jimnoneill/paper-to-field-training huggingface dataset:
How fast a protein chain can fold to its most stable structure?

Article Free Access Share on How fast a protein chain can fold to its most stable structure? Authors: Alexei V. Finkelstein Institute of Protein Research, Russian Academy of Sciences, 142292, Pushchino, Moscow Region, Russian Fedaration Institute of Protein Research, Russian Academy of Sciences, 142292, Pushchino, Moscow Region, Russian FedarationView Profile , Azat Ya. Badretdinov Institute of Protein Research, Russian Academy of Sciences, 142292, Pushchino, Moscow Region, Russian Fedaration, and Rockefeller University, Box 270, 1230 York Ave., New York, NY Institute of Protein Research, Russian Academy of Sciences, 142292, Pushchino, Moscow Region, Russian Fedaration, and Rockefeller University, Box 270, 1230 York Ave., New York, NYView Profile Authors Info & Claims RECOMB '98: Proceedings of the second annual international conference on Computational molecular biologyMarch 1998 Pages 74–78https://doi.org/10.1145/279069.279091Published:01 March 1998Publication History 0citation198DownloadsMetricsTotal Citations0Total Downloads198Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF

Topic: Protein Structure and Dynamics
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue.

These data may help with selection of antihypertensive drugs, in order to determine which drugs have the lowest toxicity in pregnant and non-pregnant (pre-pregnancy) women.

Topic: Pregnancy and preeclampsia studies
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
The Research of Acquisition Levels of Concepts Regarding Social Studies Lesson: A Quantitative Research

Article History: Received 20.01.2014 Received in revised form 22.02.2014 Accepted 10.03.2014 Available online 21.04.2014 In the 2005 Social Studies Programme, it was identified in which classes the concepts will be taught in the programme in steps of introduction, development and reinforcement.The concepts in this regard were subject to classification according to thelevels, interest, desire and needs of students. This research aims to identify the level of acquisition by school boys and girls of the concepts of introduction, development and reinforcement levels in the Social Studies the 4th, 5th, 6th and 7th grades. In this study, in which a descriptive method was used, the existing situation and conditions were researched as the year. It can be said that the success rates of the levels of acquisition as a result of concept teaching in the levels of the 4th and the 5th grade sare in sufficient at the level of following the lower class (The 4th grade) and the upper class level (the 5th grade) in the stage of “Introduction and Development” of the 4th and the 5th grades. Looking into the distribution of the concepts given the 6th and the 7th grades at the level of “introduction, development and reinforcement”, both in the 6th as well as in the 7th grades, most of the concepts given were seen to be “reinforcement” level concepts. Grades concepts, the “gender” variable of students are not influential and it can be added that the levels of success/failure achieved/suffered are independent of the effect of “gender” factor. In this regard, the fact that the acquisition states of social studies concepts of the 4th Grade students are higher compared to those of the 5th grade, and the states of the 6th grade students in comparison to those of the 7th grades clearly suggest that education/teaching studies regarding the same concepts for two consecutive years are inadequate. Among the reasons for these insufficiencies, we can state that educational-training activities are not conducted or supported enough with suitable methods, techniques and strategies. © 2014 IOJES. All rights reserved

Topic: Values and Moral Education
Subfield: Education
Field: Social Sciences
Domain: Social Sciences
Program Kemitraan Kemasan Untuk Meningkatkan Daya Saing UMKM Di Makale Tana Toraja

The Packaging Partnership Program is an initiative that aims to increase the competitiveness of Micro, Small and Medium Enterprises (MSMEs) through improving the quality of product packaging. Attractive and functional packaging is the key to attracting consumer interest and increasing market share. This program is carried out through a series of activities, including education, training, design assistance, introduction of environmentally friendly packaging materials, testing, evaluation, implementation and product promotion. Through this program, MSMEs can increase their competitiveness in the market, increase sales, increase environmental awareness, and gain new knowledge and skills in designing product packaging. Collaboration between government, non-profit institutions and the private sector is the key to success in supporting MSMEs and encouraging inclusive economic growth.

Topic: Agriculture and Agroindustry Studies
Subfield: General Agricultural and Biological Sciences
Field: Agricultural and Biological Sciences
Domain: Life Sciences
Nucleic Acid‐Based Microarrays and Nanostructures

Supplement 18Dendrimeric layers terminating in an amino group may be used directly for in situ DNA synthesis or, after transformation to an acrylamide or 4-nitrophenylformate moiety, as a substrate for attachment of amino-labeled oligonucleotides.

Topic: Gene expression and cancer classification
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
Foxp3+ Treg Cell Activity increases in Secondary Lymphoid Organs of Aged Mice (88.25)

Abstract As potent suppressors of immune responses to self and foreign antigens, Foxp3+ Treg cells are suspected to be involved in immunosuppression leading to cancer, neurodegeneration and infection. Since aging is associated with increased incidence of these diseases, we compared Treg activity in blood, lymphoid organs and lungs of young (5–6 months) and old (21–22 months) C57BL/6 mice, using flow cytometric detection and characterization of Foxp3+ cells. Both the proportion and absolute number of Treg cells increased with age in secondary lymphoid organs but not in blood and lungs. Whereas numbers of thymic and peripheral naive Treg cells decreased with age, the number and proportion of Treg cells with CD103+ memory/effector phenotype increased in peripheral lymphoid tissues. Moreover, the increased Treg activity had in vivo influence since CD40 and CD86 co-stimulatory molecule expression by lymph node dendritic cells (DCs) was impaired in old mice, but could be restored to levels of young mice by inactivating Treg cells with anti-CD25 mAb. Our findings suggest that immunosenecence involves a cumulative imbalance of Treg cell activity and have profound implication for the understanding of age-associated immune dysfunction. This work was supported by the American Foundation for Aging Research (AFAR) and the Department of Veterans Affairs.

Topic: Immune Cell Function and Interaction
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Confidence and Pertinacity in Evangelical Abolitionism: Lewis Tappan's Circle

IN HIS 1933 STUDY, The Antislavery Impulse, GILBERT HOBBS Barnes demonstrated for first time that not all antebellum American abolitionists were radical Garrisonians. There were also conservative abolitionists like Theodore Weld and James Birney who drew upon reformist aspects of Finneyite Great Revivals of 1820s and 1830s. Their aim was not social revolution; instead, they simply sought to make nation's religious and political institutions unambiguously antislavery. In more recent years, scholars have noted that all conservative abolitionists were not same. Although all conservatives were sympathetic with Liberty Party during 1840s, a number remained more concerned with reforming evangelical Protestant denominations than building an antislavery political movement. Bertram Wyatt-Brown's 1969 biography, Lewis Tappan and Evangelical War against Slavery, has been most sophisticated effort at characterizing these evangelical church-oriented conservatives. Wyatt-Brown's achievements were two-fold. Differing with Barnes, he demonstrated that evangelical conservatives did not restrict their activities to Midwest; various groups also operated throughout Northeast. Second, Wyatt-Brown showed how the evangelicals of [Lewis] Tappan's immediate circle formed most influential group of church-centered abolitionists through their dominant role on American and Foreign Anti-Slavery Society, American Missionary Association, and New York City Abolition Society, as well as through their funding of Oberlin and Oneida Institutes-the principal training grounds for evangelical antislavery clergy. But because Wyatt-Brown's focus was biographical, he was unable to provide detailed analysis of values and interactions within Tappan's immediate circle.

Topic: American Constitutional Law and Politics
Subfield: Political Science and International Relations
Field: Social Sciences
Domain: Social Sciences
Electroconvulsive therapy in later life

Electroconvulsive therapy (ECT) is not contraindicated by advanced age. Indeed, over the years a number of studies have reported a more favorable treatment response in elderly people (Gold & Chiarella, 1944; Hobson, 1953; Roberts, 1959; Mendels, 1967; Coryell & Zimmerman, 1984). Reviewers have concluded, modestly, that elderly people respond to ECT at least as well as younger people (Weiner, 1982; Benbow, 1989). There are, however, particular areas of concern for clinicians who prescribe ECT for elderly people: concurrent physical illness is often present, and possible side-effects may worry doctor, relatives and patient.

Topic: Electroconvulsive Therapy Studies
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Stillness and movement: a bodily approach to photography

\n\t\t\t\t\tMy paper will address both Duration and temporality of the &amp;lsquo;still&amp;rsquo; imageand Sensorial and bodily experience of photography through a discussion of a recent body of work &amp;lsquo;Fly Rhythm&amp;rsquo;, a series of photographs and video works exhibited in a gallery context.By acknowledging the inter-relationship between the body and the camera my project seeks to challenge a perceived separation between performance and photography. Fly Rhythm was conceived through a performative somatic process. Through using a custom made camera I was able to negotiate time and space to create a visual drawing of movement and stillness together in photography. The resultant images are discussed as a notation of body movement &amp;ndash; a record of bodily history enabled through a self imposed discipline of learning to read light.I initially constructed a human size camera to understand how photography works. Spending time inside observing the way light moves and affects the formation of sight is also a way of embodying the act of photography. I responded by making a bespoke camera that enabled light to be captured during extended periods while moving. My project is dependent upon a self-imposed discipline of intuiting light&amp;rsquo;s strength and erratic changes, a skill developed by making analogue prints while inside a camera obscura. Once I had developed an ability to read light&amp;rsquo;s changes and gain an understanding of camera mechanics I made durational recordings moving through the landscape on Bruny Island Tasmania and industrial sites in Melbourne, photographs exhibited as part of Fly Rhythm. I will discuss these prints in context with the idea that light is a conduit through which past and present fuse together in a bodily act of photographing and processing images.I will explore durational aspects of photography by discussing light&amp;rsquo;s relative motion while taking photographs without using the viewfinder or composing images in the traditional way. Rather, the camera at the end of my arm is directed through how I read light therefore a choreography notated in the prints &amp;ndash; a kind of body signatureMy practice enables a new the way of seeing, in a spontaneous hand held process creating a sense of embodiment. By analyzing process my paper will consider how the body together with analogue and 21st century digital technology coalesce cross-disciplinary practice combining visual art, performance and photographic disciplines.I also explored limitations of digital light in contrast with &amp;lsquo;natural&amp;rsquo; light by a making a gamut of dissolving colour determined by the software based on two pixels. Projected into the ambient light &amp;lsquo;Glide&amp;rsquo; is an 11minute durational work installed at the Substation Contemporary Art Space in Melbourne Australia.\n\t\t\t\t

Topic: Theatre and Performance Studies
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
Making Space for Creative Writing Research in the Academy

The field of creative writing stands once again at a crossroads. On one side of the road is a course of study, a ‘discipline’ that is unaware of the histories and theories that inform its practice.... On the other side of the road is creative writing studies, an emerging field of scholarly inquiry and research. As an academic discipline, it explores and challenges the pedagogy of creative writing. (1)

Topic: Artistic and Creative Research
Subfield: Visual Arts and Performing Arts
Field: Arts and Humanities
Domain: Social Sciences
To Investigate Different Parameters of Economic Sliding Based Seismic Isolation System

Masonry structures are frequently constructed in developing countries because of their affordability and ease of construction, even though they are vulnerable and perform poorly during earthquakes. Experimental and numerical studies were carried out to determine the optimum thickness of the isolation layer for a recently developed, low-cost seismic isolation system known as the Reinforced-Cut-Wall (RCW). The parameters of the isolation layer were optimized during the experimental and numerical investigations using hollow concrete blocks. Quasi-static cyclic tests were performed on a 1:3 reduced-scale brick masonry wall incorporating the RCW isolation scheme, validating the better performance of the proposed isolation technique.

Topic: Masonry and Concrete Structural Analysis
Subfield: Civil and Structural Engineering
Field: Engineering
Domain: Physical Sciences
Meta-analysis on the Role of High-sensitivity C-reactive Protein Monitoring in Relation to the Presence of Glucose Intolerance in Patients Treated with HMG-CoA Reductase Inhibitors

To study whether the monitoring of serum high sensitivity C-reactive protein (hs-CRP) would be a unique biomarker of cardiovascular risks, being independent of serum LDL-cholesterol, in patients with or without glucose intolerance receiving an HMG-CoA reductase inhibitor (statin), we conducted a meta-analysis study on the data retrieved from MEDLINE, Cochrane Central Register of Controlled Trials, Japan Medical Abstracts Society. Fifty-four placebocontrolled randomized clinical trials consisting of 34,746 patients (841 of them were documented as having glucose intolerance and 18,572 were not) were analyzed. Results showed that patients receiving one of the statins expressed a significant decrease in the weighted mean difference (WMD) of hs-CRP with a 95% confidence interval (CI) (−0.53 mg/L; −0.63 to −0.42, p<0.001)and that of LDL-cholesterol (−50.8 mg/L; −54.4 to −47.1, p<0.001) as compared to those receiving placebo. While statins produce a smaller reduction in the WMD of serum hs-CRP in patients with glucose intolerance (−0.54 mg/L; −0.92 to −0.17, p<0.001) than those without (−0.73 mg/L; −1.09 to −0.37, p<0.001), the difference was not significant. Weighted Spearman's correlation analysis showed no significant correlations between the changes in LDL-cholesterol and hs-CRP after statin therapy in overall patients and subgroups consisting of those with or without impaired glucose tolerance. In this context, we concluded that hs-CRP may be a unique cardiovascular risk factor, not substitutable for LDL-cholesterol, in patients receiving statins irrespective of glucose intolerance.

Topic: Lipoproteins and Cardiovascular Health
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Effects of oral contraceptives on the quality of life of women with polycystic ovary syndrome: a crossover randomized controlled trial

Abstract Background and objective A limited number of studies have evaluated the effects of oral contraceptives (OCs) on the quality of life (QOL) of polycystic ovary syndrome (PCOS) patients. This study aimed to compare the effects of using OCs containing levonorgestrel (LNG) and those containing desogestrel (DSG), cyproterone acetate (CPA) or drospirenone (DRSP) for 6 months on the QOL with PCOS. Methods In this crossover randomized controlled 6-arm trial, 200 eligible patients with PCOS scheduled for OC therapy were randomly assigned to one of the 6 study arms. All 6 arms include two 6-month treatment periods, one period with OCs containing LNG, and the other with each of the 3 OCs containing DSG, CPA, or DRSP. Outcomes of interest were the total score of QOL and its domains, which were assessed using a specific and valid health‐related quality of life questionnaire for PCOS, which is consisted of six domains, including psychosocial–emotional, self-image, fertility, sexual function, hirsutism, and obesity– menstrual disorders. Results Finally, a total of 88 patients were analyzed for this study. The results showed that use of OCs containing DSG, CPA, and DRSP for 3 months was not associated with significant differences in the total scores of QOL compared to those OCs containing LNG, whereas, after 6 months of treatment, patients treated with OCs containing CPA had more improvements in their total scores of QOL, in comparison to OCs containing LNG (P &lt; 0.042). We found no significant differences in QoL domains, including psychosocial–emotional, self-image, fertility, sexual function, hirsutism, and obesity-menstrual disorders after 3- 6 months of treatment with DSG, CPA, or DRSP, compared to LNG. The sequence and period effects were not significant in any of the analyses at 3 and 6 months of treatment. The carry-over effect was not significant for most outcomes assessed. Conclusions This crossover study demonstrated non-inferiority of OCs with newer generation progestins on different domains of QOL, in comparison with older compounds, although usage of products containing CPA was significantly associated with more improvement in total QOL of PCOS patients, compared to those containing LNG after 6-month of treatment. Clinical Trial Registration Number: IRCT201702071281N2.

Topic: Ovarian function and disorders
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Effects of a Psychosocial Intervention on the Executive Functioning in Children With ADHD

The purpose of this study was to analyze the effects of an intensive psychosocial intervention on the executive functioning (EF) in children with ADHD. The treatment was carried out in a coordinated manner over a period of 10 weeks with 27 children with ADHD aged 7 to 10, their parents, and their teachers. A battery of neuropsychological tasks was applied to evaluate attention, interference control, verbal and visuospatial working memory, planning ability, and flexibility. The comparative analysis of the treated group of ADHD children and an untreated ADHD group showed significant differences that were especially important in visuospatial memory and planning in favor of the treated children, even when the scores in the pretreatment phase were included as covariables. Likewise, improvements were observed in the parents’ and teachers’ behavioral ratings of hyperactivity or impulsivity and inattention. The conclusion was drawn that psychosocial interventions with children with ADHD can have a positive effect on some executive functions.

Topic: Attention Deficit Hyperactivity Disorder
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Thucydides and Herodotus

'Thucydides and Herodotus' is an edited collection which looks at two of the most important ancient Greek historians living in the 5th century BCE. It examines the relevant relationship between them which is considered, especially nowadays, by historians and philologists to be more significant than previously realized

Topic: Classical Antiquity Studies
Subfield: Anthropology
Field: Social Sciences
Domain: Social Sciences
Befriending the Religious Other: The Possibility and Blessing of Interreligious Friendship

precis: Taking seriously the challenge posed by religious difference to interreligious friendship, this essay argues for the possibility of this form of friendship from a Christian theological viewpoint. In arguing for interreligious friendship’s possibility, the essay goes against accounts of friendship, such as that influentially articulated by Aristotle, wherein friendship’s possibility is predicated on the would-be friends’ sharing agreement. Instead of this, drawing on Janet Soskice’s theological anthropology of friendship, it argues that friendship with the religious other is possible given that the reality of our ontological distance from the divine Godhead does not close off divine-human friendship. Finally, it suggests that this form of friendship offers important sources of spiritual and moral nourishment.

Topic: Religion and Society Interactions
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

Significance Influx of calcium ions through surface membrane calcium channels that open in response to electrical signals is important for vital biological processes including generation of the heartbeat and nerve cell communication. Blocking such calcium channels in a tissue- and isoform-specific manner is a sought-after treatment strategy for diseases including chronic pain and Parkinson’s disease. Proteins that can be expressed in cells to selectively block different calcium channel types have particular advantages over conventional small-molecule blockers. A four-member family of proteins known as RGK proteins strongly inhibit calcium channels, but do so in a non-selective manner, limiting their potential usefulness. Here we identified mutated RGK proteins that perform as isoform-selective calcium channel blockers, advancing the therapeutic potential of these proteins.

Topic: Ion channel regulation and function
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences