<i>Cryptococcus neoformans</i> Pericarditis Associated with Hodgkin's Disease

Case Studies1 April 1966Cryptococcus neoformans Pericarditis Associated with Hodgkin's DiseaseCHARLES P. DUVALL, M.D., PAUL P. CARBONE, M.D.CHARLES P. DUVALL, M.D.Search for more papers by this author, PAUL P. CARBONE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-850 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCryptococcal infections usually involve the meninges and lungs, but spread to other distant sites can occur. Cardiac involvement is noted rarely but, to our knowledge, pericarditis with effusion has not been reported previously (1, 2). The following case represents an example of acute Cryptococcus neoformans pericarditis with effusion in a patient with Hodgkin's disease in remission.CASE REPORTA 21-year-old college student with biopsy-confirmed Hodgkin's disease was admitted to the Clinical Center of the National Institutes of Health on September 10, 1964, complaining of cough and chest pain of 2 weeks' duration.One year previously (October, 1963) he had noted...References1. LITTMAN ML: Cryptococcosis (torulosis), current concepts and therapy. Amer. J. Med. 27: 976, 1959. CrossrefMedlineGoogle Scholar2. LITTMANZIMMERMAN MLLE: Cryptococcosis, Torulosis or European Blastomycosis. 205 pages. Grune & Stratton, New York, 1956. Google Scholar3. CORNELLSHOOKHOFF AHB: Actinomycosis of the heart simulating rheumatic fever. Arch. Intern. Med. (Chicago) 74: 11, 1944. CrossrefGoogle Scholar4. SPODICK DH: Acute Pericarditis. Grune & Stratton, New York, 1959, pp. 16, 92, 117-118. Google Scholar5. BILLINGSCOUCH FTOA: Pericardial calcification and histoplasmin sensitivity. Ann. Intern. Med. 42: 654, 1955. LinkGoogle Scholar6. KLIEGERFISHER HLER: Fibrocalcific constrictive pericarditis due to Histoplasma capsulatum. New Eng. J. Med. 267: 593, 1962. CrossrefMedlineGoogle Scholar7. MCNERNEY JJ: Histoplasmin sensitivity associated with pericardial calcification. Amer. Heart J. 52: 609, 1956. CrossrefMedlineGoogle Scholar8. WOOLEYHOSIER CFDM: Constrictive pericarditis due to Histoplasma capsulatum. New Eng. J. Med. 264: 1230, 1961. CrossrefMedlineGoogle Scholar9. DIXGURKAYNAK JHN: Histoplasmosis with massive pericardial effusion and systemic involvement. Report of a case. JAMA 182: 687, 1962. CrossrefMedlineGoogle Scholar10. GREGORIADESLANGELUTTIGPOLK DGHVJW: Pericarditis with massive effusion due to histoplasmosis. A case report. JAMA 178: 331, 1961. CrossrefMedlineGoogle Scholar11. LEEDOMPRITCHARDKEER JMJCLM: Probable histoplasma pericarditis with effusion: report of a case with recurrence. Arch. Intern. Med. (Chicago) 112: 652, 1963. CrossrefMedlineGoogle Scholar12. OWENSCHERRSEGRE GESNEJ: Histoplasmosis involving the heart and great vessels. Amer. J. Med. 32: 552, 1962. CrossrefGoogle Scholar13. BAKERBRIAN RDEW: Blastomycosis of the heart. Amer. J. Path. 13: 139, 1937. MedlineGoogle Scholar14. FRAUMENIFEAR JFRE: Purulent pericarditis in aspergillosis. Ann. Intern. Med. 57: 823, 1962. LinkGoogle Scholar15. CHAPMANKAPLAN MGL: Cardiac involvement in coccidioidomycosis. Amer. J. Med. 23: 87, 1957. CrossrefMedlineGoogle Scholar16. LOMBARDORABSONDODGE TAASHT: Mycotic endocarditis—report of a case due to Cryptococcus neoformans. Amer. J. Med. 22: 664, 1957. CrossrefMedlineGoogle Scholar17. LONGMIREGOODWIN WPTC: Generalized torula infection. Case report and review with observations on pathogenesis. Bull. Hopkins Hosp. 64: 22, 1939. Google Scholar18. BURGERMORTON RECB: Torula infection—a review and report of 4 cases. Surgery 15: 312, 1944. Google Scholar19. HAUGENBAKER RKRD: The pulmonary lesions in cryptococcosis with special reference to subpleural nodules. Amer. J. Clin. Path. 24: 1381, 1954. CrossrefMedlineGoogle Scholar20. GENDELENDENORMAN BRMSL: Cryptococcosis—a review with special reference to apparent association with Hodgkin's disease. Amer. J. Med. 9: 343, 1950. CrossrefMedlineGoogle Scholar21. SABESINFALLONANDRIOLE SMHJVT: Hepatic failure as a manifestation of cryptococcosis. Arch. Intern. Med. (Chicago) 111: 661, 1963. CrossrefMedlineGoogle Scholar22. WEBSTER BH: Bronchopulmonary cryptococcosis. Dis. Chest. 43: 513, 1963. CrossrefMedlineGoogle Scholar23. TAKOS MJ: Experimental cryptococcosis produced by the ingestion of virulent organisms. New Eng. J. Med. 254: 598, 1956. CrossrefMedlineGoogle Scholar24. EMMONS CW: Isolation of Cryptococcus neoformans from soil. J. Bact. 62: 685, 1951. CrossrefMedlineGoogle Scholar25. CARTERYOUNG HSJL: Note on the isolation of Cryptococcus neoformans from a sample of milk. J. Path. Bact. 62: 271, 1950. CrossrefMedlineGoogle Scholar26. ZIMMERMANRAPPAPORT LEH: Occurrence of cryptococcosis in patients with malignant disease of reticuloendothelial system. Amer. J. Clin. Path. 24: 1050, 1954. CrossrefMedlineGoogle Scholar27. MILLER DG: Patterns of immunological deficiency in lymphomas and leukemias. Ann. Intern. Med. 57: 703, 1962. LinkGoogle Scholar28. SCHIERROTHOSTROFFSCHRIFT WWAGMH: Hodgkin's disease and immunity. Amer. J. Med. 20: 94, 1956. CrossrefMedlineGoogle Scholar29. SOKALPRIMIKIRIOS JEN: The delayed skin test response in Hodgkin's disease and lymphosarcoma. Effect of disease activity. Cancer 14: 597, 1961. CrossrefGoogle Scholar30. AISENBERG AC: Studies on delayed hypersensitivity in Hodgkin's disease. J. Clin. Invest. 41: 1964, 1962. CrossrefMedlineGoogle Scholar31. AISENBERG AC: Hodgkin's disease—prognosis, treatment, and etiologic and immunologic considerations. New Eng. J. Med. 270: 508, 565, 617, 1964. CrossrefMedlineGoogle Scholar32. DUBIN IN: The poverty of the immunological mechanism in patients with Hodgkin's disease. Ann. Intern. Med. 27: 898, 1947. LinkGoogle Scholar33. LAMBPILNEYKELLYGOOD DFWDRA: A comparative study of the incidence of anergy in patients with carcinoma, leukemia, Hodgkin's disease and other lymphomas. J. Immun. 89: 555, 1962. MedlineGoogle Scholar34. DIXONTALMAGEMAURER FJDWPH: Radiosensitive and radioresistant phases in the antibody response. J. Immun. 68: 693, 1952. MedlineGoogle Scholar35. SCHWABMOLLHALLBREANKIRKHAWNJANEWAY LFCTHMCVCA: Experimental hypersensitivity in the rabbit. J. Exp. Med. 91: 505, 1950. CrossrefMedlineGoogle Scholar36. BROWN MH: Effect of ionizing radiation on immunity. Canad. Med. Ass. J. 87: 1184, 1962. Google Scholar37. TORACK RM: Fungus infections associated with antibiotic and steroid therapy. Amer. J. Med. 22: 872, 1957. CrossrefMedlineGoogle Scholar38. LEVINEZIMMERMANSCORZA SHMA: Experimental cryptococcosis (torulosis). Amer. J. Path. 33: 385, 1957. MedlineGoogle Scholar39. BAKER RD: Leukopenia and therapy in leukemia as factors predisposing to fatal mycoses. Amer. J. Clin. Path. 37: 358, 1962. CrossrefMedlineGoogle Scholar40. WEBBHERRING WRJL: Pericarditis due to histoplasmosis. Amer. Heart J. 64: 679, 1962. CrossrefMedlineGoogle Scholar41. SPICKARDBUTLERANDRIOLEUTZ AWTVJP: The improved prognosis of cryptococcal meningitis with amphotericin B therapy. Ann. Intern. Med. 58: 66, 1963. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Solid Tumor Service, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Paul P. Carbone, M.D., Head, Solid Tumor Service, Medicine Branch, NCI, Building 10 12-N-228, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCryptococcal pericarditis in a heart transplant recipientCryptococcusneoformans pericarditis in a lung transplant recipient: Case report, literature review and pearlsCryptococcus neoformans infections in patients with lymphoproliferative neoplasmsFulminant Cryptococcus neoformans infection with fatal pericardial tamponade in a patient with chronic myelomonocytic leukaemia who was treated with ruxolitinib : Case report and review of fungal pericarditisCryptococcus neoformans infective endocarditis of native valves in an immunocompetent hostPostradiation Pericarditis with Chronic Pericardial EffusionDAVID S. MASLAND, M.D., C. T. ROTZ JR., M.D., JOHN H. HARRIS JR., M.D.Deep-Seated Mycotic Infections, Allergy to Fungi and MycotoxinsPurulent Constrictive Pericarditis Caused by Nocardia asteroidesGEORGE P. SUSENS, M.D., ABDUL AL-SHAMMA, M.D., JOHN C. ROWE, M.D., CHARLES C. HERBERT, M.D., MILTON L. BASSIS, M.D., GRANVILLE C. COGGS, M.D. 1 April 1966Volume 64, Issue 4Page: 850-856KeywordsCryptococcus neoformansDyspneaFibrosisHodgkin lymphomaInfectious diseasesIschemiaLung and intrathoracic tumorsLungsLymphomaMeninges Issue Published: 1 April 1966 PDF downloadLoading ...

Topic: Fungal Infections and Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences