jimnoneill/paper-to-field-training huggingface dataset:
[An analysis of related factors in thrombocytopenia combined with cirrhosis: a cross-sectional study of 2 517 cases].

<b>Objective:</b> To explore the related factors of thrombocytopenia (TCP) occurrence in patients with cirrhosis. <b>Methods:</b> A cross-sectional study was conducted. Inpatients with an initial diagnosis of cirrhosis at Peking University First Hospital from January 1, 2010 to December 31, 2020 were included. Clinical data such as demographic characteristics, etiology of cirrhosis, complications of cirrhosis, laboratory indicators, Child-Pugh grade, invasive procedures, and mortality during hospitalization were collected. A logistic regression model was used to explore the related factors of TCP occurrence in patients with cirrhosis. Categorical variables were compared by the <i>χ</i>(2) test. The inter-group comparison was performed using continuous variables, a <i>t</i>-test, one-way analysis of variance (ANOVA), or a nonparametric test. <b>Results:</b> There were a total of 2 592 cases of cirrhosis. 75 cases with incomplete clinical data were excluded. 2 517 cases were included for analysis. The median age was 58 (50, 67) years. Males accounted for 64%. 1 435 cases (57.0%) developed TCP, and 434 cases (17.2%) had grade 3-4 TCP. Gender, primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and concomitant esophagogastric varices (EGV) were the major factors associated with TCP. Females were more prone to combine with TCP (<i>OR</i>=1.32, 95%<i>CI</i>: 1.12-1.56, <i>P</i>=0.001). Patients combined with EGV (<i>OR</i>=3.09, 95%<i>CI</i>: 2.63-3.65, <i>P</i><0.001) were more prone to develop TCP, which was associated with the increased incidence of hypersplenism (<i>P</i><0.001). Patients with PBC (<i>OR</i>=0.64, 95%<i>CI</i>: 0.50-0.82, <i>P</i><0.001) and PSC (<i>OR</i>=0.23, 95%<i>CI</i>: 0.06-0.65, <i>P</i>=0.010) were less prone to develop TCP, which was due to the shorter prothrombin time and better coagulation function of PBC patients (<i>P</i><0.001), and the lower proportion of hypersplenism in combined PSC patients (<i>P</i>=0.004). Patients with TCP and grade 3-4 TCP had a higher rate of hemostatic procedures (<i>P</i><0.05), but a lower rate of liver biopsy (<i>P</i><0.05). Patients with grade 3-4 TCP had a higher nosocomial mortality rate compared to those without (<i>P</i>=0.004). <b>Conclusion:</b> TCP is common in patients with cirrhosis. However, TCP occurrence is higher in female patients with EGV and lower in patients combined with PBC and PSC. TCP affects invasive procedures and is associated with adverse outcomes.

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Supplementary Figure 3 from Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues

&lt;p&gt;Figure S3. T serves as a co-substrate of 5α-reductase but does not considerably alter the kinetics of AD metabolism in primary prostate tissues under mixed substrate conditions.&lt;/p&gt;

Topic: Sexual Differentiation and Disorders
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Triticum aestivum L. subsp. aestivum IG 78107

Plant Genetic Resource.<br>Taxonomy: Triticum aestivum L. subsp. aestivum<br>Common name(s): Wheat<br>Conserved by: International Centre for Agricultural Research in Dry Areas (ICARDA), Lebanon<br>Local sample unique identifier: IG 78107<br>Method of creation: Acquisition<br>Date: 1979<br>Other identifiers: n/a,ICBW 202912<br>Historical: No<br>Biological status: Traditional cultivar/landrace<br>MLS status: Included

Topic: Microbial Natural Products and Biosynthesis
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
CNSC-66. STRUCTURAL AND ELECTROPHYSIOLOGICAL CONNECTIVITY IN GLIOBLASTOMA IS MEDIATED BY TUMOR AND IMMUNE DERIVED CYTOKINES

Abstract BACKGROUND In glioblastomas (GBM), the pleiotropic cytokine interleukin-6 (IL-6) upregulates PD-L1 expression. This results in local immunosuppression favorable to tumor progression, and may account for the limited efficacy of immune checkpoint inhibition. Additionally, IL-6 increases synaptogenesis during development, and contributes to neuronal network remodeling following focal brain or spinal cord injury. Therefore, the aim was to determine whether IL-6 contributes to GBM-induced circuit remodeling from a structural and electrophysiological perspective. METHODS In magnetoencephalography (MEG)-based intratumoral regions of High- (HFC) and Low-Functional Connectivity (LFC) from GBM patients, the expression of IL-6 and GAP43 was compared using bulk and single-cell RNA sequencing and immunofluorescence staining in biological replicates (n=44). In mouse postnatal cortical neurons and primary patient-derived GBM cell cocultures, the expression of Ki67, GAP43, tumor connectivity and neuronal activity were monitored after exogenous application of recombinant human IL-6 (rIL-6) or microglial depletion using PLX5622. Results. IL-6 and GAP43 were overexpressed in HFC compared to LFC regions. In neuron-GBM cocultures, the tumour proliferation index was significantly increased by rIL-6 and decreased by PLX5622. Morphologically, the number of microtubes per tumor cell was significantly increased by rIL-6 and decreased by PLX5622. The expression of GAP43 was inconstantly increased by rIL-6, suggesting the regulation of other pathways involved in tumour microtube formation. Multielectrode array recordings showed a significant increase or decrease in the neuronal activity, following the addition of rIL-6 or microglial depletion, respectively. CONCLUSIONS IL-6-signaling increases proliferation, structural and electrophysiological connectivity in gliomas and may contribute to neuronal network hyper-excitability and synchrony. Microglial depletion provided opposite effects. Additional experiments are mandatory to determine whether the effects of IL-6 on GBM cells depend on the presence of microglial cells or not. These data will be critical to design new therapeutic options, likely to improve the oncological and functional outcomes of patients treated for GBM.

Topic: Lipid Membrane Structure and Behavior
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The wellbeing of families in a South African resource-constrained community

Wellbeing Theory, also known as the positive emotions, engagement, relationships,&#13;\nmeaning and achievements (PERMA) model (Seligman, 2011), proposes that there are&#13;\nfive pillars or pathways by which people can pursue wellbeing; all of which are definable&#13;\nand measurable constructs (Adler &amp; Seligman, 2016). The PERMA model incorporates a&#13;\nnumber of wellbeing theories from both subjective and objective points of view which,&#13;\naccording to Kern, Waters, Adler, and White (2014), makes it a multidimensional measure&#13;\nfor wellbeing that looks at both wellbeing feelings as well as functioning well in various&#13;\nlife domains (Huppert &amp; So, 2013).&#13;\nWhile there is a fair amount of research within the field of Positive Psychology on&#13;\nwellbeing conceptualisations and the applicability of the PERMA model within&#13;\nindividualistic societies, the applicability thereof in more collectivistic societies such as the&#13;\nperi-urban resource-constrained community of Diepsloot South Africa, is yet an area to&#13;\nbe further researched. The present study involved a secondary data analysis of existing&#13;\ndata that were collected during an EAP (Equine-Assisted Psychotherapeutic) positive&#13;\nparent workshop with a group of parents from the Diepsloot settlement in Johannesburg,&#13;\nSouth Africa. The aim of the present study was to determine whether descriptions of&#13;\nfamily life and wellbeing in Diepsloot provided by these families align with the PERMA&#13;\nmodel pathways. The findings showed that the wellbeing conceptualisations of the&#13;\nDiepsloot families overlapped with the PERMA pathways in culturally consistent ways and&#13;\nfurther showed that the PERMA model holds relevance for the South African context and&#13;\nthat it is a valuable model to be used in the identification of family assets and strengths.

Topic: Psychological Well-being and Life Satisfaction
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Transient paresis of the right recurrent laryngeal nerve after treatment with etanercept for plaque-type psoriasis.

Auteur(s) : Katharina Fiala1, Michael Schierl2, Friedrich Breier2, Robert Feldmann2, Paul G Sator2 1Dermatologist's practice H. Weltler, Hauptstrasse 4, 7000 Eisenstadt, Austria 2Department of Dermatology and Venerology, Hospital Hietzing, Wolkersbergenstrasse 1, 1130 Vienna, Austria Psoriasis vulgaris (PV) is a chronic inflammatory, T-cell-mediated autoimmune disease with a genetic background, in which TNFα plays a key role. Etanercept, a recombined human fusion protein, shows [...]

Topic: Myasthenia Gravis and Thymoma
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Contaminação cruzada: Uso de tábuas de corte na manipulação de alimentos no ambiente doméstico

The objective of this work was to carry out a bibliographical review on the approach to cross contamination in the domestic environment, using cutting boards as a tool used in food handling in domestic households, serving as a vehicle for contamination, and as interest for study, in addition to important aspects related to the safety and handling of food at home. Foodborne diseases are defined as infectious or toxic diseases caused by the consumption of contaminated food or water, and the home is considered a place of origin for these diseases based on the food handled and ingested in the home itself. The main errors during food handling are related to the hygiene conditions in the places and surfaces where these foods are handled, with cross-contamination as the main factor responsible for the transfer of microorganisms from one material or contaminated food to another. Cutting surfaces are utensils widely used in the preparation and manipulation of food, whether raw or ready-to-eat and, as handlers are unaware of adequate measures for hygiene, storage, and conservation of these surfaces, the organic matter and microorganisms present in raw foods can remain adhered to them, serving as a source of constant contamination. The permanence and adhesion of microorganisms can occur on any type of surface with the production of biofilms. Biofilms can be defined as communities of sessile cells, consisting of one or more bacterial species, included in a matrix of extracellular polymers (exopolysaccharides - EPS) adhered to an inert or living surface. Biofilms can contribute to the permanence of microorganisms on cutting boards, which may compromise the microbiological quality of food handled on these surfaces, exposing people to biological risk through the biotransfer of pathogenic microorganisms. Studies show that these pathogenic microorganisms may have some degree of resistance to antibiotics and disinfectants used in disease control and the hygiene of this utensil, and exposure to pathogens associated with their degree of resistance raises concerns for the World Health Organization (WHO), which reveals a worrying scenario for public health.

Topic: Food Safety and Hygiene
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
POWER SPECTRUM METHOD IN RECORD, EVALUATION AND PROCESSING OFGENOMIC SIGNALS

Fractals are geometrical shapes with noninteger dimension and
invariation against change of scale factor. For each
geometrical shape, one parameter - dimension - can be
calculated. For calculation, Power Spectrum Method (PSM) was
chosen. Aim of work consists in image analysis obtained from
linear sequence of DNA code. For analysis itself, sequences of
Homo sapiens Atlase and Citrobacter youngae were chosen. Result
of calculation is dimension derived from sequences of generated
texture. This result enables to introduce criterion for
sequences determination. Graphical outputs may be also
represented as multidimensional alternative transformation of
linearly recorded genomic signal. Algorithms are developed in
environment of matrix laboratory MATLAB. Origin of data is in
public database EMBL (ESI) and GenBank (NCBI).

Topic: Fractal and DNA sequence analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A study of the voluntary intake of food and water and the lactation performance of cows given diets of varying roughage content<i>ad libitum</i>

SUMMARY Twelve Friesian heifers were given four dietary treatments from 2 months before first calving to the end of the first lactation. Two of the treatments involved the ad libitum feeding of a complete diet consisting of a basal concentrate meal of rolled barley with supplements, incorporated into a mixture with either hay or barley straw both coarsely ground and included at a level of 25 % of the complete mix. In the other two treatments either the hay or the straw was given ad libitum in the long form and the concentrate mix fed ad libitum from a separate self-feeder. Full records were kept of the intake of food and water, the output and quality of the milk and of live weight. Detailed measurements were made of various aspects of rumen function using one cow on each treatment fitted with a cannula. Rumen samples were also obtained from non-fistulated cows by stomach tube. The intake of long roughage, particularly straw, by the cow, when offered in conjunction with a separate supply of the concentrate mix, was very low and led to serious falls in milk butterfat content. Where the roughage was incorporated into the complete diet normal butterfat levels were maintained. However, apart from the depressed butterfat levels on the two long roughage treatments the health and condition of the cows remained good. The very low intake of long straw was associated with a smaller volume of liquid in the rumen, a reduced rate of flow of liquid leaving the rumen, a lower proportion of acetic and butyric acids and a greater proportion of propionic acid in the rumen liquor and finally with a higher blood glucose content. The inclusion of milled roughage resulted in values within the normal range for volume of liquid in the rumen, flow rate of liquid from the rumen, V.F.A. proportions in the rumen liquor and blood glucose. The intake of both food and water over the productive cycle showed a consistent pattern for all cows. Food intake reached its lowest point around calving followed by a sharp rise to a peak in the 4th month after calving and then a gradual but increasing decline. Water intake followed a similar pattern but the fluctuation was greater and the peak consumption occurred in the 3rd month of lactation. Water intake was more closely associated with D.M. intake than with milk output. The efficiency of utilization of the complete diets containing the milled roughages is discussed in relation to comparable data from cattle fed conventionally.

Topic: Ruminant Nutrition and Digestive Physiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
961Absolute cardiovascular disease risk scores and medication use in rural India

Abstract Background Low-to-middle-income countries (LMICs) have limited resources to tackle the burden of cardiovascular disease (CVD). Most screening guidelines recommend the use of absolute risk scoring to determine treatment, but there is uncertainty among policy makers and clinicians about which risk algorithm to choose. We aimed to compare laboratory-based absolute CVD risk algorithms in a LMIC setting. Methods The study was conducted in the Rishi Valley, Andhra Pradesh, India. Over 8,000 participants were surveyed between 2012-2015. The 10-year absolute risk was computed and compared using the Framingham, WHO, and Australian absolute risk CVD algorithms. Results In participants aged 35-74 years, 151 (3%) had prior CVD. In all algorithms, absolute CVD risk increased with age and was greater in men than women. Using the WHO algorithm 4% were characterized as high-risk while &amp;gt;29% were at high-risk using the Australian risk tool. Agreement of risk classification among men ranged from a high of 84% (Spearman’s rho (rs) =0.92) between Australian and Framingham algorithms to 43% (rs=0.6) between the Australian and WHO risk scores. Among the high-risk population, only 15% were on lipid-lowering or antihypertensive therapy. Conclusions The Framingham and Australian risk scores enable some discrimination between high- and low-risk groups. However, the WHO algorithm underestimates these high-risk groups. Even though one third of the participants were at high-risk, most of them were not receiving recommended treatment. Key messages Lab-based CVD risk assessment tools have the potential in identifying high-risk populations in LMICs but the WHO risk scoring tool should be used with caution.

Topic: Global Public Health Policies and Epidemiology
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Coil-Excited Low-Frequency Waves in a Single-Ended<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>O</mml:mi></mml:math>Machine

Two modes were excited by applying oscillating currents to a small coil surrounding a plasma column in a single-ended $Q$ machine. One of them had the same dispersion relation as grid-excited waves, beyond about half a wavelength from the exciting position. The other was an electrostatic ion cyclotron wave propagating along a magnetized plasma column.

Topic: Plasma Diagnostics and Applications
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Exploring the Efficacy of Nonlinear Filters in CMOS for 2-D Signal Processing for Image Quality Enhancement

This study rigorously investigates the effectiveness of nonlinear filters in CMOS for 2-D signal processing to enhance image quality. We comprehensively compare traditional linear filters’ performance, which operate on the principle of linearity, with nonlinear filters, such as the median-median (Med-Med) approach, designed to handle nonlinear data. To ensure the validity of our findings, we use widely accepted metrics like normalized squared error (NSE), peak signal-to-noise ratio (PSNR), and structural similarity index (SSIM) to quantify the differences. Our simulations and experiments, conducted under controlled conditions, demonstrate that nonlinear filters in CMOS outperform linear filters in removing impulse noise and enhancing images. We also address the challenges of implementing these algorithms at the hardware level, focusing on power consumption and chip area optimization. Additionally, we propose a new architecture for the Med-Med filter and validate its functionality through experiments using a 9-pixel image sensor array. Our findings highlight the potential of nonlinear filters in CMOS for real-time image quality enhancement and their applicability in various real-world imaging applications. This research contributes to visual technology by combining theoretical insights with practical implementations, paving the way for more efficient and adaptable imaging systems.

Topic: CCD and CMOS Imaging Sensors
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Distribution of Enhancement of the Electric Field of Plane Wave Laser around Gold Tip Optical Antenna

This paper provides a new design of gold tip optical antenna based on a specific geometry, and then the change of enhancement of the electric field of plane wave laser excitation with 400 to 700 nm in the around of optical antenna are simulated.Changing the geometrical of light antenna includes of creating circular gratings with the period, 200,300 nm on the shaft of antenna.With the exerting of laser light to the place of these gratings .thedistribution of enhancement of the electric field in a plane perpendicular to the shaft has been acquired.Finally, the optimized value for the maximum enhancement at the period of 386.102 nm is obtained.

Topic: Semiconductor Lasers and Optical Devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
USE OF COMPUTER TECHNOLOGY AT THE STAGES OF DIAGNOSIS AND PLANNING ORTHOPEDIC TREATMENT BASED ON ENDOSSEAL IMPLANTS

This study explores the integration of computer technology in the stages of diagnosis and planning orthopedic treatment, specifically focusing on endosseal implants. With the rapid advancements in computer-aided design (CAD), computer-aided manufacturing (CAM), and three-dimensional (3D) imaging technologies, orthopedic specialists are leveraging these tools to enhance the precision and efficacy of diagnosing and planning treatments involving endosseal implants. The utilization of computer technology facilitates a comprehensive understanding of patient anatomy, enables virtual simulations for surgical planning, and ensures personalized implant design. This paper reviews the current state of computer technology in orthopedics, highlighting its applications in diagnosis and treatment planning. Additionally, it discusses the potential benefits, challenges, and future prospects of incorporating computer technology into orthopedic practices, ultimately contributing to improved patient outcomes and the advancement of orthopedic surgical techniques.

Topic: Parasitic Infections and Diagnostics
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Innovation and investment determinants of the development of the agro-food sector of Ukraine

The article develops a methodical approach to substantiate the innovation and investment determinants of the agro-food sector development. It also establishes a functional model for evaluating the innovation potential of subjects based on the innovation environment effectiveness criterion in the agro-food sector. The volume of innovation potential and costs between active enterprise groups in the livestock industry of Ukraine and EU-28 countries is determined. The study also establishes the criteria for implementing the innovation and investment development strategy for enterprises in the livestock industry of Ukraine at the macro level. The interdependence between the investment volume and the efficacy of innovation and investment processes in production is substantiated. The article concludes that the investment volume increases the innovation potential volume of enterprises of the live-stock industry in Ukraine.

Topic: Agriculture Market Analysis Ukraine
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
CCDC 2157107: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences