jimnoneill/paper-to-field-training huggingface dataset:
Effect of Mesenchymal Stem Cells and Chicken Embryo Extract on Flap Viability and Mast Cells in Rat Skin Flaps

<i>Study Objective</i>: We investigated the effect of bone marrow mesenchymal stem cells (BMMSCs) and chicken embryo extract (CEE), alone and in combination, on tissue viability of skin flaps, and mast cells (MCs), in an experimental random skin flap (RSF) rat model. <i>Materials and Methods</i>: A 30 mm × 80 mm RSF was made on the dorsum of each of the forty rats, which were then divided into four groups. One group did not receive any treatment and served as the control, the second group received BMMSCs, the third group received CEE + BMMSCs, and the fourth group received CEE. For BMMSC treatment, 6 × 10<sup>9</sup> BMMSCs were injected into twelve separate injection sites of each flap. Seven days after RSF surgery, the remaining viable part of each flap was measured and examined to determine the number of blood vessels, MCs, and degranulated MCs. <i>Results</i>: The CEE, CEE + BMMSC, and BMMSC groups displayed significantly higher levels of flap viability (ANOVA test: <i>p</i> = 0.000; LSD test for all groups: <i>p</i> = 0.000), and a greater number of vessels (ANOVA test: <i>p</i> = 0.000; LSD test: <i>p</i> = 0.000, 0.002, and 0.012, respectively), compared with the control group. The flap viability was poorer in the BMMSC group than in the CEE and CEE + BMMSC groups. The BMMSC group also had a greater number of degranulated and total MCs, compared with the CEE and CEE + BMMSC groups. <i>Conclusions</i>: We observed biostimulatory effects of BMMSCs, CEE, and CEE + BMMSCs on flap viability and vessel numbers, compared to the control group. MCs produced in response to BMMSC treatment have an inhibitory effect on the RSFs survival in an ischemic tissue model.

Topic: Mesenchymal stem cell research
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Clinicopathological Findings of Surgically Treated Nasal Cavity Schwannomas: A Case Series

Objectives: Nasal cavity schwannomas are exceedingly rare, benign neoplasms that pose challenges in clinical differentiation from other nasal tumors. Methods: This study presents 5 cases of nasal cavity schwannoma treated surgically over a 10 year period, along with a review of the literature. Results: The most prevalent symptoms included unilateral nasal obstruction and intermittent nosebleeds. Tumors originated from various nasal sites, including the septum, middle conchae, lateral nasal wall, and alar mucosa. All surgeries were conducted transnasally, with 3 tumors excised en bloc, and the remaining two subjected to piecemeal resection. Ancient schwannoma was identified in 4 cases. No instances of recurrence were observed during the average 61 month follow-up period. Conclusions: The definitive diagnosis of schwannomas necessitates histopathological examination. An endoscopic approach to the nasal cavity, obviating the need for external intervention, proved highly effective and appropriate for both diagnosis and symptom alleviation.

Topic: Neurofibromatosis and Schwannoma Cases
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Fitting a Filtered Poisson Process

A technique has been developed for generating an approximate characterization of a class of non-Gaussian stochastic processes. The class of processes considered are basically those non-Gaussian stationary processes for which the fourth moments of the univariate distributions are greater than the fourth moments of corresponding Gaussian approximations to the processes. In addition, the processes are assumed to be one-dimensional with continuous sample functions and the corresponding autocovariance functions are assumed to go to zero within finite time intervals. The characterization is accomplished by fitting a filtered Poisson process to the non-Gaussian process by matching the autocovariance function and an arbitrary number of the lower order univariate moments of the two processes. In matching the autocovariance function, a problem mathematically equivalent to the “factorization” of the power spectrum of a stationary process is solved numerically using an iterative procedure. The main advantage of using the filtered Poisson process is that linear operations on these processes yield filtered Poisson processes. This then simplifies the determination of probabilistic information of the output of a stochastic process passed through linear filters. Such considerations might be required, for example, in reliability problems involving random vibrations of linear mechanical systems.

Topic: Probabilistic and Robust Engineering Design
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
YPC‐21661 and YPC‐22026, novel small molecules, inhibit ZNF143 activity <i>in vitro</i> and <i>in vivo</i>

Zinc‐finger protein 143 (ZNF143) is a transcription factor that is involved in anticancer drug resistance and cancer cell survival. In the present study, we identified a novel small molecule N ‐(5‐bromo‐2‐methoxyphenyl)‐3‐(pyridine‐3‐yl) propiolamide (YPC‐21661) that inhibited ZNF143 promoter activity and down‐regulated the expression of the ZNF143‐regulated genes, RAD51, PLK1, and Survivin, by inhibiting the binding of ZNF143 to DNA. In addition, YPC‐21661 was cytotoxic and induced apoptosis in the human colon cancer cell line, HCT116 and human prostate cancer cell line, PC‐3. 2‐(pyridine‐3‐ylethynyl)‐5‐(2‐(trifluoromethoxy)phenyl)‐1,3,4‐oxadiazole (YPC‐22026), a metabolically stable derivative of YPC‐21661, induced tumor regression accompanied by the suppression of ZNF143‐regulated genes in a mouse xenograft model. The present study revealed that the inhibition of ZNF143 activity by small molecules induced tumor regression in vitro and in vivo ; therefore, ZNF143 is a promising target of cancer therapeutics.

Topic: Cancer-related Molecular Pathways
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Ecophysiological responses of <i>Araucaria angustifolia</i> seedlings to different irradiance levels.

Brazilian pine ( Araucaria angustifolia [Bert.] O.Ktze.) is an indigenous conifer of the southern region of South America, typically regarded as a sun-loving species. However, there is insufficient information on the species’ behaviour under different irradiances to characterise its plasticity to light. The purpose of this work was to measure some ecophysiological responses of Brazilian pine seedlings to three irradiance levels: 100, 45 and 10% full sunlight. Thirty seedlings were grown under each of the irradiance treatments and, after 5 months, growth parameters, leaf chlorophyll concentration and in vivo nitrate reductase activity, in both leaves and roots, were analysed. There was no increase in shoot biomass allocation in response to shading, in contrast to results from other experiments. Only low-light seedlings showed significant increase in specific leaf area, as well as in the ratio of height to shoot biomass. Chlorophyll content and the ratio of chlorophyll a to chlorophyll b did not vary among treatments. Nitrate reductase activity was detected only in roots and was reduced in the low-light treatment. An overall analysis of the results points to a normal growth of Brazilian pine seedlings at both high- and medium-light sites, at least in their initial stages of development.

Topic: Growth and nutrition in plants
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Solvent Driving Force Ensures Fast Formation of a Persistent and Well-Separated Radical Pair in Plant Cryptochrome

The photoreceptor protein cryptochrome is thought to host, upon light absorption, a radical pair that is sensitive to very weak magnetic fields, endowing migratory birds with a magnetic compass sense. The molecular mechanism that leads to formation of a stabilized, magnetic field sensitive radical pair has despite various theoretical and experimental efforts not been unambiguously identified yet. We challenge this unambiguity through a unique quantum mechanical molecular dynamics approach where we perform electron transfer dynamics simulations taking into account the motion of the protein upon the electron transfer. This approach allows us to follow the time evolution of the electron transfer in an unbiased fashion and to reveal the molecular driving force that ensures fast electron transfer in cryptochrome guaranteeing formation of a persistent radical pair suitable for magnetoreception. We argue that this unraveled molecular mechanism is a general principle inherent to all proteins of the cryptochrome/photolyase family and that cryptochromes are, therefore, tailored to potentially function as efficient chemical magnetoreceptors.

Topic: Plant Molecular Biology Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
The Limits of White House Image Control

Journal Article The Limits of White House Image Control Get access Mark J. Rozell Mark J. Rozell MARK J. ROZELL is associate professor of political science at Mary Washington College. He is the author of The Press and the Ford Presidency and The Press and the Carter Presidency. Search for other works by this author on: Oxford Academic Google Scholar Political Science Quarterly, Volume 108, Issue 3, Fall 1993, Pages 453–480, https://doi.org/10.2307/2151699 Published: 15 September 1993

Topic: Rhetoric and Communication Studies
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
A Study on the Development of the Shirts for Business Attire based on Korean Heritage in Relation to Saving Energy in the Summer

비문해자의 불평등하고 불편한 삶을 고려할 때 문해교육의 확대는 한국평생교육의 시급한 과제이다. 문해교육의 확대를 위해서는 문해교육을 통한 비문해자의 삶의 변화에 대한 다양한 연구 축적이 도움이 된다. 다양한 연구에는 비문해자의 삶을 분석하기 위한 다양한 소재를 활용하는 것도 포함된다. 본 연구는 전국 성인문해교육 시화전 우수작품집에 실린 시를 분석하여 비문해의 시작과 지속, 비문해의 어려움, 문해교육의 의의, 비문해자의 변화를 탐색하는 것을 목적으로 하였다. 이를 위해 전국 성인문해교육 시화전 우수작품집에 실린 647편의 시를 대상으로 내용분석하였다. 분석 결과를 보면, 첫째, 비문해의 시작과 지속은 사회구조적 문제와 연결되었으며, 비문해자는 학습을 하려고 노력하는 모습을 보였다. 비문해시기는 춥고 어두운 터널과 같았다. 둘째, 문해교육을 통해 글을 읽고 쓸 수 있게 되면서 공부의 기쁨을 느끼고 비문해자의 삶에 새로운 변화가 나타났다. 시에서 나타나는 메타포는 ‘까마귀’, ‘동창생’, ‘콩나물’ 등이 있었다. 셋째, 비문해자에게 삶은 봄날이나 꽃과 같이 밝고, 따뜻하고, 화사하게 변하였으며, 계속해서 학습하려는 꿈을 꾸고, 새로운 역할에 도전하는 모습이 나타났다. 메타포는 ‘봄날’, ‘글자꽃’, ‘꿈보따리’, ‘어깨펴고’, ‘싸인’ 등이 있었다. 이러한 분석 결과를 토대로 문해교육에 대한 논의와 시사점을 제시하였다.

Topic: Consumer Perception and Purchasing Behavior
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
God, Gods, Humans, and <i>Sinnekens</i> in Classical Rhetoricians Plays

This collection of essays by international scholars focuses on the vernacular urban culture of the Chambers of Rhetoric in the Low Countries of the fifteenth and sixteenth centuries. Reflecting social, religious, and economic realities at a time of fundamental change, the Rhetoricians’ plays also reveal a range of poetic and theatrical conventions that make them an important source of information both on practical stagecraft and on the role of theatre in the urban community, as seen in their involvement in civic processions or the organization of drama competitions. The volume sets the Rhetoricians’ drama in the cultural life of the provinces of the Low Countries during a period dominated by ruling foreign dynasties: the Burgundian dukes and then the Habsburg dynasty, most prominently the Emperor Charles V and his son King Philip II of Spain. It was a time of intense religious controversy which gave rise to debates both on and off stage. These debates, far from damaging Rhetorician culture, actually stimulated its activities and development to such an extent that Rhetoricians became representative voices for their time. The admixture of entertainment and education offered by the Chambers to their own members - and to a wider public - was one which, though originating in a medieval context, soon became linked with humanist and Renaissance thinking. This volume illustrates how, as a consequence, the Chambers of Rhetoric contributed to the development in the Low Countries of an increasingly articulate society.

Topic: Rhetoric and Communication Studies
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
Metoclopramide in vincristine-induced ileus.

Three cases of vincristine-induced gastrointestinal toxicity were treated with metoclopramide. Two patients had severe abdominal pain and adynamic ileus, while the third had severe constipation and abdominal bloating. Rapid resolution of symptoms occurred in all three patients. Metoclopramide may, therefore, prove useful in the treatment of these not infrequent toxic effects of vinca alkaloids.

Topic: Nausea and vomiting management
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Clinical profile of patients with tinea versicolor

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;Pityriasis versicolor is a superficial fungal infection caused by the polymorphous endogenous yeast &lt;em&gt;Malassezia furfur&lt;/em&gt;. Infection typically occurs on the trunk and proximal upper extremities and is characterized by distinctive scaly, coalescent hyperpigmented and/or hypopigmented to erythematous patches. Tinea versicolor is a superficial chronically recurring fungal infection of the stratum corneum, characterized by scaly, hypo and hyperpigmented irregular macules, usually located on the trunk and proximal extremities caused by pityrosporum orbiculare.&lt;/span&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;100 patients of untreated tinea versicolor who attended the outpatient department were selected at random irrespective of their age, socioeconomic status, occupation. A detailed history was taken, regarding the age, sex, religion, occupation, socioeconomic status, residence, duration and course of the disease, site of distribution of lesion and any other associated cutaneous and systemic diseases&lt;/span&gt;.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;The majority patients i.e. 27 (27%) were students and followed by the unskilled workers who comprised 20% of patients. The incidence is quite low in business and official class 3% and 11% respectively. &lt;/span&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;span lang="EN-IN"&gt;The duration of the disease in 93% of patients was less than 10 years and in 7% the duration was more than 10 years.&lt;/span&gt;&lt;/p&gt;

Topic: Nail Diseases and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Supplementary Table 1 from Immune Consequences of Decreasing Tumor Vasculature with Antiangiogenic Tyrosine Kinase Inhibitors in Combination with Therapeutic Vaccines

&lt;p&gt;Effect of sunitinib alone, rMVA-Twist-TRICOM vaccine alone, or sunitinib in combination with vaccine on the phenotype of tumor-infiltrating MDSCs and TAMs in the 4T1 breast tumor model.&lt;/p&gt;

Topic: Angiogenesis and VEGF in Cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Synthesis of Heptakis (2‐O‐methyl)‐β‐cyclodextrin

Abstract The title compound was prepared by a reaction sequence comprising methylation of heptakis (6‐bromo‐6‐deoxy)‐β‐cyclodextrin by the Kuhn procedure, regeneration of the primary hydroxyl groups from the resulting heptakis(2‐O‐methyl‐6‐bromo‐6‐deoxy)‐β‐dextrin via the 6‐O‐benzoate ester by benzoate exchange and subsequent deesterification. It was proved that the methyl groups in the tetradeca‐O‐methyl ether of β‐dextrin are located 0–2 and 0–6 of the D‐glucose residues.

Topic: Diabetes Treatment and Management
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Increased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin–Angiotensin System in Goldblatt Hypertension

Abstract BACKGROUND Renovascular hypertension (2-kidney 1-clip model (2K1C)) is characterized by renin–angiotensin system (RAS) activation. Increased Angiotensin II (AngII) leads to sympathoexcitation, oxidative stress, and alterations in sodium and water balance. AIM The aim of this study was to evaluate whether a discrete increase in sodium chloride intake in 2K1C rats leads to changes in cardiovascular and autonomic function, oxidative stress, and renin angiotensin aldosterone system. METHODS After 4 weeks of induction of hypertension, rats were fed a normal sodium diet (0.4% NaCl) or a high-sodium diet (2% NaCl) for 2 consecutive weeks. Experiments were carried out for 6 weeks after clipping. Mean arterial pressure (MAP), renal sympathetic nerve activity (rSNA), arterial baroreflex control of rSNA, and heart rate (HR) were assessed. Thiobarbituric acid reactive substances and glutathione were measured as indicators of systemic oxidative stress. Angiostensin-converting enzyme (ACE), ACE2, and angiotensinogen were evaluated in clipped and unclipped kidneys as also urinary angiotensinogen and plasma renin activity. Angiotensinogen, plasma renin activity (PRA) and angiotensin-converting enzyme (ACE) and ACE2 in clipped and unclipped kidneys were evaluated. RESULTS High-sodium diet did not change systemic oxidative stress, and basal values of MAP, HR, or rSNA; however, increased renal (−0.7±0.2 vs. −1.5±0.1 spikes/s/mm Hg) and cardiac (−0.9±0.14 vs. −1.5±0.14 bpm/mm Hg) baroreceptor reflex sensitivity in 2K1C rats. Although there was no alteration in PRA, a high-salt diet significantly decreased urinary angiotensinogen, ACE, and ACE2 expressions in the clipped and unclipped kidneys. CONCLUSIONS Increased arterial baroreceptor control associated with a suppression of the intrarenal RAS in the 2K1C rats on high-salt diet provide a salt-resistant effect on hypertension and sympathoexcitation in renovascular hypertensive rats.

Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Specific interaction of fatty acyl-CoA esters with brown adipose tissue mitochondria

The ability of low concentrations of long-chain fatty acyl coenzyme A (CoA) esters to act as inhibitors of purine nucleotide action in hamster brown adipose tissue mitochondria was observed to result from a specific interaction. Palmitoyl-CoA was found to be a competitive inhibitor of nucleotide binding with an apparent Ki of 2.46 +/- 1.09 microM for GDP and 2.98 +/- 0.538 microM for ATP and was able to counteract GDP-inhibited mitochondrial swelling. A minimum acyl-CoA carbon chain length of 12 was necessary for any significant inhibition of GDP binding or induction of swelling to be observed. The effect of palmitoyl-CoA on reversing GDP-inhibited chloride permeability of brown adipose tissue mitochondria was found to be the result of a specific interaction with the brown adipose tissue mitochondrial uncoupling protein. Mitochondria pretreated with N,N'-dicyclohexylcarbodiimide, which binds covalently to the uncoupling protein and partially inhibits brown adipose tissue mitochondrial swelling, underwent a nonspecific increase in swelling in the presence of phenylmercuric acetate. However, with palmitoyl-CoA no further increase in permeability could be mediated. In addition, under certain experimental conditions, palmitoyl-CoA was found to partially inhibit the high halide permeability of brown adipose tissue mitochondria but to a lesser extent than that observed with GDP, suggesting it may be acting as a partial agonist.

Topic: Adipose Tissue and Metabolism
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Encoding controlled vocabularies for the Semantic Web using SKOS Core

Purpose The purpose of this paper is to introduce digital librarians to a new encoding standard for developing semantically‐rich controlled vocabularies which will enhance searching of digital content. Design/methodology/approach Literature‐based review. Findings SKOS Core serves as an efficient and practical segue from traditional knowledge organization systems such as thesauri and classification systems to more complex and logic‐driven Semantic Web languages. Practical implications Librarians with a need to provide semantically‐rich access to digital resources will find SKOS Core a useful addition to their metadata tool kits. Originality/value Provides a useful and practical introduction to a new Semantic Web tool which should be of great interest to librarians tasked with integrating knowledge organization systems into digital libraries.

Topic: Semantic Web and Ontologies
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
Lymphocyte stimulation response in horses against phytohaemagglutinin and M protein of Streptococcus equi using whole blood.

Lymphocyte stimulation was observed in whole equine blood in the presence of phytohaemagglutinin and M protein extracted from a typical strain of Streptococcus equi. Blood samples were collected from several healthy horses and horse and pony foals and cultured in vitro with varying concentrations of phytohaemagglutinin and M protein for several days. Phytohaemagglutinin was found to induce lymphocyte stimulation in these animals. Highest mean stimulation indices in horse foals (49.3 +/- 24.4) and pony foals (54.7 +/- 32.0) were observed with 0.625 and 1.25 micrograms/mL phytohaemagglutinin, respectively, at either 72 or 96 hours of incubation. Significantly higher radioactive counts per minute in horse and pony foals were recorded in blood cultures incubated with 0.625 and 1.25 micrograms/mL phytohaemagglutinin. M protein induced a dose related stimulation response in adult horses. Maximum stimulation indices were observed against 125 micrograms/mL M protein at 96 hours. These stimulation indices were higher in adult horses (40.0 +/- 2.2) than observed in pony foals (14.4 +/- 15.7). Higher stimulation levels in adult horses indicated either nonspecific stimulation against M protein or previous exposure of these animals to S. equi.

Topic: Toxin Mechanisms and Immunotoxins
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Incidence pattern of pink bollworm, Pectinophora gossypiella (Saund.)on different event Bt and non-Bt cottons

A field experiment was conducted at the Agricultural Research Station, Dharwad Farm, Dharwad, Karnatakaduring 2018-19 to evaluate the performance of cultivated cotton genotypes including Bt and non-Bt against pink bollworm,Pectinophora gossypiella (Saund.) under rainfed conditions. Based on seasonal mean green boll damage, Everest (13.56%)performed better against pink bollworm over single gene BG-I Bt variety PAU Bt-1 (16.55%), BG-I Bt hybrid MRC 6918(25.88%) (Both expressing Cry1Ac) and Arjun-21 Cry1A) and BG-II hybrid MRC 7918 (15.52%).DCH-32 (Non Btinterspecific hybrid) had maximum infestation of 37.59 per cent followed by H×H hybrid DHH-263 (36.34%), Suvin(21.38%), DDhc-11 (21.59%), Sahana (20.21%) and DLSa-17 (18.65%). The maximum larval recovery was 12.66 per 20green bolls in DCH-32 followed by DHH-263 (12.58) and Suvin (11.12). In general, Non-Bt genotypes had higher incidencethan Bt genotypes. Similarly, among Bt toxin, Cry1Ac and Cry2Ab expressing genotype had lower incidence.

Topic: Insect Resistance and Genetics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences