jimnoneill/paper-to-field-training huggingface dataset:
I have a DRIHM: A Case Study in Lifting Computational Science Services Up to the Scientific Mainstream

While we are witnessing a transition from petascale to exascale computing, we experience, when teaching students and scientists to adopt distributed computing infrastructures for computational sciences, what Geoffrey A. Moore once coined the chasm between the visionaries in computational sciences and the early majority of scientific pragmatists. Using the EU-funded DRIHM project (Distributed Research Infrastructure for Hydro-Meteorology) as a case study, we see that innovative research infrastructures have difficulties to be accepted by the scientific pragmatists: The infrastructure services are not yet "mainstream". Excellence in workforces in computational sciences, however, can only be achieved if the tools are not only available but also used. In this paper we show for DRIHM how the chasm exhibits and how it can be crossed.

Topic: Scientific Computing and Data Management
Subfield: Information Systems and Management
Field: Decision Sciences
Domain: Social Sciences
Pengembangan Modul Pembelajaran Kontekstual disertai Concept Mapping pada Materi Elastisitas dan Hukum Hooke

This research aims to develop and determine the quality of the contextual learning module accompanied by a concept mapping of elasticity material andlaw Hooke in class XI IPA MA Mu'allimat NW Pancor students. This type of research is research and development. The method used in this research is 4-D method, which consists of the stages of define, design, development and dissemination. This research is limited to the stage, development namely the development test on a limited scale. The data in this study were analyzed descriptively qualitatively. The research subjects included 3 lecturers and 3 physics teachers as validators, and students of class XI IPA 1 MA Mu'allimat NW Pancor as respondents. The validation of lecturers and physics teachers both resulted in a score of 3.85 and the development trial on a limited scale resulted in a score of 3.88. All research results indicate that the module is feasible to be developed.

Topic: STEM Education
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
The Saga of Anthropology in China: From Malinowski to Moscow to Mao.. By Gregory Eliyu Guldin [Armonk: M. E. Sharpe,,1994xiv + 298 pp. 28 photographs. Hardcover, £44.00 ISBN 1-56324-185-4paperback £16.00, ISBN 1-56324-186-2.]

The Saga of Anthropology in China: From Malinowski to Moscow to Mao.. By Gregory Eliyu Guldin [Armonk: M. E. Sharpe,,1994xiv + 298 pp. 28 photographs. Hardcover, £44.00 ISBN 1-56324-185-4paperback £16.00, ISBN 1-56324-186-2.] - Volume 148

Topic: Chinese history and philosophy
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Harrison, Hon. Mr Justice William Henry, (25 Sept. 1880–18 July 1955), Judge Supreme Court of New Brunswick Appeal and Chancery Divisions since 1935; Past-President New Brunswick Command Canadian Legion BESL; Past-President St George’s Society and Canadian Club; Member of Senate, University of New Brunswick; Trustee, Beaverbrook Scholarships; Director NB Museum

"Harrison, Hon. Mr Justice William Henry, (25 Sept. 1880–18 July 1955), Judge Supreme Court of New Brunswick Appeal and Chancery Divisions since 1935; Past-President New Brunswick Command Canadian Legion BESL; Past-President St George’s Society and Canadian Club; Member of Senate, University of New Brunswick; Trustee, Beaverbrook Scholarships; Director NB Museum" published on by Oxford University Press.

Topic: Canadian Identity and History
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Radionecrosis (RN) in patients with brain metastases treated with stereotactic radiosurgery (SRS) and immunotherapy

Patients who received IT and SRS had acceptably low rates of RN. Timing of IT did not predict for RN. Further investigation is warranted to define RN risk with combined SRS and IT.

Topic: Brain Metastases and Treatment
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
ECONOMIC ASSESSMENT OF WATER HARVESTING PLUS SUPPLEMENTAL IRRIGATION FOR IMPROVING WATER PRODUCTIVITY OF A PULSE–COTTON BASED INTEGRATED FARMING SYSTEM IN TELANGANA, INDIA<sup>†</sup>

Abstract An integrated farming system (IFS) aims to sustain agricultural production, maintain farm incomes, safeguard the environment and respond to climate change impacts. Experiments in a tribal farmer's fields during 2016–2018 with two IFS models (pulse and cotton) were conducted in the Telangana region, India. An on‐farm reservoir (OFR) is designed for storing surface runoff based on the area and runoff coefficient determined through a modelling approach. The results demonstrated how supplemental irrigation and water harvesting are the most important and proven technologies for improving crop productivity and the efficient use of water in dryland areas of the semi‐arid tropics. The economic analysis indicated that after introduction of OFR technology, farmers' profits were increased under both scenarios of prolonged and short dry spells. According to the results, adoption of the OFR and IFS models not only ensured economic returns but provided regular employment even on less than 1 ha of land, which is usually non‐sustainable if monocropping is being practised. The approaches used in this work might be useful for guiding producers’ decisions in optimizing resources and selecting crops based on economic and water use efficiency. © 2020 John Wiley &amp; Sons, Ltd.

Topic: Irrigation Practices and Water Management
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Influence of ion-atom collisions on the recombination of electrons

The authors show that for the study of recombination of ions and electrons in weakly ionized low-temperature hydrogen plasmas, the processes H+H++e to H+H*(n) and H+2+e to H+H*(n) must both be considered since their contributions are comparable. A simple method for the calculation of the corresponding rate coefficients is presented.

Topic: Atomic and Molecular Physics
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
IMMU-34. ATRX MUTATIONS PREDICT RESPONSE TO INNATE BASED THERAPY IN GLIOMA

Abstract BACKGROUND Innate based immunotherapies are becoming increasingly important for treating brain tumor patients. Gliomas carry recurrent mutations in regulatory genes that control innate immune signaling responses. About 71% of adult WHO grade II and III gliomas and 57% of secondary glioblastomas also carry a loss-of-function mutation in the ATRX gene. ATRX is a SWI-SNF chromatin remodeling protein that has major roles in processes such as cell cycle regulation and maintenance of genomic stability. Recent studies have implicated ATRX in dysfunctional innate immune signaling in cancer cells. However, the role of ATRX in mediating innate immune responses has not been investigated in gliomas. METHODS AND RESULTS Human and mouse glioma cell lines from a variety of genetic contexts have been examined including models which carry IDH/ATRX mutations, IDH 1p-/19q- and ATRX -/- status. Additionally, using Crispr-Cas9 technology and cloning cell lines with ATRX deletions, we have derived a series of immune competent and nude mice models. Treating these cell lines with double-stranded RNA based innate stimuli led to an enhanced early induction in phospho-interferon regulatory factor 3 (IRF3) and late induction in phospho-STAT1 in the ATRX knockout (KO) cell lines. A differential increase in interferon-stimulated gene 15 (ISG15) release was also noted in the ATRX KO cell lines, further suggesting that ATRX deletion may enable a potent activation of type I interferon production. A combination of patient-derived glioma cell lines in xenograft models and syngeneic murine glioma models derived from ATRX KO cell lines and controls confirm a survival advantage in both immuno-competent mice and xenografts. Our models are under evaluation with PVSRIPO and other innate based RNA therapies. CONCLUSION Our data suggests that ATRX mutations may confer sensitivity to RNA-based innate immune signaling agonists in gliomas. This potential vulnerability can be targeted in future therapies.

Topic: interferon and immune responses
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Baker Chemicals

ADVERTISEMENT RETURN TO ISSUEArticleNEXTBaker ChemicalsCite this: Anal. Chem. 1952, 24, 7, 2APublication Date (Print):July 1, 1952Publication History Published online3 May 2012Published inissue 1 July 1952https://doi.org/10.1021/ac60067a700RIGHTS & PERMISSIONSArticle Views8Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (194 KB) Get e-Alerts Get e-Alerts

Topic: History and advancements in chemistry
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Supplementary Table S1 from A Novel &lt;i&gt;CDC25B&lt;/i&gt; Promoter–Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models

&lt;p&gt;Supplementary Table S1. CDC25B gene expression in different cell types&lt;/p&gt;

Topic: Cancer Research and Treatments
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Copy number variations: reliable diagnostic markers for Prader-Willi patients

Background Syndromic obesity is characterized by a specific set of associated clinical features, but the similarity between different obesity syndromes can make it hard to diagnose accurately. Prader-Willi syndrome (PWS) is the most common type of syndromic obesity. A variety of molecular and cytogenetic techniques may be needed for the diagnosis of obesity. Multiplex ligation-dependent probe amplification (MLPA) helps by allowing the study of multiple specific genetic regions at once. This makes it an effective screening tool for large groups of patients who may have deletions or duplications in specific genes. Objective We aim to establish a precise diagnostic scheme for early diagnosis that yields proper early intervention to prevent the development of morbid obesity and intellectual disability, which render a great burden on both health services and the families of the patients. Materials and methods Combined cytogenetic fluorescence in-situ hybridization and methylation studies using MLPA was conducted on 20 patients who were clinically suspected to have PWS. Results and conclusion We analyzed 20 suspected PWS cases descending from 18 unrelated families and 20 healthy controls matching age and sex, using MS-MLPA PWS/AS probemix (MRC-Holland) enables the identification of copy number variations or abnormal methylation patterns. One patient (P18) had PW deletion, which was evident by the reduced copy number ratio, and uniparental disomy was evident in two unrelated patients (P2 and P12). The results indicate that our study identified one typical PWS deletion and two uniparental disomy cases among three patients from distinct families, suggesting that atypical deletions are infrequent in this cohort. This research represents the first exploration of PWS in Egyptian patients using MLPA.

Topic: Genetic Syndromes and Imprinting
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Introduction

The Introduction sets the book in the context of current debates surrounding Employment and Support Allowance. It explains how concerns about how to assess incapacity for work for benefits purposes date back to the first National Insurance Sickness Benefits in 1911. The chapter begins with an exploration of a key legal case, the case of Mrs E from the 1950s. Mrs E's appeal to the National Insurance Commissioners, known as R(S)11/51, reflected many of the debates from the early twentieth century and provided the key case law for the next forty years. Her case illustrates many of the debates explored in the book. Over the last hundred years, debates about incapacity benefits have concerned disability, gender, the meaning of work and mechanisms for social control. This chapter introduces these concepts.

Topic: Social Policy and Reform Studies
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Large‐scale dynamics in colonization and extinction for breeding birds in Britain

1. A number of generalizations have been made as to the effects of the area of occupancy, population size, dispersal ability and body size of species on their relative rates of local colonization and extinction. 2. Here, data on the breeding bird assemblage of Britain are used to test these generalizations. The complete geographical ranges of British birds have been censused twice, in the periods 1968-72 and 1988-91, allowing rates of colonization and extinction between these periods to be estimated. 3. The local colonization dynamics of species are influenced independently by their range sizes and the dispersal abilities of adult birds: species with smaller range sizes and larger dispersal distances were more likely to have colonized new areas between the two census periods. 4. The local extinction dynamics of species are influenced independently by their population sizes and body masses: species with smaller population sizes and body sizes were more likely to have gone extinct from areas inhabited in the first census period. 5. These results remain when controlling for the effects of phylogenetic relatedness. 6. These analyses uphold many commonly held generalizations about the correlates of local colonization and extinction, and suggest that the long-term evolutionary history of these bird species has influenced their potential to respond to current ecological conditions.

Topic: Ecology and Vegetation Dynamics Studies
Subfield: Nature and Landscape Conservation
Field: Environmental Science
Domain: Physical Sciences
The global implications of the early surviving rock art of greater Southeast Asia

The rock art of Southeast Asia has been less thoroughly studied than that of Europe or Australia, and it has generally been considered to be more recent in origin. New dating evidence from Mainland and Island Southeast Asia, however, demonstrates that the earliest motifs (hand stencils and naturalistic animals) are of late Pleistocene age and as early as those of Europe. The similar form of the earliest painted motifs in Europe, Africa and Southeast Asia suggests that they are the product of a shared underlying behaviour, but the difference in context (rockshelters) indicates that experiences in deep caves cannot have been their inspiration.

Topic: Pleistocene-Era Hominins and Archaeology
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Towards Mechanistic Understanding of Steam Assisted Gravity Drainage in Naturally Fractured Reservoirs

Steam Assisted Gravity Drainage (SAGD) as a successful enhanced oil recovery (EOR) process has been applied to extract heavy and extra heavy oils. Huge amount of global heavy oil resources exists in carbonate reservoirs which are mostly naturally fractured reservoirs. Unlike clastic reservoirs, very few studies were carried out to determine the performance of SAGD in carbonate reservoirs. Even though SAGD is a highly promising technique, several uncertainties and unanswered questions still exist and they should be clarified for expansion of SAGD methods to world wide applications especially in naturally fractured reservoirs. In this communication, the effects of some operational and reservoir parameters on SAGD processes were investigated in a naturally fractured reservoir with oil wet rock using CMG-STARS thermal simulator. The purpose of this study was to investigate the role of fracture properties including fracture orientation, fracture spacing and fracture permeability on the SAGD performance in naturally fractured reservoirs. Moreover, one operational parameter was also studied; one new well configuration, staggered well pair was evaluated. Results indicated that fracture orientation influences steam expansion and oil production from the horizontal well pairs. It was also found that horizontal fractures have unfavorable effects on oil production, while vertical fractures increase the production rate for the horizontal well. Moreover, an increase in fracture spacing results in more oil production, because in higher fracture spacing model, steam will have more time to diffuse into matrices and heat up the entire reservoir. Furthermore, an increase in fracture permeability results in process enhancement and ultimate recovery improvement. Besides, diagonal change in the location of injection wells (staggered model) increases the recovery efficiency in long-term production plan.

Topic: Enhanced Oil Recovery Techniques
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Galactose Fermentation and Classification of Thermophilic Lactobacilli

The ability to ferment galactose is a major characteristic which can be used to differentiate Lactobacillus helveticus (galactose positive) from Lactobacillus lactis and Lactobacillus bulgaricus (galactose negative). In milk cultures, galactose-positive strains produced d - and l -lactic acid with little galactose accumulation, whereas galactose-negative strains produced d -lactic acid, and galactose accumulated to high levels.

Topic: Probiotics and Fermented Foods
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Peer Review #1 of "Rituximab increases the risk of hepatitis B virus reactivation in non-Hodgkin lymphoma patients who are hepatitis B surface antigen-positive or have resolved hepatitis B virus infection in a real-world setting: a retrospective study (v0.1)"

Background.Hepatitis B virus (HBV) reactivation with a hepatitis flare is a common complication in lymphoma patients treated with immunotherapy and/or chemotherapy.Anti-HBV prophylaxis is suggested for non-Hodgkin lymphoma (NHL) patients undergoing rituximab therapy, even those with resolved HBV infection.Since anti-HBV prophylaxis for patients with resolved HBV infection is not covered by national health insurance in Taiwan, a proportion of these patients receive no prophylaxis.In addition, late HBV reactivation has emerged as a new issue in recent reports, and no consensus has been reached for the optimal duration of anti-viral prophylaxis.Thus, the aim of our study was to investigate the incidence and outcomes of HBV reactivation in NHL patients in a real-world setting and to study the frequency of late HBV reactivation.Materials.NHL patients who received rituximab and/or chemotherapy at our institute between January 2011 and December 2015 and who were hepatitis B surface antigen (HBsAg)-or hepatitis B core antibody (HBcAb)-positive were reviewed retrospectively.Results.A total of 388 patients were screened between January 2011 and December 2015.In total, 196 patients were excluded because HBsAg was not assessed, HBcAb was negative or not assessed, or they were not treated with immunosuppressive therapy.Finally, the retrospective study included 62 HBsAgpositive NHL patients and 130 NHL patients with resolved HBV infection(HBsAg-negative and HBcAbpositive).During a median 30.5-month follow-up period, seven patients experienced HBV reactivation, five of whom had a hepatitis flare.The incidence of HBV reactivation did not significantly differ between the HBsAg-positive patients and the resolved HBV infection population without anti-HBV prophylaxis(4.8% vs. 3.1%, P=0.683).All patients with HBV reactivation were exposed to rituximab.Notably, late HBV reactivation was not uncommon (two of seven patients with HBV reactivation events, 28.6%).HBV reactivation did not influence the patients' overall survival.An age ≥65 years and an advanced disease stage were independent risk factors for poorer overall survival. Conclusion.The incidence of HBV reactivation was similar between the HBsAg-positive patients with anti-viral prophylaxis and the resolved HBV infection population without anti-HBV prophylaxis.All HBV reactivation events occurred in NHL patients exposed to rituximab.Late reactivation was not uncommon.

Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Light scattering from random rough dielectric surfaces

A theoretical and numerical study is made of the scattering of light and other electromagnetic waves from rough surfaces separating vacuum from a dielectric. The extinction theorem, both above and below the surface, is used to obtain the boundary values of the field and its normal derivative. Then we calculate the angular distribution of the ensemble average of intensity of the reflected and transmitted fields. The scattering equations are solved numerically by generating one-dimensional surface profiles through a Monte Carlo method. The effect of roughness σ and correlation distance T on the aforementioned angular distribution, as well as on the reflectance, is analyzed. Enhanced backscattering and new transmission effects are observed, also depending on the permittivity. The ratio σ/T is large in all cases studied, and thus no analytical approximation, such as the Kirchhoff approximation (KA) and small perturbation methods, could a priori be expected to hold. We find, however, that the range of validity of the KA can be much broader than that previously found in perfect conductors.

Topic: Surface Roughness and Optical Measurements
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Efficacy of BCG Vaccine

To the Editor. —Dr Colditz and colleagues1have reviewed and digested an enormous amount of data in producing their meta-analysis of the efficacy of BCG vaccine in the prevention of TB. However, there are major considerations that cast doubt on their conclusions. Among these considerations is the implication in the title and the text that there is only one BCG vaccine. Numerous authors have called attention to the fact that the BCG vaccines produced in different laboratories vary in almost every measurable characteristic.2,3Variations might be expected to occur in a vaccine that had to be subcultured as often as every 2 weeks from its release in 1922 until freeze-dried strains were developed in the mid 1960s.4Strains have been found to differ in their survival on culture media, colony formation, viability, drug resistance, DNA restriction fragments, virulence in animals, anti-TB and antitumor protection in animals, production

Topic: Tuberculosis Research and Epidemiology
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences