jimnoneill/paper-to-field-training huggingface dataset:
Antibiotic Resistance and Virulence Factors of Extended-Spectrum Beta-Lactamase-Producing Klebsiella Pneumoniae Involved in Healthcare-Associated Infections in Dakar, Senegal

Background: Virulent and resistant Klebsiella pneumoniae strains are considered as one of the most significant causes of healthcare-associated infections (HAIs). The aim of this study was to investigate the phenotypic and genotypic factors of antibiotic resistance and virulence factors of ESBL K. pneumoniae strains isolated from healthcare-associated infections (HAIs) in Dakar, Senegal. Methods: Twenty-eight strains of K. pneumoniae isolated from HAIs were collected from 2018 to 2021 in 2 main hospitals in Dakar. Antibiotic susceptibility and molecular characterization were studied using disk diffusion by the Kirby-Bauer method and PCR, respectively. Virulence factors were also determined by PCR. Results: These ESBL K. pneumoniae isolates showed high resistance to antibiotics such as bêta-lactams, aminoglycosides, cyclins, fluoroquinolones and trimethoprim-sulfamethoxazole. Among these strains, ten (10) were resistant to carbapenem and cefoxitin (17.8%, n=5), chloramphenicol (25%, n=7) and fosfomycin (28.5%, n=8) considered as the most active antibiotics against ESBL-KP isolates. Eighteen (18) strains were considered as MDR and ten (10) strains as XDR. For the genes associated to phenotypic resistance, bêta-lactams resistance was conferred through bla SHV (24/28), bla TEM (20/28) and mainly by blaCTX-M. All strains carried the blaCTX-M15 gene. OXA-48 (6/28) gene was found responsible for carbapenem resistance and other genes like IMP, VIM, NDM, OXA-23 were not detected. Plasmids-mediated resistance genes qnrB (16/28), qnrS (11/28) and aac(6')-Ib (21/28), were mostly responsible for resistance to fluoroquinolones and aminoglycosides. Also 3 of 6 virulence genes searched that are the most associated to the pathogenicity of Klebsiella pneumoniae were found on these strains with uge (19/28), mrKD (21/28) and fyuA (13/28). Conclusion: The ESBL K. pneumoniae strains isolated in this study showed a high prevalence of antibiotic resistance and virulence genes The combination of these factors poses a potential risk for infections that could be highly virulent and difficult to treat. These findings demonstrated the importance of closely monitoring the resistance patterns of K. pneumoniae in hospitals seetings and emphasize the need to monitor effective antibiotic treatments for K. pneumoniae infections. Aditionnally, the scarcity of available data on HAIs, especially the prevalence of Multidrug resistance bacteria and virulence factors associated with these HAIs in Senegal, further emphasizes the significance of implementing surveillance programs to better know their prevalence, impact on patient health and on length of hospital stays.

Topic: Antibiotic Resistance in Bacteria
Subfield: Molecular Medicine
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
"Once again on Preliminary Reference Earth Model"

Deformation properties of solid bodies required to study the data within thermobaric conditions of the Earth's core have been outlined Birch's diagrams of nonlinearly deformed media are constructed using nonclassical linearized approach The "key" of geomechanical analysis that considers specification of deformation process of solid bodies has been offered.

Topic: Geophysics and Gravity Measurements
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Analysis of a teacher training process through the study of educational interaction

The purpose of the study is to describe and analyse the configuration of joint activity in a teacher’s training process from a teaching and learning sociocultural perspective. From this theoretical perspective, formal learning is conceived as a mediated social construction process of meanings around learning content, and teaching as a process of planned, systematic and sustained support for that construction process. Taking this into consideration, an assessment course was video recorded to analyse the interaction between teachers and students undertaking this course. The findings describe how mechanisms of educational influence emerge in the form of assessment situations, specifically as instances of correction and feedback of the assessment results. The findings make it possible to visualise the way in which these training processes of university teachers are structured and the need to expand the research to the analysis of the interaction. This raises the need to consider the teaching of assessment as a complex process that acknowledges different situations that could be favouring self-regulation, beyond teaching a set of criteria, techniques and strategies to assess learning.

Topic: Education and Teacher Training
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
CoeusAI QGIS plugin - Efficient exploratory search for features

Our QGIS plugin, CoeusAI, is designed for exploration of multiband geospatial datasets. It lets the user iteratively train and retrain classification models in seconds. Traditional machine learning approaches can lack intelligent predictions, while deep neural nets typically require vast amounts of training data and compute. Our tool combines a pretrained UNet for feature extraction with a RandomForest for classification. We therefore leverage strong points of both. The use of a UNet makes it possible to take into account complex patterns and encode these in a feature space. The RandomForest is then trained on top of those features with little labeled data, and only seconds (or minutes) of compute time required. This allows for an interactive and explorative user experience. CoeusAI uses the functionalities of the command-line-tool and Python package, Pycoeus, it's main dependency, and makes them available with a user-friendly graphical user-interface to use in QGIS.

Topic: Cancer Treatment and Pharmacology
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Our experience in first 100 cases of endoscopic carpal tunnel release: An Indian perspective

This study was done to determine the role of endoscopic carpal tunnel release in the treatment of carpal tunnel syndrome and also to note the conversion rates of endoscopic to open release, causes for conversion and to analyse the learning curve of the operating surgeon for endoscopic procedure. A total of 100 consecutive idiopathic carpal tunnel cases were included who had undergone preoperative ultrasonography (USG) for assessment of carpal tunnel morphology. All patients were primarily scheduled for a standard single portal endoscopic release after excluding the contraindications for endoscopic carpal tunnel release (ECTR). The conversion rate of endoscopic to open carpal tunnel release (OCTR) was analysed and reasons for conversion were established by an independent observer. Out of 100 patients, 74 (74%) underwent endoscopic release and 26(26%) underwent mini-open release. The conversion rates from endoscopy to open was noted to be 26%. Distal edge not being visualized in 14 cases (53%) was the most common cause for conversion followed by tight canal hindering the insertion of the scope in four cases (15.3%). In the first fifty cases in our study, 20 cases were converted to open release which amounted to 40% conversion rate, but in the next 50 subset of patients the conversion rates had dropped to 13.3%. Endoscopic carpal tunnel release can be accepted as the treatment of choice for the surgical decompression of carpal tunnel owing to decreased postoperative complications. One of the major limitations of the ECTR is the slow learning curve of a surgeon. Difficulty to visualise the distal edge of TCL was most common cause for conversion. With increasing experience of a surgeon in endoscopic release, the conversion rates would decrease. Level of study: level 4, decision analysis

Topic: Peripheral Nerve Disorders
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Colour gradients of low-redshift galaxies in the DESI Legacy Imaging Survey

ABSTRACT Radial colour gradients within galaxies arise from gradients of stellar age, metallicity, and dust reddening. Large samples of colour gradients from wide-area imaging surveys can complement smaller integral-field spectroscopy data sets and can be used to constrain galaxy formation models. Here, we measure colour gradients for low-redshift galaxies (z &amp;lt; 0.1) using photometry from the DESI Legacy Imaging Survey DR9. Our sample comprises ∼93 000 galaxies with spectroscopic redshifts and ∼574 000 galaxies with photometric redshifts. We focus on gradients across a radial range 0.5Reff to Reff, which corresponds to the inner disc of typical late-type systems at low redshift. This region has been the focus of previous statistical studies of colour gradients and has recently been explored by spectroscopic surveys such as MaNGA. We find that the colour gradients of most galaxies in our sample are negative (redder towards the centre), consistent with the literature. We investigate empirical relationships between colour gradient, average g − r and r − z colour, Mr, M⋆, and sSFR. Trends of gradient strength with Mr (M⋆) show an inflection around Mr ∼ −21 ($\log _{10} \, M_\star /\mathrm{M_\odot }\sim 10.5$). Below this mass, colour gradients become steeper with increasing M⋆, whereas colour gradients in more massive galaxies become shallower. We find that positive gradients (bluer stars at smaller radii) are typical for galaxies of $M_{\star }\sim 10^{8}\, \mathrm{M_\odot }$. We compare our results to age and metallicity gradients in two data sets derived from fits of different stellar population libraries to MaNGA spectra, but find no clear consensus explanation for the trends we observe. Both MaNGA data sets seem to imply a significant contribution from dust reddening, in particular, to explain the flatness of colour gradients along the red sequence.

Topic: Galaxies: Formation, Evolution, Phenomena
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Effects of lower-body negative pressure on sympathetic nerve responses to static exercise in humans. Microneurographic evidence against cardiac baroreflex modulation of the exercise pressor reflex.

Although previous studies in both animals and humans have suggested that cardiac baroreceptors modulate reflex sympathetic vasoconstriction during exercise, more recent studies in conscious animals have not supported this view. To further test this concept in humans, we measured sympathetic nerve discharge with intraneural microelectrodes while we used static handgrip to activate the exercise pressor reflex and nonhypotensive lower-body negative pressure (LBNP) to selectively unload the cardiac baroreflex. In nine healthy subjects, we measured blood pressure, heart rate, central venous pressure, and muscle sympathetic nerve activity (MSNA) from the peroneal nerve (resting leg) during 2 minutes of static handgrip at 20% and 30% of maximal voluntary contraction (MVC) alone and in combination with LBNP at -5 mm Hg. Handgrip alone (exercise reflex) at 20% and 30% MVC caused graded increases in MSNA. LBNP alone (cardiac reflex) did not alter blood pressure or heart rate but decreased central venous pressure by 2.5 +/- 0.1 mm Hg (mean +/- SEM, p less than 0.05) and increased MSNA by 92 +/- 22% over the control value. Most important, handgrip performed during LBNP (interaction of reflexes) caused increases in MSNA that were comparable with the increases during handgrip alone: +114 +/- 32% versus +175 +/- 89% at 20% MVC and +328 +/- 101% versus +431 +/- 110% at 30% MVC (handgrip plus LBNP vs. handgrip alone, p greater than 0.1). Pressor and heart rate responses to handgrip also were unaffected by LBNP. In five additional experiments, comparable findings were obtained when the LBNP was superimposed on handgrip rather than handgrip being superimposed on LBNP. In conclusion, this study provides direct evidence in humans that nonhypotensive LBNP does not augment muscle sympathetic outflow during static handgrip and challenges the concept of an important interaction between cardiac baroreceptor and exercise pressor reflexes during this form of exercise.

Topic: Heart Rate Variability and Autonomic Control
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Punk and metal: antithesis, synthesis or prosthetic?

On the surface of it punk and metal are as alike as chalk and cheese. Metal is the cult of the guitar hero - punk, the anti-guitar hero. Metal admires technique, virtuosity and composition. Punk: amateurism, spontaneity, chaos. Likewise, subcultural stylization: long hair, the ‘poodle perm’ or the mullet-cut vs. the Mohican, spiky-mop or skinhead crop; boys behaving badly vs. boys (and sometimes girls) behaving politically; Teutonic runes vs. ‘ransom’ style, cut-ups and paste; Armageddon vs. anarchy; punk’s social realism vs. metal’s comic-book iconography; and so on and so forth. While such a caricatured list is, on one level absurd, it speaks of a real and deeply felt sense of difference and antagonism between the musical movements and subcultures; one which raged at its most fierce during the rise and demise of U.S. post-punk and hardcore (1978-1985), UK punk (1975-78) and Oi/Street/ Anarcho and Post-punk (1979-84) scenes, respectively. &#13;\nWhile there are plenty of examples of hostility and incomprehension from individual musicians, bands, subcultural members, fans and fanzine editors, as well as professional music critics and academics, suggesting that punk and metal have nothing in common - never had and never could have - it is my contention that whether metallers and punks like it or not their musical styles and subcultures, cross and re-cross each other in a complex, genre-expanding and cross-pollinating fashion (from at least 1978 onwards). What is less appreciated is that this cultural syncretism is merely the most visible and dramatic example of a largely unexplored history of musical, (sub)cultural and political borrowings, appropriations and adaptations, which define and re-define the borders of punk, hardcore and metal. &#13;\nMy paper offers a framework for interpreting this border politics in terms of the concepts of antithesis, synthesis and prostheticization. It asks how the musical and cultural relations between punk and metal can be characterized at various points in their evolution? This involves a consideration of musical and performance style, subcultural scene and economic substructure (recording, distribution and promotion) and the extent to which an examination of the emergence of particular styles reveal ‘moments’ of clear opposition, signs of integration or major (largely unacknowledged) ‘surgery’ that has benefited the one at the expense of the other. On balance it is metal that has borrowed most from punk but in the course of this osmosis punk has itself become subject to internal claims and antagonisms over difference and definition that have themselves involved the currency of metal.

Topic: Music History and Culture
Subfield: Music
Field: Arts and Humanities
Domain: Social Sciences
Exploring combinations of dimensionality reduction, transfer learning, and regularization methods for predicting binary phenotypes with transcriptomic data

This repository contains supplementary materials for the research paper "Exploring combinations of dimensionality reduction, transfer learning, and regularization methods for predicting binary phenotypes with transcriptomic data." The materials are organized into two distinct folders: - supplementary_code: source code to reproduce the analysis<br> AE network training<br> AVAE network training<br> phenotype data collection<br> predictive modeling pipeline - supplementary_data: networks and datasets used in this study<br> 01: trained AE network<br> 02: trained AVAE network<br> 03: trained c-ICA network<br> 04: 30 transcriptomic datasets with all representations and phenotypes<br> 05: dataset predictive performances and significance<br> 06: robustness analysis<br>

Topic: Gene expression and cancer classification
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Gilligan’s Persfective Morality Toward Women in Short Stories Which Published in Kompas From 2010-2015

This research focuses on Giligan’s morallity concept that relate to three aspects of woman’s attitude which include pre-conventional (individualist), conventional (willing to sacrifice), and pasca-conventional (determine of decision). This research used content analysis method. There were 23 of 130 short stories from Kompas that taken as data of this research. The result of this research indicates that individualist of woman attitude is caused by her ego, safety, and anxiety. Willing of sacrife attitude is caused by pity and carinng; determine of decision is caused by cause and effect relationship which support by guilty, happiness, doubt, tough, hopeless, and desperate.&#x0D; &#x0D; Keywords: morality, Gilligan, women, short stories, kompas&#x0D; &#x0D; Abstrak&#x0D; Penelitian ini berfokus pada moralitas Gilligan mengenai tiga aspek sikap perempuan yaitu prakonvensional (individualis), konv­ensional (rela berkorban), pascakonvensional (penentuan keputusan). Metode penelitian menggunakan analisis isi. Data yang dianalisis dari Kompas berjumlah 23 dari 130 cerpen tahun 2010-2015. Hasil penelitian menunjukkan sikap individualis perempuan disebabkan oleh kepentingan sendiri, rasa aman, dan khawatir. Sikap berkorban disebabkan oleh rasa iba dan kasih sayang; penentuan keputusan disebabkan oleh hubungan timbal balik dengan disertai rasa sesal, bahagia, bimbang, yakin, putus asa, dan pasrah.&#x0D; &#x0D; Kata kunci: moralitas, Gilligan, perempuan, cerita pendek, kompas&#x0D;

Topic: Linguistics and Language Analysis
Subfield: Language and Linguistics
Field: Arts and Humanities
Domain: Social Sciences
Peer Review #1 of "Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma (v0.1)"

Background: Differently expressed circular RNAs (circRNAs) have been reported to play a considerable role in tumor behavior; however, the expression profile and biological function of circRNAs in papillary thyroid carcinoma (PTC) remains unknown.Thus, the study was aimed to characterize the circRNA expression profile to comprehensively understand the biological behavior of PTC.Methods : We investigated the expression profile of circRNAs using circRNA microarray in three pairs of PTC and adjacent normal tissues.Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate eight candidate circRNAs in 40 paired PTC tumors and adjacent normal samples.Next, we employed a bioinformatics tool to identify putative miRNA and circRNA-associated downstream genes, followed by constructing a network map of circRNA-miRNA-mRNA interactions and exploring the potential role of the candidate circRNAs.Results: In total, 206 up-and 177 downregulated circRNAs were identified in PTC tissues (fold change >1.5; P< 0.05).The expression levels of eight candidate circRNAs confirmed by qRT-PCR were significantly different between the PTC and normal samples.The downstream genes of candidate circRNAs participated in various biological processes and signaling pathways.The most up and downregulated circRNAs were hsa_circRNA_007148 and hsa_circRNA_047771.The lower expression level of hsa_circRNA_047771 was associated BRAFV600 mutation, lymph node metastasis (LNM), as well as with advanced TNM stage (all P<0.05).The higher expression level of hsa_circRNA_007148 was significantly correlated with LNM (P< 0.05).The areas under receiver operating curve were 0.876 (95% CI, 0.78-0.94)for hsa_circRNA_047771 and 0.846 (95% CI, 0.75-0.96)for hsa_circRNA_007148.Discussion: The study suggests that dysregulated circRNAs play a critical role in PTC pathogenesis.PTC-related hsa_circRNA_047771 and hsa_circRNA_007148 may serve as potential diagnostic biomarkers and prognostic predictors for PTC patients.

Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The benefits of learning english to students of West Kazakhstan Marat Ospanov Medical University

English language becomes really in demand in human activities. It becomes a real factor of socio-economic, scientific, technical and cultural progress. Now, knowledge of English is a compulsory requirement for employment, and the field of medicine has not become an exception. Our university supports the expression of the head of the Republic of Kazakhstan that today’s generation have to learn three languages, especially English which is language of advancement and technology. That’s why in this article the information is given about the opportunities which gives university to the students leaning English. International cooperation and academic mobility is one of the most important activities direction of the university. West Kazakshtan Marat Ospanov Medical University has a department for the implementation of trilingual education. The main functions of the department for the implementation of trilingual education are given in this work. Also this year our university decided to provide students with lessons preparing for IELTS and IELTS certificates. IELTS is the most popular English language test in the world. In this scientific work interview was conducted among students and the results of it were indicated. English is important, but some of students were not agree with this statement and they also added that it is not necessary to learn English for medical students. After the conducted research it is possible to tell with confidence, that students of medical university understand importance of knowledge of foreign languages in the future profession. And they learn foreign languages, not only because it is one of the main subjects of instruction, but also on their own initiative, and they also intend to further improve their knowledge.

Topic: Second Language Learning and Teaching
Subfield: Literature and Literary Theory
Field: Arts and Humanities
Domain: Social Sciences
Mechanical Thrombectomy for Acute Ischemic Stroke

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal

Topic: Acute Ischemic Stroke Management
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences