jimnoneill/paper-to-field-training huggingface dataset:
The Results of the Intra-Articular Operation for Joint Tuberculosis with Fistulae

Eight patients of joint tuberculosis with fistulae were treated by intra-articular operation combined with chemotherapy.After the acute symptoms have subsided by means of the conservative treatments, the surgical operation was indicated. After curetting of the joints, the cavities were packed with homogenous bone chips of ribbs; in some cases the fusion operations were attempted.The chemotherapy by streptomycin and penicillin was started from two days before operation, and continued after operation. The total dosis of streptomycin were 10gr. and that of penicillin million units, from the economical standpoint of the patients.At the time of operation, streptomycin in dosis of 0.3gr. and penicillin 100, 000units were administrated locally.Although the follow-up period was to date only one year, the results obtained were excellent but one relapse, which was operated in acute stage.The duration of treatment may be reduced by means of surgical treatments combined with chemotherapy.

Topic: Infectious Diseases and Tuberculosis
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation

The rapid kinetics of [3H]inositol phosphate accumulation and turnover were examined in rat cerebral-cortex slices after muscarinic-receptor stimulation. Markedly increased [3H]inositol polyphosphate concentrations were observed to precede significant stimulated accumulation of [3H]inositol monophosphate. New steady-state accumulations of several 3H-labelled products were achieved after 5-10 min of continued agonist stimulation, but were rapidly and effectively reversed by subsequent receptor blockade. The results show that muscarinic-receptor activation involves phosphoinositidase C-catalysed hydrolysis initially of polyphosphoinositides rather than of phosphatidylinositol. Furthermore, prolonged carbachol stimulation is shown not to cause receptor desensitization, but to allow persistent hydrolysis of [3H]phosphatidylinositol bisphosphate and permit sustained metabolic flux through the inositol tris-/tetrakis-phosphate pathway.

Topic: Cellular transport and secretion
Subfield: Cell Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Functional Aspects and Physiology of the Oral Cavity

Wide excision remains the usual method for management of oral cavity carcinomas. With more advanced lesions, these resections often involve sacrifice of multiple subunits of the oral cavity. The resultant defect is rightfully of secondary concern in this ablative effort; however, our subsequent reconstructive efforts must then attempt to restore the form and function that has been lost. This effort requires an understanding of the normal physiology and function of the oral cavity and an understanding of which oral functions are most affected by which type of resection. Furthermore, we must understand the plasticity of these various functions and the potential for their recovery. Additionally, we must appreciate the effect of loss of these functions on a patient's overall quality of life. To this end, this chapter provides a brief review of the embryology of the oral cavity followed by a discussion of normal oral cavity functions, then, a discussion of abnormal functions imposed by resection, and finally, the aspects of our reconstructive efforts, which relate directly to preservation and restoration of these functions.

Topic: Oral and Maxillofacial Pathology
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Endo-α-1,4-polygalactosaminidases and their homologs: Structure and evolution

Endo-α-1,4-polygalactosaminidase is a rare enzyme. Its catalytic domain belongs to the GH114 family of glycoside hydrolases. It is shown by phylogenetic analysis that the evolution of the corresponding genes involved duplications, elimination, and horizontal transfer. The domain and secondary structures of endo-α-1,4-polygalactosaminidases are discussed. A hypothesis is put forward as to the structure of the active center of the enzyme. Iterative screening of a protein database reveals evolutionary relationships of the GH114 family with the GH13, GH18, GH20, GH27, GH29, GH31, GH35, GH36, and GH66 families of glycoside hydrolases and with the COG1306, COG1649, COG2342, GHL3, and GHL4 families of proteins with unknown enzymatic functions. Unclassified homologs are grouped into 13 new families of hypothetical glycoside hydrolases: GHL5-GHL15, GH36J, and GH36K.

Topic: Enzyme Production and Characterization
Subfield: Biotechnology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
OPTIMIZATION OF TECHNOLOGICAL PARAMETERS IN THE SPRAY DRYING OF COCONUT MILK POWDER WITH HIGH FAT CONTENT

This research focuses on the spray drying of coconut milk powder with high fat content (50% of dry weight). The spray drying was carried out by Mobile Minor TM 2002 systems (Niro, Denmark). The influence of different technological parameters on the spray drying was examined. The central composite design method was used for operation optimization. Some optimal technological parameters of the spray drying were as follows: feed concentration: 24% weight/ weight (w/w); inlet and outlet temperatures of drying agent: 155+2°C and 75+2°C, respectively; pump rate of feed: 1.6L/h and rotary speed of atomizer: 20.000rpm. In these conditions, the product recovery yield was 82.2%.

Topic: Microencapsulation and Drying Processes
Subfield: Food Science
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. An explorative cross-sectional study.

The inflammatory profile of severe periodontitis in young patients (<or=40 years) may be similar for chronic and aggressive types. Differential diagnosis between CP and AP may not be able to detect a different systemic inflammatory profile in young adults.

Topic: Oral microbiology and periodontitis research
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Football is “the most important of the least important things”: The Illusion of Sport and COVID-19

In his book, On the Pleasure Principle in Culture (2014), Robert Pfaller argued that our relationship to sport is one grounded in “illusion”. Simply put, our interest in and enjoyment of sport occurs through a process of “knowing better”. Here, one’s knowledge of the unimportance of sport is achieved by associating the illusion of sport with a naïve observer – i.e. someone who does believe in sport’s importance. In the wake of the global pandemic, COVID-19, it would seem that Pfaller’s remarks have taken on an added significance. With major sporting events and domestic competitions being indefinitely postponed or canceled, Liverpool manager, Jurgen Klopp, commented that football was “the most important of the least important things”. In light of these remarks, this paper will critically locate sport’s sudden unimportance in relation to Pfaller’s contention that sport reflects an “illusion without owner”.

Topic: Sociology and Norbert Elias
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
PET Imaging of &lt;sup&gt;18&lt;/sup&gt;F-FDG, &lt;sup&gt;11&lt;/sup&gt;C-methionine, &lt;sup&gt;11&lt;/sup&gt;C-flumazenil, and &lt;sup&gt;11&lt;/sup&gt;C-4DST in Progressive Multifocal Leukoencephalopathy

The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of <sup>18</sup>F-fluorodeoxyglucose, <sup>11</sup>C-methionine, <sup>11</sup>C-flumazenil, and [methyl-<sup>11</sup>C]4'-thiothymidine was decreased, increased, decreased, and unchanged, respectively. These results suggest that glucose metabolism decreased, protein synthesis increased, neuronal integrity decreased, and the DNA synthesis and cellular proliferation of host cells were not activated in PML lesions. These results may reflect very little infiltration by inflammatory cells and active infection with JC virus in this case.

Topic: Polyomavirus and related diseases
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
&lt;title&gt;Transmissive kinform fabricated using binary optical technique&lt;/title&gt;

The kinoform is attractive because of the high diffraction efficiency and the manner of on-axial reconstruction. In this work, we use the Gerchberg-Saxton iterative algorithms to optimize phase distribution of the kinoform. The phase in each pixel is then quantized into a set of eight-level values. The surface of quartz glass plate is etched to a depth determined by the corresponding phase retard, forming a kinform with stair-like surface relief. The optical experiments are canied out. The on-axial reconstruction image with high fidelity and high efficiency is obtained.

Topic: Optical measurement and interference techniques
Subfield: Computer Vision and Pattern Recognition
Field: Computer Science
Domain: Physical Sciences
Treatment decision making after introduction of PD-L1 reflex testing in NSCLC up front.

e21149 Background: PD-L1 testing was established in Denmark (DK) after the approval of Nivolumab (Niv) and Pembrolizumab (Pem) in second line (2L) treatment of Non-Small Lung Cancer (NSCLC) due to the requirements of PD-L1 tumor proportion score (TPS) ≥ 1% except for Niv in squamous NSCLC Reflex testing up front in the diagnostic work was established Marts 2017 in DK due to the approval of Pem in 1L NSCLC (PD-L1 TPS ≥ 50%). Re-biopsy can be challenging at progressive disease (PD) and the information from the reflex test can be used in clinical decisions in 2L. New biopsy is offered at PD in pts with unknown PD-L1 TPS and if possible in recurrent disease (RD). PD-L1 TPS, stage (TNM), performance status (PS) and co-morbidity is crucial in clinical decision making Methods: Pts examined for PD-L1 expression from 1th of Mar. until 31th of Dec. 2017 at Odense University Hospital were identified. TPS is defined as the percentage of tumor cells expressing PD-L1 assessed by immunohistochemistry (IHC) using antibody 22C3. In this retrospective study the primary treatment of NSCLC pts was assessed in patients with TPS ≥50 and 1% ≤ TPS < 50% respectively Results: Of 500 pts (lung cancer and other cancer forms) tested for PD-L1 TPS 179 (36%) had TPS ≥50%, 120 (24%) had 1% ≤ TPS < 50%, 181 (37%) TPS < 1% and 20 (4%) of biopsies were non-evaluable In 171 NSCLC with TPS ≥ 50% 40 pts (23%) received immunotherapy (IT), 20 pts (12%) 1L chemotherapy (CT) with or without (+/-) palliative radiotherapy (RT) up front, 52 pts (30%) treated with curative intention (CI), 23 pts (14%) only palliative RT and 24 pts (13%) no treatment at all. EGFR mutation was found in 7 pts (4%) and 5 pts (3%) were treated in another region In 102 NSCLC with 1% ≤ TPS < 50% 34 pts (33%) with newly diagnosed or recurrent disease received 1L CT +/- palliative RT up front, 30 pts (29%) treated with CI, 15 pts (15%) only palliative RT and 12 pts (12%) no treatment at all. In 5 pts (5%) PD-L1 TPS assessment was in order to decide 2L treatment. Only 1(20%) received IT and 4 (80%) CT in 2L Conclusions: In PD-L1 TPS ≥ 50% only 23% of all tested NSCLC in our study are candidates for IT in 1L. The reflex testing helps the clinician to identify the pts that benefit from 1L IT. It gives important knowledge for further treatment decision making in pts with PD or RD too

Topic: Cancer Immunotherapy and Biomarkers
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

&lt;p&gt;Exome Tumor VAF Distribution and Exome Tumor Coverage Partitioned by Validation Status&lt;/p&gt;

Topic: Cancer Genomics and Diagnostics
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Carcass and body components of suckling lambs grazing ryegrass and supplemented with legume or concentrate

ABSTRACT This research objective was to evaluate the effect of private supplementation with concentrated or legumes, on the carcass characteristics and body components from suckling lambs kept on ryegrass pasture. Twenty seven suckling lambs were used, with about 17 days of age and weighing 9,91±0,594kg, which were distributed in the treatments that corresponded to feeding systems: suckling lambs kept on ryegrass pasture, suckling lambs kept on ryegrass pasture and supplemented with concentrated in private feeder (creep feeding) and suckling lambs kept on ryegrass pasture and supplemented with legume in the private pasture (creep grazing). The concentrate supplement was composed by corn, soybean meal and limestone, and was supplied ad libitum. The supplementary pasture was white clover legume. The experimental design was completely randomized, where the results were submitted to analysis of variance and means compared by Tukey test at 5% of significance level. The gastrointestinal+bile+urine content and the proportion of esophagus were higher (P&lt;0,05) in lambs kept on ryegrass. The liver and large intestine proportions were higher (P&lt;0,05) in lambs supplemented with concentrate. The tested alimentary systems produce carcasses with similar characteristics. The supplementation with legume or concentrate cause changes in body components of suckling lambs grazing ryegrass.

Topic: Agriculture and Biological Studies
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Acute otitis externa in children: causes, diagnosis, treatment, clinical report

Acute otitis externa is a common disease in the pediatric population, characterized by diffuse inflammation of the external auditory canal. Typical symptoms of acute otitis externa include otology, itching, congestion, and a feeling of fullness in the sore ear. In the case of active inflammation, the process can go to the tympanic membrane, and acute otitis media will join the external one. Primary therapy for diffuse uncomplicated acute otitis externa should include a local antimicrobial drug, without systemic antibiotic therapy. Topical therapy with antibacterial drugs in combination with anesthetics is the most rational. A clinical case of a 12-year-old patient with acute diffuse otitis externa and otitis media with effusion; acute nasopharyngitis; and adenoiditis, which was established based on anamnesis and clinical data is presented. Complex therapy was prescribed, which included local antibiotic therapy with a complex topical drug for the treatment of imperforated otitis externa and imperforated otitis media. At reexamination 5 days later, the patient demonstrated positive dynamics, pain in the left ear was eliminated. In cases of uncomplicated diffuse otitis externa, as well as in cases of its combination with otitis media with effusion, topical antibiotic therapy is a major priority. It should be borne in mind that the topical medication is more effective with the cleansing of the external auditory canal from inflammatory secretion. If it is used correctly, it would provide positive dynamics without systemic antibiotic prescription. It preserves the microbiome and mobilizes the body’s defenses. The application of complex topical antibiotic drugs can be widely recommended in pediatric practice.

Topic: Ear Surgery and Otitis Media
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
The Danish Fetal Medicine Database

Charlotte Kvist Ekelund,1 Tine Iskov Kopp,2 Ann Tabor,1 Olav Bj&oslash;rn Petersen3 1Department of Obstetrics, Center of Fetal Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; 2Registry Support Centre (East) &ndash; Epidemiology and Biostatistics, Research Centre for Prevention and Health, Glostrup, Denmark; 3Fetal Medicine Unit, Aarhus University Hospital, Aarhus Nord, Denmark Aim: The aim of this study is to set up a database in order to monitor the detection rates and false-positive rates of first-trimester screening for chromosomal abnormalities and prenatal detection rates of fetal malformations in Denmark. Study population: Pregnant women with a first or second trimester ultrasound scan performed at all public hospitals in Denmark are registered in the database. Main variables/descriptive data: Data on maternal characteristics, ultrasonic, and biochemical variables are continuously sent from the fetal medicine units&#39; Astraia databases to the central database via web service. Information about outcome of pregnancy (miscarriage, termination, live birth, or stillbirth) is received from the National Patient Register and National Birth Register and linked via the Danish unique personal registration number. Furthermore, results of all pre- and postnatal chromosome analyses are sent to the database. Conclusion: It has been possible to establish a fetal medicine database, which monitors first-trimester screening for chromosomal abnormalities and second-trimester screening for major fetal malformations with the input from already collected data. The database is valuable to assess the performance at a regional level and to compare Danish performance with international results at a national level. Keywords: prenatal screening, nuchal translucency, fetal malformations, chromosomal abnormalities

Topic: Neonatal Respiratory Health Research
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Constrained Participation: The Impact of Consultative Councils on National-Level Policy in Mexico

The beginning of the twenty-first century brought good news to Mexico. After 70 years of uninterrupted rule by the Institutional Revolutionary Party (PRI), alternation of power had been achieved, the economy was recovering from the crisis of 1995, and the Zapatista National Liberation Army (EZLN) appeared before Congress following its march into Mexico City. Meanwhile, civil society organizations (CSOs), which had been central to the process of democratization in the 1990s, were accessing public space as actors with significant voice. The agenda of the "government of change" highlighted new ways of relating to civil society. This included creating spaces and mechanisms for communication with CSOs, strengthening transparency and public access to government information, and placing CSO leadership in important government positions in the area of social development as well as in the presidency (Isunza Vera and Hevia, 2006).1 KeywordsCivil SocietyEnvironmental PolicyNational CouncilCivil Society OrganizationRegional CouncilThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Topic: Public Policy and Governance
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Supplementary Methods from Silencing of the &lt;i&gt;miR-17∼92&lt;/i&gt; Cluster Family Inhibits Medulloblastoma Progression

&lt;p&gt;PDF file - 62K, Confocal microscopy was performed using a confocal/multiphoton microscope.&lt;/p&gt;

Topic: MicroRNA in disease regulation
Subfield: Cancer Research
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
The Geriatric Depression Scale and Hopelessness Index: Longitudinal Psychometric Data on Frail Nursing Home Residents

We administered the Geriatric Depression Scale and the Hopelessness Index 18 times over a 39-wk. period to an initial sample of 76 old, frail, multiply impaired, and depressed nursing home residents participating in a longitudinal quasi-experimental study on the effects of cognitive group interventions on cognition, depression, hopelessness, and life satisfaction. As no changes over time were observed on the outcome variables of geriatric depression and hopelessness, the stability of the instruments' internal consistency was examined longitudinally. For the Geriatric Depression Scale, Kuder-Richardson KR-20 coefficients ranged from .69 to .88, with a mean of .82 ( SD = .05). Coefficients for the Hopelessness Index were between .72 and .86, with a mean of .80 ( SD = .04). We conclude that both instruments give reliable measurements of geriatric depression and hopelessness in old, frail, and depressed nursing home residents.

Topic: Health disparities and outcomes
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
COMPARISON OF SHOULDER PAIN, DISABILITY AND RANGE OF MOTION IN DIABETIC AND NON-DIABETIC PATIENTS WITH FROZEN SHOULDER

OBJECTIVE: To compare the shoulder pain, disability, and range of motion in diabetic and non-diabetic frozen shoulder (FS) patients. METHODS: This cross-sectional study was conducted from December 2018 to June 2019 on 210 clinically diagnosed patients of FS. Study included equal number (n=105) of diabetes mellitus (DM) patients and non-diabetic patients, ranging in age from 35 to 65 years. Non-probability purposive sampling was used to assemble the data from various private and government hospitals of Lahore. A plastic goniometer and shoulder pain and disability index (SPADI) tool was used to extract data. Data was analyzed through SPSS v.21.0. RESULTS: In 210 patients with frozen shoulder, the mean age was 53±10.3 years & 48±9.9 years in DM & non-diabetic patients respectively (p=0.94). Frequency of male & female patients was 43 (40.95%) and 62 (59.05%) in diabetic group (n=105) & 38 (36.19%) and 67(63.81%) in non-diabetic group (n=105) respectively. Mean body mass index was 25.61±2.14 & 25.39±2.16 in diabetic & non-diabetic patients respectively (p=0.32). Mean SPADI score was 66.69±13.20 in diabetic and 63.34±15.01 in non-diabetic group (p=0.191). Regarding motion range at shoulder, mean degrees of flexion, external rotation, internal rotation and abduction were 103±23.07, 30±11.20, 34±11.970 & 101±25.55 in diabetic patients as compared to 113±29.61, 39±14.34, 40±15.77 & 109±33.80 in non-diabetic patients respectively (p=≤0.05). CONCLUSION: There is no significant difference in severity of pain and disability in diabetic & non-diabetic patients with frozen shoulder. However, range of motion was significantly better in non-diabetic patients as compared to diabetic patients having frozen shoulder.

Topic: Pain Management and Treatment
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
The Impact of Customer Experience Quality on Customer Loyalty in Motor Vehicle Insurance Industry: The Mediating Role of Relationship Quality

Cultivating high-quality relationship with customers is important to nurture customer loyalty especially in the financial service and insurance industry which is characterized as a highly intangible and complex industry. However, there is only a dearth of research that examines the role of relations

Topic: Customer Service Quality and Loyalty
Subfield: Organizational Behavior and Human Resource Management
Field: Business, Management and Accounting
Domain: Social Sciences
The production of Olympic champions: international perspectives on elite sport development systems

The paper explores national elite sport development systems in Europe (UK, France, Spain), North America (Canada, USA) and Australia and discusses the move towards, and the applicability of, a homogeneous elite sport development model. Since 1990, and the dissolution and fragmentation of the former communist states, the use of elite sport development strategies and sport institute networks has increased. Using study visits, interviews and a comprehensive review of secondary sources the paper demonstrates similarities in national elite development strategies and accounts for any national differences. In support of this aim, the efficiency of the six selected countries in producing Olympic medals in relation to population size over the last four Olympiads is investigated and significant 'focusing events' for each country identified.

Topic: Sport and Mega-Event Impacts
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences