jimnoneill/paper-to-field-training huggingface dataset:
A study on the effect of vitamin d supplementation on primary dysmenorrhea: A prospective case control study

Dysmenorrhea is a common problem among women of reproductive age group. The aim of this study is to investigate the effect of vitamin D supplementation in treatment of primary dysmenorrhea. A study was conducted on 60 women with primary dysmenorrhea and vit D deficiency referred to our OPD. Eligible women were randomly selected into treatment and control groups (30 in each group). Individuals in the treatment group received 50 000 IU oral vit D and the control group received placebo weekly for eight weeks. After two months of treatment, there was a significant difference in serum vit D concentration between the two groups (p< 0.001). Pain severity decreased in treatment group after eight weeks of treatment. There was a significant difference in pain intensity between the two groups after eight weeks of treatment. A weekly dose of (50 000 IU) oral vit D supplementation for eight weeks in patients with primary dysmenorrhea could improve pain intensity.

Topic: Menstrual Health and Disorders
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Colonic metastasis from primary lung adenocarcinoma

Primary lung cancer is a leading cause of cancer-related deaths in Korea. Approximately 50% of patients have metastatic disease at the time of presentation. The preferential sites of extrapulmonary spread include lymph nodes, liver, brain, adrenal glands, and bones. Gastrointestinal metastasis from primary lung cancer is extremely rare and only a few case reports have been published. Herein, we report a case of metastatic colon cancer from primary lung adenocarcinoma, presenting multiple cecal polypoid masses.

Topic: Metastasis and carcinoma case studies
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
ANALISIS TINGKAT KEUNTUNGAN USAHA PENGGEMUKAN SAPI POTONG RAKYAT DI KABUPATEN WONOGIRI

Beef cattle breeding business in Wonogiri District is dominated by small scale in which capital and profits too low. The size of the profits derived from the balance of the sale value of production and production costs that is issued by the breeder. The maximum profit would be achieved if all factors of production have been allocated in an optimal and efficient use, both technically and economically efficient manner. Objective analysis profit function is to describe the situation now, the circumstances in the future or planning and action of a business related to the rate of business profit and net income scale beef cattle farms of the people.The results showed that total revenue (TR) of beef cattle breeding business people have an average of Rp.89.360.625.00 per farmer per one period of fattening cattle, while the total cost (TC) on average Rp.85.119.873.00 each farmers per one period of fattening cattle. So that the magnitude of the rate of profit(π) obtained by each farmer in one period of fattening cattle for Rp.4.240.752.00 and the R / C ratio of 1:05. The results of the analysis showed that the profit rate of beef cattle breeding business in Wonogiri Regency financially advantageous (value profit π&gt; 0 and the return value cost ratio of R / C&gt; 1). Results of regression equation analysis function simultaneously benefit breeders show concentrate feed costs, labor costs and costs of cows significant ((P &lt;0.05)) on the level of business profit beef cattle farms in Wonogiri. Based on the calculation of the value of R2 adjusted Rvalues obtained2 83.2% showed variable variation concentrate feed and forage costs, drug costs, labor costs, fees and charges cage feeder cattle can be explained by either a variable rate of the business profits of beef cattle breeders. The remaining 16.8% operating income level variable cattle ranchers explained by variations in other variables outside the model. Partially variable concentrate feed costs, labor costs and the cost of feeder cattle significantly (P &lt;0.05) to the level of business profit breeding beef cattle people. As for the cost of forage ariable drug costs are not significant (P&gt; 0.5) on the level of beef cattle breeding business benefit of the people. Keywords: Function Gain, Beef Cattle, Wonogiri

Topic: Livestock Farming and Management
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Staphylococcus aureus Tet38 Efflux Pump Structural Modeling and Roles of Essential Residues in Drug Efflux and Host Cell Internalization

The Staphylococcus aureus Tet38 membrane protein has distinct functions, including drug efflux and host cell attachment and internalization mediated by interaction with host cell CD36. Using structural modeling and site-directed mutagenesis, we identified key amino acids involved in different functions.

Topic: Antimicrobial Resistance in Staphylococcus
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
When To take what: QoE-aware resource redistribution among web browsing users and the potential of prioritizing QoE sensitive content

In this paper we propose evaluation models and calculate range of potential gains for enhancing the average web-browsing QoE of all the users in a mobile network with given capacity. We investigate a method that takes capacity from users during QoE insensitive periods. The gained capacity is distributed among users being in QoE affecting state. Our models of web page network prioritization show that the potential gain for QoE affecting periods highly depends on the correlation between data downloaded during QoE affecting and QoE insensitive periods. The numerical evaluation of wide range of scenarios with web traffic shows that the achievable gain is up to 104% i.e., halving the download time of QoE affecting part. Network prioritization of web pages has good potential to improve web-browsing QoE.

Topic: Green IT and Sustainability
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
[Methods and results of stereotactic radiosurgery for cavernous angiomas].

Stereotactic radiosurgery was performed in 42 patients (1997-2007). They presented with 47 cavernous angiomas and 44 of them underwent surgery. Single focal dosage varied 3-9 Gy while total one--18-54Gy. After treatment and 2-year followup, neurologic symptoms regressed in 21 (68%), tumors were smaller (MRI) in 10 (32.3%) and severe convulsions abated in 5 patients out of 9. No cerebral hemorrhage was reported within 9 years although 63.7% of tumors were located in deep cerebral structures and hemorrhage occurred as a precursor in 83%.

Topic: Vascular Malformations Diagnosis and Treatment
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
[Coamide stimulation of immunogenesis during experimental levomycetin therapy].

The effect of various doses of levomycetin on immunogenesis and capacity of coamide for stimulation of immunogenesis in levomycetin therapy was studied. It was found that massive five-fold doses of levomycetin sodium succinate (I and 0.5 g/kg) administered parenterally or orally inhibited immunogenesis, the inhibition being more pronounced on administration of the antibiotic per os. When levomycetin sodium succinate was used in massive doses (1 g/kg) in combination with coamide (0.5 mg/kg) the inhibition of the immune response to the antigenic stimulation was less pronounced.

Topic: Antifungal resistance and susceptibility
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Study on dislocation and microstructural properties of friction stir welded joint for 2024-T4 aluminum alloys

Microstructural properties and dislocation distribution of friction stir welded joint for 2024-T4 aluminum alloy were analyzed.Dislocations were mainly distributed in the grains of WNZ, mostly existed in the form of dislocation tangles and with a large number of precipitated phases.In TMAZ, dislocations existed in the grain boundary or grain interior in the form of dislocation pile-up.The dislocation density was also higher.Some dislocations existed near the grain boundary in the form of dislocation pile-up in HAZ along with some typical AlCu3 precipitated phase.In WN and TMAZ, the number and types of dislocation were not reduced along with the grain refinement because of the dynamic recovery and dynamic recrystallization process.The dislocation distribution was inconsistent with the hardness distribution of welded joints.The dislocation formed could be roughly divided into three phases: dynamic response process, dynamic recrystallization process and continuous deformation and recrystallization process.

Topic: Advanced Welding Techniques Analysis
Subfield: Mechanical Engineering
Field: Engineering
Domain: Physical Sciences
Colombia’s Constitutional Debate on Gender Quotas: The Link between Representation, Merit, and Democracy

Gendered quotas have been one of the preferred instruments for promoting women’s participation and empowerment in public decision-making positions. This study analyzes Colombia’s constitutional validation of gender quotas. It examines how ideas of merit were articulated in favor and against the enactment of gender quotas. In doing so, it argues that the centrality of merit in the constitutional debate on gender quotas is fundamentally flawed, for it ignores the subjective nature of merit, limiting the type of experiences and potential that matter in democratic representation. From this perspective, the primary idea that men and women need to show that they ‘deserve’ to occupy representative positions undermines feminist critique on representation. In this sense, the article contributes to the debate on women’s global leadership by revealing the risks of merit-driven arguments for advancing women’s democratic representation.

Topic: Comparative constitutional jurisprudence studies
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
The Anglican–Methodist Covenant: differences in the belief patterns of Anglican clergy and Methodist ministers

The Covenant between the Church of England and British Methodism now in place looks forward to a closer relationship between the two churches. An empirical study, carried out in the late spring of 2003, indicates differences in patterns of belief among the working clergy and ministers of both churches which might help or hinder further moves towards church unity.

Topic: Religion, Society, and Development
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Calcium Signaling Mechanisms in Renal Vascular Responses to Vasopressin in Genetic Hypertension

Abstract Previous blood flow studies demonstrated that arginine vasopressin (AVP) produces exaggerated renal vasoconstriction in young spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto control rats (WKY). The purpose of the present study was to determine the role of postreceptor calcium signaling pathways in AVP-induced renal vasoconstriction in vivo. Renal blood flow (RBF) was measured by electromagnetic flowmetry in anesthetized, water-loaded, 8-week-old WKY and SHR pretreated with indomethacin to avoid interactions with prostaglandins. AVP was injected into the renal artery to produce a transient 25% to 30% decrease in RBF without affecting arterial pressure. To achieve similar control levels of vasoconstriction, SHR received a lower dose (2 versus 5 ng). Coadministration of nifedipine with AVP produced dose-dependent inhibition of the AVP-induced renal vasoconstriction. Nifedipine exerted maximum inhibition by blocking 30% to 35% of the peak AVP response, indicating the involvement of dihydropyridine-sensitive voltage-dependent calcium channels. To evaluate intracellular calcium mobilization, 8-( N,N -diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) or heparin was coadministered with AVP. Each agent produced a dose-dependent inhibition of up to 65% of the maximum blood flow change produced by AVP. The degrees of inhibition produced by maximum effective doses of nifedipine and TMB-8 were additive; the combination blocked up to 85% of the response to AVP. These observations indicate that about one third of the AVP-induced constriction of renal resistance vessels is mediated by voltage-dependent L-type calcium channels responsive to the dihydropyridine nifedipine. Approximately two thirds of the change in vascular tone is due to inositol 1,4,5-trisphosphate–mediated calcium mobilization from intracellular sources sensitive to TMB-8 and heparin. The results suggest that the exaggerated renal vascular reactivity to AVP challenge in SHR is probably not due to a strain difference in postreceptor calcium signal transduction. After AVP receptor stimulation, calcium mobilization and calcium entry signaling pathways participate to similar degrees in WKY and SHR.

Topic: Ion Transport and Channel Regulation
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
CCDC 1489552: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Evaluation of metabolic parameters among health workers in terms of adherence to Mediterranean diet

Abstract Background The certain occupational risk factors, such as physical and mental stress from working conditions and poor diet, make healthcare workers(HCWs) a vulnerable group for obesity and non-communicable diseases(diabetes, dyslipidemia, etc.). Adopting a healthy and sustainable diet is very important in terms of both health and environmental impacts. The aim of this study was to evaluate metabolic parameters among HCWs in terms of adherence to the Mediterranean diet, which is shown to be a healthy and sustainable dietary model. Methods This cross-sectional study included 372 HCWs. The data collection tool consisted of the sociodemographic information of the participants, Mediterranean Diet Adherence Scale(MEDAS) questions, body mass index(BMI) and metabolic parameter information obtained retrospectively from hospital data. BMI≥30 kg/m2 and 25-29.9 kg/m2 were considered obese and overweight, respectively. Descriptive and inferential statistics were performed. Results 71% of the participants stated that they had not heard of the concept of ‘sustainable nutrition’ before. Of the HCWs who participated in the study, 65.3% were overweight or obese. It was found that 59.7% of the HCWs showed low adherence to the Mediterranean diet and 39.5% showed moderate adherence. Men(p &amp;lt; 0.001), those with high school education or less (p = 0.030) and those who did not think that they ate healthy(p = 0.001) had significantly lower compliance with the Mediterranean diet. BMI(p = 0.022) and HbA1c(p = 0.049) parameters were significantly lower and HDL parameter(p = 0.015) was higher in HCWs with moderate and high adherence to the Mediterranean diet. Conclusions It was observed that the frequency of hearing the concept of ‘sustainable nutrition’ and compliance with the Mediterranean diet was low among healthcare professionals. Also, it was found that the frequency of obesity, dyslipidemia, and high diabetes-related parameters were increased in those with low adherence to the Mediterranean diet. Key messages • National, EU and global policies should be developed to increase compliance with healthy and sustainable diets among health workers who play a key role in the provision of quality healthcare services. • Plans and programs to increase adherence to Mediterranean-type dietary patterns will bring significant increased health benefits related to non-communicable diseases and its risk factors.

Topic: Global Public Health Policies and Epidemiology
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
Chimpanzees as ecosystem service providers: Seed dispersal of an economically important plant resource

Abstract Vertebrate‐mediated seed dispersal is vital to the maintenance of diversity in tropical ecosystems, and seed‐dispersing animals are increasingly thought to provide ecosystem services by dispersing the seeds of plant species utilized by people. However, few studies have demonstrated a link between vertebrate frugivores and plants used by people, thus limiting the generalizability of the seed‐disperser‐as‐ecosystem‐service‐provider concept. We examined the effectiveness of western chimpanzees ( Pan troglodytes verus ) as seed dispersers (i.e., their influence on seedling recruitment) of an economically important fruit resource, Saba senegalensis , at the site of Fongoli, a savanna‐woodland environment in southeastern Senegal. The fruit from the Saba vine is commonly harvested from the wild by local people and is also an important food item for chimpanzees. We conducted germination experiments on gut‐passed seeds alongside non‐gut‐passed seeds and analyzed the germination success of chimpanzee‐dispersed seeds in situ. We also analyzed the effect of habitat type and canopy cover at each seed dispersal site to determine which sites are most suitable for Saba germination. Germination trials showed that chimpanzee gut passage and manual pulp removal increased the likelihood of germination over seeds left intact. Nearly a quarter of chimpanzee‐dispersed seeds germinated in situ and Saba seeds were distributed nonrandomly throughout Fongoli, with more dispersed seeds found in habitats most suitable for Saba germination. These results suggest that chimpanzees aid in the early stages of Saba recruitment and thus provide an ecosystem service via seed dispersal that may contribute to the well‐being of local people. Abstract in French is available with online material.

Topic: Primate Behavior and Ecology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
An efficient algorithm for a task allocation problem

This paper presents an efficient algorithm to solve one of the task allocation problems. Task assignment in an heterogeneous multiple processors system is investigated. The cost function is formulated in order to measure the intertask communication and processing costs in an uncapacited network. A formulation of the problem in terms of the minimization of a submodular quadratic pseudo-Boolean function with assignment constraints is then presented. The use of a branch-and-bound algorithm using a Lagrangean relaxation of these constraints is proposed. The lower bound is the value of an approximate solution to the Lagrangean dual problem. A zero-duality gap, that is, a saddle point, is characterized by checking the consistency of a pseudo-Boolean equation. A solution is found for large-scale problems (e.g., 20 processors, 50 tasks, and 200 task communications or 10 processors, 100 tasks, and 300 task communications). Excellent experimental results were obtained which are due to the weak frequency of a duality gap and the efficient characterization of the zero-gap (for practical purposes, this is achieved in linear time). Moreover, from the saddle point, it is possible to derive the optimal task assignment.

Topic: Interconnection Networks and Systems
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Characteristics of Orange-Footed Scrubfowl (Megapodius reinwardt) Nest in Tunak Montain Natural Tourism Park

Orange-footed scrubfowl (Megapodius reinwardt) is a protected animal. Especially on the island of Lombok, one of the habitats of the orange-footed scrubfowl bird is in Tunak Montain Nature Tourism Park. The condition of the nest will influence the frequency of presence of orange-footed scrubfowl. In this regard, to enrich information in its conservation, it is necessary to carry out research on the characteristics of the nests of the orange-footed scrubfowl. The aim of this research to determine the nest characteristics of the orange-footed scrubfowl in Tunak Montain Nature Tourism Park. The method used is direct measurement and observation in the field. The results of the research show that the nest of the orange-footed scrubfowl bird is in the form of a mound of earth composed of leaves, branches, tree twigs, sand and rocks. The height of the nest mound ranges from 57-160 cm, and the diameter of the nest mound is 500-1,030 cm. The number of holes in each nest varies, namely between 5-9 holes, with a hole depth of 67-142 cm and a nest hole diameter of 30-41 cm. The dominant factors of the abiotic component of the nest that have a singular influence on the presence of orange-footed scrubfowl are distance to the river channel and number of predators. The tendency to choose a nesting area based on the results of Chi-Square analysis is influenced by five variables, namely, distance to the river, soil texture, altitude, temperature and number of predators around the nest.

Topic: Livestock Farming and Management
Subfield: Agronomy and Crop Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Skin Corrosion In Vitro: Assessment of the SkinEthic® Reconstituted Human Epidermal (RHE) model for in vitro skin corrosion testing according to OECD TG 431

In 2002 the National Co-ordinators of OECD Test Guideline Programme (WNT) endorsed a New Draft Test Guideline TG 431 (Human Skin Model) for In Vitro Skin Corrosion Testing which was finally adopted in April 2004. This guideline specifies general functional and performance criteria that have to be met, if a new skin or epidermal model is intended to be used for the skin corrosion testing of chemicals in vitro.In 2003 ZEBET tested several chemicals with known corrosive potential on the SkinEthic reconstituted human epidermal (RHE) model using the validated EpiDerm test protocol and prediction model. After minor technical adaptations, classifications obtained were comparable to those obtained previously with the validated human skin models EPISKIN and EpiDerm.From December 2003 to February 2004 ZEBET, SafePharm and BASF conducted an inter-laboratory trial with 12 coded reference chemicals proposed by the OECD TG 431 in order to confirm the performance of the SkinEthic skin corrosion assay.In each laboratory, for each of the test chemicals, three independent tests were performed. Results obtained with the SkinEthic epidermal model were reproducible, both within and between laboratories, and over time. Concordance between the in vitro predictions of skin corrosivity potential obtained with the SkinEthic epidermal model and the predictions obtained with the accepted skin models was very good. The new test was able to correctly distinguish between corrosive and non-corrosive reference chemicals and can be regarded as valid method for the use in context with OECD TG 431.

Topic: Animal testing and alternatives
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences