jimnoneill/paper-to-field-training huggingface dataset:
Changes in Cardiovascular Function in Response to Acute Caffeine Ingestion During Intense Resistance Training

The effect of caffeine (CAF) ingestion on change in cardiovascular function during resistance training is relatively unexplored, and has important implications for persons with or at risk for hypertension. PURPOSE: The primary aim was to examine the effect of CAF ingestion on change in heart rate (HR), blood pressure (BP), and other indices of cardiovascular function during resistance training. METHODS: Five resistance-trained men (mean ± SE age and body mass = 21.1 ± 2.2 yr and 87.8 ± 15.4 kg) who were regular CAF consumers participated in the study. A randomized, double-blind, crossover design was used. They completed four sets of four exercises (bench press, leg press, lat row, and shoulder press) to fatigue at 75 - 80 % one-repetition maximum. A two minute recovery was allotted between sets and exercises. Seven days apart, anhydrous CAF (6 mg/kg body weight) and placebo housed in identical capsules were ingested with water 1 h pre-exercise. HR was assessed by telemetry; whereas, systolic and diastolic BP was assessed using manual sphygomanometry. Rate pressure product (RPP) was calculated as the product of HR and SBP. All variables were recorded for 30 min before exercise, after the second set of each exercise, and every 25 min for 75 min after exercise with subjects at rest. Two-way analysis of variance with repeated measures was used to examine differences in cardiovascular function over time and treatment. RESULTS: HR, SBP, and RPP were significantly increased (p < 0.01) over time, yet no change (p > 0.05) in DBP was evident. HR increased from 69.4 ± 4.2 b/min at rest to 165.0 ± 4.4 b/min during lat row exercise, and decreased to 80.0 ± 7.1 b/min in recovery. Resting, exercise, and recovery systolic BP, HR, and RPP tended to be higher in the CAF trial versus placebo, but did not reach significance (p > 0.05). There was no treatment effect (p > 0.05) for any variable. CONCLUSION: Significant increases in indices of cardiovascular function were demonstrated in response to intense resistance training. Compared to placebo, preliminary data show no effect of a 6 mg/kg CAF dose on cardiovascular function. A larger sample size may be needed to show a significant effect of acute CAF intake on HR and BP during resistance training. This project was funded by a University Professional Development/Research, Scholarship, and Creative Activity Grant.

Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Complete genome sequence of <i>Lachancea thermotolerans</i> strain L-84 isolated from Crimean vineyards

ABSTRACT The yeast Lachancea thermotolerans of the family Saccharomycetaceae is used in winemaking to increase the acidity of wine and improve its aromatic profile. We report the complete genome sequence of L. thermotolerans strain L-84, isolated from Sauvignon grapes from a vineyard in Crimea.

Topic: Fermentation and Sensory Analysis
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Government Data Performance: The Roles of Technology, Government Capacity, and Globalization through the Effects of National Innovativeness

The availability of open, relevant, and up-to-date public data is becoming an increasingly important dimension of national competitiveness and sustainable development. It serves as a foundation for novel technologies, such as big data analytics, machine learning, and artificial intelligence, to take root and flourish, and it can help improve the quality and efficiency of government decision making and render governments more transparent and accessible to the public. Often referred as Open Government Data, or OGD, governments around the world have committed resources to constructing various OGD platforms. However, building a robust and effective OGD system has proved difficult, as the promise of OGD has not been realized fully around the world. At this important juncture, this study aims to explore the relationship between national technological and organizational capacities and environmental factor and the quality of OGD systems. In addition, national innovativeness and the degree of “globalization” in a country and their moderating effects between the predictors and OGD performance are examined. Our findings indicate strong positive effects of national technological capacity, government organization capacity, and globalization on OGD quality and a positive moderating effect of national innovativeness.

Topic: E-Government and Public Services
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Characterization of Banana SNARE Genes and Their Expression Analysis under Temperature Stress and Mutualistic and Pathogenic Fungal Colonization

SNAREs (soluble N-ethylmaleimide-sensitive-factor attachment protein receptors) are engines for almost all of the membrane fusion and exocytosis events in organism cells. In this study, we identified 84 SNARE genes from banana (Musa acuminata). Gene expression analysis revealed that the expression of MaSNAREs varied a lot in different banana organs. By analyzing their expression patterns under low temperature (4 °C), high temperature (45 °C), mutualistic fungus (Serendipita indica, Si) and fungal pathogen (Fusarium oxysporum f. sp. Cubense Tropical Race 4, FocTR4) treatments, many MaSNAREs were found to be stress responsive. For example, MaBET1d was up-regulate by both low and high temperature stresses; MaNPSN11a was up-regulated by low temperature but down-regulated by high temperature; and FocTR4 treatment up-regulated the expression of MaSYP121 but down-regulated MaVAMP72a and MaSNAP33a. Notably, the upregulation or downregulation effects of FocTR4 on the expression of some MaSNAREs could be alleviated by priorly colonized Si, suggesting that they play roles in the Si-enhanced banana wilt resistance. Foc resistance assays were performed in tobacco leaves transiently overexpressing MaSYP121, MaVAMP72a and MaSNAP33a. Results showed that transient overexpression of MaSYP121 and MaSNPA33a suppressed the penetration and spread of both Foc1 (Foc Race 1) and FocTR4 in tobacco leaves, suggesting that they play positive roles in resisting Foc infection. However, the transient overexpression of MaVAMP72a facilitated Foc infection. Our study can provide a basis for understanding the roles of MaSNAREs in the banana responses to temperature stress and mutualistic and pathogenic fungal colonization.

Topic: Cellular transport and secretion
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A unified representation of some starlike and convex harmonic functions with negative coefficients

In this paper we introduce a unified representation of starlike and convex harmonic functions with negative coefficients, related to uniformly starlike and uniformly convex analytic functions. We obtain extreme points, distortion bounds, convolution conditions and convex combinations for this family.

Topic: Analytic and geometric function theory
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Galactic Halos in MONDian Cosmological Simulations

Although the currently favoured ΛCDM model has proven to be remarkably successful on large scales (cf. WMAP results, Spergel et al. 2003), recent high-resolution N-body simulations seem to be in contradiction with observation on

Topic: Scientific Research and Discoveries
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences
The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study

Background: Fat alterations are frequent in people with HIV (PWH) and predict worse cardiometabolic outcomes. Visceral adipose tissue (VAT) is associated with ectopic fat accumulation in the liver. We aimed to investigate nonalcoholic fatty liver disease (NAFLD) diagnosed by controlled attenuation parameter (CAP) as a potential marker of visceral adiposity in PWH. Methods: We conducted a prospective pilot study of HIV mono-infected patients undergoing metabolic characterization and paired CAP measured by transient elastography with dual-energy X-ray absorptiometry (DEXA) scan. NAFLD was defined as CAP ≥ 285 dB/m, in absence of alcohol abuse. Excess visceral adiposity was defined as VAT &gt; 1.32 Kg. Pairwise correlation, area under the curve (AUC) and logistic regression analysis were employed to study the association between VAT and CAP. Results: Thirty patients were included, of whom 50% had NAFLD. CAP was correlated with VAT (r = 0.650, p &lt; 0.001) measured by DEXA scan. After adjusting for duration of HIV infection, body mass index and waist circumference, CAP remained the only independent predictor of excess VAT (adjusted odds ratio 1.05, 95% confidence interval [CI] 1.01–1.10). The AUC analysis determined CAP had excellent performance to diagnose excess VAT (AUC 0.92, 95% CI 0.81–1.00), higher than BMI and waist circumference. The optimized CAP cut-off to diagnose excess VAT was 266 dB/m, with a sensitivity of 88.3% and a specificity of 84.6%. Conclusions: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine.

Topic: Liver Disease Diagnosis and Treatment
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
[Serodiagnosis of gonorrhea].

Due to the short incubation period of gonorrhea and the persistence of antibodies for years, a serological test cannot be used as the only basis for diagnosis of acute cases or for screening purposes. Major potential fields for application are the diagnosis of complicated gonococcal infections, casefinding in "high risk" groups and sero-epidemiological studies in developing countries. Serological tests using gonococcal pili antigen seem to be superior with regard to specificity.

Topic: Virology and Viral Diseases
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
PEMBUATAN NANOPARTIKEL-PERAK EKSTRAK DAUN UBI JALAR ORANGE (Ipomoea batatas L.) DENGAN METODE BIOREDUKSI DAN UJI AKTIVITAS TERHADAP JUMLAH TROMBOSIT Mus musculus

This study aims to make silver nanoparticles (NPP) of orange Sweet potato extract (Ipomoea batatas L.) using bioreduction method and test the effect of giving silver nanoparticles - leaf extract of Ipomoea batatas L. orange (Ipomoea batatas L.) to the number of thrombocyte from male of Mus musculus induced by aspirin. The precursor used is 1 mM AgNO3 solution and as bioreductor is an antioxidant compound in orange sweet potato extract (Ipomoea batatas L.). The ratio of AgNO3 1 mM solution volume and orange sweet potato leaf extract is 9: 1 with 2 hours time. The characteristic test again obtained NPP is done using FTIR and Particle Size Analyzer (PSA) using Dynamyc Light Scattering method (DLS). The results showed that from the PSA analysis is known the average size of NPP – I. Batatas, L leaf extract is an average of 86.0 nm with a polydispersity value (PDI) of 0.17 &lt; 1 that indicates that the NPP-leaf extract particle size distribution It is less homogeneous and are less stable.The results show that the administration of silver nanoparticles - orange sweet potato extract (Ipomoea batatas L.) can increase the platelet count of male mice significantly Dose of 0.014 g / Kgbb of 259,600 / mm3.

Topic: Medicinal Plant Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Na-Doped ZnO and RGO Composite-Based Flexible Acetone Gas Sensor Operated in Room Temperature

Real-time health monitoring is important in disease prediction, prevention, and early treatment. In this study, based on Na-doped ZnO/reduced graphene oxide (RGO) heterojunction, an ultrasensitive flexible room temperature gas sensor was developed for lung cancer surveillance diagnosis. The sensing material was synthesized using a simple solution route. X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Raman spectroscopy were carried out to investigate the structure and chemical properties. The fabricated material has a surface-to-volume ratio, which was important to the sensing property. The gas-sensing performance was measured from 5 ppm to 200 ppm at room temperature (25 &#x00B0;). The proposed sensor demonstrated fast response and recovery time, as well as great repeatability and long-term stability. Furthermore, it exhibited mechanical robustness, and can be bent to different angles with almost no resistance change. Moreover, performance investigation at low acetone concentrations (0.2 ppm to 1.0 ppm) revealed its capability of distinguishing acetone gas as low as 0.2 ppm, with good linearity under different acetone concentration. As such, the developed sensor could provide a promising basis for disease monitoring through detecting the concentration of acetone gas exhaled by human.

Topic: Gas Sensing Nanomaterials and Sensors
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Denizens of Alien Worlds: A Study of Education, Inequality and Polarization in Pakistan * By TARIQ RAHMAN (Oxford: Oxford University Press, 2005), 210 pp. Price HB $14.00. ISBN 0-19-597863-3.

This book makes a well-informed contribution to our understanding of the education system in Pakistan. It will be useful to those interested in International Comparative Education, Sociology of Education and Inclusive Education. It has direct relevance for teachers, policy makers and educationalists in Pakistan and those in other countries where Pakistanis now live. Basing his argument on government data, empirical evidence, personal experience and reflexive observations, Tariq Rahman has sought to navigate the uneven, complex and multi-layered terrain facing those who wish to challenge structural inequalities in Pakistan. He demonstrates the need to improve the quality, relevance and accessibility of basic education for millions of school-age children, and thousands of students in higher education in Pakistan, particularly those who cannot access fee-paying elite educational establishments. The UNESCO Document ‘Education for All’ (1990) defines the rights of the majority of Pakistani students, and the responsibilities of those in charge of educational...

Topic: Global Educational Policies and Reforms
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Beyond the mere dichotomy of active search versus avoidance of information about the self.

Case et al.'s [1] paper—“Avoiding Versus Seeking: The Relationship of Information Seeking to Avoidance, Blunting, Coping, Dissonance, and Related Concepts”—provides a comprehensive review of seminal work on the topic of information-seeking behavior that has evolved over the last few decades. The paper is also useful for researchers wanting to promptly identify areas for future investigation.

Case et al. [1] primarily emphasize the need to further explore individuals' tendencies to avoid information. In response, we would like to raise the following issues for consideration. A call to focus attention on information avoidance behavior is timely but may perpetuate the view of information seeking as an all-or-nothing phenomenon, despite accumulating accounts that such behavior is more fluid and context-bound than previously thought [2]. Although the authors have chosen to focus on the notion of information avoidance, individuals are rarely found to either be information “avoiders” or active “seekers” across the board. Rather, individuals often are purposefully selective in the type, sources, and amount of information they seek [3–5]. A pregnant woman, for instance, may not want to be told of the sex of her fetus as it appears on an ultrasound but may be open to “folk” tales about how to tell whether the fetus is a girl or a boy. An individual with a diagnosis of cancer may be selective and seek much information on treatment options but not on prognosis. In addition, individuals attend differently to information depending on how it is presented (e.g., as facts, statistics, or testimonials).

Studies exploring these differing information-seeking behaviors and the ways these are modulated over time are few. Case et al.'s [1] examples of individuals who avoid information are informative, but they do not attempt to address how and why different information-seeking behaviors emerge in the scope of their review. Future theoretical and empirical work could address the following: Why do individuals choose to seek certain types of information and ignore others within and across situations? What are the specific features of information that prompt individuals to seek or avoid it? How do individual differences interact with context to influence distinct processes and outcomes related to information seeking about the self?

Topic: Misinformation and Its Impacts
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
[Circumflex coronary artery fistula during staphylococcal aortic valve endocarditis].

We presented a very rare case of the fistula to coronary artery during staphylococcal aortic valve endocarditis in a young man. The tranesophageal echocardiography detected vegetation on aortic valve leaflets and large regurgitatin. During transesophageal echocardiography the peri-anular multi-chamber abscess formation and fistulous communication to circumflex coronary artery was detected.

Topic: Infective Endocarditis Diagnosis and Management
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Figures S1 - S9 from BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

&lt;p&gt;Figure S1. Inducible BMX knockdown suppresses CWR22RV1 tumor growth in vitro and in vivo; Figure S2. Schematic picture of BMX signaling pathway; Figure S3. The effect of BMX SiRNA smart pool on CWR22RV1 cell response to serum stimulation; Figure S4. The specificity of BMX antibody; Figure S5. Affymetrix microarray expression of BMX in PCa patients; Figure S6. BMX mRNA expression is repressed by DHT; Figure S7. BMX knockdown in CWR22RV1 cells; Figure S8. AR binding site sequence in BMX loci; Figure S9. DHT effect on expression of AR and associated proteins.&lt;/p&gt;

Topic: Prostate Cancer Treatment and Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
High-power, high-current pseudospark switches

A low-pressure gas switch with a hollow cathode and hollow anode (pseudospark geometry) that switches an order-of-magnitude-higher current than commercially available thyratrons, over 100 kA, is reported. The switch is not a spark gap and does not form arcs at the electrodes. The cold cathode produces much higher emission than hot cathodes presently in use. The switch significantly extends the performance capabilities of switching technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Gyrotron and Vacuum Electronics Research
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
The Addition of Sulfur Atoms to Olefins

Absolute rate coefficients and Arrhenius parameters have been obtained for the cycloaddition reaction of S(3P2,1,0) atoms with a representative series of olefins and acetylenes. The activation energies are small, and they exhibit a trend with molecular structure which is expected for an electrophilic reagent. The A-factors show a definite trend which can be attributed to steric repulsions and a generalized secondary α-isotope effect explained by activated complex theory. Secondary α-H/D kinetic isotope effects have been measured and their origin discussed. Hartree-Fock type MO calculations indicate that the primary product of the S(3P) + olefin reaction is a ring-distorted, triplet state thiirane, with a considerable energy barrier with respect to rotation around the C-C bond.

Topic: Organic Chemistry Cycloaddition Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
PENGARUH TQME, GAYA KEPEMIMPINAN DAN KEDISIPLINAN KERJA TERHADAP KINERJA DOSEN

This study aim to examine influence of Total Quality Management in Education, Leadership and Labore Dicipline to Lecture Performance. Using a survey sample colected from 144 lecture who have worked at Privat University in East Java. This study was done using computer delivered surveys, mail surveys and pick up surveys data collection. The finding of the study reveal that labore dicipline has a significant influence on the lecture performance and TQME, leadership has not significant influenceon the lecture performance.The result of this study profide the conclusion that adoption of TQME and leadership will not increase lecture performance and labore dicipline will increase lecture performance.

Topic: Education and Communication Studies
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
HCV GENOTYPES AND ITS ASSOCIATION WITH RESPONSE TO TREATMENT

BACKGROUND &amp; OBJECTIVE: primary Hepatitis C is a serious public health problem and is the cause of liver cirrhosis, hepatocellular carcinoma (HCC), and numerous end-stage liver disease manifestations. The management of hepatitis C is to preclude liver cirrhosis, lessen the risk of hepatocellular carcinoma or hepatoma, and curing the extra hepatic diseases. Initially, interferon was the cornerstone for treating hepatitis C, but due to its cumbersome complications, route of administration, and limited treatment access, many patients showed noncompliance. New therapies for chronic hepatitis C have been introduced based on direct antiviral eﬀects. Several genotypes of hepatitis C have been discovered and they are responsive to diﬀerent antiviral therapies. Our objective was to assess the genotypic distribution of HCV in our local setup and their pattern of response to diﬀerent combination of anti-viral therapies by assessing the sustained viral response (SVR) after 12 weeks post-treatment. To determine the most prevalent genotype of hepatics C virus in our population and pattern of the response of multiple genotypes to diﬀerent antiviral regimens.&#x0D; METHODOLOGY: It is a cross-sectional study conducted for duration of six months and recruited those patients whose polymerase chain reaction (PCR) was found positive for hepatitis C virus at Islamabad Diagnostic Center. We analyzed 100 patients, both children and adults. Patients were assessed for diﬀerent genotypes and then diﬀerent combinations of antiviral treatments were administered. Their clinical data, hematological parameters and viral load before and after treatment were also analyzed.&#x0D; RESULTS: In a total of 100 positive hepatitis C virus-infected patients, 55% were females and 45% males. The frequencies of genotypes observed were 91 %, 06%, and 03% of genotype 3, 1a, and 1b respectively. 51 out of 91 patients with type 3 genotype, who were on antiviral therapy of sofosbuvir and ribavirin, all of them achieved SVR. 30 out of 91 patients with type 3 genotype were treated with sofosbuvir alone, the percentage of failure to achieve SVR in them was 6.7%. Treatment failure percentage of 10% was observed when a combination of Interferon (INF) alpha and ribavirin was used in type 3 genotype. Remaining six patients with type 1a and three patients of type 1b genotype achieved SVR with diﬀerent regimens used.&#x0D; CONCLUSION: Although the increased load of HCV in our setup is an alarming situation the prevalence of type 3 genotype is a blessing in disguise. The success of sustained viral response after various combinations of direct antiviral therapy and interferon-free treatment is hope for the ultimate cure of the disease and avoidance of debilitating side eﬀects related to interferon.

Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences