jimnoneill/paper-to-field-training huggingface dataset:
Feature extraction from event logs for predictive monitoring of business processes

In this master’s thesis, we investigate feature extraction techniques for event log traces. We provide an overview over the field of predictive monitoring and analyze existing trace profiles proposed in the literature. Based on this, we apply the results obtained in recent research on process discovery to find meaningful abstractions over related subsequences of events.We assess different feature sets by evaluating their predictive power in a supervised classification setting as well as a semi-supervised outlier detection setting. For this purpose, we use two datasets from public administration, describing complex processes in EU agricultural subsidy management. Our particular goal in this domain is to predict negative outcomes, for instance, additional work due to legal claims or corrections necessary after initial payment decisions.

Topic: Business Process Modeling and Analysis
Subfield: Management Information Systems
Field: Business, Management and Accounting
Domain: Social Sciences
Least-squares Spline Regression with Block-diagonal Variance Matrices

Journal Article Least-squares Spline Regression with Block-diagonal Variance Matrices Get access M. G. Cox, M. G. Cox Division of Information Technology and Computing, National Physical LaboratoryTeddington, Middlesex TW11 0LW Search for other works by this author on: Oxford Academic Google Scholar P. E. MANNEBACK P. E. MANNEBACK Department of Mathematics, Facultés UniversitairesNamur, Belgium Search for other works by this author on: Oxford Academic Google Scholar IMA Journal of Numerical Analysis, Volume 5, Issue 3, July 1985, Pages 275–286, https://doi.org/10.1093/imanum/5.3.275 Published: 01 July 1985 Article history Received: 09 July 1984 Published: 01 July 1985

Topic: Spectroscopy and Chemometric Analyses
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model

Alzheimer's disease is a complex neurodegenerative disorder that drastically impairs intellectual and emotional functioning in afflicted individuals. The disease is characterized pathologically by a temporal and spatial progression of amyloid-beta (Aβ) deposition, neurofibrillary tangle formation, and synaptic degeneration. Inflammatory mediators have long been proposed as being integral for initiating and/or propagating AD-associated pathologic processes within the brain. To this end, we assessed the expression of proinflammatory molecules in the recently described triple transgenic mouse model (3xTg-AD), which exhibits Aβ deposition, neurofibrillary tangle formation, and synaptic dysfunction with regional specificity similar to human AD. We observed significant up-regulation of the pro-inflammatory cytokine, TNF-α, specifically within one of the earliest affected brain regions in AD, the entorhinal cortex, prior to the onset of overt amyloid pathology. Moreover, the 3xTg-AD entorhinal cortex, unlike the hippocampus, harbored an increased number of microglia/macrophages as determined by quantification of F4/80-positive cells, further implicating the entorhinal cortex in inflammatory processes at early stages of the disease. A recombinant adeno-associated virus (rAAV) vector expressing TNF-α to create a sustained focal inflammatory response was stereotactically delivered to 3xTg-AD mice prior to the appearance of pathological signatures. In ongoing studies, we have observed significant alterations in downstream TNF-α related signaling molecule expression in transduced brain tissues and concomitant modulation of memory/learning behaviors. This integrated biochemical, immunohistochemical, and behavioral approach will provide major insights into the involvement of TNF-α mediated inflammation in the temporal and spatial progression of early AD pathogenic events and carries the potential to reveal new therapeutic targets. Supported by NIH F31NS049995 to MCJ, NIH R01AG020204 to HJF, and NIH R01AG023593 to WJB.

Topic: Neuroinflammation and Neurodegeneration Mechanisms
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
What's so Sectarian about Sectarian Politics? Identity Politics and Authoritarianism in a New Middle East

Abstract Shia/Sunni sectarianism figures prominently in post‐Arab uprising claims that the Middle East is witnessing a darker kind of authoritarianism drawing on exclusionary and xenophobic forms of identity politics. This article explores whether sectarianism per se is associated with a distinct form of identity politics or if authoritarian techniques involving the use of the ‘sectarian card’ should be subsumed under a broader category of authoritarian identity politics involving the inclusion or exclusion of social groups based on identity and implemented with varying degrees of repression. The article shows how Brubaker's analytical distinction between a ‘diacritical’ and ‘normative ordering power’ understanding of religious identities gives rise to different expectations in regard to whether sectarianism leads to different and more violent forms of repression than other forms of identity politics. Against this background, the article compares authoritarian identity politics in Bahrain, Kuwait, Jordan, and Egypt, which all differ from each other both in terms of the importance of a Shia/Sunni distinction compared to other identity cleavages, and also as regards the intensity and level of the regime's response to the Arab uprisings. From this comparison five general lessons about sectarianism and authoritarian identity politics can be drawn.

Topic: Jewish and Middle Eastern Studies
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
The Cambridge Companion to the Harlem Renaissance

The Harlem Renaissance (1918–1937) was the most influential single movement in African American literary history. Its key figures include W. E. B. Du Bois, Nella Larsen, Zora Neale Hurston, Claude McKay, and Langston Hughes. The movement laid the groundwork for all later African American literature, and had an enormous impact on later black literature world-wide. With chapters by a wide range of well-known scholars, this 2007 Companion is an authoritative and engaging guide to the movement. It first discusses the historical contexts of the Harlem Renaissance, both national and international; then presents original discussions of a wide array of authors and texts; and finally treats the reputation of the movement in later years. Giving full play to the disagreements and differences that energized the renaissance, this Companion presents a set of new readings encouraging further exploration of this dynamic field.

Topic: American and British Literature Analysis
Subfield: Literature and Literary Theory
Field: Arts and Humanities
Domain: Social Sciences
CLINICAL OBSERVATIONS ON THE USE OF TERRAMYCIN HYDROCHLORIDE

The discovery of a new antibiotic called terramycin was reported recently by Finlay and associates.<sup>1</sup>This drug is produced by Streptomyces rimosus, a new actinomycete isolated from a soil sample, and is described as a crystalline amphoteric substance which can form either salts with acids (terramycin hydrochloride) or salts with bases (the sodium salt of terramycin). Currently, 1 microgram of the amphoteric compound has been defined as containing 1 microgram of activity, and the activity of the salts are stated in terms of the equivalent weight of pure terramycin. In vitro the antibiotic has a wide activity against many species of bacteria, both gram positive and gram negative.<sup>2</sup>The purpose of this preliminary study is to report the clinical results observed after the oral administration of terramycin hydrochloride<sup>3</sup>in patients with various infections, which are described in the accompanying table. From the tabulation it will be noted

Topic: Synthesis of β-Lactam Compounds
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
SYNTHETIC LETHALITY AND SEMI-LETHALITY AMONG FUNCTIONALLY RELATED MUTANTS OF <i>DROSOPHILA MELANOGASTER</i>

sex-linked mutant deep orange (dor) of Drosophila melanogaster is Tzonsible for a peculiar type of female sterility: mutant females produce no progeny when crossed to mutant males but yield some offspring (heterozygous daughters) when mated to wild-type males (MERRELL 1947). The effects of this mutant on embryonic development have been extensively studied by COUNCE (1956a) and more recently by HILDRETH and LUCCHESI (1967). In addition to the sterility phene, dor alters the pigmentation of the eyes (which are orange in color) and confers an abnormal spectrum of relative pteridine concentrations. An unusual characteristic of dor is that isoxanthopterin appears to be accumulated by mutant females (COUNCE 1957). During the course of preliminary investigations into the biochemical basis of dor female-sterility, art attempt was made to prevent the accumulation of isoxanthopterin in mutant females by genetic means. This resulted in the discovery of a highly specific synthetic lethal system involving dor and a non-allelic third chromosome mutant, rosy (ry) . The dor-ry system is similar to three other synthetic lethal systems, previously described in D. melanogaster: purpleoid (pd) and Purpleoider (Pdr) (BRIDGES 1922; as cited in BRIDGES and BREHME 1944) ; prune (pn) and Prune-killer (K-pn) ( STURTEVANT 1956) ; and Henna-recessiue-3 (Hnr3) and rosy (ry6) (TAIRA 1960; GOLDBERG, SCHALET and CHOVNICK 1962). A search was undertaken for the purpose of uncovering additional interactions among some of the mutants mentioned above. Since six of the latter affect eye color and/or pteridine levels, a number of other eye color mutants were tested. In addition, the female sterile mutant fused (fu) , similar in many respects to dor (although allowing lethal embryos to develop further than dor embryos (COUNCE 195613) ). was used in <some crosses. The results of these investigations are presented in this paper.

Topic: Insect Resistance and Genetics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Abstract 404: Proinflammatory cytokine IL-1β stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis

Abstract Recent studies have suggested that mast cells have critical roles in angiogenesis. However, the detailed mechanism by which mast cells contribute to angiogenesis is not yet clearly understood, especially in response to proinflammatory cytokines. In this study, we showed that the proinflammatory cytokine IL-1β induces the synthesis of IL-8, a potent angiogenic factor, in human mast cells via the leukotriene B4 receptor (BLT)2. We also characterized the BLT2 downstream signaling pathway and determined that BLT2-mediated IL-8 synthesis involves the upregulation of Nox1, a member of the NADPH oxidase family, Nox1-dependent reactive oxygen species generation and the subsequent activation of the redox-sensitive transcription factor NF-κB. For instance, knockdown of BLT2 and Nox1 with specific small interfering RNA, treatment with a specific BLT2 antagonist, LY255283, or treatment with a potential Nox inhibitor, diphenylene iodonium, suppressed IL-1β-induced IL-8 synthesis. We found that the conditioned media collected from IL-1β-treated human mast cell line HMC-1 had significantly enhanced angiogenic activity that could be dramatically attenuated by either small interfering RNA knockdown of BLT2 or treatment with neutralizing Ab to IL-8. Finally, the experiments were repeated using human primary cord blood-derived mast cells, and the results were clearly reproduced. Taken together, our results suggest that BLT2-Nox1-reactive oxygen species-dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1β, thus contributing to angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 404. doi:10.1158/1538-7445.AM2011-404

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
A CASE OF NEUROLEPTIC MALIGNANT SYNDROME: A NEUROLOGIC EMERGENCY DUE TO PSYCHOTROPIC DRUGS

Objectives:To present a scientific poster discussing one case of Neuroleptic Malignant Syndrome (NMS) in an outpatient with Residual Schizophrenia (RS).Background:NMS is an infrequent yet life threatening condition characterized by delirium, muscular rigidity, fever and autonomic nervous system dysregulation. Generally, itu2019s caused by dopamine receptor-antagonist therapeutic agents or in the set of rapid withdrawal of dopaminergic medications.Materials and Methods:A clinical case is presented. A bibliographic search was conducted using the search engine Pubmedu00ae and the keywords: u201cNeuroleptic Malignant Syndromeu201d.Results and Conclusions:A 37 years old man with a diagnosis of RS on typical and atypical anti-psychotics, was admitted in the emergency room with impaired mental status and behavioral changes. 5 days prior to presentation, he had been exposed to an overdose with anti-psychotics. No clinical evidence of alcohol and drug abuse. A battery of biochemical exams was performed and Central Nervous System infection was ruled out. Due to fast setting of the disorder, fever, muscle rigidity and altered mental status, it was assumed to be a NMS in the context of psychotropic toxicity.When early recognized, NMS is usually not fatal and the majority of patients will recover completely between 2 to 14 days. Treatment is individualized and based on the clinical presentation. The first step implies cessation of the offending psychotropic agent. In most cases, besides hyperthermia management, conservative treatment including aggressive hydration and metabolic abnormalities correction may be needed. Recurrence do occur, hence the importance of precautious reintroduction of antipsychotic treatment.

Topic: Psychosomatic Disorders and Their Treatments
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
[Overview of HIV infections in pediatric population].

A general overview of HIV infection/AIDS in the pediatric population, in Mexico, is provided. The principal categories of transmission in our country are: 45.5% perinatal, 44.0% following transfusion for hemophilia or for other reasons, and less frequently sexual transmission. In the United States and Europe, similar patterns are seen with perinatal transmission being the most important route, at higher percentages than ours. The number of cases of HIV infection in children continues to grow worldwide, primarily reflecting the problem in the adult population.

Topic: HIV/AIDS oral health manifestations
Subfield: Public Health, Environmental and Occupational Health
Field: Medicine
Domain: Health Sciences
<scp>CBF1</scp> is an underestimated plant regulatory transcription factor

Abstract CBF1 transcription factors have been extensively utilized for their remarkable contribution to stress resistance that helps plants to cope with complex abiotic stresses. However, their regulation of plant type and other traits is often neglected. We overexpressed the Ammopiptanthus mongolicus CBF1 gene in cotton. Three transgenic lines, L28, L30, and L41, with high expression levels were successfully obtained. Subsequently, we comprehensively examined multiple cotton phenotypes, including plant height, overall morphology, leaf shape, leaf colour, and leaf thickness. Additionally, we analysed hormone levels, yield, and fibre quality. Through comparative analysis, we found that the overexpressed plants had strong root structure, dwarf and compact architecture, more serrated leaf edges, thick leaf tissues, and darker leaf colour compared to wild cotton. Moreover, there was a significant decrease in IAA and GA3. The overexpressing plants displayed many trait alterations, all of which were regulated by AmCBF1. The study of aboveground plant morphology in crops is essential for understanding crop growth and yield. Significantly, although CBF1 plays a prominent role in mediating stress resistance, its importance in influencing plant architecture and other traits has been somewhat overlooked. Consequently, exploring the diverse roles of CBF1 in plant development will be crucial in future research.

Topic: Plant Molecular Biology Research
Subfield: Plant Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Evolution, Adaptation, and Supercoiling

Geometrical and, to some extent, physical and informational properties of covalently closed DNA molecules (or molecules that can be ideally viewed as closed) are determined by their connectivity, i.e., the number of times one strand of DNA is topologically linked to another. Any link that cannot be

Topic: DNA and Nucleic Acid Chemistry
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
3D Extension of the multi parametric acquisition Multi-Phase balanced non-Steady State Free Precession

We propose a 3D extension of the novel MP-b-nSSFP sequence, which interleaves RF pulse types for Multiparametric mapping from the transient response. Comparing selective versus non-selective refocusing pulses we observe lower bias with non-selective pulses, despite modelling the spatially varying effect of the pulses in the fitting process. Phantom and in-vivo comparison to QRAPTEST (MAGIC) are performed.

Topic: Electron Spin Resonance Studies
Subfield: Biophysics
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Long non-coding RNA DANCR upregulates IGF2 expression and promotes ovarian cancer progression.

In this study, we revealed that DANCR could enhance the proliferation, migration and invasion capacities of ovarian cancer cells by upregulating IGF2. Our findings might offer a potential therapeutic choice for patients with ovarian cancer.

Topic: Cancer-related molecular mechanisms research
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
A New Method to Better Measure and Interpret Non-Verbal Communication in Patient-Therapist Interactions

<title>Abstract</title> Objective(s): To develop a novel method of examining facial affects in psychotherapeutic settings and interpreting the subliminal microexpressions and emotions they represent.Results: Therapy sessions are videotaped, and verbal content is evaluated with computer assistance from ATLAS.ti. Visual content is screened for facial action units/micro-expressions using the Facial Action Coding System (FACS) and reevaluated using the Emotional Facial Action Coding System (EmFACS) in order to discern the underlying emotions. Working Alliance Inventory scores are compiled to assess their impact on the quality of the therapeutic relationship. Reliability of facial action unit coding is ensured by a training course and an independently evaluated standardized test at Innsbruck University. Interrater reliability was excellent (Cohen’s κ &gt; 0.80). Application of this method on a small study population to measure non-verbal communication and affects demonstrated its feasibility and usability. We believe this methodology to be widely implementable. Its application in psychotherapy may provide greater insights in investigations into important aspects of therapeutic interaction (e.g. verbal/non-verbal communication between clinicians and patients in psychiatric contexts, quality of psychotherapeutic relationships, etc.), and may be exploitable in clinical psychotherapeutic settings to better understand mechanisms of change in therapy.

Topic: Psychotherapy Techniques and Applications
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Effect Of Alternate Protein Source Soybean Meal And Sesame Oil Cake On Growth Performance And Body Composition Of Fresh Water Fish Cirrhinus Mrigala

A 60 days experiment was carried out under laboratory conditions where Cirrhinus mrigala, mrigal fries (0.55±1g) were maintained in glass aquaria filled with fresh water. Three main protein sources fish meal (protein from animal source), sesame oil cake and soybean meal (protein from plant source) were used in diets. Further, soybean was taken in two forms raw and processed. Eight diets were formulated with equal proportion of raw soybean in 1-4 diets, and hydrothermically processed soybean in 5-8 diets following inclusion levels (65, 130, 195, 260 g kg-1 diet). While sesame oil cake was incorporated in all diets in equal amount. 100% fish meal based diet was used as control in this experiment. Fishes were randomly distributed @ 15 fish per aquarium with duplicates for each dietary treatment. Results showed that where mrigala fry fed on processed soybean based diet Growth % gain and SGR % significantly (P &lt; 0.02) increased. Protein efficiency ratio recorded maximum in diet 5. Maximum values were increase in these parameters were observed in diet 6th, where fish meal and processed soybean meal were applied in equal amount in diet in comparison to fish fed on control diet. Feed intake was also declined with the increase in inclusion level of soybean meal, but the feed conversion ratio (FCR) and protein efficiency ratio (PER) maximum in diet 3 and reference were followed by other diets. Our results suggest that soybean meal can be a suitable source without compromising weight gain or feed efficiency in fry of C. mrigala

Topic: Aquaculture Nutrition and Growth
Subfield: Aquatic Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Less p53 for life

![Graphic][1] 

Female (left) and male (right) flies lacking (black lines) neuronal p53 live significantly longer.

HELFAND/ELSEVIERNew findings from Johannes Bauer, Stephen Helfand (Brown University, Providence, RI), and colleagues show that flies lacking neuronal p53 activity live

Topic: Neurobiology and Insect Physiology Research
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
OBOR an Internationalized Initiative for Integrated Development

The OBOR idea, since its conception, has prompted intense discussions amid diverging views amongst scholars, practitioners, and policy makers. Various sets of arguments, revolving around OBOR’s sociopolitical, economic, geostrategic, legal, and institutional aspects, have questioned whether the initiative’s implementation can really cater to the common needs of the world community, or whether it is rather aimed at essentially benefiting one country’s interests and fulfilling its hidden agenda. Arguments from all sides have their own merit, but also their own level of inherent bias, influenced by ideological, political, and economic schooling which blurs the debate and complicates the understanding of the idea. This article, with a primary focus on legal and institutional aspects, will navigate a maze of discussions of the multivariate and multifaceted challenges OBOR faces and attempt to ratiocinate the following: that as a concept, OBOR cannot be ignored, undermined or sidelined anymore; that as a development tool, it is here to stay; and that as an approach, it will make its mark in the world arena.

Topic: International Development and Aid
Subfield: Development
Field: Social Sciences
Domain: Social Sciences