jimnoneill/paper-to-field-training huggingface dataset:
Evaluation of t(14;18)(q32;q21) and BCL2 protein and their prognostic role in follicular lymphoma

Background: Previous reports have suggested the significant association of t(14;18) (q32;q21) and follicular lymphoma (FL).However, little information is available in the literature on the relationship between BCL2 protein, BCL2 gene status in FL and the patient outcomes.Also, understanding of IGH/BCL2 molecular rearrangement using real time PCR (RT-PCR), in follicular lymphoma in relation to survival might provide a more accurate and rational method of risk stratification to guide treatment and might suggest new therapeutic approaches as well.Methods: This study evaluated the relative frequency of t(14;18) by RT-PCR and its apoptosis-related BCL2 protein expression by an immunohistochemical assay (IHC) in fifty FL cases in tissues.In addition, we evaluated the relation of BCL2 protein expression to the translocation, together with the relation of both t(14;18) and BCL2 protein expression to the clinico-pathological features and survival data including progression free survival (PFS); and overall survival (OS) in order to evaluate their prognostic role in FL. Results & conclusion:There was a significant association of the t(14;18) with BCL2 protein expression, grading of FL, and the OS.In addition, there was a significant association of BCL2 protein expression with the grading of FL, OS, International Prognostic Index (IPI) score and performance status.However no significant association of t(14;18) or BCL2 protein expression with the other clinico-pathological features, and PFS..

Topic: Lymphoma Diagnosis and Treatment
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
The Image of Alexander the Great in Persian History, Epic and Romance

The figure of Alexander the Great (Iskandar) features large in the historical and romantic literature of East and West. This paper compares the treatment of Alexander in different genres of Persian writings, particularly the way his career is illustrated in manuscript painting. We see, first, an enormous corpus of images depicting scenes from the early eleventh-century epic poem, the Shahnama of Firdausi, in manuscripts dating from the early fourteenth century to the early modern period. We then see how a later literary development of Firdausi’s work in the romance epic by the twelfth-century poet Nizami treats Iskandar’s life as a philosopher and seeker of truth. In striking contrast, only a handful of Persian chronicles purporting to provide a ‘historical’ account of his reign, which are also illustrated from the fourteenth century, depict only two episodes: Iskandar and the dying Dara (Darius) and Iskandar entering the northern darkness. This visual repertoire remains constant regardless of the text, but it is remarkable that the self-identified historical works contain a far more restrained illustrative programme than those that aim for a more popular audience with a strongly narrative and mystical purpose.

Topic: Eurasian Exchange Networks
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
THE PHYSICAL PROPERTIES AND THE INFLUENTIAL FACTORS OF THE CRUDE OIL IN SANTANGHU BASIN

Based on the research on physical properties and the distribution characteristics of crude oil in Santanghu basin, combining the geological condition, the authors analyze the influencial factors of the physical properties of crude oil. It is shown that physical characteristics of crude oil depend not only on group compositions, but also on maturity, burial depth, preservation condition and compositional gravity differentiation. The factors of influence on density include content of saturation hydrocarbon, arocomatic hydrocarbon, resin, asphaltene and wax. Viscosity mainly depends on content of saturation hydrocarbon, arocomatic hydrocarbon and resin, not on asphltene and wax. For the change of physical properties of the crude oil in Lucaogou Formation, Niujuanhu oil field, the bigger its depth is, the higher its viscosity, which are different from other area and stratum, and it is the result of gravity differentiation of different hydrocarbons. The physical properties variation of crude oil in other area decrease as its depth increasing, mainly related to preservation condition, water leaching and oxidation, the recognition is of an importance to other areas in the research on physical property distribution characyeristics of crude oil.

Topic: Hydrocarbon exploration and reservoir analysis
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences
An Aesthetic Defense of Imagination:A Formal Analysis of Edgar Allan Poe’s “Colloquy of Monos and Una”

This thesis discusses two main topics. Firstly, it explains the value of aesthetic literary criticism as opposed to ideological critical methods. Secondly, this thesis contains a formal, aesthetic analysis of Edgar Allan Poe’s “Colloquy of Monos and Una.” This analysis exemplifies the value of aesthetic criticism by deconstructing the colloquy’s form and content and considering how the relationship between form and content affects an interpretation of Poe’s work.

Topic: Artistic and Creative Research
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Engineering Control of Complement Inhibition at the Cell Surface

The role of complement regulation at the cell surface is reviewed and the desirability of being able to design exogenous therapeutic agents that function in this way is considered. An analysis of naturally occurring membrane proteins suggested that one particular type of membrane-localization mechanism (the myristoyl-electrostatic peptide switch) could be mimicked by minimization of the key molecular features involved and incorporation into relatively simple synthetic protein modification agents that could be attached to soluble proteins with retention of water solubility. This approach amounts to reconstruction of a membrane protein by substitution of the natural anchor by a more chemically tractable structure. It allows solution of a number of practical problems associated with production of recombinant membrane-interactive proteins and has permitted the development of one such protein (APT070, Mirococept) as a pharmaceutical agent. The membrane-binding properties of APT070 make it not only a potent regulator of complement activation but also permit it to be used in experimental and therapeutic situations where conventional soluble biopharmaceuticals are of limited use. Two such clinical applications of APT070 and the scope for application of other complement regulators such as CD59 in these reconstructed forms are also outlined.

Topic: Complement system in diseases
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Early Warning Measurement of SARS-CoV-2 Variants of Concern in Wastewaters by Mass Spectrometry

Wastewater surveillance has rapidly emerged as an early warning tool to track COVID-19. However, the early warning measurement of new SARS-CoV-2 variants of concern (VOCs) in wastewaters remains a major challenge. We herein report a rapid analytical strategy for quantitative measurement of VOCs, which couples nested polymerase chain reaction and liquid chromatography-mass spectrometry (nPCR-LC-MS). This method showed a greater selectivity than the current allele-specific quantitative PCR (AS-qPCR) for tracking new VOC and allowed the detection of multiple signature mutations in a single measurement. By measuring the Omicron variant in wastewaters across nine Ontario wastewater treatment plants serving over a three million population, the nPCR-LC-MS method demonstrated a better quantification accuracy than next-generation sequencing (NGS), particularly at the early stage of community spreading of Omicron. This work addresses a major challenge for current SARS-CoV-2 wastewater surveillance by rapidly and accurately measuring VOCs in wastewaters for early warning.

Topic: SARS-CoV-2 detection and testing
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Waterline Erosion Control Essential To Streambank Rehabilitation

Tests of streambank erosion control measures on three Michigan streams have shown the key role of waterline stabilization. After undercutting was stopped, the upper banks were revegetated in 1 to 5 years depending on treatment. Without waterline control, all revegetation efforts were ineffective.

Topic: Soil erosion and sediment transport
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Ectomycorrhizal status of a mature productive black truffle plantation

The truffle-plantation “Los Quejigares” was planted in 1971 by AROTZ-CATESA company. It is a 600 ha plot of Quercus ilex mycorrhizated with Tuber melanosporum at 1250 m a.s.l. on calcareous soil. This plantation is the largest of the world and one of the eldest truffle-plantations of Spain and it is in full production. Knowledge of the mycorrhizal status of a mature black truffle plantation is significant for the improvement of truffle cultivation. Ectomycorrhizae were studied for knowing T. melanosporum persistence and diversity and abundance of other ectomycorrhizal types. Roots of 16 holmoaks were sampled, 12 trees produce truffle sporocarps and four did not. It was found a mean of about 70% of T. melanosporum ectomycorrhizae in all the studied trees, independently of their capacity to produce or not sporocarps. Also, 105 more different ectomycorrhizal types were found. In spite of the high number of morphotypes found, it seems that they do not replace T. melanosporum, showing that there is a coexistence between species in the fungal community associated to the roots.

Topic: Mycorrhizal Fungi and Plant Interactions
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Escaping Discussion: Liminality and the Female-Embodied Couple in Mary Wollstonecraft's Mary, A Fiction

Escaping Discussion: Liminality and the Female-Embodied Couple in Mary Wollstonecraft's Mary, A Fiction. Un article de la revue Romanticism on the Net (Romantic Couplings) diffusée par la plateforme Érudit.

Topic: Religion, Gender, and Enlightenment
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
An Error Recovery Mechanism for Wireless Sensor Networks

In wireless sensor networks, the importance of transporting data correctly with reliability is increasing gradually along with the need to support communications between the nodes and sink. Data flow from the sink to the nodes requires reliability for control or management that is very sensitive and intolerant of error; however, data flow from the nodes to the sink is relatively tolerant. In this paper, with emphasis on the data flow from the sink to the nodes, we propose a mechanism that considers accurate transport with reliability hop-by-hop. During the process of sending the data, if errors occur or data is missing, the proposed mechanism supports error recovery using a fixed window with selective acknowledgment. In addition, this mechanism supports congestion control depending on the buffer condition. Through the simulation, we show that this mechanism is accurate, reliable, and proper for transport in wireless sensor networks.

Topic: Energy Efficient Wireless Sensor Networks
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Fiber Optic Distribution Networks for Military Applications

A number of military applications require ad-hoc wireless commumcation and networking systems that employ low phase noise reference signals for up- and down- conversion of communication signals and further processing of data signals. High performance fiber optic links are important for distribution of signals while phase noise degradation induced by AM-PM conversion in fiberoptic links impacts phase coherency of local oscillator (LO) signals in distributed systems. This paper focuses on issues associated with directly and externally modulated fiber optic links and their performance limitations in terms of gain, noise figure, nonlinearity, and dynamic range. The performance-cost aspects of both types of links are compared and it is pointed out that directly modulated links meet performance-cost requirements in most applications. Analysis of phase noise degradation of frequency reference is presented for directly modulated fiber optic distribution networks. SRS induced fiber nonlinearity is also discussed. Since the response of a Fabry-Perot laser diode can be altered by adding an external feedback, resulting in a resonance peak, results of a monolithically integrated FP laser are discussed. Finally, opto-electronic mixing of IF and LO signals are also demonstrated for the mode-locked case.

Topic: Advanced Photonic Communication Systems
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Exploiting spatial and temporal locality for seamless vertical handover

Seamless vertical handover is a key requirement in heterogeneous wireless networks where different networks are integrated. In this paper, we introduce an enhanced information server (EIS) in the IEEE 802.21 media independent handover (MIH) architecture. We also propose an improved vertical handover procedure in which the wireless channel condition is estimated by exploiting spatial and temporal locality at the EIS. Simulation results demonstrate that the proposed scheme can reduce the vertical handover latency by 13% by eliminating time-consuming channel scanning procedure.

Topic: IPv6, Mobility, Handover, Networks, Security
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Investigation of an Homologous Series of Fatty Acids by TLC. II. Comparison of Separation of Fatty Acids on RP‐18 Plates with Different Mobile Phases

Abstract Fatty acids from octanoic acid to octadecanoic acid have been separated on RP‐18 plates with and without a concentrating zone using methanol–water, ethanol–water, and n‐propanol–water as mobile phases. The cluster analysis for comparison of R M parameters of investigated acids for chromatographic conditions used was proposed. Comparison of differences between R F values showed that acids from nonanoic to octadecanoic are separated on the longest distance, using as mobile phase methanol–water in a volume ratio of 95 + 5 and on RP‐18 plates with and without concentrating zone. Moreover, resolution factor values (R S) calculated suggest that better separations of acids from octanoic to octadecanoic were obtained on RP‐18 plates with a concentrating zone and methanol–water (95 + 5, v/v) as mobile phase.

Topic: Analytical Chemistry and Chromatography
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Addictive Potential, Behavioral and Psychiatric Effects

Adolescent Drug-Abuse Treatment Programs in five geographic regions across the United States were studied to determine the severity and patterns of cocaine abuse. Of these, 341 admitted to cocaine use and became part of this survey. Cocaine use was categorized as heavy, intermediate, or light. Areas examined were the addictive spectrum, psychosocial dysfunction, and psychiatric symptoms. Intermediate and heavy users of cocaine abused significantly less marijuana and inhalants than light cocaine abusers. Heavy and intermediate users were more likely to use cocaine intravenously and to use crack. They developed tachyphylaxis more frequently, progressed to weekly use in less than 3 months more frequently, and became preoccupied with obtaining and using cocaine significantly more frequently. They used more sedative hypnotics to calm themselves and engaged in more criminal behavior, such as stealing from parents and stores and passing bad checks. They had more arrests for possession of drugs, stole more cars, sold more drugs, and were more likely to trade sexual favors to obtain the drug. Heavy and intermediate users were significantly more psychiatrically disturbed than light users, becoming more suspicious, nervous, aggressive, and demonstrating increased symptoms of fatigue, sleeplessness, decreased appetite, and increasing cocaine dysphoria. All of these symptoms could be mistaken for psychiatric disorders. This study suggests that cocaine is as addictive in adolescents as in adults; possibly more so. It also causes psychosocial dysfunction and psychiatric symptoms. Further research into cocaine addiction among adolescents is indicated.

Topic: Neuroscience of respiration and sleep
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
JS04.5.A HIGH RESOLUTION DRUG-RESISTANT MAPPING OF ALK FUSION VARIANTS USING PRIME EDITING

Abstract BACKGROUND Anaplastic lymphoma kinase (ALK) gene fusions are potent oncogenic drivers across diverse malignancies, including non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL), breast cancer, and glioma. These fusions lead to constitutive activation of the ALK tyrosine kinase domain (TKD), rendering tumors initially responsive to ALK tyrosine kinase inhibitors (TKIs)—primarily in NSCLC, but also in rare cases such as infant-type hemispheric glioma. However, resistance inevitably emerges, frequently due to acquired single nucleotide variants (SNVs) within the TKD. A significant proportion of these SNVs are classified as variants of uncertain significance (VUSs), highlighting the need for systematic functional annotation to inform precision therapy. MATERIAL AND METHODS We employed prime editing to introduce all possible SNVs across the ALK TKD (exons 20-28). High-throughput drug resistance screening was conducted against three generations of ALK TKIs: alectinib (second-generation), lorlatinib (third-generation), and zotizalkib (fourth-generation, previously evaluated in clinical trials). Resistance classification data were further assessed using Kaplan-Meier survival analyses to explore potential prognostic implications. RESULTS A total of 2,953 SNVs (99.2% of all possible variants in exons 20-28) were successfully introduced and profiled. Resistance phenotypes were comprehensively mapped for each variant across the three TKIs. Canonical resistance mutations such as G1202R and L1196M were accurately recapitulated, validating our screening platform. Moreover, several previously uncharacterized VUSs were identified as conferring differential resistance profiles. Structural modeling revealed mechanistic insights into altered TKI binding. These findings aligned with existing clinical and preclinical datasets and expanded the known spectrum of clinically actionable ALK resistance mutations. CONCLUSION This study presents the most comprehensive functional landscape to date of ALK TKD variants in the context of TKI resistance. Our data provide an invaluable resource for interpreting VUSs, optimizing TKI selection, and advancing personalized treatment in ALK fusion-positive cancers. Furthermore, the approach and insights are broadly applicable to other ALK-rearranged malignancies, including glioma.

Topic: Innovative Microfluidic and Catalytic Techniques Innovation
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Geodynamics Observing Techniques at the Observatory Hvar (Croatia)

The Observatory Hvar will be equipped with several geodetic and geophysical instruments for deformation monitoring of the Adriatic microplate. It was planned to install a TRIMBLE GNSS receiver a LaCoste & Romberg ET gravity meter, several tiltmeters and a vertikal ekstensometer. Via LAN the measured Data will be transferred to a host computer for analysis. The CROPOS net will be used for a surface analysis especially for the Adriatic microplate under the influence of loading effects. At the momment all instruments are installed at the RGN faculty Zagreb for testing.

Topic: Geophysics and Gravity Measurements
Subfield: Oceanography
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Complications;

Rare pulmonary complications after transarterial chemoembolisation for hepatocellular carcinoma: two case reports We report two rare cases of acute pulmonary complication after transarterial chemoembolisation for inoperable hepatocellular carcinoma. Both cases involved a large tumour and hepatic vein invasion. The first patient, a 27-year-old man, died of pulmonary tumour embolism 4 days after transarterial chemoembolisation. Acute dyspnoea developed in the second patient, a 63-year-old man, following the procedure due to pulmonary oil embolisation and chemical pneumonitis. The chest condition of this patient improved, but he subsequently died of liver failure 3 weeks later. Our cases illustrate the point that if locoregional treatment is offered as a palliative treatment, patients with hepatic vein invasion should be warned of the possible complications of massive tumour embolism, pulmonary oil embolisation, and subsequent death. !&amp;quot;#$%&amp;amp;&amp;apos;()&amp;apos;*+,-./01234562789:;&amp;lt;&amp;amp;.=

Topic: Metamaterials and Metasurfaces Applications
Subfield: Electronic, Optical and Magnetic Materials
Field: Materials Science
Domain: Physical Sciences
Effects of water stress on curly Mitchell grass, the common armyworm and the Australian plague locust

Temporal water and nitrogen relations of curly Mitchell grass, Astrebla lappacea (Lindl.) Domin, in response to single waterings of 0, 20, 60 and 180 mm were studied. Effects on the survival and development of the common armyworm, Mythimna convecta (Walker), and the Australian plague locust, Chortoicetes terminifera (Walker), were recorded. Glasshouse trials were conducted to ascertain the level of rainfall required for insect survival. More than 20 mm of rainfall was needed for insect survival. Even at 60 mm, development was retarded in some instances. Plant nitrogen was positively correlated (R2 = 0.51) with plant moisture. Insect survival was better correlated with plant moisture (R2 = 0.61) than with plant nitrogen (R2 = 0.41).

Topic: Lepidoptera: Biology and Taxonomy
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Theoretical study of ultrafast index dynamics in semiconductor optical amplifiers

We proposed a novel extended semiconductor optical amplifier （SOA） model for applications in femtosecond pulse transmission，in which various ultrafast nonlinear effects，such as gain dispersion and group velocity dispersion were taken into account. We analyzed the refractive index in response to variation of the input current and the length of SOA. Furthermore，the impact of carrier density pulsation and carrier heating on the refractive index dynamics of SOA was discussed respectively. The simulation model can be applied in parameter and operation condition optimization of SOAs in order to improve their femtosecond dynamic characteristics.

Topic: Optical Network Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences