jimnoneill/paper-to-field-training huggingface dataset:
Investigating the Panax ginseng proteome using an in silico method to find bioactive peptides that can alter the dynamics of breast cancer carcinogenesis

Breast cancer is a major public health concern throughout the world, particularly in Cameroon. Numerous modalities, including surgery, radiotherapy, and chemotherapy, have been used for clinical cancer therapy. Despite advances in anti-cancer therapies, the use of these methods to treat cancer is often associated with deleterious side effects and multi-drug resistance to conventional anti-cancer drugs, which has led to the development of new therapeutic methods, anti-cancer peptides (ACP). The aim of this study was to produce peptides that could be potential modulators of breast cancer, using in silico prediction as complementary tool. Several techniques were applied to achieve this goal: Protein hydrolysis, protein-peptide molecular docking, and target prediction have all been employed as techniques. It has been determined that 156 genes may play a role in the carcinogenesis of breast cancer. Ten (10) kinases (CDK1, NLK, CDK4, CDK2, CSNK2A1, GSK3B, HIPK2, MAPK14, CK2ALPHA, and MAPK1) and 10 transcription factors (TRIM28, CHD1, SOX2, NANOG, UBTF, TCF7L2, TCF3, CTCF, SUZ12, and NFE2L2) were identified as involved in the process of breast cancer carcinogenisis. Only nineteen of the 1324 peptides that were synthesised exhibited an affinity of greater than 20%, and approximately twenty-eight distinct proteins were found. The peptides AIF, AIN, APQVAVL, ESK, IAK, PSIPK, PVGF, and SDTEL are all intriguing candidates for additional research, according to the overall findings. The study's non-allergic peptides had binding energy values of less than or equal to -5.00 kcal.mol. Future studies will use both in vitro and in vivo methods to examine the positive effects of hydrolyzed peptides.

Topic: Ginseng Biological Effects and Applications
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Global Evolutionary Algorithms in the Design of Electromagnetic Band Gap Structures with Suppressed Surface Waves Propagation

The paper is focused on the automated design and optimization of electromagnetic band gap structures suppressing the propagation of surface waves. For the optimization, we use different global evolutionary algorithms like the genetic algorithm with the single-point crossover (GAs) and the multi-point (GAm) one, the differential evolution (DE) and particle swarm optimization (PSO). The algorithms are mutually compared in terms of convergence velocity and accuracy. The developed technique is universal (applicable for any unit cell geometry). The method is based on the dispersion diagram calculation in CST Microwave Studio (CST MWS) and optimization in Matlab. A design example of a mushroom structure with simultaneous electromagnetic band gap properties (EBG) and the artificial magnetic conductor ones (AMC) in the required frequency band is presented.

Topic: Advanced Antenna and Metasurface Technologies
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Accelerated internationalisation: evidence from a late investor country

Purpose Recent studies are trying to adapt the explanation of the internationalisation process to new environmental conditions. This paper aims to offer evidence of the existence of a group of firms that use a speeded‐up internationalisation process. Design/methodology/approach Cluster analysis and logit regressions are used on a sample of 271 Spanish export firms. Findings The results obtained support the claim that substantial differences do exist between fast and gradual internationalising firms. The firms included in the more international active group are characterised by: a proactive attitude on the part of managers with regard to internationalisation activities, a strategy based on marketing differentiation advantages and strong relationships with clients and suppliers, which encourage or facilitate their international activities. Practical implications The results may favour reflection upon what are the most important factors for achieving an active, international strategy and how to respond to these demands. The stimulation of relationships between firms will reduce the uncertainty associated with the risks of foreign operations and increase the international competitiveness of firms. Originality/value From a politics perspective the research suggests several ways to stimulate the acceleration of the internationalisation process.

Topic: International Business and FDI
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Supplementary Figure S14 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway

&lt;p&gt;LNS8801 does not inhibit AML in systemic in vivo model (A) Proliferation assay of luciferase-expressing MV4-11 (MV4-11-Luc) cells. Cells were incubated for 72 hours and were counted with trypan blue dye. 5 replicates were used for experiment. P-values were calculated via pairwise t-tests (*p=&lt;0.05, **p=&lt;0.01, ***p=&lt;0.001, ****p=&lt;0.0001). (B) Systemic in vivo experiment done with MV4-11-Luc. Male NSG mice were used for the experiment. Mice were treated with vehicle or LNS8801 daily through oral gavage. 3 animals were used per condition.&lt;/p&gt;

Topic: S100 Proteins and Annexins
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The contribution of the banking system to achieving economic growth – Econometric study (1962-2016)

Several economic studies have shown that the banking system has a positive effect on economic development, through its ability to transfer a large mass of savings resources to the productive investment needs of the private sector. This work has a purpose to study these demonstrations in the case of Algerian banks and its role in development. To arrive at the final result, we used an econometric method that helped us to study the impact of banking variables on economic growth - as an indicator of economic development - in Algeria during the period 1962-2016. We have found qs result of this work, that banking variables have a negative effect on economic growth, especially the credit variable, so for this, the banking role in Algeria is still far from achieving economic development.

Topic: Islamic Finance and Banking Studies
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
Numerical Study for Interaction Between Water Mist and Counterflow Diffusion Flame Over Tsuji Burner

Abstract The interaction between a water mist and a counterflow diffusion flame over a Tsuji burner is studied numerically. The governing system is comprised of two parts. The gas phase combustion model adopts the one developed by Chen and Weng (1990). For droplets, their motions are described by Newton's second law. The corresponding droplet heat and mass transfer are considered by using empirical correlations. The PSI-Cell model is used to manage the two-phase coupling. The evaporation of droplets through heat absorption from the flame can generate vapor in the flow field. The vapor dilutes both the oxidizer and fuel concentrations, and the heat absorption by phase change lowers the flame temperature. For 50 p.m droplets, the envelope flame is extinguished from the forward stagnation area and becomes a wake flame as the mist flow rate increases to 7%. The wake flame no longer exists when the mist flow rate is greater than 15%. The critical values for transition of the envelope flame to a wake flame and complete flame extinction for 80 μn droplets were 4·5% and 10% separately. Under the same mist flow rate, the smaller the droplet sizes, the stronger the flame. The effect of droplet size is studied by changing the droplet size and the corresponding mist flows with the number flow rate constant. The critical sizes for transition of the envelope flame to a wake flame and for complete flame extinction were 55 μm and 75 μm respectively. Future work is also discussed. Additional informationNotes on contributorsCHIUN-HSUN CHEN Corresponding author: E-mail: chchen@cc.nctu.edu.tw. Tel.: 886-3-5712121. Ext. 55130. Fax: 886-3-5721091

Topic: Combustion and flame dynamics
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Dynamics of the Ising Chain with Four-Spin Interactions in a Disordered Transverse Magnetic Field

We study the time dependent behavior of the four-spin interactions Ising chain in the presence of a disordered transverse magnetic field. In order to analyze the effects of field randomness in the dynamical behavior of the system we calculate the time-dependent correlation function and the longitudinal relaxation function of the infinite chain. We consider a bi-modal distribution for the field energy strength, where one of its values equals the exchange coupling energy while the other value can be lower or higher than the coupling energy. We find that an increasing concentration of weaker fields produces an enhancement of the central mode behavior. However, when the concentration of stronger fields increases, the system undergoes a crossover from central mode to collective-type dynamics.

Topic: Theoretical and Computational Physics
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
A Domain Specific Modeling Approach for Coordinating User-Centric Communication Services

Rapid advances in electronic communication devices and technologies have resulted in a shift in the way communication applications are being developed. These new development strategies provide abstract views of the underlying communication technologies and lead to the so-called user-centric communication applications. One user-centric communication (UCC) initiative is the Communication Virtual Machine (CVM) technology, which uses the Communication Modeling Language (CML) for modeling communication services and the CVM for realizing these services. In communication-intensive domains such as telemedicine and disaster management, there is an increasing need for user-centric communication applications that are domain-specific and that support the dynamic coordination of communication services commonly found in collaborative communication scenarios. However, UCC approaches like the CVM offer little support for the dynamic coordination of communication services resulting from inherent dependencies between individual steps of a collaboration task. Users either have to manually coordinate communication services, or reply on a process modeling technique to build customized solutions for services in a specific domain that are usually costly, rigidly defined and technology specific.

Topic: Service-Oriented Architecture and Web Services
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Two lethal chondrodysplasias with giant chondrocytes

Abstract Two infants, each with a different form of sporadic lethal chondrodysplasia, had multinucleated giant chondrocytes in resting cartilage. Both patients also had severe laryngeal stenosis and normal chromosomes. The radiographic abnormalities in one patient conformed to the recently delineated entity, atelosteogenesis (spondylohumerofemoral hypoplasia or giant cell chondrodysplasia); the other patient had an unclassified type of spondyloepiphyseal dysplasia. The findings in these two patients and the previously reported observations in spondylohumerofemoral dysplasia confirm that chondrocytic giant cells are a causally nonspecific phenomenon.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Theophylline Pharmacokinetics in Spinal Cord Injury: A Preliminary Report

"Theophylline Pharmacokinetics in Spinal Cord Injury: A Preliminary Report." The Journal of The American Paraplegia Society, 8(2), pp. 23–24

Topic: Spinal Cord Injury Research
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Testing for unit roots in panels in the presence of structural change with an application to OECD unemployment

There has been extensive research on testing for unit roots in the presence of structural change and on testing for unit roots in panels. This chapter takes a small step towards combining the two research agendas.We propose a unit root test for non-trending data in the presence of a one-time change in the mean for a heterogeneous panel.The date of the break is determined endogenously.We perform simulations to investigate the power of the test,and apply the test to a data set of annual unemployment rates for 17 OECD countries from 1955 to 1990.

Topic: Monetary Policy and Economic Impact
Subfield: General Economics, Econometrics and Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
416 Esophageal Body Dysfunction in Patients With Esophagogastric Junction Outflow Obstruction: A Potential Flaw in the Chicago Classification

INTRODUCTION: High-resolution manometry using the Chicago Classification is standard in the evaluation of esophageal motility. When the relaxation of the esophagogastric junction is impaired and achalasia excluded, esophagogastric junction outflow obstruction (EGJ-OO) is diagnosed and the esophageal body is essentially ignored. We sought to characterize the function of the esophageal body in consecutive patients with EGJ-OO. METHODS: Retrospective review of the esophageal manometry findings in consecutive patients where there was computer recognition of EGJ-OO collected over a 2-month period. In each case, the esophageal body was reviewed manually and results reported independent of the suggested computer diagnosis. RESULTS: 116 patients underwent manometry over a 2-month period and 30 (26%) were identified as having EGJ-OO. The indications for testing included chronic cough (n = 5), GERD (n = 8), dysphagia (n = 9) and esophageal evaluation associated with severe lung disease or transplantation (n = 8). The mean IRP was 20.8 (range 16-33.6) and did not vary depending on indication ( P = 0.381). Computer interpretation was EGJ-OO in all patients without mention of the esophageal body. After review, 11 (37%) had an additional esophageal diagnosis. In effective esophageal motility (IEM) was the most prevalent among them (IEM-8, achalasia-2, jackhammer esophagus-1; P = 0.020). The frequency of an additional esophageal diagnosis was significantly different between GERD (0%) and dysphagia (66%; P = 0.004), but not between other groups (i.e. 40% in cough and 37.5% in transplant group). An esophageal body diagnosis was significantly more likely in patients with IRP &gt; 25 (80%) compared with those with IRP &lt; 25 (28%; P = 0.028). CONCLUSION: 1-EGJ-OO is common in patients referred for esophageal manometry. 2-An additional esophageal body diagnosis is common in those with EGJ-OO.3-Esophageal diagnoses are more common in patients with dysphagia and in those with a very high IRP. The body of the esophagus is important in cases of EGJ-OO and should be reported independent of the computer-generated interpretation of the Chicago Classification.

Topic: Gastroesophageal reflux and treatments
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Automatic accuracy management of quantum programs via (near-)symbolic resource estimation.

When compiling programs for fault-tolerant quantum computers, approximation errors must be taken into account. We propose a methodology that tracks such errors automatically and solves the optimization problem of finding accuracy parameters that guarantee a specified overall accuracy while aiming to minimize a custom implementation cost. The core idea is to extract constraint and cost functions directly from the high-level description of the quantum program. Then, our custom compiler passes optimize these functions, turning them into (near-)symbolic expressions for (1) the total error and (2) the implementation cost (e.g., total gate count). All unspecified parameters of the quantum program will show up as variables in these expressions, including accuracy parameters. After solving the corresponding optimization problem, a circuit can be instantiated from the found solution. We develop two prototype implementations, one in C++ based on Clang/LLVM, and another using the Q# compiler infrastructure. We benchmark our prototypes on typical quantum computing programs, including the quantum Fourier transform, quantum phase estimation, and Shor's algorithm.

Topic: Quantum Computing Algorithms and Architecture
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Absolute free energy of solvation from Monte Carlo simulations using combined quantum and molecular mechanical potentials

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbsolute free energy of solvation from Monte Carlo simulations using combined quantum and molecular mechanical potentialsJiali GaoCite this: J. Phys. Chem. 1992, 96, 2, 537–540Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/j100181a009https://doi.org/10.1021/j100181a009research-articleACS PublicationsRequest reuse permissionsArticle Views542Altmetric-Citations180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

Topic: Spectroscopy and Quantum Chemical Studies
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Do Workers Value Flexible Jobs? A Field Experiment

We explore workers’ valuation of job flexibility using a field experiment conducted on a Chinese job board. Our experimental job ads differ randomly in offering jobs that are flexible regarding when (time flexibility) or where (place flexibility) one works and in offering different salaries. Application rates are higher for flexible jobs conditional on the salary offered, providing evidence that workers value job flexibility. Moreover, under some plausible conditions our evidence is informative about job seekers’ willingness to pay for flexible jobs of the types offered in the experiment and points to fairly high valuation of the most flexible jobs.

Topic: Experimental Behavioral Economics Studies
Subfield: Safety Research
Field: Social Sciences
Domain: Social Sciences
A system to provide sub-milliKelvin temperature control at T~300K for extreme precision optical radial velocimetry

We present preliminary results for the environmental control system from NEID, our instrument concept for NASA's Extreme Precision Doppler Spectrograph, which is now in development. Exquisite temperature control is a requirement for Doppler spectrographs, as small temperature shifts induce systematic Doppler shifts far exceeding the instrumental specifications. Our system is adapted from that of the Habitable Zone Planet Finder instrument, which operates at a temperature of 180K.We discuss system modifications for operation at T ~ 300K, and show data demonstrating sub-mK stability over two weeks from a full-scale system test.

Topic: Stellar, planetary, and galactic studies
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Metal Oxide Anode Materials for Lithium-Ion Batteries

Lithium-ion batteries have become the most popular power source for portable electronics, offering very good energy density, along with favorable stability and efficiency [1]. At the Li-ion anode, graphitic carbons have been ubiquitous [2], though these materials may lack sufficient energy density to enable grid or home-scale energy storage or the realization of fully electric vehicles with sufficient driving range. Therefore, recent years have seen a shift in focus to the development of materials with higher capacity than graphite. Metal oxides are a promising family of materials that could potentially replace graphite as the anode in lithium-ion batteries. Metal oxides typically do not intercalate lithium during charging process, but rely on chemical transformations with more than one electron transfer to store and deliver energy, which results in much higher capacities. In addition, they also have a safer lithiation potential that eliminates the problematic lithium plating process during charging. However, the use of metal oxides has been limited mainly by their low electrical conductivity, and inferior cycling stability [3-5]. To circumvent these challenges, nanostructured metal oxides and their composites with advanced carbon materials, such as graphene, can be used to improve their capacity retention by suppressing phase segregation during charge/discharge and volumetric expansion, as well as enhancing ionic and electronic transport. In this work, the interaction between metal oxides (Co 3 O 4 , SnO 2 , NiO, MnO 2 ) and several carbon substrates was explored using a combination of electrochemical and physical characterization. Increased interfacial interaction between carbon and metal oxide, while minimizing the carbon loading, is critical to improve battery performance. Excellent capacity retention and rate capability can be realized through a combination of material chemistry and structure, and promising approaches to achieve this will be the focus of this presentation. [1] Tarascon. J, Armand. M, Nature , 414 (2001) 359. [2] Sawai. K, Ohzuku. T, J. Electrochem. Soc., 150 (2003) A674. [3] Lee, S. H.; Kim, Y. H.; Deshpande, R.; Parilla, P. A.; Whitney, E.; Gillaspie, D. T.; Jones, K. M.; Mahan, A. H.; Zhang, S. B.; Dillon, A. C., Adv. Mater., 20 (2008) 3627. [4] N.S. Spinner, A. Palmieri, N. Beauregard, L. Zhang, J. Campanella and W.E. Mustain, J. Power Sources , Accepted. [5] N. Spinner, L. Zhang and W.E. Mustain, J. Mat. Chem. A , 2(6) (2014) 1627-1630.

Topic: Advancements in Battery Materials
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences