jimnoneill/paper-to-field-training huggingface dataset:
[Development of lipomas on a surgical wound following radial saphenectomy. An unusual complication].

Radical saphenectomy is a common practice in treatment of the varicose veins of the limbs, and its early and late complications are very well known. Nevertheless, the authors have observed an exceptional pathologic picture in one patient operated five years ago, which developed multiple nodular lipomas in the sites of the surgical scars for varicectomy. This unusual complication, in spite of lack of clear etiopathogenesis, suggest to reduce as less as possible the surgical subcutaneous traumatism.

Topic: Body Contouring and Surgery
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
<i>IL6</i>, Aspirin, Nonsteroidal Anti-inflammatory Drugs, and Breast Cancer Risk in Women Living in the Southwestern United States

Abstract Interleukin-6 is a cytokine thought to be involved in inflammation, insulin, and estrogen-related pathways. We evaluate genetic variation in the IL6 gene with risk of breast cancer. We also evaluate breast cancer associations with aspirin and nonsteroidal anti-inflammatory drugs. A breast cancer case-control study (n = 1,527 non-Hispanic white cases, 1,601 non-Hispanic white controls, 798 Hispanic/Native American cases, and 924 Hispanic/Native American controls) was conducted among women living in the southwestern United States (4-Corner's Breast Cancer Study). Five IL6 single nucleotide polymorphisms (SNP) and IL6 haplotypes based on these SNPs were evaluated. Allele frequencies were significantly different between non-Hispanic white and Hispanic/Native American women. Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (−596A&amp;gt;G) and the GC/CC genotypes of rs1800795 (−174G&amp;gt;C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively). Haplotypes of the five IL6 SNPs further defined these associations. Recent aspirin use significantly decreased risk of breast cancer among postmenopausal Hispanic/Native American women not recently exposed to hormones (OR, 0.56; 95% CI, 0.33-0.96). Among non-Hispanic white, the inverse association with aspirin was not statistically significant. IL6 genotype and haplotype significantly modified the association between aspirin and breast cancer, with the greatest effect modification being among women not recently exposed to hormones [P interaction = 0.06 (for non-Hispanic white) and 0.04 (for Hispanic/Native American) and SNP rs1800796 or −572G&amp;gt;C]. These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(4):747–55)

Topic: Inflammatory mediators and NSAID effects
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Comparative Histomorphological Studies on Oesophagus of Catfish and Grass Carp

The present work was carried out on 40 specimens of oesophaguses of both sexes of catfish (carnivorous fish) and grass carp (herbivorous fish) in order to observe the morphological and histological differences between the two species. Oesophagus of catfish was divided into 2 parts: anterior and posterior ones. The anterior part of the oesophagus of catfish was characterized by the presence of numerous mucosal folds. It was lined by stratified epithelium with goblet cells. In addition to club cells were observed in between the stratified epithelium. Scanning electron examination of the oesophageal epithelium of catfish demonstrated the presence of microvilli and fingerprint-like microridges in the superficial cell layer. The posterior part of the oesophagus of catfish was characterized by simple columnar mucus-secreting epithelium. The oesophagus of grass carp had shown the same structure along its entire length. It consisted of less folded mucosa than that observed in the oesophagus of catfish. The epithelium was characterized by the presence of taste buds. In conclusion, the present work revealed some differences in the structure of catfish oesophagus and grass carp oesophagus. These differences are related to type of food and feeding habits of each species.

Topic: Aquaculture disease management and microbiota
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Environmental management and ISO 14000: ISO/Swiss government regional itinerant training seminar for developing and emerging countries

Conclusions: The authors were impressed with the organisation of these seminars and the warm hospitality they received. The positive attitude of everyone concerned was extremely motivating. Events such as these are vital in disseminating know-how of LCA into these countries. It was and will be a big opportunity to introduce LCA together with environmental management systems and eco-labelling under the umbrella of the ISO 14000 series. In this respect organisations have the chance to choose from a number of tools to meet a variety of needs and situations. Further seminars and more detailed information are necessary. It is in everyone's best interests that organisations in developing countries have access to the management tools which allow them to operate in an environmentally responsible manner. For future activities it is believed that the principle "train the trainersâ would be the most beneficial approach. To conclude it must be stated that these events were a great experience for all involved, both participants and lecturers

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Usefulness of Cepstral Peak Prominence (CPP) in Unilateral Vocal Fold Paralysis Dysphonia Evaluation

Background and Objectives The purpose of this study was to compare the usefulness of Cepstral peak prominence (CPP) with parameter of Multiple Dimensional Voice Program (MDVP) in evaluating unilateral vocal fold paraylsis patients with subjective voice impairment. Materials and Methods From July 2014 to August 2016, 37 patients with unilateral vocal fold paralysis who had been diagnosed with unilateral vocal fold paralysis and had received two or more voice tests before and after the diagnosis were evaluated for maximum phonation time (MPT), MDVP and CPP. Respectively. Voice tests were performed with short vowel /a/ and paragraph reading. Results The CPP-a (CPP with vowel /a/) and CPP-s (CPP with paragraph reading) of the Cepstrum were statistically negatively correlated with G, R, B, and A before the voice therapy. Jitter, Shimmer, and NHR of MDVP were positively correlated with G, R, B. Jitter, Shimmer, and NHR of the MDVP were significantly correlated with the Cepstrum index. G, B, A and CPP-a and CPP-s showed a statistically significant negative correlation and a somewhat higher correlation coefficient between 0.5 and 0.78. On the other hand, in MDVP index, there was a positive correlation with G and B only with Jitter of 0.4. Conclusion CPP can be an important evaluation tool in the evaluation of speech in the unilateral vocal cord paralysis when speech energy changes or the cycle is not constant during speech. Key words: Cepstrum ã Acoustic analysis ã Vocal fold paralysis íµì¬ì©ì´: ì±ëë§ë¹ ã ì¼ì¤í¸ë¼ ã ë°ì±ì¥ì

Topic: Voice and Speech Disorders
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Factors for absolute Cesaro summability

In this paper using $ \delta $-quasi-monotone sequences a theorem on $ | C, \alpha, \beta; \delta |_k $ summability factors of infinite series, which generalizes a theorem of Mazhar[6] on $ | C, 1 |_k $ summability factors, has been proved.

Topic: Approximation Theory and Sequence Spaces
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
NEUROFIBROMATOSIS OF THE BLADDER

SUMMARY A case is reported of neurofibromatosis of the urinary bladder in association with vesical diverticula, one of which contained a papillary carcinoma. The condition occurred in a 47‐year‐old male with von Recklinghausen's disease. The literature on the subject is reviewed.

Topic: Urinary and Genital Oncology Studies
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation

Megakaryocyte growth and development factor (MGDF) is a recently characterized ligand for the cell surface receptor mpl. We have evaluated the effects of polyethylene glycollated recombinant human MGDF (PEG-rHuMGDF) on recovery of hematopoietic cells in mice following bone marrow transplantation (BMT) to support lethal irradiation. Mice treated with PEG-rHuMGDF (50 micrograms/kg/d) had accelerated recovery of platelet numbers compared with BMT mice treated with carrier or recombinant human granulocyte colony-stimulating factor (rHuG-CSF, 72 or 200 micrograms/kg/d). In contrast, PEG-rHuMGDF had no effect on white blood cell (WBC) or red blood cell (RBC) recovery. As previously reported, animals treated with rHuG-CSF had an enhanced recovery of WBC but not platelet or RBC levels. Interestingly, BMT receipient mice treated with the combination of PEG-rHuMGDF and rHuG-CSF showed simultaneous enhanced recovery of both leukocytes and platelets. PEGylated rHuMGDF was found to be considerably more potent than non- PEGylated rHuMGDF in this setting. PEG-rHuMGDF is an effective growth factor for enhancing platelet recovery in mice following BMT either alone or in combination with rHuG-CSF. It will be of interest to evaluate in a clinical setting the ratios of PEG-rHuMGDF and rHuG-CSF for simultaneous administration of these factors and accelerated recovery of both leukocytes and platelets.

Topic: Platelet Disorders and Treatments
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Tectonics and Sedimentation in the Panama Basin: Geologic Results of Leg 16, Deep Sea Drilling Project

DSDP Sites 155, 157, and 158 of Leg 16, and Site 84 of Leg 9 have broadly defined the depositional history of the Panama Basin and provided constraints as to its tectonic evolution.Only during the last 5 m.y.have the depositional histories of DSDP 157, 84, and 158 (the continuously cored sites) diverged strongly.DSDP 157 contains a fairly uniform sequence of carbonate-rich oozes and chalks, whereas the upper sections of DSDP 84 and 158 become progressively richer in volcanic and terrigenous debris and 158 shows a decrease in sedimentation rate from the late Miocene until the late Quaternary.These changes apparently resulted from separation of the sites due to spreading along the Galapagos Rift Zone; movement of DSDP 84 and 158 out of the productive zone along the northern fringe of the Peru Current; influx of hemipelagic sediments as the northern sites approached Central America; influx of volcanic debris to DSDP 84 from the active Coiba Fracture Zone; and a general rise in the lysocline during the late Cenozoic coupled with the normal rise of this feature along a continental margin.The basalts cored at the Leg 16 sites are more fractionated than mid-ocean ridge tholeiites, suggesting that they are derived from a "hot spot," such as the Galapagos.The depositional histories, basement compositions, and basement ages of the DSDP sites suggest that the aseismic ridges of the Panama Basin formed from the Galapagos volcanic center and the Basin itself developed by spreading along a formerly more extensive Galapagos Rift Zone during the past 15 million years.

Topic: Botany and Geology in Latin America and Caribbean
Subfield: Ecology, Evolution, Behavior and Systematics
Field: Agricultural and Biological Sciences
Domain: Life Sciences
A Study of Youth Volleyball Playersâ€™ Participation Motivation and Relate Elements*

The present study examined the essential factors that truly motivated youth athletes participated in Volleyball practices and competitions using the Adapted Questionnaire of Volleyball Athleteâ€™s Motivation-Chinese Version. Participants were 92 youth volleyball athletes (age 14-17) from 15 schools of Nanjing City, China. Data analysis was done by a 2 Gender (boy or girl) x 2 Education-levels (high-school or middle-school) x 2 School-types (sport-school or regular-school) multivariate analysis of variance (MANOVA). Findings included: the top five higher scores from the 19 RFs were: RF1 â€œTechnical-content and unique-valueâ€ M Â± SD = 4.30 Â± .83; RF17 â€œFor extraordinary-skillsâ€ M Â± SD = 4.24 Â± 1.04; R3 â€œFor healthâ€ M Â± SD = 4.11 Â± 1.02; RF12 â€œImprove own-literacyâ€ M Â± SD = 4.00 Â±1.26; RF9 â€œbecome healthierâ€ M Â± SD = 3.58 Â±1.13. These RFs possess significant higher impact on the participantsâ€™ motivations. The results of the MANOVA revealed that: two out of three independent variables reached meaningful significantly difference level (p &lt; .00), wherein in â€˜Genderâ€™ aspect, Î› = .37, F = 5.92 with boys athletesâ€™ motivation score significantly higher (p &lt; .00) than the girls athletes; (2) in â€˜School-typesâ€™ aspect, Î› = .24, F =11.17 with sport-school playersâ€™ motivation score significantly higher (p &lt; .00) than the regular-school players.

Topic: Motivation and Self-Concept in Sports
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
External Fixation in Experimental Scoliosis.

The purpose of this experimental study was to investigate the effects of spinal external fixation in scoliosis. Two of four ribs on the right side of growing rabbits were partially resected. Between 4 and 6 weeks later, moderate right-convex thoracic scoliosis had developed. Then, in seven rabbits, a mini-Orthofix or fixano fixator was attached by Kischner wires to T9/10 and L1/2. The average Cobb angle was 27.1 degrees before external fixation, and was 13.6 degrees at initial correction just after attaching the fixator. In three of these, the fixators were removed at more than 8 weeks after the operation. Only slight progressive vertebral curvature was seen in these rabbits after removal of the fixator, with a relatively good effect of prophylaxis of progression compared to the controls. We propose that the effects of this spinal external fixation for scoliosis was due to correction of the axial rotation at the apical vertebra rather than to the traction force.

Topic: Scoliosis diagnosis and treatment
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Improvement of the strategy of insolvent organisations crisis recovery

The article presents the research results aimed at strategic management of an insolvent organisation to overcome the financial and economic crisis. Nowadays enterprises in Kazakhstan often have challenges with ensuring financial stability and solvency. As a result, many organisations become uncompetitive. It can cause a business bankruptcy. The article highlights modern issues of ensuring domestic commercial organisations financial stability. The paper proposes solutions available to improve an economic efficiency mechanism for managing the financial condition of insolvent organisations. Therefore, an integrated approach to the development and implementation of strategies to recover insolvent organisations from crisis includes financial recovery, optimisation of operational processes, management reorganisation, reorientation to new markets and products, strengthening marketing activities, and improving corporate culture. Each of these strategies is aimed at stabilising the financial condition, increasing efficiency, and competitiveness. The implementation of these strategies requires all organisation departments coordinated actions and adaptation to current economic conditions.

Topic: Banking, Crisis Management, COVID-19 Impact
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Leucaena leucocephala (Lam.) de Wit 21617

Plant Genetic Resource.<br>Taxonomy: Leucaena leucocephala (Lam.) de Wit<br>Common name(s): Forages<br>Conserved by: International Livestock Research Institute (ILRI-Ethiopia), Ethiopia<br>Local sample unique identifier: 21617<br>Method of creation: Acquisition<br>Date: 2001-07-20<br>Other identifiers: n/a,CPI 92612<br>Historical: No<br>Biological status: Wild<br>MLS status: Included

Topic: Antimicrobial Resistance in Staphylococcus
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
SH1243979.08FU

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.

Topic: Wheat and Barley Genetics and Pathology
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Enhanced recA Protein Binding to Z DNA Represents a Kinetic Perturbation of a General Duplex DNA Binding Pathway

recA protein binding to duplex DNA is enhanced when a B form DNA substrate is replaced with a left-handed Z form helix. This represents a kinetic rather than an equilibrium effect. Binding to Z DNA is much faster than binding to B DNA. In other respects, binding to the two DNA forms is quite similar. recA protein binds to B or Z DNA with a stoichiometry of 1 monomer/4 base pairs. The final protein filament exhibits a right-handed helical structure when either B or Z form DNAs are bound. There are only two evident differences: the kcat for ATP hydrolysis is reduced 3-4-fold when Z DNA is bound, and recA binding at equilibrium is less stable on Z DNA than on B DNA. At steady state, the binding favors B DNA in competition experiments. The results indicate that Z DNA binding by recA protein follows the same pathway as for recA binding to B DNA, but that the nucleation step is faster on the Z form helix.

Topic: DNA and Nucleic Acid Chemistry
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Sustainability of TQM Implementation Model In The Indonesia’s Oil and Gas Industry: An Assessment of Structural Relations Model Fit

This study purposively is to conduct an empirical analysis of the structural relations among critical factors of quality management practices (QMPs), world-class company practice (WCC), operational excellence practice (OE), and company performance (company non-financial performance or CNFP and company financial performance or CFP) in the oil and gas companies operating in Indonesia. The current study additionally examines the relationships between QMPs and CFP through WCC, OE, and CNFP (as partial mediators) simultaneously. The study uses data from a survey of 140 strategic business units (SBUs) within 49 oil and gas contractor companies in Indonesia. The findings suggest that all six QMPs have positive and significant indirect relationships on CFP through WCC and CNFP. Only four of six QMPs have positive and significant indirect relationships on CFP through OE and CNFP. Hence, WCC, OE, and CNFP play as partial mediators between QMPs and CFP. CNFP has a significant influence on CFP. A major implication of this study is that oil and gas managers need to recognize the structural relations model fit by developing all of the research constructs simultaneously associated with a comprehensive TQM practice. Furthermore, the findings will assist oil and gas companies by improving CNFP, which is very critical to TQM, thereby contributing to a better achievement of CFP. The current study uses the Deming’s principles, Hayes and Wheelwright dimensions of world-class company practice, Chevron Texaco’s operational excellence practice, and the dimensions of company financial and non-financial performances. The paper also provides an insight into the sustainability of TQM implementation model and their effect on company financial performance in oil and gas companies in Indonesia.

Topic: Reservoir Engineering and Simulation Methods
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Analysis of the architecture of the heterodimeric Get1-Get2 insertase and the inhibition of tail-anchored protein biogenesis by Retro-2

Tail-anchored (TA) proteins, including SNAREs involved in vesicle transport, are post-translationally targeted to the endoplasmic reticulum membrane by the guided entry of tail-anchored proteins (GET) pathway in yeast and the transmembrane domain (TMD) recognition complex (TRC) pathway in mammals. The conserved targeting factor Get3 (in yeast; ASNA1 in mammals) binds the carboxyl-terminal TMD of TA proteins and forms a targeting complex, which engages its integral heterodimeric receptor at the ER membrane for TMD release and insertion into the lipid bilayer. \nI first addressed the structure and stoichiometry of the yeast Get1-Get2 complex. In vivo site-specific crosslinking and accessibility assays revealed an aqueous interface between the transmembrane regions of Get1 and Get2. To distinguish between competing models for how the Get1-Get2 heterodimer interacts with the Get3-TA targeting complex and mediates TMD insertion, I reconstituted a single-chain version of Get1-Get2 complex into proteoliposomes and nanodiscs. In vitro assays, alongside fluorescence tools, showed a single copy of the Get1-Get2 heterodimer is sufficient to recruit the Get3-TA targeting complex and insert the TMD into the ER membrane.\nNext, I investigated the mechanism of action of the small molecule Retro-2, which protects cells from toxins and pathogens that exploit vesicular trafficking. Genetic profiling analysis revealed that Retro-2 treatment resembles inhibition of the TRC pathway. Using dual-colour self-cleaving fluorescent reporters, I showed the compound inhibited TA protein biogenesis in mammalian cells. In vitro assays further revealed the mechanism of action in which Retro-2 blocks the transfer of newly-synthesized TA proteins from the upstream chaperone SGTA to ASNA1. These data propose a model in which Retro-2 directly inhibits ASNA1-mediated TA protein targeting, leading to the depletion of the SNAREs that mediate vesicular transport, and thus ultimately preventing the entry or replication of various pathogens.

Topic: Pancreatic function and diabetes
Subfield: Surgery
Field: Medicine
Domain: Health Sciences