jimnoneill/paper-to-field-training huggingface dataset:
Elucidating the Role of let-7d-5p and OLR1 in Progression and Prognosis of Oral Squamous Cell Carcinoma via FAK/P53 Signaling axis

Abstract Purpose: This study investigates the role of let-7d-5p microRNA (miRNA) and its target gene OLR1 in oral squamous cell carcinoma (OSCC), focusing on their implications in tumor progression, metastasis and potential as therapeutic targets. Despite advances in OSCC diagnosis and treatment, the five-year survival rate remains low, underscoring the need for improved biomarkers and therapeutic strategies. We aim to elucidate the regulatory functions of let-7d-5p and OLR1 in OSCC pathogenesis. Methods: Employing next-generation sequencing and bioinformatic tools, we profiled differentially expressed miRNAs in metastatic OSCC cell lines, identifying let-7d-5p as a key downregulated miRNA and OLR1 as a novel target of let-7d-5p. We validated this interaction using luciferase reporter assays and studied the biological effects of modulating let-7d-5p and OLR1 expression on OSCC cell proliferation, migration, invasion and stemness. Additionally, we analyzed clinical data to establish the relevance of OLR1 expression in OSCC prognosis. Results: Our findings reveal let-7d-5p as a potent suppressor of OSCC metastasis, primarily by targeting and downregulating OLR1. OLR1 -silencing reduced OSCC cell invasiveness, migration, and stemness, implicating its prominent role in tumor progression. Mechanistically, let-7d-5p modulates a signaling cascade involving FAK, SRC, PAXILLIN, and P53, influencing cellular apoptosis and chemoresistance. Clinically, elevated OLR1 expression significantly correlates with advanced OSCC stages and poorer survival rates, highlighting its potential as a prognostic marker and therapeutic target. Conclusion: Our study uncovers the significance of the let-7d-5p-OLR1 axis in OSCC pathogenesis, offering novel insights for future therapeutic interventions.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Clouded Judgment: The Role of Sentiment in Credit Origination

Using daily fluctuations in local sunshine as an instrument for sentiment, we study its effect on day-to-day decisions of lower-level financial officers. Positive sentiment is associated with higher credit approvals, and negative sentiment has the opposite effect of a larger magnitude. These effects are stronger when financial decisions require more discretion, when reviews are less automated, and when capital constraints are less binding. The variation in approval rates affects ex-post financial performance and produces significant real effects. Our analysis of the economic channels suggests that sentiment influences managers' risk tolerance and subjective judgment.

Topic: Banking stability, regulation, efficiency
Subfield: Finance
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Die Not- und Selbsthilferechte

The modern states monopoly on violence makes it difficult to justify the citizens right to use physical force in certain emergency situations. Stefan Klingbeil shows how traditional legal instruments such as the right to self-defence can be re-interpreted within the normative framework of the constitutional state.

Topic: Medical and Health Sciences Research
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
DIAGNOSA PENYAKIT KUCING PERSIA DENGAN SISTEM PAKAR MENGGUNAKAN PENDEKATAN FORWARD CHAINING

Abstract A survey conducted by Rakuten Insight Center stated that Indonesia is a cat lover, proven by 47% of cats to be the most pets, and the Persian cat breed is one of the most popular animals among people from various ages range. This advantage cannot be separated from the problem, where in 2021 the Indonesian Ministry of Health said that only 8 provinces in Indonesia were free from rabies, one of which was transmitted through cats, and other diseases that could certainly endanger the pet owner. In addition to the limited knowledge of animal owners about the types of diseases and treatment solutions, forcing animal owners to always take them to the vet at a considerable cost, the expert system created seeks to help animal owners to diagnose diseases experienced by Persian cats, namely Rabies, Kidney Failure, Panleukopenia, Feline Infection Peritonitis, and Feline Calici Virus. This study used a forward chaining approach, to validate disease and symptoms data in this study was conducted by direct interviews with veterinarians working in animal friendly clinics. The expected result of this study is how a forward chaining approach can be applied to help diagnose diseases in Persian cats. Abstrak Survei yang dilakukan oleh Rakuten Insight Center menyatakan bahwa Indonesia merupakan pencinta hewan kucing, terbukti 47% hewan kucing menjadi hewan peliharaan terbanyak, dan jenis kucing persia menjadi salah satu hewan yang populer dikalangan masyarakat dari berbagai kalangan dan usia. Kelebihan ini tidak lantas lepas dari permasalahan, dimana tahun 2021 Kementerian Kesehatan RI mengatakan hanya 8 propinsi di Indonesia yang bebas dari penyakit Rabies yang salah satunya ditularkan melalui hewan kucing, dan penyakit-penyakit lain yang tentu dapat membahayakan pemilik hewan piaraan tersebut. Disamping keterbatasan pengetahuan pemilik hewan mengenai jenis penyakit dan solusi perawatannya, memaksa pemilik hewan selalu membawa ke dokter hewan dengan biaya yang cukup besar, sistem pakar yang dibuat berusaha untuk membantu pemilik hewan untuk mendiagnosa penyakit yang dialami kucing jenis persia yaitu Rabies, Gagal Ginjal, Panleukopenia, Feline Infection Peritonitis, dan Feline Calici Virus. Penelitian ini menggunakan pendekatan Forward chaining untuk memvalidasi data penyakit dan gejala pada penelitian ini dilakukan dengan wawancara langsung dengan dokter hewan yang bekerja di klinik sahabat hewan. Pengujian dilakukan dengan menggunakan metode blackbox. Adapun hasil yang diharapkan dari penelitian ini adalah bagaimana pendekatan forward chaining dapat diterapkan untuk membantu mendiagnosa penyakit pada kucing jenis persia.

Topic: Rabies epidemiology and control
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
MECHANISMS OF POPULATION DIFFERENTIATION IN MARBLED MURRELETS: HISTORICAL VERSUS CONTEMPORARY PROCESSES

Abstract Mechanisms of population differentiation in highly vagile species such as seabirds are poorly understood. Previous studies of marbled murrelets (Brachyramphus marmoratus; Charadriiformes: Alcidae) found significant population genetic structure, but could not determine whether this structure is due to historical vicariance (e.g., due to Pleistocene glaciers), isolation by distance, drift or selection in peripheral populations, or nesting habitat selection. To discriminate among these possibilities, we analyzed sequence variation in nine nuclear introns from 120 marbled murrelets sampled from British Columbia to the western Aleutian Islands. Mismatch distributions indicated that murrelets underwent at least one population expansion during the Pleistocene and probably are not in genetic equilibrium. Maximum-likelihood analysis of allele frequencies suggested that murrelets from “mainland” sites (from the Alaskan Peninsula east) are genetically different from those in the Aleutians and that these two lineages diverged prior to the last glaciation. Analyses of molecular variance, as well as estimates of gene flow derived using coalescent theory, indicate that population genetic structure is best explained by peripheral isolation of murrelets in the Aleutian Islands, rather than by selection associated with different nesting habitats. No isolation-by-distance effects could be detected. Our results are consistent with a rapid expansion of murrelets from a single refugium during the early–mid Pleistocene, subsequent isolation and divergence in two or more refugia during the final Pleistocene glacial advance, and secondary contact following retreat of the ice sheets. Population genetic structure now appears to be maintained by distance effects combined with small populations and a highly fragmented habitat in the Aleutian Islands. Corresponding Editor: J. Neigel

Topic: Genetic diversity and population structure
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
[Gestational pyelonephritis: modern aspects of diagnosis and treatment].

Acute gestational pyelonephritis (AGP) is considered to be a complicated urinary tract infection with altered urodynamics on the affected side. We analyzed minimally invasive treatment results achieved in 57 females with AGP. Pyelonephritis has been diagnosed basing on the results of physical examination, urinalysis and urine culturing. Conventional, Doppler ultrasound and MR tomography provided early diagnosis and AGP staging. A timely upper urinary tract drainage with an ureteral stent and adequate antibacterial and antiinflammatory treatment made it possible to avoid open surgical treatment and effectively treat 56 of 57 patients (98.2%). Out of 55 patients with 39-40 week pregnancy, 43 women had normal vaginal delivery and 12 delivered by the cesarian section. In two cases delivery by cesarian section at weeks 36-37 was performed because of individual intolerance of an ureteral stent. All the neonates were born healthy (7-9 points by Apgar score). Recently gained experience in early diagnosis and treatment of AGP and good follow-up results demonstrate a clear benefit from the use of minimally invasive diagnostic and treatment methods.

Topic: Pediatric Urology and Nephrology Studies
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
Out-of-plane rocking response of unreinforced masonry churches after the 2011 Canterbury (New Zealand) and 2016 Central Italy earthquakes

Churches are an essential part of the historical and architectural heritage of a country and various earthquakes around the world have highlighted the significant seismic vulnerability of ancient religious buildings. Recently, the 2010-2011 Canterbury (New Zealand) earthquake sequence caused extreme damage, being particularly extensive in Christchurch unreinforced masonry churches. Similarly, the 2016 Central Italy earthquake strongly affected the religious buildings of the stricken area, where churches showed systematic collapses, causing uncountable losses to the Italian ecclesiastic heritage. Historical unreinforced masonry buildings are known to suffer from local collapses during strong earthquakes, and this observation is even more evident for churches, because of their open plan, large wall height-to-thickness and length-to-thickness ratios, and the presence of thrusting horizontal structural elements for vaults and roofs. A sample of approximately 80 affected buildings was directly surveyed after each seismic sequence, with the aim of identifying the activated collapse mechanisms, highlighted by cracks and deformations. Although geographically on opposite sides of the world, several churches in the two stricken regions exhibited out-of-plane response of their façades, and the corresponding mechanism is herein analysed for a church for each country using rigid-body non-linear dynamic models. The models, which account for the real geometry of the structural element, are excited by recorded accelerograms. The outcomes of such analyses are in good agreement with observed damages.

Topic: Masonry and Concrete Structural Analysis
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
Stochastic Modeling of Sediment Connectivity for Reconstructing Sand Fluxes and Origins in the Unmonitored Se Kong, Se San, and Sre Pok Tributaries of the Mekong River

Abstract Sediment supply to rivers, subsequent fluvial transport, and the resulting sediment connectivity on network scales are often sparsely monitored and subject to major uncertainty. We propose to approach that uncertainty by adopting a stochastic method for modeling network sediment connectivity, which we present for the Se Kong, Se San, and Sre Pok (3S) tributaries of the Mekong. We quantify how unknown properties of sand sources translate into uncertainty regarding network connectivity by running the CASCADE (CAtchment Sediment Connectivity And DElivery) modeling framework in a Monte Carlo approach for 7,500 random realizations. Only a small ensemble of realizations reproduces downstream observations of sand transport. This ensemble presents an inverse stochastic approximation of the magnitude and variability of transport capacity, sediment flux, and grain size distribution of the sediment transported in the network (i.e., upscaling point observations to the entire network). The approximated magnitude of sand delivered from each tributary to the Mekong is controlled by reaches of low transport capacity (“bottlenecks”). These bottlenecks limit the ability to predict transport in the upper parts of the catchment through inverse stochastic approximation, a limitation that could be addressed by targeted monitoring upstream of identified bottlenecks. Nonetheless, bottlenecks also allow a clear partitioning of natural sand deliveries from the 3S to the Mekong, with the Se Kong delivering less (1.9 Mt/yr) and coarser (median grain size: 0.4 mm) sand than the Se San (5.3 Mt/yr, 0.22 mm) and Sre Pok (11 Mt/yr, 0.19 mm).

Topic: Soil erosion and sediment transport
Subfield: Soil Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Introduction

Abstract This introductory chapter sets out the book's purpose, which is to explore the rich legal tradition of the Eastern Mediterranean. It assesses the tension between law and religion as two cultural (sub)systems within society that compete for absolute power. It addresses the question of how these two systems exist next to each other in either harmony or conflict, and what strategies are employed in ancient societies to fuse both concepts in a meaningful unity that would govern society. An overview of the subsequent chapters is also presented.

Topic: Classical Antiquity Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Evaluation of Antioxidant Activity and Treatment of Eczema by Berberine Hydrochloride-Loaded Liposomes-in-Gel

In this paper, berberine hydrochloride-loaded liposomes-in-gel were designed and developed to investigate their antioxidant properties and therapeutic effects on the eczema model of the mouse. Berberine hydrochloride-liposomes (BBH-L) as the nanoparticles were prepared by the thin-film hydration method and then dispersed BBH-L evenly in the gel matrix to prepare the berberine hydrochloride liposomes-gel (BBH-L-Gel) by the natural swelling method. Their antioxidant capacity was investigated by the free radical scavenging ability on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and H2O2 and the inhibition of lipid peroxides malondialdehyde (MDA). An eczema model was established, and the efficacy of the eczema treatment was preliminarily evaluated using ear swelling, the spleen index, and pathological sections as indicators. The results indicate that the entrapment efficiency of BBH-L prepared by the thin-film hydration method was 78.56% ± 0.7%, with a particle size of 155.4 ± 9.3 nm. For BBH-L-Gel, the viscosity and pH were 18.16 ± 6.34 m Pas and 7.32 ± 0.08, respectively. The cumulative release in the unit area of the in vitro transdermal study was 85.01 ± 4.53 μg/cm2. BBH-L-Gel had a good scavenging capacity on DPPH and H2O2, and it could effectively inhibit the production of hepatic lipid peroxides MDA in the concentration range of 0.4–2.0 mg/mL. The topical application of BBH-L-Gel could effectively alleviate eczema symptoms and reduce oxidative stress injury in mice. This study demonstrates that BBH-L-Gel has good skin permeability, excellent sustained release, and antioxidant capabilities. They can effectively alleviate the itching, inflammation, and allergic symptoms caused by eczema, providing a new strategy for clinical applications in eczema treatment.

Topic: Advancements in Transdermal Drug Delivery
Subfield: Pharmaceutical Science
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences
Metabolism, anticholinergic effects, and therapeutic outcome of desmethylimipramine in depressive illness

Synopsis In order to test two theories of the mode of action of imipramine 58 depressive patients were treated at two dosage levels with desmethylimipramine (DMI), its active metabolite. Clinical judgments were used to distinguish therapeutic responders from non-responders, who showed clear differences in depressive rating scales and body weight changes. Measurements of urinary output of DMI, of salivation, and of the incidence of side-effects were compared in responders and non-responders: no differences appeared between the two groups. It is concluded that the therapeutic effect of imipramine does not depend on either its anticholinergic or other action revealed by the common side-effects, and that variability of response cannot be accounted for by differences in the rate of metabolism of DMI.

Topic: Treatment of Major Depression
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
AirSense Autoset For Her and Him

Mehrere Studien konnten aufzeigen, dass es geschlechtstypische Unterschiede in den Symptomen der obstruktiven Schlafapnoe (OSA) gibt. Mit dem "AirSense 10 Autoset for Her" (ResMed HealthCare GmbH, Martinsried) wurde ein Algorithmus verfügbar, der OSA bei Frauen besser therapieren soll, als der bisherige Autoset-Algorithmus. Die vorliegende Studie untersucht die Effektivität des "for Her" Modus (AfH) im Vergleich zum etablierten Modus (ASstd) in der OSA-Therapie bei Frauen und Männern.

Topic: Pediatric health and respiratory diseases
Subfield: Emergency Medical Services
Field: Health Professions
Domain: Health Sciences
An Automated Therapy Chair for Patients having Chronic Obstructive Pulmonary Disease (COPD)

Many people over 40 years of age suffer from Chronic Obstructive Pulmonary Disease (COPD). It encompasses several lung diseases including chronic bronchitis, emphysema, and asthma. Since COPD is not a curable disease rather it is a progressive disease, so its treatment is basically to retard the progression. Exercise is treated as one of the effective means of keeping the patient relatively better and doctors often suggest to apply a number of puffs manually on the patient's back at a certain speed. Manual system is prone to error because by mistake it may end up with the application of overdose deteriorating the condition of the patient. This paper describes the development of an automatic puffing system. The development is centered around an automatic puffing chair. The automated puffing speed and the number can be adjusted and different respiratory medicines are kept on a tray which is a part of the chair. The chair is used in Dhaka medical college hospital where it is applied to some patients and it demonstrated an amazing improvement in their situation.

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Impact of Sustainable Environmental Expenditures Policy on Air Pollution Reduction, During European Integration Framework

Pursuant to the growth of society, against the boosting of scientific and technological progress, also arises the negative effect of pollution acceleration. In this context, we relate to risks that imply the growth of pollution, especially against nuisance air pollution increase (CO, SO2, NO etc.) with major implications on the growth of greenhouse effect, the melting of the ice fields, respectively the pollution of the soil with nitrates from fertilizers intensively used in agriculture. Our study is up-to-date, as pursuant to the ONU Conference from Paris (France 2015, Conference on Climate Changes), they reached an agreement and the adopted text admits the menace of climate modifications is far more important than previously acknowledged and engages the participants to reduce their pollutant emissions. The researchers' current concerns focus on studying the effects of the redistribution of financial resources obtained by practising the ‘green' fiscal policy on dependent variables. Observing them, we integrate the respective variables into complex models analysed by multiple regression (both standard and robust) and the fixed effects panel on 20 European countries which also reflect the different effects on the environmental policy and the expenses it incurred. The main purpose of the analysis we aim to accomplish is the impact of the policy for environment expenditure tenable within the European framework on against nuisance air pollution attenuation. The statistical analysis aims at identifying these effects by means of regression equations (OLS), robust regression (M method), fixed and random effects, using panel data from 18 EU countries, as well as Switzerland and Turkey due to their position in relation to the community block; we will analyse the period between 1995-2013. Further to the application of multiple regression statistical methods (OLS and robust M), our results show that teimiqgdp expenses played a major role in the reduction of carbon monoxide. These are the total investments made in the mining sector; when these expenses were raised by 1% of the GDP value, there was a decrease of 11 628.3 thousand tons Cot at the level of the European countries analysed, according to the result of the OLS analysis, based on the robust M estimation.

Topic: Energy, Environment, Economic Growth
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Hydrothermal Circulation and Geochemical Flux at Mid-Ocean Ridges

The flow rate of sea water through sub-sea-floor hydrothermal systems at mid-ocean ridges has been estimated at $$1.3-9 \times 10^{17} g/yr$$ by consideration of the rate at which circulating fluid must advect heat out of the spreading plates into the oceans. The rate of hydrothermal heat advection was obtained by computing the difference ($$40 \pm 4 \times 10^{18} cal/yr$$) between the theoretical heat production associated with sea-floor spreading and observed heat flow measurements. Effects of exothermic chemical reactions, direct heat loss from flows extruded on the ocean floor, and heat of crystallization of basalt were minor and yielded insignificant contributions to the estimate. The majority of dredged ocean-floor metamorphic rocks appear to represent the products of intensive hydrothermal reaction with hot sea water. The chemical trends (loss of Ca and K, gain of Mg, Na, and $$H_{2}O$$) and alteration mineral assemblages of these rocks closely resemble those observed in both laboratory alteration experiments and in subaerial geothermal systems where sea water circulates in hot basic rocks. Alteration of oceanic crust appears strongly dependent on the presence of permeable features, especially cracks, and may be restricted mainly within the vicinity of major fault zones. An examination of submarine weathering, volcanic effusion, and hydrothermal mass transfers between basaltic crust and sea water for silica, manganese, and iron demonstrated that the relative importance of the three processes may vary markedly from element to element. A similar examination of magnesium, calcium, oxidants-reductants, and water indicated that only about a kilometer or less of basalt actually reacts with sea water in hydrothermal systems.

Topic: Hydrocarbon exploration and reservoir analysis
Subfield: Mechanics of Materials
Field: Engineering
Domain: Physical Sciences