jimnoneill/paper-to-field-training huggingface dataset:
Treating Hip Fractures with the Novel DHS Fixation Technique without the Use of Traction Table

Aim: To assess a novel method of traction-free Dynamic Hip Screw (DHS) fixation. Method: 100 patients who had manual traction for DHS fixation between July 2020 and July 2021 had their results in terms of tip apex distance (TAD), fracture reduction quality, length of the procedure, and preoperative preparation time assessed. Result: Good to moderate decrease was possible in 96% of instances. The average screw cutout frequency was only 0.90%, the mean TAD was 19.1 millimetres, and the average operating time was 35 minutes. Conclusion: This method is very helpful for polytrauma patients who require multiple surgeries because it is simple, repeatable, affordable, and doesn’t lose reduction alignment or screw position.

Topic: Hip and Femur Fractures
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Structural Basis for Dynamic Mechanism of Proton-Coupled Symport by the Peptide Transporter POT

Membrane transporters transport their substrates across the membrane, thereby contributing to the maintenance of the cellular environments. One of the largest superfamily of the membrane transporters is Major Facilitator Superfamily (MFS), and many of MFS transporters are involved in the cellular uptake of various compounds utilizing the proton motive force across the membrane. Although several crystal structures of MFS transporters have been reported so far, their active transport mechanism has still remained elusive. Proton-dependent oligopeptide transporter, POT, is a member of MFS, and is involved in the uptake of oligopeptides as well as peptide-like drugs. In this article, we explain the active transporter mechanism by POT based on our recent results of the structural and computational analyses.

Topic: Amino Acid Enzymes and Metabolism
Subfield: Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Junctive Compositions of Specifications in Total and General Correctness

First against a conventional total-correctness background of wp semantics, we define a small family of compositions for predicate-pair specifications based on simple logical conjunction and disjunction, discussing the formal properties and offering an intuitive operational interpretation of each. Three of these compositions we recognise as familiar; the fourth one, our concert, is new but lacks any apparent use. Then we re-interpret our compositions in the context of general correctness to very useful effect.

Topic: Logic, programming, and type systems
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
RETAIL LOAN PERFORMANCE IN INDIA: AN EMPIRICAL STUDY IN PUBLIC AND PRIVATE SECTOR BANKS

Using an empirical methodology, this study investigates the performance of retail loans in Indian public and private sector banks, with a focus on house and education loans. It seeks to assess important performance metrics including borrower satisfaction, default rates, repayment trends, and loan disbursement trends. 120 respondents, evenly divided across the two banking sectors, provided primary data using structured questionnaires as part of a descriptive study methodology. According to the data, public sector banks are more active in offering education loans while having higher default rates, whereas private sector banks perform better in terms of efficiency, recovery rates, and customer satisfaction, particularly in the housing loan area. Suggestions for enhancing risk management and service provision in retail banking are included in the study's conclusion.

Topic: Banking Sector Performance and Management
Subfield: Accounting
Field: Business, Management and Accounting
Domain: Social Sciences
German Research Budget: Less Money, But Much Needed Reform

Heidelberg—Jurgen Ruttgers, Germany9s minister for science and education, had good and bad news for the country9s scientists last week. After weeks of speculation, while the federal government hammered out massive budget cuts for 1997, his ministry emerged with $10 billion—2.5% less than last year, the second straight year of cuts. The most conspicuous victim appears to be the German Space Agency, DARA, which will be disbanded and some of its functions taken over by the Aerospace Research Establishment. But Ruttgers added a positive spin with a set of proposals to bring much-needed reform to many of Germany9s nonuniversity research centers: more autonomy, less red tape, and more competition in funding.

Topic: International Science and Diplomacy
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Programmable System on Chip Distributed Communication and Control Approach for Human Adaptive Mechanical System

Abstract: Problem statement: Communication and control are two main components in any Mechatronics system. They can be designed either by centralized or decentralized approach. Both approaches can be chosen based on application designed and specific requirements of the designer. In this study, decentralized or normally called distributed approach was selected to solved communication and control of a human adaptive mechanical system namely Intelligent Chair Tools (ICT). The ICT seating system is powered by thirty six intelligent pneumatic actuators to facilitate investigation of chair shapes from spring and damping effect of seating and backrest surface. Three studies are proposed from the sitting experiments namely chair shapes, chair spring and chair damping properties. Approach: PSoC microcontroller was selected based on its features of having configurable analog and digital blocks. Its flexible modules and programmable peripherals ease designer in designing the communication and control of ICT in improved and faster way. Three protocols of USB, SPI and I 2 C were used for the communication system of ICT using PSoC. Flow charts of each communication protocols algorithms were discussed. On the other hand, the control system used PSoC’s ADC and counter modules to read inputs of pressure and encoder respectively. PWM module is used to control the valve and data communication was achieved using I 2 C module. Block diagram of unified control

Topic: Sexual function and dysfunction studies
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Line 211 spring wheat

Red-seeded spring wheat germplasm line 211 has high levels of seed dormancy. Its agronomic performance is comparable to that of the cultivars Katepwa and AC Domain. Line 211 has a heavier kernel with soft endosperm texture. Key words: Triticum aestivum L., germplasm, seed dormancy, pre-harvest sprouting resistance

Topic: Agricultural Productivity and Crop Improvement
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) May Be an Alternative Preventive Therapy in Children with Cerebral Palsy.

Daily application of 10% w/v CPP-ACP paste is effectively changes saliva buffering capacity and plaque pH, thus promoting caries prevention in the primary and mixed dentition of CP children.

Topic: Dental Health and Care Utilization
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Linezolid Pharmacokinetics in Adult Patients with Cystic Fibrosis

ABSTRACT The pharmacokinetics of many drugs are altered in patients with cystic fibrosis (CF), often necessitating different dosage requirements than those used in non-CF patients. The objective of this study was to determine the pharmacokinetics of linezolid, an antibiotic with good activity against gram-positive organisms such as methicillin-resistant Staphylococcus aureus , in patients with CF so that dosage requirements could be established. Twelve adult patients (6 male) ranging in age from 22 to 39 years were studied. A single 600-mg dose was administered intravenously over 0.5 h, and plasma samples were collected at 0 (predose), 0.5, 0.75, 1, 2, 4, 8, and 24 h. Linezolid concentrations were determined with a validated high-performance liquid chromatography assay. Pharmacokinetic parameters were estimated using standard noncompartmental methods. Blood chemistry and hematologic indices were determined before and after the study for safety purposes. All patients completed the study without encountering any adverse reactions. The pharmacokinetic parameters, while variable, with half-lives varying from 1.76 to 8.36 h, were similar to those previously described in other populations. Mean (± standard deviation) values for pharmacokinetic parameters of interest were as follows: elimination rate constant, 0.21 (0.11) h −1 ; half-life, 4.41 (2.43); volume of distribution at steady state, 0.87 (0.19) liters/kg of body weight; and total body clearance, 0.12 (0.06) liters/h/kg. No patient would have achieved the pharmacodynamic target of an area under the concentration-time curve/MIC ratio of 83 h for pathogens for which the MIC was 4 μg/ml. Patients with inadequate clinical responses to linezolid may require more frequent dosing.

Topic: Antimicrobial Resistance in Staphylococcus
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
The effect of feeding fresh swine manure, poultry waste, urea, molasses and bakery by-products ensiled for lambs

Introduction The use of by-products such as swine manure (SM), poultry waste (PW), urea (U), molasses (M) and bakery by-product (BB) is an alternative method for lamb feeding. The objective of the present study was to determine the chemical composition, dry matter intake and digestibility in growing lambs using ensiled PW combined with BB (PWBB), SM with BB (SMBB), SM with M (SMM) and U with M (UM) in their diets. Methods Four silagesâPWBB, SMBB, SMM and UMâ were prepared, the chemical composition of the silages was determined (n = 3), silages and concentrate ratio (60:40) as fresh matter were given to growing lambs over 21 days as total period, and the collection of samples to determine intake and digestibility was carried out for the last 7 days, in a 4 9 4 Latin square design, with a significance level P.05. Results The organic matter (OM) was lower (P.05) in silage with SMM (886 g/kg), and crude protein increased with UM (206 g/kg) followed by PWBB (170 g/ kg). DM, OM, NDF and ADF intake was higher (P.05) in UM diets compared with the rest of the treatments; ADF digestibility was lower (P.05) for SMM (389 g/kg) than UM (417 g/kg) diets. N intake was higher (P.05) in UM (51.3 g N/day) diets than the rest of the treatments (39.9 ± 1.3 g N/day). Conclusions The use of PWBB, SM combined with BB or M is an alternative method for lamb feeding, provided that a proper formulation supplies the nutrient requirements of crude protein and diminish the N excretion compared with UM diet.

Topic: Ruminant Nutrition and Digestive Physiology
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Chiromagnetic Co(OH)<sub>2</sub> nanoparticles with high asymmetry for electrochemical recognition and detection of ascorbic acid enantiomers

Chiromagnetic Co(OH) 2 nanoparticles with tunable asymmetry g -factors achieve AA chiral recognition and nM-level concentration detection.

Topic: Advanced biosensing and bioanalysis techniques
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Effect of tumor necrosis factor antibody given to horses during early experimentally induced endotoxemia

Abstract Objective To test efficacy of murine monoclonal, rabbit polyclonal recombinant equine or human tumor necrosis factor-α (rETNF or rHTNF, respectively) antibodies to inhibit native equine tumor necrosis factor (TNF) activity. Animals 8 and 18 healthy adult horses for parts 1 and 2 of the study, respectively. Procedures In part 1, supernates from endotoxin-activated peritoneal macrophages were incubated with various dilutions of each rETNF antibody and subsequently tested for TNF activity. Serum was also obtained from a horse 1 hour after infusion with 20 ng of endotoxin/kg of body weight and was incubated with various dilutions of rabbit polyclonal rHTNF antibody. In part 2, 20 ng of endotoxin/kg was infused in horses during a 30-minute period. Fifteen minutes after the endotoxin infusion was initiated, 1 of 3 preparations was infused: 0.1 mg of rabbit polyclonal rHTNF antibody/kg, 0.1 mg of human IgG/kg, or 500 ml of 5% dextrose. Clinical and hematologic data were collected for 24 hours. Results Compared with the monoclonal antibody, the rabbit polyclonal rETNF antibody was more effective in inhibiting TNF activity. The 50% effective doses of the murine monoclonal rETNF, rabbit polyclonal rETNF, and rabbit rHTNF antibodies were 1.8, 0.8, and 0.6 μg of antibody/ml, respectively. In part 2, endotoxin infusion resulted in significant alternations in all variables; however, differences among treatment groups were not significant. Conclusions and Clinical Relevance Although murine monoclonal and rabbit polyclonal rETNF or rHTNF antibodies are capable of inhibiting native equine TNF activity in vitro, when given after initiation of endotoxemia, administration of 0.1 mg of rabbit polyclonal rHTNF/kg does not alter the response to infusion of endotoxin. ( Am J Vet Res 1998;59:792-797)

Topic: Immune Response and Inflammation
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
[Comparative study of interventricular electrical and mechanical synchrony at different cardiac pacing sites].

Compared with right ventricular apical pacing and right ventricular outflow tract ventricular septal pacing, left ventricular outflow tract septum has a smaller impact on the electro-mechanical synchronization. It conforms more closely to the physiological pacing so that there is a higher synchronization of electrical and mechanical ventricular contractions.

Topic: Cardiac pacing and defibrillation studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Belief in UFOs as alternative reality, cultural rejection or disturbed psyche

No paranormal phenomenon has so captured public attention and has so permeated contemporary popular culture as have the so‐called “Unidentified Flying Objects” (UFOs). However, few empirical studies exist to explain why some believe UFOs are alien spacecraft while others do not. Survey data (N= 453) were collected to test three commonly advanced explanations of belief in UFOs as alien spacecraft. The “alternative reality” theory claims that UFO believers are simply those caught up in the awe and excitement of possible extraterrestrial life. Such believers believe because they want to, and they are also more psychologically involved with science fiction and with mysticism. The “cultural rejection” thesis is that UFO believers are social marginals and cultural “outsiders” who express their alienation by adopting deviant beliefs. The “disturbed psyche” theory holds that UFO believers are distressed, troubled, unhappy, or maladjusted persons susceptible to “primitive” thinking and delusions. The data analysis supported only the alternative reality theory and further found UFO believers much more involved with science fiction than with mysticism.

Topic: Paranormal Experiences and Beliefs
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
THE EFFECT OF JOB MONITORING AND ORGANIZATIONAL COMMUNICATION ON EMPLOYEE’S JOB EFFECTIVENESS

This study aimed to examine the effect of job monitoring and organizational communicationon employee’s job effectiveness. The author utilized a descriptive study method and a verification method. The study population was all employees of BPJS KC Kuningan amounted to 30 people. The sample amount determination was conducted using a saturated sample. The number of samples taken in the study follows the population, i.e., 30 respondents. The study result shows that a hypothesis stating that job monitoring partially and significantly affects employee’s job effectiveness was supported. The second hypothesis was also supported, where a positive and significant effect is present between organizational communication and job effectiveness.

Topic: Employee Performance and Management
Subfield: Human Factors and Ergonomics
Field: Social Sciences
Domain: Social Sciences
Brazoide E, a New Alkaloid and Other Compounds from Justicia wasshauseniana (Acanthaceae)

A new alkaloid, named brazoide E (6), three known steroids (campesterol, β-sitosterol, stigmasterol), two glucosides (3-O-β-D-glucopyranosylsitosterol and 3-O-β-D-glucopyranosyl stigmasterol) and sucrose were isolated from the leaves and stems of Justicia wasshauseniana. Their structures were characterized using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (1D and 2D NMR), and infrared (IR) spectroscopy. To reinforce the structural proposal, an acetylated derivative (6a) was obtained and its data compared to 6. Moreover, circular dichroism spectroscopy (CD) analysis was performed to determine the absolute stereochemistry, time-dependent density functional theory (TD-DFT) at the wB97X-D/def2-TZVP level, adopting functionals M06-2X and wB97X-D and base aug-cc-pVDZ, was employed to confirm the CD analysis.

Topic: Natural product bioactivities and synthesis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Finite impulse response-median hybrid filtering techniques for image smoothing

By applying finite impulse response filtering in conjunction with a median operation, the edges as well as the fine details in the input image can be preserved. The finite impulse response-median hybrid filter thus obtained is computationally more efficient and preserves both details and edges better than conventional median filters. The optical implementation of such a hybrid filter is discussed in this paper.

Topic: Image Processing Techniques and Applications
Subfield: Media Technology
Field: Engineering
Domain: Physical Sciences
HIV Triggers Interleukin 21-Mediated Induction of Granzyme B-Secreting B Cells with Regulatory and Antiviral Potential

Abstract Abstract 1042 Certain regulatory lymphocyte subpopulations including plasmacytoid dendritic cells and regulatory T cells secrete granzyme B (GrB), thereby suppressing T cell expansion. Recently, we found that B cells can also produce GrB and acquire regulatory potential in response to interleukin (IL-)21. Since HIV has been shown to be associated with elevated serum IL-21 levels, we hypothesized that GrB-expressing B cells may be induced during HIV infection. Here, we show that infection of CD4+ T cells with HIV 1 (NL4-3), but not mock infection, induces strong expression of IL-21 without upregulation of CD40 ligand. Importantly, we further demonstrate that such IL-21+CD40Llow T cells induce GrB in cocultured B cells in an IL-21-dependent fashion, rather than supporting their differentiation into plasma cells. In support of these findings, serum levels of both IL-21 and GrB are significantly higher in HIV-infected patients before HAART as compared to healthy controls. Up to 60% of freshly isolated B cells (36.2% ± 12.9%) from patients infected with HIV, but not B cells isolated from healthy individuals, express GrB. Of note, coculture of HIV-infected CD4+ T cells with GrB+ B cells result in GrB transfer, and strongly suppresses both, proliferation of T cells and viral replication as indicated by significantly reduced p24 levels in coculture supernatants. The observed effects are enhanced by IL-21, and reduced by GrB inhibition. In summary, we demonstrate that HIV infection induces IL-21 in CD4+ T cells, thereby indirectly triggering the development of GrB-secreting B cells with antiretroviral properties. GrB-secreting B cells may play a so far unappreciated role in decelerating HIV expansion, particularly in the early phase of infection. On the other hand, induction of GrB in HIV-specific B cells may interfere with their terminal differentiation into plasma cells, which may explain the lack of an efficient anti-HIV humoral immune response in HIV-infected patients. Disclosures: No relevant conflicts of interest to declare.

Topic: Cytomegalovirus and herpesvirus research
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Defining the Heterogeneity of Anti-Tumor Antibody Responses

Abstract Studies were undertaken to analyze the humoral in vivo and in vitro antibody response of BALB/c mice to a syngeneic MSV-induced tumor cell line. With a sensitive radioimmunoassay, sera obtained from individual progress or and regressor mice were shown to vary greatly in total tumor-specific antibody concentration as well as immunoglobulin class distribution of the antibody, but no significant difference existed between the groups of progressor and regressor mice as a whole. In addition, serum antibodies from all animals were shown to have extensive cross-reactivity against a variety of cell lines chosen to share one or more antigens with the cell line used for immunization. Conversely, when in vitro fragment cultures of splenic tissue from progress or and regressor mice were stimulated with tumor-related antigen, differences in responsiveness among normal, progressor, and regressor mice were observed. In addition, antibodies derived from fragment cultures displayed several different cross-reactivity patterns all of which were more restricted in specificity than serum antibodies.

Topic: Immunotherapy and Immune Responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
CCDC 664516: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Error analysis in parallel-axes binocular stereoscopic measurement system caused by the calibrated parameters

This paper focuses on the errors in parallel-axes binocular stereoscopic measurement system caused by the calibrated parameters. The Monte-Carlo method was used in simulating and analyzing the errors. In the view of complex algebraic expression of 3D point from the positioning model of binocular vision, according to the independence of imaging-model-parameters, a method of single-parameter analysis of positioning errors was proposed to facilitate the simulation. The simulation results and experiments show that among the intrinsic parameters, the calibration error of the principle point (u0, v0) has a significant influence on the positioning accuracy on the X and Y direction, and the calibration error of focus f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> has an obvious influence on the positioning accuracy on the Z direction. On the other hand, among the extrinsic parameters, both the rotation angle β and the baseline t1 have a visible influence on the positioning accuracies accuracy on all the three directions. The conclusion can be taken as a reference for the design and calibration of binocular vision system.

Topic: Optical measurement and interference techniques
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences