soil &gt; wheat straw ( P &gt; 0.10). The straw and newspaper mulches had similar effects on yield, weed control, soil moisture, and soil temperature. They were significantly different from bare soil in many crop and mulch combinations studied. A brief evaluation of high rates of newspaper mulch showed no apparent growth problems for corn and soybeans and no heavy metal accumulation in the soil. Since shredded newspaper from community recycling programs in available at low cost ($40-50/ton vs. $90-100/ton for straw), this material is an attractive soil-management alternative in horticultural and agronomic production systems.

Topic: Plant Disease Management Techniques
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Single‐Crystalline Scroll‐Type Nanotube Arrays of Copper Hydroxide Synthesized at Room Temperature

A novel nanolayer‐rolled tubular structure of Cu(OH) 2 has been grown in solution at ambient temperature and pressure. Significantly, the Cu(OH) 2 nanotubes are phase‐pure single crystallites and are arrayed uniformly on copper substrates (see Figure). The reaction conditions for the fabrication of the nanotube arrays are examined and possible growth mechanisms are discussed.

Topic: Copper-based nanomaterials and applications
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Research on Risk Management of International Convention and Exhibition Industry

The rapid development of the economy and the further opening up to the outside world, as well as the country in the industrial structure adjustment continued to force, the exhibition industry ushered in the development of the spring.Every industry in the process of rapid development will encounter problems, and faced with no experience can learn from the plight.Opportunities and risks are always co-exist, in the management process if the risk can be effectively grasp, then the development of enterprises will be flourishing, on the contrary will go to a dead end.In this paper, the risk management of international exhibition industry for a brief description of the current situation.Exhibition as a special major economic and trade activities, people, logistics, information flow is highly concentrated, is a risk-sensitive industries.Exhibition risk refers to the impact of exhibitors, professional visitors, related media and other stakeholders on the exhibition of confidence or disturb the exhibition organizers continue to normal operation of the unexpected events, exhibition work in the security risks long way to go.

Topic: Conferences and Exhibitions Management
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Supplementary figure legends from CRISPR/Cas9-Mediated &lt;i&gt;Trp53&lt;/i&gt; and &lt;i&gt;Brca2&lt;/i&gt; Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

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Topic: CRISPR and Genetic Engineering
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Cross-functional integration in sustainability-driven business practice

This chapter investigates the role of cross-functional integration in sustainability-driven business practice. This vital aspect of sustainability is under-developed in available sources, particularly with reference to how practice integration can be successfully implemented. The emphasis in this chapter, which has shaped the selection of the literature and business examples, is on the environmental pillar of sustainable business practice. The examination is a critique of the strengths and weaknesses of extant knowledge. The specific research question concerns the state of knowledge about sustainability integration among the dimensions of human resources, production, and operations and supply chain management. This chapter develops a conceptual framework for studying this integration problem as a basis for extending to multiple dimensions and functions of a business. Cross-functional integration is a management task in which managers and employees design and implement integration. Illustrative cases emphasize Walmart and Recreational Equipment Inc. (REI).

Topic: Sustainable Supply Chain Management
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
The Effectiveness of Skin Perfusion Pressure Measurements during Endovascular Therapy in Determining the Endpoint in Critical Limb Ischemia

A 78-year-old man had right foot ulceration. The skin perfusion pressure (SPP) at the dorsum was 12 mmHg. Angiography revealed right iliac artery occlusion and diffuse stenosis of right superficial femoral artery. After stenting of the iliac arteries, the SPP was still 23 mmHg. Hence, we also inserted stents in the right superficial femoral artery. The anterior tibial artery remained stenosed, and the posterior tibial and fibular arteries were occluded. However, as the SPP had increased to 46 mmHg the treatment was discontinued. The ulcers improved. Measurement of SPP during a procedure may be useful in determining the treatment endpoint.

Topic: Peripheral Artery Disease Management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Chromatic Aberration Effect in Refraction of Spin Waves

We numerically investigated the refraction property of spin waves (SWs) at thickness step in films with out-of-plane magnetization, in which the SWs propagate isotropically in the film plane. It was confirmed the isotropic SWs were refracted at a thickness step by following the Snell's law. We also found that the refraction angle of SWs of the dipole-exchange mode depends on the resonant frequency, indicating that the chromatic aberration effect should be taken into account in designing magnonic devices.

Topic: Magnetic properties of thin films
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Creep and recovery in dense suspensions of smooth and rough colloids

We report the effect of particle surface roughness on creep deformation and subsequent strain recovery in dense colloidal suspensions. The suspensions are composed of hard-spherelike poly(methyl methacrylate) smooth (S) and rough (R) colloids with particle volume fractions ϕS = 0.64 ± 0.01 and ϕR = 0.56 ± 0.01, corresponding to a distance of 3.0% and 3.4% based on their jamming volume fractions (ϕJS=0.66±0.01, ϕJR=0.58±0.01). The suspensions are subject to a range of shear stresses (0.01–0.07 Pa) above and below the yield stress values of the two suspensions (σyS=0.035Pa, σyR=0.02Pa). During creep, suspensions of rough colloids exhibit four to five times higher strain deformation compared to smooth colloids, irrespective of the applied stress. The interlocking of surface asperities in rough colloids is likely to generate a heterogeneous microstructure, favoring dynamic particle activity and percolation of strain heterogeneities, therefore resulting in higher magnitude of strain deformation and an earlier onset of steady flow. Strain recovery after the cessation of stress reveals a nonmonotonic recoverable strain for rough colloids, where the peak recoverable strain is observed near the yield stress, followed by a steep decline with increasing stress. This type of response suggests that frictional constraints between geometrically frustrated interlocking contacts can serve as particle bonds capable of higher elastic recovery but only near the yield stress. Understanding how particle roughness affects macroscopic creep and recovery is useful in designing yield stress fluids for additive manufacturing and product formulations.

Topic: Material Dynamics and Properties
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences