jimnoneill/paper-to-field-training huggingface dataset:
Factors Influence Knowledge Sharing Through Social Networking Site Case Study: Virtual Community Institut Ibu Profesional (IIP)

The capacity that needs to be improved in a woman is one of her main tasks as a mother who educates her children. The Professional Mother Institute (IIP) is a virtual community that empowers women to become professional mothers. IIP has expanded the community to various cities and countries, and has also won many awards. But in the last batch there has been decline significantly in the numbers of members along with applying code of conduct in an effort for IIP members can always participate actively in knowledge sharing. Beside that, as far as we know, no one has discussed the factors that influence knowledge sharing in a virtual community that empowers mothers. Therefore, researchers are encouraged to explore what factors influence knowledge sharing at IIP which uses the Social Networking Sites (SNS) as one of them whatsapp. This research can contribute to IIP by providing input on how IIP makes members keep active in sharing knowledge and keep on increasing. Other than that, this certainly can be a learning for other virtual communities. The method of collecting data in this study used an online questionnaire that was distributed to IIP members of the class "Bunda Sayang". This data collection received a response of 115 valid respondents. This data then processed with PLS SEM. The results of this study are perceived reciprocal benefit factors, Perceived enjoyment, Perceived status and Outcome expectation have a positive effect on knowledge sharing in whatsapp group IIP members. Future research can raise other factors or see the impact of knowledge sharing by women in virtual communities, especially those related to community empowerment.

Topic: Knowledge Management and Sharing
Subfield: Communication
Field: Social Sciences
Domain: Social Sciences
VILLAGE OF WISDOM: UNDERSTANDING HOW PARENTS OF AFRICAN AMERICAN BOYS HELP THEIR CHILDREN NAVIGATE RACIAL BIAS TO ACADEMIC SUCCESS

This study examined how parents understand the experiences, resources, and situations that inform how they approach racial socialization with their pre-adolescent Black sons. Using qualitative analysis and leveraging a phenomenology-informed approach, I explored the psychological world of beliefs, identities, perspectives, emotions and experiences of parents. In this study, I revealed an understanding of the thought processes that precede the complex mix of messages parents share with their young boys about race. I also sought to determine how school situations contributed to or facilitated parent conversations with children about race. Parents indicated that older siblings, school-based incidents of racial bias, extended family, school lessons on diversity, and other factors impacted their racial socialization conversations. A process model of racial socialization emerged from the analysis of the data collected from parents in this study. This study adds to the research literature by identifying new factors that impact parent racial socialization and developing a richer understanding of known factors, processes and strategies that guide parent racial socialization.

Topic: Early Childhood Education and Development
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
On increasing of the competitiveness of the garment industry in Siberian federal district on the basis of the industrial cluster establishment

The issue of the development prospects of the Russian economy and the economy of its individual branches in the regions is highly relevant in terms of the increasing crises and economic development challenges. The scope of the study is a garment industry of the Siberian Federal District, which includes 12 subjects, and only six of them develop the garment industry actively. There are the regions of Kemerovo, Novosibirsk, Omsk, Tomsk, Krasnoyarsk Krai and the Republic of Khakassia. The subject matter of the research is the state and prospects of the garment industry of the Siberian Federal District. It also includes the assessment of the garment industry as one of the sub-sectors of the light industry in terms of its competitiveness in the domestic market. The purpose of the comprehensive study is to determine the conditions and factors affecting the development of the industry, as well as to identify its development reserves and competitiveness on the basis of industrial cluster’s generation. The hypothesis of this study is that in the Siberian Federal District, there are a need and reserves to create a cluster of the garment industry. The main methods of the study are the comparative analysis, the expert assessment of the sector in certain regions of the Siberian Federal District, as well as the assessment of possible formation of the industrial cluster in the region. The results of the study are the evaluation of the competitiveness and prospects of the garment industry in Russia and the Siberian Federal District (a low level of development and competitiveness); the evaluation of the development level of the garment industry in the Federal District, which have showed the demand for apparel products from the population and enterprises, as well as the conditions for the provision of clothing manufacture with natural fabrics and synthetic materials, labor resources and research and development achievements; also the justification of the existing potential for development of a sectoral cluster by means of pooling together the productions and economic communications of the Novosibirsk and Omsk regions at the initial stage. The obtained results should be used to strengthen works for the development of regional industrial cluster (with a creation of a working group at the regional governments, the garment industry development programs, and practical measures for its realization), as well as a creation of conditions for stimulation of investment activity of entrepreneurs. The research has confirmed the hypothesis, that in the Siberian Federal District, there are a need and reserves to create a cluster of the garment industry.

Topic: Regional Economic Development and Innovation
Subfield: Strategy and Management
Field: Business, Management and Accounting
Domain: Social Sciences
Municipal law

In the context of WTO jurisprudence, the term ‘municipal law’ is used interchangeably with the terms ‘national law’ and ‘domestic law’, in the same way that one finds these terms being used interchangeably elsewhere. WTO adjudicators have been confronted with a range of different issues relating to municipal law, one reason being that many of the measures challenged in WTO dispute settlement proceedings are municipal laws. The WTO agreements contain some specific provisions that speak to the relationship between those agreements and municipal law. For instance, Article XVI:4 of the WTO Agreement establishes that ‘[e]ach Member shall ensure the conformity of its laws, regulations and administrative procedures with its obligations as provided in the annexed Agreements’, and a small number of provisions in the covered agreements establish a ‘renvoi’ to each Member's national law to define certain terms. Otherwise, when confronted with questions relating to municipal law, WTO adjudicators have often fallen back on general international law concepts and principles of wider applicability. This chapter reviews WTO statements of wider applicability relating to: (i) the relevance of municipal law concepts and classifications to treaty interpretation; (ii) the invocation of municipal law as a justification for a failure to perform a treaty obligation; (iii) alleged violations of municipal law; (iv) the interpretation of municipal law by international tribunals; (v) the implementation of international obligations in municipal law; and (vi) representations made by a State regarding the operation of its municipal law.

Topic: World Trade Organization Law
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Observation of distinct atomic relaxation process in a phase-separated metallic glass-forming melt

We have investigated the atomic relaxation processes in phase-separated alloy melts using quasielastic neutron scattering. Among the three alloy melts studied (<em>i.e.</em>, Al<sub>30</sub>Cu<sub>20</sub>Sn<sub>50</sub>, Al<sub>30</sub>Cu<sub>30</sub>Sn<sub>40</sub> and Y<sub>28</sub>T<sub>i28</sub>Al<sub>24</sub>CO<sub>20</sub>), Y<sub>28</sub>Ti<sub>28</sub>Al<sub>24</sub>CO<sub>20</sub> is not only a phase-separated melt but also vitrified upon quenching. In this glass-forming melt, we have observed dissimilar relaxation processes in the different phases of the melt: a collective atomic transport process in the phase that exhibits a slow relaxation process and an atomic jump diffusion process in the phase that displays a fast relaxation process. Interestingly, the temperature dependence of the diffusion process in the former phase is a non-Arrhenius process, which is similar to that observed in many fragile glass-forming liquids. In contrast, the temperature dependence of the diffusion process is an Arrhenius process in the later phase, which is a characteristic of non-glass-forming simple liquids.

Topic: Metallic Glasses and Amorphous Alloys
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Evaluation of multiplexing and buffer policies influence on VoIP conversation quality

This work presents a study of RTP multiplexing schemes, which are compared with the normal use of RTP, in terms of ITU R-factor quality estimator. The bandwidth saving of the different schemes is studied, and some tests with VoIP traffic are carried out in order to compare R-factor using three different router buffer policies. Network delays are added using an adequate statistical distribution. The tests show the bandwidth savings of multiplexing, and also the importance of the packet size with time-limited buffer policies. The customer experience improvement which can be achieved is measured in terms of R-factor, showing that the use of multiplexing can be interesting in some scenarios, like an enterprise with different offices connected via Internet.

Topic: Network Traffic and Congestion Control
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
The Response of a Liquid to Relative Forces With Application to Electro migration

Abstract We discuss the motion of the particles of a liquid under the influence of driving forces depending on the relative positions of pairs of particles. We show that generalized reciprocal relations exist which relate the response to velocity distributions around a diffusing particle. The theory is applied to the electro migration of a K impurity in Na, where hitherto the configuration dependence of the driving forces has been ignored. We approximate as simply as possible, the new element in the calculation being to recognize that solvent ions in the vicinity of the impurity will suffer different driving forces from those in the bulk of the fluid, and this will directly influence the impurity migration. Our calculations indicate this to be of considerable importance. We also indicate how results relating diffusion coefficients to current-current correlation functions, of a type obtained previously be a velocity-field approach, may be obtained from the present formalism.

Topic: Thermodynamic properties of mixtures
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
An Approach of Gene Regulatory Network Construction Using Mixed Entropy Optimizing Context-Related Likelihood Mutual Information

We propose a gene regulatory network construction method based on mixed entropy optimization context-relevant likelihood mutual information (MEOMI). Firstly, the mutual information between genes was calculated based on the combination of two entropy estimators, and then the distribution was optimized by the likelihood algorithm (CLR) to eliminate some indirect regulation relations, and the initial gene regulation network was obtained. In order to reflect the relationship between the complex interactions between genes and eliminate redundant edges in a gene regulatory network, this method is given by calculation of multiple gene under the conditions of the interaction between the two genetic information (CMI2) to adjust the initial gene regulatory network, continuously updated network to perfect the indirect regulating the relationship between genes, reduce the mutual information overestimated the impact of the strength of direct regulation.

Topic: Gene Regulatory Network Analysis
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Guardians of the Genome: BRCA2 and Its Partners

The tumor suppressor BRCA2 functions as a central caretaker of genome stability, and individuals who carry BRCA2 mutations are predisposed to breast, ovarian, and other cancers. Recent research advanced our mechanistic understanding of BRCA2 and its various interaction partners in DNA repair, DNA replication support, and DNA double-strand break repair pathway choice. In this review, we discuss the biochemical and structural properties of BRCA2 and examine how these fundamental properties contribute to DNA repair and replication fork stabilization in living cells. We highlight selected BRCA2 binding partners and discuss their role in BRCA2-mediated homologous recombination and fork protection. Improved mechanistic understanding of how BRCA2 functions in genome stability maintenance can enable experimental evidence-based evaluation of pathogenic BRCA2 mutations and BRCA2 pseudo-revertants to support targeted therapy.

Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A preliminary report on Advanced Microwave Precipitation Radiometer measurements of tropical rainfall of cyclone Oliver

The Advanced Microwave Precipitation Radiometer (AMPR) was deployed during the Tropical Ocean Global Atmosphere (TOGA) Coupled Ocean-Atmospheric Response Experiment (COARE) from January 4 to February 24, 1993. The passive microwave signatures of a variety of precipitation features were sampled by the AMPR during this time. These data are used for convection and precipitation studies supporting the goals of NASA's Mission to Planet Earth. On February 8, 1993, the AMPR was flown over tropical cyclone Oliver which developed in the Western Pacific Ocean off the east coast of Townsville, Australia. The results of measurements indicated heavy rain within the eyewall of the cyclone as shown in the 10.7 GHz imagery, with precipitation size ice displaced down-shear (away from the eye) in the sloping eyewall.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Topic: Tropical and Extratropical Cyclones Research
Subfield: Atmospheric Science
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Dominican Legendaries and the Legenda Aurea

The Dominican legendaries composed in the thirteenth century include Bartolomeo da Trento's Liber Epilogorum in Gesta Sanctorum, Jean de Mailly's Abbreviatio in Gestis et Miraculis Sanctorum, and Jacob of Voragine's Legenda Aurea, or Golden Legend. Bartolomeo da Trento emphasizes the maternal aspects of Perpetua, while Jean de Mailly and Jacob of Voragine return to the late antique Acta Perpetuae as their source, removing any empathic elements of Perpetua's character, and instead, representing her as an unattainable ideal, suitable for admiration but not imitation. The Golden Legend was a wildly popular book in the later Middle Ages, and as a result, the version of Perpetua's story told by Jacob of Voragine becomes the dominant one for the next 250 years.

Topic: Medieval Literature and History
Subfield: Classics
Field: Arts and Humanities
Domain: Social Sciences
Data from MicroRNA Regulation of Oncolytic Adenovirus 6 for Selective Treatment of Castration-Resistant Prostate Cancer

&lt;div&gt;Abstract&lt;p&gt;Almost all patients with advanced prostate cancer progress to castration-resistant stage with limited treatment options. Oncolytic adenoviruses have been actively pursued as potential agents for cancer treatment. Virtually all clinical trials on oncolytic adenovirus are based on serotype 5. However, viral replication in hepatocytes induces severe liver toxicity and limits its systemic administration for metastatic disease. Moreover, rapid clearance of viral particles injected intravenously further hinders the anticancer efficacy. Adenovirus 6 (Ad6) was previously reported to exhibit less liver toxicity and escape Kupffer cells absorption after systemic administration. To further improve its safety, we generated a novel oncolytic adenovirus Ad6miR, in which four copies of binding sites of a liver-specific microRNA miR122 were incorporated into E1A gene of Ad6. miR122 regulation significantly decreased Ad6 replication in hepatocytes and consequently hepatotoxicity because of the negative regulation of miR122. Cytotoxicity assay using primary or established prostate cancer cell lines showed robust oncolytic activity of Ad6miR. Systemic treatment of established tumors with Ad6miR showed strong antitumor activity, comparable with that of Ad6 or Ad5. Although Ad6 evaded Kupffer cells, its blood clearance rate was as rapid as Ad5. The vast majority of Ad6 particles intravenously injected localized in liver sinusoidal endothelial cells rather than previously reported Kupffer cells. Elevating Ad6miR injection dose increased circulating Ad6miR concentration and its antitumor efficacy. miR122 regulation of Ad6 significantly improves its safety profile after systemic administration, which allows increasing therapeutic doses leading to improved anticancer efficacy of systemic treatment of castration-resistant prostate cancer. &lt;i&gt;Mol Cancer Ther; 11(11); 2410–8. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;

Topic: Virus-based gene therapy research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity

Abstract Triple negative breast cancer (TNBC) is a most aggressive type of breast cancer without effective therapies. Cyclodextrin, a cyclic oligosaccharide is used as drug delivery carrier with cholesterol lowering property. However, whether cyclodextrin can inhibit the proliferation and migration of TNBC as well as the underlying mechanisms are unclear. In the present study, we demonstrated that 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) inhibited the growth and metastasis of TNBC both in vitro and in vivo . Meanwhile, the antitumor effects of HP-β-CD were also observed in a mouse melanoma model. Mechanistically, we initially determined that cholesterol supplementation can attenuate HP-b-CD-inhibited TNBC growth and metastasis both in vitro and in vivo . In vivo , HP-β-CD promoted the infiltration of T cells into the tumor microenvironment (TME) and improved exhaustion of CD8 + T cells via reducing endoplasmic reticulum (ER) stress and immune checkpoint molecules. Additionally, HP-β-CD inhibited the recruitment of tumor associated macrophages to the TME via reducing CCL2-p38MAPK-NF-kB axis. HP-β-CD also inhibited the epithelial mesenchymal transition (EMT) of TNBC cells mediated by transforming growth factor-b (TGF-b) signaling pathway. In summary, the data in the current study suggest that HP-β-CD effectively inhibited proliferation and metastasis of TNBC and melanoma, highlighting HP-β-CD may be a potential general antitumor clinical drug.

Topic: Cancer Research and Treatments
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Subcellular compartmentalization of the plant antioxidant system: an integrated overview

The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized forms) and thioredoxin/glutaredoxin systems which can serve as reducing agents for antioxidant enzymes. The number of genes encoding AOS enzymes varies between classes, and same class enzymes encoded by different gene copies may have different subcellular localizations, functional loads and modes of evolution. These facts hereafter reinforce the complex nature of AOS regulation and functioning. Further studies can describe new trends in the behavior and functioning of systems components, and provide new fundamental knowledge about systems regulation. The system is revealed to have a lot of interactions and interplay pathways between its components at the subcellular level (antioxidants, enzymes, ROS level, and hormonal and transcriptional regulation). These facts should be taken into account in further studies during the AOS modeling by describing the main pathways of generating and utilizing ROS, as well as the associated signaling processes and regulation of the system on cellular and organelle levels, which is a complicated and ambitious task. Another objective for studying the phenomenon of the AOS is related to the influence of cell dynamics and circadian rhythms on it. Therefore, the AOS requires an integrated and multi-level approach to study. We focused this review on the existing scientific background and experimental data used for the systems biology research of the plant AOS.

Topic: Plant Stress Responses and Tolerance
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
[Induction of apoptosis in human hepatoma cell line SMMC7721 by Newcastle disease virus HN gene].

Significant apoptosis in SMMC7721 cells can be induced by NDV HN gene. Apoptosis may be resulted from the decrease of mitochondrial trans-membrane potential and activation of Caspase-3.

Topic: Virus-based gene therapy research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Distribution of Epstein-Barr Virus and Human Herpesvirus 8 Co-Infections among Human Immunodeficiency Virus -1 Positive Patients

Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV andHHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAART) regimen compared with naïve patients. Materials and Methods: A cross-sectional study was conducted on 103 HIV-1 positive patients who attended the hospitals affiliated with the Iran University of Medical Sciences, in Tehran, Iran, from 2018 to 2019. Enzyme-linked immunosorbent assay (ELISA) test was performed to evaluate HHV-8 and EBV antibodies. A conventional polymerase chain reaction (PCR) was carried out on saliva samples to detect EBV infection and a nested-PCR assay for HHV-8 infection. SPSS (version 20) was used for statistical analysis. Results: Patients' mean age ± SD was 43.9 ± 16 (range 18-82 years), and from among 103 participants, 59 (57.3%) were male. The results of PCR showed that HHV-8 infection was found in 19 (18.4%), and EBV infection was found in 61 (59.2%) participants. Also, HHV-8 antibody was detected in 73 (70.9%), and EBV antibody in 97 (94.2%) patients. A significant association was observed between patients under treatment with HAART and HHV-8 DNA or EBV DNA infection in saliva. Conclusions: HIV-infected patients demonstrated a remarkable rate of EBV and HHV-8 in saliva, which could have a great role in the shedding of viruses. Also, they may contribute to the establishment of further opportunistic infections and devastating complications.

Topic: Viral-associated cancers and disorders
Subfield: Oncology
Field: Medicine
Domain: Health Sciences