jimnoneill/paper-to-field-training huggingface dataset:
Strategic development of enterprises in the new normal: digital transformations and innovative approaches to adaptation to changes and entropy resilience

The article is devoted to the analysis of the strategic development of enterprises in the conditions of the new normality, which was formed under the influence of the COVID-19 pandemic, the war in Ukraine and global economic crises. The authors highlight the key aspects of enterprises’ adaptation to changes, in particular, digitalization, innovation, sustainable development and risk resistance. It is substantiated that in the modern world, characterized by ontological uncertainty, enterprises are forced to operate in the conditions of the new normality, which is dictated by global challenges, in particular: pandemic, economic crises, environmental threats, military actions and galloping digitalization. It is determined that the key problem is that traditional strategic approaches no longer provide an adequate response to the dynamics of being, which is transforming at breakneck speed. The importance of a flexible strategic approach that ensures the long-term competitiveness of enterprises in a dynamic environment is considered. The emphasis is on digital transformation as a basis for increasing the efficiency of business processes, using environmentally sound solutions for sustainable development and integration into global supply chains. The authors investigate the impact of government support, employee mental well-being and innovative approaches on the resilience of enterprises during the crisis. Macroeconomic indicators are analyzed, in particular, labor market recovery, fiscal stability and foreign trade, which form the basis for strategic development. The issues of enterprise adaptation to long-term crisis conditions, the balance between environmental responsibility and economic benefit, as well as effective integration into international markets are discussed. The article emphasizes the need for a systemic approach to change management, which involves the use of innovations, digital technologies and sustainable development strategies to maintain competitiveness in an ever-changing world.

Topic: Economic Issues in Ukraine
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Effects of sugar concentration, natural ventilation and supporting materials on the growth of in vitro strawberry plantlets (Fragaria ananassa Duch.) and on the survival rate of ex vitro plantlets

The growth of strawberry (Fragaria ananassa Duch.) plantlets cultured in vitro as affected by sugar, types of supporting material and number of air exchange of the vessel was investigated. Shoots of in vitro strawberry plantlets were cultured on the on full strength MS (Murashige &amp; Skoog 1962) basal liquid medium with 30 g/l sugar and without sugar. Two types of supporting material, agar and florialite, and two levels of air exchange expressed by number of air exchange per vessel, 0.3 and 2.3 per hour, were studied. At the end of a 35-day culture period, fresh weight, dry weight, leaf area, number of leaves, chlorophyll content, photosynthetic net rate of plantlets grown on florialite soaked in sugar-free medium and under the higher number of air exchanges were greater than those in sugar-containing medium. The survival rate of ex vitro plantlets cultured under a high number of air exchange and supporting with florialite was also the highest (98%) among SA, SF, FA and FF treatments.

Topic: Plant tissue culture and regeneration
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Zinc supplementation normalizes gene expression and enhances neurogenesis in a rat model of traumatic brain injury

New interventions are needed to improve resilience to traumatic brain injury (TBI). To examine the role of zinc, rats were fed a zinc adequate (30 ppm) or supplemented (180 ppm) diet for 4 wks followed by a frontal cortex TBI using controlled cortical impact. Chronic zinc supplementation significantly improved spatial learning and memory, and reduced anxiety and depression‐like behaviors. Mechanistically, we hypothesized that zinc supplementation would prevent injury‐induced changes in gene expression and enhance hippocampal stem cell proliferation and survival. Hippocampal RNA was extracted 48 h after TBI to analyze mRNA abundance via the NimbleGen platform microarray. TBI altered the expression of over 170 mRNAs, approximately 70 of which were normalized in rats supplemented with zinc (p&lt;0.01). We identified genes involved in cell proliferation, apoptosis, survival, repair, and differentiation. Rats were also injected with the thymidine analogue EdU to label proliferating cells in the hippocampus. TBI doubled the number of proliferating cells in the dentate gyrus granular cell layer 24 h post‐injury (p&lt;0.05), and supplemental zinc increased this number by an additional 2 fold (p&lt;0.05). Ongoing work is characterizing the long‐term fate of these cells. These data show that zinc can be a novel and effective strategy for preventing adverse cellular, molecular, and behavioral outcomes associated with TBI. Grant Funding Source : Department of Defense/US Army MRMC

Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Structure-based assessment of cancerous mitochondria using deep networks

Mitochondrial functions are essential for cell survival. Pathologic situations, e.g. cancer, can impair mitochondrial function which is frequently reflected by an altered morphology. So far, feature description of mitochondrial structure in cancer remains largely qualitative. In this study, we propose a learning-based approach to quantitatively assess the structure of mitochondria isolated from liver tumor cell lines using convolutional neural network (CNN). Besides achieving a high classification accuracy on isolated mitochondria from healthy tissue and different tumor cell lines which the CNN model was trained on, CNN is also able to classify unseen tumor cell lines, which suggests its superior capability to capture the intrinsic structural transition from healthy to tumor mitochondria.

Topic: Machine Learning in Bioinformatics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
LHD nb2pwr_PortThrough #170717.1 (analyzed)

Neutral beam injector (NBI) power-PortThrough of beam line 2 (BL2). The effective power that actually reaches the plasma after the negative ion-based neutral particle beam emitted from the NBI system passes through BL2.

Topic: Gout, Hyperuricemia, Uric Acid
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Susceptibility of the eggs of the field slug <i>Deroceras reticulatum</i> to contact with pesticides and substances of biological origin on artificial soil

Summary The toxicity of 14 substances, including a number of pesticides, to the eggs of the pest slug Deroceras reticulatum was determined in laboratory experiments. Eggs were kept in contact with a precisely defined artificial soil to which a range of concentrations of the test substances had been applied. Mortality of the eggs was assessed every 24 h and the median lethal doses (LD 50 ) were determined. The herbicides bromoxynil, ioxynil and pyridate + bromoxynil, the insecticides thiocyclam, diflubenzuron and azadirachtin, the molluscicides metaldehyde and methiocarb, and other compounds such as carvone, iron‐EDDHA, saponin, and an extract of Pongamia pinnata , killed the eggs after periods of exposure ranging from 2 to 14 days, depending on the compound and the dose. Only two compounds, the insecticides imidacloprid and teflubenzuron, failed to kill the eggs of D. reticulatum at any of the doses tested. Values of LD 50 below 0.01 mg a.i. cm −2 were obtained for the herbicides bromoxynil, ioxynil and pyridate + bromoxynil, and for the biological pesticide azadirachtin. The feasibility of slug egg control in different contexts is discussed.

Topic: Mollusks and Parasites Studies
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Limon Fidanlarında Zamklanma, Kök ve Kök Boğazı Çürüklüğüne Neden Olan Phytophthora citrophthora’nın Miselyal Gelişimi Üzerine Sıcaklık ve Besi Ortamlarının Etkisi

Infected plant materials with Phytophthora citrophthora were collected from the outer and inner bark of lemon seedlings showing gummosis, crown and root rot in citrus orchard in Hatay province. Phytophthora isolates were obtained from infected five different lemon seedlings and purified on modified PARPH and PDA with different concentrations of antibiotics in vitro conditions. On the basis of colony morphology, five isolates were identified as P. citrophthora. The effect of culture media and temperature on mycelial growth of P. citrophthora were investigated. Colony patterns of P. citrophthora were performed on PDA, CMA, OMA, CA and HSA media and identified their microscopic structures. The radial mycelial growth of isolates was not dependent on media. In general, five different colony patterns of P. citrophthora were observed on the culture media; light and dense rosette pattern, slightly stellate pattern, stellate striated pattern, slightly petaloid pattern and non-pattern colony. The rate of the mycelial growth increased as temperature increased up to 25 °C and then decreased rapidly as temperature increased. Isolate Pc3 was determined the slowest while Pc1 and Pc5 were the fastest-growing isolates on agar media. The best mycelial growth of P. citrophthora was obtained on HAS medium while the least mycelial growth was obtained on CMA medium. Optimum temperature and the rate of mycelial growth were determined as 24.6 °C and 9.7 mm d-1 respectively.

Topic: Plant Pathogens and Resistance
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[Post-stroke vascular dementia: risk factors and clinical neuro-imaging features].

To analyze the status of risk factors for post-stroke vascular dementia, 128 patients with post-stroke dementia, aged from 50-79 years, have been studied. A control group included 125 patients, aged 50-79 years, with moderate cognitive impairment after stroke. A coronary heart disease was a significant risk factor for the patients aged from 50-59; coronary heart disease, diabetes mellitus, overweight and hyperlipidemia were significant risk factors for the aged 60-69, diabetes mellitus, overweight and hyperlipidemia were significant risk factors for the aged 70-79. The stroke-related factors were cerebral infarction in left hemisphere, frontal and temporo-occipital infarction, thalamic, basal ganglion; cerebral white-matter lesions. The mathematical model of post-stroke dementia prediction was created for patients with post-stroke moderate cognitive impairment.

Topic: Neurological Disorders and Treatments
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Exploiting Hope

In the Chapter 4 the author argues that fairness-based accounts of exploitation form a poor basis for understanding the distinctive wrongness of exploiting hope. Structural fairness or justice-based accounts are also problematic in the medical context. Structural exploitation can describe some instances of injustices giving rise to the potential for exploitation but not the distinctive character of exploiting hope. Rather, exploitation understood as a failure of respect gives the best interpretation of what is distinctly wrong with exploiting hope. Specifically, individuals with weighty hopes who take risky leaps of hope partially entrust their welfare to others. This entrustment creates obligations for others who may exploit an individual’s hopes when they use this relationship as an opportunity for gain without duly discharging their responsibilities for the hopeful person’s welfare. This is true of both genuine hope and false hope, where the hope is based on misinformation, misunderstanding, and/or fraud.

Topic: Optimism, Hope, and Well-being
Subfield: Applied Psychology
Field: Psychology
Domain: Social Sciences
One-step Preparation of a VHH-based Immunoadsorbent for the Extracorporeal Removal of β2-microglobulin

Dialysis-related amyloidosis (DRA), which has been widely recognized to be associated with the accumulation of β2-microglobulin (β2-m) in blood, is one of the most common complications in patients receiving long-term dialysis treatment. The most significant side-effect of existing hemodialysis sorbents for the removal of β2-m from blood is the loss of vital proteins due to non-specific adsorptions. Although the traditional antibodies have the capability to specifically remove β2-m from blood, high cost limits their applications in clinics. Single domain antibodies derived from the Camelidae species serve as a superior choice in the preparation of immunoadsorbents due to their small size, high stability, amenability, simplicity of expression in microbes, and high affinity to recognize and interact with β2-m. In this study, we modified the anti-β2-m VHH by the formylglycine-generating enzyme (FGE), and then directly immobilized the aldehyde-modified VHH to the amino-activated beads. Notably, the fabrication is cost- and time-effective, since all the preparation steps were performed in the crude cell extract without rigorous purification. The accordingly prepared immunoadsorbent with VHHs as ligands exhibited the high capacity of β2-m (0.75 mg/mL). In conclusion, the VHH antibodies were successfully used as affinity ligands in the preparation of novel immunoadsorbents by the site-specific immobilization, and effectively adsorbed β2-m from blood, therefore opening a new avenue for efficient hemodialysis.

Topic: Pancreatic function and diabetes
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
IPTEKS EDUKASI DALAM PENGAMATAN MELAKUKAN TRANSAKSI PERDAGANGAN KOMODITI BERJANGKA PADA PERUSAHAAN PIALANG PT. VICTORY INTERNATIONAL FUTURES

PT. Victory International Futures was established in 2003 as a brokerage company in the world financial market that uses information technology to support its business. Centered in the city of Surabaya in the heart of the Indonesian business city. PT. Victory International Futures is one of the institutions recognized by the Indonesian government. We provide 100% focus on trading via the internet using the "Meta Trader 5" system PT. Victory International Futures is under the supervision of the Commodity Futures Trading (BAPPEBTI), Member of Indonesia Commodity &amp; Derivatives Exchanges (ICDX) / Indonesian Commodity and Derivative Exchange (BKDI) and PT. Identrust Security International (ISI). Time never stops in the era of global trade and so does PT. Victory International Futures serves thousands of customers directly and always provides quality and professional financial services.Keywords : brokerage company, gold, forex, trading system via the internet

Topic: SMEs Development and Digital Marketing
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
Central Clearing Valuation Adjustment

This paper develops an XVA (costs) analysis of centrally cleared trading, parallel to the one that has been developed in the last years for bilateral transactions. We introduce a dynamic framework that incorporates the sequence of cash-flows involved in the waterfall of resources of a clearing house. The total cost of the clearance framework for a clearing member, called CCVA for central clearing valuation adjustment, is decomposed into a CVA corresponding to the cost of its losses on the default fund in case of defaults of other member, an MVA corresponding to the cost of funding its margins and a KVA corresponding to the cost of the regulatory capital and also of the capital at risk that the member implicitly provides to the CCP through its default fund contribution. In the end the structure of the XVA equations for bilateral and cleared portfolios is similar, but the input data to these equations are not the same, reflecting different financial network structures. The resulting XVA numbers differ, but, interestingly enough, they become comparable after scaling by a suitable netting ratio.

Topic: Banking stability, regulation, efficiency
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
The Wife of the Career-Oriented Submariner in Mid-Life Transition.

The wife of a career-oriented, senior submariner experienced a mid-life transition between the ages of 30 and 35 which was typified by attributes previously discussed in the literature as well as increased responsibilities of her traditional role playing, completed family, increased leisure time, and ambivalence toward her husband's time-consuming position and her own reflected status. This paper presents case study material in illustration as well as avenues of resolution available to the woman. (Author)

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Pressurized Bow Dome of a Cable Reinforced Rubber Construction for Use with AN/SQS-26 Sonar,

The purpose of this specification is to define the fabrication of a pressurized rubber cable-reinforced bow dome window (BFG Part No. 6S-1052) for the AN/SQS-26 sonar.

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Effect of amino acid imbalance in the nutrition on the morphology of animal liver

Abstract The article considers the influence of various forms of amino acid imbalance in diets on morphological changes in the liver of laboratory animals. An imbalance of amino acids caused a number of similar changes in the liver of animals. Liver sections revealed that hepatocytes had smoothed borders and areas with signs of granular dystrophy. The sinusoids and inter-protein spaces were overflowed with blood moulds. Small groups of lymphohistiocytic cells were presented in the parenchyma. Violation of the liver microcirculation contributed to the violation of metabolic processes in hepatocytes. Most of the hepatocytes were filled with yellow-orange fat droplets and had atrophied cytoplasm with nuclei shifted to the periphery. There were single cells with glycogen granules as well. The content of nucleic acids in tissues is an important indicator of the intensity of protein synthesis. Thus, in liver sections of groups 1, 2, 3 and 4, the cytoplasm of hepatocytes was less colored than in the control group, which indirectly indicates an increase in the intensity of protein synthesis in liver cells. Hemodynamic disorders in the form of dilated blood vessels and the appearance of stasis in groups 1, 2, 3 and 4 lead to difficulties in the penetration of amino acids to the sites of protein synthesis and, as a result, to a violation of metabolic processes in parenchymal liver cells.

Topic: Biochemical effects in animals
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
An Overview of P450 Enzymes: Opportunity and Challenges in Industrial Applications

Cytochrome P450 enzymes (P450s) containing a heme-iron center, are biocatalysts from all kingdoms, involvedin a large variety of reactions. Their potential in catalyzing a broad range of substrates makes perfect candidates for biotechnology applications and the production of high-value compounds. Biocatalytic reactions performed by P450s have a great interest in the pharmaceutical industry, fine chemicals, cosmetics, and for bioremediation procedures. However, the complex nature of this protein is still a major hurdle in the prospect of using their promising ability for expanding the number of industrial applications. Multiple approaches of protein engineering are currently conducted to improve activity, stability and/or substrate specificity for a given reaction. Furthermore, in combination with the appropriate biocatalyst, a suitable bioengineering process is a key step in the implementation of P450s at the industrial scale.

Topic: Pharmacogenetics and Drug Metabolism
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Expression,purification and preliminary identification of a novel immunotoxin against hepatocarcinoma

A novel immunotoxin A54-Mel was constructed by fusing melittin,a membrane-lytic peptide and a hepatocarcinoma-specific binding peptide A54,which was screened by means of the phage display technology in vivo.The fusion gene was cloned into vector pET-32a(+) to allow soluble expression of A54-Mel as a thioredoxin(Trx) fusion protein in Escherichia coli BL21(DE3).The fusion protein was purified on His Bind Resin and cleaved by enterokinase digestion to release recombinant immunotoxin A54-Mel.Purification of A54-Mel with the purity of 95% was achieved by His Bind affinity chromatography.The expressed protein of about 21.5 kD was detected by Western blotting.In vitro analysis of the recombinant cytolytic immunotoxin(A54-Mel) demonstrated selective binding to,and cytotoxicity for live cancer cell by cell-based ELISA and MTT assays.These results suggest that the novel cytolytic immunotoxin A54-Mel can specifically bind and kill live cancer cell,which may lay a foundation for further application in targeting therapy to hepatocarcinoma.

Topic: Toxin Mechanisms and Immunotoxins
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
The auditing profession in the Netherlands: from Limperg’s principles to detailed rules

The auditing profession in the Netherlands started up at the end of the nineteenth century, with the appearance of the modern company and the separation between ownership and control. Resulting agency problems led to a major bookkeeping scandal in 1876. The management of a Rotterdam-based company called Pincoffs had forced two bookkeepers to falsify the company accounts. Instead of a loss of eight million Dutch guilders, Pincoffs reported a profit of two million guilders. However, when the company was not able to finance its current operations, the fraud was discovered. This created a need for an independent financial expert to verify the financial reports of management on behalf of the shareholders. Accordingly, in 1879 the first independent external accountant was appointed by the Nieuwe Afrikaansche Handelsvennootschap. The birth of the accounting profession was a fact. As such, the origin of the audit profession can be seen as consistent with the ideas of agency theory. In the years that followed, accountants tried to organize the profession and in 1895 established the first professional body of accountants, called Nederlands Instituut Van Accountants (NIVA). Thereafter, several other professional bodies of accountants were established, but most of them disappeared after mergers.1 This process eventually led to a situation (from 1938 on) where there were four professional bodies of accountants in the Netherlands: NIVA, Vereniging van Academisch Gevormde Accountants (VAGA), Nederlandse Unie van Accountants, and Nederlandse Broederschap van Accountants. In 1967, these four professional bodies merged into the Dutch Institute of Registered Auditors (Nederlands Instituut van Registeraccountants, or NIVRA).2 In this year the accounting profession was regulated by the 1962 Act on Registered Auditors, and the statutory auditor was officially created.3According to this act, only members of NIVRA, called Registered Auditors, were granted the right to conduct statutory audits. Furthermore, the professional body NIVRA was charged with regulating the auditing profession. They became responsible for the education and licensing of statutory auditors and the issuance of auditing standards as authorative guidance for their members. In 1993, after the implementation of the Eighth EU Directive, members of the Dutch Association of

Topic: Regulation and Compliance Studies
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences