jimnoneill/paper-to-field-training huggingface dataset:
Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA primeâprotein boost HIV-1 vaccine in healthy human volunteers

An optimally effective AIDS vaccine would likely require the induction of both neutralizing antibody and cell-mediated immune responses, which has proven difficult to obtain in previous clinical trials. Here we report on the induction of human immunodeficiency virus type-1 (HIV-1)-specific immune responses in healthy adult volunteers that received the multi-gene, polyvalent, DNA primeâprotein boost HIV-1 vaccine formulation, DP6-001, in a Phase I clinical trial. Robust cross-subtype HIV-1-specific T cell responses were detected in IFN-Î³ ELISPOT assays. Furthermore, we detected high titer serum antibody responses that recognized a wide range of primary HIV-1 Env antigens and also neutralized pseudotyped viruses that express the primary Env antigens from multiple HIV-1 subtypes. These findings demonstrate that the DNA primeâprotein boost approach is an effective immunization method to elicit both humoral and cell-mediated immune responses in humans, and that a polyvalent Env formulation could generate broad immune responses against HIV-1 viruses with diverse genetic backgrounds.

Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Vertebrate Somitogenesis

▪ Abstract In vertebrates, the paraxial mesoderm corresponds to the bilateral strips of mesodermal tissue flanking the notochord and neural tube and which are delimited laterally by the intermediate mesoderm and the lateral plate. The paraxial mesoderm comprises the head or cephalic mesoderm anteriorly and the somitic region throughout the trunk and the tail of the vertebrates. Soon after gastrulation, the somitic region of vertebrates starts to become segmented into paired blocks of mesoderm, termed somites. This process lasts until the number of somites characteristic of the species is reached. The somites later give rise to all skeletal muscles of the body, the axial skeleton, and part of the dermis. In this review I discuss the processes involved in the formation of the paraxial mesoderm and its segmentation into somites in vertebrates.

Topic: Developmental Biology and Gene Regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Plant Succession on Granite Rock in Eastern North Carolina

1. The transition between Piedmont and Coastal Plain provinces, called the fall line, has numerous outcrops of granitic rock scattered along its length throughout North Carolina, South Carolina, and Georgia. 2. Rocks are unfavorable habitats for plant colonization and these are particularly so because of the long dry summers with high temperatures. Especially adapted plants, including several rock endemics, grow here in spite of the extreme conditions. Succession on the North Carolina rocks follows two major lines, originating (1) anywhere on the rock surface and (2) in depressions. The depressions may be dry, moist, or pools. 3. The bare rock surface is invaded by Grimmia or crustose lichens. The latter do not contribute to further succession. Grimmia forms mats which are successively invaded by stages dominated by (1) Cladonia-Selaginella, (2) Polytrichum, (3) Andropogon, (4) conifers. 4. Dry depressions retain little water and are floored with a clayey soil. The soil is too thin to support species which lead to a successional series and too deep to permit the beginnings of a normal rock succession. They support scattered succulents like Talinum and Portulaca, and sometimes dry, fibrous individuals like Fimbristylis and Stenophyllus. 5. Damp depressions represent the best development on the rocks. The stages are essentially like those on the rock surface but the additional moisture results in richer and more rapid growth, with hardwoods appearing in the later stages. 6. Pools are usually intermittent but regularly support marsh species. The margins have the normal rock series spreading from the pool and Cyperaceae predominate among the soil builders in the water or mud. Late stages are dominated first by mesophytic shrubs and later by hardwoods. 7. Margins are irregular. Where seepage occurs there may be small boggy areas dominated by Sphagnum. Dry margins are usually fixed and rarely show evidence of migration upon the rocks. Shaded margins, protected from washing, produce a distinctive pioneer community upon the debris which accumulates. Entodon is the dominant. 8. The exposures must owe their origin to factors which caused the fall line. Considering the time since this line was formed and the rate of plant succession, it is proposed that the rocks were once entirely covered although probably not so richly forested as the surrounding country. The activities of man resulted in repeated fires and erosion which again uncovered the rock, and today drought, wind-throw, and fire undoubtedly maintain them in their semi-barren condition.

Topic: Botany, Ecology, and Taxonomy Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[The TRIG (Texas Revised Inventory of Grief) questionnaire. French translation and validation].

Bereavement and mourning are normal reactions to the loss of a loved one, characterized by specific ideas, affects, and behavior, evolving spontaneously towards resolution. This syndrome, classified as a non mental disorder (DSM IV), resembles depression. Up to now, there was no instrument for an objective assessment. The general objective of this work was to present the french version of the Texas Revised Inventory of Grief, or TRIG (Faschingbauer, De Vaul & Zisook, 1981), designed to evaluate the intensity of the reaction to the loss of a loved one. Our population is composed of 154 adults of the general population (74 females and 80 males) of the age of 25 to 35 years. A principal component analysis gave us a general factor of grief (28% VT) which gathers emotional reaction to the bereavement. The factorial analysis with Varimax Rotations confirmed the existence of two specific types of grief. These are "past behavior" (reaction at the time of loss) factor (37% VT), "present feelings" (at the time of assessment by TRIG) factor (31% VT). Furthermore, another factor of "related facts" (32% VT) appeared to be in relation with the aptitude of coping. These results allowed us to construct a valid questionnaire of 25 items measuring 3 types of bereavement reactions.

Topic: Grief, Bereavement, and Mental Health
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
A Response to Van Lancker and Sidtis (1992)

No AccessJournal of Speech, Language, and Hearing ResearchSpeech1 Dec 1993A Response to Van Lancker and Sidtis (1992) Kenneth M. Heilman, andUniversity of Florida College of Medicine and Veterans Affairs Medical Center, Gainesville, FL Kenneth M. Heilman University of Florida College of Medicine and Veterans Affairs Medical Center, Gainesville, FL Google Scholar More articles by this author andUniversity of Florida College of Medicine and Veterans Affairs Medical Center, Gainesville, FL https://doi.org/10.1044/jshr.3606.1191a SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "A Response to Van Lancker and Sidtis (1992)." Journal of Speech, Language, and Hearing Research, 36(6), p. 1191 References Ehlers, L., & Dalby, M. (1987). Appreciation of emotional expressions in the visual and auditory modality in normal and braindamaged patients.Acta Neurological Scandinavica, 76, 251–256. CrossrefMedlineGoogle Scholar Heilman, K., Bowers, D., Speedie, L., & Coslett, H. B. (1984). Comprehension of affective and nonaffective prosody.Neurology, 34, 917–921. CrossrefMedlineGoogle Scholar Heilman, K., Scholes, R., & Watson, R. (1975). Auditory affective agnosia: Disturbed comprehension of affective speech.Journal of Neurology, Neurosurgery and Psychiatry, 38, 69–72. CrossrefMedlineGoogle Scholar Tompkins, C. A., & Mateer, C. A. (1985). Right hemisphere appreciation of prosodic and linguistic indication of implicit attitude.Brain and Language, 24, 185–203. CrossrefMedlineGoogle Scholar Tucker, D. M., Watson, R., & Heilman, K. M. (1977). Discrimination and evocation of affectively intoned speech in patients with right parietal disease.Neurology, 27, 947–950. CrossrefMedlineGoogle Scholar Van Lancker, D., & Sidtis, J.J. (1992). The identification of affective-prosodie stimuli by left- and right-hemisphere-damaged subjects: All errors are not created equal.Journal of Speech and Hearing Research, 35, 963–970. ASHAWireGoogle Scholar Additional Resources FiguresReferencesRelatedDetailsCited by Brain and Language57:2 (195-214)1 Apr 1997Unilateral Brain Damage, Prosodic Comprehension Deficits, and the Acoustic Cues to ProsodyMarc D. Pell and Shari R. Baum Aphasiology10:7 (711-721)1 Oct 1996Perceptual and acoustic correlates of affective prosody repetition in transcortical aphasiasMarcelo L. Berthier, Ana Maria Fernández, Eugenio Martínez Celdrán and Jaime Kulisevsky Volume 36Issue 6December 1993Pages: 1191-1191 Get Permissions Add to your Mendeley library History Published in issue: Dec 1, 1993 Metrics Topicsasha-topicsleader-topicsCopyright & PermissionsCopyright © 1993 American Speech-Language-Hearing AssociationPDF downloadLoading ...

Topic: Hearing Impairment and Communication
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Expression of the EVI1 gene in chronic myelogenous leukemia in blast crisis.

The EVI1 gene encodes a nuclear, zinc finger, DNA binding protein expressed after provirus insertion into the Fim-3 or EVI1 loci in murine leukemia myeloid cells. EVI1 is also expressed by cells from AML patients with chromosome rearrangements involving band 3q26, the putative location of the EVI1 gene, but expression of this gene is not detected in normal bone marrow. We report expression of EVI1 by cells from a patient with chronic myelogenous leukemia in blast crisis (CML/BC) whose cells showed inv(3)(q22q26). In vitro culture of these cells resulted in macrophage differentiation and loss of EVI1 expression. Results in this patient suggest EVI1 expression played a role in CML blast transformation. Patients with CML/BC and other nonrandom chromosome abnormalities involving chromosome 3q26 should be evaluated for EVI1 expression.

Topic: Chronic Myeloid Leukemia Treatments
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Clinical-anthropometric characteristics of COPD outpatients belonging to the different groups and having different severity of airway obstruction.

The aim of the study was to compare the clinical and anthropometric characteristics of patients with COPD, which differ in the degree of airways obstruction and belong to groups A, B, C, D in accordance with GOLD, 2011 classification. A total of 112 ambulatory COPD patients in remission made the study sample. Anthropometric data, body mass index, medical history, dyspnea by mMRC scale, and spirometry was performed for all patients. There was confirmed that outpatients with COPD is a heterogeneous group, in which the majority are those with moderate (48.22 %) and severe (30.36 %), airway obstruction. Despite the vast majority of men among outpatients, the percentage of women among patients with mild to moderate obstruction (22.58±5.31 %) was significantly higher (p=0.002) as compared with those with severe or very severe limitation of airflow (6.00±3.36 %). Patients with severe and very severe obstruction were of significantly older age (p = 0.024). At the same time, the distribution of patients according to the GOLD, 2011 classification, demonstrate that all groups did not differ on any of the anthropometric indicators, including gender and age (p > 0.050). Distribution of patients by groups with different risk for future exacerbations is not a mirror image of gradation in accordance with the degree of airway obstruction. Every second (50.00±4.43 % of cases) patient is included in group C and every tenth (10.20±4.32 %) belongs to the group D not due to degree of bronchial obstruction, but due to the number of exa­cerbations in the past year. Therefore, in future studies it is advisable to use both principles of patients’ classification.

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Compact holographic sound fields enable rapid one-step assembly of matter in 3D

Acoustic waves exert forces when they interact with matter. Shaping ultrasound fields precisely in 3D thus allows control over the force landscape and should permit particulates to fall into place to potentially form whole 3D objects in “one shot.” This is promising for rapid prototyping, most notably biofabrication, since conventional methods are typically slow and apply mechanical or chemical stress on biological cells. Here, we realize the generation of compact holographic ultrasound fields and demonstrate the one-step assembly of matter using acoustic forces. We combine multiple holographic fields that drive the contactless assembly of solid microparticles, hydrogel beads, and biological cells inside standard labware. The structures can be fixed via gelation of the surrounding medium. In contrast to previous work, this approach handles matter with positive acoustic contrast and does not require opposing waves, supporting surfaces or scaffolds. We envision promising applications of 3D holographic ultrasound fields in tissue engineering and additive manufacturing.

Topic: Microfluidic and Bio-sensing Technologies
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Unhedgeable Risk: How Climate Change Sentiment Impacts Investment.

Short-term shifts in market sentiment induced by awareness of future, as yet unrealised, climate risks could lead to economic shocks, causing substantial losses in financial portfolio value within timescales that are relevant to all investors. Factors, including climate change policy, technological change, asset stranding, weather events and longerterm physical impacts may lead to financial tipping points for which investors are not presently prepared. This research shows that changing asset allocations among various asset classes and regions, combined with investing in sectors exhibiting low climate risk, can offset only half of the negative impacts on financial portfolios brought about by climate change. Climate change thus entails “unhedgeable risk” for investment portfolios. While the response to action aimed at limiting warming below 2°C is shown to be negative in its short-term economic and financial impacts, the benefits of early action lead to significantly higher economic growth rates and returns over the long run, especially when compared to a worst-case scenario of inaction. The present study shows that certain types of portfolio benefit more than others. Even in the short run, the perception of climate change represents an aggregate risk driver that must be taken into consideration when assessing the performance of asset portfolios. Our analysis provides investors with a general guide to minimising their exposure to climate sentiment risk and has the potential to stimulate a constructive dialogue between investors, governments and regulators to examine the conditions necessary to build more resilient financial markets under unprecedented environmental change.

Topic: Market Dynamics and Volatility
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Writing a winning FRGS proposal

Writing a winning research proposal for Fundamental Research Grant of the Malaysian Ministry of Education is not always easy. Many applicants even could not secure the grants. There have been numerous approaches used by different academicians. Similarly, various seminar on have been conducted to generate competitive research proposal to secure the grants. However, there has been no consensus on how to prepare successful research proposal among scholars and policy makers. In view of this, the paper addresses the issue by observing certain guidelines provided by the grant providers as a way to successfully prepare a competitive research proposal. In this relation, Fundamental Research Grant Scheme (FRGS) is not exceptional to this that understanding the criteria required is a fundamental factor to secure the grant.

Topic: Education and Islamic Studies
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Bethe ansatz solutions for Temperley-Lieb quantum spin chains

We solve the spectrum of quantum spin chains based on representations of the Temperley-Lieb algebra associated with the quantum groups U-q(X-n) for X-n = A(1), B-n, C-n and D-n. The tool is a modified version of the coordinate Bethe ansatz through a suitable choice of the Bethe states which give to all models the same status relative to their diagonalization. All these models have equivalent spectra up to degeneracies and the spectra of the lower-dimensional representations are contained in the higher-dimensional ones. Periodic boundary conditions, free boundary conditions and closed nonlocal boundary conditions are considered. Periodic boundary conditions, unlike free boundary conditions, bleak quantum group invariance. For closed nonlocal cases the models are quantum group invariant as well as periodic in a certain sense.

Topic: Algebraic structures and combinatorial models
Subfield: Geometry and Topology
Field: Mathematics
Domain: Physical Sciences
Clinical features

This disorder has failed to achieve the status of general recognition among the cephalic neuralgias. Whether its orphanage derives from narrow-minded expulsion from the neuro-logical domain of cephalic neuralgias to the ENT-field, or can be attributed to its rarity (though this did not keep glossopharyngeal neuralgia from rightfully assuming its place among equals), or to the hazy outlines of the disorder, remains a question more readily posed than answered. Yet, if it shares with Sluder’s sphenopalatine neuralgia an uncertain clinical identity, there are a sufficient number of observable clinical data from which to conclude the reality of this neuralgia. A review of pertinent reports should enable the reader to make up his own mind.

Topic: Trigeminal Neuralgia and Treatments
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Affect in the circulation of cultural forms

A three-tier semiotic model is used to explore the affective impulsion of cultural forms. At the first tier, indexical and iconic signs, such as cry breaks and pitch raising, evoke feelings and emotions stimulating the replication of cultural forms as expressions of personal experiences. At a second tier, cultural forms convey prior or even imaginary conditions via semantic meanings; those conditions engender virtual icons and indices operating analogously to those in the base layer. At the third tier, conditional propositions, themselves seemingly devoid of emotion, produce stories based on failures of their underlying desirability logic; such stories evoke powerful and widely circulated affects.

Topic: Language, Metaphor, and Cognition
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Analysis of a heat wave induced by laser radiation absorption in an optical fiber on the basis of a 2D nonstationary heat conduction equation

A heat wave resulting from the absorption of laser radiation in the core of an optical fiber is studied using a nonstationary 2D heat conduction equation. The velocity of the wave as a function of the laser intensity is determined, and the threshold intensity generating the heat wave is calculated. At high intensities, the velocity of the wave can be qualitatively described by a well-known formula from combustion theory; i.e., the velocity is shown to be proportional to the square root of the radiation intensity. The analytical threshold laser intensities closely agree with the available experimental data.

Topic: Laser Material Processing Techniques
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Polynomial time guarantees for sampling based posterior inference in high-dimensional generalised linear models

The problem of computing posterior functionals in general high-dimensional statistical models with possibly non-log-concave likelihood functions is considered. Based on the proof strategy of Nickl and Wang (2022), but using only local likelihood conditions and without relying on M-estimation theory, nonasymptotic statistical and computational guarantees are provided for a gradient based MCMC algorithm. Given a suitable initialiser, these guarantees scale polynomially in key algorithmic quantities. The abstract results are applied to several concrete statistical models, including density estimation, nonparametric regression with generalised linear models and a canonical statistical non-linear inverse problem from PDEs.

Topic: Statistical Methods and Inference
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Regional Commission. FEEDING VALUE OF PACIFIC NORTHWEST-GROWN SOYBEANS FOR BROILERS

Two broiler feeding experiments were carried out to determine the feeding value of Pacific Northwest-grown soybeans. In both experiments, solvent soy-bean meal (SBM) protein, when replaced one to one with extruded soybean (ESB) protein, produced no significant effects on body weight, feed conversion and mortality. Protein from raw soybean (RSB) could replace up to 50 percent of SBM protein in the ration. Higher levels of RSB significantly depressed growth and feed conversion. The supplementation of zinc bacitracin to RSB rations did not overcome the inhibitory effects. Supplementing an additional 0.05 percent methionine in the RSB ration also did not improve growth rate and feed conversion. RSB-fed broilers had significantly (P&amp;lt; 0.05) larger pancreata, kidneys and proventriculi than the SBM-fed birds. Only pancreatic weights were affected in ESB-fed birds. Wetter caked floor litter was ob-served in pens that housed broilers fed RSB than either ESB or SBM. Mortality was greater where high levels of RSB was included in the rations.

Topic: Animal Nutrition and Physiology
Subfield: Animal Science and Zoology
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Laser-Induced Breakdown Spectroscopy: Capabilities and Applications

Abstract : This work provides a review of the capabilities and applications of laser-induced breakdown spectroscopy (LIBS) at the U.S. Army Research Laboratory (ARL). By coupling advances in LIBS hardware and analysis software, ARL has expanded the capabilities of LIBS significantly. LIBS uses a focused, pulsed laser to ablate a target material, generating a transient microplasma which emits light characteristic of the sample composition. It is a real-time sensor technology which requires no sample preparation and provides universal materials detection for solids, liquids, and aerosols. Applications investigated at ARL in recent years include the standoff detection of explosive residues and other hazardous materials, plastic landmine discrimination, and material characterization of various metal alloys and polymers.

Topic: Laser-induced spectroscopy and plasma
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences