jimnoneill/paper-to-field-training huggingface dataset:
Phase 1b dose-escalation and cohort-expansion study of the safety, tolerability, and efficacy of a novel transforming growth factor-β receptor I kinase inhibitor (galunisertib [G]) administered in combination with the anti-PD-L1 antibody (durvalumab [D]) in recurrent or refractory metastatic pancreatic cancer.

TPS501 Background: Transforming growth factor-β (TGF-β) can suppress adaptive and innate anti-tumor immune responses. G (LY2157299) is an oral small molecule inhibitor of TGF-β receptor I kinase that down-regulates phosphorylation of SMAD2, abrogating activation of the canonical pathway. Programmed cell death-ligand 1 (PD-L1) is upregulated in a broad range of cancers including pancreatic; expression of PD-L1 helps tumors evade immune system detection through binding to PD-1 on cytotoxic T lymphocytes. D (MEDI4736) is an anti-PD-L1 monoclonal antibody that blocks PD-L1/PD-1 interactions. Blockade of both TGF-β and PD-L1 pathways could reverse immunosuppression associated with these molecules by activating adaptive and innate anti-tumor immune responses. Methods: This two part phase 1b open-label study will enroll patients (pts) with recurrent or refractory metastatic pancreatic cancer. Part 1 is a 3+3 dose-escalation assessment of the safety and tolerability of G (4 escalating doses) and D (constant dose). After dose-limiting toxicity evaluation, cohort expansion with approximately 25 pts at the dose determined in the dose escalation portion will occur. Eligible pts have recurrent or refractory metastatic pancreatic cancer ( ≤ 2 prior systemic regimens) regardless of PD-L1 status; ECOG PS 0-1. Pts who have received prior therapy targeting T-cell costimulation or checkpoint pathways, or have received a TGF-β R1 kinase inhibitor are not eligible. Pretreatment and on-treatment biopsies will be obtained. The primary objective is to assess safety and tolerability of G in combination with D by identifying dose-limiting toxicities and to assess safety of the combination at the dose-escalation-established dose. Secondary objectives are pharmacokinetics; immunogenicity; preliminary anti-tumor activity; overall survival. Exploratory objectives are to examine biomarkers relevant to G, D, and the disease state. Enrollment began on 15-June-2016; as of 13-Sep-2016, 1 pt entered treatment. Clinical trial information: NCT02734160.

Topic: Pancreatic and Hepatic Oncology Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Analyzing Public Concerns on Mpox Using Natural Language Processing and Text Mining Approaches

The World Health Organization (WHO) officially designated Mpox (Monkeypox) as a Public Health Emergency of International Concern on July 23, 2022. Since early May 2022, numerous endemic countries have been reporting the spread of Mpox, with alarming mortality rates have accompanied. This situation has prompted extensive discussions and deliberations among the general public through various social media platforms and health forums.This study proposes a natural language processing approach, specifically employing topic modeling techniques, to extract and analyze the public sentiments and perspectives regarding the escalating Mpox cases on a global scale. The results revealed several themes related to Mpox transmission, such as Mpox symptoms, international travel, government interventions, and homophobia from the user-generated content. The results further confirm that the general public has many stigmas and fears about the Mpox virus, which is prevalent in almost all topics.

Topic: Poxvirus research and outbreaks
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Flexibility services for household consumers in Finland: Requirements and provided properties

The ability to shift energy consumption to a time when a lot of energy is available supports the integration of renewable energy sources. Services that intend to do this automatically are currently emerging in the markets. These kinds of flexibility services are targeted as smart services to household consumers, promising them cost savings, optimal living conditions, and other benefits. The purpose of this paper is to examine the current demand and offering of these kinds of services in Finland. We performed an extensive consumer survey to untangle consumers' potential, motivation, and engagement in flexibility services and surveyed the properties, similarities, and differences of the flexibility services in the markets. We then defined a quality dimensions framework for flexibility services, with which we evaluated the results to understand the required properties of the services from a consumer viewpoint and how the services respond to these requirements. The results show that Finnish household consumers are quite willing and ready for these kinds of services, and several services are currently available that fulfill some of the identified requirements. Most of the services are currently provided to larger customers, but it should be noted that there also exists demand among individual households. Therefore, clearer incentives, unambiguous definitions of responsibilities, and effortless service introductions are required to motivate consumer participation.

Topic: Service and Product Innovation
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
Expression of Human Endogenous Retroviruses (HERVs) in Breast Cancer: A Transcriptomic Study

Background: Human endogenous retroviruses (HERVs) are ancient viral elements inte-grated into the human genome, accounting for approximately 8% of its content. Recent findings suggest that HERVs, especially HERV-K (HML-2), play a significant role in the onset and advancement of breast cancer. Understanding HERV expression patterns could reveal new biomarkers and therapeutic targets in breast cancer. This study examined the expression of endogenous retroviruses in human breast tissues, to reveal potential associations between retroviruses and breast cancer. Methods: RNA-Seq datasets from breast cancer tissues (ductal carcinoma and triple-negative subtypes) and normal breast tissues were retrieved from the NCBI Sequence Read Archive (SRA). Bioinformatics analysis included read mapping against the human genome (hg19) and a custom pseudogenome containing HERV sequences. Normalized expression of HERV-human junctions was calculated and statistical comparisons were performed using independent samples t-tests and Mann-Whitney tests. Results: Breast cancer tissues exhibited signifi-cantly higher normalized coverage of HERV integration sites compared to healthy con-trols (p=0.009). Among breast cancer cases, patients who had undergone treatment showed significantly lower HERV expression than untreated patients (p=0.023). Visuali-zation via IGV confirmed increased read accumulation at HERV loci in cancer samples. Conclusion: This study showed that HERVs are overexpressed in breast cancer tissues compared to normal breast tissues, with expression levels influenced by therapeutic in-terventions. These findings support the potential role of HERVs as biomarkers for breast cancer diagnosis, prognosis, and therapeutic monitoring. Further research is warranted to explore HERV-targeted strategies for breast cancer treatment.

Topic: Virus-based gene therapy research
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Correlations of Precursor and Carbon Coating with Electrochemical Property of 2D Graphitic Carbon Nitride (g-C<sub>3</sub>N<sub>4</sub>) Nanosheets as High-Reversibility Cathode of Nonaqueous Al-Ion Batteries

Al-ion batteries (AIBs) represent promising multivalent-ion battery alternatives to Li-ion batteries (LIBs). Exploration of cathode materials is the key to improving the electrochemical performance of AIBs. Here we demonstrate a promising AIB cathode candidate based on two-dimensional graphitic carbon nitride (g-C3N4) nanosheets with reversible de/embedding of [AlCl4]− anions in its special layered porous structure during the cyclic charge/discharge process. To address the sluggish ion/charge transportation kinetics that is inherently present in AIBs due to the intrinsically low conductivity of g-C3N4, we optimize different synthetic precursors of g-C3N4 including dicyandiamide, urea, and melamine and, further, develop a facile method for uniformly coating a N-doped carbon (N–C) coating layer on the optimal g-C3N4 derived from dicyandiamide. The resultant AIBs consisting of the g-C3N4@N–C cathode and Al metal anode in the AlCl3/[EMIm]Cl electrolyte exhibit an initial capacity of ∼54.9 mAh·g–1 at 0.2 C with a high Coulomb efficiency ∼99.9%, and they possess long-term cycling over 200 cycles. The underlying charge/discharge process of AIBs, revealed by the ex situ X-ray diffraction and scanning electron microscopy analyses, involves the extraction/insertion of Al species (mainly Al3+, AlCl4–, and Al2Cl7–) into the g-C3N4 crystal lattices with the formation of intermediate Al8C3N4 and (ClCN)3.

Topic: Advancements in Battery Materials
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Efficient <i>p53</i> gene targeting by homologous recombination in rat‐induced pluripotent stem cells

Abstract Objectives To generate rat induced pluripotent stem cells ( iPSC s) using the PiggyBac (PB) transposon system, and to explore whether these iPSC s would be amenable to genetic manipulation. Materials and methods The PB transposon system was used to reprogramme rat embryonic fibroblasts (EF) to become iPSC s. Cells were identified with regard to pluripotency and differentiation capacity in vitro and in vivo , population growth characteristics and gene expression; furthermore, targeting vector was electroporated into them. Correct recombination colonies were acquired by positive and negative selection, and then phenotype confirmed by Southern blotting. Results The rat EF cells were reprogrammed into iPSC s successfully, using the PB transposon system. Cell morphology was found to display characteristics of rat embryonic stem cells (ESCs) and results of immunofluorescence staining and PCR indicated that they expressed pluripotency markers. In vivo and in vitro differentiation experiments proved that the cells could differentiate into all phenotypes from three germ layers, and to form chimaeras with high rat iPSC contribution. After electroporation with p53 targeting vector, approximately (5.44 ± 0.74) × 10 −6 colonies tolerated selection. Southern blotting confirmed that p53 gene was targeted successfully in the colonies. Conclusion The PB transposon system proved to be an effective method for reprogramming of rat EF cells into iPSC s. The rat iPSC s were amenable to gene targeting mediated by routine homologous recombination.

Topic: Pluripotent Stem Cells Research
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The nucleoprotein content of fibroblasts growing <i>in vitro</i>. 4. Changes in the ribonucleic acid phosphorus (RNAP) and deoxyribonucleic acid phosphorus (DNAP) content

Research Article| January 01 1949 The nucleoprotein content of fibroblasts growing in vitro. 4. Changes in the ribonucleic acid phosphorus (RNAP) and deoxyribonucleic acid phosphorus (DNAP) content J. N. Davidson; J. N. Davidson 1Biochemistry Department, St Thomas's Hospital Medical School, London, S.E. 1 Search for other works by this author on: This Site PubMed Google Scholar I. Leslie; I. Leslie 1Biochemistry Department, St Thomas's Hospital Medical School, London, S.E. 1 Search for other works by this author on: This Site PubMed Google Scholar Charity Waymouth Charity Waymouth 1Biochemistry Department, St Thomas's Hospital Medical School, London, S.E. 1 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1949) 44 (1): 5–17. https://doi.org/10.1042/bj0440005 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation J. N. Davidson, I. Leslie, Charity Waymouth; The nucleoprotein content of fibroblasts growing in vitro. 4. Changes in the ribonucleic acid phosphorus (RNAP) and deoxyribonucleic acid phosphorus (DNAP) content. Biochem J 1 January 1949; 44 (1): 5–17. doi: https://doi.org/10.1042/bj0440005 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1949 CAMBRIDGE UNIVERSITY PRESS1949 Article PDF first page preview Close Modal You do not currently have access to this content.

Topic: Folate and B Vitamins Research
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
The hidden locality in swarms

People use P2P systems such as BitTorrent to share an unprecedented variety and amount of content with others around the world. The random connection pattern used by BitTorrent has been shown to result in reduced performance for users and costly cross-ISP traffic. Although several client-side systems have been proposed to improve the locality of BitTorrent traffic, their effectiveness is limited by the availability of local peers. We show that sufficient locality is present in swarms - if one looks at the right time. We find that 50% of ISPs have at least five local peers online during the ISP's peak hour, typically in the evening, compared to only 20% of ISPs during the median hour. To better discover these local peers, we show how to increase the overall peer discovery rate by over two orders of magnitude using client-side techniques: leveraging additional trackers, requesting more peers per sample, and sampling more frequently. We propose an approach to predict future availability of local peers based on observed diurnal patterns. This approach enables peers to selectively apply these techniques to minimize undue load on trackers.

Topic: Peer-to-Peer Network Technologies
Subfield: Computer Networks and Communications
Field: Computer Science
Domain: Physical Sciences
Cardiorespiratory responses to stationary running in water and on land.

The aim of the study was to compare maximal and submaximal cardiorespiratory responses between progressive tests on a treadmill on land (TRE), and stationary running on land (SRL) and in water (SRW), while also comparing two methods of determining the second turn point (ST) (ventilatory curve and heart rate deflection point). The study sample consisted of nine active women (23 ± 1.94 years) that performed three maximal protocols in separate days. Heart rate (HR) and oxygen uptake (VO2) were measured in all sessions. The data were analyzed using repeated-measures ANOVA and two-way repeated measures ANOVA with post-hoc Bonferroni test. Greater values of maximal HR (HRmax) and HR at ST (HRST) were observed during exercise performed on TRE and during the SRL, compared to the SRW (p < 0.05). The results for maximal VO2 (VO2max) and VO2 at ST (VO2ST) showed greater and significant values on TRE compared to STL and STW (p < 0.05). Furthermore, the HR and VO2 corresponding to the ST showed similar values between the two methods. Thus, the main conclusion of the present study was that the HR deflection point seems to be a simple and practical alternative method for determining the ST in all protocols analyzed. Key PointsThe maximal and submaximal (second turn point) oxygen uptake were influenced by the type of exercise, as these responses were similar in both water-based and land-based stationary running protocols and different from those obtained during the treadmill running, that presented greater values compared with both stationary running protocols.The heart rate deflection point can be used for determining the second turn point during stationary running test in aquatic environment.Caution is necessary in the interpretation of the application of the heart rate deflection point in water aerobics exercises because we analyzed only young women performing one water-based exercise.

Topic: Cardiovascular and exercise physiology
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
[Methods of dosimetry in evaluation of electromagnetic fields' biological action].

Theoretical and experimental dosimetry can be used for adequate evaluation of the effects of radiofrequency electromagnetic fields. In view of the tough electromagnetic environment in aircraft, pilots' safety is of particular topicality. The dosimetric evaluation is made from the quantitative characteristics of the EMF interaction with bio-objects depending on EM energy absorption in a unit of tissue volume or mass calculated as a specific absorbed rate (SAR) and measured in W/kg. Theoretical dosimetry employs a number of computational methods to determine EM energy, as well as the augmented method of boundary conditions, iterative augmented method of boundary conditions, moments method, generalized multipolar method, finite-element method, time domain finite-difference method, and hybrid methods combining several decision plans modeling the design philosophy of navigation, radiolocation and human systems. Because of difficulties with the experimental SAR estimate, theoretical dosimetry is regarded as the first step in analysis of the in-aircraft conditions of exposure and possible bio-effects.

Topic: Electromagnetic Fields and Biological Effects
Subfield: Biophysics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium

These observations revealed that the NLRP3 inflammasome activation in infiltrating macrophages contributes to corneal fibrosis by regulating corneal epithelial TGF-β1 expression. Targeting the NLRP3 inflammasome might be a promising strategy for the treatment of corneal scarring.

Topic: Ocular Surface and Contact Lens
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Effect of Garcinia Kola in Ivermectin-Induced Toxicity in the Hematology of Treated Rats (Rattus Novergicus)

Garcinia kola (GK) is prized in African herbal medicine for its diverse uses, including social, economic, and medicinal purposes. This study examined the dose-dependent toxicity of ivermectin and the protective effects of Garcinia kola extract on the hematological parameters of Wistar rats. A total of 32 Wistar Rats (120 – 150g) were randomly chosen from PAMO University of Medical Sciences' Animal House. They were acclimatized for two weeks. Divided into 4 main groups (A, B, C, D), which were further subdivided into 2 subgroups each (A1, A2, B1, B2, C1, C2, D1 and D2) with each subgroup containing 4 rats. Subgroup A: negative control (0 mg/kg BW of ivermectin, no Garcinia kola). Subgroup A2: positive control (0 mg/kg BW of ivermectin and 20 mg/kg/ml Garcinia kola). Test Subgroups 1 (B1, C1 and D1) received respectively doses of 10 mg/kg/ml, 20 mg/kg/ml, and 40 mg/kg/ml of Ivermectin intraperitoneally, Subgroups 2 (B2, C2 and D2) received respectively the same doses followed by oral administration of Garcinia kola at 20 mg/kg BW of rat per ml daily for 7 days, starting 24 hours after toxicity induction. On the eighth day, each rat was anesthetized with chloroform. 5mls of blood was collected via cardiac puncture into EDTA bottle for the analysis of the CBC parameters. ANOVA was used to test the hypotheses at alpha = 0.05. The result showed a significant dose-dependent difference in anaemia indicators in ivermectin induction but there was no significant change in after bitter kola treatment. The study has shown that ivermectin inflicted haematological toxicity particicular in particular in anaemic indicators but bitter kola couldn’t ameliorate the effect of the toxicity.

Topic: Natural Compound Pharmacology Studies
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Occurrence Download

A dataset containing 5228490 species occurrences available in GBIF matching the query: { "TaxonKey" : [ "is Bivalvia" ] } The dataset includes 5228490 records from 2461 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0048840-231002084531237/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.

Topic: Toxoplasma gondii Research Studies
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Discipline and teaching of art education in the five grades of primary school

The undergraduate thesis examines the occurrence of inappropriate behavior in a classroom and identifies student discipline in art education and its impact on execution of classes.&#13;\n&#13;\nThe theoretical part presents the definition of discipline and its types, classroom management, misconduct, teacher's discipline approach, the impact of family education and the course of art classes.&#13;\n&#13;\nThe practical part describes two school lessons with preparation and their analysis. Each lesson is analyzed in the table on the occurrence of observational criteria as well as presented with percentage of the number of students. All the results are joined into a common table and analyzed. According to the latter research questions have been confirmed or refuted.&#13;\n&#13;\nResearch questions relate to teaching art, teacher's conduct during classes, teacher's impact on students’ discipline and the effect of selecting fine tasks, visual motif and work forms on students’ discipline.&#13;\n&#13;\nAs a future teacher, I wanted to explore how much is discipline presented in art education and what affects it. I prepared two lessons with different artistic tasks. In the implementation I used different work forms as well as different work methods. The analysis of lessons and tables shows that teacher's preparation for the lesson is crucial along with monitoring and guiding students through all steps in their learning.&#13;\n

Topic: Art Education and Development
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Photosynthesis and growth of young “Niágara Branca” vines (

\nThe objective of this study was to evaluate the photosynthetic response and growth of young grape “Niagara Branca” vines grown in soil with high content of Cu and liming. The experiment was conducted in controlled environment with soil subjected to three levels of liming, with 0, 1.5 and 3.0 Mg ha−1 of lime. The effect of additional 50 mg kg−1 Cu in half of soil treatments was evaluated. The CO2 measurements, assimilation rate, stomatal conductance and transpiration were carried out in the tenth cultivation week using the IRGA equipment (Infrared Gaz Analyzer). Plant height, fresh weight and dry weight, concentration of chlorophyll a, chlorophyll b, total chlorophyll, and carotenoids were measured. For most variables, the Cu had damaging effect on 0 and 1.5 Mg ha−1 liming treatments however, there was no significant damage in the 3.0 Mg ha−1 treatment. Rates of CO2 assimilation, stomatal conductance, and transpiration were increased with the addition of 50 mg kg−1 Cu. Liming to raise the pH of the soil is an effective practice to reduce the effects of Cu toxicity in young “Niagara Branca” grape vines.\n

Topic: Horticultural and Viticultural Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences