jimnoneill/paper-to-field-training huggingface dataset:
Preoperative Sizing of Grafts for Transfemoral Endovascular Aneurysm Management: A Prospective Comparative Study of Spiral CT Angiography, Arteriography, and Conventional CT Imaging

Purpose: To define the impact of spiral computed tomographic angiography (CTA) with image reconstruction on graft selection for Transfemoral Endovascular Aneurysm Management (TEAM) by comparing it to conventional computed tomography (CT) and contrast arteriography. Methods: Twenty-one candidates for TEAM were included. The diameters of the superior and inferior aneurysm necks and lengths between the graft attachment sites were measured using the three imaging techniques. These measurements and their consequences on graft selection were studied. Results: The difference in length sizing between spiral CTA and arteriography never exceeded 1 cm; however, lengths measured by conventional CT scanning resulted in underestimation of graft length in 91% of patients. Graft diameters were chosen too small in 62% of the patients when based on arteriographic diameter measurements. A graft of similar diameter was selected by spiral CTA and conventional CT scanning in 81% of the patients, while minor oversizing by conventional CT scanning was found in 14%. Conclusions: Neither conventional CT scanning nor arteriography is adequate as a sole preoperative radiological investigation for TEAM graft sizing. Spiral CTA with image processing produces all information required for selection of tho-optimal graft size and should be regarded the method of first choice for this purpose.

Topic: Aortic aneurysm repair treatments
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Unproductive Participation and Protection Against Germs: Technical-Ritualistic Practices in Heart Surgery

Abstract There is a debate in the social sciences about the character of the effectiveness of techniques and performances in the surgical field. The literature is divided into different postures, which highlight the ritualistic aspects of techniques and procedures (Katz, 1981; Rawlings, 1989; Hirschauer, 1991) or emphasize their pragmatic efficacy and the purely antiseptic character of sterilization procedures (Collins, 1994). During ethnographic research conducted in the field of cardiac technology production, I observed that these spheres are, in fact, intertwined. Additionally, I believe that it is necessary to consider that the formation of the surgical field (a procedure that will be explored in the following article), as well as the employment of other hygienic procedures are not simply rituals to keep microorganisms away, but are also part of the conditioning of the “surgeon's body”. Surgeries are risky procedures that require the development of techniques in order to avoid contamination with both microscopic agents and unproductive involvement. The threat of unwanted involvement implies the development of skills that allow for “good participation”. In my ethnographic research, in contrast to the surgeries performed on humans in the operating rooms, the procedures performed on animals show that the process of “depersonalization” (that is, the subject's erasure through the construction of the surgical field) in experimental surgery has the effect of naturalizing non-human animals, instituting them as substitutes for humans. This requires a delicate game of approximation and distancing on the part of the surgeon and the medical team. In general, my aim here is to describe and analyze the technical-ritualistic aspects that are part of cardiac interventions and which underlie the establishment of the surgical field, seeking to dilute the dichotomy established in the social sciences between a technical-functional pole and a ritual-symbolic one.

Topic: Geographies of human-animal interactions
Subfield: Geography, Planning and Development
Field: Social Sciences
Domain: Social Sciences
Optimal stabilization for long-term storage of nucleic acid-based CRISPR/Cas12a assay for SARS-CoV-2 detection

In this long-term storage study, we optimized the lyophilization conditions of each reaction stage of a nucleic acid-based assay for SARS-CoV-2 detection. The stability testing demonstrated that the dried reactions from all 3 steps (cDNA synthesis, isothermal amplification and detection) can be kept at -20°C or 4°C for up to 6 or 3 months, respectively, whereas, if stored at 25°C or 37°C, the reagents only could be stored for a few days without quality loss. This suggests that we can have the dried reactions at -20°C for long-term storage until needed. Moreover, this assay is now simpler to perform as each of the 3 steps now proceeds with pre-mixed regents lyophilized in a single tube for each step.

Topic: CRISPR and Genetic Engineering
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CCDC 662336: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
EFFECTS OF A FENUGREEK SEED EXTRACT ON FEEDING BEHAVIOUR IN THE RAT

1URA 599 du CNRS Faculté de Médecine, 34060 Montpellier 2Universite Montpellier II, 34095 Montpellier, France 3Laboratoires Monal, 91127 Palaiseau, France

Topic: Child Nutrition and Feeding Issues
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Online-Group Intervention after Suicide Bereavement through the Use of Webinars: Study Protocol for a randomized controlled Trial

<title>Abstract</title> Introduction The death of a significant person through suicide is a very difficult experience and can have long-term impact on an individual’s psychosocial and physical functioning. However, there are only few studies which have examined the effects of interventions in suicide survivors. In the present study, we examined an online-group intervention for people bereaved by suicide using a group-webinar. Methods The intervention was developed based on focus groups with the target group. The cognitive-behavioral 12-module webinar-based group intervention focuses on suicide bereavement related themes such as feelings of guilt, stigmatization, meaning reconstruction and the relationship to the deceased. Further, the webinar includes testimonial videos and psychoeducation. The suicide survivors are randomized to the intervention or the waiting- list in a group cluster randomized controlled trial. Primary outcome were suicidality (BSSI) and depression (BDI-II), secondary outcomes are symptoms of prolonged grief disorder (ICG-D), PTSD (IES-R), stigmatization (STOSASS) and posttraumatic cognitions (PTCI). Discussion Previous studies of internet-based interventions for the bereaved were writing interventions showing large treatment effects. Little is known about the use of webinars as group interventions. Advantages and challenges of this novel approach of psychological interventions will be discussed.

Topic: Grief, Bereavement, and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Oxidative stress and release of bioactive lipid peroxidation by‐products following herpes simplex virus infection of neural cell cultures

Herpes simplex virus type 1 (HSV‐1) encephalitis is associated with oxidative tissue damage. The relative contributions of direct viral toxic effects and that of reactive inflammation to this damage are unknown. To determine whether HSV‐1 infection causes oxidative stress and lipid peroxidation in neural cells, mouse P19N neural cell cultures were infected with HSV‐1 and cellular levels of reactive oxygen species (ROS) and the release of lipid peroxidation by‐products malondialdehyde (MDA) and hydroxyalkenals [4‐HAE (predominantly 4‐hydroxy‐2‐nonenal, HNE)] into the tissue culture medium were then measured. HSV‐1 infection increased ROS levels in neural cells as early as one hour post infection (p.i.) and ROS levels remained elevated at 24 hours p.i. HSV‐1 infection also was associated with increased levels of MDA/HAE in the culture medium at 2 and 4 hours p.i. HSV‐1 replication in P19N cells was inhibited by the antioxidant compound ebselen and high concentrations of HNE, but was increased by low concentrations of HNE. These findings suggest that viral effects may directly contribute to oxidative tissue damage caused by HSV‐1 encephalitis. Furthermore, these data suggest that HSV‐1 infection‐induced soluble, bioactive lipid peroxidation by‐products may be mediators of HSV‐1‐induced tissue damage of infected and bystander cells as well as regulators of HSV‐1 replication in the nervous system.

Topic: Herpesvirus Infections and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
DEVS/SOA: A Cross-Platform Framework for Net-centric Modeling and Simulation in DEVS Unified Process

Discrete Event Specification (DEVS) environments are implemented over middleware systems such as HLA, RMI, CORBA and others. DEVS exhibits concepts of systems theory and modeling and supports capturing the system behavior from the physical and behavioral perspectives. Further, they are implemented using object-oriented languages like Java and C++. This research work uses the Java platform to implement DEVS over a Service Oriented Architecture (SOA) framework. Called the DEVS/SOA, the framework supports a development and testing environment known as DEVS Unified Process that is built on a model continuity-based lifecycle methodology. DEVS Unified Process allows DEVS-based Modeling and Simulation (M&amp;S) over net-centric platforms using DEVS/SOA. This framework also provides the crucial feature of run-time composability of coupled systems using SOA. We describe the architecture and designs of the server and the client. The client application communicates with multiple servers hosting DEVS simulation services. These simulation services are developed using the proposed symmetrical services architecture wherein the server can act as both a service provider and a service consumer contrary to the unidirectional client—server paradigm. We also discuss how this services-based architecture provides solutions for cross-platform distributed M&amp;S. We demonstrate the DEVS/SOA framework with a scenario of Joint Close Air Support specified in Business Process Modeling Notation (BPMN). We also provide a real-world application of network health monitoring using DEVS/SOA-layered architectural framework.

Topic: Simulation Techniques and Applications
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Suppliers selection based on intuitionistic fuzzy dimensional analysis

Supplier selection is a crucial activity in the supply chain management, and fundamentally it is a multi-criteria decision-making problem. However, the interaction of the criteria, the uncertain regarding to subjectivity and the imprecise information generally present in the provider selection process is still an open issue. The main purpose of this paper is to arise a new method to support the provider selection process. In this sense, this paper introduces the intuitionistic fuzzy version of dimensional analysis under a group decision making and multi-criteria environment applied to suppliers selection. Likewise, a set of decision makers reveal their preferences about the criteria and options in evaluation by mean of a linguistic grade that are mapped via intuitionistic numbers. Consequently, the importance of each decision maker and criteria is considered in the method. Hence, the methodology assumes that exist a choice better than the rest which is called ideal alternative. Each choice in evaluation, is compared with that ideal to induce an index of similarity. Additionally, the alternative with highest index of similarity is proposed as solution to the supplier selection problem. The method offer a systematic mode to deal with the interrelationship between the criteria attached into the decision making sphere. Finally, a numerical example is addressed to supplier selection to facilitate the understanding of the proposed method.

Topic: Multi-Criteria Decision Making
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Alternative Method of Allelic Discrimination

5' nuclease assays for allelic discrimination use both a wild-type and a mutant probe. Here we present a new method for genotyping by 5' nuclease assays that dispenses with the mutant probe, using the wild-type probe together with a probe for a reference gene known to be present in two copies to determine the copy number of the wild type allele relative to the reference gene. The copy number of the wild-type allele then determines the genotype: two copies indicates homozygous wild-type; one copy indicates heterozygous; and zero copies indicates homozygous mutant. We were able to use our method to correctly genotype three alleles of the thiopurine methyl transferase (TPMT) gene: TPMT *2 (c.G238C), *3B (c.G460A) and *3C (c.A719G). Our approach can be used as an alternate allelic discrimination strategy that is cost effective when multiple TaqMan assays are performed on a sample.

Topic: CRISPR and Genetic Engineering
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
WE-D-211A-07: Medical Response to Radiation Incidents, summary of ACMP/AAPM Workshop

The American College of Medical Physics and the AAPM recently co-sponsored an all day workshop on Response to Radiation Incidents. The talks included information on the federal response framework as well as how medical physicists could become involved through organizations such as the Medical Reserve Corps (MRC). Within the Florida MRC, a section known as the Radiation Response Volunteer Corps (RRVC) was formed. The Florida AAPM and FL Health Physics Society chapters participated in training in June 2008. The RRVC was designed specifically for medical and health physicists. Information on the MRC and RRVC were presented at the workshop. In the afternoon, staff from the Radiation Emergency Assistance Center and Training Site (REAC/TS) conducted a realistic demonstration of patient decontamination procedures. All participants received a toolkit with valuable training tools.

Topic: Advances in Oncology and Radiotherapy
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Evaluation of Antiangiogenic Effect of the Leaves of Justicia gendarussa (Burm. f ) (Acanthaceae) by Chrio Allontoic Membrane Method

Problem statement: Angiogenesis involves the formation of new blood vessels from pre-existing blood vessels plays a crucial role in pathological processes such as diabetic retinopathy, arthritis and in the growth of solid tumors. Numerous reports had pointed out to the crucial role of neovascularization in the malignancy of tumors and other angiogenesis dependant diseases. Antiangiogenic therapy which targets activated endothelial cells having several advantages over therapy directed against tumor cells. Determine the antiangiogenic potential of the leaves of Justicia gendarussa by CAM (Chrio Allontoic Membrane assay) method. Approach: A chick chrio allontoic membrane assay was carried out. Six eggs were used per experiment to test one extract at a given dose. The upper part of the shell of the eggs were removed like a window, covered with a plastic film and incubated for 72 h. When the CAM is about 1.8-2.6 cm development the pellets containing test solution both aqueous and ethanolic placed on the CAM by means of micropipette. After 24 h antiangiogenic effect was measured by means of a stereomicroscope to observe the avascular zone surrounding the pellet. Results: Below 10 μg both extracts showed no effect. In the dose range of 50 μg mL-1 of ethanolic extract and 100 μg mL-1 of aqueous extract showed inhibition of neovascularization. The effect was in dose dependant manner. Conclusion: These results indicated that both aqueous and ethanolic extracts of the leaves of Justica gendarussa inhibits the angiogenesois in dose dependant fashion and it provides a scientific basis for its traditional use in the treatment of arthtitis which is an angiogenesis dependant disease.

Topic: Plant-derived Lignans Synthesis and Bioactivity
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
5-(4-Aminobutylaminomethyl)uracil, an unusual pyrimidine from the dioxyribonucleic acid of bacteriophage .phi.W-14

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5-(4-Aminobutylaminomethyl)uracil, an unusual pyrimidine from the dioxyribonucleic acid of bacteriophage .phi.W-14A. M. B. Kropinski, R. J. Bose, and R. A. J. WarrenCite this: Biochemistry 1973, 12, 1, 151–157Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/bi00725a025https://doi.org/10.1021/bi00725a025research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Topic: Metal complexes synthesis and properties
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
On Segre products, $F$-regularity, and finite Frobenius representation type

We study the behavior of various properties of commutative Noetherian rings under Segre products, with a special focus on properties in positive prime characteristic defined using the Frobenius endomorphism. Specifically, we construct normal graded rings of finite Frobenius representation type that are not Cohen-Macaulay.

Topic: Commutative Algebra and Its Applications
Subfield: Algebra and Number Theory
Field: Mathematics
Domain: Physical Sciences
Ancient Chinese Wars

While China's ancient warriors often countered Shih-strategy with Li-strategy, two major wars provide especially clear comparisons. In the Warring States period, Xiang Yu (?–203 BC) of Chu emerged as the prototypical Li-strategist facing Liu Bang (?–195 BC) of Han. In the Three Kingdoms period, Liu Bei (AD 161–223?) of Shu Han used Shih-strategy against Cao Cao (AD 155–230?) of Wei.KeywordsMilitary ForceShandong PeninsulaMilitary PowerWarring States PeriodSubordinate StateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Topic: Chinese history and philosophy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Renal mechanisms of antihypertensive effects caused by inhibition of soluble epoxide hydrolase in Cyp1a1‐Ren‐2 transgenic rats.

We examined the hypothesis that antihypertensive responses to inhibition of soluble epoxide hydrolase (sEH) are mediated by natriuretic effects of increased epoxyeicosanoids in transgenic rats with inducible expression of the mouse renin gene [strain name Cyp1a1‐Ren‐2]. Hypertension was induced in Cyp1a1‐Ren‐2 rats through dietary administration of indole‐3‐carbinol (I3C; 0.3%) for 11 days. The sEH inhibitor, cis ‐4‐[4‐(3‐Adamantan‐1‐yl‐ureido)‐cyclohexyloxy]‐benzoic acid ( c ‐AUCB, 13 mg/L) was given in drinking water. Blood pressure (BP) was monitored by radiotelemetry in conscious animals (n=6‐8). Sodium excretion and proteinuria were determined in 24 hour urine samples. c ‐AUCB had no effects in non‐induced normotensive group. However, at the end of experimental period, c‐AUCB treatment attenuated the development of hypertension induced by I3C (systolic BP 181 ± 4 vs. 202 ± 5 mmHg, p&lt;0.05), the loss in body weight (254 ± 4 vs. 228 ± 3 g, p&lt;0.05) and proteinuria (27 ± 2 vs. 34 ± 3 mg/day, p&lt;0.05) when compared with untreated rats. Moreover, c ‐AUCB induced natriuretic responses in treated rats (0.79 ± 0.06 vs. 0.57 ± 0.07 mmol/day, p&lt;0.05) compared to untreated group. These data suggest that antihypertensive responses to inhibition of soluble epoxide hydrolase in these transgenic rats are mediated by the natriuretic and renoprotective effects in the kidney.

Topic: Eicosanoids and Hypertension Pharmacology
Subfield: Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Data from X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis

&lt;div&gt;Abstract&lt;p&gt;Biological sex profoundly conditions organismal development and physiology, imposing wide-ranging effects on cell signaling, metabolism, and immune response. These effects arise from sex-specified differences in hormonal exposure, and from intrinsic genetic and epigenetic differences associated with the presence of an XX versus XY chromosomal complement. In addition, biological sex is now recognized to be a determinant of the incidence, presentation, and therapeutic response of multiple forms of cancer, including cancers not specifically associated with male or female anatomy. Although multiple factors contribute to sex-based differences in cancer, a growing body of research emphasizes a role for differential activity of X- and Y-linked tumor-suppressor genes in males and females. Among these, the X-linked &lt;i&gt;KDM6A/UTX&lt;/i&gt; and &lt;i&gt;KDM5C/JARID1C/SMCX&lt;/i&gt;, and their Y-linked paralogs &lt;i&gt;UTY&lt;/i&gt;/&lt;i&gt;KDM6C&lt;/i&gt; and &lt;i&gt;KDM5D/JARID1D/SMCY&lt;/i&gt; encode lysine demethylases. These epigenetic modulators profoundly influence gene expression, based on enzymatic activity in demethylating H3K27me3 and H3K4me3, and nonenzymatic scaffolding roles for large complexes that open and close chromatin for transcription. In a growing number of cases, mutations affecting these proteins have been recognized to strongly influence cancer risk, prognosis, and response to specific therapies. However, sex-specific patterns of mutation, expression, and activity of these genes, coupled with tissue-specific requirement for their function as tumor suppressors, together exemplify the complex relationship between sex and cancer vulnerabilities. In this review, we summarize and discuss the current state of the literature on the roles of these proteins in contributing to sex bias in cancer, and the status of clinical agents relevant to their function.&lt;/p&gt;&lt;/div&gt;

Topic: Protein Degradation and Inhibitors
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences