jimnoneill/paper-to-field-training huggingface dataset:
Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review

Heart failure (HF) is a progressive chronic disease that remains a primary cause of death worldwide, affecting over 64 million patients. HF can be caused by cardiomyopathies and congenital cardiac defects with monogenic etiology. The number of genes and monogenic disorders linked to development of cardiac defects is constantly growing and includes inherited metabolic disorders (IMDs). Several IMDs affecting various metabolic pathways have been reported presenting cardiomyopathies and cardiac defects. Considering the pivotal role of sugar metabolism in cardiac tissue, including energy production, nucleic acid synthesis and glycosylation, it is not surprising that an increasing number of IMDs linked to carbohydrate metabolism are described with cardiac manifestations. In this systematic review, we offer a comprehensive overview of IMDs linked to carbohydrate metabolism presenting that present with cardiomyopathies, arrhythmogenic disorders and/or structural cardiac defects. We identified 58 IMDs presenting with cardiac complications: 3 defects of sugar/sugar-linked transporters (GLUT3, GLUT10, THTR1); 2 disorders of the pentose phosphate pathway (G6PDH, TALDO); 9 diseases of glycogen metabolism (GAA, GBE1, GDE, GYG1, GYS1, LAMP2, RBCK1, PRKAG2, G6PT1); 29 congenital disorders of glycosylation (ALG3, ALG6, ALG9, ALG12, ATP6V1A, ATP6V1E1, B3GALTL, B3GAT3, COG1, COG7, DOLK, DPM3, FKRP, FKTN, GMPPB, MPDU1, NPL, PGM1, PIGA, PIGL, PIGN, PIGO, PIGT, PIGV, PMM2, POMT1, POMT2, SRD5A3, XYLT2); 15 carbohydrate-linked lysosomal storage diseases (CTSA, GBA1, GLA, GLB1, HEXB, IDUA, IDS, SGSH, NAGLU, HGSNAT, GNS, GALNS, ARSB, GUSB, ARSK). With this systematic review we aim to raise awareness about the cardiac presentations in carbohydrate-linked IMDs and draw attention to carbohydrate-linked pathogenic mechanisms that may underlie cardiac complications.

Topic: Metabolism and Genetic Disorders
Subfield: Clinical Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Techniques and Protocols for Acquisition and Display of Contrast-Enhanced CT Angiography

Contrast-enhanced computed tomography (CT) studies of the coronary arteries were performed first to visualize the vessel lumen and to achieve an angiographic-like presentation of the coronary arteries in combination with 3D postprocessing methods (). Because short exposure times are essential for coronary CT angiography (CTA), investigations initially were performed with electron beam CT (EBCT) scanners. These dedicated cardiac CT scanners were originally designed to measure myocardial perfusion (). For morphological assessment of cardiac structures, a restrictive scan protocol with EBCT allows for 100-ms exposure time, 3-mm slice thickness, and 130-kVp, 630-mA electron-gun power. The acquisition of every single slice is triggered prospectively by the electrocardiogram (ECG) signal at the end systolic phase of the cardiac cycle.

Topic: Cardiac Imaging and Diagnostics
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Clinical significance of postmastectomy radiotherapy to chest wall and armpit in breast cancer

Objective To evaluate chinical significance of postmastectomy radiotherapy to chest well and armpit in breast cancer.Methods Complete data was obtained by visiting 146 patients including Ⅱ A period 46 cases,Ⅱ b period 53 cases,Ⅲ A period 39 cases,Ⅲ b period 8 cases.Among these patients,46 received chest wall irradiation(chest-wall-group),50 received top area of clavicle and the interior area of breast irradiation(2-fields-group),50 received top area of clavicle,interior area of breast and armpit(3-fields-group).Each fields use a does of between 50-55Gy,accomplished between 5.0～5.6 weeks.Results The 1-year,2-year and 3-year regional control rates were 98.0%,95.5%,95.5% in all patients for chest-wall-group;87.0%,82.4%,79.4%for two-fields-group;91.5%,84.2%,80.8% for three-fields-group.Clest-wall-group and two-fields-group χ2=4.524,P0.05.Chest-wall-group and 3-fields-group,P=0.056.Chest wall recurrence rates were 2.2% for the chest-wall irradiated group,13%,P0.05 for the chest-wall-unirradiated group.(2-fields-group and 3-fields-group).Armpit recurrence rates were 8% and 2%,P0.05.Dropsy rates in arms were 14%,38%,P0.01 for above two groups.The 1-year,3-year and 5-year survival rates were 97.8%,85.1%,80.3% and 95.9%,83.4%,71.1% and 93.8%,82.9,65.7% in all patients for three groups.χ2=0.135 for the chest-wall-group,χ2=1.496 for both the two and the three and P0.05 is for all of them.On distant metastasis of the carcinoma,it is 10.8% with χ2=0.23,8% and 10% with χ2=0.019 for 1-group,2-group and 3-group;P0.05 for both Group 2 and Group 3.Conclusion By chest wall irradiation,regional controlling rates can be greatly improved and locoregional recurrence is reduced.However,survival rate is not improved.

Topic: Cancer Diagnosis and Treatment
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Corpus Linguistic Exploration of Modern Proverb Use and Proverb Patterns

In my talk, I present an empirical approach to detecting and describing proverbs as frozen sentences with specific functions in current language use.We have developed this approach in the EU project 'SprichWort' (based on the German Reference Corpus).The first chapter illustrates selected aspects of our complex, iterative procedure to validate proverb candidates.Based on our corpus-driven lexpan methodology of slot analysis I then discuss semantic restrictions of proverb patterns.Furthermore, I show different degrees of proverb quality ranging from genuine proverbs to non-proverb realizations of the same abstract pattern.On the one hand, the corpus validation reveals that proverbs are definitely perceived and used as relatively fixed entities and often as sentences.On the other hand, proverbs are not only interpreted as an interesting unique phenomenon but also as part of the whole lexicon, embedded in networks of different lexical items.

Topic: Language, Metaphor, and Cognition
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Effects of perceived diversity on perceived organizational performance

Purpose The purpose of this paper is to investigate the association between constructs of employee perception of diversity (EPD) and perceived organizational performance (POP) through components of organizational justice over different hierarchal levels and also across the private and public healthcare sector organizations. Additionally, this study also examines whether employees from diverse backgrounds vary in their perceptions regarding diversity in healthcare sector of Pakistan. Design/methodology/approach Data were collected from primary sources, that is medical, paramedical and administrative staff (different designations) of both public and private hospitals for analyzing the results. The overall population consisted of 250 respondents and the hypotheses were tested using two-way ANOVA and CAUSALMED procedures. The data were collected during the course of three months in different time slots from 9 a.m. to 9 p.m. Statistical Analysis Software was used to analyze the data. Findings Findings indicate that regardless of their gender or categories, employees recognize diversity positively, but their responses have significant difference over the hierarchal levels. Furthermore, it is found that EPD is positively linked to the POP, and the relationship gets stronger in the presence of perceived organizational justice (POJ). Research limitations/implications The study was confined to the healthcare sector, so further studies can be conducted in other sectors. The present study checked the impact of POJ, but other important reasonable factors that can intervene in the relationship between perceived diversity and POP can be studied, such as organizational commitment. Practical implications First of all, it is dispensable for the organizations to ensure the positive perception of these initiatives from employees to implement the diversity programs. Second, the management must ensure the presence of all groups of employees to get the right responses for the diversity management initiatives. Third, the healthcare industry of Pakistan needs to be assessed in the context of current study and diversity initiatives should be taken in hiring and retention of the employees. Originality/value The presence of employees of healthcare industry across the sector over hierarchal levels will absolutely add value to the existing knowledge on diversity, diversity management, management theory and practice.

Topic: Gender Diversity and Inequality
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Towers of hanoi problem with arbitrary<i>k</i>≧3 pages

The Towers of Hanoi problem with arbitrary k≧3pegs is an extension of the standard one. In this paper we present a nice recursive algorithm for this extended problem and then analyze its complexity. The analysis is based on a group of integer sequences which are closely related to the complexity of the algorithm and which are also independently significant because they possess some elegant combinatorial properties.

Topic: Algorithms and Data Compression
Subfield: Artificial Intelligence
Field: Computer Science
Domain: Physical Sciences
"A Phenomenological Study on the Telecommuting Experience of Office Workers in a Pandemic Situation"

연구 목적: 이 연구는 팬데믹 상황에서 직장인의 재택근무 경험을 알아보기 위해 수행되었다. 연구 방법: 연구방법은 개인의 주관적 경험을 잘 드러낼 수 있는 Giorgi의 현상학적 연구 방법에 따라 분석하였다. 연구 내용: 이 논문의 연구내용은 6명의 연구참여자들을 모집하여 팬데믹 이전과 이후의 근무경험을 비교하여 면담하였으며, 개방적이고 반구조화된 질문지를 구성하여 진행하였다. 결론 및 제언: 분석결과 ‘출퇴근 방식’, ‘동료나 상사와의 의사소통’, ‘업무에 대한 만족’, ‘일과 자기성장’의 4개의 범주와 15개의 주제묶음, 64개의 주제가 도출되었다. 본 연구를 통해 팬데믹 상황에서 비자발적으로 시작된 직장인들의 재택근무 경험을 출퇴근 방식과 비교해서 그 차이점을 살펴볼 수 있었다. 나아가 포스트 코로나 시대에 변화할 근무환경에 대한 시사점이 무엇인지에 대해 살펴보았다는 점에 본 연구의 의의를 둘 수 있다.

Topic: Korean Urban and Social Studies
Subfield: Management, Monitoring, Policy and Law
Field: Environmental Science
Domain: Physical Sciences
Abstract PCCLB-50: PREDICTIVE VALUE OF AN EARLY AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAM FOR NEUROLOGIC OUTCOME IN PRETERM INFANTS

Aims & Objectives: The aim of this study were to assess characteristics of aEEG in preterm infants with adverse neurologic outcome such as intraventricular hemorrhage, periventricular leukomalacia or death and to evaluate whether aEEG in the early days of life has predictive value of short-term neurologic outcome in preterm infants. Methods All preterm infants born at less than 32 weeks of gestational age or less than 1500 gm of birth weight who admitted the neonatal intensive care unit of Pusan National University Hospital between December 2016 and November 2017 were included. aEEG were monitored at 12~14 hours (day 1), 46~48 hours (day 2), 70~72 hours (day 3), and 1 week of life (day 7). The aEEG recordings were analyzed using criteria described by Burdjalov et al. Brain ultrasonography was performed before 3 days of life first. Based on brain ultrasonography, infants were divided into two groups, which are favorable group and adverse group respectively. Results Forty four infants were enrolled. A total of 176 aEEG tracing were analyzed. Twenty seven infants and 17 infants were identified in favorable group and adverse group respectively. Infants in favorable group showed high scores in almost all components. Especially, scores of all components were decreased significantly at day 2 in adverse group than favorable group. Less than 3 of total score has predictive value of 70.6% of sensitivity and 81.5% of specificity for adverse outcome. Conclusions We demonstrated that preterm infants with lower score of aEEG especially during the second day of life than first day of life.

Topic: Neonatal and fetal brain pathology
Subfield: Pediatrics, Perinatology and Child Health
Field: Medicine
Domain: Health Sciences
How does self-concept clarity influence happiness in social settings? The role of strangers versus friends

Self-concept clarity (SCC), defined as the extent to which the content of an individual’s self-beliefs is clearly and confidently defined and internally consistent, influences experiences in social relationships. This paper extends the previous literature on SCC by proposing and demonstrating that high-SCC individuals anticipate and experience more happiness than low-SCC individuals when they share a social setting with friends and anticipate and experience less happiness than low-SCC individuals when they share a social setting with strangers and that this is because of perceived interpersonal distance. A series of four studies, including both online studies and a field study, support these predictions. Alternative explanations of self-esteem and self-efficacy are also ruled out. The findings yield both theoretical contributions and practical implications.

Topic: Behavioral Health and Interventions
Subfield: Applied Psychology
Field: Psychology
Domain: Social Sciences
Joint Construction Stage of Genre-Based Approach to Enhance Students’ Writing Skills

The studies on the effectiveness of using genre-based approach to improve students’ L2 writing skill in University setting have been positive, however, there are only few studies that apply this approach in senior high school setting. The purpose of this study is to examine the effectiveness of joint construction stage of genre-based approach to improve students’ English as a Foreign Language (EFL) writing skills for senior high school students in Indonesia. The study was conducted using quasi experimental design with one research group and one control group. The participants of this study were two classes. The experimental class was given the joint construction stage of genre-based approach while the control group was given the genre-based approach without joint construction. The number of subjects was 30 in a class. The data was collected by using a pretest and a posttest. Statistical Package for Social sciences (SPSS) was used for analyzing the tabulated data. The result shows that there was a significance improvement between pretest and posttest in both control and experimental group. This means the methods are effective to enhance the students’ writing skills both in experimental and control group. The result of this study is expected to contribute a solution for improving L2 students’ writing skill.

Topic: Educational Methods and Media Use
Subfield: Information Systems
Field: Computer Science
Domain: Physical Sciences
Postdischarge Impact of C-L Psychiatry Treatment in Obstetrical Inpatients

Purpose . Twenty-eight women, referred to C-L Psychiatry during their obstetrical inpatient stay were interviewed six months post-discharge to determine how they experienced the consultation process, whether they recollected and adhered to treatment recommendations, and whether they developed or had a recurrence of mental health problems post-discharge. Method . Semi-structured telephone interviews were conducted by a psychologist who had not been involved with patient care. Results . There was strong congruence between reason for referral as stated in psychiatric consult notes and participants' recollections and strong congruence and compliance regarding treatment recommendations. Sixty-four percent of women had concerns regarding mood post-discharge, of whom 66% sought professional help within six months. Participants' recommendations for improving the effectiveness of the C-L service to obstetrical inpatients pertained mainly to sensitivity to patients' feelings, consistency of message and personnel, and post-discharge follow-up. Conclusions . Obstetrical patients had good recollection of their experience of C-L psychiatry, and post-discharge compliance with treatment recommendations was high. A post-discharge telephone call might further enhance treatment compliance and encourage women who are struggling with mood difficulties to seek help. Contact between C-L psychiatry and patients' primary care physician may also enhance care post-discharge.

Topic: Maternal Mental Health During Pregnancy and Postpartum
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
Inside the head of a cybertype – three-dimensional reconstruction of the head muscles of Ommatoiulus avatar (Diplopoda: Juliformia: Julidae) reveals insights into the feeding movements of Juliformia

Abstract The origin and diversification of the arthropod head is one of the major topics in the field of evolutionary morphology of Arthropoda. Among the major arthropod groups, Myriapoda and, more precisely Diplopoda, are generally poorly studied regarding their head anatomy. However, this group is of pivotal importance to understand the evolutionary functional morphology of the arthropod head. In this study, we investigate the complete musculoskeletal system of the diplopod head with a detailed description of the cephalic anatomy of the recently described species Ommatoiulus avatar. The comparison of our data with the literature on the few other species available show that the morphology of the musculoskeletal system within Juliformia, a subgroup of the Diplopoda, is relatively conservative. Using video recordings of the feeding movements in addition to the anatomical data, we revise the mechanism of the mandibular movements in Juliformia. There was a controversy whether mandibular abduction is an active process, facilitated by contraction of an abductor muscle, or if it is a passive process, mediated by tentorial and gnathochilarial movements not involving a direct abduction by muscular contraction. We show that mandibular abduction in Ommatoiulus is an active movement involving the contraction of an abductor muscle. This is similar to the mandibular abduction in other arthropod groups.

Topic: Insect and Arachnid Ecology and Behavior
Subfield: Genetics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Supercritical thermodynamcis of sulfur and nitrogen species. Quarterly progress report, April 1, 1992--June 30, 1992

Significant opportunity exists for the application of supercritical fluid (SCF) technology to coal processing, both for pretreatment of high sulfur coals, as well as liquefaction and treatment of coal liquids. Supercritical fluids are attractive solvents for a variety of coal processing applications because of their unusual solvating and mass transfer properties. Solubility studies have been carried out for a number of model coal and coal liquid compounds, primarily in pure supercritical fluids. We are extending this database of model coal compound equilibria using modern techniques that have the advantage of being much more rapid than traditional techniques. Cosolvent effects on solubility are being investigated over a variety of solvent properties. In addition, specific molecular interactions are being investigated through spectroscopic techniques. The resulting data are being used to develop a chemical-physical equation of state (EOS) model of SCF solution with meaningful parameters. The equation of state will be used to predict solubility behavior, which will permit the design and tailoring of SCF cosolvent systems for specific coal processing applications.

Topic: Phase Equilibria and Thermodynamics
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Design and Application of Single Chip Microcomputer in SCR Light Regulation Circuit

The aim of this article is to achieve the application of single chip microcomputer in SCR light regulation circuit. Its control part is simplified by analyzing the principle of SCR light regulation circuit. According to control function, the design scheme that let the single chip microcomputer bring about a good control function in SCR light regulation circuit is proposed. The experiment results demonstrate this design is practicable. The light regulation function could be realized by the single chip microcomputer.

Topic: Photonic and Optical Devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Effect of Ag and Zr solutes on dislocation emission from the Σ11(332)[110] symmetric tilt grain boundary in fcc Cu

Addition of solutes is commonly used to stabilize nanocrystalline materials against grain growth. However, segregating at grain boundaries, these solutes also affect the process of dislocation nucleation from grain boundaries under applied stress. Using atomistic simulations we demonstrate that the effect of solutes on the dislocation nucleation strongly depends on the distribution of solutes at the grain boundary, which can vary dramatically depending on the solute type. In particular, our results indicate that the solutes with a smaller size mismatch can be more effective in suppressing dislocation emission from grain boundaries. Bearing in mind that dislocation slip originating from grain boundaries or their triple junctions is the dominant mechanism of plastic deformation when grain sizes are reduced to the nanoscale, we emphasize the importance of the search for the optimal solute additions, which would stabilize the nanocrystalline material against grain growth and, at the same time, effectively suppress the dislocation nucleation from the grain boundaries.

Topic: Microstructure and mechanical properties
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Soothing effect of virgin coriander seed oil on sensitive skin

Sensitive skin is a common condition that concerns many people in the world. This syndrome is defined by the occurrence of unpleasant sensations such as stinging and burning in response to stimuli that normally should not provoke such sensations. The main hypothesis attributed to the occurrence of sensitive skin is the disruption of the epidermal barrier and a greater penetration of substances such as irritants. In keratinocytes, the NF-κB pathway, which plays an important role in orchestrating inflammatory responses, is then activated. Regulation of this activation is a key issue to control inflammation. Due to the wide variety of sensory symptoms, neurosensory dysfunction also represents a mechanism to be considered. Some of the cutaneous nerve endings express TRPA1, a sensor of skin barrier insult, which is involved in a variety of physiological or cellular processes including nociception, itch and neurogenic inflammation. Regulation of such sensor activation is also an issue to consider to control neurosensory dysfunction. Coriander seed oil is a 100% virgin oil of coriander seeds and boasts a unique composition of fatty acids. The soothing effect of coriander seed oil on sensitive skins was investigated by studying its capacity to regulate NF-κB and TRPA1 activation. Coriander seed oil allowed the regulation of NF-κB activation induced by TNF-α in an in vitro model of inflammation in keratinocytes. It also regulated the activation of TRPA1 induced by allyl isothiocyanate in an in vitro model of keratinocytes-neurons co-culture. These results are in favor of a soothing effect of coriander seed oil.

Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences