jimnoneill/paper-to-field-training huggingface dataset:
A Non-Parametric Density Estimation Approach to Measuring Beam Cooling in MICE

The goal of the international Muon Ionization Cooling Experiment (MICE) is to demonstrate muon beam ionization cooling for the first time. It constitutes a key part of the R&amp;D towards a future neutrino factory or muon collider. The intended MICE precision requires the development of analysis tools that can account for any effects (e.g., optical aberrations) which may lead to inaccurate cooling measurements. Non-parametric density estimation techniques, in particular, kernel density estimation (KDE), allow very precise calculations of the muon beam phase-space density and its increase as a result of cooling. In this study, kernel density estimation technique and its application to measuring the reduction in MICE muon beam phase-space volume is investigated.

Topic: Particle accelerators and beam dynamics
Subfield: Aerospace Engineering
Field: Engineering
Domain: Physical Sciences
Dominant frequency bandwidth: an ECG indicator to predict defibrillation success

Some unidentified factors still affect the defibrillation. In the study, Domain frequency bandwidth (DomB) which reflects the spread of frequency content of the surface electrocardiographic (ECG) waveforms was investigated. Lead I, aVF and V/sub 1/ of the ECG from patients who underwent implantable cardioverter defibrillator (ICD) implantation were analyzed independently. VF waveforms of a total of 83 defibrillation trials were analyzed with steps consisting of application of downsampling, linear phase highpass filtering, and power spectral analysis. 3 seconds of VF waveform prior to the defibrillation shock was used. Statistical analysis was done to detect significant difference between successful and unsuccessful groups. The results showed that all DomBs were significantly smaller for the successful group, and the total power have not significantly difference. DomB values are associated with defibrillation outcome. DomB reflects frequency content spread and is associated with the number and size of wavefronts, thus the organization level of the heart.

Topic: Cardiac electrophysiology and arrhythmias
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Model of transfection in human endometrial epithelium cells with hsa-miR-191-5p Model of transfection in human endometrial epithelium cells with hsa-miR-191-5p

Background: Human endometrial cells are important in blastocyst recognition and implantation. We have recently shown that miR-191-5p secreted into culture medium by human embryos cultured and transferred to woman on the fifth day of development was associated with the percentage of pregnant vs. non-pregnant patients. Little is known about the regulation and expression of endometrial miRNAs induced by embryonic miRNAs in endometrial tissue. Therefore, in the present work we explored the viability and transfection of RL95-2 endometrial cell line with agomiR-191. Results: The main results obtained in this study were: First, transfection of RL95-2 cell line with 100nM of lipofectamine in combination with 15, 30, and 60 nM of agomiR-191 for 3, 6 and 24 hours does not affect the viability of RL95-2 cells. Second, we observed expression of miR-191 with 60 pmol of agomiR-191 in a time dependent transfection. Conclusion:: Stimulation of RL95-2 endometrial cell line with lipofectamine does not modify their viability. The transfected RL95-2 endometrial cells showed increased the expression of miR-191.

Topic: Reproductive System and Pregnancy
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
ROB DeSALLE and IAN TATTERSALL: A Natural History of Beer. Yale University Press, New Haven, CT, 2019, 256 pp., ISBN: 978-0300233674 (hardcover), $28.

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Topic: Horticultural and Viticultural Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Role of Protein Kinase C in Normal and Preconditioned Myocardium

것은 PKC를 활성화시키는 기전과 구조에 따른 것이다. 칼슘의존성 PKC 이소체는 활성화되기 위해 칼슘과 diacylglyserol(또는 phorbol ester) 및 phosphatidylserine이 필요한데 반해, 칼슘비의존성인 nPKC는 활성화되기 위해 diacylglycerol과 phosphatidylserine 이 그리고 aPKC는 phosphatidylserine만이 필요하 다. PKC 이소체는 칼슘과 DAG 등의 결합부위가 있는 조절영역(regulatory domain)과 활성부위(active site)가 있는 촉매영역(catalytic domain)으로 이루어 져 있다. PKC가 활성화되려면 세포질에서 세포막이나 핵 등으로 전위(translocation)을 해야 하는데, PKC의 전위는 조절영역에 칼슘이나 DAG 등이 결합한 뒤 촉매영역에서 자가 억제작용을 하고 있던 가성기질 (pseudosubstrate)이 제거되어 활성부위가 노출되면 서 나타난다. PKC의 세포내 작용에 대해서 많은 논쟁이 되고 있 으나 수축단백질과 칼슘의 항상성을 조절하는 것이 주 요 작용점일 것으로 추정되고 있다. 좀 더 구체적으 로 보면, PKC가 troponin I와 troponin T 및 myosin light chain-2를 인산화시켜 심근 수축기능을 조절하 며 Na/Ca exchanger, 세포막 수용체, G-단백질, 미토 콘드리아 단백질, KATP 통로 등에 작용하여 심근내 칼슘의 양을 조절할 것으로 추측된다. Alpha 1adrenergic agonists와 같은 심근 수축 강화제들도 DAG와 inositol phosphate(IP3)에 의한 근소포체의 칼슘 유리를 통하여 PKC를 활성화시킴으로써 수축을 조절한다고 한다. 이와 같이 PKC의 작용기전이 여러 가지 형태로 제시되고 있지만 아직 정확한 기전은 밝혀지지 않은 상태이다.

Topic: Cardiac Ischemia and Reperfusion
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Beam Test of a Large Area n-on-n Silicon Strip Detector with Fast Binary Readout Electronics

A large area (60 mm × 60 mm) n-bulk and n-strip readout silicon strip detector was prototyped for the ATLAS SCT detector. Detector modules of 12 cm strip length were made by butting two detectors. One of the 12 cm modules was irradiated with protons to a fluence of 1.2 × 10 14 p/cm 2 . A beam test was carried out for the non-irradiated and the irradiated detector modules. Efficiency, noise occupancy and performance in the edge regions were analyzed using the beam test data. High efficiency was obtained for the nonirradiated detector and for the irradiated detector for bias voltages down to about half the full depletion voltage. The noise occupancy was &amp;lt;2 × 10 -4 for the 12 cm strips. The measurement of the edge region exhibited a difference in the sensitivity under the bias resistance where no extension of the n + -implant was fabricated. I. INTRODUCTION A large area silicon strip detector (60 mm × 60 mm) with n-strip readout electrodes on an n-bulk substrate was fabricated t...

Topic: Irish and British Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
A channel matching scheme for cross-chain

At present, the cross-chain technology works on becoming a bridge to build trust and transmit the information among chains. However, most of the existing schemes have poor universality, and they also have insufficient protection for the process of information cross-chain transmission. Contraposing the deficiencies above, we propose a channel matching scheme for cross-chain (CMSCC), CMSCC combines the ideas of the relay chain scheme and the channel in Fabric. The relay chain named chain-anchor and relay-chain (CARC) can be connected to other blockchains by multi-blockchain communication and consociation protocol (MBCCP). In CARC, the order peers will match the peers which on different chains and will create the peer matching channel (PMC) among matched peers. So, the information can be transmitted among matched peers. Finally, the experiment verifies that CMSCC enables information to be transmitted among chains through PMC, and CMSCC can also protect the process of information cross-chain transmission by PMC simultaneously.

Topic: Blockchain Technology Applications and Security
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Optimisation of a polymer plant by an embedded hybrid architecture

In this paper a hybrid architecture is developed to optimise set-point changes between different polyethylene brands. This architecture combines two different AI-techniques: a recurrent neural network, which is used to model the polyethylene plant; and a simulated annealing-based optimisation algorithm. Several experiments were performed to demonstrate the capabilities of this hybrid optimisation architecture.

Topic: Advanced Control Systems Optimization
Subfield: Control and Systems Engineering
Field: Engineering
Domain: Physical Sciences
Establishment of an International Registry of Patients with Inherited FXIII Deficiency.

Abstract Inherited factor XIII (FXIII) deficiency is a rare autosomal recessive disorder affecting approximately one out of one to three million people. FXIII deficiency is characterized by a lifelong bleeding tendency, impaired wound healing and spontaneous abortions in females. In 1993, the European Thrombosis Research Organization (ETRO) Working Party on FXIII initiated a Europe-wide questionnaire on inherited FXIII deficiency. Since 2005, the registry has been endorsed by the Factor XIII Subcommittee of the Scientific and Standardization committee (SSC) of the ISTH. The analysis of 104 European patients demonstrated that the most common bleeding symptoms were subcutaneous bleeding (57%) followed by delayed umbilical cord bleeding (56%), muscle hematoma (49%), hemorrhage after surgery (40%), hemarthrosis (36%), and intracerebral bleeding (34%). Prophylactic treatment was initiated in about 70% of all patients. FXIII-B subunit-deficient patients had a milder phenotype than patients with FXIII-A subunit deficiency.The most frequent mutation affecting the F13A gene was a splice site mutation in intron 5 (IVS5-1G&amp;gt;A).This mutation was found in eight (17%) of 46 analyzed families.The haplotype analysis of patients carrying the IVS5-1A allele was consistent with a founder effect. Recently, we created a new FXIII database website (http://www.f13-database.de) with information about FXIII proteins, genes, mutations and polymorphisms. This website also includes a new questionnaire. Information provided by this questionnaire will allow better understanding of the differences of diagnostic and treatment possibilities in various parts of the world, and it will help to understand the impact of reduced FXIII activity in heterozygous relatives and finally, it will generally increase our knowledge on this rare disease. We hope that our initiative to establish a new international FXIII registry will be actively supported by the community involved in caring for FXIII deficient patients.

Topic: Blood properties and coagulation
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Social Justice and the Florida Net Ban Controversy

In a general election in November of 1994 the Florida electorate voted in favor of a referendum limiting marine net fishing in state waters. This amendment to Florida’s constitution represents a resource allocation decision made by the people that is somewhat unprecedented due to its major environmental and human impacts. This paper focuses on the events surrounding what is now commonly known as the Florida “net ban ” issue from a social justice perspective. The two main components of social justice, procedural and distributive, are considered from the viewpoint of commercial fishermen who were directly affected by the net ban controversy. Florida’s commercial fishermen held strong feelings that they were victims of injustice even prior to the net ban. Their comments and behaviors indic ted feelings of procedural injustice and decremental deprivation. After the net ban these pre-existing feelings were intensified and other negative feelings related to inequity may have also developed. The case study also brought attention to features of agency allocation systems and referendum allocation processes that lead to injustices. When responsibility and control over resource allocation is diffuse and the system for passing regulations is subject to lengthy delays, social justice becomes an even more difficult goal to achieve. In both agency allocation processes and referendum processes rules that are designed to enhance procedural justice may not always fulfill this objective in real case situations. Referendum

Topic: Property Rights and Legal Doctrine
Subfield: Law
Field: Social Sciences
Domain: Social Sciences
Influencing Factors to Delivery Selection in Pregnant Women; A Case study in Tehran

Introduction: Considering the side-effects of Cesarean Section, attempts have been made to reduce the rate in different societies. The present study aimed to explore the issue. Particularly, the study focused on what it is that makes Cesarean as the first childbirth option. Methods: This is a descriptive study. The participants of the study were 226 pregnant women referring to a Tehran-located clinic, Iran, during Jan to March 2012that were selected based on purposeful method. Qualitative content analysis was used to analyze the data. A questionnaire consisting of open-ended and demographic-related items was employed to collect data. SPSS (Ver. 16) was used

Topic: Hermeneutics and Narrative Identity
Subfield: Philosophy
Field: Arts and Humanities
Domain: Social Sciences
A Neuroendocrine View of ECT.

A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptide antidepressin-the active principle that relieves both neuroendocrine and behavioral abnormalities.

Topic: Electroconvulsive Therapy Studies
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
BASELINE CHARACTERISTICS OF PATIENTS ENROLLED IN RESOLVE: A PHASE III TRIAL OF DROTRECOGIN ALFA (ACTIVATED) IN PEDIATRIC SEVERE SEPSIS.

Abd-Allah, Shamel; Woodward, Brad; Short, Mary; Wang, Dazhe; Williams, Mark; Lilly, Eli Author Information

Topic: Sepsis Diagnosis and Treatment
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Influence of Movie Success Factors Including Holdbacks in Box Office and VOD Market

Research on movie revenue has been divided into analysis of traditional box-office and studies on online market such as VOD, which have recently emerged. However, the commercial success of a particular movie consists of the box-office revenue and the secondary market performance including VOD. The box-office and VOD markets are connected by holdback, which is the time difference of movie and VOD release, and hence the structured relationship should be considered. In this study, a path analysis model was established and analyzed in order to compare the effects of various factors for the box-office revenue and VOD downloads including the direct and indirect effects of holdback. As a result of an empirical analysis of 237 movies released from November 2018 to October 2019, the factors that mainly influence the box-office success of a movie are marketing and distribution characteristics such as expert ratings and the number of screens, and those for VOD success are creative characteristics such as movie rating and star power. In terms of genre, it was found that drama is advantageous for box-office and action genre for VOD. It was confirmed that holdback tends to directly or indirectly increase box-office revenue and also decrease VOD downloads. The results of this study can have various implications for effective operation strategies and additional copyright contracts including holdbacks for film producers, distributors, and other secondary market stakeholders.

Topic: Cinema and Media Studies
Subfield: Economics and Econometrics
Field: Economics, Econometrics and Finance
Domain: Social Sciences
Early Signs Of Extra Cellular Matrix Remodeling After Immobilization In Old And Young Human Individuals

Skeletal musle disuse has been shown to induce muscle atrophy rapidly in both young and old human individuals (1) as well as extracellular matrix (ECM) remodeling in young individuals (2). However, little is known about the effect of immobilization on ECM remodeling in older individuals. PURPOSE: To study the effect of aging on transcriptional regulatory signaling pathways involved in ECM remodeling with short-term immobilization. METHODS: Myofiber atrophy was induced by application of a knee-brace for a total period of 4 days in young (Y∼20 yrs, n=11) and aged (O∼70 yrs, n=11) individuals. Muscle biopsies of the vastus lateralis (VL) muscle were collected 1 week prior to immobilization and after 24h, 48h and 96h of immobilization. Expression levels of Col1A1, Col3A1, MMP2 and MMP9 mRNAs were determined using real-time RT-PCR and normalized to the Ribosomal Protein Large P0 (RPLP0) mRNA. RESULTS: In both age groups an increase in expression levels of Col1A1, Col3A1, MMP2 and MMP9 mRNA was observed after 24h. In contrast, expression levels of Col1A1 and Col3A1 mRNA were up regulated at 48h and 96h primarily in old individuals and an overall effect of age was observed. The expression level of MMP2 mRNA was not changed from pre at 48h and 96h. The expression level of MMP9 mRNA was up regulated in both age groups at all three time points. CONCLUSIONS: The present data demonstrates early (post 24h) signs of ECM remodeling in both young and old individuals. Moreover, the results point toward an age specific regulation of ECM in response to muscle disuse, with an up regulation of collagen I and III in old only after 48h and 96h of immobilisation. REFERENCES 1) Suetta C et al. Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy. PLoS One. 2012;7(12) 2) Reich KA et al. Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquination and oxidative stress in humans. J Appl Physiol 109: 1404-1415, 2010.

Topic: Muscle Physiology and Disorders
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Stock Market Prediction Using a Hybrid Neuro-fuzzy System

Stock market prediction is an important area of financial forecasting, which is of great interest to stock investors, stock traders and applied researchers. Main issues in developing a fully automated stock market prediction system are: feature extraction from the stock market data, feature selection for highest prediction accuracy, the dimensionality reduction of the selected feature set and the accuracy and robustness of the prediction system. In this paper, an automated decision tree-adaptive neuro-fuzzy hybrid automated stock market prediction system is proposed. The proposed system uses technical analysis (traditionally used by stock traders) for feature extraction and decision tree for feature selection. Dimensionality reduction is carried out using fifteen different dimensionality reduction techniques. The dimensionality reduction technique producing the best prediction accuracy is selected to produce the reduced dataset. The reduced dataset is then applied to the adaptive neuro-fuzzy system for the next-day stock market prediction. The neuro-fuzzy system forms the stock market model adaptively, based on the features present in the reduced dataset. The proposed system is tested on the Bombay Stock Exchange sensitive index (BSE-SENSEX). The results show that the proposed hybrid system produces much higher accuracy when compared to stand-alone decision tree based system and ANFIS based system without feature selection and dimensionality reduction.

Topic: Stock Market Forecasting Methods
Subfield: Management Science and Operations Research
Field: Decision Sciences
Domain: Social Sciences
List of Participants of the Second Cambridge-Delhi-Leiden-Yogyakarta Conference on ‘The Heyday of Colonial Rule: India and Indonesia from the 1830s to 1914’ Leiden, September 24-27, 1985

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Topic: Asian Studies and History
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
A Study of Sense of Self-agency Focused on Cross-correlation and Delay Between Action and Effect in Continuous Operation

Sense of self-agency has been proposed in psychology field, and it is the sense that I am the initiator or source of the action. We discuss it on continuous operation to find out the transition of the sense for a change of delay and cross-correlation that is the degree of noise between an action as an input signal and its effect as an output signal. We conclude that sense of self-agency is affected by both of a cross-correlation and a delay, human gets stronger sense of self-agency when cross-correlation between action and effect is higher, and an acceptable noise and delay to feel enough good operational feeling may be predicted.

Topic: Free Will and Agency
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Chelonus inanitus bracovirus encodes lineage-specific proteins and truncated immune IκB-like factors

Bracoviruses and ichnoviruses are endogenous viruses of parasitic wasps that produce particles containing virulence genes expressed in host tissues and necessary for parasitism success. In the case of bracoviruses the particles are produced by conserved genes of nudiviral origin integrated permanently in the wasp genome, whereas the virulence genes can strikingly differ depending on the wasp lineage. To date most data obtained on bracoviruses concerned species from the braconid subfamily of Microgastrinae. To gain a broader view on the diversity of virulence genes we sequenced the genome packaged in the particles of Chelonus inanitus bracovirus (CiBV) produced by a wasp belonging to a different subfamily: the Cheloninae. These are egg-larval parasitoids, which means that they oviposit into the host egg and the wasp larvae then develop within the larval stages of the host. We found that most of CiBV virulence genes belong to families that are specific to Cheloninae. As other bracoviruses and ichnoviruses however, CiBV encode v-ank genes encoding truncated versions of the immune cactus/IκB factor, which suggests these proteins might play a key role in host–parasite interactions involving domesticated endogenous viruses. We found that the structures of CiBV V-ANKs are different from those previously reported. Phylogenetic analysis supports the hypothesis that they may originate from a cactus/IκB immune gene from the wasp genome acquired by the bracovirus. However, their evolutionary history is different from that shared by other V-ANKs, whose common origin probably reflects horizontal gene transfer events of virus sequences between braconid and ichneumonid wasps.

Topic: Insect symbiosis and bacterial influences
Subfield: Insect Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Sex talk, Indonesian youth and HIV / AIDS.

Cultural taboos inhibit communication about sex, deny and stigmatize deviant sexual practices, and are incorporated into sexual cultures characterized by silence, shame and secrecy. In contemporary Indonesian societies, sex is often infused with negative connotations and referred to as taboo. Considering the threat that an AIDS pandemic poses, HIV/AIDS prevention and treatment represent a critical development issue that requires ongoing commitment from the Indonesian Government and the international donors that provide critical financial support in the health sector. These taboos that inhibit communication about sexuality clearly constrain attempts to challenge negative understandings of sexuality as inherently shameful. However, promotion of reproductive/sexual health and HIV/AIDS prevention is highly contingent upon expanded dialogue about sexuality in both private and public domains. Hence, the author emphasized the need to acknowledge the complex ways in which sexual communication is circumscribed by enduring cultural taboos, and also how sexual dialogue operates to subvert and erode those taboos.

Topic: Adolescent Sexual and Reproductive Health
Subfield: General Health Professions
Field: Health Professions
Domain: Health Sciences