jimnoneill/paper-to-field-training huggingface dataset:
A NEW LABORATORY COLONIZATION OF AEDES AEGYPTI AFTER REEMERGENCE AND UNSUCCESSFUL ERADICATION IN ST. AUGUSTINE, FLORIDA

After unsuccessful eradication attempts against Aedes aegypti (L.) following a sudden re-emergence in St. Augustine, Florida in early 2016; a new locally acquired colony strain of Ae. aegypti was established at the Anastasia Mosquito Control District (AMCD) in June 2017. Aedes aegypti adults were maintained in cages at the AMCD insectary. Larval and adult mosquitoes were collected from downtown St. Augustine, Florida. Female mosquitoes at 5-7 days old were fed upon the exposed forearm of human volunteers in the 1 st and 2 nd generations. Mating was observed in a large cage and confirmed with eggs deposited on wet filter paper in ovicups. Over 90% egg hatch was observed in the laboratory. The new colony strain of Ae. aegypti has been cataloged at the USDA, Center for Medical, Agricultural, and Veterinary Entomology facility in Gainesville, FL and is being used to further research and control this species across North Florida.

Topic: Mosquito-borne diseases and control
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events

Given the broad implementation of immune checkpoint inhibitors (ICI) for cancer therapy, we encounter a variety of immune-related adverse events (irAE) including immune-related blood eosinophilia. Eosinophilia demonstrated a potential positive predictive marker for a beneficial clinical response to ICI. However, there are reports of eosinophil-induced adverse events (Eo-irAE) with organ dysfunction requiring initiation of oral glucocorticoid therapy and discontinuation of ICI. We aim to assess the efficacy and safety of interleukin (IL) 5-axis inhibition in Eo-irAE secondary to ICI therapy. We present three cases of Eo-irAE referred to our allergy and clinical immunology unit at Hadassah Hebrew University Medical Center following therapy with pembrolizumab and nivolumab, monoclonal antibodies that target the programmed cell death 1 (PD-1) receptor, for two cases of melanoma and one metastatic non-small cell lung carcinoma. Following informed consent and committee approval, two patients were treated with 1–3 doses of mepolizumab, 100 mg, monoclonal IgG1 kappa anti-IL-5 antibody, and one patient received up-to-date 9 doses of benralizumab, 30 mg, monoclonal IgG1 kappa antibody directed against the alpha chain of the interleukin-5 receptor, both administered subcutaneously. Patients were carefully followed and treatment response was assessed by physical examinations and laboratory tests. Hypereosinophilia at the level of 2300–8000 K/UL was observed 8–12 months following therapy accompanied by symptoms of dyspnea, arthralgia, myalgia, fasciitis, ‘morphea’-like lesions, fatigue, abdominal discomfort, pruritus, and chest pain. ICI discontinuation did not improve symptoms, two patients were resistant to glucocorticoids and therefore biological treatment was initiated to inhibit the IL5 axis. Patients demonstrated rapid clinical response and a decrease in peripheral blood eosinophil levels with long-term symptoms remission. There were no signals of negative impacts, such as tumor progression following IL5 axis inhibition. Eosinophilia secondary to ICI therapy can lead to organ dysfunction. Discontinuation of ICI might not be effective and symptoms may be refractory to steroid therapy hence targeted inhibition of the IL5 axis should be considered.

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
R.D.S.: NeuroPhone: Brain-Mobile Phone Interface using a Wireless EEG Headset

Neural signals are everywhere just like mobile phones. We propose to use neural signals to control mobile phones for hands-free, silent and effortless human-mobile interaction. Until recently, devices for detecting neural signals have been costly, bulky and fragile. We present the design, implementation and evaluation of the NeuroPhone system, which allows neural signals to drive mobile phone applications on the iPhone using cheap off-the-shelf wireless electroencephalography (EEG) headsets. We demonstrate a brain-controlled address book dialing app, which works on similar principles to P300-speller brain-computer interfaces: the phone flashes a sequence of photos of contacts from the address book and a P300 brain potential is elicited when the flashed photo matches the person whom the user wishes to dial. EEG signals from the headset are transmitted wirelessly to an iPhone, which natively runs a lightweight classifier to discriminate P300 signals from noise. When a person’s contactphoto triggers a P300, his/her phone number is automatically dialed. NeuroPhone breaks new ground as a brainmobile phone interface for ubiquitous pervasive computing. We discuss the challenges in making our initial prototype more practical, robust, and reliable as part of our on-going research. Categories and Subject Descriptors

Topic: EEG and Brain-Computer Interfaces
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
An ontological approach to identify the causes of hazards for safety-critical systems

Preliminary hazard analysis (PHA) is a key safety-concerned technique, applied in early stages of safety critical systems development, aiming to provide stakeholders with a general understanding of potential hazards together with their causes. Various studies have asserted that most significant flaws in hazard analysis techniques are related to the omission of causes associated with the identified hazards. In addition, identified causes are sometimes described in too generic terms to provide useful guidance for subsequent activities. In this paper, we propose an approach to explore and identify the causes associated with the hazards from a PHA, aiming to improve the results of hazard causes identification in terms of completeness and usefulness. To achieve the goal, the proposed approach utilizes the hazard-related concepts and relations defined in a hazard domain ontology presented in our previous work [1]. Furthermore, an application scenario of a train control system is used to evaluate our approach.

Topic: Risk and Safety Analysis
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Omental pedicle flaps following proctectomy: a systematic review

Abstract Aim Abdominoperineal excision ( APR ) for cancer carries significant morbidity of the perineal wound. An omental pedicle graft has been used to fill the pelvis and limit attendant complications after radical extirpation of the anorectum. A review of the literature was conducted to determine whether omentoplasty following APR reduces perineal wound complications. Method Three major databases (PubMed, MEDLINE and the Cochrane Library) were searched. The review included original articles reporting outcomes after APR and omentoplasty from January 1950 to July 2012. Results Fourteen studies involving 891 patients (mean age 61 years, 59.8% men) were included. Median follow‐up was 13.5 months. A variety of omentoplasty techniques added a median of 20 min to the operating time. The mean rate of primary wound healing was 66.8%, time to wound healing 24 days and weighted mean wound infection rate 14.4% with omentoplasty compared with 50.1%, 79 days and 18.5% in patients having no omentoplasty. Conclusion Omental mobilization, transfer and buttressing of primary perineal repair following proctectomy reduces perineal wound morbidity with minimal additional operating time or flap‐associated morbidity.

Topic: Anorectal Disease Treatments and Outcomes
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
The Effect of Website Quality and Brand Image on Consumer Purchase Decisions with Trust as an Intervening Variable (Case Study at Bukalapak.com)

This study aims to analyze the effect of Website Quality and Brand Image on Consumer Purchase Decision with Trust as Intervening Variable (Case Study on Bukalapak.com). The object of research used is Bukalapak.Com customer as many as 100 respondents. While the determination of the sample using purposive random sampling technique. The analytical technique used is Structural Equation Modeling (SEM). The result of analysis in this research shows that (1) website quality has positif and significant effect on purchasing decision, (2) Brand Image has positif and significant effect on purchase decision, (3) Trust has a positif and significant effect on purchase decision, (4) website quality has positif and significant effect on trust, and (5) Brand image has positif and significant effect on trust. Keywords : E-Commerce, website quality, brand image, trust, purchase decision. DOI : 10.7176/EJBM/11-28-09 Publication date :October 31 st 2019

Topic: Consumer Behavior and Marketing Influence
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
Ion−Solvent Interactions in Acetonitrile Solutions of Lithium, Sodium, and Tetraethylammonium Perchlorate Using Attenuated Total Reflectance FTIR Spectroscopy

A vibrational spectroscopic study of ion solvation in LiClO4−, NaClO4−, and tetraethylammonium perchlorate−acetonitrile solutions has been performed using attenuated total reflection FTIR spectroscopy. Spectra were curve fitted in the C⋮N stretching and C−C⋮N bending regions of the solvent using a multiple-dimensional fitting routine that factors an entire set of solution spectra into their physically real basis spectra according to a user supplied mathematical model. The spectra of the solutions of tetraethylammonium perchlorate in acetonitrile were shown to be a linear combination of one physically real basis spectrum that accounts for self-associated acetonitrile and another that accounts for the spectrum of the acetonitrile molecules associated with the perchlorate anion. It is demonstrated for the first time that the C⋮N stretching band of acetonitrile molecules associated with ClO4- anions has a significantly different molar absorption coefficient from the same band for self-associated acetonitrile. The spectra of LiClO4 and NaClO4 solutions in acetonitrile were shown to be a linear combination of one physically real basis spectrum that accounts for the spectrum of self-associated acetonitrile and another that accounts for the spectrum of the acetonitrile molecules associated with both the cation and the anion. The fractional contribution of these physically real basis spectra to the solution spectra depends on the total electrolyte concentration, rather than on the extent of ion pairing. Two possible rationalizations for this phenomenon are discussed.

Topic: Analytical Chemistry and Chromatography
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Online Checkpointing with Improved Worst-Case Guarantees

In the online checkpointing problem, the task is to continuously maintain a set of k checkpoints that allow to rewind an ongoing computation faster than by a full restart. The only operation allowed is to replace an old checkpoint by the current state. Our aim are checkpoint placement strategies that minimize rewinding cost, i.e., such that at all times T when requested to rewind to some time t &lt;= T the number of computation steps that need to be redone to get to t from a checkpoint before t is as small as possible. In particular, we want that the closest checkpoint earlier than t is not further away from t than q_k times the ideal distance T / (k+1), where q_k is a small constant. Improving over earlier work showing 1 + 1/k &lt;= q_k &lt;= 2, we show that q_k can be chosen asymptotically less than 2. We present algorithms with asymptotic discrepancy q_k &lt;= 1.59 + o(1) valid for all k and q_k &lt;= ln(4) + o(1) &lt;= 1.39 + o(1) valid for k being a power of two. Experiments indicate the uniform bound p_k &lt;= 1.7 for all k. For small k, we show how to use a linear programming approach to compute good checkpointing algorithms. This gives discrepancies of less than 1.55 for all k &lt; 60. We prove the first lower bound that is asymptotically more than one, namely q_k &gt;= 1.30 - o(1). We also show that optimal algorithms (yielding the infimum discrepancy) exist for all k.

Topic: Distributed systems and fault tolerance
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Research Guides: Exam Jam: What is Examageddon

Finals are coming... are you ready? Join the SLRC in study sessions, activities, foods, coaching, and more to get you ready for finals. Find out more about how to get tutored and win prizes! We also have information on the great study breaks the SLRC is offering this year, including our ever popular therapy dogs!

Topic: Educational Games and Gamification
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Slow growth of the Rayleigh-Plateau instability in aqueous two phase systems

This paper studies the Rayleigh-Plateau instability for co-flowing immiscible aqueous polymer solutions in a microfluidic channel. Careful vibration-free experiments with controlled actuation of the flow allowed direct measurement of the growth rate of this instability. Experiments for the well-known aqueous two phase system (ATPS, or aqueous biphasic systems) of dextran and polyethylene glycol solutions exhibited a growth rate of 1 s−1, which was more than an order of magnitude slower than an analogous experiment with two immiscible Newtonian fluids with viscosities and interfacial tension that closely matched the ATPS experiment. Viscoelastic effects and adhesion to the walls were ruled out as explanations for the observed behavior. The results are remarkable because all current theory suggests that such dilute polymer solutions should break up faster, not slower, than the analogous Newtonian case. Microfluidic uses of aqueous two phase systems include separation of labile biomolecules but have hitherto be limited because of the difficulty in making droplets. The results of this work teach how to design devices for biological microfluidic ATPS platforms.

Topic: Innovative Microfluidic and Catalytic Techniques Innovation
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Agent Based Model for Resource Constrained Scheduling of Construction Projects

This paper presents an Agent Based Model (ABM) for resource constrained scheduling of construction projects. The model considers typical scheduling characteristics such as the four precedence relationships. It also allows for activities to be interrupted, if needed. Moreover, the model considers the impact of the finish quality of a given activity on its successors. An illustrative example was presented to demonstrate the performance of the proposed model. Overall, the model was successful in minimizing project durations by utilizing different priority rules. ABM concepts were proved to be applicable in resource constrained scheduling. The model provided added versatility to activity characteristics.

Topic: Resource-Constrained Project Scheduling
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
Family Involvement in the Firm, Family-to-Business Support, and Entrepreneurial Outcomes: An Exploration

Results of a survey of 211 founders of small and medium‐sized enterprises (SMEs) indicated that family involvement in the firm was indirectly related to four entrepreneurial outcomes (business performance, strategic planning, satisfaction with business success, and commitment to remain self‐employed) through family‐to‐business support, suggesting a particular benefit of the intertwining of family and business in family firms. SME founders who owned family firms experienced higher levels of family‐to‐business support than those who owned nonfamily firms. These results support our proposed alignment of the social support perspective of well‐being and resiliency with the family embeddedness perspective of the family‐business relationship.

Topic: Family Business Performance and Succession
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Calibration of Discrete Element Parameters of Maize Root and Its Mixture with Soil

Discrete element simulation is an effective method to reveal the interaction between tillage components and work objects. However, due to the lack of discrete element modelling parameters of maize root and its mixture with soil, existing tillage models cannot accurately simulate the farmland environment under a no-tillage system. This study developed single maize root (SMR) with different diameters and maize root-soil mixture (MRSM) DEM models based on calibrated parameters through the angle of repose (AOR) tests. First, the Plackett–Burman and the steepest climb tests were performed to identify the range of essential parameters for the AOR of the SMR. Then, the optimal parameters for the SMR and MRSR models were obtained by Box–Behnken design (BBD) testing. The results showed that the static friction coefficient of SMR-SMR and the rolling friction coefficient of SMR-SMR and SMR-steel significantly affected the AOR. In addition, the AOR of MRSM was extremely sensitive to the restitution coefficient and surface energy coefficient of root soil. Based on optimal parameters, the relative errors between the simulated and measured AOR and pixel peak values of the piles’ contour curve were less than 5% for SMR and MRSM. The error of the dynamic AOR of the measured and simulated MSRM was less than 10%. These results indicate that the parameter calibration method and the developed models can be valuable references for DEM simulation for maize stubble and tillage.

Topic: Soil Mechanics and Vehicle Dynamics
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
Passive transdermal drug delivery systems: Recent considerations and advances

The skin has evolved as a formidable barrier against invasion by external microorganisms and against the prevention of water loss. Notwithstanding this, transdermal drug delivery systems have been designed with the aim of providing continuous controlled delivery of drugs via this barrier to the systemic circulation. There are numerous systems now available that effectively deliver drugs across the skin. These include reservoir devices, matrix diffusion-controlled devices, multiple polymer devices, and multilayer matrix systems. This review article focuses on the design characteristics and composition of the main categories of passive transdermal delivery device available. Mechanisms controlling release of the active drug from these systems as well as patch size and irritation problems will be considered. Recent developments in the field are highlighted including advances in patch design as well as the increasing number of drug molecules now amenable to delivery via this route. From the early complex patch designs, devices have now evolved towards simpler, matrix formulations. One of the newer technologies to emerge is the delivery-optimized thermodynamic (DOT) patch system, which allows greater drug loading to be achieved in a much smaller patch size. With the DOT technology, drug is loaded in an acrylic-based adhesive. The drug/acrylic blend is dispersed through silicone adhesive, creating a semi-solid suspension. This overcomes the problem with conventional drug-in-adhesive matrix patches, in which a large drug load in the adhesive reservoir can compromise the adhesive properties or necessitate a large patch size. Transdermal drug delivery remains an attractive and evolving field offering many benefits over alternative routes of drug delivery. Future developments in the field should address problems relating to irritancy and sensitization, which currently exclude a number of therapeutic entities from delivery via this route. It is likely that further innovations in matrix composition and formulation will further expand the number of candidate drugs available for transdermal delivery. © 2006 Adis Data Information BV. All rights reserved.

Topic: Advancements in Transdermal Drug Delivery
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Impact of processing conditions and gelling agent on physical and sensorial properties of pecan oil-dulce de leche gummy candies

Abstract For the development of gelatinized dairy products that include emulsified pecan oil as an unsaturated fatty acid source the incorporation of hydrocolloids becomes necessary and their properties must be carefully selected. This work aimed to study gelatinized candies made with 0% milk fat dulce de leche with pre-emulsified pecan nut oil using combinations of gelatin (4.67 to 7 g/100 g) and high methoxyl pectin (1.33 to 2 g/100 g) as gelling agents. The effect of different drying methods (vacuum-oven at 35 °C for 24 h and freeze-drying) was evaluated. Control samples without drying were also studied. Dehydration conditions significantly (p &lt; 0.05) affected aw, texture (hardness, cohesiveness, adhesiveness, gumminess, springiness, and resilience) and color parameters (L*, a*, b*) of products, being higher than the effect of the gelling agent. Formulations were selected based on texture and aw criteria and sensory evaluated by appearance, color, texture, taste, and overall acceptability. Two formulations (one with 7% gelatin and 1.33% high methoxyl pectin content, and the other with 2% high methoxyl pectin and 4.67% gelatin content), both with low moisture content and vacuum-dried, exhibited good acceptability. These pecan oil-dulce de leche gummy candies would represent a healthier candy version, low in saturated fatty acids, and source of oleic acid.

Topic: Nuts composition and effects
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Three-Dimensional Printing in Cleft Care: A Systematic Review

Objective: To determine the current applications of 3-dimensional (3D) printing in the care of patients with cleft lip and palate. We also reviewed 3D printing limitations, financial analysis, and future implications. Design: Retrospective systematic review. Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were used by 3 independent reviewers. Articles were identified from Cochrane library, Ovid Medline, and Embase. Search terms included 3D printing, 3 dimensional printing, additive manufacturing, rapid prototyping, cleft lip, and cleft palate. Exclusion criteria included articles not in English, animal studies, reviews without original data, oral presentations, abstracts, opinion pieces, and articles without relevance to 3D printing or cleft lip and palate. Main Outcome Measures: Primary outcome measure was the purpose of 3D printing in the care of patients with cleft lip and palate. Secondary outcome measures were cost analysis and clinical outcomes. Results: Eight-four articles were identified, and 39 met inclusion/exclusion criteria. Eleven studies used 3D printing models for nasoalveolar molding. Patient-specific implants were developed via 3D printing in 6 articles. Surgical planning was conducted via 3D printing in 8 studies. Eight articles utilized 3D printing for anatomic models/educational purposes. 3-Dimensional printed models were used for surgical simulation/training in 6 articles. Bioprinting was utilized in 4 studies. Secondary outcome of cost was addressed in 8 articles. Conclusion: 3-Dimensional printing for the care of patients with cleft lip and palate has several applications. Potential advantages of utilizing this technology are demonstrated; however, literature is largely descriptive in nature with few clinical outcome measures. Future direction should be aimed at standardized reporting to include clinical outcomes, cost, material, printing method, and results.

Topic: Anatomy and Medical Technology
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences