jimnoneill/paper-to-field-training huggingface dataset:
Spurious E rosette formation in B cell chronic lymphocytic leukemia due to monoclonal anti-sheep RBC antibody

The apparent simultaneous presence of surface markers characteristic of both B and T cells is a phenomenon being described with increasing frequency in patients with chronic lymphocytic leukemia (CLL). We describe a patient with CLL whose B lymphocytes possessed surface immunoglobulin reactive with neuraminidase-treated sheep erythrocytes (SRBCs) and produced E rosette formation. Cytofluorography using monoclonal antibodies demonstrated the B cell nature of these cells and the absence of the SRBC receptor. Further documentation that the binding of SRBCs was mediated through immunologic reaction included E rosette formation inhibition by monospecific antisera and hemagglutination of SRBCs by a paraprotein isolated from the patient's serum. Fusion of the CLL cells with a human hypoxanthine-aminopterin- thymidine-sensitive plasma cell line resulted in the production of human hybridomas that secreted the SRBC-reactive IgM antibody. An analysis of clinical histories of CLL patients whose cells exhibited this phenomenon from both immunologic and clinical perspectives is presented.

Topic: Chronic Lymphocytic Leukemia Research
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasis

<title>Abstract</title> To identify genetic events driving breast cancer progression, we performed multi-omics integrated analyses that identified overexpression of nucleoporin-93, a nuclear pore component. Here we show that NUP93 overexpression enhances trans-endothelial migration and matrix invasion in vitro, along with metastasis in animal models. These findings were supported by analyses of naturally occurring activating NUP93 mutations and inactivating nephrotic syndrome mutations. Mechanistically, NUP93 activation enhanced the ultimate nuclear transport step shared by multiple signaling pathways, including TGF-beta/SMAD, EGF/ERK and TNF/NF-κB. Likewise, NUP93 can boost nuclear transport of beta-catenin, as well as elevate expression and inhibit degradation of this co-activator. The emerging addiction to nuclear transport exposes vulnerabilities of tumors overexpressing NUP93. Congruently, we report that myristoylated peptides corresponding to the nuclear translocation signals of SMAD and ERK inhibited growth and metastasis. Our study illuminates a previously unappreciated hallmark of advanced tumors, which derive benefit from unblocking a set of nucleocytoplasmic bottlenecks.

Topic: Peptidase Inhibition and Analysis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Phytodecoration of interiors of the Government House of Ukraine: analysis and proposals

The article presents the features of bioaesthetic characteristics of decorative elements of phytodesign of the closed environment. The analysis of groups of plants by functional and aesthetic purpose in the room is carried out and on their basis project offers on improvement of features of an interior of the House of the Government of Ukraine were developed. When decorating the premises with the help of ornamental plants, the specifics of the interior design of the building and the carefully selected range of plants were taken into account, taking into account the optimal options for their placement. Aesthetic design of free space in the premises is created in order to achieve maximum comfort and coziness and the phytodesign of the closed environment copes with it best. It actively influences the nature of comfort and perception of the interior and is an important component in the design of the environment, and with its help you can increase the artistic expressiveness of the interior, improve its functional organization and, importantly, improve sanitation. The interior design of modern public office buildings is characterized by the predominance of ideas of rationalism and functionality over the aesthetic appearance of the premises. The Government House of Ukraine is the administrative building of our capital, so phytodecoration of its interiors requires careful selection of the range of plants of future phytocompositions. Today, the use of plants in the formation of interiors of various premises is due to the need of man to be closer to nature due to large-scale urbanization of cities and local man-made pollution. To successfully solve these problems requires a comprehensive approach to the wide range of uses and applications of beneficial properties of plants: volatile therapy, color therapy, aesthetic therapy, aromatherapy, ionization and many other functions. Keywords: closed space, public buildings, phytocomposition, phytodesign, phytoergonomics, project proposals.

Topic: Diverse Scientific Research in Ukraine
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
[Chronic autoimmune hepatitis following cholestatic hepatitis caused by droxicam].

Droxicam in a nonsteroid antiinflammatory from the oxicam family which acts as a pro-drug, being transformed into pyroxicam after being hydrolized in the stomach and has induced several cases of cholestatic or mixed hepatitis. A clinical observation in which droxicam provoked initial cholestatic hepatitis which later developed into chronic autoimmune hepatitis is presented. It has been postulated that, after causing cholestatic hepatitis by hypersensitivity and within the context of a previous autoimmune entity such as vitiligo, this drug triggered a silent autoimmune liver disease which was demonstrated clinical, analytical and histopathological manifestations 18 months later and required permanent immunosuppressive treatment.

Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Benefits of Flipped Learning for Developmental Mathematics

Current research shows community college students face numerous obstacles that limit their success in developmental mathematics courses. This study surveyed students to determine whether flipped learning produced differences in student engagement or factors related to passing rates compared to that of traditional teaching for different demographics of these students. The data were analyzed with mixed methods and converted to quantitative numerical values for statistical analysis, or coded qualitatively. This study revealed that flipped learning resulted in greater or no difference in student engagement, and greater feeling of respect and concern from instructors than traditional learning. Additionally, greater factors related to passing rates were revealed in young, white, able-bodied, male students. College administrators should further investigate if flipped learning would benefit students.

Topic: Innovative Teaching Methods
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Is bigger better? Dyadic and multiparty integrative negotiations

Purpose The purpose of the study is to empirically investigate the similarities and differences between dyads and four‐party groups in an integrative negotiation. Design/methodology/approach Data are collected in a between subjects experiment. A total of 182 participants completed a negotiation role play and questionnaire. Hypotheses are tested using t‐ tests, MANOVAs and two multiple regression analyses. Findings Results demonstrate that dyads do outperform groups on both the economic and subjective measures of outcomes. Sharing of priority information and the fixed pie bias was higher in groups than in dyads. For dyads the procedure used (considering more than one issue at a time) led to higher economic outcomes, and both procedure and problem solving were important for subjective outcomes. For four‐party negotiations, problem solving was significantly related to higher outcomes, on both economic and subjective outcomes, and procedure was moderately related to economic outcomes. Problem solving was significantly more important for the groups than for dyads on economic outcomes. Research limitations/implications The controlled experimental setting could limit the generalizabiltiy of the findings. Measures of the intermediate variables could be improved by including additional items and observations. Future research is required in field settings using multiple measures of the process. Practical implications In multiparty negotiation information sharing and the presence of cognitive biases may not be as important as focusing on a problem solving approach. Originality/value An empirical investigation that groups under‐perform dyads in an integrative negotiation has not been conducted before.

Topic: Conflict Management and Negotiation
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Psychosocial issues associated with being a semen donor.

Little attention has been given to the psychosocial issues associated with being a semen donor and some of the reasons for this are outlined. An extensive range of psychosocial issues is discussed. These are presented via a 'relationship model' which has been developed to illustrate how the donor, through his act of donating, is involved in a series of relationships. Some of these are interactive, in that they are two-way relationships, while others are non-reactive, being a one-way relationship only. These relationships and their impact need to be considered by, and discussed with, prospective donors. Only then will the donor and not merely his donation be responded to. Discussion of all the issues is essential if the principle of informed consent is to have any meaning. The reports of the Committees of Inquiry that have been set up in various parts of the world (as they relate to the psychosocial aspects of semen donation) are reviewed. They, along with this paper, suggest that a comprehensive service needs to be provided for semen donors and this must include consideration of the psychosocial issues. Suggestions regarding such a service are made.

Topic: Reproductive Health and Technologies
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Explaining Differences in the Environmental Performance of Countries: A Comparative Study

What influences countries' environmental performance? Do structural differences alone affect the level of air pollution? Do economic conditions determine water quality? Might society's dominant ideology and values impact national environmental performance? Are different kinds of environmental-performance indicators affected by the same variables? This paper employs comparative empirical analyses of EPI data to address these questions. Doing so enables us to contribute the following five insights to the research literature. First, we propose a conceptual categorization of EP following their health, ecological and global aspects. Second, we demonstrate that social policy, a previously underexplored factor, affects environmental policy and performance. Third, we provide evidence for the role of international engagement in explaining global-related environmental performance. Fourth, our research extends the sample studied beyond the traditional OECD sample to 68 countries with diverse development status. Finally, we demonstrate that the multiple regression models we employed provide high levels of explanatory power (up to 89%). Collectively, the results demonstrate the important role of social policy in explaining differences in the environmental performance of countries. In addition, the differences in the influence of the explanatory variables on each of the proposed category support our theoretical arguments for differentiating between various categories of environmental performance.

Topic: Energy, Environment, Economic Growth
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
FREE, ACCESSIBLE MEDIA AND QUALITY OF GOVERNMENT

In contrary to what might be expected from the results of previous research conducted on media freedom, there is a variation in both perceived corruption and quality of government (QoG) among countries with free media. This paper suggests that there is a need for complementary and more precise measures of media system characteristics in order to understand the role of the media in the fight against corruption and in promoting QoG. The purpose of this study is therefore to develop and use alternative media system measures to empirically test the relationship between media sys-tem characteristics and QoG and in what way media system characteristics can explain variations in QoG across 36 European countries. The results show that media freedom is a basic condition that is essential for media to play any role in promoting QoG. However, the results of this study also imply that accessibility and citizens’ ability to obtain information delivered by the free media are at least as important.

Topic: Media Influence and Politics
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Effect of Pulsing Treatments for Enhancing Shelf-Life of Cut Asiatic Lilium cv. Elite

Studies were conducted on cut Asiatic Lilium cv. Elite to assess the effectiveness of various floral preservatives as pulsing treatments for delaying senescence and prolonging vase life. Uniform spikes of lilium at bud colour break stage were brought to the laboratory in the morning and placed in 8 different pulsing solutions consisting of sucrose (Suc) 5%, aluminium sulphate (AS) 400 ppm, silver thio-sulphate (STS) 2.0 mM and citric acid (CA) 1000 ppm alone and in combination with sucrose. Distilled water without any chemical served as the control. Among individual treatments, STS 2.0 mM maintained better water relations and flower quality compared to others. STS also showed superiority over other treatments when combined with Suc 5% by providing largest flower size (16.74 cm) with maximum vase life (17.29 days) owing to most-favourable water relations parameters.

Topic: Flowering Plant Growth and Cultivation
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment

Recently, biofilm formation caused by bacterial adhesion and colonization has been recognized as the major cause of failure in orthopedic and dental implant surgeries. In this study, a customized micro-arc oxidation (MAO) treatment technique was developed to obtain desirable antibacterial properties on Ti surfaces. The two-step MAO treatment was applied in the fabrication of specimens with Ag and with/without Zn in their surface oxide layer. In order to simulate practical usage, surface analyses and immersion tests were performed to evaluate the incorporation of Ag and Zn into the resulting oxide layer and ion release behavior, respectively. Additionally, the antibacterial properties of the specimens after long-term immersion in physiological saline were evaluated using Gram-negative facultative anaerobic bacteria. The MAO-treated specimens containing Ag and Zn exhibited excellent antibacterial properties against Escherichia coli, which were sustained even after 6 months of immersion in physiological saline to simulate practical usage. Moreover, the Ag ions released from the surface oxide indicate the antibacterial properties of the specimen in the early stage, while the release of the corrosion products of Zn demonstrates its antibacterial properties in the later stage.

Topic: Bone Tissue Engineering Materials
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
STUDIES ON HEMOL YTICESC.HltJllICHIA COLI OF 0 139 A LETHAL SUBSTANCE FOUND IN PROLONGED CULTURE FILTRATES

Since 1938, when SCHANKS described edema disease of swine in northern Ireland, evidences have been presented by many workers that specific serotypes of hemolytic Escherichia coli are associated with the disease. For the cause of the disease, TIMONEY and other workers suggested in their reports that it is an intestinal toxemia.

Topic: Escherichia coli research studies
Subfield: Endocrinology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Velocity and abundance of silicon ions in the solar wind

Using data from the ISEE‐3 ion composition instrument (ICI), velocities and abundances of silicon ions in the solar wind have been determined. The period of investigation covers the maximum of solar cycle 21, beginning with launch of ISEE‐3 in August 1978 and ending at the removal of the spacecraft from the Lagrangian Point L1 in June 1982. The results generally confirm previous ICI observations of iron, the other heavy element with a low first ionization potential measured with the ICI. Silicon ions (and other ions in the same M/Q range) tend to stream at the bulk velocity of 4 He ++ in low‐speed solar wind. At high‐speed solar wind, Si lags by up to or about 20 km/s after 4 He ++ . By means of a minimum variance estimation technique, fluxes (and densities) of silicon in the solar wind have been obtained free of bias. An average Si/O flux ratio of 0.19±0.04 is derived. This value is larger by a factor of 3 or 4 than the Si/O abundance ratio at the solar surface.

Topic: Solar and Space Plasma Dynamics
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Class, gender, and ritual puppetry: negotiating revival for the hakomawashi puppeteers of Tokushima, Japan 1

This chapter looks at the hakomawashi puppet tradition in Tokushima, Japan, in which puppeteers go house to house (kadozuke) at New Year, blessing homes with the puppet figures Okina, Senzai, Sanbas{obar}, and Ebisu. It focuses specifically on the role of a small group of women in the form's current revival. While some parts of the tradition may have been off limits to women in the past or viewed with suspicion if performed by women, today it is a woman who is its central performer, thanks to her unique heritage and devotion to the art. Her work connects to a long history in Japan both of women being associated with spiritual powers and of rituals being performed with puppet-like figures. Hakomawashi have traditionally held outcast status (burakumin). Today's hakomawashi promote the rights of the outcast class, as they lift the form from the social stigmas previously associated with it.

Topic: Japanese History and Culture
Subfield: Cultural Studies
Field: Social Sciences
Domain: Social Sciences
Climate change from the lens of Malolos children: perception, impact and adaptation

Purpose The purpose of this paper is threefold: first, to understand how Filipino children perceive climate change; second, to determine how children themselves adapt to its impacts; and third, to identify the level of support available at the household, community, and city levels as children adjust to their changing environment. Design/methodology/approach A qualitative study was conducted in three peri-urban communities in Malolos, Philippines, looking at the perception and adaptation mechanisms of children in the face of climate change, using Lazarus and Folkman’s typology for children’s coping strategies in stressful situations. The support that children receive at the household, community, and city levels was also examined. Findings Climate change has impacted the daily lives of children, aggravating in particular the “everyday” and “invisible” risks of those who belong to poor households. In general, emotion-focused coping that hinges on denial or distancing did not seem to be prominent among children; many of them were rather pre-disposed to problem-focused coping as they try to cope with the impacts of climate change in their immediate environment. Unfortunately, however, interventions to mitigate the impacts of climate change on children at the household, community, and city levels were found to be lacking. Research limitations/implications The selected communities do not represent the wide spectrum of localities in the Philippines. At best, findings from the small sample size provide only a snapshot of the conditions of children living in peri-urban areas. Practical implications The study points to the need for child-sensitive climate change adaptation at the household, community, and city levels to support the coping mechanisms of children. Originality/value The study adopts a multi-level approach at understanding the impacts of climate change on Filipino children and the interventions that they and other social institutions have undertaken in response thereto. Findings add empirical evidence to growing literature on the subject, especially in the context of the Philippines where academic studies on the matter remain scant.

Topic: Climate Change, Adaptation, Migration
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
<i>A Caprice</i> – The Summit of Ibsen’s Theatrical Career

Erik Bogh’s A Caprice (En Kaprice) premiered 7 September 1859 at the Norwegian Theatre in Christiania (Oslo), staged by theatre manager Henrik Ibsen. The production then ran for another 35 performa...

Topic: Theatre and Performance Studies
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Impedance of a Rigid Piston in an Infinite Rectangular Array of Pistons

A general solution is obtained for the velocity potential due to an infinite rectangular array of rigid pistons in a plane, rigid baffle. It is formed by a superposition of a double infinity of plane waves. For a given wave, corresponding to index (m. n). the mass reaction of the fluid increases monotonically with frequency to an infinite value at a critical frequency; the wave is propagated parallel to the plane of the array. Above the critical frequency the reaction of the fluid is resistive and decreases monotonically with frequency from infinity at the critical frequency; the direction of propagation has a component, which increases with frequency, perpendicular to the plane. The pressure due to each wave is integrated over any piston, and the total impedance is obtained by summing for all waves. Results are graphed for impedance versus frequency for a class of piston sizes and spacings.

Topic: Advanced Thermodynamic Systems and Engines
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Longitudinal study of the protective effect of hope on reducing body image distress in cancer patients

Body image distress is well-documented in patients with cancer, but little is known about the course of body image distress over time and the role of psychosocial resources such as hope. This prospective study sought to explore the dynamics between trajectories of body image distress and hope across time. Cancer patients receiving outpatient treatment at a cancer center completed self-reported measures of body image distress (Body Image Scale) and hope (Adult Hope Scale) at baseline (within three months of their cancer diagnosis) and follow-up (six months post-baseline; N = 111). Trajectories of intra-individual change (improved, stable, and declined) for body image distress were calculated based on the minimal clinically important difference (±0.5 baseline SD). There was a significant increase in body image distress at follow-up (p < .05); hope remained stable. Rank-transformed mixed-factor repeated measures analyses of variance revealed significant interactions between body image distress trajectory groups and time on hope, suggesting that patients experiencing improvements in body image distress reported higher levels of hope than those who had stable or deteriorating levels of body image distress F(2,108) = 3.25, p < .05. The findings of this exploratory study suggest that psychosocial resources like hope may also reduce body image distress across time in a sample of cancer patients, although the mechanisms of interaction require further examination. Supportive care could lend greater focus to improving patients' hope to alleviating body image distress.

Topic: Optimism, Hope, and Well-being
Subfield: Applied Psychology
Field: Psychology
Domain: Social Sciences