jimnoneill/paper-to-field-training huggingface dataset:
Serial Changes of Intrathecal Viral Loads Evaluated by Chemiluminescence Assay and Nested PCR with Aciclovir Treatment in Herpes Simplex Virus Encephalitis

Evaluation of intrathecal viral antigens by the CL has a potential for estimating the effects of antiviral therapy, as does evaluation of the intrathecal HSV-DNA by the nested PCR. The intrathecal viral loads evaluated by CL and nested PCR were not a predictor of outcome in HSVE.

Topic: Herpesvirus Infections and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
[Cystic lesions of the pancreas].

The number of the literature and classification of the cystic pancreatic diseases is increasing recently. We describe MR cholangiopancreatography (MRCP) findings of the cystic pancreatic diseases according to the clinical oriented classification. Intraductal papillary tumor, mucinous cystadenoma and serous cystadenoma showed characteristic MRCP findings. However small non-neoplastic true cysts are difficult to differentiate from cystic tumors even by MRCP.

Topic: Pancreatic and Hepatic Oncology Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Bayesian nonparametric multivariate convex regression

In many applications, such as economics, operations research and reinforcement learning, one often needs to estimate a multivariate regression function f subject to a convexity constraint. For example, in sequential decision processes the value of a state under optimal subsequent decisions may be known to be convex or concave. We propose a new Bayesian nonparametric multivariate approach based on characterizing the unknown regression function as the max of a random collection of unknown hyperplanes. This specification induces a prior with large support in a Kullback-Leibler sense on the space of convex functions, while also leading to strong posterior consistency. Although we assume that f is defined over R^p, we show that this model has a convergence rate of log(n)^{-1} n^{-1/(d+2)} under the empirical L2 norm when f actually maps a d dimensional linear subspace to R. We design an efficient reversible jump MCMC algorithm for posterior computation and demonstrate the methods through application to value function approximation.

Topic: Markov Chains and Monte Carlo Methods
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
The demand for retailer‐financed instalment credit: An econometric analysis

Abstract During the mid‐ to late 1980s the UK's Chancellor of the Exchequer has attempted to reduce the volume of consumer credit extended by increasing interest rates rather than by re‐introducing terms controls. This paper presents estimates of demand functions for new credit extended by retailers which was financed by them and repaid by instalments. Following earlier papers, a stock‐adjustment model is presented that is extended to allow for credit rationing. The results suggest that the demand for such new credit extended is related negatively to terms control and positively to personal disposable income and expectations. Demand was not found to be related to (a proxy for) the nominal interest rate charged by retailers (although it was found to be positively related to the real rate). The former finding is consistent with questionnaire evidence that consumers are unaware of the interest rate that they pay for credit. Elasticities of demand are presented.

Topic: Housing Market and Economics
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION

Purpose: To investigate the Stargardt disease phenotype associated with an unusually common and “extremely hypomorphic” ABCA4 variant, p.N1868I. Methods: The charts of 27 patients with p.N1868I on one allele and a severe/deleterious mutation on the other allele were reviewed. Subjective age of onset, best-corrected visual acuity, and stage of disease were recorded for all 27 patients, 18 of whom had multiple visits. When available, fundus photography, spectral domain optical coherence tomography, fundus autofluorescence, full-field electroretinograms, Goldmann visual fields, and fluorescein angiography were included. Five families with multiple affected members were analyzed. Results: The median age at symptom onset was 41.5 years, and 3 p.N1868I patients had not developed visual symptoms as of the most recent eye examination. Median best-corrected visual acuity in the better-seeing eye at baseline was 20/25 −2 , and the median duration from symptom onset to legal blindness was 25 years. The five families described in this study demonstrated clinically significant intrafamilial variability, and affected family members who did not share the p.N1868I variant had relatively more severe phenotypes. Conclusion: This study demonstrates the consistency of foveal sparing, the variation in age at onset, the intrafamilial variability, and the prognosis with regard to visual acuity in p.N1868I-associated Stargardt disease.

Topic: Retinal Development and Disorders
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Fully-Computerized Studio

The use of remote camera-control systems for news studios, enabling an operator to reposition the camera and recall preprogrammed positions remotely, is well established. By expanding camera-control systems to include the capability to control other broadcast machines, substantial production cost savings can be made. This article examines the principal features of an integrated machine and camera-control system, starting with some design aspects of servo-controlled pan-and-tilt heads and communication techniques and concluding with examples of systems for use in news studios and legislatures.

Topic: Experimental Learning in Engineering
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
The relationship between moral intelligence and demographic features of Payame Noor University students of Khoy and Mahabad with special emphasis on Quranic and psychological teachings

For downloading the full-text of this article please click here. Background and Objective: Through efficient use of intelligence capacity, thinking, and effective training, moral intelligence can play a significant role in all walks of human life. The current study aimed to explore the relationship between moral intelligence and demographic features of Payame Noor University students of Khoy and Mahabad. Method: The study adopted a descriptive-correlational design and was conducted following a cross sectional procedure in 2017 among Payame Noor University students of Khoy and Mahabad. The statistical population comprised all students studying at these two universities. Out of them, 101 students were selected from different fields of study through stratified random sampling. The data were collected using a two-section survey; the first section gathered information about the participants’ demographic characteristics such as gender, age, marital status, and the educational center. The second section comprised Lennick and Kiel’s moral competency inventory (MCI). The reliability of this inventory was found to be 0.86 using Cronbach’s alpha. All ethical issues were observed in this study and the researchers did not declare any conflict of interests. Results: The mean score and standard deviation of the students’ moral intelligence were 71.1 and 10.5 respectively, which indicates their acceptable level of moral intelligence. Furthermore, older students enjoyed higher levels of moral intelligence in comparison with their younger counterparts. Significant associations were also observed between moral intelligence subscales and some demographic features of the students. Conclusion: Identifying and using some methods to enhance students’ moral intelligence can result in their positive attitude and eventually lead to richer general culture and improvement in their performance. Thus, attempts to identify and nurture moral intelligence subscales have a critical impact on students’ educational, professional, and family-related future. For downloading the full-text of this article please click here. Please cite this article as: Shahandeh A, Abdoljabbari M, Olyanasab SZ, Rahmani R. The relationship between moral intelligence and demographic features of Payame Noor University students of Khoy and Mahabad with special emphasis on Quranic and psychological teachings. J Res Relig Health. 2019; 5(3): 72- 83. doi: https://doi.org/10.22037/jrrh.v5i3.20900.

Topic: Emotional Intelligence and Performance
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Exploring seasonal accumulation bias in a west central Greenland ice core with observed and reanalyzed data

Abstract The seasonality of accumulation in west central Greenland is investigated to determine whether a summer bias exists in a multi-century ice core recovered from Crawford Point (CP). Such a bias would negatively affect the ice core’s potential for reconstructing the history of winter circulation patterns including the North Atlantic Oscillation. An automatic weather station (AWS) installed at the CP site in 1995 records sub-daily surface heights and affords a unique opportunity to assess the seasonal distribution of accumulation and test the performance of five gridded reanalysis datasets and a regional climate model. Simulated accumulation compares remarkably well with in situ measurements from both the AWS and CP ice core, demonstrating their potential to accurately represent accumulation in this region. Seasonal accumulation exhibits no summer maximum, indicating that any concurrent precipitation maximum is likely offset by melt and/or sublimation effects. The lack of a strong seasonal accumulation bias implies that the CP ice core is well suited for future investigations of the history of winter circulation patterns.

Topic: Climate variability and models
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
A Dbuble-Blind,. Randomized, Placebo-Controlled T rial of Divalproex Extended-Release in the Treatment of Bipolar Disorder in Children and Adolescents

Objecii~e: To compare the efficacy and safely or divalprOB) ( extended-release (ER) to placebo in a 28-day double-blind sludy of bipolar disorder In children and adolescenls and evaluate the safety of divalproex ER in a 6-monlh open-tabel extension study. ~ethod: In the double-blind study, 150 patients (manic or mixed episode, aged 10-17 years) with baseline Young ·Mania Rating Scale (YMRS) scare 01 20 or higher were randomized to once-daily placebo or divalproex EA, which was titrated 10 clinical response or serum valproale concentralion of 80 10 125 tJglmL Sixty-six patients enrolled in the extension study. Results: In the double-blind study, a treatment effect was not observed with divalproex ER based on change in mean YMRS score (divalproex ER-B.B [n = 74]; placebo-7.9 [n =70]) or secondary measures. Divalproex was similar to placebo based on incidence of adverse events. Four subjects trealed with divalproex ER and three treated with placebo discontinued because of adverse events, Mean ammonia levels increased in the divalproex EA group. but only one p&amp;apos;alient was symptomatic. In the long-term study, YMRS scores decreased modestly (2_2 points from baseline). The most common adverse events were headache and vomiting. Conclusions: Th&amp;apos;e results of the study do not provide support for the use of divalproex ER in the trealment of youths with bipolar r disorder, mixed or manic stale. Further controlled trials are required to confirm or refute the findings from this study. J. Am. Acad. Child Adolesc. Psychiatry,

Topic: Bipolar Disorder and Treatment
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Oral iron chelation is here: Author's reply

LI may outweigh the risks of its possible toxicity, and its introduction in such patients may now be appropriate" seem overenthusiastic.Certainly it is in stark contrast to an earlier editorial in the Lancet, which questioned the efficacy of LI and drew attention to the unacceptable incidence of side effects, recommending that "this compound should no longer be given to patients."4

Topic: Heart Failure Treatment and Management
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
The Development of Flipped-Blended Model of Computer Application Course in Higher Education

This study attempts to develop and investigate the effectiveness of flipped-blended model for Computer Application Course. A physical instructional model was developed by researcher and was evaluated by experts and students. The experts reviewed the model and provided input for improving the instructional model. The experts were subject matter experts, instructional design experts, media experts, and language experts. Those experts provided suggestions for improving the instructional model. The experts reviewed instructional analysis, instructional strategies, map of competencies, assessment instruments, and learning materials consisting of worksheets and online videos. The experts have recommended some revision of the map of competencies, the directions on pre-tests and post-tests, the worksheets, and the online videos. After being revised, the model is ready to be tested by students. The trial of the model was conducted by lecturers and students after the revision of the model was completed. A total of 24 students from Muhammadiyah Economics School Jakarta also participated in this study. A single group pretest-posttest design was used. The means of the pretest and posttest were determined to find the effectiveness of the flipped-blended model. The attitude survey questionnaire was used to explore the studentsâ€™ attitude towards the flipped-blended model for Computer Application course and interviews with students were administered to find more information about the studentsâ€™ attitudes and perceptions. A paired sample t-test showed that there was a statistical significant difference in the means of pretest (M = 54.64) and posttest (M = 83.27). They were significantly different by 28.63 with p-value less than alpha level (Î± =.05), indicating an improvement due to the treatment of the instructional model. Interactions in flipped-blended models took place both online and in classroom. The online interactions often occurred on Whatsapp application. According to the students, Whatsapp usage was easier and faster because the messages were received and replied immediately. Meanwhile, interactions in the classroom occured fairly often because the lecturer goes around the class to help students who are in trouble. This happens because the lecture material is presented outside the classroom so that the lecturers and students have more time to complete tasks. Various concepts can be more easily understood by students in the classroom by completing the assigned tasks. The results of the interview shows that students prefer complicated assignments to easy assignments. Students have become accustomed to easy assignments because they have done the easy assignments which were given outside the classroom.

Topic: Innovative Teaching Methods
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Jurisdiction and conflict of laws issues between contracts of transport and insurance

The paper analyses the interaction between the special rules on jurisdiction and conflict of laws applicable to the insurance contract under EU Regulations Brussels Ia and Rome I and the jurisdiction and conflict of laws applicable to contracts of transport under the relevant International Conventions, pointing out how the primary aim of the protection of the insured, as pursued by EU rules, is not fully achieved when the latter rules apply in case of direct action against the liability insurers of the responsible party. Due consideration is given to ECJ recent case law on the issue of co-ordination between the two sets of rules under art. 71 of Brussels Ia Regulation.

Topic: Law, logistics, and international trade
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Electrosteric Enhanced Stability of Functional Sub-10 nm Cerium and Iron Oxide Particles in Cell Culture Medium

Applications of nanoparticles in biology require that the nanoparticles remain stable in solutions containing high concentrations of proteins and salts, as well as in cell culture media. In this work, we developed simple protocols for the coating of sub-10 nm nanoparticles and evaluated the colloidal stability of dispersions in various environments. Ligands (citric acid), oligomers [phosphonate-terminated poly(ethylene oxide)], and polymers [poly(acrylic acid)] were used as nanometer-thick adlayers for cerium (CeO2) and iron (gamma-Fe2O3) oxide nanoparticles. The organic functionalities were adsorbed on the particle surfaces via physical (electrostatic) forces. Stability assays at high ionic strengths and in cell culture media were performed by static and dynamic light scattering. Of the three coatings examined, we found that only poly(acrylic acid) fully preserved the dispersion stability over the long term (longer than weeks). The improved stability was explained by the multipoint attachments of the chains onto the particle surface and by the adlayer-mediated electrosteric interactions. These results suggest that anionically charged polymers represent an effective alternative to conventional coating agents.

Topic: Nanoparticle-Based Drug Delivery
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Evaluation of the Coupled and Coordinated Relationship between Agricultural Modernization and Regional Economic Development under the Rural Revitalization Strategy

Agriculture is one of the three major industries in China, and its level of development occupies an important position in the development of the national economy. At present, China vigorously promotes the strategy of rural revitalization, which provides new opportunities for agricultural modernization. Since modern agriculture and regional economy are coupled in a mutually influencing and constraining relationship, this paper constructs a coupled and coordinated evaluation index system of agricultural modernization and regional economic development. Using the entropy value method and coupled coordination degree model, the comprehensive development level and coordinated development degree of agricultural modernization and regional economic development of 31 provinces, autonomous regions, and cities in China from 2011 to 2020 were evaluated, revealing the time evolution and spatial distribution characteristics of the two systems. The results show that: (1) In the past decade, China’s agricultural modernization and regional economy have made some progress in terms of their respective development levels and the degree of coupling and coordination between them. (2) In terms of spatial evolution, there are obvious regional differences between the two systems, and the coupling coordination degree shows a “ladder” distribution pattern from the east to the central, northeastern, and western parts of the country. (3) Regions with a high level of regional economic development also have a relatively high degree of coupling and coordination between agricultural modernization and regional economic development. Our results provide insights into the economic effects of agricultural modernization in China and provide useful insights into the future direction of agricultural development programs in countries around the world.

Topic: Land Use and Ecosystem Services
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1

Abstract Aberrant expression of long noncoding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) has been detected in human colorectal cancer (CRC). This study aimed to investigate the role of CDKN2B-AS1 and the underlying mechanism in human CRC. Gain- and loss-of-function assays were performed to explore the role of CDKN2B-AS1 in the malignant behavior of HCT116 and SW480 CRC cells in vitro and in vivo. RNA pull-down assay was conducted to identify the target of CDKN2B-AS1 in CRC cells. The physical and functional interactions between CDKN2B-AS1 and the target were examined. CDKN2B-AS1 inhibited CRC cell proliferation and migration while promoting apoptosis in vitro via activation of mitogen-activated protein kinase kinases (MEK)/extracellular signal-regulated kinase (ERK)/p38 signaling. CDKN2B-AS1 bound to mitogen-activated protein kinase (MAPK) inactivator dual-specificity phosphatase 1 (DUSP1) in CRC cells. In contrast to CDKN2B-AS1, DUSP1 promoted CRC cell proliferation, suppressed apoptosis and inactivated MEK/ERK/p38 signaling in CRC cells. Furthermore, CDKN2B-AS1 overexpression attenuated DUSP1 expression in normal colonic myofibroblasts and CRC cells. Overexpression of DUSP1 effectively countered the activation of MEK/ERK/p38 signaling induced by CDKN2B-AS1 overexpression or further blocked MEK/ERK/p38 signaling suppressed by CDKN2B-AS1 silencing. In the mouse xenograft model, CDKN2B-AS1 suppressed CRC growth, whereas DUSP1 promoted CRC growth. CDKN2B-AS1 induced cell apoptosis while suppressing EMT (epithelial–mesenchymal transition), whereas DUSP1 suppressed cell apoptosis while inducing EMT in CRC, as evidenced by the alterations in the protein levels of apoptosis and EMT markers in tumor tissue samples. CDKN2B-AS1 regulates CRC cell growth and survival by targeting MAPK inactivator DUSP1.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Writing Experiment Manuals in Science Education: The impact of writing, genre, and audience

Abstract In this study, Grade 9 students wrote experiment manuals for their peers describing a simple physics investigation to explore whether air takes space. Peers executed these manuals and their processes were videotaped. In several experimental conditions, these videotapes were played back for authors. Then they had to rewrite the experiment manual. Three weeks later they wrote a letter‐of‐advice, explaining to peers how to write an experiment manual. Both measures (rewritten manuals and letter‐of‐advice) showed clear effects of the condition in which writers saw real‐time readers' feedback on their own manual, on understanding of the genre of an experiment manual, as well as on the understanding of physics topics introduced. Acknowledgements This article is based on a paper presented by the first two authors at the international conference on Ontological, Epistemological, Linguistic and Pedagogical Considerations of Language and Science Literacy: Empowering Research and Informing Instruction, Victoria, B.C., Canada, 12–15 September. The authors thank the organizers for the opportunity to leave their research discipline—effective teaching of language and literature—and to mingle in all sorts of literacy and hard sciences. They learnt that terms and concepts ("explaining") in different sciences have different connotations. Happily, Brian Hand (USA) and Larry Yore (Canada) guided us with their comments on previous drafts on our way to embed the literacy jargon into the world of the science educators. Shari Yore's meticulous editing practice taught us much about how to formulate crisp and clear text. The authors also wish to thank David Galbraith (Staffordshire, UK) for his inspiring discussions on writing and learning. Parts of this paper rely on the authors' collaborative work.

Topic: Science Education and Pedagogy
Subfield: Education
Field: Social Sciences
Domain: Social Sciences