jimnoneill/paper-to-field-training huggingface dataset:
Cutaneous DNA Vaccination Against Ebola Virus by Particle Bombardment: Histopathology and Alteration of CD3-positive Dendritic Epidermal Cells

We analyzed the localization of gold particles, expression of immunogenic protein, and histopathologic changes after vaccinating guinea pigs and mice with a DNA vaccine to the Ebola virus glycoprotein administered by cutaneous particle bombardment. Gold particles were deposited in all layers of the epidermis and in the dermis. Those in the epidermis were lost as the damaged layers sloughed, while those in the dermis were phagocytized by macrophages. Glycoprotein was demonstrated by immunohistochemistry primarily in keratinocytes in the epidermis and hair follicle epithelium and less frequently in dermal macrophages, fibroblasts, sebocytes, and cells that appeared to be Langerhans cells. The number of cells that expressed glycoprotein increased between 4 and 8 hours postvaccination, then decreased to near zero by 48 hours. The vaccine sites were histologically divisible into three zones. The central portion, zone 1, contained the most gold particles in the dermis and epidermis and had extensive tissue damage, including full-thickness epidermal necrosis. Zone 2 contained fewer gold particles in the epidermis and dermis and had less extensive necrosis. The majority of cells in which glycoprotein was expressed were in zone 2. Zone 3 contained gold particles only in the epidermis and had necrosis of only a few scattered cells. Regeneration of the epidermis in damaged areas was evident at 24 hours postvaccination and was essentially complete by day 5 in the mice and day 10 in the guinea pigs. Inflammatory changes were characterized by hemorrhage, edema, and infiltrates of neutrophils initially and by infiltrates of lymphocytes and macrophages at later times. In zone 1, inflammation affected both the epidermis and dermis. Peripherally, inflammation was relatively limited to the epidermis. CD3-positive dendritic epidermal cells were demonstrated in the epidermis and superficial hair follicles of unvaccinated immunocompetent mice and beige mice but not of SCID mice. These cells disappeared from all but the most peripheral portions of the vaccine sites of vaccinated mice within 24 hours. They reappeared slowly, failing to reach numbers comparable with unvaccinated mice by 35 days postvaccination. The epidermis of control guinea pigs also had CD3-positive cells, but they did not have dendrites. These findings should contribute to a better understanding of the mechanisms operating in response to DNA vaccination by particle bombardment.

Topic: Viral Infections and Outbreaks Research
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Benign papillary mesothelioma of the tunica vaginalis testis.

We report a case of benign mesothelioma of the tunica vaginalis testis in a 69-year-old man who presented with a 4-month history of scrotal swelling. A polypoid pedunculated nodule, 1.5 cm in diameter, was found near the head of the right epididymis. Histologically, the tumor exhibited features characteristic of a well-differentiated papillary mesothelioma. The mesothelial origin of this tumor was further supported by immunohistochemical analysis. The tumor cells exhibited nuclear p53 protein accumulation, despite the benign histologic findings and a 3-year uneventful follow-up after resection. A polymerase chain reaction analysis for simian virus 40 DNA was negative. The papillary configuration seen in this tumor is uncommon for this site, inasmuch as benign mesotheliomas of the tunica vaginalis testis usually exhibit an adenomatous pattern. One should be aware of this pattern, and benignity should be mentioned in the pathologic report to prevent overtreatment. In addition, positive p53 immunohistochemical staining should not be taken automatically as evidence for malignancy in this type of lesion.

Topic: Occupational and environmental lung diseases
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Supplementary Methods S1 from A Phase Ib Study of the DNA-PK Inhibitor Peposertib Combined with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer

&lt;p&gt;Supplementary methods and results with references&lt;/p&gt;

Topic: Colorectal and Anal Carcinomas
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
On-Board Vision-Language Models for Personalized Autonomous Vehicle Motion Control: System Design and Real-World Validation

Personalized driving refers to an autonomous vehicle's ability to adapt its driving behavior or control strategies to match individual users' preferences and driving styles while maintaining safety and comfort standards. However, existing works either fail to capture every individual preference precisely or become computationally inefficient as the user base expands. Vision-Language Models (VLMs) offer promising solutions to this front through their natural language understanding and scene reasoning capabilities. In this work, we propose a lightweight yet effective on-board VLM framework that provides low-latency personalized driving performance while maintaining strong reasoning capabilities. Our solution incorporates a Retrieval-Augmented Generation (RAG)-based memory module that enables continuous learning of individual driving preferences through human feedback. Through comprehensive real-world vehicle deployment and experiments, our system has demonstrated the ability to provide safe, comfortable, and personalized driving experiences across various scenarios and significantly reduce takeover rates by up to 76.9%. To the best of our knowledge, this work represents the first end-to-end VLM-based motion control system in real-world autonomous vehicles.

Topic: Robotic Path Planning Algorithms
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Queer Appearances: Gilbert &amp; George's Visual Strategies

The use that visual artists have made of popular media, such as television, has provided a point of critical interest over recent decades. Contemporary artists, Gilbert &amp; George, followed the pace set by media-savvy artists, through their recent television appearance on the popular talk-show Friday Night with Jonathan Ross. Their appearance on prime-time TV raised a series of questions concerning gay visibility, mainstream media and the visual subterfuge deployed in contemporary art. This article seeks to examine such issues against the background of political struggles over public and private space.

Topic: Art, Politics, and Modernism
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Thermodynamic analysis for bioconvection peristaltic transport of nanofluid with gyrotactic motile microorganisms and Arrhenius activation energy

Improving high-efficiency thermal systems to increase heat transmission has become quite prevalent nowadays. Various works were conducted to gain insight into the implementation of heat transfer for their practical use in increasing heat transfer. Therefore, the present study focuses on analyzing heat exchange and irreversibility rate (entropy generation) for bioconvection peristaltic transport of nanofluid with mass transfer. Investigation takes place inside an asymmetrical channel with flow subject to the action of gyrotactic motile microorganisms and Arrhenius activation energy. The considered flow situation is sculpted via Brownian diffusion, variable viscosity, nonuniform heat generation/absorption, viscous dissipation, porous medium, mixed convection, and thermophoresis diffusion assumptions. Lubrication approximations have been used in this modelling. Numerical computations of the governing equations along with related conditions are conducted using NDSolve in Mathematica. Quantities of physical interest such as temperature distribution, entropy production, concentration, density of motile microorganism and velocity profiles are computed and depicted through tables and graphs to demonstrate the effects of the related parameters. The results revealed that temperature distribution suppresses for higher activation parameters. Heat transfer rate at wall decreases for higher viscosity parameter. To minimize the generation of entropy in the system, we need to increase the porosity parameter. It is also found that the density of motile microorganism decreases for higher bioconvection Peclet number. Moreover, fluid motion strongly advanced by enhancing the Bioconvection Rayleigh number and buoyancy ratio parameter. Water-based nanofluid provides better heat and irreversibility properties as compared to methanol based nanofluid.

Topic: Nanofluid Flow and Heat Transfer
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
CCDC 922619: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Topic: Crystallization and Solubility Studies
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
THE DESIGN OF NEW DIGITAL ARTEFACTS AS KEY FACTOR TO INNOVATE THE TEACHING AND LEARNING OF ALGEBRA: THE CASE OF ALNUSET

The integration of CAS systems into school practices of algebra is marginal. To integrate effectively digital technology in the teaching and learning of algebra, it is necessary to go beyond the experience of CAS and of their instrumented techniques and to face the design of new artefacts. In this paper we discuss design problems faced in the development of a new digital artefact for teaching and learning of algebra, the Alnuset system. We present the key ideas that have oriented its design and the choices we have worked out to instrument its incorporated algebraic techniques. We compare the quantitative, symbolic and functional instrumented techniques of Alnuset with those of CAS highlighting crucial differences in the teaching and learning of algebra.

Topic: Mathematics Education and Teaching Techniques
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Mondrian, Eye Movements, and the Oblique Effect

Observers prefer Mondrian's paintings in their original orientation compared to when rotated—“the oblique effect” (Latto et al, 2000 Perception29 981–987). We tested whether eye movements could provide any insight into this aesthetic bias. While recording fixation duration and saccade length, we presented eight Mondrian paintings dated 1921–1944 on a CRT in either their original or seven rotated positions to ten observers who used a Likert scale to report how (dis)pleasing they found each image. We report on eye-movement patterns from nine pairs of images that had a significant orientation effect. During the 20 s scans, fixation durations increased linearly, more so for pleasing images than for non-pleasing images. Moreover, saccade distances oscillated over the viewing interval, with larger saccade-distance oscillations for the pleasing images than the non-pleasing images. Both of these findings agree with earlier work by Nodine et al (1993 Leonardo26 219–227), and confirm that as an abstract painting becomes more aesthetically pleasing, it shows both a greater amount of diversive/specific types of image exploration and balance. Thus, any increase in visual fluency in localizing vertical and horizontal versus oblique lines can lead to an increase in the aesthetic pleasure of viewing Mondrian's work.

Topic: Aesthetic Perception and Analysis
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Gut Effect on Phytochemicals

The gut microbiota play an important role for host nutritional, physiological, immunological functions like food digestion, vitamin production, protection of gut integrity, regulation of host immunity, and disease pathogenesis. Dietary phytochemicals are important factors to shape and change the human gut microbiota composition in diversity and abundance context. On the other hand, the microbial community of the gut provides a broad range of enzymes to host which are different from its own resources. This enables human gut microbiota to affect and direct the biosynthesis and metabolism of many bioactive compounds. Bioavailability of phytochemicals is important to benefit from health conferring effects of these compounds. Most of the phytochemicals are not absorbed well by the small intestine and pass through to the gut then gut microbiota acts on the compounds to form different metabolites. Therefore, elucidating the role of human gut microbiota on phytochemical metabolism is essential. This chapter discusses the studies reporting the gut microbial effect on different phytochemicals.

Topic: Gut microbiota and health
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Nonverbal communication during early childhood

important area of study for psychologists, educators, sociolinguists, psycholinguists and others interested in the acquisition and development of language in young children. Nonverbal communication plays a major role in the early socialization of young children in their cognitive growth. In addition, certain aspects of nonverbal communication ability constitute the basis for children's acquisition and development of verbal or linguistic behavior (ohnson & Myklebust, 1967; Bates, 1976; Moerk, 1977). By studying nonverbal communication, researchers, teachers and others interested in the development of language will gain a more thorough understanding of children's communicative development. Although there is widespread interest in young children's nonverbal communication, the field of study is in its infancy. Compared with the plethora of literature and research on adult nonverbal communi-

Topic: Language Development and Disorders
Subfield: Developmental and Educational Psychology
Field: Psychology
Domain: Social Sciences
Experimental Creation of Contemporary Dance Works Using a Body-part Motion Synthesis System

We developed a body-part motion synthesis system (BMSS) that synthesizes 3D motion data captured from performances of professional dancers to support the creation of contemporary dance works. To evaluate the usefulness of the system, three professional choreographers created their original dance works experimentally using the BMSS three times, and dancers performed their works in theaters. By analyzing the sequence data created by the BMSS obtained through an interview with the choreographers, we found that the choreographers could discover a variety of uses for the BMSS by becoming proficient in its use. The characteristics of the choreography created by each choreographer were also clarified.

Topic: Human Motion and Animation
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Introduction To Cyber Forensic Psychology: Understanding The Mind Of The Cyber Deviant Perpetrators

"This edited book, Introduction to Cyber Forensic Psychology: Understanding the Mind of the Cyber Deviant Perpetrators, is the first of its kind in Singapore, which explores emerging cybercrimes and cyber enabled crimes. Utilising a forensic psychology perspective to examine the mind of the cyber deviant perpetrators as well as strategies for assessment, prevention, and interventions, this book seeks to tap on the valuable experiences and knowledge of leading forensic psychologists and behavioural scientists in Singapore.Some of the interesting trends discussed in this book include digital self-harm, stalkerware usage, livestreaming of crimes, online expression of hate and rebellion, attacks via smart devices, COVID-19 related scams and cyber vigilantism. Such insights would enhance our awareness about growing pervasiveness of cyber threats and showcase how behavioural sciences is a force-multiplier in complementing the existing technological solutions"--Publisher's website

Topic: Deception detection and forensic psychology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: Insights from a large international observational study

Abstract Background His‐bundle pacing (HBP) provides physiological ventricular activation. Observational studies have demonstrated the techniques’ feasibility; however, data have come from a limited number of centers. Objectives We set out to explore the contemporary global practice in HBP focusing on the learning curve, procedural characteristics, and outcomes. Methods This is a retrospective, multicenter observational study of patients undergoing attempted HBP at seven centers. Pacing indication, fluoroscopy time, HBP thresholds, and lead reintervention and deactivation rates were recorded. Where centers had systematically recorded implant success rates from the outset, these were collated. Results A total of 529 patients underwent attempted HBP during the study period (2014‐19) with a mean follow‐up of 217 ± 303 days. Most implants were for bradycardia indications. In the three centers with the systematic collation of all attempts, the overall implant success rate was 81%, which improved to 87% after completion of 40 cases. All seven centers reported data on successful implants. The mean fluoroscopy time was 11.7 ± 12.0 minutes, the His‐bundle capture threshold at implant was 1.4 ± 0.9 V at 0.8 ± 0.3 ms, and it was 1.3 ± 1.2 V at 0.9 ± 0.2 ms at last device check. HBP lead reintervention or deactivation (for lead displacement or rise in threshold) occurred in 7.5% of successful implants. There was evidence of a learning curve: fluoroscopy time and HBP capture threshold reduced with greater experience, plateauing after approximately 30‐50 cases. Conclusion We found that it is feasible to establish a successful HBP program, using the currently available implantation tools. For physicians who are experienced at pacemaker implantation, the steepest part of the learning curve appears to be over the first 30‐50 cases.

Topic: Cardiac pacing and defibrillation studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Stoics On Souls And Demons: Reconstructing Stoic Demonology

The Stoic cosmos is determined by a single perfectly rational and provident force, ordering everything for the best; its inherent order, which is intelligible to humans, is both the source of, and perfect example for, human rationality. This chapter investigates whether and to what extent anything like an appropriation of aspects of traditional demonology was effected in Stoicism. It charts the evidence, reconstruct the outlines of underlying theory, and signal some problems and developments. The chapter offers a survey of various conceptions of demons that were around in the pre-Hellenistic religious and philosophical traditions, and of the various functions assigned to them. It examines the way in which Stoics adopted and incorporated elements from this tradition, and the extent to which their attitude changed in the course of the history of the school. It also discusses how the early Stoics conceived of the possibility of the souls survival after death. Keywords: death; demonology; demons; Hellenistic; philosophical traditions; reconstruct; soul; Stoic

Topic: Classical Philosophy and Thought
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
The Efficiency of the Online Academic Teaching Process During the Pandemic Covid-19

"This article aims to identify the efficiency of the online academic teaching process during the Sars COV- 2 pandemic, but also identify the main factors which negatively influence the online academic teaching process. The study is based on quantitative research, the data of which were collected by applying an online questionnaire to students at the Faculty of Political, Administrative and Communication Sciences in Cluj-Napoca between 01.06.2020-01.07.2020. The results of the study indicate that, during the pandemic, the efficiency of the online teaching process is below the level of the classic teaching process and is negatively influenced by a number of factors (lack of knowledge and technical information held by students / teachers on online teaching platforms, resistance to change of students / teachers (fear of something new (scary) - feeling rejected by the new because you think you can’t cope or may have negative effects or repercussions for you, etc.). However, in order for the online teaching process to be successful, a greater importance should be given to the transfer of responsibility process: focusing on the individual learning process or on the continuous improvement of the online academic teaching process. This transfer can lead inherently and implicitly to an increase in the degree dissatisfaction."

Topic: Technology-Enhanced Education Studies
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Data from [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A&lt;sub&gt;4&lt;/sub&gt; Hydrolase

&lt;div&gt;Abstract&lt;p&gt;[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A&lt;sub&gt;4&lt;/sub&gt; hydrolase (LTA&lt;sub&gt;4&lt;/sub&gt;H) protein is regarded as a relevant target for cancer therapy. Our &lt;i&gt;in silico&lt;/i&gt; prediction using a reverse-docking approach revealed that LTA&lt;sub&gt;4&lt;/sub&gt;H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA&lt;sub&gt;4&lt;/sub&gt;H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth &lt;i&gt;in vivo&lt;/i&gt; in nude mice, an effect that was mediated by inhibition of LTA&lt;sub&gt;4&lt;/sub&gt;H activity. Collectively, these findings indicate a crucial role of LTA&lt;sub&gt;4&lt;/sub&gt;H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA&lt;sub&gt;4&lt;/sub&gt;H for the prevention of colorectal cancer. [Cancer Res 2009;69(13):5584–91]&lt;/p&gt;&lt;/div&gt;

Topic: Ginger and Zingiberaceae research
Subfield: Pharmacology
Field: Pharmacology, Toxicology and Pharmaceutics
Domain: Life Sciences