jimnoneill/paper-to-field-training huggingface dataset:
The role of ObgE in E.coli cell replication and division

Z-ring is a ring-shaped machinery which consists of FtsZ. The E.coli cell replication and division would occur after the Z-ring formation. Deficient Z-ring formation can block the cell division. FtsA and ZipA are the two proteins that attach the Z-ring to the cell membrane, make the Z-ring stable and recruit the downstream proteins to the Z-ring. FtsA can also strongly self–interact with each other. It has been proposed that the FtsA self-interaction regulates late division steps. The ObgE is a conserved GTPase critical for the survival and the growth of E.coli cells. With the depletion of ObgE, cells will filament and have more or none Z-rings, suggesting that ObgE can affect the Z-ring assembly. ObgE also shows the functions that are similar to the replication checkpoint in Eukaryotes. We hypothesize that ObgE is responsible for the conversion between the FtsA monomers and FtsA oligomers. We used the yeast two hybrid system, the split-GFP technique and the cell length measurement to confirm the prediction of this hypothesis. Consequently we believe that ObgE does influence the FtsA and regulate the FtsA monomer oligomer conversion. ObgE may have other important roles in addition to this function of the cell division checkpoint.

Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Influence of Economic Ideologies on U.S. K-12 Education Policy: Testing, Markets, and Competition

The Elementary and Secondary Education Act (ESEA) was first passed in 1965 and has since been reauthorized several times, including as No Child Left Behind in 2001 and the Every Student Succeeds Act of 2015. The ESEA seeks to address the needs of low-income students; however, decades of reform efforts and government reports documenting inequality have done little to close gaps in educational resources or outcomes for marginalized groups. Accountability systems based on standardized testing are seen by policymakers on the Left and Right as the best way to improve education for marginalized groups, improve students’ economic preparedness, hold schools accountable for the funds they spend, and maintain an objective meritocracy. This paper argues that testing is a flawed tool to achieve the goal of education equality as accountability systems rely on flawed assumptions influenced by conservative and neoliberal economic ideologies.

Topic: School Choice and Performance
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Compare with the content of complanatoside A of commercial Semen Astragali Complanati in different districts

Objective:Use the method of HPLC to determine the content of complanatoside A in commercial Semen As- tragali Complanati in different districts.Method:An HPLC method has been developed to determine complanatoside A in Semen Astragali Complanati from different districts.The mobile phase was acetonitrile-water-phosphoric acid (20:80 :0.2) at a flow rate of 1.0 mL·min~(-1);the detected wavelength was 267 nm.Result:The complanatoside A content of Se- men Astragali Complanati was markedly different compared with different districts.Conclusion:The Semen Astragali Complanati in Shaanxi has the highest content of complanatoside A and the method is stability,fast and accurate.

Topic: Traditional Chinese Medicine Analysis
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Kaempferol Inhibits Lipid Accumulation in HepG2 Cells through AMPK-Mediated Autophagy

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with metabolic syndrome. Currently, it is considered as a global health concern. Kaempferol (a flavonoid) exhibits extensive pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and neuroprotective effects. In the present study, we investigated the effects of kaempferol on free fatty acid (FFA)-induced lipid accumulation in HepG2 cells. To establish an <i>in vitro</i> model of MASLD, we treated the human hepatocellular carcinoma cell line HepG2 with FFAs. Subsequently, we performed Western blot analysis to analyze the expression levels of essential proteins associated with lipogenesis and autophagy. Vital lipogenesis-related proteins (e.g., acetyl-CoA carboxylase, fatty acid synthase, sterol regulatory element-binding protein-1c, CCAAT/enhancer-binding protein alpha, and peroxisome proliferator-activated receptor gamma) were downregulated by kaempferol treatment. Concurrently, the expression of proteins involved in fatty acid oxidation (e.g., carnitine palmitoyltransferase 1 and peroxisome proliferator-activated receptor alpha) was upregulated. These changes indicate that kaempferol promotes a shift toward enhanced fatty acid oxidation and reduced lipogenesis, thereby mitigating lipid accumulation in liver cells. Our findings suggest that kaempferol exerts a protective effect against MASLD by modulating lipid metabolism via autophagy activation.

Topic: Autophagy in Disease and Therapy
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Baroque Culture and the Polish Historical Consciousness Development

The purpose of article is to study development of the Polish historical consciousness in the 16th century when it gained new lines. Political changes, strengthening of Catholicism and sarmatizm ideology directly influenced this consciousness. The historical consciousness found bright reflection in painting and poetry. Due to the huge interest in the past genealogy became popular. The historiography turns into the main direction of human studies. At the same time nature of historical research changes. Instead of the generalizing works on stories covering all past of the Polish state since the most ancient times the works devoted to the actual problems connected with the present appear. Interest in modern political history becomes the main specifics of historical researches. XVII – the beginning of the 18th centuries became a new, special stage of the Polish-Lithuanian Commonwealth history. Deep crisis captured political, economic and social spheres; the country lost its international positions, having become object of foreign powers policy. The period of shlyakhetsky democracy with the relevant political system was replaced by time of magnates domination followed by weakening of the central power and political anarchy. The decline of the Polish-Lithuanian Commonwealth which led further to loss of independence and partitions of the state began. Speaking about development of the 16th century Polish historical consciousness it should be noted that it was caused by the level of society political and spiritual development in general. The Baroque culture and mentality peculiar to it in the Polish-Lithuanian Commonwealth found reflection in development of sarmatizm ideas. The country political system features were affected including the directions of historical researches which were concentrated on political and war events of the recent past. The Polish historical consciousness of XVI – the beginning of the 17th centuries gained a number of new characteristics which found reflection in painting, literature and first of all – in historical researches. Against huge interest in the past the genealogy and heraldry are of particular importance. At the same time historical researches become narrowly targeted and devoted generally to the events of the recent past which exerted direct impact on the present.

Topic: Historical and Cultural Studies of Poland
Subfield: History
Field: Arts and Humanities
Domain: Social Sciences
Hepatitis Carriers Among Soldiers Who Have Returned from Vietnam. Australia Antigen Studies

Australia antigen (HBAg) or antibody (HBAb) was detected by immunodiffusion in 17 of 803 Vietnam returnees, but in none of 846 recruits. It is estimated that about 58,000 hepatitis carriers will have been added to the population by servicemen returning from Vietnam. A past history of hepatitis appeared to be no more common among those with Australia antigen (HBAg) or antibody (HBAb) than in those in whom they were not found. It is recommended that all servicemen returning from Southeast Asia be tested to detect asymptomatic hepatitis carriers.

Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
The Research on Navigation Technology of Dead Reckoning Based on UWB Localization

Aiming at the problem that the accuracy and stability of indoor positioning navigation can not meet the requirements of engineering, a navigation method based on UWB positioning is designed. First of all, in view of the positioning error of UWB, the TOF algorithm is applied to measure distance, and an algorithm of inner quadrilateral positioning is proposed to improve the positioning accuracy. Secondly, In the aspect of the large deviation of navigation direction, the dead reckoning algorithm based on nine-axis module surveying angle and encoder range are designed, which effectively settle the problem of zero drift and improve the navigation precision. Finally, an integrated navigation algorithm is proposed, it combines the advantages of UWB positioning technology and dead reckoning. This method can improve the performance of positioning navigation effectively. The system can carry out indoor positioning navigation stably, rapidly and accurately through practice.

Topic: Indoor and Outdoor Localization Technologies
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Impulsive Noise Mitigation in Multicarrier Communication for High-Speed Railway

In this paper, a wireless wideband downlink transmission through a multipath and highly time-varying channel is considered for high-speed railway. In this scenario, non-Gaussian noise is generally involved at the receiver side which may lead to communication outage. In previous studies, the optimal receiver algorithms we designed are only applicable for Gaussian noise and time-invariant channels. But for impulsive noise and time-varying multipath channels, new algorithms are needed to be proposed. In order to resolve the issue, a synthesis scheme is proposed in this paper. First, we adopt impulsive noise detection algorithm to discriminate impulsive noise from the received signal. Then the discriminated noise can be suppressed by the blanking algorithm. After that, the refined signal goes through a well-designed beamforming network, which transforms the received signal with varying frequency offsets into an angle domain. Thus, the frequency offset in each angle is near-constant which can be accurately estimated. The simulation results indicate that the proposed scheme significantly improves the reliable performance of the high-speed railway communication systems.

Topic: Power Line Communications and Noise
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Das politische Potential neutestamentlicher Raumentwürfe

Abstract The following article is part of an essay trilogy dwelling on space and spatial concepts in New Testament scriptures. In the course of this, space thematic approaches are consequently utilized as an interface for political, socio-historical and theological- christological issues. The focal point of this article is an application of this space orientated approach concerning 1 Peter and Revelation.

Topic: Religious Tourism and Spaces
Subfield: Geography, Planning and Development
Field: Social Sciences
Domain: Social Sciences
Supplementary Figures 1-6 from The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

Supplementary Figures 1-6 from The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

Topic: Wnt/β-catenin signaling in development and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Rêver l’Europe. L’Europe – l’arche de Noé de l’avenir? Derrida, l’Europe et l’Hospitalité

At his last conference in France, on 8 June 2004, in Strasbourg, under the title “Le souverain bien – ou l’Europe en mal de souveraineté”, Jacques Derrida (1930-2004), always very concerned about Europe and about the future of Europe, dared to admit that he dreamed, without the slightest Eurocentrism or identitarianism, of “a Europe whose universal hospitality and new laws of hospitality or the right of asylum would make it the Noah’s Ark of the 21st century” – since the Bible (Gen. 6-9), Noah’s Ark [Tevat Noah] symbolizing the covenant, that is, Elohim’s alliance with Noah and “every living being” (Gen. 9, 15). Through the problematic of unconditional hospitality – which, as we try to point out, translates the singularity of this biblical alliance as well as underlines the singularity of Deconstruction as a philosophical idiom – , it is the silhouette of this dream of Derrida, as well as its juridical and political scope and implications not only in the European scene but also in the so-called Globalization scene, that we try to sketch here, showing how such a dream deconstructs, that is, denounces and critically re-thinks presumption and violence of the carno-fallo-logo-centric register of philosophical-cultural Westernity.

Topic: Political and Social Issues
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Prediction of volcanic ash concentrations in ash clouds based on an atmospheric transport model and the Japanese meteorological satellite Himawari-8; a case study for the Kirishima-Shinmoedake eruption on April 4th 2018

Abstract Prediction of ash concentrations in volcanic ash clouds for the Kirishima-Shinmoedake eruption on April 4th, 2018 is performed on the basis of an atmospheric transport model and the Japanese meteorological satellite Himawari-8. The retrieval algorithm for Himawari-8 (referred to as the "Optimal Volcanic Ash Algorithm", OVAA) provides two-dimensional properties of volcanic ash clouds such as cloud heights and total column mass loading, whereas it does not provide ash cloud thickness which is required to make an initial condition for the atmospheric transport model. In order to estimate ash cloud thickness, here, a wind shear index is introduced. The wind shear index includes an empirical constant parameter T c ; a small value of Tc leads to thick ash clouds, whereas a large value of T c leads to thin ash clouds. In this study, the value of T c is optimized empirically in the following two ways; (1) a comparison between the total column mass loadings in the prediction and that in the OVAA estimation, and (2) a comparison between the estimated ash cloud thickness and the observed ash cloud thickness by lidar measurements. These two comparisons suggest the optimal value of T c is 0.5-0.6, and then, the uncertainty of the ash clouds thickness estimation to be ~600 [m]. The ash concentrations prediction for T c =0.6 provides areas of high contamination (&gt;4 [mg/m 3 ]) and low contamination (&lt;2 [mg/m 3 ]). This classification of ash concentration in ash clouds has been required by the aviation industry, and is helpful information to assess safe areas and routes for airline operations.

Topic: Atmospheric aerosols and clouds
Subfield: Global and Planetary Change
Field: Environmental Science
Domain: Physical Sciences
Left ventricular diastolic dysfunction in non-cardioembolic stroke patients

要旨：非心原性脳梗塞患者における左室拡張障害の頻度および中等度以上の拡張障害の関連因子を検討した．対象は2015 年9 月～2017 年6 月に入院した発症7 日以内の非心原性脳梗塞患者100 例で，経胸壁心臓超音波検査で拡張機能を評価し，正常，弛緩障害（軽度），偽正常化（中等度），拘束型（高度）に分類した．左室拡張障害は70 例に認め，中等度以上は10 例であった．BNP 値は，中等度以上の左室拡張障害を有する群で有意に高かった（中央値26.9 vs. 96.8 pg/ml，p=0.0009）．多変量解析の結果，BNP>80 pg/ml が，中等度以上の左室拡張障害の独立した関連因子であった（OR 8.12，95％ CI 1.162–56.67，p=0.035）．非心原性脳梗塞患者は左室拡張障害を高率に合併し，BNP>80 pg/mlは中等度以上の拡張障害の存在を考慮する必要がある．

Topic: Blood Pressure and Hypertension Studies
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Effect of three-body interactions on the vapor-liquid phase equilibria of binary fluid mixtures

Gibbs-Duhem Monte Carlo simulations are reported for the vapor-liquid phase coexistence of binary argon+krypton mixtures at different temperatures. The calculations employ accurate two-body potentials in addition to contributions from three-body dispersion interactions resulting from third-order triple-dipole interactions. A comparison is made with experiment that illustrates the role of three-body interactions on the phase envelope. In all cases the simulations represent genuine predictions with input parameters obtained independently from sources other than phase equilibria data. Two-body interactions alone are insufficient to adequately describe vapor-liquid coexistence. In contrast, the addition of three-body interactions results in very good agreement with experiment. In addition to the exact calculation of three-body interactions, calculations are reported with an approximate formula for three-body interactions, which also yields good results.

Topic: Phase Equilibria and Thermodynamics
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Tardive dyskinesia and anticholinergic drugs

The evidence from the literature does not support the notion that psychotropic drugs with central anticholinergic properties (antiparkinsonian drugs, neuroleptics, antidepressants) constitute a risk factor in tardive dyskinesia. Antiparkinsonian drugs tend to produce reversible increases in the severity of dyskinetic movements and can be used as pharmacological probes in the assessment of neuroleptic-induced movement disorders.

Topic: Pathogenesis and Treatment of Hiccups
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Religious Prohibitions as Encoded Survival Wisdom: A Cross-Cultural Statistical Analysis

Background: Religious and moral systems represent universal features of human societies, yet their evolutionary origins and functional significance remain subjects of considerable debate. While traditional approaches have emphasized spiritual or social functions, emerging research suggests many religious prohibitions may encode practical survival wisdom developed over millennia.Objective: This study tests the hypothesis that religious practices systematically preserve survival-relevant knowledge across cultures through the Cultural Survival Framework, which proposes that religious systems function as sophisticated survival technologies transmitted through oral traditions.Methods: We conducted a systematic analysis of 151 religious practices from 74 cultures across six continents using a comprehensive 29-column coding framework. Each practice was classified across five survival domains (Food Safety &amp;amp; Nutrition, Disease Prevention &amp;amp; Health, Resource Conservation &amp;amp; Management, Social Cooperation &amp;amp; Stability, Environmental Adaptation) and assigned evidence levels (1-5 scale) based on documented survival benefits. Geographic distribution, cultural independence, and environmental factors were controlled to address potential confounding variables. Statistical analysis examined correlations between evidence quality and confidence assessments.Results: Religious practices demonstrated a strong positive correlation with survival benefits (r = 0.614, p &amp;lt; 0.001). Evidence levels were significantly skewed toward moderate to strong survival benefits, with 73.5% of practices achieving Levels 3-5 evidence and 37.8% reaching definitive or strong evidence (Levels 4-5). Social Cooperation &amp;amp; Stability represented the largest domain (41.7%), while Resource Conservation practices showed the highest average evidence levels. Geographic analysis revealed minimal spatial autocorrelation (Moran's I = 0.12, p = 0.23), indicating independent cultural evolution rather than diffusion from common sources.Conclusions: These findings provide compelling empirical support for the Cultural Survival Framework, demonstrating that religious prohibitions and practices systematically encode practical survival wisdom across diverse cultures. The strength and consistency of correlations suggest that survival pressures have shaped religious evolution, with practices providing genuine survival advantages being preferentially preserved and transmitted across generations. This research offers new explanations for religious universals and highlights the potential value of traditional knowledge systems for contemporary applications in public health, environmental management, and social policy.

Topic: Religion, Spirituality, and Psychology
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Transforming Healthcare through Entrepreneurial Innovations

Although digitalization has profoundly changed the business logic in many industries, the healthcare sector still operates in many areas as in the pre-digital era. During recent years, humans have witnessed the rise of new digital health ventures, many of which have revolutionary ideas of how to transform business logics in the organizational fields of healthcare. However, in many cases the institutional arrangements of the field are so strong that new ventures face major challenges in breaking the institutional elements that prevent the introduction and diffusion of service innovations. This paper studies the cases of five companies that aim to transform specific niche areas in healthcare and how these entrepreneurs perceive the influence of institutional elements on their actions.

Topic: Service and Product Innovation
Subfield: Marketing
Field: Business, Management and Accounting
Domain: Social Sciences
Role of Allergy and Airway Hyper-responsiveness in Virus-Induced Asthma

Viral respiratory infections can profoundly influence airway function and asthma through two distinct pathways (Fig. 1). First, in infancy, infections with respiratory viruses, particularly respiratory syncytial virus (RSV), can provoke episodes of wheezing, which can be recurrent (Fig. lA). Infants with reduced lung function are at greatest risk for developing wheezing with RSV infection (1 ), yet only a subset of wheezing infants will go on to develop persistent asthma. Risk factors for the development of persistent asthma after wheezing in infancy include an elevated serum IgE level at the age of 9 months and the development of allergenspecific lgE (2), suggesting that atopy may influence pulmonary physiology after wheezing induced by viral infection.

Topic: Asthma and respiratory diseases
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Supplementary Fig. S2 from Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis

Supplementary Fig. S2 from Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis

Topic: RNA modifications and cancer
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Literature and Jurisdiction

Abstract This book shows how deeply engaged early modern literature was with the technical production of the legal order and defines the ways in which jurisdictional topics provoked a metacritical perspective on the management of both legal meaning and literary meaning. For an initial survey of the scope of this primary relationship between jurisdiction and its literary-fictional analysis, and as an example of the book's approach to the literary excavation and interrogation of legal form, this chapter turns to a particular case, a poem written by Sir Thomas Wyatt to his friend John Poyntz. The poem shows the implications of jurisdiction for our understanding of both the temporal logic of legal ideology and the early constitution of the state, and for our very account of the literary and historical object. It engages and represents the law by burrowing into forms and categories, such as territoriality, to reflect outwardly an intensified version of the work that, less audibly, such categories do at law.

Topic: Law in Society and Culture
Subfield: Law
Field: Social Sciences
Domain: Social Sciences