jimnoneill/paper-to-field-training huggingface dataset:
Data from Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Tumor infiltrating T lymphocytes in colorectal cancer (CRC) have prognostic impact, but the role of natural killer (NK) cells in CRC tissue is unclear. The contribution of intratumoral cytokines and chemokines in shaping the composition of the inflammatory lymphocytic infiltrate is also unclear.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; In this study, localization and densities of NK and T cells within primary CRC, CRC liver metastases, adenomas, and normal tissues were analyzed on whole tissue sections from 112 patients. In a subset of these patients, the most important 50 cytokines and chemokines were quantified in paired serum, primary CRC and adjacent mucosa samples and in CRC liver metastases and correlated with NK and T-cell infiltration, respectively.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The various compartments displayed characteristic differences like significantly higher chemokine concentrations in CRC tissue. Most importantly, despite high local chemokine levels, NK cells were generally scarce within CRC tumor tissues, independent of human leukocyte antigen (HLA) class I expression. Adjacent normal mucosa contained normal levels of NK cells. In contrast, corresponding T-cell numbers varied substantially and were positively correlated with higher chemokine levels.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our findings indicate a distinct regulation of NK cells versus T cells in the CRC tumor microenvironment. NK-cell migration into CRC tumor tissue is obviously impaired early during tumor development by mechanisms that do not affect T-cell infiltration. &lt;i&gt;Clin Cancer Res; 17(4); 678–89. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Evaluation of drug effects on spinal cord injury--an experimental study in monkeys.

Contusion injury is produced experimentally in anaesthetised monkeys by weight drop method. A group of animals having laminectomy alone served as sham controls. Drugs were administered 30 min after injury initially. Naloxone and nifedipine were administered as single dose administration immediately after injury. Dipyridamole and DMSO were administered daily for a period of 1 week. Acetylcholinesterase (AchE) was estimated in 2 spinal tissue segments, S1-at the site of injury and S2-the segment above the site of injury, at the end of 1 week after sacrificing the animals. Contusion injury produced significant decrease in specific activity of AchE in the traumatised segment of the experimental animals. The non-traumatised adjacent segment did not show any significant change. Nifedipine, naloxone and DMSO produced a decrease in AchE activity in S1 and S2 segments. Monkeys developed paraplegia after contusion injury. A score 2+ was observed after 1 week as compared to the score of 4+ of sham controls. Single dose administration of naloxone seemed to reverse the motor deficit by getting a score of 3+; other drugs did not produce any beneficial effect on motor deficit.

Topic: Cholinesterase and Neurodegenerative Diseases
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Supplementary Figure 1 from Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells

&lt;p&gt;Fig. S1. JG-98 does not affect density of endothelial cells (CD31 staining) and fibroblasts (SMA, smooth muscle actin staining) in the tumor.&lt;/p&gt;

Topic: Heat shock proteins research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Did Somebody Say Augustan Totalitarianism? Duncan Kennedy’s ‘Reflections,’ Hannah Arendt’s Origins, and the Continental Divide over Virgil’s Aeneid

The allegedly old-fashioned debate over the pro- or anti- Augustanism of Augustan texts was superseded in 1992 by Duncan Kennedy's 'reflections' over these terms of reference. Since then, the old dichotomy has appeared to be useless in a dialectic which is always bound to hold Augustus as the unavoidable point of reference. And yet scholarship continues to be divided over the interpretation of Augustus' rule and its visible or invisible effects on the poetry produced under his patronage. The present article revisits Kennedy's influential essay and its reception, arguing that it offers further reflections on the workings of Augustan ideology than it has so far been assumed. Moreover, while the nature of Augustus' rule is still a point of heated debate, the present article argues that a combined reading of Kennedy 1992 and Hannah Arendt's writings over the ideological language of totalitarian systems may open new possibilities for our interpretation the Augustan regime and the anti-Augustanism of the Augustan texts.

Topic: Hannah Arendt's Political Philosophy
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Walking stick misuse syndrome

The walking sick is the ordinary appliance for the people in inconvenient. It is frequently lead to pathological change of joint at digit wrist elbow and shoulder such as pain paralysis of nerve ending stiff joint and cyst. So it is very requisite to direct the people in inconvenient how to use walking sick for them convalescent.

Topic: Orthopedic Surgery and Rehabilitation
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Jimson Weed Poisoning

Comments and Corrections1 February 1976Jimson Weed PoisoningRICHARD LEVY, M.D., M.P.H.RICHARD LEVY, M.D., M.P.H.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-223 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent paper in this journal, Mikolich, Paulson, and Cross (1) described 10 cases of Jimson seed poisoning. They stated, "Induction of emesis may be beneficial in the conscious patient although the belladonna alkaloids are rapidly absorbed." From data obtained in the Emergency Unit of the University of Cincinnati Medical Center, their conclusion about the value of emesis appears to be understated. During September and October of 1975, 15 patients were seen who had swallowed Jimson weed. Serendepitously, one hallucinating patient was made to vomit approximately 36 hours after ingestion of the Jimson weed; the emesis...References1. MIKOLICH J, PAULSON G, and CROSS C: Acute anticholinergic syndrome due to Jimson seed ingestion. Ann Intern Med 83:321-325, 1975 LinkGoogle Scholar2. GOODMAN L and GILMAN A: The Pharmacological Basis of Therapeutics. New York, The MacMillan Co., 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD LEVY, M.D., M.P.H.Affiliations: Cincinnati General Hospital University of Cincinnati Medical Center Cincinnati, Ohio 45229 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOleander and Datura Poisoning: An UpdateRole of the Clinical Laboratory in Detecting Plant PoisoningIntoxication par Datura stramonium: Le diagnostic est clinique, le traitement est symptomatiqueAccidental Poisoning with Deadly Nightshade Berries: a Case ReportAnticholinergic poisoning from Jimson weed 1 February 1976Volume 84, Issue 2Page: 223-223KeywordsAlkaloidsIngestion ePublished: 1 December 2008 Issue Published: 1 February 1976 PDF downloadLoading ...

Topic: Plant-based Medicinal Research
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
The bark "Emanuel Accane" at a Portland, Oregon, harbor, ca. 1907

Pictured is the bark "Emanuel Accane" at a Portland harbor about 1907. She is a four masted, square rigged-sailing ship. A steamship and other sailing vessels can be seen in the background.

Topic: Magnetic confinement fusion research
Subfield: Nuclear and High Energy Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Association of PM2.5 concentration with health center outpatient visits for respiratory diseases of children under 5 years old in Lima, Peru

Abstract Background Lima is one of the more polluted cities in Latin America. High levels of PM 2.5 have been shown to increase health center outpatient visits of respiratory diseases. Methods Health center outpatient visits for children < 5 years for childhood respiratory disease (acute lower respiratory infections (ALRI), pneumonia and acute bronchiolitis/asthma) from 498 public clinics in Lima were available on a weekly basis from 2011 to 2015 from Peru's Ministry of Health (MINSA). The association between the average weekly concentrations of PM 2.5 was evaluated in relation to the number of weekly health center outpatient visits for children. Weekly PM 2.5 values were estimated using a recently developed model that combined data observed from ground monitors, with data from space satellite and meteorology. Ground monitoring data came from 10 fixed stations of the Peruvian National Service of Meteorology and Hydrology (SENAMHI) and from 6 mobile stations located in San Juan de Miraflores by Johns Hopkins University. We conducted a time-series analysis using a negative binomial model. Results We found a significant association between exposure to PM 2.5 and all three types of respiratory diseases, across all age groups. For an interquartile increase in PM 2.5 , we found an increase of 6% for acute lower respiratory infections, an increase of 16–19% for pneumonia, and an increase of 10% for acute bronchiolitis / asthma. Conclusions Higher emissions of environmental pollutants such as PM 2,5 could be a trigger for the increase of health center outpatients visits for respiratory diseases (ALRI, pneumonia and asthma), which are themselves risk factors for mortality for children in Lima province, Peru.

Topic: Air Quality and Health Impacts
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
On a tangent equation by primes

Abstract In this paper, we introduce a new diophantine equation with prime numbers. Let <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:mo stretchy="false">[</m:mo> <m:mo lspace="4.2pt" rspace="4.2pt">⋅</m:mo> <m:mo stretchy="false">]</m:mo> </m:mrow> </m:math> [\,\cdot\,] be the floor function. We prove that, when <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:mn>1</m:mn> <m:mo>&lt;</m:mo> <m:mi>c</m:mi> <m:mo>&lt;</m:mo> <m:mfrac> <m:mn>23</m:mn> <m:mn>21</m:mn> </m:mfrac> </m:mrow> </m:math> 1&lt;c&lt;\frac{23}{21} and <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:mi>θ</m:mi> <m:mo>&gt;</m:mo> <m:mn>1</m:mn> </m:mrow> </m:math> \theta&gt;1 is fixed, then every sufficiently large positive integer 𝑁 can be represented in the form <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:mrow> <m:mi>N</m:mi> <m:mo>=</m:mo> <m:mrow> <m:mrow> <m:mo stretchy="false">[</m:mo> <m:mrow> <m:msubsup> <m:mi>p</m:mi> <m:mn>1</m:mn> <m:mi>c</m:mi> </m:msubsup> <m:mo>⁢</m:mo> <m:mrow> <m:msup> <m:mi>tan</m:mi> <m:mi>θ</m:mi> </m:msup> <m:mo>⁡</m:mo> <m:mrow> <m:mo stretchy="false">(</m:mo> <m:mrow> <m:mi>log</m:mi> <m:mo>⁡</m:mo> <m:msub> <m:mi>p</m:mi> <m:mn>1</m:mn> </m:msub> </m:mrow> <m:mo stretchy="false">)</m:mo> </m:mrow> </m:mrow> </m:mrow> <m:mo stretchy="false">]</m:mo> </m:mrow> <m:mo>+</m:mo> <m:mrow> <m:mo stretchy="false">[</m:mo> <m:mrow> <m:msubsup> <m:mi>p</m:mi> <m:mn>2</m:mn> <m:mi>c</m:mi> </m:msubsup> <m:mo>⁢</m:mo> <m:mrow> <m:msup> <m:mi>tan</m:mi> <m:mi>θ</m:mi> </m:msup> <m:mo>⁡</m:mo> <m:mrow> <m:mo stretchy="false">(</m:mo> <m:mrow> <m:mi>log</m:mi> <m:mo>⁡</m:mo> <m:msub> <m:mi>p</m:mi> <m:mn>2</m:mn> </m:msub> </m:mrow> <m:mo stretchy="false">)</m:mo> </m:mrow> </m:mrow> </m:mrow> <m:mo stretchy="false">]</m:mo> </m:mrow> <m:mo>+</m:mo> <m:mrow> <m:mo stretchy="false">[</m:mo> <m:mrow> <m:msubsup> <m:mi>p</m:mi> <m:mn>3</m:mn> <m:mi>c</m:mi> </m:msubsup> <m:mo>⁢</m:mo> <m:mrow> <m:msup> <m:mi>tan</m:mi> <m:mi>θ</m:mi> </m:msup> <m:mo>⁡</m:mo> <m:mrow> <m:mo stretchy="false">(</m:mo> <m:mrow> <m:mi>log</m:mi> <m:mo>⁡</m:mo> <m:msub> <m:mi>p</m:mi> <m:mn>3</m:mn> </m:msub> </m:mrow> <m:mo stretchy="false">)</m:mo> </m:mrow> </m:mrow> </m:mrow> <m:mo stretchy="false">]</m:mo> </m:mrow> </m:mrow> </m:mrow> <m:mo>,</m:mo> </m:mrow> </m:math> N=[p^{c}_{1}\tan^{\theta}(\log p_{1})]+[p^{c}_{2}\tan^{\theta}(\log p_{2})]+[p^{c}_{3}\tan^{\theta}(\log p_{3})], where <m:math xmlns:m="http://www.w3.org/1998/Math/MathML"> <m:mrow> <m:msub> <m:mi>p</m:mi> <m:mn>1</m:mn> </m:msub> <m:mo>,</m:mo> <m:msub> <m:mi>p</m:mi> <m:mn>2</m:mn> </m:msub> <m:mo>,</m:mo> <m:msub>

Topic: Analytic Number Theory Research
Subfield: Algebra and Number Theory
Field: Mathematics
Domain: Physical Sciences
RESEARCH AND CONSULTANCY: TOWARDS A CONCEPTUAL SYNTHESIS

ABSTRACT This paper describes an investigation into some of the apparent similarities between what certain kinds of researchers and consultants do in organizations. Using a facet analysis approach (Foa, 1965), an instrument was devised with the purpose of identifying and delineating overlaps between organizational research and consultancy. Sixty‐six British researchers and consultants took part in the study. The results highlight certain specific similarities and suggest that these may represent aspects of research and consultancy which are crucial to their success. The facets of the two activities which emerged from the study as being common are described by reference to the qualitative data which were generated by participants. A number of important implications for the successful conduct of research and consultancy are discussed with particular reference to the process of managing the relationship between investigators and those with whom they work.

Topic: Qualitative Research Methods and Applications
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
CORRELATION BETWEEN INCLINATION OF THE ACETABULAR COMPONENT AND METAL ION LEVELS IN METAL ON METAL HIP REPLACEMENT

Introduction The advantages of metal on metal (MOM) hip replacement are decreased wear rate, preservation of bone stock, anatomical restoration and enhanced stability. Large amounts of metal wear particles and metal ions are released which may induce adverse reactions including local soft tissue toxicity, hypersensitivity reactions, bone loss and risk of carcinogenesis. Aseptic loosening can be the result of a peri prosthetic osteolysis generated as a result of a biological response to particulate wear debris. Our aim in this study was to determine whether a steeply inclined acetabular component would give rise to a higher concentration of metal ions. Patients and methods Between April 2003 and June 2006, 22 patients had MOM hip replacement for osteoarthritis by a single Surgeon. There were 12 male and 10 female patients. The average age at the time of surgery was 56 years (Range: 44–69 years). We divided the 22 patients into 2 groups, one group (A) of 11 patients with the acetabular inclination angle more than 50 degrees and the other group (B) of 11 patients with the angle less than 50 degrees. The inclination of the acetabular cup was measured using a standard AP radiograph of the pelvis. The patients had metal ion levels (blood chromium and serum cobalt) measured at an average follow up of 3.2 years (Range 2.4 to 5 years). Results Mean blood chromium level in the group A (146 nM/L) was significantly higher (p=0.005) than in Group B (92 nM/L). Mean serum cobalt level in the group A (245 nM/L) was significantly higher (p=0.002) than in Group B (110 nM/L). Discussion The early to mid term published results of MOM hip replacements have been encouraging. There are, however, a number of concerns about the MOM bearing. Although its wear rate is low, it still releases metal ions into the body particularly cobalt and chromium since most metal on metal bearings are made of a cobalt chromium alloy. The long-term consequences of increased levels of these ions in the body are not known. High concentrations of Co and Cr are toxic and are known to interfere with a number of biological functions. There also have been recent reports of soft tissue reactions with MOM hip replacement. In the light of these concerns, it is important to examine factors which may influence the release of metal ions after MOM hip replacement. It has been reported in the recent literature that the position of the acetabular component will influence the bearing wear inturn leading to the release of metal ions after MOM hip replacement. Our findings indicate that steeply inclined acetabular components with an inclination angle greater than 50 degrees gives rise to higher concentration of metal ions.

Topic: Orthopaedic implants and arthroplasty
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
INTERACT Reducing the Environmental Impacts of Arctic Fieldwork

The INTERACT Reducing the Environmental Impacts of Arctic Fieldwork guidebook provides an overview of general environmetal impacts and recommendations on how to reduce these of research activities in the Arctic and northern cold regions. The book is produced by managers of the &gt;85 research stations embedded in the INTERACT network. The target audience are scientists working in northern cold regions often challenged by remote locations, harch climate and pristine environment. It provides recommendations for considerations to be made when planmning fieldwork, at the research station, in the field and post fieldwork evaluation.

Topic: Indigenous Studies and Ecology
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences
A Prescriptive Approach to Assign Weights to Customer Needs for System Design

It is a common practice to assign weights to customer needs in Requirements Engineering. However, there are three hidden traps underlying this practice, which may lead to distortion of customer preferences. Aiming to mitigate these traps, a three-step approach based on group decision analysis is proposed. In the 1st step, real customer needs are identified and structured. Then, measurable attributes are identified for each customer need and used as the input parameters to establish a multi-attribute utility function for individuals. In the 3rd step, customer group’s different preferences are derived from individual customer’s preference to determine a final weight for each customer need. The approach is validated through a case study.

Topic: Quality Function Deployment in Product Design
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
A Study on the Technology Addiction and its Impacts among Adolescent

Tech Addiction is a plethora of different kind of addiction involves mobile phone addiction, social media addiction, internet addiction, game addiction, web series and chat addiction. These are the some kind of addictions that attracts the adolescent peoples around the world. Other than this there are some of the addictions that create massive variations in the brain activity which include drug and alcohol addiction. Due to this the adolescent people most often prone into the stressful situation. They think these addictions provide pleasure and releases stress temporarily. However it creates the impacts on the human brain and its functions.

Topic: Impact of Technology on Adolescents
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Designing Cloud Security and Operations Models in the Changed Geopolitical Environment

Historically, the paradigm of cloud emerges from the telecommunications industry. is is where operators commonly oer virtual private network (VPN) services, which bear similar services quality in term of engineering (see Figure 5.3), but charge a very low cost of execution. is averts the former situation in telecommunication in which dedicated pointto-point telecommunication circuits show a high degree of resources redundancy. Cloud computing provokes a more balanced utilization of network and computing resources in servers (Wood et al., 2011). Users can access data, applications, and other resources plainly through a computer browser. is is independent of the devices used and available at any location where users stay. Cloud infrastructure is supported through the latest state of art of internet infrastructure oering high resiliency in throughput and reliability such that more intensive computing jobs can be handled.

Topic: Network Security and Intrusion Detection
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Dalpiciclib combined with chidamide and letrozole as neoadjuvant therapy for HR-positive, HER2-negative early or locally advanced breast cancer: A single-arm, prospective, exploratory clinical study.

e12593 Background: Hormone receptor (HR)-positive/ human epidermal growth factor receptor 2 (HER2)-negative breast cancer (BC) exhibits lower rates of pathologic complete response and objective response rate (ORR) to neoadjuvant therapy, highlighting an urgent clinical need for more effective alternatives. Dalpiciclib is a novel CDK4/6 inhibitor, and chidamide is an orally selective histone deacetylase inhibitor. This study aims to explore the efficacy and safety of dalpiciclib plus chidamide and letrozole as neoadjuvant therapy for HR-positive/HER2-negative BC. Methods: This is a single-arm, open-label study that enrolled patients with early or locally advanced HR-positive/HER2-negative BC. After enrollment, patients received six 28-day cycles of dalpiciclib (100 mg, po, qd, d1-21) plus chidamide (20mg, biw, po, d1-21) and letrozole (2.5 mg, qd, po) as neoadjuvant therapy. Tumor response was assessed according to RECIST 1.1 by MRI examination every 2 cycles until surgery. Surgical treatment will be performed within 2-4 weeks after the end of neoadjuvant therapy, and subsequent adjuvant therapy will be carried out by the investigator according to the actual situation of the subject. The primary endpoint was residual cancer burden score of 0 or I (RCB 0/I), and the secondary endpoints were the total pathological complete response rate (tpCR; ypT0/is and ypN0), objective response rate (ORR) and safety analysis. This study is registered with China Clinical Trials Registry (ChiCTR2400081280). Results: From August 2023 to January 2025, 23 patients were enrolled in our study. All patients had ER expression ≥ 50%, and 74% (17/23) had Ki67 expression ≥ 20%. Among the 12 patients completed neoadjuvant therapy and underwent surgery, the postoperative RCB 0/I was 25% (95% CI, 5.5%-49.5%), tpCR was 25% (95% CI, 5.5%-49.5%), ORR was 92% (95% CI, 61.5%-100.0%). Among the 20 patients who completed the assessment after 2 cycles, the ORR was 75% (95% CI, 50.9%-94.0%). The most common adverse events (AEs) were decreased neutrophil count (100%) and decreased white blood cell count (86%), with grade ≥3 AEs occurring in 82% and 55% of patients, respectively. While other AEs were predominantly grade 1 or 2. Conclusions: Our results showed thatthe combination of dalpiciclib, chidamide and letrozole demonstrates an acceptable safety profile and promising clinical efficacy, suggesting its potential as an alternative fully oral, chemotherapy-free neoadjuvant treatment for HR-positive, HER2-negative early or locally advanced breast cancer. Further research is needed to validate these findings. Clinical trial information: ChiCTR2400081280 .

Topic: Advanced Breast Cancer Therapies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences