jimnoneill/paper-to-field-training huggingface dataset:
Improved Sway Velocities and Directional Balance Improvement in Two Individuals with Spinal Cerebellar Ataxia with Balance-Based Torso-Weighting: A Case Series Report (P2.130)

OBJECTIVE: To determine immediate and short-term impact of the application of Balance-Based Torso-Weighting (BBTW) and BalanceWear® Therapy (BWT) on sway patterns in spinocerebellar ataxia (SCA).
BACKGROUND: Individuals with SCA exhibit impairments in balance and mobility often resulting in falls. BBTW demonstrated immediate improvement in gait and balance in recent MS studies. BWT involves the patient wearing BalanceWear®; weights are strategically placed to augment sensory information.
DESIGN/METHOD: Sway velocity, direction, and magnitude were measured with ADPM, Inc.™, sensors placed posteriorly at the lumbosacral junction before and after BBTW immediately and after three or five days of BWT with two individuals with midline cerebellar atrophy confirmed by MRI.
PRIMARY OUTCOME MEASURES: Sway
RESULTS:
In Patient 1, a 72 year old woman with a 6 year history of a slowly progressive, idiopathic, cerebellar syndrome composite scores (CS) of sway velocity improved from 98 to 71 m/s from pre-BBTW to post-BBTW same session. Lower scores indicate less sway. Patient 1 wore BWT 10 hours each day for four days. On day 5 she was retested without BWT. Her CS was reduced from 98 to 68 m/s. Her directional imbalance improved.
In Patient 2, a 46 year old woman with a 12 year history of a slowly progressive cerebellar syndrome with upper motor neuron features CS was reduced from 95 to 49 m/s immediately from pre-BBTW to post-BBTW. Patient 2 wore the BWT for 18 hours over two days and was retested 15 hours after BWT. On day three; her CS was reduced from 95 to 24 m/s and direction of sway improved.
CONCLUSION: Application of BBTW and BWT may be beneficial in reducing sway and improving directional instability in patients with SCA. More research is indicated in this patient population, where minimal information is available for symptom management of falls and mobility challenges. Disclosure: Dr. Gibson-Horn holds stock and/or stock options in Motion Therapeutics. Dr. Perlman has received research support from Santhera Pharmaceuticals.

Topic: Genetic Neurodegenerative Diseases
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Levitated liquid hydrogen cryotank for automotive applications

A critical component for the application of hydrogen technology in automobiles is the storage of liquid hydrogen. Conventional tanks show intolerable evaporation losses. An innovative tank concept based on a superconducting suspension of an inner tank in an outer tank was realized in a functional model. The model shows an evaporation rate lowered by 50% compared to a conventional reference tank. In addition the design of a more compact prototype tank was worked out with a rotational symmetric arrangement. First components for this suspension concept were tested successfully. (author)

Topic: Spacecraft and Cryogenic Technologies
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
The Factor Structure of Preschool Learning Behaviors Scale Scores in Peruvian Children

The factor structure of the Escala de Conductas de Aprendizaje Preescolar (ECAP), a Spanish translation of the Preschool Learning Behaviors Scale (PLBS), was examined in this study. Children aged 2 to 6 years ( N = 328) enrolled in public and private preschools in the Republic of Peru were rated by classroom teachers on the frequency of observable, learning-related behaviors using the ECAP. Exploratory factor analyses identified three underlying dimensions of the scale: competence motivation, effortful strategy/flexibility, and attention. The three factor scores exhibited internal reliability coefficients above .70, and the alpha was .92 for the total score.

Topic: Early Childhood Education and Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
The influence of growth conditions on the susceptibility of Mycobacterium tuberculosis to antibiotics

Mycobacterium tuberculosis is the causative agent of tuberculosis disease which is a global health emergency. Lengthy treatment is required due to the intrinsic resistance of M. tuberculosis to most classes of antibiotics and continued survival of drug tolerant persisting populations. This tolerance and persistence may be because of pre-existing populations of bacteria recalcitrant to treatment through phenotypic mechanisms such as slow growth or nonreplicating persistence; or through genotypic alterations resulting in resistance phenotypes. In order to improve treatment, effective in vitro modelling of these populations and factors affecting efficacy is essential. Cell density, growth rate and growth phase were all found to affect the efficacy of isoniazid and rifampicin in this study. M. tuberculosis grown at a high cell density was shown to be less susceptible to antibiotic exposure, this was particularly true for rifampicin. Growth phase was also considered, in the host, a bacterium is likely to encounter nutrient depletion and enter stationary and non-replicating phases. Isoniazid and rifampicin were both less effective the longer M. tuberculosis was in culture. This work demonstrated the need for consideration of multiple factors when designing and modelling treatment of tuberculosis. Using continuous culture M. tuberculosis was grown at a fast (23.1 hours) and slow (69.3) doubling times, with and without isoniazid exposure aiming to elucidate the different responses these populations may have to antibiotic. Genotypic analyses showed that slow growing bacilli developed resistance to isoniazid through mutations specifically in katG codon Ser315 which are present in approximately 50–90% of all isoniazid-resistant clinical isolates. The fast growing bacilli persisted as a mixed population with katG mutations distributed throughout the gene. Phenotypic differences were detected between the populations at the two growth rates including expression of efflux mechanisms and the involvement of antisense RNA/small RNA in the regulation of a drug-tolerant phenotype.

Topic: Tuberculosis Research and Epidemiology
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
EFFECT OF SAVORY EXTRACT SUPPLEMENTATION ON SOME PRODUCTIVE TRAITS AND ECONOMIC EFFICIENCY OF COMMON CARP (Cyprinus carpio L.)

The purpose of this study is to evaluate the effectof a dietary savory extract supplement on the survival rate, growthperformance, feed conversion ratio and economic efficiency of common carp (Cyprinus carpio L.) reared in arecirculation system. Thirty-two carps were allotted into two experimentalvariants, each of them comprising two replications with 8 fish in a group. Theaverage initial live weight of fish from both replications from the controlgroup (CG) and experimental group (EG) was 866.56±113.99 g and 866.81±119.10 g,respectively (p&amp;amp;gt;0.05). They were kept in concrete tanks with efficient watervolume of 0.8 m3, elements of the recirculation system. Carps werefed pelleted carp feed with 25% crude protein, produced with pellet size of 6mm. The feed of fish from the EG was supplemented with 1% powdered savoryextract, after lubricating the pellets with 5 ml sunflower oil per 100 g feed.Control carp received the same amount of sunflower oil-lubricated feed. Thedaily ration of fish from both replications was 1.8% of their live weight. Theexperiment duration was 45 days. Survival rates during the experiment showed 100% survival in carps, supplemented with 1% savory extractas well as in control fish. The average individual weight gain of carps from the two EG replications (supplemented with1% savory extract) was154.63±28.39 g, which was higher than that of controls by 57.18% (Table 3), as thedifferences were statistically significant (p&amp;amp;lt;0.001). At the end of the trial, theanalysis of consumed feed amount showed that feed conversion ratio in the groupsupplemented with 1% savory extract was 2.25±0.43 e.g. by 67.11% lower thanthat of control group, as the differences were statistically significant(p&amp;amp;lt;0.001). The group that received 1% savory extract exhibited bettereconomic conversion ratio (1.98), by 42.42% lower than that of thenon-supplemented group.

Topic: Aquaculture Nutrition and Growth
Subfield: Aquatic Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Successful Treatment with Clonazepam and Pramipexole of a Patient with Sleep-Related Eating Disorder Associated with Restless Legs Syndrome: A Case Report

Sleep-related eating disorder (SRED) is characterized by recurrent episodes of involuntary eating during sleep period and is often associated with restless legs syndrome (RLS). Although pharmacotherapy is recommended for SRED patients, no drug have shown promising effects so far. The patient, a 48-year-old Japanese housewife, first visited our clinic and complained about nighttime eating. She had a history of hypertension, diabetes mellitus, sleep apnea syndrome, and depression. Insomnia appeared 10 years before the first visit and she often received hypnosedatives; at the same time, she developed nocturnal eating episodes. She had amnesia for these episodes, and she felt urge to move her legs while sleeping. The patient was diagnosed with SRED and RLS. Reduction in the doses of triazolam decreased her nighttime eating frequency, and her complete amnesia changed to vague recall of eating during night. Clonazepam 1.0 mg at bedtime decreased nocturnal eating frequency from 1 to 2 times per month, though sleepwalking remained. Administration of pramipexole 0.125 mg relieved all symptoms including SRED, RLS, and sleepwalking. This is the first paper to report that the combination of clonazepam and pramipexole therapy-reduced SRED episodes and RLS symptoms.

Topic: Restless Legs Syndrome Research
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Segregative Interactions in Single-Phase Mixtures of Gelling (Potato) Maltodextrin with Other Hydrocolloids

Potato maltodextrin (Paselli Excel; DE < 3) was used at a fixed concentration of 15 wt %. On holding at 5°C after rapid quenching from 45°C the onset of conversion from disordered coils to aggregated double helices was seen as a steep increase in turbidity (monitored by absorbance at 600 nm) after ∼50 min, and gelation was observed (visually) after ∼120 min. Incorporation of increasing concentrations of gum arabic (1, 2, 4 and 8 wt %) caused a large, progressive decrease in the time required for structure formation and gelation to occur. A similar massive increase in rate of self-association of maltodextrin was observed for mixtures with the same concentrations (1, 2, 4 and 8 wt %) of hydroxypropylmethylcellulose (HPMC). Unlike gum arabic, however, HPMC caused very large increases in the values of turbidity recorded immediately after quenching. This cannot be attributed to phase separation, since the mixtures did not resolve into two liquid layers on high-speed centrifugation, or to ordering of maltodextrin, which was seen as a sharp increase in turbidity at longer times. Our interpretation is that segregative interactions with disordered maltodextrin promote hydrophobic association of HPMC at temperatures where it would normally remain un-associated, in the same way as HPMC and gum Arabic promote self-association of maltodextrin. These conclusions accord well with a previous investigation which showed massive precipitation of low-DE potato maltodextrin from single-phase mixtures with disordered gelatin.

Topic: Polysaccharides Composition and Applications
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Development of Indigenous Alkaline Phosphatase Kit for the Detection of Milk Quality

Milk is a profoundly nutritious food that provides the favorable environment and nutrition for the growth development of large number of microorganisms. Microbiological quality assurance techniques could be usually utilized as a speedy strategy to survey the microbiological nature of crude and pasteurized milk. Objective: To develop indigenous rapid kit for determination and differentiation of milk quality, microbial presence, pasteurized and unpasteurized milk. Methods: Some 14-milk raw and pasteurized milk samples were collected from different geographical areas of Lahore and different brands of pasteurized milk. The colorimetric indigenous alkaline phosphatase milk quality detection kit was prepared for 200 reactions was developed. Alkaline phosphatase kit was tested at different temperature and volume of milk. Results: Results showed that a wide range of milk that bought from local stores and nearby market with exorbitant cost milk types shown no difference in milk quality in terms of presence of microbes. Moreover, different effect of pasteurized milk was observed after affirm test the variety stayed blue and not changed. Conclusions: This indigenous kit is test is quick monetary strategy that can be utilized for identification of milk quality on the basis of microbial presence, therefore, pasteurized or unpasteurized milk can be tested in field as well.

Topic: Milk Quality and Mastitis in Dairy Cows
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[Primary esophageal small-cell carcinoma].

Campared with ESCC and PEAC, PESC is the most malignent one with early lymphatic and hematogenous matastases and poor prognosis. Lymph node metastasis is the major factor influencing prognosis. Patients in stage 0, I and II a of PESC are indicated for surgical resection, while those in stage II b, III and IV should be managed with non-surgical combined therapy.

Topic: Neuroendocrine Tumor Research Advances
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
LHD nb2pwr_PortThrough #178998.1 (analyzed)

Neutral beam injector (NBI) power-PortThrough of beam line 2 (BL2). The effective power that actually reaches the plasma after the negative ion-based neutral particle beam emitted from the NBI system passes through BL2.

Topic: Trauma and Emergency Care Studies
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
[The role of adenine nucleotide catabolism in the interphase death of thymocytes, caused by papaverine and dipyridamole].

Papaverine and dipyridamole induce the interphase death of thymocytes rapidly growing four hours later and reaching its maximum by the seventh-eighth hour of the cell incubation. To induce death of thymocytes no constant presence of these preparations in the incubation medium is needed, a definite (for each of preparations) time of the contact with cells being enough. The interphase death of thymocytes induced by papaverine and dipyridamole is preceded by acceleration of the release of adenine nucleotide catabolism products from cells mainly as hypoxanthine and inosine, respectively. These both processes are induced by papaverine for a shorter period of its incubation with cells than by dipyridamole and the joined use of these substances intensifies the above processes. The analysis of the data obtained indicates that thymocytes under the effect of papaverine die rather from the exhaustion of the adenine nucleotide pool, than from a decrease in the adenylate charge of cells. Exogenous adenosine essentially removes the toxic effect of papaverine but not of dipyridamole. Addition of adenine and inosine to thymocytes does not affect their survival rate in the presence of the preparations under study.

Topic: Chemical Reactions and Isotopes
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Queer at 25: A Critical Perspective on Queerness, Politics and Futures

With a focus on contemporary South Africa, and through the lens of queer identity and politics, the article critiques the limitations and possibilities for queerness and its futures in post-apartheid South Africa. From the advent of constitutional democracy and its ushering in of human rights, the article analyses developments in the politics of sexuality in the context of enduring systems of violence, rooted in colonial and apartheid histories. Discrimination against lesbian, gay, bisexual, transgender and intersex people – at the intersection with other forms of discrimination – has emerged as a focal point for political resistances in the post-apartheid period. These resistances are interrogated, including the paradoxes of rights struggles that they expose, and the contradictions between formal equality gains and present queer realities that they call attention to. With an emphasis on enduring inequalities within post-apartheid society, and on the racialisation of violence against queerness, the article explores various political formations of and for queer freedom. In navigating these dynamics of inequality and difference, the article urges a radical politics – both for relating as equals, and against the violent ends of othering.

Topic: African Sexualities and LGBTQ+ Issues
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Frozen Section Intraoperatively is it Adequately Accurate in Endometrial Carcinoma Cases?

Background: Frozen section is one of the basic diagnostic tools implemented intraoperatively to elucidate the requirement of lymph node dissection, however diagnostic accuracy is a matter of debate among various research groups in oncological centers all over the globe. Methodology:A retrospective clinical research trial that recruited 90 research study subjects having endometrial carcinoma in which all recruited subjects Had histological grading and invasion level of muscular tissue planes assessed by usage of intraoperative frozen section investigative tool from February 2016 till January 2019. Results:The comparative analyses of the Risk of Lymph-Node Metastasis between the Preoperative, frozen section and Permanent-Section Diagnoses in the 90 Patients with Endometrial Carcinoma in which as regards preoperative diagnosis in comparison to permanent section diagnosis concerning low risk, intermediate risk, high risk, total accuracy was 57.69%, 50.00%, 53.33%, 53.3% consecutively ,whereas frozen section diagnosis accuracy as regards low risk, intermediate risk, high risk, total accuracy was 88.46%, 73.53%, 66.67%, 75.6% consecutively. Conclusions and recommendations:The current research study have shown the superiority of frozen section over MRI and various perioperative assessment tools in evaluating accurately invasiveness, grade and lymph node disease ,however the current research study findings should be interpreted with caution as other modes for diagnosis are gaining privilege over cosurgical practice such as sentinel lymph node mapping.

Topic: Endometrial and Cervical Cancer Treatments
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
c‐Jun N‐terminal kinase 2 contributes to the tumorigenesis of non‐small cell lung carcinoma through MKK4‐dependent and MKK7‐independent mechanism

It had been reported previously that the JNKs require phosphorylation by both MKK4 and MKK7 to become activated. While the JNK2 isoform shows a unique propensity among the JNKs to autophosphorylate in vitro. Recent studies in glioblastoma and lung carcinoma have suggested important roles for constitutive activation of JNK2 (but not JNK1). Here we show that JNK2 autophosphorylation contributes to the proliferation of NSCLC cells under conditions of low serum through an MKK4‐dependent and MKK7‐independent mechanism. Using recombinant activated (MKK4 &amp; MKK7) and inactivated (JNK1 &amp; JNK2), we investigated the mechanism of JNK2 autophosphorylation and found that it has a strong preference to autophosphorylate on Thr‐183, while exhibiting a slower phosphorylation on Tyr‐185. This ability to efficiently autophosphorylate on Thr‐183 distinguishes it from other isoforms and facilitates its activation through a previously unknown mechanism involving MKK4. Phosphorylation of Tyr‐185 by MKK4 synergizes with Thr‐183 autophosphorylation to activate JNK2. Evidence in multiple cell lines including mouse embryonic stem cells lacking MKK4 or MKK7 suggests that autophosphorylation alone activates JNK2 weakly in cells. However, JNK2 autophosphorylates on Thr‐183, to create a pool of JNK2 primed for activation by MKK4, which phosphorylates JNK2 on Tyr‐185 to activate it. Under conditions of low serum JNK2, but not JNK1 exhibits a dose‐dependent dephosphorylation upon treatment of NSCLC cells with the pan‐JNK ATP competitive inhibitors (JNK‐IN‐8 and SP600125), further supporting the notion that active JNK2 results primarily from autophosphorylation of Thr‐183. Under similar conditions of low serum the MKK4‐JNK2 pathway but not MKK7 or JNK1 promotes proliferation of NSCLC through STAT3. This was further investigated in vivo using A549 Xenografts in which either JNK2 or MKK4 were stably knocked down. Taken together the data suggest that JNK2 autophosphorylation primes it for activation by MKK4. This pathway promotes the activation of c‐jun and the proliferation of NSCLC in vivo. Support or Funding Information Support by NIH (GM059802, GM106137, and CA167505), the Welch Foundation (F‐1390 and F‐1691), CPRIT (RP101501, RP140648, and RP140649)

Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Fatness and<i>Fable</i>: Regulating the Interactive Body in Video Games

The video game Fable 2 promises new modes of interaction, by which decisions made by the player can shape the game world and the body of their virtual persona. Some decisions affect the good/evil index by which the avatar takes on a diabolical or saintly aspect. Other decisions affect the character's purity/corruption index, which impacts on the relative thinness and upright posture or fatness and hunched posture and of the avatar. This moralisation of fatness, embedded in the ideological code of the game reflects a set of values about consumption, exploitation and the aesthetics of body. These ‘morality systems’ as they are described in video games are connected to the ways in which other characters respond to you, define the life choices and options (in the Fable games this includes marriage and children) and shape the metaphysical powers of your character. As interactive media evolves, and these kinds of complex interactions become more commonplace, we must challenge the design decisions that align meat eating, tenant exploitation, farting on angry people, bigamy, stealing, long periods of sleep and interpersonal meanness with a fat body image. We are increasingly using avatars as a form of virtual embodiment, particularly in social networking and the deployment of avatars in video games provides precedents for their use in other contexts.

Topic: Digital Games and Media
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences