jimnoneill/paper-to-field-training huggingface dataset:
Data from KIT&lt;sup&gt;low&lt;/sup&gt; Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor

&lt;div&gt;Abstract&lt;p&gt;Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic &lt;i&gt;KIT&lt;/i&gt; mutations that are effectively targeted by imatinib (IM), a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST, and adjuvant therapy only delays recurrence in high-risk tumors. We hypothesized that GIST contains cells with primary IM resistance that may represent a reservoir for disease persistence. Here, we report a subpopulation of CD34&lt;sup&gt;+&lt;/sup&gt;KIT&lt;sup&gt;low&lt;/sup&gt; human GIST cells that have intrinsic IM resistance. These cells possess cancer stem cell-like expression profiles and behavior, including self-renewal and differentiation into CD34&lt;sup&gt;+&lt;/sup&gt;KIT&lt;sup&gt;high&lt;/sup&gt; progeny that are sensitive to IM treatment. We also found that TKI treatment of GIST cell lines led to induction of stem cell–associated transcription factors (&lt;i&gt;OCT4&lt;/i&gt; and &lt;i&gt;NANOG&lt;/i&gt;) and concomitant enrichment of the CD34&lt;sup&gt;+&lt;/sup&gt;KIT&lt;sup&gt;low&lt;/sup&gt; cell population. Using a data-driven approach, we constructed a transcriptomic-oncogenic map (Onco-GPS) based on the gene expression of 134 GIST samples to define pathway activation during GIST tumorigenesis. Tumors with low KIT expression had overexpression of cancer stem cell gene signatures consistent with our &lt;i&gt;in vitro&lt;/i&gt; findings. Additionally, these tumors had activation of the Gas6/AXL pathway and NF-κB signaling gene signatures. We evaluated these targets &lt;i&gt;in vitro&lt;/i&gt; and found that primary IM-resistant GIST cells were effectively targeted with either single-agent bemcentinib (AXL inhibitor) or bardoxolone (NF-κB inhibitor), as well as with either agent in combination with IM. Collectively, these findings suggest that CD34&lt;sup&gt;+&lt;/sup&gt;KIT&lt;sup&gt;low&lt;/sup&gt; cells represent a distinct, but targetable, subpopulation in human GIST that may represent a novel mechanism of primary TKI resistance, as well as a target for overcoming disease persistence following TKI therapy.&lt;/p&gt;&lt;/div&gt;

Topic: Gastrointestinal Tumor Research and Treatment
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Study of microvia failure under PCB flexing loads

This paper presents a study on microvia failure caused by mechanical flexing of a printed circuit board (PCB) assembly. Cross sectioning is perfonncd to dctcnnine the failure modes and failure locations. For the samples tested. failure is found to occur as a result of de1;nnination of the microvia joints from the PCB corc. An analysis of tlie load-dcflcction curves togerhcr with finite element (FE) inodcling is used to funher understand this vpe of nucrovia hilum For different bending conditions, there is a connuon trend of failure at the joint

Topic: Electronic Packaging and Soldering Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
The Influence of Tabletop Technology in Full-Service Restaurants

This chapter underscores that tabletop technology impacts restaurant operations and guest experiences, with benefits such as improved table-turn time, labor savings, and increased guest checks. It explains that reducing table-turn time allows operators to serve more guests and potentially generate significant additional revenue. It also shows that guests appreciate having more control over the service experience, especially during the payment process. The chapter implies how tabletop technology can lead to labor efficiency by freeing up servers to either improve attention to guests or manage more tables. It presents one study using pre- and post-implementation data from a single restaurant and another study using point-of-sale data across multiple locations to examine the influence of tabletop technology on table-turn time, labor usage, and purchasing behavior.

Topic: Consumer Retail Behavior Studies
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
Two-dimensional (2D) transition metal dichalcogenide semiconductor field-effect transistors: the interface trap density extraction and compact model

A surface potential-based low-field drain current compact model is presented for two-dimensional (2D) transition metal dichalcogenide (TMD) semiconductor field-effect transistors that takes into account the effect of interface trap states on device current–voltage (Ids–Vgs) characteristics and transconductance gm. The presence of interface trap states detrimentally affects device Ids–Vgs performance. Minimal work exists on the extraction of trap states (cm−2 eV−1) of MoS2/high-K dielectric/metal-gate stacks. Additionally, there is a lack of compact models for 2D TMD MOSFETs that can take into account the effect of trap states on device Ids–Vgs performance. This study presents a method to extract the interface trap distribution of MoS2 MOSFETs using a compact model. Presented as part of the model is a surface potential/interface trap charge self-consistent calculation procedure and a drain current expression that does not need numerical integration. The model is tested against reported experimental Ids–Vgs data, and excellent agreement is found between the experiment and the model.

Topic: 2D Materials and Applications
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Designing Task-Based English Speaking Materials for the Staff of Bank Mandiri Yogyakarta

Most of the staff of Bank Mandiri in Yogyakarta have some difficulties to communicate with the foreign customers, which hinder the process of the service. Therefore, this study attempted to develop English speaking materials for the staff of Bank Mandiri in Yogyakarta using the principles of task-based learning. The writer adapted Kemps instructional design model (1977) comprising eight flexible, interdependent steps. Those steps, subsequently, were put under the umbrella of Borg Galls (1986) Research and Development (RD) method. Due to time and resource limitations, only three out of ten steps of the RD model were employed, which were: (1) Research and information collecting, (2) Planning and (3) Developing preliminary form of product. To acquire required information for developing the materials, the writer distributed needs analysis questionnaire to twenty staff of Bank Mandiri, Yogyakarta. The designed materials covered eight units. Each unit consisted of five sections, namely Do You Remember?, Prepare Yourself!, Can You Do These?, Lets Learn!, and Its Time to Write. It was expected that the materials could improve the speaking skill of the staff of Bank Mandiri Yogyakarta.DOI: https://doi.org/10.24071/llt.2017.200108

Topic: English Language Learning and Teaching
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Segmental diastolic compression of circumflex coronary artery secondary to pericardial constriction: an uncommon cause of angina pectoris.

Diastolic segmental compression of a native coronary artery is an uncommon cause of chest pain. Here we describe a 24-year-old woman with constrictive pericarditis who had retrosternal chest pain, progressive dyspnea, tachycardia, and bilateral leg edema. She was diagnosed with compression of the first and second obtuse marginal branches of left circumflex coronary artery secondary to constrictive pericarditis. She underwent pericardiectomy and her symptoms were relieved following surgery.

Topic: Pericarditis and Cardiac Tamponade
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Development of oxide-based all-solid-state batteries using aerosol deposition

ABSTRACTAerosol deposition (AD) is a ceramics coating technology that can be used at room temperature. AD does not use organic binders for the ceramics coating process, which reduces the amount of exhaust carbon dioxide. Additionally, AD realize fast and wide-area ceramics coating without heating the substrate. Thus, AD is an environmentally friendly ceramics coating process. AD has been already applied to various research fields including energy conversion devices such as rechargeable lithium-ion batteries and solid oxide fuel cells. Unique properties of AD are effective to investigate the fundamental properties of oxide-based all-solid-state batteries (Ox-SSBs) and possibly their productions. This paper reviews developments of Ox-SSBs using AD, mainly presenting our research.

Topic: Catalytic Processes in Materials Science
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
[Indications for urodynamic studies before and after adenomectomy].

Preoperative urodynamic examinations are an important supplement to our diagnostic repertoire in cases of adenoma of the vesical cervix. Flow measurement should always be carried out. In routine practice further urodynamic examinations are only indicated in uncertain cases. Exact preoperative diagnosis will greatly improve the results of adenectomy. Persistent dysuria or incontinence are always an indication for post operative urodynamic examinations. Here efficient therapy is made possible by exact diagnosis.

Topic: Urological Disorders and Treatments
Subfield: Urology
Field: Medicine
Domain: Health Sciences
RELEVANCE OF RATER‐RATEE ACQUAINTANCE IN THE VALIDITY AND RELIABILITY OF RATINGS1

Unacquainted S s worked in three‐man groups under relevant (mathematical tasks) and irrelevant (socializing) acquaintance conditions. The S s rated one another on scales that defined several cognitive skills. They were also rated on these same scales by observers who were dependent on visual information, exclusively, and were unacquainted with the group members or the specific nature of the tasks being performed. As hypothesized, group members under the relevant acquaintance condition achieved consistently good validity for all three cognitive areas—with the best validity for ratings of math ability. Validity under the irrelevant acquaintance condition was nil on all scales. Observers, surprisingly, achieved significant validity (although at lower levels than participating group members) for ratings under the relevant acquaintance condition. Levels of inter‐ and intrarater reliability were not associated with levels of validity under the various rating conditions.

Topic: Behavioral Health and Interventions
Subfield: Applied Psychology
Field: Psychology
Domain: Social Sciences
An improved method for estimating temperature rise of a bushing loaded above nameplate rating

The authors have developed an accurate but simple method to estimate the temperature rise (referred to as "rise" hereafter) of a bushing conductor under any load condition. This method consists of one equation and two predetermined rise profiles F/sub 1/(z) and F/sub 2/(z). F/sub 1/(z) is the incremental rise profile at the rated current and F/sub 2/(z) is the normalized rise profile at zero current. F/sub 1/(z) and F/sub 2/(z) can be obtained from two base thermal tests. The proposed method allows estimation of the rise profile of the bushing under any given load condition. Therefore the rise and the location of the hottest spot can be determined from this profile. They have successfully applied this method to various bushings, such as bushings with and without oil circulation, bottom connected and draw-lead connected bushings and some special bushings with two conductors. They examined this method with a thermal circuit model and verified that the thermal model supports the new method.

Topic: High voltage insulation and dielectric phenomena
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Primary angiitis and angiopathy of the central nervous system and their relationship to systemic giant cell arteritis.

Three cases of primary angiitis of the central nervous system were compared with previously published cases. Most cases occurred in older adults, were diagnosed histologically, and had a male-female ratio of 2:1. Angiographically identified cases, demonstrating angiopathy but not necessarily vasculitis as might be seen in histologically identified cases, were found in younger adults and showed a male-female ratio of 1:2. The autopsy cases had some similarities to systemic giant cell arteritis, including many cases with vasculitis in large branches of the circle of Willis and foci of systemic vasculitis. Vasculitides in arteries of different sizes may result from different responses to a variety of antigens or immune complexes rather than represent different disease processes. If causative immune mechanisms can be identified, primary angiitis of the central nervous system may become classified immunologically rather than histopathologically.

Topic: Vasculitis and related conditions
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Waves generated by sources on expanding circular frames

This paper describes the waves formed by the sources on expanding circular frames. The solution is constructed by means of Smirnov method of incomplete separation of variables. The circular source expanding with a velocity that is greater than the velocity of light may be realized by means of the pulse of hard radiation with the conical front and the absorptive plane. The constructed scalar solutions can be used for electromagnetic waves.

Topic: Geophysics and Sensor Technology
Subfield: Ocean Engineering
Field: Engineering
Domain: Physical Sciences
Toward a treaty on safety and cost-effectiveness of pharmaceuticals and medical devices: enhancing an endangered global public good

Abstract • Expert evaluations of the safety, efficacy and cost-effectiveness of pharmaceutical and medical devices, prior to marketing approval or reimbursement listing, collectively represent a globally important public good. The scientific processes involved play a major role in protecting the public from product risks such as unintended or adverse events, sub-standard production and unnecessary burdens on individual and governmental healthcare budgets. • Most States now have an increasing policy interest in this area, though institutional arrangements, particularly in the area of cost-effectiveness analysis of medical devices, are not uniformly advanced and are fragile in the face of opposing multinational industry pressure to recoup investment and maintain profit margins. • This paper examines the possibility, in this context, of States commencing negotiations toward bilateral trade agreement provisions, and ultimately perhaps a multilateral Treaty, on safety, efficacy and cost-effectiveness analysis of pharmaceuticals and medical devices. Such obligations may robustly facilitate a conceptually interlinked, but endangered, global public good, without compromising the capacity of intellectual property laws to facilitate local product innovations.

Topic: Pharmaceutical Economics and Policy
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
CPPGAN-ESM: GAN-Enhanced ESM Prediction Model for Cell-Penetrating Peptide

Cell-penetrating peptide, with their ability to traverse cell membranes and access the intracellular environment, has garnered significant attention in contemporary medical research. Predicting cell-penetrating peptide can expand the therapeutic scope, improve the therapeutic effect, and promote the development of drug delivery, gene therapy, and other fields. Compared with the traditional wet-lab method, predicting cell-penetrating peptide by computational methods has the advantages of low cost and accuracy. However, due to the difficulty of collecting cell-penetrating peptide datasets and the performance limitation of traditional feature extractors, Predicting the performance of cell-penetrating peptide using traditional computational methods has limitations. To address these problems, a cell-penetrating peptide prediction method named CPPGAN-ESM is proposed in this paper. CPPGAN-ESM firstly augments the cell-penetrating peptide dataset by using Deep Convolutional Generative Adversarial Network, and then fine-tunes the predictor based on the Evolutionary Scale Modeling 2 pre-trained feature extractor with the augmented dataset, to realize the prediction of the cell-penetrating peptide. Extensive experiments on a public dataset show that the method achieves an efficient performance of 0.979 AUC and 0.977 ACC in the cell-penetrating peptide prediction task.

Topic: RNA Interference and Gene Delivery
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Synthesis and Characterization of Poly(Methyl Methacrylate) Grafted from Acacia Gum

Abstract Graft polymerization of methyl methacrylate onto acacia gum has been studied in detail. The grafting was found to be optimal under the following reaction conditions: gum at 0.4 g/dL, monomer at 7.52 × 10 −;2 mol/dL, ceric ammonium sulfate at 15.81 × 10 −;4 mol/dL, H 2 SO 4 at 0.037 mol/dL, temperature at 50 °C and time at 3.0 h. Fourier transform infrared spectroscopy was sed for the confirmation of grafting. Thermal and physical properties of the copolymer were studied. A probable mechanism of polymerization has been suggested based on reaction kinetics.

Topic: biodegradable polymer synthesis and properties
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
The Changing Climate of Opera—An Edwardian Recollection

Adelina Patti had made her last appearance at the Royal Opera in 1895, and her place as prima donna was taken by Nellie Melba. But Melba, although her voice was of incomparable beauty, lacked that touch of fire which a singer must have, if she is to capture the imagination of her audience; and for twelve years the throne of the Diva was vacant. Then, during the autumn of 1907, a new star of the most amazing brilliance appeared, quite unheralded.

Topic: Musicology and Musical Analysis
Subfield: Music
Field: Arts and Humanities
Domain: Social Sciences
Effect of Brown Algae (Fucus vesiculosus L.) on Humus and Chemical Properties of Soils of Different Type and Postgermination Growth of Cucumber Seedlings

The possibility of using brown algae in agriculture as an alternative source of nutrients is currentlyunder study and discussion. Our study aimed to evaluate the effect of F. vesiculosus on the agrochemical properties of four soil types: Retisol loamy sand soil, Retisolloam, Retisol clay, and Histosol. The F. vesiculosus waste was added to soil samples at a rate of 0, 0.5, 1.0, 2.0, 5.0, and 10 wt%. The brown algaewaste application significantly decreased soil acidity in the substrates of all soil types, with the larger increasesfor Retisol loamy sand and Retisol clay than for Retisol loam and Histosol. The application of F. vesiculosus waste products increased the C content in all soil types except Histosol. The N and P content in soil substrates were not significantly affected by algaewaste application regardless of soil type. This study showed that the effect of F. vesiculosus waste application varies depending on the soil type, with the strongest impact on Retisol clay and the lowest on Histosol.

Topic: Plant Growth Enhancement Techniques
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Diálogo de saberes multidisciplinario, temporada 2: El reto de la página en blanco en un proyecto de investigación

Through the Permanent Seminar for Research Dissemination or SEPEDI developed by FES Acatlán, there have been collaborative discussions on academic writing projects which enable researchers to build their self-confidence and their productivity. As part of this seminar, an event was organized to discuss the best practices in regard to the stages of a research process which helps to overcome the possible challenges that researchers face during this process.

Topic: E-Learning and Knowledge Management
Subfield: Computer Science Applications
Field: Computer Science
Domain: Physical Sciences
Is Political Science Meant for Every Tom, Dick, or Harriet? The Role of First Names and Middle Initials as Predictors of Academic Success

Abstract We take advantage of the data set compiled by Masuoka et al. (2007, PS: Political Science and Politics 40 (1): 361–66) on lifetime citation counts of political science faculty at PhD granting institutions in the United States to look for “lucky names,” that is, names parents can give babies that predispose them toward scholarly success in political science. Seeking to test an hypothesis offered by Wuffle (1972, PS: Political Science and Politics (Summer): 290), we also briefly look at the importance of middle initials for citation success in political science.

Topic: Names, Identity, and Discrimination Research
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
John Moschus and His Friend Sophronius the Sophist

Journal Article John Moschus and His Friend Sophronius the Sophist Get access H. Chadwick H. Chadwick Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume XXV, Issue 1, January 1974, Pages 41–74, https://doi.org/10.1093/jts/XXV.1.41 Published: 01 January 1974

Topic: Biblical Studies and Interpretation
Subfield: Religious studies
Field: Arts and Humanities
Domain: Social Sciences
Ferromagnetic resonance in FeCoNi electroplated wires

We have investigated the microwave properties (ferromagnetic resonance and ferromagnetic antiresonance) of FeCoNi magnetic tubes created by electroplating on CuBe wire. Important parameters such as the g factor, magnetization, anisotropy field, and damping parameter were obtained from the measurements. One sample, prepared by a method which entails rf-sputtering deposition of an additional FeNi layer, shows a clear ferromagnetic antiresonance.

Topic: Magnetic properties of thin films
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Behçet Disease with Generalized Polymorphous Cutaneous Lesions: A Case Report

Introduction: Behçet disease is a chronic multisystem vasculitis disease, however generalized polymorphous cutaneous lesions are uncommon. Here, we reported a case of Behçet disease with multiple parts of the body and complex lesions, which may lead to misjudging in clinical diagnosis. Case report: A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions (erythematous papules, nodules, ulcers, and necrosis) over his entire body, and the lesions had been painful for the past three years. Based on the past medical history, clinical presentation, histological examination excluded other diseases, and the 2014-amended International Criteria for Behget disease, the patient had a score of 6 points and was diagnosed as Behçet disease. Discussion: The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous ulcers. Other clinical manifestations of this disorder are more variable among different patients. A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other diseases. Conclusion: The mucocutaneous lesions of Behçet disease are often preceded by other manifestations, and timely diagnosis may benefit early treatment and prognosis.

Topic: Ocular Diseases and Behçet’s Syndrome
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences