jimnoneill/paper-to-field-training huggingface dataset:
Regulation of Airway Epithelial Cell NF-κB-Dependent Gene Expression by Protein Kinase Cδ

Abstract Airway epithelial cells synthesize proinflammatory molecules such as IL-8, GM-CSF, RANTES, and ICAM-1, the expression of which is increased in the airways of patients with asthma. We investigated the regulation of these NF-κB-dependent genes by the novel protein kinase C (PKC) isoform PKCδ in 16HBE14o- human airway epithelial cells, focusing on IL-8 expression. Transient transfection with the constitutively active catalytic subunit of PKCδ (PKCδ-CAT), and treatment with bryostatin 1, an activator of PKCδ, each increased transcription from the IL-8 promoter, whereas overexpression of PKCε had minor effects. Expression of a dominant negative PKCδ mutant (PKCδ-KR) or pretreatment of cells with rottlerin, a chemical PKCδ inhibitor, attenuated TNF-α- and phorbol ester-induced transcription from the IL-8 promoter. Bryostatin 1 treatment increased IL-8 protein abundance in primary airway epithelial cells. Selective activation of PKCδ by bryostatin also activated NF-κB, as evidenced by p65 RelA and p50 NF-κB1 binding to DNA, NF-κB trans-activation, and IκB degradation. The sufficiency of PKCδ to induce NF-κB nuclear translocation and binding to DNA was confirmed in a 16HBE14o- cell line inducibly expressing PKCδ-CAT under the tet-off system. Deletion of the NF-κB response element severely attenuated PKCδ-induced IL-8 promoter activity. Finally, PKCδ-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKCδ plays a key role in the regulation of airway epithelial cell NF-κB-dependent gene expression.

Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
memo to molecule manipulators about . . . National® DODECENYLSUCCINIC ANHYDRIDE

RETURN TO ISSUEPREVAdvertisementNEXTmemo to molecule manipulators about . . . National® DODECENYLSUCCINIC ANHYDRIDECite this: Chem. Eng. News 1960, 38, 38, 26Publication Date (Print):September 19, 1960Publication History Published online6 November 2010Published inissue 19 September 1960https://doi.org/10.1021/cen-v038n038.p026Copyright © 1960 AMERICAN CHEMICAL SOCIETYArticle Views48Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (501 KB) SUBJECTS:Molecules Get e-Alerts

Topic: Various Chemistry Research Topics
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Influence of Fresh Chopped Leaves and Dry Leaf Powder of some Horticultural Trees on Controlling Root-knot Nematode, Meloidogyne javanica on Broad Bean

Fresh chopped and dry leaf powders of china berry(Melia azedarachta), golden chain (Cassia fistula), luciana (Lucaena Leucocephala), poinciana (Poinciana regia) and purple orchid (Bauhinia Variegata) was applied as soil amendments at rates of 5, 10, 15 and 20 g / kg soil to control the root-knot nematode, Meloidogyne javanica infecting broad bean cv.Maser-1 under greenhouse conditions.Result revealed that all powder or chopped amendments suppressed population of nematode and fewer root galls per plant were formed special at the highest rates of amendments.All treatments significantly (P ≤ 0.05) decreased nematode criteria when compared to untreated (check).In general, there was a positive correlation between the tested rates and the percentages reduction in nematode parameters higher rates of chopped or dry leaves were caused higher percentage nematode reduction, when compared the whole averages of materials with each other in controlling nematode parameters.Also, almost the treatments of dry leaf powder amendments succeeded in improving the plant growth than unamended soil as evidence in increment of lengths and fresh weights of both shoots and roots.Also, the increase in such parameters of plant growth clear differences according to the type and the amount of materials used.

Topic: Nematode management and characterization studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Adaptation to vestibular disturbances Some clinical implications

The topographic arrangement of the fascicular portion of the oculomotor nerve in the midbrain is not known. A patient with infarction involving the lateral portion of the fascicle had isolated monocular elevation paresis and ptosis, suggesting that the fibers destined to the elevators of the eye and eyelid course laterally in the fascicle.

Topic: Vestibular and auditory disorders
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
A simulation of growth duration in FACE rice

Global atmospheric CO2 concentration([CO2]) was projected to reach levels of 650-780 μmol mol-1 at the end of this century(IPCC,2000).The increasing atmospheric [CO2] and associated climate may greatly affect agricultural productivity worldwide.However,little was known about the effect of free-air CO2 enrichment(FACE) on growth duration of rice.In order to predict the changes of growth duration of under FACE condition,we conducted a FACE experiment at Anzhen(31°37′N,120°28′E),Wuxi,Jiangsu province,in 2001-2003.The FACE facility consisted of three FACE rings(three repetitions) and five ambient rings,and the ambient rings were 90m apart to avoid contamination of elevated CO2.Rice were grown from transplanting to harvest under two levels of [CO2] for three consecutive years(2001-2003),and the target [CO2] of the FACE rings was 200μmol mol-1 above that in the ambient air.The annual mean temperature was about 16℃,the annual mean rainfall was 1150 mm and the annual sunshine hours were 2000h in the experiment area.The experiment was conducted in 3 years using the japonica cultivar Wuxiangjing 14.Seeds were sowed on 18 May and seedlings were hand transplanted with 3 plants each hill on 13 June.Hills and rows were 16.7 and 30 cm apart,respectively(equivalent to 24 hill m-2).Three levels of N application were: 150kg/hm2(low,LN),250kg/hm2(medium,MN) and 350kg/hm2(high,HN).To calculate the days of main growth duration of in both ambient and FACE plots,10 hills per experiment plot were selected and marked to investigate leaf age.Results showed that: the mean days from sowing to heading,from heading to maturity and the whole growth duration of shortened 3-4.5d(mean value 3.4d),2-3d(mean value 2.4d) and 5-7.5d(mean value 5.8d) in FACE treatment compared with CK.Increasing of nitrogen application rate could weaken the effect of FACE on growth duration.In order to describe these changes and predict the growth duration of rice,we developed a growth duration model of in FACE condition based on the rice clock model.The factor of N contents in plants was introduced to adjust the growth duration model in FACE rice.The model was tested with different experimental data and the errors between simulated days and observed days in the CK and FACE conditions were small,with the RMSE in different growth duration from the biggest 2.64d to the smallest 0.15d.The results showed that the growth duration model in FACE was not only accurate but also applicable.

Topic: Plant responses to elevated CO2
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Scoliosis in familial dysautonomia.

Scoliosis is an almost constant finding in patients with familial dysautonomia who survive their first few years. Spinal deformity is frequently progressive and can add a serious problem to the complicated disease with its already high morbidity and mortality. Because of the associated physiological disturbances, conservative treatment frequently does not control the problem and surgery by spine fusion is indicated. Our experience suggests that the operative should be performed relatively early, before the appearance of a major curvature.

Topic: Hereditary Neurological Disorders
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Techno-Globalism and Techno-Nationalism: an Interpretative Framework

This paper adopts a “geography of innovation” approach to test for France the hypothesis that patent activity within each administrative region is related to corporate expenditures in R&amp;D in that territory, as well as research expenditures undertaken in universities located in the same area. It emerges that French manufacturing firms (both private and state-owned) benefit significantly from knowledge produced within the geographical area in which they are located, although the coefficient estimated for the university R&amp;D variable is equally significant but higher than that for the industry R&amp;D one. At the reginal level, university research therefore turns out to be the most crucial source of knowledge spillovers for the innovative activities of manufacturing firms.

Topic: University-Industry-Government Innovation Models
Subfield: Management of Technology and Innovation
Field: Business, Management and Accounting
Domain: Social Sciences
Supercapacitor-Based Hybrid Energy Harvesting for Low-Voltage System

This research provides a platform for a novel innovative approach toward an off-grid energy harvesting system for Maglev VAWT. This stand-alone system can make a difference for using small-scale electronic devices. The configuration presents a 200 W 12 V 16 Pole AFPMSG attached to Maglev VAWT of 14.5 cm radius and 60 cm of height. The energy harvesting circuit shows better efficiency in charging battery in all aspects compared to direct charging of battery regardless with or without converter. Based on analysis and results carried out in this research, all feasibility studies and information are provided for the next barrier.

Topic: Wireless Power Transfer Systems
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Imaginary Companions of School Boys and Boys with Dissociative Identity Disorder/Multiple Personality Disorder: A Normal to Pathologic Continuum

Adults with dissociative identity disorder/multiple personality disorder often describe having had very vivid imaginary companions in childhood. Little is known, however, about the phenomenon of imaginary companions in children with dissociative disorders. This article explores differences in the number, nature, and functions of imaginary companions of abused, severely dissociative boys and of normal school boys.

Topic: Psychosomatic Disorders and Their Treatments
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Atrial Tachycardia or Long RP Supraventricular Tachycardia!

The above electrocardiogram (ECG) was obtained in a patient with intermittent palpitations. The rhythm reveals regular narrow-QRS complex tachycardia at 133 beats per minute (BPM) as indicated by the green arrows in the rhythm strip. The atrial rhythm consists of negative P waves in the inferior leads, II, III and aVF, fusing with the T waves (red arrows) suggestive of a non-sinus origin. The initial impression, also suggested by the EKG machine automated reading, was atrial tachycardia. Closer scrutiny, however, of the P waves reveals that they are absent (blue stars) before the 8th and 14th QRS complexes. The absence of P waves despite the persistence of the QRS complexes makes atrial tachycardia highly unlikely, in which case a dropped atrial beat would be expected to result in a dropped QRS complex as well. Therefore, a more plausible explanation is that the rhythm is actually junctional or supraventricular tachycardia (SVT) with retrogradely conducted P waves and a long RP interval, with intermittent lack of VA conduction causing the dropped atrial beats.

Topic: Cardiac Arrhythmias and Treatments
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Occurrence Download

A dataset containing 114 species occurrences available in GBIF matching the query: { "and" : [ "TaxonKey is Cirsium arvense", "Country is India", "HasCoordinate is true" ] } The dataset includes 114 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0091708-250717081556266/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.

Topic: Silymarin and Mushroom Poisoning
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
[Prevalence of hepatitis B virus core promoter mutant isolated from asymptomatic carriers from areas with higher and lower incidence of hepatocellular carcinoma in Guangxi].

These data implicated that the prevalence of HBV core promoter mutant isolated from asymptomatic carriers may not be correlated with the incidence of HCC in Guangxi.

Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Flexible interface migration

The goal of this work is to provide users immersed in a multi-platform environment with the possibility of interacting with an application while freely moving from one device to another. We describe the solution that we have developed for a service to support platform-aware runtime migration for Web applications. This allows users interacting with an application to change device and continue their interaction from the same point. The service performs the migration of the application taking into account its runtime state and adapting the application interface to the features of the target platforms. The service is optimized for applications developed through a modelbased, multiple-level approach. The intelligence of the adaptive interfaces resides in the migration server, which adapts data collected at runtime from their original format to the format best fitting the features of the target platform. We also indicate how it is possible to extend this result in order to support partial migration and synergistic access, by which a part of the user interface is kept on one device during runtime and the remaining part is moved to another with different characteristics.

Topic: Business Process Modeling and Analysis
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Distributive multi-sensor data fusion with state equality constraints

The state estimation technique for the distributed multi-sensor data fusion with state equality constraints is described theoretically.Based on single Kalman filtering equations and the distributed multi-sensor fusion algorithm without state constraints, and taking state equality constraints into consideration,a new fusion estimation algorithm for distributed multi-sensor with state equality constraints is proposed.The mathematical properties of the new fusion algorithm are given and proved,also.

Topic: Target Tracking and Data Fusion in Sensor Networks
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Utilizing Brief Spiritual Assessments with Clients who belong to the Church of Jesus Christ of Latter-day Saints:

In recent years social work has increasingly focused on spirituality and religion as key elements of cultural competency. The Joint Commission—the nation's largest health care accrediting organization—as well as many other accrediting bodies require spiritual assessments in hospitals and many other mental health settings. Consequently, specific intervention strategies have been fostered in order to provide the most appropriate interventions for religious clients. The Church of Jesus Christ of Latter-day Saints is the fourth largest and one of the faster growing churches in the United States. In an effort to facilitate cultural competence with clients who are members of the Church of Jesus Christ, a brief spiritual assessment instrument was developed. This mixed-method study asked experts in Church culture (N = 100) to identify the degree of cultural consistency, strengths, and limitations of the brief spiritual assessment instrument. Results indicate that the framework is consistent with Church culture and a number of practice-oriented implications are offered.

Topic: Religion, Spirituality, and Psychology
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Does the aspiration of lamp oil increase the alveolar diffusion barrier for oxygen? proving clinical findings in an in-vitro alveolar space chamber experiment

Background: Based on a Federal Institute for RiskAssessment (BfR) detailed analysis (57,093 reports between 1990-2008) of aspiration cases with liquid preparations, the aspiration risk is clearly associated with the ingestion of distinct aliphatic hydrocarbons with a chain length from C8 to C16. These are the main compounds of paraffin-containing lamp oils, grill lighters and kerosene. Based on their typical lowviscosity, low surface tension and low vapour pressure these substances can enter the deep spaces of the lung. More than 320 serious cases and five deaths of children have been documented in the BfR since 1990 with the typical signs of lack of oxygenation, giving strong clinical indications for an oxygen intra-alveolar diffusion barrier effect. To prove this hypothesis, the intraalveolar surface and the oxygen transfer was simulated in an in vitro Alveolar Space Chamber (ASC) experiment. Methods: A gas-tight Plexiglass-measuring chamber (diameter 115 mm, height 115 mm, wallthickness 15 mm) was half-filled with fluorocarbon(FC-43) to generate a liquid-gas surface to simulate the alveolar surface. The oxygen-transport through the surface was measured in the bottom liquid part of the chamber by a Unisense oxygen micro sensor,connected to a high-sensitivity Pico-ammeter. Results:The results of the experiments revealed that the alveolar surfactant can be considered as a strong accelerator to the oxygen transfer into the liquid space of the capillary lung system. In contrast to these findings, generated microfilms of lamp oils reduce the transfer of oxygen through the surface to a high extent (minimum 9-15fold). Transferring these findings to the clinical course of the documented serious lamp oil aspiration, the ASC-experiment could give clear indications of the pathophysiological mechanism. The characteristic physico-chemical properties of ingested lamp oils gives these liquids the capacity to spread deep into the lung, and finally into the alveolar spaces with the effect of building up a persistent diffusion barrier for oxygen.This could explain the severe asphyxia and deathd ocumented in BfR cases. Conclusion: The ASC experiment gives a plausible understanding of the clinical findings in cases of serious lamp oil aspirations.The experiment is currently being extended to find new additional therapeutic tasks in cases of severe aspiration.

Topic: Airway Management and Intubation Techniques
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Toward a linguistic anthropological approach to listening: An ear with power and the policing of “active listening” volunteers in Japan

Abstract This article develops the concept of an ear with power. An ear with power works through listeners who can, by listening, alter people's speech and other actions. It does so in ways that suit the institutions on whose behalf the listener acts. Unlike approaches focused on the effects of listening in interactions, an ear with power is a triadic relation in process, requires listening to listeners, and shows how absent listeners affect social relations. The article traces the implications of a complaint filed against Buddhist “active listening” volunteers in Japan after the 2011 disasters. Despite not using “Buddhist language” while volunteering, they were reported for “religious‐sounding speech,” which led to the temporary hiatus of their volunteer activities. Analyzing the distributed listening that led to that censure, this article demonstrates how linguistic anthropology might reframe critical analyses of power and governance, which have tended to rely on vision and speech. More specifically, it considers the ramifications of acts of listening that precede the speech that they are imagined to follow, the process whereby listeners come to hear themselves through the ear of another, and the ways that policing listening can alienate listening from listeners.

Topic: Language, Discourse, Communication Strategies
Subfield: Language and Linguistics
Field: Arts and Humanities
Domain: Social Sciences
Endogenous Coalition Formation in Rivalry

This paper studies endogenous coalition formation in an environment where con tinuing con ict exists A number of players compete for an indivisible prize and the probability of winning for a player depends on his initial resource as well as the dis tribution of initial resources among the other players Players can pool their resources together to increase their probabilities of winning through coalition formation If a coalition wins the players in the coalition will further compete and possibly form new coalitions The game continues until one individual winner is left We determine sub game perfect equilibria for the game of three or four players and provide conditions under which the equilibrium coalition structures involve a balance of power We also illustrate that there can be no equilibrium coalition structure Our analysis sheds some lights on problems of temporary cooperation among heterogeneous individuals who are rivals in nature

Topic: Game Theory and Voting Systems
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
A single-server system with limited service policy

The exhaustive limited service system, in which the processor takes a preventive maintenance after every M messages are processed, is considered. The probability-generating function of the number of messages in the system and the distribution of the message delay time are derived. From these the average number of messages in the system and the mean delay time of messages are easily obtained.

Topic: Advanced Queuing Theory Analysis
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Synthesis of 5-arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-arylmethyl-5-phenyl-2-thioxoimidazolidin-4- one) via the reaction of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone and urea (or thiourea) was carried out in 57-98% yields at 50 °C in EtOH in the presence of KOH under ultrasound irradiation. The procedure has the advantages of mild conditions, short reaction time and high yield. Keywords: Substituted hydantoin, synthesis, chalcone oxide, ultrasound irradiation, seizures, convulsions, epoxyl, methoxyphenyl, propanone, imidazolidine

Topic: Synthesis and Characterization of Heterocyclic Compounds
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences