jimnoneill/paper-to-field-training huggingface dataset:
Synergistic rescue of temperature‐sensitive p53 mutants by hypothermia and arsenic trioxide

Abstract The p53 tumor suppressor is inactivated by mutations in about 50% of tumors. Rescuing the transcriptional function of mutant p53 has potential therapeutic benefits. Approximately 15% of p53 mutants are temperature sensitive (TS) and regain maximal activity at 32°C. Proof of concept study showed that induction of 32°C hypothermia in mice restored TS mutant p53 activity and inhibited tumor growth. However, 32°C is the lower limit of therapeutic hypothermia procedures for humans. Higher temperatures are preferable but result in suboptimal TS p53 activation. Recently, arsenic trioxide (ATO) was shown to rescue the conformation of p53 structural mutants by stabilizing the DNA binding domain. We examined the responses of 17 frequently observed p53 TS mutants to functional rescue by temperature shift and ATO. The results showed that ATO only rescued mild p53 TS mutants with high basal activity at 37°C. Mild TS mutants showed a common feature of regaining significant activity at the semi‐permissive temperature of 35°C and could be further stimulated by ATO at 35°C. TS p53 rescue by ATO was antagonized by the cellular redox mechanism and was rapidly reversible. Inhibition of glutathione (GSH) biosynthesis enhanced ATO rescue efficiency and sustained p53 activity after ATO washout. The results suggest that mild TS p53 mutants are uniquely responsive to functional rescue by ATO due to small thermostability deficits and inherent potential to regain active conformation. Combining mild hypothermia and ATO may provide an effective and safe procedure for targeting tumors with p53 TS mutations.

Topic: Epigenetics and DNA Methylation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SOCIO ECONOMIC STATUS OF AGRICULTURAL HOUSEHOLDS: A STORY OF TWO VILLAGES OF TRIPURA

Based on the primary field survey and secondary sources of data this study analyzes the scenario of the agriculture sector of Tripura and the socio-economic status of the agricultural households of two blocks of the North Tripura district of Tripura. The secondary sources of information shows that the state is facing the crisis of food grains and other crops due to increasing trends of population. The primary filed survey data explores that most of the members of the agricultural households are primary school educated. The work participation rate is inversely related with different income group in both the study villages. We also see that middle income groups have commend over the livestock assets. From the field level analysis it is found that most of the agricultural households not survive with their tiny portion of cultivated land. Cultivation is not sufficient to maintain their family in proper way. Some members of the agricultural households are engaged with some small business, some other non-farm employment and government sponsored work like MGNREGA activity. For the improvement of the socio economic condition of the agricultural households this study suggests for government intervention to give credit facilities to the cultivators for their cultivation and other non-farm activities. This study also suggests for proper use of the unused land for the cultivation of some cash crops and use of proper water resources for fish cultivation. The study also provides recommendation for enhancing asset creation and sustainability of assets for wider benefit of the rural community through the MGNREGA activity of local Self Governments.

Topic: Agricultural Economics and Practices
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Efficacy of Adalimumab for Pediatric Vogt-Koyanagi-Harada Syndrome

Pediatric Vogt-Koyanagi-Harada syndrome (VKH) is rare, with limited cases of corticosteroid-sparing immunosuppression use reported. A 15-year-old Hispanic girl was referred for bilateral intraocular inflammation. Her initial best corrected visual acuity (BCVA) was 20/30 in the right eye and 20/200 in the left eye, with granulomatous keratic precipitates, anterior chamber and vitreous cell, optic disc edema, and nummular depigmented chorioretinal lesions on examination consistent with VKH after an unrevealing work-up. Inflammation was recurrent despite oral prednisone and methotrexate. Adalimumab, a TNF-alpha inhibitor, led to rapid resolution of inflammation, successful dose reduction of prednisone and methotrexate, and final BCVA of 20/25 in the right eye and 20/40 in the left at 26-month follow-up. [ Ophthalmic Surg Lasers Imaging Retina . 2014;45:332-333.]

Topic: Ocular Diseases and Behçet’s Syndrome
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
ANAEROBIC GLYCOLYSIS IN RAT OVARIAN TISSUES DURING PREGNANCY AND LACTATION<sup>1</sup>

Several reports have been made from this laboratory on the changes in the activities of certain enzymes in ovarian tissues of the rat during different phases of the reproductive cycle. The adenosine triphosphatase activity of corpora lutea and the remaining ovarian tissues has been studied (Biddulph, Meyer and McShan, 1946a, 1946b) as well as the succinic dehydrogenase (Meyer, McShan and Erway, 1945; Meyer, Soukup, McShan and Biddulph, 1947), malic dehydrogenase (McShan, Erway and Meyer, 1948) and the acid and alkaline phosphatases (Stafford, McShan and Meyer, 1947). Recent advances in the manometric determination of anaerobic glycolysis of tissue homogenates (Racker and Krimsky, 1945; Utter, Reiner and Wood, 1945; and Novikoff, Potter and LePage, 1948) have made it feasible to determine the anaerobic glycolysis of ovarian tissues during pregnancy and lactation in the rat. The method used was essentially that of the latter workers.

Topic: Birth, Development, and Health
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Nanostructured Au(111)/Oxide Epitaxial Heterostructures with Tailoring Plasmonic Response by a One-Step Strategy

In this work, we present a strategy for developing epitaxial incommensurate nanostructured Au/oxide heterostructures with tunable plasmonic response. Previously, high-quality single-phase and single-oriented alfa-Fe2O3(0001) thin films were achieved, which have been used as a template for noble-metal epitaxial deposition. The complex systems have been grown by pulsed laser deposition on two different types of oxide substrates: alfa-Al2O3(0001) and SrTiO3(111). A one-step procedure has been achieved tailoring the isolated character and the morphological features of Au nanostructures through the substrate temperature during Au growth, without altering the structural characteristics of the hematite layer that is identified as a single iron oxide phase. The epitaxial character and the lattice coupling of Au/oxide bilayers are mediated through the sort of oxide substrate. Single-oriented Au(111) islands are disposed with a rotation of 30° between their crystallographic axes and those of alfa-Fe2O3(0001). The Au(111) and SrTiO3(111) lattices are collinear, while a rotation of 30° happens with respect to the alfa-Al2O3(0001) lattice. The crystallographic domain size and crystalline order of the hematite structure and the Au nanostructured layer are dependent on the substrate type and the Au growth temperature, respectively. Besides, the functional character of the complex systems has been tested. The localized surface plasmons related to Au nanostructures are excited and controlled through the fabrication parameters, tuning the optical resonance with the degree of Au nanostructuring.

Topic: Iron oxide chemistry and applications
Subfield: Renewable Energy, Sustainability and the Environment
Field: Energy
Domain: Physical Sciences
The Treatment of Leprosy

From whatever standpoint leprosy is viewed, whether from that of the clinician or the epidemiologist, the objective must be to diagnose and treat the maximum number of leprosy patients, not only because the disease is curable but because treatment renders ' open ' cases non-contagious long before cure is obtained. Now that it is becoming generally accepted that the way to leprosy eradication lies through case-finding and treatment, an increasing responsibility falls upon doctors working in the tropics to undertake the treatment of leprosy in hospital or rural clinic out-patients, for facilities in leprosy hospitals (leprosaria) are far too limited to deal with the numbers of patients involved, and, in any case, admission to leprosaria should not be indiscriminate but should be restricted to cases where special social or medical indications exist.5 At present there are about 2II,900 leprosy inpatients throughout the world, but seven times as many are receiving out-patient treatment, and on the estimated world incidence of IO-I2 million leprosy sufferers, there are at least seven undiagnosed and untreated patients for every one under treatment.5 It is apparent, therefore, that in countries where leprosy is highly endemic, doctors without previous special training are likely to be called upon to shoulder the responsibility of treating leprosy out-patients, making use of the services of a leprosy specialist when difficulties arise, and it is for doctors such as these that this paper has been written.

Topic: Leprosy Research and Treatment
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.

Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work. The evaluation of HIV inhibitory activity demonstrated that all compounds were potent against HIV-1 replication. The most active compound 7c exhibited activity against HIV-1 (IC50 = 0.034 micromol x L(-1), SI = 6,475) and the double mutant strain (IC50 = 9.39 micromol x L(-1)) in the micromolar range, which was more potent than nevirapine.

Topic: HIV/AIDS drug development and treatment
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
[Effect of the combination of bushen xuguan recipe and ruanjian huayu recipe on the MMP-2 expression in endometriosis rats].

The occurrence of EMS was correlated with increased activities of MMP-2. The combination method could inhibit the activities of MMP-2 in the ectopic endometrial tissues of EMS rats more effectively than RHR alone, which might be achieved through improving the endocrine environment, and reducing the "invasion" capability of the ectopic endometrium.

Topic: Endometriosis Research and Treatment
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Validated\nModeling for German White Wine Varietal\nAuthentication Based on Headspace Solid-Phase Microextraction Online\nCoupled with Gas Chromatography Mass Spectrometry Fingerprinting

An untargeted analytical approach\ncombined with chemometrics using\nthe volatiles of German white wine was investigated regarding the\nusefulness for verifying botanical origin. A total of 198 wine samples\nof Riesling, Müller-Thurgau, Silvaner, Pinot Gris, and Pinot\nBlanc were examined applying headspace solid-phase microextraction\nonline coupled with gas chromatography mass spectrometry. The resultant\nthree-dimensional raw data were processed by available metabolomics\nsoftware. After data treatment, a partial least-squares discriminant\nanalysis (PLS-DA) model was validated. External samples were correctly\nclassified for 97% Silvaner, 93% Riesling, 91% Pinot Gris/Blanc, and\n80% Müller-Thurgau. This model was related to monoterpenoids,\nC&lt;sub&gt;13&lt;/sub&gt;-norisoprenoids, and esters. Further, 100% prediction\nfor a two-class model of Riesling versus Pinot Gris/Blanc was confirmed\nby 74 additional samples measured independently. Hence, the strategy\napplied was, in particular, reliable and relevant for white wine varietal\nclassification. In addition, the superior classification performance\nof the Riesling class was revealed.

Topic: Genetic and Environmental Crop Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
213. Regulation of TGFβ superfamily-related genes in the newborn mouse testis by activin

Several members of the transforming growth factor-β (TGFβ) superfamily of ligands are known to influence development of male germ cells. In our ongoing investigations of genetically modified mice with different bioactive levels of activin, we noted that testicular germ cell numbers at birth are increased in the absence of activin.1 In this study we compared expression levels of TGFβ-related genes in mice with 0, 1 or 2 copies of the activin βA subunit gene. Candidate genes were identified through hybridisation of total testis RNA from newborn (Day 0) wild type (WT; 2 copies) and activin βA null mice (KO; 0 copies) to a TGFβ SuperArray Simplicity™ membrane. Densitometric analysis of resulting signals revealed several genes that appeared to differ between genotypes. To validate these findings, pooled testes from newborn WT (2 independent groups), heterozygous (het; 2 groups) and activin βA KO (3 groups) mice were collected for RNA extraction. Quantitative real-time PCR analysis was performed using the Roche Light Cycler, with β-actin mRNA level used as the housekeeping reference. The mRNAs selected for analysis were: inhibin α, p15INK4b, Smad5, insulin-like growth factor 1 (IGF-1), ALK6 (BMPRI-B), and tissue inhibitor of metalloproteinase 1 (Timp1). The inhibin α transcript level was significantly decreased in the activin βA KO animal compared with WT, while the het sample showed an intermediate effect. Both Smad5 and IGF-1 transcripts appeared to increase in the KO animals compared with WT; however, the cyclin-dependent kinase inhibitor, p15INK4b, did not change significantly across the genotypes. Similarly, ALK-6 and Timp1 mRNA levels were also unaffected by genotype. These findings illustrate the impact of graded levels of activin A on specific genes in the fetal testis. (1)Mendis et al. (2004). Reprod. Fertil. Dev. 16(Suppl.), 103.

Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Narrating Silence: Gerhard Roth's <i>Am Abgrund</i>

Gerhard Roth's novel from 1986, Am Abgrund , stands at the center of hismonumental and multi‐genre cycle, Die Archive des Schweigens . On one level, the novel can be read as an allegory of modern Austria, which Roth has called a “Reich des Schweigens.” Its main protagonists—the mute, ostensibly insane Lindner and the law student‐cum‐murderer Jenner—could represent the twinned dimensions of post‐war Austrian silence: guilt and trauma. More broadly, Am Abgrund enacts a post‐rational subjectivity that is dispersed over a ground of multivalent and supremely powerful silence. Narrative agency, scattered among multiple figures, is attenuated to the point of nearly disappearing. Roth has said “das Untersuchen ist eine Krankheitvon mir,” an illness he shares with the novel's third protagonist, the magistrate Sonnenberg. But through this pathologically tinged compulsion, Roth's fiction ultimately makes present a mute reality that can only be traced and silhouetted, but never penetrated, by language.

Topic: German History and Society
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
IQTIDAR ALAM KHAN. Gunpowder and Firearms: Warfare in Medieval India. (Aligarh Historians Society Series.) New York: Oxford University Press. 2004. Pp. xiv, 263. $35.00

Journal Article Iqtidar Alam Khan. Gunpowder and Firearms: Warfare in Medieval India. (Aligarh Historians Society Series.) New York: Oxford University Press. 2004. Pp. xiv, 263. $35.00 Get access Iqtidar Alam Khan. Gunpowder and Firearms: Warfare in Medieval India. (Aligarh Historians Society Series.)New York: Oxford University Press. 2004. Pp. xiv, 263. $35.00. Douglas E. Streusand Douglas E. Streusand U.S. Marine Corps Command and Staff College Search for other works by this author on: Oxford Academic Google Scholar The American Historical Review, Volume 111, Issue 3, June 2006, Pages 817–818, https://doi.org/10.1086/ahr.111.3.817 Published: 01 June 2006

Topic: Politics and Conflicts in Afghanistan, Pakistan, and Middle East
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Canada as a selective power : Canada's role and international position after 1989

The monograph "Canada as a selective power" presents authors' own perspective on Canada's contemporary foreign policy and on its position and role(s) in the dynamically changing international affairs. In the book, the authors argue that since 1989 Canadian foreign policy has moved from the more modest aims of a "middle-power" to a more self-assertive role of a "selective power" pursuing more narrowly chosen priorities - and often based on "simple profit and loss calculations" that have clashed with Canada's traditional favorable image in the world.

Topic: Canadian Policy and Governance
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Factors controlling the activity and selectivity of conversion of cyclohexane in the presence of hydrogen over ruthenium supported on alumina

The effects of Ru dispersion (or particle size) and residual Cl of Ru/Al2O3 on the catalytic activity and the selectivity for the cyclohexane conversion in the presence of hydrogen were investigated. In the case of Cl-free Ru/Al2O3 prepared from Ru3(CO)12, the turnover frequency (TOF) of hydrogenolysis was greater for higher Ru dispersion, and that of dehydrogenation was nearly independent of the dispersion, where TOF was calculated on the basis of H2 adsorption, i.e. the selectivity depends on the Ru dispersion. For Cl-containing Ru/Al2O3 catalysts, which were obtained from RuCl3 or by the addition of Cl to the Cl-free Ru/Al2O3, the dispersion–TOF correlations were different from those of the Cl-free Ru/Al2O3. Consequently, the selectivity oppositely depended on the Ru dispersion for the Cl-free and the Cl-containing Ru/Al2O3. The dispersion and the residual Cl were the crucial factors controlling the activity and selectivity, and these effects were differentiated.

Topic: Catalysts for Methane Reforming
Subfield: Catalysis
Field: Chemical Engineering
Domain: Physical Sciences
Effect of reused water on growth index and survival rate of the Rainbow trout (Oncorhynchus mykiss)

This research was carried out to determine water reuse effects on growth indices of rainbow trout. For this reason 4 groups including: Control (with use of 100% fresh water), Test 1(rearing with use of 30% recycled water (with physical filtration and 10% fresh water), Test 2 (using of 10% recycled water (with physical filtration and 30% fresh water), Test 3(using of 100% recycled water) was done. Fish stock of each groups were done with 62 fish in each square meter and average (Â±SD) weight (15Â±1.5). The Growth index, SGR, CF, FCR, SR between different groups in each month was calculated and determined. In this research comparing the average of monthly growth increasment between different groups indicated that significant decrease of growth in test groups with control group as well as groups 1 and 2 with 3 groups. There were no significant differences in this factor between groups 1 and 2. FCR, SR and MR showed a significant difference between different groups. These results showed with increasing the replacement of water in rainbow trout culture ponds with recycled water cased significant decrease in SR and CF and significant increase in MR and finally decrease in production and density per unit area.

Topic: Fish Biology and Ecology Studies
Subfield: Aquatic Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
An Eclipse-based Software Platform for the Recoding Integrated Development (RIDE)

With the increasing abstraction level of embedded system models, System Level Description Languages(SLDL), like SystemC or SpeC, have been increasingly used as the design entrance. Having a well described system level model, tools can gradually synthesize them into lower level until the final netlist implementation. However, accompanying with the increase of design ability, new bottlenecks are generated. Many of the system level models are recoded from legacy C reference code, and most of the recoding is nowadays done manually by designers. Due to tedious work, this process is error-prone, time-consuming, and the quality of the final system level model is unstable. This problem has been addressed by a designer-controlled Recoding Integrated Development Environment (RIDE). With both a textual and a graphic editor and a set of analysis and transformation tools, the designer can re-code C reference code into a system level model more efficiently. In this report, we describe an Eclipse-based software platform for RIDE which can serve as a robust and extensible framework for RIDE software development and implementation. We describe in detail the initial software package installation and outline paths for its extension

Topic: Embedded Systems Design Techniques
Subfield: Hardware and Architecture
Field: Computer Science
Domain: Physical Sciences
Uncovering a New Concept of Foodnality in Diet Recommendations for Chinese Aging Populations Based on Systematic and Bibliometric Review

China is grappling with significant aging challenge, and food patterns play an important role in the health of aging populations. A comprehensive bibliometric analysis with regard to systematically examined population-based studies published between 1 June 2014 and 31 May 2024, and 83 eligible studies, including 43 cross-sectional, 34 longitudinal, and 6 case–control studies, was conducted to investigate the correlations among foods, dietary patterns, and healthy aging concepts. An interesting conclusion from cohort studies was that foods recommended for intake in certain diets might not be recommended in other diets, i.e., food items in various diets showed different contributions. This dual character of foods exhibited in the diet is termed foodnality, a new concept proposed in this study. Foodnality was partially related to the origins, quality, and processing of foods, as well as individual physical status. Therefore, recommended foods with positive foodnality and unrecommended foods with negative foodnality were summarized, and four-dimensional diet recommendations were further proposed, including choosing a suitable dietary pattern, evaluating positive foodnality, upgrading foodnality to a premium diet, and cultivating healthier dietary concepts. This review plays a pivotal role in evaluating the guidelines on food intake and dietary patterns among elderly residents in China.

Topic: Nutritional Studies and Diet
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Electronic Behavior of Calcined Material from a (Niobium-O-Phenylene-S) - (Cadmium-S-Phenylene-O) Hybrid Copolymer

(ニオビウム-O-フェニレン-S) - (カドミウム-S-フェニレン-O) 共重合体をアルゴン雰囲気下で焼成し, Nb2O5/炭素クラスター/CdS複合体を得た。ESRスペクトル測定の結果から, 本焼成体はNb2O5-炭素クラスター→CdS→炭素クラスターへの連鎖的電子移動を誘発していることが示唆された。

Topic: Conducting polymers and applications
Subfield: Polymers and Plastics
Field: Materials Science
Domain: Physical Sciences
Protocols in Esthetic Implant Restoration

インプラント修復において審美性を考慮する場合，歯冠修復と同様に辺縁歯肉と歯冠乳頭の位置，およびその長期的安定が問題となる．このことに関するリサーチは1990年代から2000年代に数多く見られるが，これらの研究は1980年代から広く知られるインプラント埋入後に起こる周囲硬組織の変化に起因する見かけの変化をリサーチしたに過ぎないように思える．つまり，インプラント修復において審美性を確立するためには，従来からいわれているインプラント埋入部位に必要な硬組織を確保，または造成することである．生体には固有差があるが，一般的にはインプラントの頬（唇）側および舌（口蓋）側に2 mm以上，インプラントと天然歯間に1.5 mm以上，インプラントとインプラント間に3 mm以上の硬組織を確保し，辺縁歯肉より3 mm根尖側方向にインプラントが位置するよう埋入することが，インプラント修復を審美的に完結できるのではないかと多くの文献から示唆される．

Topic: Dental Implant Techniques and Outcomes
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences