jimnoneill/paper-to-field-training huggingface dataset:
Long-term Results of ABI in Children With Severe Inner Ear Malformations

Objective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retrosigmoid approach with a pediatric neurosurgeon. Intraoperatively, electrical auditory brainstem response was utilized. Initial stimulation was done 4 to 5 weeks postoperatively. Outcomes were evaluated with Categories of Auditory Performance (CAP), speech intelligibility rate (SIR), functional auditory performance of cochlear implant (FAPCI) and Manchester Spoken Language Development Scale scores; receptive and expressive language ages were determined. Results: Sixty children who received ABI were between ages of 12 and 64 months. Thirty-five patients with follow up period of at least 1 year, were reported in means of long-term audiological and language results. The most prevelant inner ear malformation was cochlear hypoplasia (n = 19). No major complication was encountered. Majority of the patients were in CAP 5 category, which implies that they can understand common phrases without lip reading. SIR was found out to be better with improving hearing thresholds. Children with ABI were performing worse than average cochlear implantation (CI) users when FAPCI scores were compared. Patients with the best hearing thresholds have expressive vocabulary of 50 to 200 words when evaluated with Manchester Spoken Language Development Scale. There was no relationship between the number of active electrodes and hearing thresholds. The type of inner ear anomaly with the best and the worst hearing thresholds were common cavity and cochlear aperture aplasia, respectively. Patients with additional handicaps had worse outcomes. Among 35 children, 29 had closed set discrimination and 12 developed open set discrimination above 50%. It was determined that, progress of the patients is faster in the initial 2 years when compared with further use of ABI. Conclusion: ABI is an acceptable and effective treatment modality for pediatric population with severe inner ear malformations. Bilateral stimulation together with CI and contralateral ABI should be utilized in suitable cases.

Topic: Hearing Loss and Rehabilitation
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
X-linked Adrenoleukodystrophy in Three Filipino Families

We report five Filipino male children from three families with the childhood cerebral form of adrenoleukodystrophy. All patients demonstrated deterioration in mental and developmental skills with onset of symptoms ranging from 6 to 9 years of age. Diagnosis was confirmed by elevated very long chain fatty acid (VLCFA) levels and characteristic magnetic resonance imaging (MRI) findings. Carrier testing was carried out. Genetic counseling was performed on families, thereby aiding them to cope and accept the diagnosis.

Topic: Metabolism and Genetic Disorders
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
DFT calculations of light‐induced excited states and comparison with time‐resolved crystallographic results

Abstract DFT calculations of the ground and first excited states of several transition metal complexes have been performed to complement time‐resolved diffraction experiments. The results from different functionals and relativistic treatments are tested against both diffraction and spectroscopic values. Calculations of the d 8 –d 8 complex [Pt 2 (pyrophosphite) 4 ] 4− quantitatively reproduce metal–metal shortening on excitation to the triplet state and support bond formation between the two metal centers, as do calculations on [Rh 2 (1,3‐diisocyanopropane) 4 ] 2+ . Results on homoleptic and heteroleptic copper(I) 2,9‐dimethyl−1,10‐phenanthroline (dmp) complexes, which are investigated because of their potential for solar energy capture, confirm considerable molecular deformations on excitation. The distortion calculated for the isolated complex [Cu(dmp)(dmpe)] + (dmpe=1,2‐bis(dimethylphosphino)ethane) is significantly larger than observed in the crystal, indicating the constraining effect of the crystalline environment. The change in the net charge of the Cu atom upon photo‐induced metal‐to‐ligand charge transfer is less than 0.2 e, showing the limitations of the formal Cu(I)→Cu(II) designation. Electron density difference maps show a pronounced change in electronic structure of the Cu atom on excitation. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2005

Topic: Photochemistry and Electron Transfer Studies
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Household Land Allocations and the Youth Land Access Nexus: Evidence from the Techiman Area of Ghana

Building inclusive societies that reflect the needs of all categories of people within the social spectrum is critical to achieving sustainable development. This is reflected in the Sustainable Development Goals (SDGs) which among things seek to ‘by 2030, empower and promote the social, economic and political inclusion of all, irrespective of age, sex. This places enormous tasks on all governments especially in developing countries like Ghana to ensure that the youth are not left behind in access and control over land as a building block for economic empowerment. This task is particularly critical in view of the sheer numbers of the youth and yet economically marginalized underpinned by high levels of unemployment and underemployment. This case study investigates the youth land rights within the context of household landholdings and allocations dynamics. The study took place in the Techiman area in Ghana. The study sampled 455 youth and 138 household heads. The study revealed that household lands are important building block for majority of the youth in the Techiman area. It gives them a sense of security in the usage. However, the youth’s ability to depend on this source to kick start independence economic life is beset with land scarcity, non-allocation and accumulation by the lineage heads who have prerogative over household lands. The study underscores the need for social welfare scheme for the aged farmers so that they can timely release land to the younger ones without fearing for what to sustain them. There is also the need for government to create land banks to support the willing youth to engage in agriculture.

Topic: Land Rights and Reforms
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Effect of Seasonal Dynamics on Queen Densities of the Argentine Ant (Linepithema Humile) in an Invaded Natural Area of the NE Iberian Peninsula

The annual elimination of large numbers of Argentine ant queens near the advance front of an invasion could be a useful tool for weakening the species’ dispersion and, therefore, limiting its establishment in non-invaded areas. However, before carrying out trials to test the effectiveness of this method it would be essential to have sufficient knowledge of the effect of seasonal dynamics acting on the queens’ densities of the species in order to determine the most favourable period of the year to act. We analyzed the seasonal densities and nest dynamics of Argentine ant queens in an invaded Mediterranean natural ecosystem. We observed that the queens’ density varied depending on the season of the year and that this variation was mainly due to the seasonal dynamics of nest aggregations in winter and ant dispersions in summer. The greatest densities per litre of nest soil were observed in winter (December to March, approximately) and the lowest densities were observed in summer ( June to July). This information is essential for improving current knowledge of the Argentine ant’s biology and developing control methods based on the elimination of queens in invaded natural areas

Topic: Insect and Arachnid Ecology and Behavior
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Challenges of Supporting Effective Security and Justice Development Programming

Early 2010, the DAC International Network on Conflict and Fragility (INCAF) Task Team on
Peacebuilding, Statebuilding and Security commissioned an analysis of the critical impediments to
effective donor engagement in the area of security and justice development in conflict-affected and
fragile environments. This analysis seeks to inform a change agenda to help make donor support to
justice and security more effective. It is intended to serve as the base of a larger piece of work, and
builds on the World Bank‘s 2011 World Development Report and the OECD‘s 2011 Policy Guidance
on Supporting Statebuilding in Situations of Conflict and Fragility...

Topic: Global Peace and Security Dynamics
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Data from PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Analytically validated assays to interrogate biomarker status in clinical samples are crucial for personalized medicine. &lt;i&gt;PTEN&lt;/i&gt; is a tumor suppressor commonly inactivated in prostate cancer that has been mechanistically linked to disease aggressiveness. Though deletion of &lt;i&gt;PTEN&lt;/i&gt;, as detected by cumbersome FISH spot counting assays, is associated with poor prognosis, few studies have validated immunohistochemistry (IHC) assays to determine whether loss of PTEN protein is associated with unfavorable disease.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; PTEN IHC was validated by employing formalin fixed and paraffin-embedded isogenic human cell lines containing or lacking intact &lt;i&gt;PTEN&lt;/i&gt; alleles. PTEN IHC was 100% sensitive and 97.8% specific for detecting genomic alterations in 58 additional cell lines. PTEN protein loss was then assessed on 376 prostate tumor samples, and &lt;i&gt;PTEN&lt;/i&gt; FISH or high resolution single nucleotide polymorphism microarray analysis was done on a subset of these cases.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; PTEN protein loss, as assessed as a dichotomous IHC variable, was highly reproducible, correlated strongly with adverse pathologic features (e.g., Gleason score and pathologic stage), detected between 75% and 86% of cases with &lt;i&gt;PTEN&lt;/i&gt; genomic loss, and was found at times in the absence of apparent genomic loss. In a cohort of 217 high risk surgically treated patients, PTEN protein loss was associated with decreased time to metastasis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; These studies validate a simple method to interrogate PTEN status in clinical specimens and support the utility of this test in future multicenter studies, clinical trials, and ultimately perhaps for routine clinical care. &lt;i&gt;Clin Cancer Res; 17(20); 6563–73. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: PI3K/AKT/mTOR signaling in cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Nutritional Status of Mothers and Children in Pakistan as Compared to Other Neighbouring South Asian Countries

Malnutrition of women and children is one of the major problems in Pakistan. The prevalence of Protein Energy Malnutrition (PEM) in children under five year is 51%. It is one of the contributory factors of high infant and child under 5, morbidity and mortality in the country. This problem needs to be addressed properly in Pakistan for which the study should be undertaken urgently. According to state of world children 2000 UNICEF report, Pakistan position has been revealed worst in child under 5, mortality and infant mortality rate as compared to other neighbouring South Asian countries. The mortality rate was 136/1000 live births, in under five children in Pakistan. Similarly the mortality rate was 12 and 87/1000 in Sri Lanka and Maldives respectively during the same period. Infant mortality under one year was also on high side, it was 95 as compared to 38 in China during 1998. As compared to other south Asian countries the position in demographic and socio-economic indicators is hardly satisfactory, inspite of the fact that Pakistan is fully equipped with natural resources. There is need for sincere efforts for the development of socio-economic indicators.

Topic: Child Nutrition and Water Access
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
CCDC 755041: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Screening of Aggregatum Onion Varieties for Sodicity Tolerance

Sodicity is a major factor affects crop growth and productivity at global level. In the cultivablel and at global level, 23% is affected by salinity and 37% land by sodicity. Two seed propagating aggregatum onion varieties (CO 5, CO 6) and two bulb propagating aggregatum onion varieties (Permbalurlocal, thuraiyurlocal) were screened by employing germination test in an osmatic solution of NaHCO3 (Sodium bicorbanate). Three Replications of 20 seeds of each variety were counted and distributed over two layers of paper towel (21x21 cm) previously moistened with water equivalent to three times the dry weight of the paper and tied both ends with rubber band and kept in a plastic tray with different concentrations (0, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM) of NaHCO3 (sodium bicorbanate). Also another bulb propagated varieties, perambalur and thuraiyur local varieties bulb directly sown in beaker have 1.5 kg sand. Control beaker irrigated with only water and other beakers irrigated with different concentrations (25 mM, 50 mM, 75 mM and 100 mM) of sodium bicarbonate solution. Germination percentage was recorded 7 days after. At the end of the 21th day,in four aggregatumonion varieties where final germination per cent, root length, shootlength, vigourindex, stresstolerant index, relative water content and membrane stability index, were recorded in NaHCO3 solution as against the distilled water was calculated. The experiment was designed as a completely randomized design with two factors. As a result a decline in all onion growth paramers, with increasing sodicity stress has been recorded. Significant differences were observed betweenthe varieties and different NaHCO3 concentrations. Irrespective of NaHCO3 concentrations two seed propagating aggregatum onion varieties, CO 6 recorded significantly maximum stress tolerant indexcompare with CO 5 and two bulb propagating aggregatum onion varieties, Thuraiyur local variety recorded significantly maximum stress tolerant index compare with Perambalur local in all sodicity concentation. Based on stress tolerant index, CO 6 and thuraiyur local variety tolerant to sodicity stress and CO5, perambalurlocal variety susceptible to sodicity stress.

Topic: Garlic and Onion Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Investment Portfolio Management System

Abstract: The idea of this project is to automate the process of investing or trading based on users choice , by providing references to financial markets trajectory. This project helps a retail investor to meet his financial goals by automating the process and thereby remains manageable for them. The current projects usually reside on the principle of predicting the trend of the market or particular financial instrument .This can be done by using LSTM or prophet seasonality prediction model to predict non-linear trend in the market. Designing a bot to invest in instruments based on the users requirements will further help in automating the entire process. This ideated system is thought by integrating the smart predicting feature of the machine.

Topic: Stock Market Forecasting Methods
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Strengthening the Circle: Seeking Healthcare Equity for American Indians Experiencing Homelessness

Equitable healthcare is a concept that calls for more than just providing equal access to primary care services. In order to achieve equity for a particular community, the healthcare system must address the social factors that prevent better health for members of that community. Many studies have shown that the U.S. healthcare system does not provide equitable care either to American Indians or to people who are homeless. These studies have identified poverty, trauma, and low educational attainment as obstacles to improving health within both of these populations. However, there are no published studies that specifically explore healthcare equity for American Indians who are experiencing homelessness. My research attempts to fill this gap. In 2013, American Indians made up 4.3 percent of the total Missoula County population but 13.5 percent of Missoula's homeless. In an effort to determine how the healthcare system provides equitable care to American Indians who are homeless, I am conducting both informal and formal interviews with local American Indians living in the Poverello Center, an emergency housing shelter, or who are otherwise without stable housing. I am also collecting demographic data from public sources including the U.S. Census Bureau, the Montana Department of Public Health &amp; Human Services, and the Indian Health Service (IHS), as well as obtaining utilization data from the Poverello Center and Missoula Indian Center (MIC), the local IHS-funded healthcare organization. I will use the data I collect to gauge whether or not the healthcare system is currently meeting the needs of American Indians in Missoula who are homeless. I will also work with the Poverello Center and MIC to develop strategies for making the local healthcare system more equitable, such as incorporating traditional healers, expanding workforce development opportunities, and adding programs or reshaping current program designs to address trauma and co-occurring disorders.

Topic: Homelessness and Social Issues
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
Analysis and design student entrepreneurship information system

Abstract Entrepreneurship Course is a compulsory subject that must be accepted by all students of University of Pembangunan Nasional “Veteran” Jawa Timur. This is done with the goal that students have the spirit of entrepreneurship. For this reason, in order for entrepreneurship to continue until students graduate, a Student Entrepreneurship Information System is created or it is called Sistem Informasi Kewirausahaan Mahasiswa (Sirama) in Indonesia. In the following article we will discuss about the proposed system design as a place for entrepreneurship for students and alumni. The analysis design that will be discussed is System Flow, Data Flow Diagrams (DFD), and Conceptual Data Model (CDM) and Physical Data Model (PDM) which are generated from CDM. The conclusion of this article is the system design for developing programs using web applications.

Topic: Experimental Learning in Engineering
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead structural analysis of binding mode to mature and zymogen like enzymes

Cathepsin K CatK is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is unknown. We investigated two model cyanohydrazide inhibitors with differently positioned warheads an azadipeptide nitrile Gü1303 and a 3 cyano 3 aza amp; 946; amino acid Gü2602. Crystal structures of their covalent complexes were determined with mature CatK as well as a zymogen like activation intermediate of CatK. Binding mode analysis, together with quantum chemical calculations, revealed that the extraordinary picomolar potency of Gü2602 is entropically favoured by its conformational flexibility at the nonprimed primed subsites boundary. Furthermore, we demonstrated by live cell imaging that cyanohydrazides effectively target mature CatK in osteosarcoma cells. Cyanohydrazides also suppressed the maturation of CatK by inhibiting the autoactivation of the CatK zymogen. Our results provide structural insights for the rational design of cyanohydrazide inhibitors of CatK as potential drugs

Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
PRODUCTION VALUES OF INVESTIGATED SUGAR BEET HYBRIDS

Production values of 43 experimental and recognized sugar beet hybrids were conducted on the Zagreb location in the period 2003-2005. The trials included hybrids from six breeding institutions that sell sugar beet seed in the Republic of Croatia. Research results have revealed significant differences in yields and root quality among inve- stigated sugar beet hybrids. However, the results of a large number of hybrids were equal in value; namely, the dif- ference between them was within the statistically allowable deviation. The hybrids KW 0148 HR and Buda in 2003, Sofarizo and Takt were distinguished by high sugar yields in 2004, whereas Merak, Impact and Europa in 2005. The highest root yields were recorded for hybrids Dioneta, Buda and KW 0148 HR in 2003, Sofarizo, Takt, HI 0191 and Dorotea in 2004, Impact and SES 2371 in 2005. The highest root sugar contents were determined in hybrids Zita and Evelina in 2003, Cyntia, Diamant and Belinda in 2004, and Merak, Belinda and Cyntia in 2005.

Topic: Global Trade and Competitiveness
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Analysis of spontaneous, carcinogen‐induced and promoter‐induced chromosomal instability in patients with hereditary retinoblastoma

Abstract Skin fibroblasts from patients with hereditary retino‐blastoma (RB cells) were examined since predisposition to the tumour might be expected to involve some degree of chromosomal instability, as has been noted for several cancer‐prone conditions. Spontaneous and N ‐Methyl‐ N ′‐nitro‐ N ‐nitrosoguanidine (MNNG)‐induced aberration frequencies were measured, the cytogenetic effects of long‐term treatment with 12‐ O ‐tetradecanoyl‐phorbol‐13acetate (TPA) were examined and also the spontaneous and TPA‐induced sister chromatid exchange (SCE) frequencies. In all the studies the RB cells behaved in a similar fashion to normal human skin fibroblasts.

Topic: Ocular Oncology and Treatments
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences